Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 4, 2006, Pages 1446-1452

  Barrows, Brian R ^a   Parks, Elizabeth J ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; FATTY ACID; PALMITIC ACID; STABLE ISOTOPE; TRIACYLGLYCEROL; TRIPALMITIN; VERY LOW DENSITY LIPOPROTEIN; CHYLOMICRON; INSULIN; RADIOPHARMACEUTICAL AGENT;

ADIPOSE TISSUE; ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; DIET RESTRICTION; FATTY ACID BLOOD LEVEL; FEEDING; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; LIPOGENESIS; LIPOPROTEIN SYNTHESIS; LIVER; MALE; METABOLITE; NORMAL HUMAN; PRIORITY JOURNAL; STEADY STATE; BLOOD; CLINICAL TRIAL; DIET; FEMALE; GLUCOSE BLOOD LEVEL; MASS FRAGMENTOGRAPHY; METABOLISM; MIDDLE AGED; POSTPRANDIAL STATE;

ADIPOSE TISSUE; ADULT; BLOOD GLUCOSE; CHYLOMICRONS; DIET; FASTING; FATTY ACIDS; FATTY ACIDS, NONESTERIFIED; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; INSULIN; LIPOPROTEINS, VLDL; MALE; MIDDLE AGED; POSTPRANDIAL PERIOD; RADIOPHARMACEUTICALS; TRIGLYCERIDES;

EID: 33646035836     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-1709     Document Type: Article

References (41)

1. Hokanson JE, Austin MA 1996 Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population based prospective studies. J Cardiovasc Risk 3:213-219
2. Patsch JR, Miesenbock G, Hopferwieser T, Muhlberger V, Knapp E, Dunn JK, Gotto AM, Patsche W 1992 Relations of triglyceride metabolism and coronary artery disease: studies in the postprandial state. Arterioscler Thromb 12:1336-1345
3. Havel RJ 1994 Postprandial hyperlipidemia and remnant lipoproteins. Curr Opin Lipidol 5:102-109
4. Parks EJ 2001 Recent findings in the study of postprandial lipemia. Curr Atheroscler Rep 3:462-470
5. Cohn JS 1998 Postprandial lipemia: emerging evidence for atherogenicity of remnant lipoproteins. Can J Cardiol 14:18B-27B
6. Farquhar JW, Gross RC, Wagner RM, Reaven GM 1965 Validation of an incompletely coupled two-compartment nonrecycling caternary model for turnover of liver and plasma triglyceride in man. J Lipid Res 6:119-134
7. Havel RJ 1961 Conversion of plasma free fatty acids into triglycerides of plasma lipoprotein fractions in man. Metabolism 10:1031-1034
8. Parks EJ, Krauss RM, Christiansen MP, Neese RA, Hellerstein MK 1999 Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production and clearance. J Clin Invest 104:1087-1096
9. Aarsland A, Chinkes D, Wolfe RR 1996 Contributions of de novo synthesis of fatty acids and lipolysis to VLDL secretion during prolonged hyperglycemia/hyperinsulinemia in normal man. J Clin Invest 98:2008-2017
10. Hudgins LC, Hellerstein M, Selfman C, Neese R, Diakun J, Hirsch J 1996 Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet. J Clin Invest 97:1-11
11. Timlin MT, Parks EJ 2005 The temporal pattern of de novo lipogenesis in the postprandial state. Am J Clin Nutr 81:35-42
12. Windler E, Greeve J, Robenek H, Rinninger H, Greten H, Jackle S 1996 Differences in the mechanisms of uptake and endocytosis of small and large chylomicron remnants by rat liver. Hepatology 24:344-351
13. Heimberg M, Dunn GD, Wilcox HG 1974 The derivation of plasma free fatty acids from dietary neutral fat in man. J Lab Clin Med 83:393-402
14. Miles JM, Park YS, Walewicz D, Russell-Lopez C, Windsor S, Isley WL, Coppack SW, Harris WS 2004 Systemic and forearm triglyceride metabolism: fate of lipoprotein lipase-generated glycerol and free fatty acids. Diabetes 53:521-527
15. Whitley HA, Humphreys SM, Samra JS, Campbell IT, Maclaren DPM, Reilly T, Frayn KN 1997 Metabolic responses to isoenergetic meals containing different proportions of carbohydrate and fat. Br J Nutr 78:15-26
16. Heath RB, Karpe F, Milne RW, Burdge GC, Wootton SA, Frayn KN 2003 Selective partitioning of dietary fatty acids into the VLDL TG pool in the early postprandial period. J Lipid Res 44:2065-2072
17. Balletshofer BM, Rittig K, Volk A, Maerker E, Jacob S, Rett K, Haring H 2001 Impaired non-esterified fatty acid suppression is associated with endothelial dysfunction in insulin resistant subjects. Horm Metab Res 33:428-431
18. de Kreutzenberg SV, Puato M, Kiwanuka E, Del Prato S, Pauletto P 2003 Elevated non-esterified fatty acids impair nitric oxide independent vasodilation, in humans: evidence for a role of inwardly rectifying potassium channels. Atherosclerosis 169:147-153
19. Lundman P, Tornvall P, Nilsson L, Pernow J 2001 A triglyceride-rich fat emulsion and free fatty acids but not very low density lipoproteins impair endothelium-dependent vasorelaxation. Atherosclerosis 159:35-41
20. Kotite L, Bergeron N, Havel RJ 1995 Quantification of apolipoproteins B-100, B-48, and E in human triglyceride-rich lipoproteins. J Lipid Res 36:890-900
21. Donnelly K, Smith C, Schwarzenberg S, Jesserun J, Parks EJ 2005 Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115:1343-1351
22. Karpe F, Olivecrona T, Hamsten A, Hultin M 1997 Chylomicron/chylomicron remnant turnover in humans: evidence for margination of chylomicrons and poor conversion of larger to smaller chylomicron remnants. J Lipid Res 38: 949-961
23. Hellerstein MK 1999 De novo lipogenesis in humans: metabolic and regulatory aspects. Euro J Clin Nutr 53:S53-S65
24. Barter PJ, Nestel PJ 1972 Plasma free fatty acid transport during prolonged glucose consumption and its relationship to plasma triglyceride fatty acids in man. J Lipid Res 13:483-490
25. Barter PJ, Nestel PJ, Carroll KF 1972 Precursors of plasma triglyceride fatty acid in humans. Effects of glucose consumption, clofibrate administration, and alcoholic fatty liver. Metabolism 21:117-124
26. Patterson BW, Mittendorfer B, Elias N, Satyanarayana R, Klein S 2002 Use of stable isotopically labeled tracers to measure very low density lipoprotein-triglyceride turnover. J Lipid Research 43:223-233
27. Basso LV, Havel RJ 1970 Hepatic metabolism of free fatty acids in normal and diabetic dogs. J Clin Invest 49:537-547
28. Boberg J, Carlson LA, Freyschuss U 1972 Determination of splanchnic secretion rate of plasma triglycerides and of total and splanchnic turnover of plasma free fatty acids in man. Eur J Clin Invest 2:123-132
29. Boberg J, Carlson LA, Freyschuss U, Lassers BW, Wahlqvist ML 1972 Splanchnic secretion rates of plasma triglycerides and total and splanchnic turnover of plasma free fatty acids in men with normo- and hypertriglyceridaemia. Eur J Clin Invest 2:454-466
30. Eaton P, Steinberg D, Berman M 1965 Quantitative evaluation of free fatty acid and glyceride fatty acid metabolism in man. J Clin Invest 44:1042 (Abstract)
31. Havel RJ, Kane JP, Segel EO, Basso LV 1970 Splanchnic metabolism of free fatty acids and production of triglyceride of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans. J Clin Invest 49:2017-2035
32. Kissebah AH, Alfarsi S, Adams PW, Seed M, Folkard J, Wynn V 1976 Transport kinetics of plasma free fatty acid, very low density lipoprotein triglycerides and apoprotein in patients with endogenous hypertriglyceridaemia. Atherosclerosis 24:199-218
33. Frayn KN, Kingman SM 1995 Dietary sugars and lipid metabolism in humans. Am J Clin Nutr 62:250S-263S
34. Lewis GF 1997 Fatty acid regulation of very low density lipoprotein production. Curr Opin Lipidol 8:146-153
35. Minehira K, Tappy L, Chiolero R, Vladimirova V, Berger MM, Revelly JP, Schwarz JM 2002 Fractional hepatic de novo lipogenesis in healthy subjects during near-continuous oral nutrition and bed rest: a comparison with published data in artificially fed, critically ill patients. Clin Nutr 21:345-350
36. Barrows BR, Timlin MT, Parks EJ 2005 Spillover of dietary fatty acids and use of serum nonesterified fatty acids for the synthesis of VLDL-triacylglycerol under two different feeding regimens. Diabetes 54:2668-2673
37. Timlin MT, Barrows BR, Parks EJ 2005 Increased dietary substrate delivery alters hepatic fatty acid recycling in healthy men. Diabetes 54:2694-2701
38. Teusink B, Voshol PJ, Kahlmans VEH, Rensen PCN, Pijl H, Romijn JA, Havekes LM 2003 Contribution of fatty acids released from lipolysis of plasma triglycerides to total plasma fatty acid flux and tissue-specific fatty acid uptake. Diabetes 52:614-620
39. Xiang SQ, Cianflone K, Kalant D, Sniderman AD 1999 Differential binding of triglyceride-rich lipoproteins to lipoprotein lipase. J Lipid Res 40:1655-1662
40. Chen YI, Golay A, Swislocki ALM, Reaven GM 1987 Resistance to insulin suppression of plasma free fatty acid concentrations and insulin stimulation of glucose uptake in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 64:17-21
41. Kooner JS, Baliga RR, Wilding J, Crook D, Packard CJ, Banks LM, Peart S, Aitman TJ, Scott J 1998 Abdominal obesity, impaired nonesterified fatty acid suppression, and insulin-mediated glucose disposal are early metabolic abnormalities in families with premature myocardial infarction. Arterioscler Thromb Vasc Biol 18:1021-1026