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Volumn 16, Issue 3, 2012, Pages 505-524

Mechanisms of simple hepatic steatosis: Not so simple after all

Author keywords

Hepatic steatosis; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Triglycerides

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADIPONECTIN; ADRENALIN; CARNITINE PALMITOYLTRANSFERASE I; CHYLOMICRON; DIACYLGLYCEROL; FATTY ACID; FATTY ACID SYNTHASE; GLUCOSE; GLYCOGEN; INFLIXIMAB; INSULIN; INTERLEUKIN 6; LIPOPROTEIN LIPASE; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; MALONYL COENZYME A; MICRORNA 122; MICRORNA 124; MICRORNA 143; MICRORNA 375; NORADRENALIN; OLEIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; VERY LOW DENSITY LIPOPROTEIN;

EID: 84864090834     PISSN: 10893261     EISSN: 15578224     Source Type: Journal    
DOI: 10.1016/j.cld.2012.05.005     Document Type: Review
Times cited : (25)

References (97)
  • 1
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002, 346:1221-1231.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 2
    • 35348955284 scopus 로고    scopus 로고
    • Development and physiological regulation of intestinal lipid absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons
    • Mansbach C.M., Gorelick F. Development and physiological regulation of intestinal lipid absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons. Am J Physiol Gastrointest Liver Physiol 2007, 293:G645-G650.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.293
    • Mansbach, C.M.1    Gorelick, F.2
  • 3
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: old questions and new insights
    • Cohen J.C., Horton J.D., Hobbs H.H. Human fatty liver disease: old questions and new insights. Science 2011, 332:1519-1523.
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 4
    • 43849110089 scopus 로고    scopus 로고
    • Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome
    • Macfarlane D.P., Forbes S., Walker B.R. Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome. J Endocrinol 2008, 197:189-204.
    • (2008) J Endocrinol , vol.197 , pp. 189-204
    • Macfarlane, D.P.1    Forbes, S.2    Walker, B.R.3
  • 5
    • 0017738601 scopus 로고
    • A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis
    • McGarry J.D., Mannaerts G.P., Foster D.W. A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. J Clin Invest 1977, 60:265-270.
    • (1977) J Clin Invest , vol.60 , pp. 265-270
    • McGarry, J.D.1    Mannaerts, G.P.2    Foster, D.W.3
  • 6
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly K.L., Smith C.I., Schwarzenberg S.J., et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005, 115:1343-1351.
    • (2005) J Clin Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3
  • 7
    • 40549135297 scopus 로고    scopus 로고
    • Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
    • Postic C., Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest 2008, 118:829-838.
    • (2008) J Clin Invest , vol.118 , pp. 829-838
    • Postic, C.1    Girard, J.2
  • 8
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • Browning J.D., Horton J.D. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 2004, 114:147-152.
    • (2004) J Clin Invest , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 9
    • 0031887281 scopus 로고    scopus 로고
    • Role of human liver lipogenesis and reesterification in triglycerides secretion and in FFA reesterification
    • Diraison F., Beylot M. Role of human liver lipogenesis and reesterification in triglycerides secretion and in FFA reesterification. Am J Physiol 1998, 274:E321-E327.
    • (1998) Am J Physiol , vol.274
    • Diraison, F.1    Beylot, M.2
  • 10
    • 2942706241 scopus 로고    scopus 로고
    • Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    • Araya J., Rodrigo R., Videla L.A., et al. Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin Sci (Lond) 2004, 106:635-643.
    • (2004) Clin Sci (Lond) , vol.106 , pp. 635-643
    • Araya, J.1    Rodrigo, R.2    Videla, L.A.3
  • 11
    • 36349024819 scopus 로고    scopus 로고
    • A lipidomic analysis of nonalcoholic fatty liver disease
    • Puri P., Baillie R.A., Wiest M.M., et al. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology 2007, 46:1081-1090.
    • (2007) Hepatology , vol.46 , pp. 1081-1090
    • Puri, P.1    Baillie, R.A.2    Wiest, M.M.3
  • 12
    • 0030941803 scopus 로고    scopus 로고
    • The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    • Brown M.S., Goldstein J.L. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997, 89:331-340.
    • (1997) Cell , vol.89 , pp. 331-340
    • Brown, M.S.1    Goldstein, J.L.2
  • 13
    • 0142027805 scopus 로고    scopus 로고
    • Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
    • Horton J.D., Shah N.A., Warrington J.A., et al. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci U S A 2003, 100:12027-12032.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12027-12032
    • Horton, J.D.1    Shah, N.A.2    Warrington, J.A.3
  • 14
    • 0035977004 scopus 로고    scopus 로고
    • Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins
    • Moon Y.A., Shah N.A., Mohapatra S., et al. Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins. J Biol Chem 2001, 276:45358-45366.
    • (2001) J Biol Chem , vol.276 , pp. 45358-45366
    • Moon, Y.A.1    Shah, N.A.2    Mohapatra, S.3
  • 15
    • 34347402636 scopus 로고    scopus 로고
    • Regulation of triglyceride metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action
    • Gonzalez-Baro M.R., Lewin T.M., Coleman R.A. Regulation of triglyceride metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action. Am J Physiol Gastrointest Liver Physiol 2007, 292:G1195-G1199.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292
    • Gonzalez-Baro, M.R.1    Lewin, T.M.2    Coleman, R.A.3
  • 16
    • 0033609775 scopus 로고    scopus 로고
    • Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription
    • Sato R., Miyamoto W., Inoue J., et al. Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription. J Biol Chem 1999, 274:24714-24720.
    • (1999) J Biol Chem , vol.274 , pp. 24714-24720
    • Sato, R.1    Miyamoto, W.2    Inoue, J.3
  • 17
    • 0035860743 scopus 로고    scopus 로고
    • Sterol regulatory element-binding protein-1c mimics the negative effect of insulin on phosphoenolpyruvate carboxykinase (GTP) gene transcription
    • Chakravarty K., Leahy P., Becard D., et al. Sterol regulatory element-binding protein-1c mimics the negative effect of insulin on phosphoenolpyruvate carboxykinase (GTP) gene transcription. J Biol Chem 2001, 276:34816-34823.
    • (2001) J Biol Chem , vol.276 , pp. 34816-34823
    • Chakravarty, K.1    Leahy, P.2    Becard, D.3
  • 18
    • 0033570119 scopus 로고    scopus 로고
    • Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus
    • Shimomura I., Bashmakov Y., Horton J.D. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem 1999, 274:30028-30032.
    • (1999) J Biol Chem , vol.274 , pp. 30028-30032
    • Shimomura, I.1    Bashmakov, Y.2    Horton, J.D.3
  • 19
    • 0036213141 scopus 로고    scopus 로고
    • Dietary polyunsaturated fatty acids and regulation of gene transcription
    • Jump D.B. Dietary polyunsaturated fatty acids and regulation of gene transcription. Curr Opin Lipidol 2002, 13:155-164.
    • (2002) Curr Opin Lipidol , vol.13 , pp. 155-164
    • Jump, D.B.1
  • 20
    • 0035979214 scopus 로고    scopus 로고
    • A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver
    • Yamashita H., Takenoshita M., Sakurai M., et al. A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver. Proc Natl Acad Sci U S A 2001, 98:9116-9121.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 9116-9121
    • Yamashita, H.1    Takenoshita, M.2    Sakurai, M.3
  • 21
    • 0035923516 scopus 로고    scopus 로고
    • Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein
    • Kawaguchi T., Takenoshita M., Kabashima T., et al. Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein. Proc Natl Acad Sci U S A 2001, 98:13710-13715.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 13710-13715
    • Kawaguchi, T.1    Takenoshita, M.2    Kabashima, T.3
  • 22
    • 27844566646 scopus 로고    scopus 로고
    • Glucose as a regulator of eukaryotic gene transcription
    • Towle H.C. Glucose as a regulator of eukaryotic gene transcription. Trends Endocrinol Metab 2005, 16:489-494.
    • (2005) Trends Endocrinol Metab , vol.16 , pp. 489-494
    • Towle, H.C.1
  • 23
    • 2442435802 scopus 로고    scopus 로고
    • Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis
    • Iizuka K., Bruick R.K., Liang G., et al. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci U S A 2004, 101:7281-7286.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 7281-7286
    • Iizuka, K.1    Bruick, R.K.2    Liang, G.3
  • 24
    • 33749407193 scopus 로고    scopus 로고
    • ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver
    • Ma L., Robinson L.N., Towle H.C. ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver. J Biol Chem 2006, 281:28721-28730.
    • (2006) J Biol Chem , vol.281 , pp. 28721-28730
    • Ma, L.1    Robinson, L.N.2    Towle, H.C.3
  • 25
    • 84862960331 scopus 로고    scopus 로고
    • Liver X receptors bridge hepatic lipid metabolism and inflammation
    • Liu Y., Qiu de K., Ma X. Liver X receptors bridge hepatic lipid metabolism and inflammation. J Dig Dis 2012, 13:69-74.
    • (2012) J Dig Dis , vol.13 , pp. 69-74
    • Liu, Y.1    Qiu de, K.2    Ma, X.3
  • 26
    • 70450204007 scopus 로고    scopus 로고
    • An emerging role of mTOR in lipid biosynthesis
    • Laplante M., Sabatini D.M. An emerging role of mTOR in lipid biosynthesis. Curr Biol 2009, 19:R1046-R1052.
    • (2009) Curr Biol , vol.19
    • Laplante, M.1    Sabatini, D.M.2
  • 27
    • 0034669025 scopus 로고    scopus 로고
    • Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
    • Repa J.J., Liang G., Ou J., et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev 2000, 14:2819-2830.
    • (2000) Genes Dev , vol.14 , pp. 2819-2830
    • Repa, J.J.1    Liang, G.2    Ou, J.3
  • 28
    • 33847006599 scopus 로고    scopus 로고
    • The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR
    • Cha J.Y., Repa J.J. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem 2007, 282:743-751.
    • (2007) J Biol Chem , vol.282 , pp. 743-751
    • Cha, J.Y.1    Repa, J.J.2
  • 29
    • 79961239382 scopus 로고    scopus 로고
    • Lipid-sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome
    • Vacca M., Degirolamo C., Mariani-Costantini R., et al. Lipid-sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome. Wiley Interdiscip Rev Syst Biol Med 2011, 3:562-587.
    • (2011) Wiley Interdiscip Rev Syst Biol Med , vol.3 , pp. 562-587
    • Vacca, M.1    Degirolamo, C.2    Mariani-Costantini, R.3
  • 30
    • 33846208252 scopus 로고    scopus 로고
    • The nuclear receptor LXR is a glucose sensor
    • Mitro N., Mak P.A., Vargas L., et al. The nuclear receptor LXR is a glucose sensor. Nature 2007, 445:219-223.
    • (2007) Nature , vol.445 , pp. 219-223
    • Mitro, N.1    Mak, P.A.2    Vargas, L.3
  • 31
    • 76449100708 scopus 로고    scopus 로고
    • PPARs: diverse regulators in energy metabolism and metabolic diseases
    • Wang Y.X. PPARs: diverse regulators in energy metabolism and metabolic diseases. Cell Res 2010, 20:124-137.
    • (2010) Cell Res , vol.20 , pp. 124-137
    • Wang, Y.X.1
  • 32
    • 79957970349 scopus 로고    scopus 로고
    • Comparative gene expression profiles induced by PPARgamma and PPARalpha/gamma agonists in rat hepatocytes
    • Rogue A., Renaud M.P., Claude N., et al. Comparative gene expression profiles induced by PPARgamma and PPARalpha/gamma agonists in rat hepatocytes. Toxicol Appl Pharmacol 2011, 254:18-31.
    • (2011) Toxicol Appl Pharmacol , vol.254 , pp. 18-31
    • Rogue, A.1    Renaud, M.P.2    Claude, N.3
  • 33
    • 0032491614 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis
    • Costet P., Legendre C., More J., et al. Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. J Biol Chem 1998, 273:29577-29585.
    • (1998) J Biol Chem , vol.273 , pp. 29577-29585
    • Costet, P.1    Legendre, C.2    More, J.3
  • 34
    • 33947728699 scopus 로고    scopus 로고
    • Effects of a potent and selective PPAR-alpha agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: two randomized controlled trials
    • Nissen S.E., Nicholls S.J., Wolski K., et al. Effects of a potent and selective PPAR-alpha agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: two randomized controlled trials. JAMA 2007, 297:1362-1373.
    • (2007) JAMA , vol.297 , pp. 1362-1373
    • Nissen, S.E.1    Nicholls, S.J.2    Wolski, K.3
  • 35
    • 33644645013 scopus 로고    scopus 로고
    • PPAR delta: a dagger in the heart of the metabolic syndrome
    • Barish G.D., Narkar V.A., Evans R.M. PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest 2006, 116:590-597.
    • (2006) J Clin Invest , vol.116 , pp. 590-597
    • Barish, G.D.1    Narkar, V.A.2    Evans, R.M.3
  • 36
    • 0033708410 scopus 로고    scopus 로고
    • Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones
    • Chao L., Marcus-Samuels B., Mason M.M., et al. Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones. J Clin Invest 2000, 106:1221-1228.
    • (2000) J Clin Invest , vol.106 , pp. 1221-1228
    • Chao, L.1    Marcus-Samuels, B.2    Mason, M.M.3
  • 37
    • 0030985318 scopus 로고    scopus 로고
    • Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
    • Krey G., Braissant O., L'Horset F., et al. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol Endocrinol 1997, 11:779-791.
    • (1997) Mol Endocrinol , vol.11 , pp. 779-791
    • Krey, G.1    Braissant, O.2    L'Horset, F.3
  • 38
    • 0032516081 scopus 로고    scopus 로고
    • ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand
    • Kim J.B., Wright H.M., Wright M., et al. ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand. Proc Natl Acad Sci U S A 1998, 95:4333-4337.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 4333-4337
    • Kim, J.B.1    Wright, H.M.2    Wright, M.3
  • 39
    • 23444431623 scopus 로고    scopus 로고
    • Retinoid x receptor heterodimers in the metabolic syndrome
    • Shulman A.I., Mangelsdorf D.J. Retinoid x receptor heterodimers in the metabolic syndrome. N Engl J Med 2005, 353:604-615.
    • (2005) N Engl J Med , vol.353 , pp. 604-615
    • Shulman, A.I.1    Mangelsdorf, D.J.2
  • 40
    • 0035462629 scopus 로고    scopus 로고
    • PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein
    • Maeda N., Takahashi M., Funahashi T., et al. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 2001, 50:2094-2099.
    • (2001) Diabetes , vol.50 , pp. 2094-2099
    • Maeda, N.1    Takahashi, M.2    Funahashi, T.3
  • 41
    • 0344081177 scopus 로고    scopus 로고
    • Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status
    • Hardie D.G. Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology 2003, 144:5179-5183.
    • (2003) Endocrinology , vol.144 , pp. 5179-5183
    • Hardie, D.G.1
  • 42
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G., Myers R., Li Y., et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001, 108:1167-1174.
    • (2001) J Clin Invest , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3
  • 43
    • 0037040185 scopus 로고    scopus 로고
    • Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase
    • Kawaguchi T., Osatomi K., Yamashita H., et al. Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. J Biol Chem 2002, 277:3829-3835.
    • (2002) J Biol Chem , vol.277 , pp. 3829-3835
    • Kawaguchi, T.1    Osatomi, K.2    Yamashita, H.3
  • 44
    • 0035084699 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
    • Sanyal A.J., Campbell-Sargent C., Mirshahi F., et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001, 120:1183-1192.
    • (2001) Gastroenterology , vol.120 , pp. 1183-1192
    • Sanyal, A.J.1    Campbell-Sargent, C.2    Mirshahi, F.3
  • 45
    • 18244385511 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association
    • Pagano G., Pacini G., Musso G., et al. Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association. Hepatology 2002, 35:367-372.
    • (2002) Hepatology , vol.35 , pp. 367-372
    • Pagano, G.1    Pacini, G.2    Musso, G.3
  • 46
    • 18244364864 scopus 로고    scopus 로고
    • NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome
    • Chitturi S., Abeygunasekera S., Farrell G.C., et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002, 35:373-379.
    • (2002) Hepatology , vol.35 , pp. 373-379
    • Chitturi, S.1    Abeygunasekera, S.2    Farrell, G.C.3
  • 47
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • Weisberg S.P., McCann D., Desai M., et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003, 112:1796-1808.
    • (2003) J Clin Invest , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1    McCann, D.2    Desai, M.3
  • 48
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H., Barnes G.T., Yang Q., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003, 112:1821-1830.
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3
  • 49
    • 0042328038 scopus 로고    scopus 로고
    • Is obesity an inflammatory disease?
    • Ramos E.J., Xu Y., Romanova I., et al. Is obesity an inflammatory disease?. Surgery 2003, 134:329-335.
    • (2003) Surgery , vol.134 , pp. 329-335
    • Ramos, E.J.1    Xu, Y.2    Romanova, I.3
  • 50
    • 70350188297 scopus 로고    scopus 로고
    • Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome
    • Maury E., Brichard S.M. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol 2010, 314:1-16.
    • (2010) Mol Cell Endocrinol , vol.314 , pp. 1-16
    • Maury, E.1    Brichard, S.M.2
  • 52
    • 37349006913 scopus 로고    scopus 로고
    • TNF-alpha and adipocyte biology
    • Cawthorn W.P., Sethi J.K. TNF-alpha and adipocyte biology. FEBS Lett 2008, 582:117-131.
    • (2008) FEBS Lett , vol.582 , pp. 117-131
    • Cawthorn, W.P.1    Sethi, J.K.2
  • 53
    • 57349101675 scopus 로고    scopus 로고
    • A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
    • Sabio G., Das M., Mora A., et al. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 2008, 322:1539-1543.
    • (2008) Science , vol.322 , pp. 1539-1543
    • Sabio, G.1    Das, M.2    Mora, A.3
  • 54
    • 3042744737 scopus 로고    scopus 로고
    • Beyond insulin resistance in NASH: TNF-alpha or adiponectin?
    • Hui J.M., Hodge A., Farrell G.C., et al. Beyond insulin resistance in NASH: TNF-alpha or adiponectin?. Hepatology 2004, 40:46-54.
    • (2004) Hepatology , vol.40 , pp. 46-54
    • Hui, J.M.1    Hodge, A.2    Farrell, G.C.3
  • 55
    • 34748903504 scopus 로고    scopus 로고
    • Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet
    • Barbuio R., Milanski M., Bertolo M.B., et al. Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet. J Endocrinol 2007, 194:539-550.
    • (2007) J Endocrinol , vol.194 , pp. 539-550
    • Barbuio, R.1    Milanski, M.2    Bertolo, M.B.3
  • 56
    • 33846867939 scopus 로고    scopus 로고
    • Point-counterpoint: interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis
    • [author reply: 825]
    • Bastard J.P., Lagathu C., Caron M., et al. Point-counterpoint: interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis. J Appl Physiol 2007, 102:821-822. [author reply: 825].
    • (2007) J Appl Physiol , vol.102 , pp. 821-822
    • Bastard, J.P.1    Lagathu, C.2    Caron, M.3
  • 57
    • 34247130827 scopus 로고    scopus 로고
    • Physiological roles of muscle-derived interleukin-6 in response to exercise
    • Pedersen B.K., Fischer C.P. Physiological roles of muscle-derived interleukin-6 in response to exercise. Curr Opin Clin Nutr Metab Care 2007, 10:265-271.
    • (2007) Curr Opin Clin Nutr Metab Care , vol.10 , pp. 265-271
    • Pedersen, B.K.1    Fischer, C.P.2
  • 58
    • 17844393870 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT
    • Bruun J.M., Lihn A.S., Pedersen S.B., et al. Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT. J Clin Endocrinol Metab 2005, 90:2282-2289.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2282-2289
    • Bruun, J.M.1    Lihn, A.S.2    Pedersen, S.B.3
  • 59
    • 33745216724 scopus 로고    scopus 로고
    • MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    • Kanda H., Tateya S., Tamori Y., et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 2006, 116:1494-1505.
    • (2006) J Clin Invest , vol.116 , pp. 1494-1505
    • Kanda, H.1    Tateya, S.2    Tamori, Y.3
  • 60
    • 34248343425 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1, adipose tissue and insulin resistance
    • Alessi M.C., Poggi M., Juhan-Vague I. Plasminogen activator inhibitor-1, adipose tissue and insulin resistance. Curr Opin Lipidol 2007, 18:240-245.
    • (2007) Curr Opin Lipidol , vol.18 , pp. 240-245
    • Alessi, M.C.1    Poggi, M.2    Juhan-Vague, I.3
  • 61
    • 10744228409 scopus 로고    scopus 로고
    • Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1
    • Ma L.J., Mao S.L., Taylor K.L., et al. Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. Diabetes 2004, 53:336-346.
    • (2004) Diabetes , vol.53 , pp. 336-346
    • Ma, L.J.1    Mao, S.L.2    Taylor, K.L.3
  • 62
    • 22944434929 scopus 로고    scopus 로고
    • Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
    • Yang Q., Graham T.E., Mody N., et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 2005, 436:356-362.
    • (2005) Nature , vol.436 , pp. 356-362
    • Yang, Q.1    Graham, T.E.2    Mody, N.3
  • 63
    • 38349135373 scopus 로고    scopus 로고
    • Serum retinol binding protein 4 and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus
    • Wu H., Jia W., Bao Y., et al. Serum retinol binding protein 4 and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 2008, 79:185-190.
    • (2008) Diabetes Res Clin Pract , vol.79 , pp. 185-190
    • Wu, H.1    Jia, W.2    Bao, Y.3
  • 64
    • 33644825288 scopus 로고    scopus 로고
    • Increased serum resistin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistance
    • Pagano C., Soardo G., Pilon C., et al. Increased serum resistin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistance. J Clin Endocrinol Metab 2006, 91:1081-1086.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1081-1086
    • Pagano, C.1    Soardo, G.2    Pilon, C.3
  • 65
    • 1542570269 scopus 로고    scopus 로고
    • Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine
    • Yamauchi T., Hara K., Kubota N., et al. Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine. Curr Drug Targets Immune Endocr Metabol Disord 2003, 3:243-254.
    • (2003) Curr Drug Targets Immune Endocr Metabol Disord , vol.3 , pp. 243-254
    • Yamauchi, T.1    Hara, K.2    Kubota, N.3
  • 66
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • Kadowaki T., Yamauchi T., Kubota N., et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 2006, 116:1784-1792.
    • (2006) J Clin Invest , vol.116 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3
  • 67
    • 33947627537 scopus 로고    scopus 로고
    • Adiponectin as an anti-inflammatory factor
    • Ouchi N., Walsh K. Adiponectin as an anti-inflammatory factor. Clin Chim Acta 2007, 380:24-30.
    • (2007) Clin Chim Acta , vol.380 , pp. 24-30
    • Ouchi, N.1    Walsh, K.2
  • 68
    • 0034641647 scopus 로고    scopus 로고
    • Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway
    • Ouchi N., Kihara S., Arita Y., et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 2000, 102:1296-1301.
    • (2000) Circulation , vol.102 , pp. 1296-1301
    • Ouchi, N.1    Kihara, S.2    Arita, Y.3
  • 69
    • 0842332231 scopus 로고    scopus 로고
    • Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL
    • Motoshima H., Wu X., Mahadev K., et al. Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL. Biochem Biophys Res Commun 2004, 315:264-271.
    • (2004) Biochem Biophys Res Commun , vol.315 , pp. 264-271
    • Motoshima, H.1    Wu, X.2    Mahadev, K.3
  • 70
    • 13444274359 scopus 로고    scopus 로고
    • Plasma adiponectin decrease in women with nonalcoholic fatty liver
    • Matsubara M. Plasma adiponectin decrease in women with nonalcoholic fatty liver. Endocr J 2004, 51:587-593.
    • (2004) Endocr J , vol.51 , pp. 587-593
    • Matsubara, M.1
  • 71
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • Xu A., Wang Y., Keshaw H., et al. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 2003, 112:91-100.
    • (2003) J Clin Invest , vol.112 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3
  • 72
    • 0037148928 scopus 로고    scopus 로고
    • Leptin-replacement therapy for lipodystrophy
    • Oral E.A., Simha V., Ruiz E., et al. Leptin-replacement therapy for lipodystrophy. N Engl J Med 2002, 346:570-578.
    • (2002) N Engl J Med , vol.346 , pp. 570-578
    • Oral, E.A.1    Simha, V.2    Ruiz, E.3
  • 73
    • 84855894410 scopus 로고    scopus 로고
    • Association of nonalcoholic fatty liver disease with a single nucleotide polymorphism on the gene encoding leptin receptor
    • Swellam M., Hamdy N. Association of nonalcoholic fatty liver disease with a single nucleotide polymorphism on the gene encoding leptin receptor. IUBMB Life 2012, 64:180-186.
    • (2012) IUBMB Life , vol.64 , pp. 180-186
    • Swellam, M.1    Hamdy, N.2
  • 74
    • 0036217052 scopus 로고    scopus 로고
    • Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
    • Lewis G.F., Carpentier A., Adeli K., et al. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 2002, 23:201-229.
    • (2002) Endocr Rev , vol.23 , pp. 201-229
    • Lewis, G.F.1    Carpentier, A.2    Adeli, K.3
  • 75
    • 32444451567 scopus 로고    scopus 로고
    • Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion
    • Wolfrum C., Stoffel M. Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion. Cell Metab 2006, 3:99-110.
    • (2006) Cell Metab , vol.3 , pp. 99-110
    • Wolfrum, C.1    Stoffel, M.2
  • 76
    • 11144244418 scopus 로고    scopus 로고
    • Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes
    • Wolfrum C., Asilmaz E., Luca E., et al. Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature 2004, 432:1027-1032.
    • (2004) Nature , vol.432 , pp. 1027-1032
    • Wolfrum, C.1    Asilmaz, E.2    Luca, E.3
  • 77
    • 12144279575 scopus 로고    scopus 로고
    • Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance
    • Kabir M., Catalano K.J., Ananthnarayan S., et al. Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance. Am J Physiol Endocrinol Metab 2005, 288:E454-E461.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Kabir, M.1    Catalano, K.J.2    Ananthnarayan, S.3
  • 78
    • 3543029821 scopus 로고    scopus 로고
    • Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
    • Samuel V.T., Liu Z.X., Qu X., et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 2004, 279:32345-32353.
    • (2004) J Biol Chem , vol.279 , pp. 32345-32353
    • Samuel, V.T.1    Liu, Z.X.2    Qu, X.3
  • 79
    • 38649116056 scopus 로고    scopus 로고
    • Selective versus total insulin resistance: a pathogenic paradox
    • Brown M.S., Goldstein J.L. Selective versus total insulin resistance: a pathogenic paradox. Cell Metab 2008, 7:95-96.
    • (2008) Cell Metab , vol.7 , pp. 95-96
    • Brown, M.S.1    Goldstein, J.L.2
  • 80
    • 65249188812 scopus 로고    scopus 로고
    • Heritability of nonalcoholic fatty liver disease
    • Schwimmer J.B., Celedon M.A., Lavine J.E., et al. Heritability of nonalcoholic fatty liver disease. Gastroenterology 2009, 136:1585-1592.
    • (2009) Gastroenterology , vol.136 , pp. 1585-1592
    • Schwimmer, J.B.1    Celedon, M.A.2    Lavine, J.E.3
  • 81
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    • Browning J.D., Szczepaniak L.S., Dobbins R., et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004, 40:1387-1395.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3
  • 82
    • 33845315534 scopus 로고    scopus 로고
    • Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men
    • Petersen K.F., Dufour S., Feng J., et al. Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proc Natl Acad Sci U S A 2006, 103:18273-18277.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 18273-18277
    • Petersen, K.F.1    Dufour, S.2    Feng, J.3
  • 83
    • 77956630787 scopus 로고    scopus 로고
    • PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease
    • Speliotes E.K., Butler J.L., Palmer C.D., et al. PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease. Hepatology 2010, 52:904-912.
    • (2010) Hepatology , vol.52 , pp. 904-912
    • Speliotes, E.K.1    Butler, J.L.2    Palmer, C.D.3
  • 84
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S., Kozlitina J., Xing C., et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008, 40:1461-1465.
    • (2008) Nat Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3
  • 85
    • 77952409634 scopus 로고    scopus 로고
    • A feed-forward loop amplifies nutritional regulation of PNPLA3
    • Huang Y., He S., Li J.Z., et al. A feed-forward loop amplifies nutritional regulation of PNPLA3. Proc Natl Acad Sci U S A 2010, 107:7892-7897.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 7892-7897
    • Huang, Y.1    He, S.2    Li, J.Z.3
  • 86
    • 77949895032 scopus 로고    scopus 로고
    • A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis
    • He S., McPhaul C., Li J.Z., et al. A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J Biol Chem 2010, 285:6706-6715.
    • (2010) J Biol Chem , vol.285 , pp. 6706-6715
    • He, S.1    McPhaul, C.2    Li, J.Z.3
  • 87
    • 20944436157 scopus 로고    scopus 로고
    • Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
    • Osei-Hyiaman D., DePetrillo M., Pacher P., et al. Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J Clin Invest 2005, 115:1298-1305.
    • (2005) J Clin Invest , vol.115 , pp. 1298-1305
    • Osei-Hyiaman, D.1    DePetrillo, M.2    Pacher, P.3
  • 88
    • 78751551237 scopus 로고    scopus 로고
    • Endocannabinoids in liver disease
    • Tam J., Liu J., Mukhopadhyay B., et al. Endocannabinoids in liver disease. Hepatology 2011, 53:346-355.
    • (2011) Hepatology , vol.53 , pp. 346-355
    • Tam, J.1    Liu, J.2    Mukhopadhyay, B.3
  • 89
    • 77956627688 scopus 로고    scopus 로고
    • Fructose: metabolic, hedonic, and societal parallels with ethanol
    • Lustig R.H. Fructose: metabolic, hedonic, and societal parallels with ethanol. J Am Diet Assoc 2010, 110:1307-1321.
    • (2010) J Am Diet Assoc , vol.110 , pp. 1307-1321
    • Lustig, R.H.1
  • 90
    • 66449093225 scopus 로고    scopus 로고
    • Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
    • Stanhope K.L., Schwarz J.M., Keim N.L., et al. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 2009, 119:1322-1334.
    • (2009) J Clin Invest , vol.119 , pp. 1322-1334
    • Stanhope, K.L.1    Schwarz, J.M.2    Keim, N.L.3
  • 91
    • 78751646546 scopus 로고    scopus 로고
    • Fructose impairs glucose-induced hepatic triglyceride synthesis
    • Huang D., Dhawan T., Young S., et al. Fructose impairs glucose-induced hepatic triglyceride synthesis. Lipids Health Dis 2011, 10:20.
    • (2011) Lipids Health Dis , vol.10 , pp. 20
    • Huang, D.1    Dhawan, T.2    Young, S.3
  • 92
    • 58149386462 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis is associated with altered hepatic microRNA expression
    • Cheung O., Puri P., Eicken C., et al. Nonalcoholic steatohepatitis is associated with altered hepatic microRNA expression. Hepatology 2008, 48:1810-1820.
    • (2008) Hepatology , vol.48 , pp. 1810-1820
    • Cheung, O.1    Puri, P.2    Eicken, C.3
  • 93
    • 84858776574 scopus 로고    scopus 로고
    • MicroRNAs in metabolism and metabolic disorders
    • Rottiers V., Naar A.M. MicroRNAs in metabolism and metabolic disorders. Nat Rev Mol Cell Biol 2012, 13:1.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 1
    • Rottiers, V.1    Naar, A.M.2
  • 94
    • 8144226856 scopus 로고    scopus 로고
    • The gut microbiota as an environmental factor that regulates fat storage
    • Backhed F., Ding H., Wang T., et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 2004, 101:15718-15723.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 15718-15723
    • Backhed, F.1    Ding, H.2    Wang, T.3
  • 95
    • 57649214103 scopus 로고    scopus 로고
    • Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)
    • Musso G., Gambino R., Cassader M. Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Prog Lipid Res 2009, 48:1-26.
    • (2009) Prog Lipid Res , vol.48 , pp. 1-26
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 96
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh P.J., Ley R.E., Mahowald M.A., et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006, 444:1027-1031.
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3
  • 97
    • 79953161490 scopus 로고    scopus 로고
    • Effects of the gut microbiota on obesity and glucose homeostasis
    • Greiner T., Backhed F. Effects of the gut microbiota on obesity and glucose homeostasis. Trends Endocrinol Metab 2011, 22:117-123.
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 117-123
    • Greiner, T.1    Backhed, F.2


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