-
1
-
-
84860162767
-
Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis
-
doi: 10.1523/JNEUROSCI.5462-11.2012
-
Amiri, A., Cho, W., Zhou, J., Birnbaum, S. G., Sinton, C. M., McKay, R. M., et al. (2012). Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis. J. Neurosci. 32, 5880-5890. doi: 10.1523/JNEUROSCI.5462-11.2012
-
(2012)
J. Neurosci.
, vol.32
, pp. 5880-5890
-
-
Amiri, A.1
Cho, W.2
Zhou, J.3
Birnbaum, S.G.4
Sinton, C.M.5
McKay, R.M.6
-
2
-
-
34249910593
-
An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells
-
doi: 10.1083/jcb.200609017
-
Aoki, K., Nakamura, T., Inoue, T., Meyer, T., and Matsuda, M. (2007). An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells. J. Cell Biol. 177, 817-827. doi: 10.1083/jcb.200609017
-
(2007)
J. Cell Biol.
, vol.177
, pp. 817-827
-
-
Aoki, K.1
Nakamura, T.2
Inoue, T.3
Meyer, T.4
Matsuda, M.5
-
3
-
-
73949117548
-
PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane
-
doi: 10.1038/nn.2462
-
Arendt, K. L., Royo, M., Fernández-Monreal, M., Knafo, S., Petrok, C. N., Martens, J. R., et al. (2010). PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane. Nat. Neurosci. 13, 36-44. doi: 10.1038/nn.2462
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 36-44
-
-
Arendt, K.L.1
Royo, M.2
Fernández-Monreal, M.3
Knafo, S.4
Petrok, C.N.5
Martens, J.R.6
-
4
-
-
0035733762
-
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
-
doi: 10.1038/ng782
-
Backman, S. A., Stambolic, V., Suzuki, A., Haight, J., Elia, A., Pretorius, J., et al. (2001). Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat. Genet. 29, 396-403. doi: 10.1038/ng782
-
(2001)
Nat. Genet.
, vol.29
, pp. 396-403
-
-
Backman, S.A.1
Stambolic, V.2
Suzuki, A.3
Haight, J.4
Elia, A.5
Pretorius, J.6
-
5
-
-
84880710673
-
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress
-
doi: 10.1126/science.1236188
-
Bassi, C., Ho, J., Srikumar, T., Dowling, R. J. O., Gorrini, C., Miller, S. J., et al. (2013). Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress. Science 341, 395-399. doi: 10.1126/science.1236188
-
(2013)
Science
, vol.341
, pp. 395-399
-
-
Bassi, C.1
Ho, J.2
Srikumar, T.3
Dowling, R.J.O.4
Gorrini, C.5
Miller, S.J.6
-
6
-
-
84880124600
-
Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis
-
doi: 10.7554/eLife.00691
-
Bolduc, D., Rahdar, M., Tu-Sekine, B., Sivakumaren, S. C., Raben, D., Amzel, L. M., et al. (2013). Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis. Elife 2:e00691. doi: 10.7554/eLife.00691
-
(2013)
Elife
, vol.2
-
-
Bolduc, D.1
Rahdar, M.2
Tu-Sekine, B.3
Sivakumaren, S.C.4
Raben, D.5
Amzel, L.M.6
-
7
-
-
84887589243
-
Identification of PTEN at the ER and MAMs and its regulation of Ca(2+) signaling and apoptosis in a protein phosphatase-dependent manner
-
doi: 10.1038/cdd.2013.77
-
Bononi, A., Bonora, M., Marchi, S., Missiroli, S., Poletti, F., Giorgi, C., et al. (2013). Identification of PTEN at the ER and MAMs and its regulation of Ca(2+) signaling and apoptosis in a protein phosphatase-dependent manner. Cell Death Differ. 20, 1631-1643. doi: 10.1038/cdd.2013.77
-
(2013)
Cell Death Differ.
, vol.20
, pp. 1631-1643
-
-
Bononi, A.1
Bonora, M.2
Marchi, S.3
Missiroli, S.4
Poletti, F.5
Giorgi, C.6
-
8
-
-
20244367771
-
Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations
-
doi: 10.1136/jmg.2004.024646
-
Butler, M. G., Dasouki, M. J., Zhou, X.-P., Talebizadeh, Z., Brown, M., Takahashi, T. N., Miles, J. H., Wang, C. H., Stratton, R., Pilarski, R., et al. (2005). Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. J. Med. Genet. 42, 318-321. doi: 10.1136/jmg.2004.024646
-
(2005)
J. Med. Genet.
, vol.42
, pp. 318-321
-
-
Butler, M.G.1
Dasouki, M.J.2
Zhou, X.-P.3
Talebizadeh, Z.4
Brown, M.5
Takahashi, T.N.6
Miles, J.H.7
Wang, C.H.8
Stratton, R.9
Pilarski, R.10
-
9
-
-
34250812575
-
Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly
-
doi: 10.1002/ajmg.b.30493
-
Buxbaum, J. D., Cai, G., Chaste, P., Nygren, G., Goldsmith, J., Reichert, J., et al. (2007). Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B, 484-491. doi: 10.1002/ajmg.b.30493
-
(2007)
Am. J. Med. Genet. B Neuropsychiatr. Genet.
, vol.144 B
, pp. 484-491
-
-
Buxbaum, J.D.1
Cai, G.2
Chaste, P.3
Nygren, G.4
Goldsmith, J.5
Reichert, J.6
-
10
-
-
84882657764
-
MC1R is a potent regulator of PTEN after UV exposure in melanocytes
-
doi: 10.1016/j.molcel.2013.08.010
-
Cao, J., Wan, L., Hacker, E., Dai, X., Lenna, S., Jimenez-Cervantes, C., et al. (2013). MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Mol. Cell 51, 409-422. doi: 10.1016/j.molcel.2013.08.010
-
(2013)
Mol. Cell
, vol.51
, pp. 409-422
-
-
Cao, J.1
Wan, L.2
Hacker, E.3
Dai, X.4
Lenna, S.5
Jimenez-Cervantes, C.6
-
11
-
-
0036382931
-
Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1
-
doi: 10.1016/S0006-291X(02)00928-2
-
Caselli, A., Mazzinghi, B., Camici, G., Manao, G., and Ramponi, G. (2002). Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1. Biochem. Biophys. Res. Commun. 296, 692-697. doi: 10.1016/S0006-291X(02)00928-2
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.296
, pp. 692-697
-
-
Caselli, A.1
Mazzinghi, B.2
Camici, G.3
Manao, G.4
Ramponi, G.5
-
12
-
-
33645237488
-
PTEN couples Sema3A signalling to growth cone collapse
-
doi: 10.1242/jcs.02801
-
Chadborn, N. H., Ahmed, A. I., Holt, M. R., Prinjha, R., Dunn, G. A., Jones, G. E., et al. (2006). PTEN couples Sema3A signalling to growth cone collapse. J. Cell Sci. 119, 951-957. doi: 10.1242/jcs.02801
-
(2006)
J. Cell Sci.
, vol.119
, pp. 951-957
-
-
Chadborn, N.H.1
Ahmed, A.I.2
Holt, M.R.3
Prinjha, R.4
Dunn, G.A.5
Jones, G.E.6
-
13
-
-
77950440345
-
Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase
-
doi: 10.1073/pnas.0908899107
-
Chagpar, R. B., Links, P. H., Pastor, M. C., Furber, L. A., Hawrysh, A. D., Chamberlain, M. D., et al. (2010). Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. U.S.A. 107, 5471-5476. doi: 10.1073/pnas.0908899107
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 5471-5476
-
-
Chagpar, R.B.1
Links, P.H.2
Pastor, M.C.3
Furber, L.A.4
Hawrysh, A.D.5
Chamberlain, M.D.6
-
14
-
-
4143087008
-
Lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of PTEN in the detergent-resistant membrane fraction
-
doi: 10.1007/s00018-004-4127-7
-
Cheung, N. S., Choy, M. S., Halliwell, B., Teo, T. S., Bay, B. H., Lee, A. Y., et al. (2004). Lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of PTEN in the detergent-resistant membrane fraction. Cell Mol. Life Sci. 61, 1926-1934. doi: 10.1007/s00018-004-4127-7
-
(2004)
Cell Mol. Life Sci.
, vol.61
, pp. 1926-1934
-
-
Cheung, N.S.1
Choy, M.S.2
Halliwell, B.3
Teo, T.S.4
Bay, B.H.5
Lee, A.Y.6
-
15
-
-
84873173557
-
Exosomes as a novel way of interneuronal communication
-
doi: 10.1042/BST20120266
-
Chivet, M., Javalet, C., Hemming, F., Pernet-Gallay, K., Laulagnier, K., Fraboulet, S., et al. (2013). Exosomes as a novel way of interneuronal communication. Biochem. Soc. Trans. 41, 241-244. doi: 10.1042/BST20120266
-
(2013)
Biochem. Soc. Trans.
, vol.41
, pp. 241-244
-
-
Chivet, M.1
Javalet, C.2
Hemming, F.3
Pernet-Gallay, K.4
Laulagnier, K.5
Fraboulet, S.6
-
16
-
-
33746731609
-
PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis
-
doi: 10.1016/j.neulet.2006.06.037
-
Choy, M. S., Bay, B. H., Cheng, H. C., and Cheung, N. S. (2006). PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis. Neurosci. Lett. 405, 120-125. doi: 10.1016/j.neulet.2006.06.037
-
(2006)
Neurosci. Lett.
, vol.405
, pp. 120-125
-
-
Choy, M.S.1
Bay, B.H.2
Cheng, H.C.3
Cheung, N.S.4
-
17
-
-
77954480424
-
PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons
-
doi: 10.1523/JNEUROSCI.6271-09.2010
-
Christie, K. J., Webber, C. A., Martinez, J. A., Singh, B., and Zochodne, D. W. (2010). PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons. J. Neurosci. 30, 9306-9315. doi: 10.1523/JNEUROSCI.6271-09.2010
-
(2010)
J. Neurosci.
, vol.30
, pp. 9306-9315
-
-
Christie, K.J.1
Webber, C.A.2
Martinez, J.A.3
Singh, B.4
Zochodne, D.W.5
-
18
-
-
20144384760
-
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein
-
doi: 10.1158/0008-5472.CAN-05-0124
-
Chung, J.-H., Ginn-Pease, M. E., and Eng, C. (2005). Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein. Cancer Res. 65, 4108-4116. doi: 10.1158/0008-5472.CAN-05-0124
-
(2005)
Cancer Res.
, vol.65
, pp. 4108-4116
-
-
Chung, J.-H.1
Ginn-Pease, M.E.2
Eng, C.3
-
19
-
-
84858673050
-
Phosphatase and tensin homolog (PTEN) gene mutations and autism: Literature review and a case report of a patient with Cowden syndrome, autistic disorder, and epilepsy
-
doi: 10.1177/0883073811420296
-
Conti, S., Condò, M., Posar, A., Mari, F., Resta, N., Renieri, A., et al. (2012). Phosphatase and tensin homolog (PTEN) gene mutations and autism: literature review and a case report of a patient with Cowden syndrome, autistic disorder, and epilepsy. J. Child Neurol. 27, 392-397. doi: 10.1177/0883073811420296
-
(2012)
J. Child Neurol.
, vol.27
, pp. 392-397
-
-
Conti, S.1
Condò, M.2
Posar, A.3
Mari, F.4
Resta, N.5
Renieri, A.6
-
20
-
-
84886826594
-
mTOR complexes in neurodevelopmental and neuropsychiatric disorders
-
doi: 10.1038/nn.3546
-
Costa-Mattioli, M., and Monteggia, L. M. (2013). mTOR complexes in neurodevelopmental and neuropsychiatric disorders. Nat. Neurosci. 16, 1537-1543. doi: 10.1038/nn.3546
-
(2013)
Nat. Neurosci.
, vol.16
, pp. 1537-1543
-
-
Costa-Mattioli, M.1
Monteggia, L.M.2
-
21
-
-
70349168685
-
Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons
-
doi: 10.1371/journal.pone.0007027
-
Diaz-Ruiz, O., Zapata, A., Shan, L., Zhang, Y., Tomac, A. C., Malik, N., et al. (2009). Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons. PloS ONE 4:e7027. doi: 10.1371/journal.pone.0007027
-
(2009)
PloS ONE
, vol.4
-
-
Diaz-Ruiz, O.1
Zapata, A.2
Shan, L.3
Zhang, Y.4
Tomac, A.C.5
Malik, N.6
-
22
-
-
84896699377
-
Inhibition of phosphatase and tensin homolog deleted on chromosome 10 decreases rat cortical neuron injury and blood-brain barrier permeability, and improves neurological functional recovery in traumatic brain injury model
-
doi: 10.1371/journal.pone.0080429
-
Ding, J., Guo, J., Yuan, Q., Yuan, F., Chen, H., and Tian, H. (2013). Inhibition of phosphatase and tensin homolog deleted on chromosome 10 decreases rat cortical neuron injury and blood-brain barrier permeability, and improves neurological functional recovery in traumatic brain injury model. PloS ONE 8:e80429. doi: 10.1371/journal.pone.0080429
-
(2013)
PloS ONE
, vol.8
-
-
Ding, J.1
Guo, J.2
Yuan, Q.3
Yuan, F.4
Chen, H.5
Tian, H.6
-
23
-
-
33749836234
-
Phosphoinositides in cell regulation and membrane dynamics
-
doi: 10.1038/nature05185
-
Di Paolo, G., and De Camilli, P. (2006). Phosphoinositides in cell regulation and membrane dynamics. Nature 443, 651-657. doi: 10.1038/nature05185
-
(2006)
Nature
, vol.443
, pp. 651-657
-
-
Di Paolo, G.1
De Camilli, P.2
-
24
-
-
80052668585
-
Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models
-
doi: 10.1096/fj.11-181958
-
Domanskyi, A., Geissler, C., Vinnikov, I. A., Alter, H., Schober, A., Vogt, M. A., et al. (2011). Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models. FASEB J. 25, 2898-2910. doi: 10.1096/fj.11-181958
-
(2011)
FASEB J.
, vol.25
, pp. 2898-2910
-
-
Domanskyi, A.1
Geissler, C.2
Vinnikov, I.A.3
Alter, H.4
Schober, A.5
Vogt, M.A.6
-
25
-
-
0030902595
-
Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid-and human amylin-induced toxicity
-
Doré, S., Kar, S., and Quirion, R. (1997). Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid-and human amylin-induced toxicity. Proc. Natl. Acad. Sci. U.S.A. 94, 4772-4777.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 4772-4777
-
-
Doré, S.1
Kar, S.2
Quirion, R.3
-
26
-
-
75949103435
-
E3 ligase Nedd4 promotes axon branching by downregulating PTEN
-
doi: 10.1016/j.neuron.2010.01.017
-
Drinjakovic, J., Jung, H., Campbell, D. S., Strochlic, L., Dwivedy, A., and Holt, C. E. (2010). E3 ligase Nedd4 promotes axon branching by downregulating PTEN. Neuron 65, 341-357. doi: 10.1016/j.neuron.2010.01.017
-
(2010)
Neuron
, vol.65
, pp. 341-357
-
-
Drinjakovic, J.1
Jung, H.2
Campbell, D.S.3
Strochlic, L.4
Dwivedy, A.5
Holt, C.E.6
-
27
-
-
41149165141
-
Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase
-
doi: 10.1371/journal.pone.0000869
-
Eickholt, B. J., Ahmed, A. I., Davies, M., Papakonstanti, E. A., Pearce, W., Starkey, M. L., et al. (2007). Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase. PLoS ONE 2:e869. doi: 10.1371/journal.pone.0000869
-
(2007)
PLoS ONE
, vol.2
-
-
Eickholt, B.J.1
Ahmed, A.I.2
Davies, M.3
Papakonstanti, E.A.4
Pearce, W.5
Starkey, M.L.6
-
28
-
-
0042316755
-
PTEN: One gene, many syndromes
-
doi: 10.1002/humu.10257
-
Eng, C. (2003). PTEN: one gene, many syndromes. Hum. Mutat. 22, 183-198. doi: 10.1002/humu.10257
-
(2003)
Hum. Mutat.
, vol.22
, pp. 183-198
-
-
Eng, C.1
-
29
-
-
84865542459
-
Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240
-
doi: 10.1073/pnas.1211962109
-
Fenton, T. R., Nathanson, D., Ponte de Albuquerque, C., Kuga, D., Iwanami, A., Dang, J., et al. (2012). Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proc. Natl. Acad. Sci. U.S.A. 109, 14164-14169. doi: 10.1073/pnas.1211962109
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 14164-14169
-
-
Fenton, T.R.1
Nathanson, D.2
Ponte de Albuquerque, C.3
Kuga, D.4
Iwanami, A.5
Dang, J.6
-
30
-
-
69949170092
-
Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a
-
doi: 10.1126/science.1173569
-
Fine, B., Hodakoski, C., Koujak, S., Su, T., Saal, L. H., Maurer, M., et al. (2009). Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science 325, 1261-1265. doi: 10.1126/science.1173569
-
(2009)
Science
, vol.325
, pp. 1261-1265
-
-
Fine, B.1
Hodakoski, C.2
Koujak, S.3
Su, T.4
Saal, L.H.5
Maurer, M.6
-
31
-
-
37849027524
-
Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities
-
doi: 10.1016/j.neuroscience.2007.10.048
-
Fraser, M. M., Bayazitov, I. T., Zakharenko, S. S., and Baker, S. J. (2008). Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. Neuroscience 151, 476-488. doi: 10.1016/j.neuroscience.2007.10.048
-
(2008)
Neuroscience
, vol.151
, pp. 476-488
-
-
Fraser, M.M.1
Bayazitov, I.T.2
Zakharenko, S.S.3
Baker, S.J.4
-
32
-
-
7444264727
-
Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo
-
doi: 10.1158/0008-5472.CAN-04-2487
-
Fraser, M. M., Zhu, X., Kwon, C.-H., Uhlmann, E. J., Gutmann, D. H., and Baker, S. J. (2004). Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo. Cancer Res. 64, 7773-7779. doi: 10.1158/0008-5472.CAN-04-2487
-
(2004)
Cancer Res.
, vol.64
, pp. 7773-7779
-
-
Fraser, M.M.1
Zhu, X.2
Kwon, C.-H.3
Uhlmann, E.J.4
Gutmann, D.H.5
Baker, S.J.6
-
33
-
-
0041450058
-
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and-independent mechanisms
-
doi: 10.1016/S1535-6108(03)00021-7
-
Freeman, D. J., Li, A. G., Wei, G., Li, H.-H., Kertesz, N., Lesche, R., et al. (2003). PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and-independent mechanisms. Cancer Cell 3, 117-130. doi: 10.1016/S1535-6108(03)00021-7
-
(2003)
Cancer Cell
, vol.3
, pp. 117-130
-
-
Freeman, D.J.1
Li, A.G.2
Wei, G.3
Li, H.-H.4
Kertesz, N.5
Lesche, R.6
-
34
-
-
84878288766
-
RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms
-
doi: 10.1016/j.cell.2013.04.031
-
Fritsch, R., de Krijger, I., Fritsch, K., George, R., Reason, B., Kumar, M. S., et al. (2013). RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms. Cell 153, 1050-1063. doi: 10.1016/j.cell.2013.04.031
-
(2013)
Cell
, vol.153
, pp. 1050-1063
-
-
Fritsch, R.1
de Krijger, I.2
Fritsch, K.3
George, R.4
Reason, B.5
Kumar, M.S.6
-
35
-
-
84886810676
-
Extracellular vesicles as mediators of neuron-glia communication
-
doi: 10.3389/fncel.2013.00182
-
Frühbeis, C., Fröhlich, D., Kuo, W. P., and Krämer-Albers, E.-M. (2013). Extracellular vesicles as mediators of neuron-glia communication. Front. Cell. Neurosci. 7:182. doi: 10.3389/fncel.2013.00182
-
(2013)
Front. Cell. Neurosci.
, vol.7
, pp. 182
-
-
Frühbeis, C.1
Fröhlich, D.2
Kuo, W.P.3
Krämer-Albers, E.-M.4
-
36
-
-
80855132485
-
New insights into the role of mitochondria-associated endoplasmic reticulum membrane
-
doi: 10.1016/B978-0-12-386033-0.00002-5
-
Fujimoto, M., and Hayashi, T. (2011). New insights into the role of mitochondria-associated endoplasmic reticulum membrane. Int. Rev. Cell Mol. Biol. 292, 73-117. doi: 10.1016/B978-0-12-386033-0.00002-5
-
(2011)
Int. Rev. Cell Mol. Biol.
, vol.292
, pp. 73-117
-
-
Fujimoto, M.1
Hayashi, T.2
-
37
-
-
84880823162
-
Regulation of the tumor suppressor PTEN through exosomes: A diagnostic potential for prostate cancer
-
doi: 10.1371/journal.pone.0070047
-
Gabriel, K., Ingram, A., Austin, R., Kapoor, A., Tang, D., Majeed, F., et al. (2013). Regulation of the tumor suppressor PTEN through exosomes: a diagnostic potential for prostate cancer. PloS ONE 8:e70047. doi: 10.1371/journal.pone.0070047
-
(2013)
PloS ONE
, vol.8
-
-
Gabriel, K.1
Ingram, A.2
Austin, R.3
Kapoor, A.4
Tang, D.5
Majeed, F.6
-
38
-
-
84885434025
-
More than one ring to bind them all: Recent insights into the structure of the axon
-
doi: 10.1002/dneu.22100
-
Gallo, G. (2013). More than one ring to bind them all: recent insights into the structure of the axon. Dev. Neurobiol. 73, 799-805. doi: 10.1002/dneu.22100
-
(2013)
Dev. Neurobiol.
, vol.73
, pp. 799-805
-
-
Gallo, G.1
-
39
-
-
80052275615
-
PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains
-
doi: 10.1073/pnas.1019386108
-
Gao, X., Lowry, P. R., Zhou, X., Depry, C., Wei, Z., Wong, G. W., et al. (2011). PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains. Proc. Natl. Acad. Sci. U.S.A. 108, 14509-14514. doi: 10.1073/pnas.1019386108
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 14509-14514
-
-
Gao, X.1
Lowry, P.R.2
Zhou, X.3
Depry, C.4
Wei, Z.5
Wong, G.W.6
-
40
-
-
33748319341
-
Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs
-
doi: 10.1091/mbc.E06-05-0380
-
Gil, A., Andrés-Pons, A., Fernéndez, E., Valiente, M., Torres, J., Cervera, J., et al. (2006). Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs. Mol. Biol. Cell 17, 4002-4013. doi: 10.1091/mbc.E06-05-0380
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 4002-4013
-
-
Gil, A.1
Andrés-Pons, A.2
Fernéndez, E.3
Valiente, M.4
Torres, J.5
Cervera, J.6
-
41
-
-
0033843623
-
Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors
-
doi: 10.1016/S0002-9440(10)65040-7
-
Gimm, O., Perren, A., Weng, L. P., Marsh, D. J., Yeh, J. J., Ziebold, U., et al. (2000). Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors. Am. J. Pathol. 156, 1693-1700. doi: 10.1016/S0002-9440(10)65040-7
-
(2000)
Am. J. Pathol.
, vol.156
, pp. 1693-1700
-
-
Gimm, O.1
Perren, A.2
Weng, L.P.3
Marsh, D.J.4
Yeh, J.J.5
Ziebold, U.6
-
42
-
-
84890081732
-
Nuclear trafficking of Pten after brain injury leads to neuron survival not death
-
doi: 10.1016/j.expneurol.2013.11.017
-
Goh, C.-P., Putz, U., Howitt, J., Low, L.-H., Gunnersen, J., Bye, N., et al. (2013). Nuclear trafficking of Pten after brain injury leads to neuron survival not death. Exp. Neurol. 252C, 37-46. doi: 10.1016/j.expneurol.2013.11.017
-
(2013)
Exp. Neurol.
, vol.252 C
, pp. 37-46
-
-
Goh, C.-P.1
Putz, U.2
Howitt, J.3
Low, L.-H.4
Gunnersen, J.5
Bye, N.6
-
43
-
-
84867195016
-
Regulation of the tumor suppressor PTEN by SUMO
-
doi: 10.1038/cddis.2012.135
-
González-Santamaría, J., Campagna, M., Ortega-Molina, A., Marcos-Villar, L., de la Cruz-Herrera, C. F., González, D., et al. (2012). Regulation of the tumor suppressor PTEN by SUMO. Cell Death Dis. 3, e393. doi: 10.1038/cddis.2012.135
-
(2012)
Cell Death Dis.
, vol.3
-
-
González-Santamaría, J.1
Campagna, M.2
Ortega-Molina, A.3
Marcos-Villar, L.4
de la Cruz-Herrera, C.F.5
González, D.6
-
44
-
-
24744459879
-
Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines
-
doi: 10.1002/jnr.20550
-
Goswami, R., Singh, D., Phillips, G., Kilkus, J., and Dawson, G. (2005). Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines. J. Neurosci. Res. 81, 541-550. doi: 10.1002/jnr.20550
-
(2005)
J. Neurosci. Res.
, vol.81
, pp. 541-550
-
-
Goswami, R.1
Singh, D.2
Phillips, G.3
Kilkus, J.4
Dawson, G.5
-
45
-
-
16244391770
-
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
-
doi: 10.1111/j.1471-4159.2004.02949.x
-
Griffin, R. J., Moloney, A., Kelliher, M., Johnston, J. A., Ravid, R., Dockery, P., et al. (2005). Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J. Neurochem. 93, 105-117. doi: 10.1111/j.1471-4159.2004.02949.x
-
(2005)
J. Neurochem.
, vol.93
, pp. 105-117
-
-
Griffin, R.J.1
Moloney, A.2
Kelliher, M.3
Johnston, J.A.4
Ravid, R.5
Dockery, P.6
-
46
-
-
0035824396
-
Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo
-
doi: 10.1126/science.1065518
-
Groszer, M., Erickson, R., Scripture-Adams, D. D., Lesche, R., Trumpp, A., Zack, J. A., et al. (2001). Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 294, 2186-2189. doi: 10.1126/science.1065518
-
(2001)
Science
, vol.294
, pp. 2186-2189
-
-
Groszer, M.1
Erickson, R.2
Scripture-Adams, D.D.3
Lesche, R.4
Trumpp, A.5
Zack, J.A.6
-
47
-
-
0026487365
-
Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase
-
doi: 10.1016/0304-3940(92)90774-2
-
Hanger, D. P., Hughes, K., Woodgett, J. R., Brion, J. P., and Anderton, B. H. (1992). Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase. Neurosci. Lett. 147, 58-62. doi: 10.1016/0304-3940(92)90774-2
-
(1992)
Neurosci. Lett.
, vol.147
, pp. 58-62
-
-
Hanger, D.P.1
Hughes, K.2
Woodgett, J.R.3
Brion, J.P.4
Anderton, B.H.5
-
48
-
-
33751297031
-
Signalling through Class I PI3Ks in mammalian cells
-
doi: 10.1042/BST0340647
-
Hawkins, P. T., Anderson, K. E., Davidson, K., and Stephens, L. R. (2006). Signalling through Class I PI3Ks in mammalian cells. Biochem. Soc. Trans. 34, 647-662. doi: 10.1042/BST0340647
-
(2006)
Biochem. Soc. Trans.
, vol.34
, pp. 647-662
-
-
Hawkins, P.T.1
Anderson, K.E.2
Davidson, K.3
Stephens, L.R.4
-
49
-
-
84893732333
-
PTEN knockdown alters dendritic spine/protrusion morphology, not density
-
doi: 10.1002/cne.23488
-
Haws, M. E., Jaramillo, T. C., Espinosa-Becerra, F., Widman, A., Stuber, G. D., Sparta, D. R., et al. (2014). PTEN knockdown alters dendritic spine/protrusion morphology, not density. J. Comp. Neurol. 522, 1171-1190. doi: 10.1002/cne.23488
-
(2014)
J. Comp. Neurol.
, vol.522
, pp. 1171-1190
-
-
Haws, M.E.1
Jaramillo, T.C.2
Espinosa-Becerra, F.3
Widman, A.4
Stuber, G.D.5
Sparta, D.R.6
-
50
-
-
0029825623
-
Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex
-
Hayashi, K., Ishikawa, R., Ye, L. H., He, X. L., Takata, K., Kohama, K., et al. (1996). Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex. J. Neurosci. 16, 7161-7170.
-
(1996)
J. Neurosci.
, vol.16
, pp. 7161-7170
-
-
Hayashi, K.1
Ishikawa, R.2
Ye, L.H.3
He, X.L.4
Takata, K.5
Kohama, K.6
-
51
-
-
84877337663
-
Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models
-
doi: 10.1073/pnas.1300677110
-
Hedskog, L., Pinho, C. M., Filadi, R., Ronnback, A., Hertwig, L., Wiehager, B., et al. (2013). Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models. Proc. Natl. Acad. Sci. U.S.A. 110, 7916-7921. doi: 10.1073/pnas.1300677110
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 7916-7921
-
-
Hedskog, L.1
Pinho, C.M.2
Filadi, R.3
Ronnback, A.4
Hertwig, L.5
Wiehager, B.6
-
52
-
-
84880554229
-
Differential role of PTEN phosphatase in chemotactic growth cone guidance
-
doi: 10.1074/jbc.C113.487066
-
Henle, S. J., Carlstrom, L. P., Cheever, T. R., and Henley, J. R. (2013). Differential role of PTEN phosphatase in chemotactic growth cone guidance. J. Biol. Chem. 288, 20837-20842. doi: 10.1074/jbc.C113.487066
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 20837-20842
-
-
Henle, S.J.1
Carlstrom, L.P.2
Cheever, T.R.3
Henley, J.R.4
-
53
-
-
79956300659
-
Asymmetric PI(3,4,5)P3 and Akt signaling mediates chemotaxis of axonal growth cones
-
doi: 10.1523/JNEUROSCI.0216-11.2011
-
Henle, S. J., Wang, G., Liang, E., Wu, M., Poo, M.-M., and Henley, J. R. (2011). Asymmetric PI(3,4,5)P3 and Akt signaling mediates chemotaxis of axonal growth cones. J. Neurosci. 31, 7016-7027. doi: 10.1523/JNEUROSCI.0216-11.2011
-
(2011)
J. Neurosci.
, vol.31
, pp. 7016-7027
-
-
Henle, S.J.1
Wang, G.2
Liang, E.3
Wu, M.4
Poo, M.-M.5
Henley, J.R.6
-
54
-
-
84892832761
-
Biochemical screening and PTEN mutation analysis in individuals with autism spectrum disorders and macrocephaly
-
doi: 10.1038/ejhg.2013.114
-
Hobert, J. A., Embacher, R., Mester, J. L., Frazier, T. W. 2nd., and Eng, C. (2014). Biochemical screening and PTEN mutation analysis in individuals with autism spectrum disorders and macrocephaly. Eur. J. Hum. Genet. 22, 273-276. doi: 10.1038/ejhg.2013.114
-
(2014)
Eur. J. Hum. Genet.
, vol.22
, pp. 273-276
-
-
Hobert, J.A.1
Embacher, R.2
Mester, J.L.3
Frazier II, T.W.4
Eng, C.5
-
55
-
-
84891945711
-
Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis
-
doi: 10.1073/pnas.1213773111
-
Hodakoski, C., Hopkins, B. D., Barrows, D., Mense, S. M., Keniry, M., Anderson, K. E., et al. (2014). Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis. Proc. Natl. Acad. Sci. U.S.A. 111, 155-160. doi: 10.1073/pnas.1213773111
-
(2014)
Proc. Natl. Acad. Sci. U.S.A.
, vol.111
, pp. 155-160
-
-
Hodakoski, C.1
Hopkins, B.D.2
Barrows, D.3
Mense, S.M.4
Keniry, M.5
Anderson, K.E.6
-
56
-
-
84880737776
-
A secreted PTEN phosphatase that enters cells to alter signaling and survival
-
doi: 10.1126/science.1234907
-
Hopkins, B. D., Fine, B., Steinbach, N., Dendy, M., Rapp, Z., Shaw, J., et al. (2013). A secreted PTEN phosphatase that enters cells to alter signaling and survival. Science 341, 399-402. doi: 10.1126/science.1234907
-
(2013)
Science
, vol.341
, pp. 399-402
-
-
Hopkins, B.D.1
Fine, B.2
Steinbach, N.3
Dendy, M.4
Rapp, Z.5
Shaw, J.6
-
57
-
-
84863012466
-
Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia
-
doi: 10.1083/jcb.201105009
-
Howitt, J., Lackovic, J., Low, L.-H., Naguib, A., Macintyre, A., Goh, C.-P., et al. (2012). Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. J. Cell Biol. 196, 29-36. doi: 10.1083/jcb.201105009
-
(2012)
J. Cell Biol.
, vol.196
, pp. 29-36
-
-
Howitt, J.1
Lackovic, J.2
Low, L.-H.3
Naguib, A.4
McIntyre, A.5
Goh, C.-P.6
-
58
-
-
84863336040
-
SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane
-
doi: 10.1038/ncomms1919
-
Huang, J., Yan, J., Zhang, J., Zhu, S., Wang, Y., Shi, T., et al. (2012). SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nat. Commun. 3, 911. doi: 10.1038/ncomms1919.
-
(2012)
Nat. Commun.
, vol.3
, pp. 911
-
-
Huang, J.1
Yan, J.2
Zhang, J.3
Zhu, S.4
Wang, Y.5
Shi, T.6
-
59
-
-
77954874401
-
GSK3 signalling in neural development
-
doi: 10.1038/nrn2870
-
Hur, E.-M., and Zhou, F.-Q. (2010). GSK3 signalling in neural development. Nat. Rev. Neurosci. 11, 539-551. doi: 10.1038/nrn2870
-
(2010)
Nat. Rev. Neurosci.
, vol.11
, pp. 539-551
-
-
Hur, E.-M.1
Zhou, F.-Q.2
-
60
-
-
84887305258
-
Coordinate regulation of mature dopaminergic axon morphology by macroautophagy and the PTEN signaling pathway
-
doi: 10.1371/journal.pgen.1003845
-
Inoue, K., Rispoli, J., Yang, L., Macleod, D., Beal, M. F., Klann, E., et al. (2013). Coordinate regulation of mature dopaminergic axon morphology by macroautophagy and the PTEN signaling pathway. PLoS Genet. 9:e1003845. doi: 10.1371/journal.pgen.1003845
-
(2013)
PLoS Genet.
, vol.9
-
-
Inoue, K.1
Rispoli, J.2
Yang, L.3
McLeod, D.4
Beal, M.F.5
Klann, E.6
-
61
-
-
77955850746
-
PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression
-
doi: 10.1038/emboj.2010.160
-
Jurado, S., Benoist, M., Lario, A., Knafo, S., Petrok, C. N., and Esteban, J. A. (2010). PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression. EMBO J. 29, 2827-2840. doi: 10.1038/emboj.2010.160
-
(2010)
EMBO J.
, vol.29
, pp. 2827-2840
-
-
Jurado, S.1
Benoist, M.2
Lario, A.3
Knafo, S.4
Petrok, C.N.5
Esteban, J.A.6
-
62
-
-
84881335837
-
Optogenetic control of PIP3: PIP3 is sufficient to induce the actin-based active part of growth cones and is regulated via endocytosis
-
doi: 10.1371/journal.pone.0070861
-
Kakumoto, T., and Nakata, T. (2013). Optogenetic control of PIP3: PIP3 is sufficient to induce the actin-based active part of growth cones and is regulated via endocytosis. PloS ONE 8:e70861. doi: 10.1371/journal.pone.0070861
-
(2013)
PloS ONE
, vol.8
-
-
Kakumoto, T.1
Nakata, T.2
-
63
-
-
84876817056
-
Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration
-
doi: 10.1073/pnas.1220755110
-
Karunarathne, W. K. A., Giri, L., Patel, A. K., Venkatesh, K. V., and Gautam, N. (2013). Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration. Proc. Natl. Acad. Sci. U.S.A. 110, E1575-1583. doi: 10.1073/pnas.1220755110
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
-
-
Karunarathne, W.K.A.1
Giri, L.2
Patel, A.K.3
Venkatesh, K.V.4
Gautam, N.5
-
64
-
-
84872001794
-
PNUTS functions as a proto-oncogene by sequestering PTEN
-
doi: 10.1158/0008-5472.CAN-12-1394
-
Kavela, S., Shinde, S. R., Ratheesh, R., Viswakalyan, K., Bashyam, M. D., Gowrishankar, S., et al. (2013). PNUTS functions as a proto-oncogene by sequestering PTEN. Cancer Res. 73, 205-214. doi: 10.1158/0008-5472.CAN-12-1394
-
(2013)
Cancer Res.
, vol.73
, pp. 205-214
-
-
Kavela, S.1
Shinde, S.R.2
Ratheesh, R.3
Viswakalyan, K.4
Bashyam, M.D.5
Gowrishankar, S.6
-
65
-
-
33646751445
-
PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3
-
doi: 10.1016/j.febslet.2006.04.064
-
Kerr, F., Rickle, A., Nayeem, N., Brandner, S., Cowburn, R. F., and Lovestone, S. (2006). PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3. FEBS Lett. 580, 3121-3128. doi: 10.1016/j.febslet.2006.04.064
-
(2006)
FEBS Lett.
, vol.580
, pp. 3121-3128
-
-
Kerr, F.1
Rickle, A.2
Nayeem, N.3
Brandner, S.4
Cowburn, R.F.5
Lovestone, S.6
-
66
-
-
77956568206
-
Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia
-
doi: 10.1523/JNEUROSCI.1740-10.2010
-
Ketschek, A., and Gallo, G. (2010). Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia. J. Neurosci. 30, 12185-12197. doi: 10.1523/JNEUROSCI.1740-10.2010
-
(2010)
J. Neurosci.
, vol.30
, pp. 12185-12197
-
-
Ketschek, A.1
Gallo, G.2
-
67
-
-
80054977111
-
PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility
-
doi: 10.1038/nn.2937
-
Kim, J.-I., Lee, H.-R., Sim, S., Baek, J., Yu, N.-K., Choi, J.-H., et al. (2011a). PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility. Nat. Neurosci. 14, 1447-1454. doi: 10.1038/nn.2937
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 1447-1454
-
-
Kim, J.-I.1
Lee, H.-R.2
Sim, S.3
Baek, J.4
Yu, N.-K.5
Choi, J.-H.6
-
68
-
-
79959403545
-
Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells
-
doi: 10.1128/MCB.01323-10
-
Kim, J.-S., Xu, X., Li, H., Solomon, D., Lane, W. S., Jin, T., et al. (2011b). Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells. Mol. Cell. Biol. 31, 2756-2771. doi: 10.1128/MCB.01323-10
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 2756-2771
-
-
Kim, J.-S.1
Xu, X.2
Li, H.3
Solomon, D.4
Lane, W.S.5
Jin, T.6
-
69
-
-
79551690481
-
Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis
-
doi: 10.1093/brain/awq345
-
Kirby, J., Ning, K., Ferraiuolo, L., Heath, P. R., Ismail, A., Kuo, S.-W., et al. (2011). Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis. Brain 134, 506-517. doi: 10.1093/brain/awq345
-
(2011)
Brain
, vol.134
, pp. 506-517
-
-
Kirby, J.1
Ning, K.2
Ferraiuolo, L.3
Heath, P.R.4
Ismail, A.5
Kuo, S.-W.6
-
70
-
-
84874097245
-
Macrocephaly as a clinical indicator of genetic subtypes in autism
-
doi: 10.1002/aur.1266
-
Klein, S., Sharifi-Hannauer, P., and Martinez-Agosto, J. A. (2013). Macrocephaly as a clinical indicator of genetic subtypes in autism. Autism Res. 6, 51-56. doi: 10.1002/aur.1266
-
(2013)
Autism Res.
, vol.6
, pp. 51-56
-
-
Klein, S.1
Sharifi-Hannauer, P.2
Martinez-Agosto, J.A.3
-
71
-
-
5044244482
-
Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics
-
doi: 10.1016/j.devcel.2004.07.024
-
Krause, M., Leslie, J. D., Stewart, M., Lafuente, E. M., Valderrama, F., Jagannathan, R., et al. (2004). Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Dev. Cell 7, 571-583. doi: 10.1016/j.devcel.2004.07.024
-
(2004)
Dev. Cell
, vol.7
, pp. 571-583
-
-
Krause, M.1
Leslie, J.D.2
Stewart, M.3
Lafuente, E.M.4
Valderrama, F.5
Jagannathan, R.6
-
72
-
-
84881099545
-
Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN
-
doi: 10.1371/journal.pone.0071957
-
Kreis, P., Hendricusdottir, R., Kay, L., Papageorgiou, I. E., van Diepen, M., Mack, T., et al. (2013). Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN. PLoS ONE 8:e71957. doi: 10.1371/journal.pone.0071957
-
(2013)
PLoS ONE
, vol.8
-
-
Kreis, P.1
Hendricusdottir, R.2
Kay, L.3
Papageorgiou, I.E.4
van Diepen, M.5
Mack, T.6
-
73
-
-
77955293704
-
Regulation of PTEN in neurons by myosin-based transport mechanisms
-
doi: 10.1016/j.advenzreg.2009.10.014
-
Kreis, P., van Diepen, M. T., and Eickholt, B. J. (2010). Regulation of PTEN in neurons by myosin-based transport mechanisms. Adv. Enzyme Regul. 50, 119-124. doi: 10.1016/j.advenzreg.2009.10.014
-
(2010)
Adv. Enzyme Regul.
, vol.50
, pp. 119-124
-
-
Kreis, P.1
van Diepen, M.T.2
Eickholt, B.J.3
-
74
-
-
18244392475
-
Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices
-
doi: 10.1016/S1097-2765(02)00434-3
-
Krugmann, S., Anderson, K. E., Ridley, S. H., Risso, N., McGregor, A., Coadwell, J., et al. (2002). Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Mol. Cell 9, 95-108. doi: 10.1016/S1097-2765(02)00434-3
-
(2002)
Mol. Cell
, vol.9
, pp. 95-108
-
-
Krugmann, S.1
Anderson, K.E.2
Ridley, S.H.3
Risso, N.4
McGregor, A.5
Coadwell, J.6
-
75
-
-
78149253527
-
NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration
-
doi: 10.1186/1750-1326-5-49
-
Kwak, Y.-D., Ma, T., Diao, S., Zhang, X., Chen, Y., Hsu, J., et al. (2010). NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration. Mol. Neurodegener. 5, 49. doi: 10.1186/1750-1326-5-49
-
(2010)
Mol. Neurodegener.
, vol.5
, pp. 49
-
-
Kwak, Y.-D.1
Ma, T.2
Diao, S.3
Zhang, X.4
Chen, Y.5
Hsu, J.6
-
76
-
-
33646142995
-
Pten regulates neuronal arborization and social interaction in mice
-
doi: 10.1016/j.neuron.2006.03.023
-
Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., et al. (2006). Pten regulates neuronal arborization and social interaction in mice. Neuron 50, 377-388. doi: 10.1016/j.neuron.2006.03.023
-
(2006)
Neuron
, vol.50
, pp. 377-388
-
-
Kwon, C.-H.1
Luikart, B.W.2
Powell, C.M.3
Zhou, J.4
Matheny, S.A.5
Zhang, W.6
-
77
-
-
0035734381
-
Pten regulates neuronal soma size: A mouse model of Lhermitte-Duclos disease
-
doi: 10.1038/ng781
-
Kwon, C. H., Zhu, X., Zhang, J., Knoop, L. L., Tharp, R., Smeyne, R. J., et al. (2001). Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat. Genet. 29, 404-411. doi: 10.1038/ng781
-
(2001)
Nat. Genet.
, vol.29
, pp. 404-411
-
-
Kwon, C.H.1
Zhu, X.2
Zhang, J.3
Knoop, L.L.4
Tharp, R.5
Smeyne, R.J.6
-
78
-
-
34548817013
-
Cowden syndrome and Bannayan Riley Ruvalcaba syndrome represent one condition with variable expression and age-related penetrance: Results of a clinical study of PTEN mutation carriers
-
doi: 10.1136/jmg.2007.049981
-
Lachlan, K. L., Lucassen, A. M., Bunyan, D., and Temple, I. K. (2007). Cowden syndrome and Bannayan Riley Ruvalcaba syndrome represent one condition with variable expression and age-related penetrance: results of a clinical study of PTEN mutation carriers. J. Med. Genet. 44, 579-585. doi: 10.1136/jmg.2007.049981
-
(2007)
J. Med. Genet.
, vol.44
, pp. 579-585
-
-
Lachlan, K.L.1
Lucassen, A.M.2
Bunyan, D.3
Temple, I.K.4
-
79
-
-
0034652102
-
A role for nuclear PTEN in neuronal differentiation
-
Lachyankar, M. B., Sultana, N., Schonhoff, C. M., Mitra, P., Poluha, W., Lambert, S., et al. (2000). A role for nuclear PTEN in neuronal differentiation. J. Neurosci. 20, 1404-1413.
-
(2000)
J. Neurosci.
, vol.20
, pp. 1404-1413
-
-
Lachyankar, M.B.1
Sultana, N.2
Schonhoff, C.M.3
Mitra, P.4
Poluha, W.5
Lambert, S.6
-
80
-
-
0033615538
-
Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
-
doi: 10.1016/S0092-8674(00)81663-3
-
Lee, J. O., Yang, H., Georgescu, M. M., Di Cristofano, A., Maehama, T., Shi, Y., et al. (1999). Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 99, 323-334. doi: 10.1016/S0092-8674(00)81663-3
-
(1999)
Cell
, vol.99
, pp. 323-334
-
-
Lee, J.O.1
Yang, H.2
Georgescu, M.M.3
Di Cristofano, A.4
Maehama, T.5
Shi, Y.6
-
81
-
-
51849167782
-
Understanding PTEN regulation: PIP2, polarity and protein stability
-
doi: 10.1038/onc.2008.243
-
Leslie, N. R., Batty, I. H., Maccario, H., Davidson, L., and Downes, C. P. (2008). Understanding PTEN regulation: PIP2, polarity and protein stability. Oncogene 27, 5464-5476. doi: 10.1038/onc.2008.243
-
(2008)
Oncogene
, vol.27
, pp. 5464-5476
-
-
Leslie, N.R.1
Batty, I.H.2
McCario, H.3
Davidson, L.4
Downes, C.P.5
-
82
-
-
20244379418
-
Regulation of PTEN by Rho small GTPases
-
doi: 10.1038/ncb1236
-
Li, Z., Dong, X., Dong, X., Wang, Z., Liu, W., Deng, N., et al. (2005). Regulation of PTEN by Rho small GTPases. Nat. Cell Biol. 7, 399-404. doi: 10.1038/ncb1236
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 399-404
-
-
Li, Z.1
Dong, X.2
Dong, X.3
Wang, Z.4
Liu, W.5
Deng, N.6
-
83
-
-
27844535741
-
Class reunion: PTEN joins the nuclear crew
-
doi: 10.1038/sj.onc.1209089
-
Lian, Z., and Di Cristofano, A. (2005). Class reunion: PTEN joins the nuclear crew. Oncogene 24, 7394-7400. doi: 10.1038/sj.onc.1209089
-
(2005)
Oncogene
, vol.24
, pp. 7394-7400
-
-
Lian, Z.1
Di Cristofano, A.2
-
84
-
-
79960038559
-
Distinct functional outputs of PTEN signalling are controlled by dynamic association with beta-arrestins
-
doi: 10.1038/emboj.2011.178
-
Lima-Fernandes, E., Enslen, H., Camand, E., Kotelevets, L., Boularan, C., Achour, L., et al. (2011). Distinct functional outputs of PTEN signalling are controlled by dynamic association with beta-arrestins. EMBO J. 30, 2557-2568. doi: 10.1038/emboj.2011.178
-
(2011)
EMBO J.
, vol.30
, pp. 2557-2568
-
-
Lima-Fernandes, E.1
Enslen, H.2
Camand, E.3
Kotelevets, L.4
Boularan, C.5
Achour, L.6
-
85
-
-
84860389181
-
A mosaic activating mutation in AKT1 associated with the Proteus syndrome
-
doi: 10.1056/NEJMoa1104017
-
Lindhurst, M. J., Sapp, J. C., Teer, J. K., Johnston, J. J., Finn, E. M., Peters, K., et al. (2011). A mosaic activating mutation in AKT1 associated with the Proteus syndrome. N. Engl. J. Med. 365, 611-619. doi: 10.1056/NEJMoa1104017
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 611-619
-
-
Lindhurst, M.J.1
Sapp, J.C.2
Teer, J.K.3
Johnston, J.J.4
Finn, E.M.5
Peters, K.6
-
86
-
-
33845972919
-
Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression
-
doi: 10.1242/jcs.000133
-
Lindsay, Y., McCoull, D., Davidson, L., Leslie, N. R., Fairservice, A., Gray, A., et al. (2006). Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression. J. Cell Sci. 119, 5160-5168. doi: 10.1242/jcs.000133
-
(2006)
J. Cell Sci.
, vol.119
, pp. 5160-5168
-
-
Lindsay, Y.1
McCoull, D.2
Davidson, L.3
Leslie, N.R.4
Fairservice, A.5
Gray, A.6
-
87
-
-
77956187905
-
PTEN deletion enhances the regenerative ability of adult corticospinal neurons
-
doi: 10.1038/nn.2603
-
Liu, K., Lu, Y., Lee, J. K., Samara, R., Willenberg, R., Sears-Kraxberger, I., et al. (2010). PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat. Neurosci. 13, 1075-1081. doi: 10.1038/nn.2603
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 1075-1081
-
-
Liu, K.1
Lu, Y.2
Lee, J.K.3
Samara, R.4
Willenberg, R.5
Sears-Kraxberger, I.6
-
88
-
-
79952770185
-
Pten knockdown in vivo increases excitatory drive onto dentate granule cells
-
doi: 10.1523/JNEUROSCI.0061-11.2011
-
Luikart, B. W., Schnell, E., Washburn, E. K., Bensen, A. L., Tovar, K. R., and Westbrook, G. L. (2011). Pten knockdown in vivo increases excitatory drive onto dentate granule cells. J. Neurosci. 31, 4345-4354. doi: 10.1523/JNEUROSCI.0061-11.2011
-
(2011)
J. Neurosci.
, vol.31
, pp. 4345-4354
-
-
Luikart, B.W.1
Schnell, E.2
Washburn, E.K.3
Bensen, A.L.4
Tovar, K.R.5
Westbrook, G.L.6
-
89
-
-
84873381777
-
Defining the membrane-associated state of the PTEN tumor suppressor protein
-
doi: 10.1016/j.bpj.2012.12.002
-
Lumb, C. N., and Sansom, M. S. P. (2013). Defining the membrane-associated state of the PTEN tumor suppressor protein. Biophys. J. 104, 613-621. doi: 10.1016/j.bpj.2012.12.002
-
(2013)
Biophys. J.
, vol.104
, pp. 613-621
-
-
Lumb, C.N.1
Sansom, M.S.P.2
-
90
-
-
84872395057
-
Neuron-intrinsic inhibitors of axon regeneration: PTEN and SOCS3
-
doi: 10.1016/B978-0-12-398309-1.00008-1
-
Luo, X., and Park, K. K. (2012). Neuron-intrinsic inhibitors of axon regeneration: PTEN and SOCS3. Int. Rev. Neurobiol. 105, 141-173. doi: 10.1016/B978-0-12-398309-1.00008-1
-
(2012)
Int. Rev. Neurobiol.
, vol.105
, pp. 141-173
-
-
Luo, X.1
Park, K.K.2
-
91
-
-
77951234781
-
Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress
-
doi: 10.1074/jbc.M109.072280
-
Maccario, H., Perera, N. M., Gray, A., Downes, C. P., and Leslie, N. R. (2010). Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress. J. Biol. Chem. 285, 12620-12628. doi: 10.1074/jbc.M109.072280
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 12620-12628
-
-
McCario, H.1
Perera, N.M.2
Gray, A.3
Downes, C.P.4
Leslie, N.R.5
-
92
-
-
84879619834
-
Intrinsic disorder in PTEN and its interactome confers structural plasticity and functional versatility
-
doi: 10.1038/srep02035
-
Malaney, P., Pathak, R. R., Xue, B., Uversky, V. N., and Dave, V. (2013). Intrinsic disorder in PTEN and its interactome confers structural plasticity and functional versatility. Sci. Rep. 3:2035. doi: 10.1038/srep02035
-
(2013)
Sci. Rep.
, vol.3
, pp. 2035
-
-
Malaney, P.1
Pathak, R.R.2
Xue, B.3
Uversky, V.N.4
Dave, V.5
-
93
-
-
84872334235
-
Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke
-
doi: 10.1016/j.neuroscience.2012.11.050
-
Mao, L., Jia, J., Zhou, X., Xiao, Y., Wang, Y., Mao, X., et al. (2013). Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke. Neuroscience 231, 272-281. doi: 10.1016/j.neuroscience.2012.11.050
-
(2013)
Neuroscience
, vol.231
, pp. 272-281
-
-
Mao, L.1
Jia, J.2
Zhou, X.3
Xiao, Y.4
Wang, Y.5
Mao, X.6
-
94
-
-
77955626857
-
Confirmation study of PTEN mutations among individuals with autism or developmental delays/mental retardation and macrocephaly
-
doi: 10.1002/aur.132
-
McBride, K. L., Varga, E. A., Pastore, M. T., Prior, T. W., Manickam, K., Atkin, J. F., et al. (2010). Confirmation study of PTEN mutations among individuals with autism or developmental delays/mental retardation and macrocephaly. Autism Res. 3, 137-141. doi: 10.1002/aur.132
-
(2010)
Autism Res.
, vol.3
, pp. 137-141
-
-
McBride, K.L.1
Varga, E.A.2
Pastore, M.T.3
Prior, T.W.4
Manickam, K.5
Atkin, J.F.6
-
95
-
-
85027931809
-
When overgrowth bumps into cancer: The PTEN-opathies
-
doi: 10.1002/j.1552-4876.2013.31364.x
-
Mester, J., and Eng, C. (2013). When overgrowth bumps into cancer: the PTEN-opathies. Am. J. Med. Genet. C Semin. Med. Genet. 163C, 114-121. doi: 10.1002/j.1552-4876.2013.31364.x
-
(2013)
Am. J. Med. Genet. C Semin. Med. Genet.
, vol.163 C
, pp. 114-121
-
-
Mester, J.1
Eng, C.2
-
96
-
-
79959270685
-
Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model
-
doi: 10.1038/ejhg.2011.20
-
Mester, J. L., Tilot, A. K., Rybicki, L. A., Frazier, T. W. 2nd., and Eng, C. (2011). Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model. Eur. J. Hum. Genet. 19, 763-768. doi: 10.1038/ejhg.2011.20
-
(2011)
Eur. J. Hum. Genet.
, vol.19
, pp. 763-768
-
-
Mester, J.L.1
Tilot, A.K.2
Rybicki, L.A.3
Frazier II, T.W.4
Eng, C.5
-
97
-
-
84858003974
-
PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma
-
doi: 10.1038/onc.2011.324
-
Molina, J. R., Agarwal, N. K., Morales, F. C., Hayashi, Y., Aldape, K. D., Cote, G., et al. (2012). PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma. Oncogene 31, 1264-1274. doi: 10.1038/onc.2011.324
-
(2012)
Oncogene
, vol.31
, pp. 1264-1274
-
-
Molina, J.R.1
Agarwal, N.K.2
Morales, F.C.3
Hayashi, Y.4
Aldape, K.D.5
Cote, G.6
-
98
-
-
79955746108
-
Different conformations of phosphatase and tensin homolog, deleted on chromosome 10 (PTEN) protein within the nucleus and cytoplasm of neurons
-
doi: 10.1371/journal.pone.0018857
-
Moncalero, V. L., Costanzo, R. V., Perandones, C., and Radrizzani, M. (2011). Different conformations of phosphatase and tensin homolog, deleted on chromosome 10 (PTEN) protein within the nucleus and cytoplasm of neurons. PloS ONE 6:e18857. doi: 10.1371/journal.pone.0018857
-
(2011)
PloS ONE
, vol.6
-
-
Moncalero, V.L.1
Costanzo, R.V.2
Perandones, C.3
Radrizzani, M.4
-
99
-
-
77954914419
-
Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2
-
doi: 10.1073/pnas.0911714107
-
Mund, T., and Pelham, H. R. B. (2010). Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2. Proc. Natl. Acad. Sci. U.S.A. 107, 11429-11434. doi: 10.1073/pnas.0911714107
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 11429-11434
-
-
Mund, T.1
Pelham, H.R.B.2
-
100
-
-
0032506011
-
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
-
doi: 10.1073/pnas.95.23.13513
-
Myers, M. P., Pass, I., Batty, I. H., Van der Kaay, J., Stolarov, J. P., Hemmings, B. A., et al. (1998). The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc. Natl. Acad. Sci. U.S.A. 95, 13513-13518. doi: 10.1073/pnas.95.23.13513
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 13513-13518
-
-
Myers, M.P.1
Pass, I.2
Batty, I.H.3
Van der Kaay, J.4
Stolarov, J.P.5
Hemmings, B.A.6
-
101
-
-
84888354888
-
Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium
-
doi: 10.1038/onc.2013.507. [Epub ahead of print]
-
Nguyen, H. N., Afkari, Y., Senoo, H., Sesaki, H., Devreotes, P. N., and Iijima, M. (2013). Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium. Oncogene. doi: 10.1038/onc.2013.507. [Epub ahead of print].
-
(2013)
Oncogene.
-
-
Nguyen, H.N.1
Afkari, Y.2
Senoo, H.3
Sesaki, H.4
Devreotes, P.N.5
Iijima, M.6
-
102
-
-
77955026640
-
PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons
-
doi: 10.1093/hmg/ddq226
-
Ning, K., Drepper, C., Valori, C. F., Ahsan, M., Wyles, M., Higginbottom, A., et al. (2010). PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons. Hum. Mol. Genet. 19, 3159-3168. doi: 10.1093/hmg/ddq226
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 3159-3168
-
-
Ning, K.1
Drepper, C.2
Valori, C.F.3
Ahsan, M.4
Wyles, M.5
Higginbottom, A.6
-
103
-
-
34548154756
-
Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain
-
doi: 10.1074/jbc.M611240200
-
Odriozola, L., Singh, G., Hoang, T., and Chan, A. M. (2007). Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain. J. Biol. Chem. 282, 23306-23315. doi: 10.1074/jbc.M611240200
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 23306-23315
-
-
Odriozola, L.1
Singh, G.2
Hoang, T.3
Chan, A.M.4
-
104
-
-
77956257633
-
Semaphorin 4D/Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons
-
doi: 10.1074/jbc.M110.147546
-
Oinuma, I., Ito, Y., Katoh, H., and Negishi, M. (2010). Semaphorin 4D/Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons. J. Biol. Chem. 285, 28200-28209. doi: 10.1074/jbc.M110.147546
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 28200-28209
-
-
Oinuma, I.1
Ito, Y.2
Katoh, H.3
Negishi, M.4
-
105
-
-
84872287369
-
Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes
-
doi: 10.1016/j.ajhg.2012.10.021
-
Orloff, M. S., He, X., Peterson, C., Chen, F., Chen, J.-L., Mester, J. L., et al. (2013). Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes. Am. J. Hum. Genet. 92, 76-80. doi: 10.1016/j.ajhg.2012.10.021
-
(2013)
Am. J. Hum. Genet.
, vol.92
, pp. 76-80
-
-
Orloff, M.S.1
He, X.2
Peterson, C.3
Chen, F.4
Chen, J.-L.5
Mester, J.L.6
-
106
-
-
58849124268
-
Novel PTEN mutations in neurodevelopmental disorders and macrocephaly
-
doi: 10.1111/j.1399-0004.2008.01074.x
-
Orrico, A., Galli, L., Buoni, S., Orsi, A., Vonella, G., and Sorrentino, V. (2009). Novel PTEN mutations in neurodevelopmental disorders and macrocephaly. Clin. Genet. 75, 195-198. doi: 10.1111/j.1399-0004.2008.01074.x
-
(2009)
Clin. Genet.
, vol.75
, pp. 195-198
-
-
Orrico, A.1
Galli, L.2
Buoni, S.3
Orsi, A.4
Vonella, G.5
Sorrentino, V.6
-
107
-
-
34447299716
-
The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN
-
doi: 10.1038/sj.emboj.7601763
-
Papakonstanti, E. A., Ridley, A. J., and Vanhaesebroeck, B. (2007). The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN. EMBO J. 26, 3050-3061. doi: 10.1038/sj.emboj.7601763
-
(2007)
EMBO J.
, vol.26
, pp. 3050-3061
-
-
Papakonstanti, E.A.1
Ridley, A.J.2
Vanhaesebroeck, B.3
-
108
-
-
55849108858
-
Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway
-
doi: 10.1126/science.1161566
-
Park, K. K., Liu, K., Hu, Y., Smith, P. D., Wang, C., Cai, B., et al. (2008). Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science 322, 963-966. doi: 10.1126/science.1161566
-
(2008)
Science
, vol.322
, pp. 963-966
-
-
Park, K.K.1
Liu, K.2
Hu, Y.3
Smith, P.D.4
Wang, C.5
Cai, B.6
-
109
-
-
78650905544
-
A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons
-
doi: 10.1016/j.mcn.2010.09.006
-
Perdigoto, A. L., Chaudhry, N., Barnes, G. N., Filbin, M. T., and Carter, B. D. (2011). A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons. Mol. Cell. Neurosci. 46, 235-244. doi: 10.1016/j.mcn.2010.09.006
-
(2011)
Mol. Cell. Neurosci.
, vol.46
, pp. 235-244
-
-
Perdigoto, A.L.1
Chaudhry, N.2
Barnes, G.N.3
Filbin, M.T.4
Carter, B.D.5
-
110
-
-
84890465438
-
Cowden syndrome and the PTEN hamartoma tumor syndrome: Systematic review and revised diagnostic criteria
-
doi: 10.1093/jnci/djt277
-
Pilarski, R., Burt, R., Kohlman, W., Pho, L., Shannon, K. M., and Swisher, E. (2013). Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria. J. Natl. Cancer Inst. 105, 1607-1616. doi: 10.1093/jnci/djt277
-
(2013)
J. Natl. Cancer Inst.
, vol.105
, pp. 1607-1616
-
-
Pilarski, R.1
Burt, R.2
Kohlman, W.3
Pho, L.4
Shannon, K.M.5
Swisher, E.6
-
111
-
-
40549118822
-
The nuclear affairs of PTEN
-
doi: 10.1242/jcs.022459
-
Planchon, S. M., Waite, K. A., and Eng, C. (2008). The nuclear affairs of PTEN. J. Cell Sci. 121, 249-253. doi: 10.1242/jcs.022459
-
(2008)
J. Cell Sci.
, vol.121
, pp. 249-253
-
-
Planchon, S.M.1
Waite, K.A.2
Eng, C.3
-
112
-
-
84866857904
-
The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells
-
doi: 10.1126/scisignal.2003084
-
Putz, U., Howitt, J., Doan, A., Goh, C.-P., Low, L.-H., Silke, J., et al. (2012). The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells. Sci. Signal. 5:ra70. doi: 10.1126/scisignal.2003084
-
(2012)
Sci. Signal.
, vol.5
-
-
Putz, U.1
Howitt, J.2
Doan, A.3
Goh, C.-P.4
Low, L.-H.5
Silke, J.6
-
113
-
-
1242284600
-
Regulation of cell migration by the C2 domain of the tumor suppressor PTEN
-
doi: 10.1126/science.1092089
-
Raftopoulou, M., Etienne-Manneville, S., Self, A., Nicholls, S., and Hall, A. (2004). Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. Science 303, 1179-1181. doi: 10.1126/science.1092089
-
(2004)
Science
, vol.303
, pp. 1179-1181
-
-
Raftopoulou, M.1
Etienne-Manneville, S.2
Self, A.3
Nicholls, S.4
Hall, A.5
-
114
-
-
58849102128
-
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN
-
doi: 10.1073/pnas.0811212106
-
Rahdar, M., Inoue, T., Meyer, T., Zhang, J., Vazquez, F., and Devreotes, P. N. (2009). A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc. Natl. Acad. Sci. U.S.A. 106, 480-485. doi: 10.1073/pnas.0811212106
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 480-485
-
-
Rahdar, M.1
Inoue, T.2
Meyer, T.3
Zhang, J.4
Vazquez, F.5
Devreotes, P.N.6
-
115
-
-
84874377202
-
Extracellular vesicles: Exosomes, microvesicles, and friends
-
doi: 10.1083/jcb.201211138
-
Raposo, G., and Stoorvogel, W. (2013). Extracellular vesicles: exosomes, microvesicles, and friends. J. Cell Biol. 200, 373-383. doi: 10.1083/jcb.201211138
-
(2013)
J. Cell Biol.
, vol.200
, pp. 373-383
-
-
Raposo, G.1
Stoorvogel, W.2
-
116
-
-
77957296246
-
A mutant form of PTEN linked to autism
-
doi: 10.1002/pro.483
-
Redfern, R. E., Daou, M. C., Li, L., Munson, M., Gericke, A., and Ross, A. H. (2010). A mutant form of PTEN linked to autism. Protein Sci. 19, 1948-1956. doi: 10.1002/pro.483
-
(2010)
Protein Sci.
, vol.19
, pp. 1948-1956
-
-
Redfern, R.E.1
Daou, M.C.2
Li, L.3
Munson, M.4
Gericke, A.5
Ross, A.H.6
-
117
-
-
39649095159
-
PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes
-
doi: 10.1021/bi702114w
-
Redfern, R. E., Redfern, D., Furgason, M. L., Munson, M., Ross, A. H., and Gericke, A. (2008). PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes. Biochemistry (Mosc.) 47, 2162-2171. doi: 10.1021/bi702114w
-
(2008)
Biochemistry (Mosc.)
, vol.47
, pp. 2162-2171
-
-
Redfern, R.E.1
Redfern, D.2
Furgason, M.L.3
Munson, M.4
Ross, A.H.5
Gericke, A.6
-
118
-
-
33845507061
-
Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease
-
doi: 10.1073/pnas.0606401103
-
Ries, V., Henchcliffe, C., Kareva, T., Rzhetskaya, M., Bland, R., During, M. J., et al. (2006). Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease. Proc. Natl. Acad. Sci. U.S.A. 103, 18757-18762. doi: 10.1073/pnas.0606401103
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 18757-18762
-
-
Ries, V.1
Henchcliffe, C.2
Kareva, T.3
Rzhetskaya, M.4
Bland, R.5
During, M.J.6
-
119
-
-
80053984176
-
A comprehensive functional analysis of PTEN mutations: Implications in tumor-and autism-related syndromes
-
doi: 10.1093/hmg/ddr337
-
Rodríguez-Escudero, I., Oliver, M. D., Andrés-Pons, A., Molina, M., Cid, V. J., and Pulido, R. (2011). A comprehensive functional analysis of PTEN mutations: implications in tumor-and autism-related syndromes. Hum. Mol. Genet. 20, 4132-4142. doi: 10.1093/hmg/ddr337
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 4132-4142
-
-
Rodríguez-Escudero, I.1
Oliver, M.D.2
Andrés-Pons, A.3
Molina, M.4
Cid, V.J.5
Pulido, R.6
-
120
-
-
60849132775
-
Phosphorylation keeps PTEN phosphatase closed for business
-
doi: 10.1073/pnas.0812473106
-
Ross, A. H., and Gericke, A. (2009). Phosphorylation keeps PTEN phosphatase closed for business. Proc. Natl. Acad. Sci. U.S.A. 106, 1297-1298. doi: 10.1073/pnas.0812473106
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 1297-1298
-
-
Ross, A.H.1
Gericke, A.2
-
121
-
-
15444373513
-
PTEN as an effector in the signaling of antimigratory G protein-coupled receptor
-
doi: 10.1073/pnas.0409784102
-
Sanchez, T., Thangada, S., Wu, M. T., Kontos, C. D., Wu, D., Wu, H., et al. (2005). PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc. Natl. Acad. Sci. U.S.A. 102, 4312-4317. doi: 10.1073/pnas.0409784102
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 4312-4317
-
-
Sanchez, T.1
Thangada, S.2
Wu, M.T.3
Kontos, C.D.4
Wu, D.5
Wu, H.6
-
122
-
-
33845999615
-
Essential role for nuclear PTEN in maintaining chromosomal integrity
-
doi: 10.1016/j.cell.2006.11.042
-
Shen, W. H., Balajee, A. S., Wang, J., Wu, H., Eng, C., Pandolfi, P. P., et al. (2007). Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128, 157-170. doi: 10.1016/j.cell.2006.11.042
-
(2007)
Cell
, vol.128
, pp. 157-170
-
-
Shen, W.H.1
Balajee, A.S.2
Wang, J.3
Wu, H.4
Eng, C.5
Pandolfi, P.P.6
-
123
-
-
84859593968
-
Membrane association of the PTEN tumor suppressor: Molecular details of the protein-membrane complex from SPR binding studies and neutron reflection
-
doi: 10.1371/journal.pone.0032591
-
Shenoy, S., Shekhar, P., Heinrich, F., Daou, M. C., Gericke, A., Ross, A. H., et al. (2012). Membrane association of the PTEN tumor suppressor: molecular details of the protein-membrane complex from SPR binding studies and neutron reflection. PLoS ONE 7:e32591. doi: 10.1371/journal.pone.0032591
-
(2012)
PLoS ONE
, vol.7
-
-
Shenoy, S.1
Shekhar, P.2
Heinrich, F.3
Daou, M.C.4
Gericke, A.5
Ross, A.H.6
-
125
-
-
84872170622
-
PTEN at a glance
-
doi: 10.1242/jcs.093765
-
Shi, Y., Paluch, B. E., Wang, X., and Jiang, X. (2012). PTEN at a glance. J. Cell Sci. 125, 4687-4692. doi: 10.1242/jcs.093765
-
(2012)
J. Cell Sci.
, vol.125
, pp. 4687-4692
-
-
Shi, Y.1
Paluch, B.E.2
Wang, X.3
Jiang, X.4
-
126
-
-
78651482046
-
Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner
-
doi: 10.1016/j.cell.2010.12.020
-
Song, M. S., Carracedo, A., Salmena, L., Song, S. J., Egia, A., Malumbres, M., et al. (2011). Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell 144, 187-199. doi: 10.1016/j.cell.2010.12.020
-
(2011)
Cell
, vol.144
, pp. 187-199
-
-
Song, M.S.1
Carracedo, A.2
Salmena, L.3
Song, S.J.4
Egia, A.5
Malumbres, M.6
-
127
-
-
53649106156
-
The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network
-
doi: 10.1038/nature07290
-
Song, M. S., Salmena, L., Carracedo, A., Egia, A., Lo-Coco, F., Teruya-Feldstein, J., et al. (2008). The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. Nature 455, 813-817. doi: 10.1038/nature07290
-
(2008)
Nature
, vol.455
, pp. 813-817
-
-
Song, M.S.1
Salmena, L.2
Carracedo, A.3
Egia, A.4
Lo-Coco, F.5
Teruya-Feldstein, J.6
-
128
-
-
84860217431
-
The functions and regulation of the PTEN tumour suppressor
-
doi: 10.1038/nrm3330
-
Song, M. S., Salmena, L., and Pandolfi, P. P. (2012). The functions and regulation of the PTEN tumour suppressor. Nat. Rev. Mol. Cell Biol. 13, 283-296. doi: 10.1038/nrm3330
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 283-296
-
-
Song, M.S.1
Salmena, L.2
Pandolfi, P.P.3
-
129
-
-
75749112450
-
Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles
-
doi: 10.1016/j.neulet.2009.12.078
-
Sonoda, Y., Mukai, H., Matsuo, K., Takahashi, M., Ono, Y., Maeda, K., et al. (2010). Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles. Neurosci. Lett. 471, 20-24. doi: 10.1016/j.neulet.2009.12.078
-
(2010)
Neurosci. Lett.
, vol.471
, pp. 20-24
-
-
Sonoda, Y.1
Mukai, H.2
Matsuo, K.3
Takahashi, M.4
Ono, Y.5
Maeda, K.6
-
130
-
-
84856904410
-
Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration
-
doi: 10.1113/jphysiol.2011.220236
-
Sperow, M., Berry, R. B., Bayazitov, I. T., Zhu, G., Baker, S. J., and Zakharenko, S. S. (2012). Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration. J. Physiol. 590, 777-792. doi: 10.1113/jphysiol.2011.220236
-
(2012)
J. Physiol.
, vol.590
, pp. 777-792
-
-
Sperow, M.1
Berry, R.B.2
Bayazitov, I.T.3
Zhu, G.4
Baker, S.J.5
Zakharenko, S.S.6
-
131
-
-
79961192077
-
The actin nucleating Arp2/3 complex contributes to the formation of axonal filopodia and branches through the regulation of actin patch precursors to filopodia
-
doi: 10.1002/dneu.20907
-
Spillane, M., Ketschek, A., Jones, S. L., Korobova, F., Marsick, B., Lanier, L., et al. (2011). The actin nucleating Arp2/3 complex contributes to the formation of axonal filopodia and branches through the regulation of actin patch precursors to filopodia. Dev. Neurobiol. 71, 747-758. doi: 10.1002/dneu.20907
-
(2011)
Dev. Neurobiol.
, vol.71
, pp. 747-758
-
-
Spillane, M.1
Ketschek, A.2
Jones, S.L.3
Korobova, F.4
Marsick, B.5
Lanier, L.6
-
132
-
-
1642512636
-
Synergy in tumor suppression by direct interaction of neutral endopeptidase with PTEN
-
doi: 10.1016/S1535-6108(03)00331-3
-
Sumitomo, M., Iwase, A., Zheng, R., Navarro, D., Kaminetzky, D., Shen, R., et al. (2004). Synergy in tumor suppression by direct interaction of neutral endopeptidase with PTEN. Cancer Cell 5, 67-78. doi: 10.1016/S1535-6108(03)00331-3
-
(2004)
Cancer Cell
, vol.5
, pp. 67-78
-
-
Sumitomo, M.1
Iwase, A.2
Zheng, R.3
Navarro, D.4
Kaminetzky, D.5
Shen, R.6
-
133
-
-
83555174832
-
Sustained axon regeneration induced by co-deletion of PTEN and SOCS3
-
doi: 10.1038/nature10594
-
Sun, F., Park, K. K., Belin, S., Wang, D., Lu, T., Chen, G., et al. (2011). Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature 480, 372-375. doi: 10.1038/nature10594
-
(2011)
Nature
, vol.480
, pp. 372-375
-
-
Sun, F.1
Park, K.K.2
Belin, S.3
Wang, D.4
Lu, T.5
Chen, G.6
-
134
-
-
84875270373
-
Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism
-
doi: 10.1073/pnas.1222803110
-
Takeuchi, K., Gertner, M. J., Zhou, J., Parada, L. F., Bennett, M. V. L., and Zukin, R. S. (2013). Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism. Proc. Natl. Acad. Sci. U.S.A. 110, 4738-4743. doi: 10.1073/pnas.1222803110
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 4738-4743
-
-
Takeuchi, K.1
Gertner, M.J.2
Zhou, J.3
Parada, L.F.4
Bennett, M.V.L.5
Zukin, R.S.6
-
135
-
-
0033575287
-
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway
-
doi: 10.1074/jbc.274.29.20693
-
Tamura, M., Gu, J., Danen, E. H., Takino, T., Miyamoto, S., and Yamada, K. M. (1999). PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J. Biol. Chem. 274, 20693-20703. doi: 10.1074/jbc.274.29.20693
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 20693-20703
-
-
Tamura, M.1
Gu, J.2
Danen, E.H.3
Takino, T.4
Miyamoto, S.5
Yamada, K.M.6
-
136
-
-
0032486198
-
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
-
doi: 10.1126/science.280.5369.1614
-
Tamura, M., Gu, J., Matsumoto, K., Aota, S., Parsons, R., and Yamada, K. M. (1998). Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280, 1614-1617. doi: 10.1126/science.280.5369.1614
-
(1998)
Science
, vol.280
, pp. 1614-1617
-
-
Tamura, M.1
Gu, J.2
Matsumoto, K.3
Aota, S.4
Parsons, R.5
Yamada, K.M.6
-
137
-
-
84865189134
-
Interference with the PTEN-MAST2 interaction by a viral protein leads to cellular relocalization of PTEN
-
doi: 10.1126/scisignal.2002941
-
Terrien, E., Chaffotte, A., Lafage, M., Khan, Z., Préhaud, C., Cordier, F., et al. (2012). Interference with the PTEN-MAST2 interaction by a viral protein leads to cellular relocalization of PTEN. Sci. Signal. 5:ra58. doi: 10.1126/scisignal.2002941
-
(2012)
Sci. Signal.
, vol.5
-
-
Terrien, E.1
Chaffotte, A.2
Lafage, M.3
Khan, Z.4
Préhaud, C.5
Cordier, F.6
-
138
-
-
84857718063
-
PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity
-
doi: 10.1126/scisignal.2002138
-
Tibarewal, P., Zilidis, G., Spinelli, L., Schurch, N., Maccario, H., Gray, A., et al. (2012). PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity. Sci. Signal. 5, ra18. doi: 10.1126/scisignal.2002138
-
(2012)
Sci. Signal.
, vol.5
-
-
Tibarewal, P.1
Zilidis, G.2
Spinelli, L.3
Schurch, N.4
McCario, H.5
Gray, A.6
-
139
-
-
33845977965
-
Ubiquitination regulates PTEN nuclear import and tumor suppression
-
doi: 10.1016/j.cell.2006.11.040
-
Trotman, L. C., Wang, X., Alimonti, A., Chen, Z., Teruya-Feldstein, J., Yang, H., et al. (2007). Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 128, 141-156. doi: 10.1016/j.cell.2006.11.040
-
(2007)
Cell
, vol.128
, pp. 141-156
-
-
Trotman, L.C.1
Wang, X.2
Alimonti, A.3
Chen, Z.4
Teruya-Feldstein, J.5
Yang, H.6
-
140
-
-
84880469585
-
PIP3 regulates spinule formation in dendritic spines during structural long-term potentiation
-
doi: 10.1523/JNEUROSCI.3122-12.2013
-
Ueda, Y., and Hayashi, Y. (2013). PIP3 regulates spinule formation in dendritic spines during structural long-term potentiation. J. Neurosci. 33, 11040-11047. doi: 10.1523/JNEUROSCI.3122-12.2013
-
(2013)
J. Neurosci.
, vol.33
, pp. 11040-11047
-
-
Ueda, Y.1
Hayashi, Y.2
-
141
-
-
37149046442
-
Function of PTEN during the formation and maintenance of neuronal circuits in the brain
-
doi: 10.1159/000109852
-
Van Diepen, M. T., and Eickholt, B. J. (2008). Function of PTEN during the formation and maintenance of neuronal circuits in the brain. Dev. Neurosci. 30, 59-64. doi: 10.1159/000109852
-
(2008)
Dev. Neurosci.
, vol.30
, pp. 59-64
-
-
Van Diepen, M.T.1
Eickholt, B.J.2
-
142
-
-
70349636462
-
MyosinV controls PTEN function and neuronal cell size
-
doi: 10.1038/ncb1961
-
Van Diepen, M. T., Parsons, M., Downes, C. P., Leslie, N. R., Hindges, R., and Eickholt, B. J. (2009). MyosinV controls PTEN function and neuronal cell size. Nat. Cell Biol. 11, 1191-1196. doi: 10.1038/ncb1961
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1191-1196
-
-
Van Diepen, M.T.1
Parsons, M.2
Downes, C.P.3
Leslie, N.R.4
Hindges, R.5
Eickholt, B.J.6
-
143
-
-
77951621262
-
The emerging mechanisms of isoform-specific PI3K signalling
-
doi: 10.1038/nrm2882
-
Vanhaesebroeck, B., Guillermet-Guibert, J., Graupera, M., and Bilanges, B. (2010). The emerging mechanisms of isoform-specific PI3K signalling. Nat. Rev. Mol. Cell Biol. 11, 329-341. doi: 10.1038/nrm2882
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 329-341
-
-
Vanhaesebroeck, B.1
Guillermet-Guibert, J.2
Graupera, M.3
Bilanges, B.4
-
144
-
-
84857406235
-
PI3K signalling: The path to discovery and understanding
-
doi: 10.1038/nrm3290
-
Vanhaesebroeck, B., Stephens, L., and Hawkins, P. (2012). PI3K signalling: the path to discovery and understanding. Nat. Rev. Mol. Cell Biol. 13, 195-203. doi: 10.1038/nrm3290
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 195-203
-
-
Vanhaesebroeck, B.1
Stephens, L.2
Hawkins, P.3
-
145
-
-
62149104335
-
The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly
-
doi: 10.1097/GIM.0b013e31818fd762
-
Varga, E. A., Pastore, M., Prior, T., Herman, G. E., and McBride, K. L. (2009). The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly. Genet. Med. 11, 111-117. doi: 10.1097/GIM.0b013e31818fd762
-
(2009)
Genet. Med.
, vol.11
, pp. 111-117
-
-
Varga, E.A.1
Pastore, M.2
Prior, T.3
Herman, G.E.4
McBride, K.L.5
-
146
-
-
33746225428
-
Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction
-
doi: 10.4161/cc.5.14.3005
-
Vazquez, F., and Devreotes, P. (2006). Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction. Cell Cycle 5, 1523-1527. doi: 10.4161/cc.5.14.3005
-
(2006)
Cell Cycle
, vol.5
, pp. 1523-1527
-
-
Vazquez, F.1
Devreotes, P.2
-
147
-
-
0035966127
-
Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex
-
doi: 10.1074/jbc.C100556200
-
Vazquez, F., Grossman, S. R., Takahashi, Y., Rokas, M. V., Nakamura, N., and Sellers, W. R. (2001). Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J. Biol. Chem. 276, 48627-48630. doi: 10.1074/jbc.C100556200
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 48627-48630
-
-
Vazquez, F.1
Grossman, S.R.2
Takahashi, Y.3
Rokas, M.V.4
Nakamura, N.5
Sellers, W.R.6
-
148
-
-
33644870152
-
Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane
-
doi: 10.1073/pnas.0510570103
-
Vazquez, F., Matsuoka, S., Sellers, W. R., Yanagida, T., Ueda, M., and Devreotes, P. N. (2006). Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. Proc. Natl. Acad. Sci. U.S.A. 103, 3633-3638. doi: 10.1073/pnas.0510570103
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 3633-3638
-
-
Vazquez, F.1
Matsuoka, S.2
Sellers, W.R.3
Yanagida, T.4
Ueda, M.5
Devreotes, P.N.6
-
149
-
-
17744386543
-
Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling
-
doi: 10.1242/dev.01720
-
Von Stein, W., Ramrath, A., Grimm, A., Muller-Borg, M., and Wodarz, A. (2005). Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling. Development 132, 1675-1686. doi: 10.1242/dev.01720
-
(2005)
Development
, vol.132
, pp. 1675-1686
-
-
Von Stein, W.1
Ramrath, A.2
Grimm, A.3
Muller-Borg, M.4
Wodarz, A.5
-
150
-
-
79952114000
-
The neurodevelopmental implications of PI3K signaling
-
doi: 10.1007/82_2010_82
-
Waite, K., and Eickholt, B. J. (2010). The neurodevelopmental implications of PI3K signaling. Curr. Top. Microbiol. Immunol. 346, 245-265. doi: 10.1007/82_2010_82
-
(2010)
Curr. Top. Microbiol. Immunol.
, vol.346
, pp. 245-265
-
-
Waite, K.1
Eickholt, B.J.2
-
151
-
-
84855588783
-
Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury
-
doi: 10.1371/journal.pone.0030012
-
Walker, C. L., Walker, M. J., Liu, N.-K., Risberg, E. C., Gao, X., Chen, J., et al. (2012). Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury. PloS ONE 7:e30012. doi: 10.1371/journal.pone.0030012
-
(2012)
PloS ONE
, vol.7
-
-
Walker, C.L.1
Walker, M.J.2
Liu, N.-K.3
Risberg, E.C.4
Gao, X.5
Chen, J.6
-
152
-
-
2342631914
-
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif
-
doi: 10.1042/BJ20031839
-
Walker, S. M., Leslie, N. R., Perera, N. M., Batty, I. H., and Downes, C. P. (2004). The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif. Biochem. J. 379, 301-307. doi: 10.1042/BJ20031839
-
(2004)
Biochem. J.
, vol.379
, pp. 301-307
-
-
Walker, S.M.1
Leslie, N.R.2
Perera, N.M.3
Batty, I.H.4
Downes, C.P.5
-
153
-
-
0037124108
-
Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection
-
doi: 10.1074/jbc.M111704200
-
Wei, W., Wang, X., and Kusiak, J. W. (2002). Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection. J. Biol. Chem. 277, 17649-17656. doi: 10.1074/jbc.M111704200
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 17649-17656
-
-
Wei, W.1
Wang, X.2
Kusiak, J.W.3
-
154
-
-
0037155727
-
P-Rex1, a PtdIns(3,4,5)P3-and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac
-
doi: 10.1016/S0092-8674(02)00663-3
-
Welch, H. C. E., Coadwell, W. J., Ellson, C. D., Ferguson, G. J., Andrews, S. R., Erdjument-Bromage, H., et al. (2002). P-Rex1, a PtdIns(3,4,5)P3-and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell 108, 809-821. doi: 10.1016/S0092-8674(02)00663-3
-
(2002)
Cell
, vol.108
, pp. 809-821
-
-
Welch, H.C.E.1
Coadwell, W.J.2
Ellson, C.D.3
Ferguson, G.J.4
Andrews, S.R.5
Erdjument-Bromage, H.6
-
155
-
-
84880642453
-
Autism spectrum disorder causes, mechanisms, and treatments: Focus on neuronal synapses
-
doi: 10.3389/fnmol.2013.00019
-
Won, H., Mah, W., and Kim, E. (2013). Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses. Front. Mol. Neurosci. 6:19. doi: 10.3389/fnmol.2013.00019
-
(2013)
Front. Mol. Neurosci.
, vol.6
, pp. 19
-
-
Won, H.1
Mah, W.2
Kim, E.3
-
156
-
-
84884189701
-
Drebrin contains a cryptic F-actin-bundling activity regulated by Cdk5 phosphorylation
-
doi: 10.1083/jcb.201303005
-
Worth, D. C., Daly, C. N., Geraldo, S., Oozeer, F., and Gordon-Weeks, P. R. (2013). Drebrin contains a cryptic F-actin-bundling activity regulated by Cdk5 phosphorylation. J. Cell Biol. 202, 793-806. doi: 10.1083/jcb.201303005
-
(2013)
J. Cell Biol.
, vol.202
, pp. 793-806
-
-
Worth, D.C.1
Daly, C.N.2
Geraldo, S.3
Oozeer, F.4
Gordon-Weeks, P.R.5
-
157
-
-
36749070993
-
PDZ domains of Par-3 as potential phosphoinositide signaling integrators
-
doi: 10.1016/j.molcel.2007.10.028
-
Wu, H., Feng, W., Chen, J., Chan, L. N., Huang, S., and Zhang, M. (2007). PDZ domains of Par-3 as potential phosphoinositide signaling integrators. Mol. Cell 28, 886-898. doi: 10.1016/j.molcel.2007.10.028
-
(2007)
Mol. Cell
, vol.28
, pp. 886-898
-
-
Wu, H.1
Feng, W.2
Chen, J.3
Chan, L.N.4
Huang, S.5
Zhang, M.6
-
158
-
-
0034636038
-
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2
-
doi: 10.1073/pnas.97.8.4233
-
Wu, X., Hepner, K., Castelino-Prabhu, S., Do, D., Kaye, M. B., Yuan, X. J., et al. (2000). Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. Proc. Natl. Acad. Sci. U.S.A. 97, 4233-4238. doi: 10.1073/pnas.97.8.4233
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 4233-4238
-
-
Wu, X.1
Hepner, K.2
Castelino-Prabhu, S.3
Do, D.4
Kaye, M.B.5
Yuan, X.J.6
-
159
-
-
0038311944
-
Phosphoinositide regulation of the actin cytoskeleton
-
doi: 10.1146/annurev.physiol.65.092101.142517
-
Yin, H. L., and Janmey, P. A. (2003). Phosphoinositide regulation of the actin cytoskeleton. Annu. Rev. Physiol. 65, 761-789. doi: 10.1146/annurev.physiol.65.092101.142517
-
(2003)
Annu. Rev. Physiol.
, vol.65
, pp. 761-789
-
-
Yin, H.L.1
Janmey, P.A.2
-
160
-
-
84865209815
-
A phosphatidylinositol lipids system, lamellipodin, and Ena/VASP regulate dynamic morphology of multipolar migrating cells in the developing cerebral cortex
-
doi: 10.1523/JNEUROSCI.0738-12.2012
-
Yoshinaga, S., Ohkubo, T., Sasaki, S., Nuriya, M., Ogawa, Y., Yasui, M., et al. (2012). A phosphatidylinositol lipids system, lamellipodin, and Ena/VASP regulate dynamic morphology of multipolar migrating cells in the developing cerebral cortex. J. Neurosci. 32, 11643-11656. doi: 10.1523/JNEUROSCI.0738-12.2012
-
(2012)
J. Neurosci.
, vol.32
, pp. 11643-11656
-
-
Yoshinaga, S.1
Ohkubo, T.2
Sasaki, S.3
Nuriya, M.4
Ogawa, Y.5
Yasui, M.6
-
161
-
-
84877117383
-
Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries
-
doi: 10.1523/JNEUROSCI.5661-12.2013
-
Zhang, S., Taghibiglou, C., Girling, K., Dong, Z., Lin, S.-Z., Lee, W., et al. (2013). Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries. J. Neurosci. 33, 7997-8008. doi: 10.1523/JNEUROSCI.5661-12.2013
-
(2013)
J. Neurosci.
, vol.33
, pp. 7997-8008
-
-
Zhang, S.1
Taghibiglou, C.2
Girling, K.3
Dong, Z.4
Lin, S.-Z.5
Lee, W.6
-
162
-
-
33845619414
-
Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules
-
doi: 10.1096/fj.06-5721fje
-
Zhang, X., Li, F., Bulloj, A., Zhang, Y.-W., Tong, G., Zhang, Z., et al. (2006). Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules. FASEB J. 20, 1272-1274. doi: 10.1096/fj.06-5721fje
-
(2006)
FASEB J.
, vol.20
, pp. 1272-1274
-
-
Zhang, X.1
Li, F.2
Bulloj, A.3
Zhang, Y.-W.4
Tong, G.5
Zhang, Z.6
-
163
-
-
84862208776
-
Functional analysis of the protein phosphatase activity of PTEN
-
doi: 10.1042/BJ20120098
-
Zhang, X. C., Piccini, A., Myers, M. P., Van Aelst, L., and Tonks, N. K. (2012a). Functional analysis of the protein phosphatase activity of PTEN. Biochem. J. 444, 457-464. doi: 10.1042/BJ20120098
-
(2012)
Biochem. J.
, vol.444
, pp. 457-464
-
-
Zhang, X.C.1
Piccini, A.2
Myers, M.P.3
Van Aelst, L.4
Tonks, N.K.5
-
164
-
-
84866393562
-
PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice
-
doi: 10.1093/brain/aws196
-
Zhang, Y., Granholm, A.-C., Huh, K., Shan, L., Diaz-Ruiz, O., Malik, N., et al. (2012b). PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice. Brain 135, 2736-2749. doi: 10.1093/brain/aws196
-
(2012)
Brain
, vol.135
, pp. 2736-2749
-
-
Zhang, Y.1
Granholm, A.-C.2
Huh, K.3
Shan, L.4
Diaz-Ruiz, O.5
Malik, N.6
-
165
-
-
60849109211
-
Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice
-
doi: 10.1523/JNEUROSCI.5685-08.2009
-
Zhou, J., Blundell, J., Ogawa, S., Kwon, C.-H., Zhang, W., Sinton, C., et al. (2009). Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J. Neurosci. 29, 1773-1783. doi: 10.1523/JNEUROSCI.5685-08.2009
-
(2009)
J. Neurosci.
, vol.29
, pp. 1773-1783
-
-
Zhou, J.1
Blundell, J.2
Ogawa, S.3
Kwon, C.-H.4
Zhang, W.5
Sinton, C.6
-
166
-
-
84868198811
-
PTEN signaling in autism spectrum disorders
-
doi: 10.1016/j.conb.2012.05.004
-
Zhou, J., and Parada, L. F. (2012). PTEN signaling in autism spectrum disorders. Curr. Opin. Neurobiol. 22, 873-879. doi: 10.1016/j.conb.2012.05.004
-
(2012)
Curr. Opin. Neurobiol.
, vol.22
, pp. 873-879
-
-
Zhou, J.1
Parada, L.F.2
-
167
-
-
33344476774
-
PTEN: A crucial mediator of mitochondria-dependent apoptosis
-
doi: 10.1007/s10495-006-3714-5
-
Zhu, Y., Hoell, P., Ahlemeyer, B., and Krieglstein, J. (2006). PTEN: a crucial mediator of mitochondria-dependent apoptosis. Apoptosis 11, 197-207. doi: 10.1007/s10495-006-3714-5
-
(2006)
Apoptosis
, vol.11
, pp. 197-207
-
-
Zhu, Y.1
Hoell, P.2
Ahlemeyer, B.3
Krieglstein, J.4
-
168
-
-
33846626477
-
Implication of PTEN in production of reactive oxygen species and neuronal death in in vitro models of stroke and Parkinson's disease
-
doi: 10.1016/j.neuint.2006.10.010
-
Zhu, Y., Hoell, P., Ahlemeyer, B., Sure, U., Bertalanffy, H., and Krieglstein, J. (2007). Implication of PTEN in production of reactive oxygen species and neuronal death in in vitro models of stroke and Parkinson's disease. Neurochem. Int. 50, 507-516. doi: 10.1016/j.neuint.2006.10.010
-
(2007)
Neurochem. Int.
, vol.50
, pp. 507-516
-
-
Zhu, Y.1
Hoell, P.2
Ahlemeyer, B.3
Sure, U.4
Bertalanffy, H.5
Krieglstein, J.6
-
169
-
-
79958073565
-
Ischemic preconditioning attenuates mitochondrial localization of PTEN induced by ischemia-reperfusion
-
doi: 10.1152/ajpheart.01138.2010
-
Zu, L., Zheng, X., Wang, B., Parajuli, N., Steenbergen, C., Becker, L. C., et al. (2011). Ischemic preconditioning attenuates mitochondrial localization of PTEN induced by ischemia-reperfusion. Am. J. Physiol. Heart Circ. Physiol. 300, H2177-H2186. doi: 10.1152/ajpheart.01138.2010
-
(2011)
Am. J. Physiol. Heart Circ. Physiol.
, vol.300
-
-
Zu, L.1
Zheng, X.2
Wang, B.3
Parajuli, N.4
Steenbergen, C.5
Becker, L.C.6
-
170
-
-
84884545941
-
Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury
-
doi: 10.1523/JNEUROSCI.2510-13.2013
-
Zukor, K., Belin, S., Wang, C., Keelan, N., Wang, X., and He, Z. (2013). Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury. J. Neurosci. 33, 15350-15361. doi: 10.1523/JNEUROSCI.2510-13.2013
-
(2013)
J. Neurosci.
, vol.33
, pp. 15350-15361
-
-
Zukor, K.1
Belin, S.2
Wang, C.3
Keelan, N.4
Wang, X.5
He, Z.6
|