Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease

Journal of Biological Chemistry

Volumn 286, Issue 43, 2011, Pages 37085-37093

  Huang, Yongcheng ^a,b   Cohen, Jonathan C ^a   Hobbs, Helen H ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL MOIETY; BIOLOGICAL SUBSTRATES; CHOLESTERYL ESTERS; DIACYLGLYCEROL; ENZYMATIC ACTIVITIES; GENETIC VARIANTS; GLYCEROPHOSPHATE; HYDROLYTIC ACTIVITIES; ISOFORMS; LYSOPHOSPHATIDIC ACID; MUTANT ENZYMES; NON-ALCOHOLIC FATTY LIVER DISEASE; PHOSPHOLIPASES; RETINYL ESTER; SERINE PROTEASE; SUBSTRATE SPECIFICITY; THIOESTERASES; TRIACYLGLYCEROLS; TRIOLEIN; WILD TYPES;

AMINO ACIDS; CATALYSIS; CATALYST ACTIVITY; ENZYMES; ESTERIFICATION; ESTERS; GLYCEROL; HYDROLYSIS; OLEIC ACID; PHOSPHOLIPIDS; PLANTS (BOTANY); PURIFICATION; UNSATURATED FATTY ACIDS;

SUBSTRATES;

CHOLESTEROL ESTER; DIACYLGLYCEROL; GLYCEROPHOSPHATE; ISOLEUCINE; ISOPROTEIN; LYSOPHOSPHATIDIC ACID; METHIONINE; MONOACYLGLYCEROL; OLEIC ACID; OLEOYL COENZYME A; PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 PROTEIN; PHOSPHOLIPID; PROTEIN I148M; RETINOL ESTER; SERINE; THIOL ESTER HYDROLASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; FAT CONTENT; FATTY ACID ANALYSIS; FATTY ACID TRANSPORT; HUMAN; HUMAN CELL; LIPID HYDROLYSIS; LIPID METABOLISM; LIPOGENESIS; LOSS OF FUNCTION MUTATION; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; SUBSTITUTION REACTION; WILD TYPE;

ACYL COENZYME A; AMINO ACID SUBSTITUTION; CELL LINE; FATTY LIVER; HUMANS; HYDROLYSIS; ISOENZYMES; LIPASE; MEMBRANE PROTEINS; MUTATION, MISSENSE; PHOSPHOLIPIDS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TRIGLYCERIDES;

EID: 80054806707     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.290114     Document Type: Article

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