Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: The role of toll-like receptors 2 and 4

Alcoholism: Clinical and Experimental Research

Volumn 29, Issue 11 SUPPL., 2005, Pages

  Szabo, Gyongyi ^a   Velayudham, Arumugam ^a   Romics Jr , Laszlo ^a   Mandrekar, Pranoti ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

IL 12; IL 6; NF B; PPAR; TNF ; Toll Like Receptors

Indexed keywords

ALANINE AMINOTRANSFERASE; CHOLINE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; METHIONINE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIETARY INTAKE; FEMALE; LIVER INJURY; LIVER PROTECTION; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PATTERN RECOGNITION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROVOCATION TEST; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION; SPECIES COMPARISON; TEST MEAL;

ANIMALS; FATTY LIVER; FEMALE; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LIVER; MICE; MICE, MUTANT STRAINS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 32044438279     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.alc.0000189287.83544.33     Document Type: Conference Paper

References (30)

1. Akira S, Takeda K (2004) Toll-like receptor signaling. Nat Rev Immunol 4:499-511.
2. Akira S, Sato S (2003) Toll-like receptors and their signaling mechanisms. Scand J Infect Dis 35:555-562.
3. Angulo P (2002) Nonalcoholic fatty liver disease. N Engl J Med 346:1221-12231.
4. Boehme KM, Compton T (2004) Innate sensing of viruses by toll-like receptors. J Virol 78:7867-7873.
5. Clark RB (2002) The role of PPARs in inflammation and immunity. J Leukoc Biol 71:388-400.
6. Cressman DE, Greenbaum LE, Haber DE, Traub R (1994) Rapid activation of post-hepatectomy factor. NF-κB in hepatocytes, a primary response in the regenerating liver. J Biol Chem 269: 30429-30435.
7. Delerive P, DeBosscher K, Besnard S, VandenBerghe W, Peters JM, Gonzalez FJ, Fruchart JC, Tedgui A, Haegeman G, Staels B (1999) Peroxisome proliferator-actived receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1. J Biol Chem 274:32048-32054.
8. Hines IN, Wheeler D (2004) Recent advances in alcoholic liver disease. III. Role of the innate response in alcoholic hepatitis. Am J Physiol Gastrointest Liver Physiol 287:G310-G314.
9. Igolnikov AC, Spatz K, Green RM (2002) C3H/HEJ mice with mutations of the toll-like receptor 4 (TLR-4) are resistant to the methionine-choline deficient (MCD) diet induced non-alcoholic steatohepatitis (NASH). Hepatology 36:A404.
10. Ip E, Farrell G, Hall P, Robertson G, Leclercq I (2004) Administration of the potent PPARg agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice. Hepatology 39:1286-1296.
11. Iredale JP (2003) Regulating hepatic inflammation: pathogen-associated molecular patterns take their toll. Hepatology 37:979-981.
12. Kopp Medzhitov E (2003) Recognition of microbial infection by toll-like receptors. Curr Opin Immunol 15:396-401.
13. Liu S, Gallo DJ, Green AM, Williams DL, Gong X, Shapiro RA, Gambotto AA, Humphris EL, Vodovotz Y, Billiar TR (2002) Role of toll-like receptors in changes in gene expression and NF-κB activation in mouse hepatocytes stimulated with lipopolysaccharide. Infect Immun 70:3433-3442.
14. Martin-Armas M, Simon-SantaMaria J, Pettersen B, Smedsrod B, Sveionbjornsson B (2004) TLR9 is present in murine hepatic sinusoidal endothelial cells and mediates the effect of CpG (Abstract) Toll 2004 Taormina, Italy.
15. McClain CJ, Song Z, Barve SS, Hill DB, Deaciuc I (2004) Recent advances in alcoholic disease. IV. Dysregulated cytokine metabolism in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 287:G497-G502.
16. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C, Brenner DA (2003) Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 37:1043-1055.
17. Peters JM, Hennuyer N, Staels B, Fruchart JC, Fievet C, Gonzalez FJ, Auwerz J (1997) Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice. J Biol Chem 272:27307-27312.
18. Rao RK, Seth A, Sheth P (2004) Recent advances in alcoholic liver disease. I. Role of intestinal permeability and endotoxemia in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 286:G881-G884.
19. Ribeira PS, Cortez-Pinto H, Solá S, Castro RE, Ramalho RM, Baptista A, Moura MC, Camilo ME, Rodrigues CMP (2004) Hepatocyte apoptosis, expression of death receptors activation of NF-κB in the liver of non-alcoholic and alcoholic steatohepatitis patients. Am J Gastroenterol 99:1708-1717.
20. Ricote M, Li AC, Wilson TM, Kelly CJ, Glass CK (1998) The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391:79-82.
21. Romics Jr., L, Kodys K, Dolganiuc A, Graham L, Velayudham A, Mandrekar P, Szabo G (2004a) Diverse regulation of NF-kappaB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liver. Hepatology 40:376-385.
22. Romics Jr. L, Dolganiuc A, Kodys K, Drechsler Y, Oak S, Velayudham A, Mandrekar P, Szabo G (2004b) Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice. Hepatology 40:555-564.
23. Spiegelman BM (1998) PPAR-gamma: adipogenic regulates and thiazolidenedione receptor. Diabetes 47:507-514.
24. Su GL, Klein RD, Aminlari A, Zhang HY, Steinstraesser L, Alarcon WH, Remick DG, Wang SC (2000) Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4. Hepatology 31:932-936.
25. Sun A, Klein AS, Radaeva S, Hong F, El-Assal O, Pan HN, Jaruga B, Batkai S, Hoshino S, Tian Z, Kunos G, Diehl AM, Gao B (2003) In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats. Gastroenterology 125:256-259.
26. Szabo G, Chavan S, Mandrekar P, Catalano D (1999) Acute alcohol consumption attenuates IL-8 and MCP-1 induction in response to ex vivo stimulation. J Clin Immunol 19:67-76.
27. Takeda K, Akira S (2004) TLR signaling pathways. Semin Immunol 16:3-9.
28. Tilg H, Diehl A (2000) Cytokine in alcoholic and nonalcoholic steatohepatitis. N Engl J Med 343:1467-1476.
29. Yang SQ, Lin HZ, Lane MD, Clemens M, Diehl AM (1997) Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc Natl Acad Sci U S A 94:2557-2562.
30. Yang S, Lin H, Diehl AM (2001) Fatty liver vulnerability to endotoxin-induced damage despite NF-κB induction and inhibited caspase 3 activation. Am J Physiol Gastrointest Liver Physiol 281:G382-G392.