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Volumn 7, Issue 1 APR, 2014, Pages

Subcellular targeting and dynamic regulation of PTEN: Implications for neuronal cells and neurological disorders

Author keywords

Membranes; Neuronal morphology; PI3K AKT mTOR; PTEN phosphohydrolase; Synaptic transmission

Indexed keywords

CELL MEMBRANE PROTEIN; ISOPROTEIN; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; UNCLASSIFIED DRUG;

EID: 84897460431     PISSN: 16625099     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnmol.2014.00023     Document Type: Review
Times cited : (68)

References (170)
  • 1
    • 84860162767 scopus 로고    scopus 로고
    • Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis
    • doi: 10.1523/JNEUROSCI.5462-11.2012
    • Amiri, A., Cho, W., Zhou, J., Birnbaum, S. G., Sinton, C. M., McKay, R. M., et al. (2012). Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis. J. Neurosci. 32, 5880-5890. doi: 10.1523/JNEUROSCI.5462-11.2012
    • (2012) J. Neurosci. , vol.32 , pp. 5880-5890
    • Amiri, A.1    Cho, W.2    Zhou, J.3    Birnbaum, S.G.4    Sinton, C.M.5    McKay, R.M.6
  • 2
    • 34249910593 scopus 로고    scopus 로고
    • An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells
    • doi: 10.1083/jcb.200609017
    • Aoki, K., Nakamura, T., Inoue, T., Meyer, T., and Matsuda, M. (2007). An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells. J. Cell Biol. 177, 817-827. doi: 10.1083/jcb.200609017
    • (2007) J. Cell Biol. , vol.177 , pp. 817-827
    • Aoki, K.1    Nakamura, T.2    Inoue, T.3    Meyer, T.4    Matsuda, M.5
  • 3
    • 73949117548 scopus 로고    scopus 로고
    • PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane
    • doi: 10.1038/nn.2462
    • Arendt, K. L., Royo, M., Fernández-Monreal, M., Knafo, S., Petrok, C. N., Martens, J. R., et al. (2010). PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane. Nat. Neurosci. 13, 36-44. doi: 10.1038/nn.2462
    • (2010) Nat. Neurosci. , vol.13 , pp. 36-44
    • Arendt, K.L.1    Royo, M.2    Fernández-Monreal, M.3    Knafo, S.4    Petrok, C.N.5    Martens, J.R.6
  • 4
    • 0035733762 scopus 로고    scopus 로고
    • Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
    • doi: 10.1038/ng782
    • Backman, S. A., Stambolic, V., Suzuki, A., Haight, J., Elia, A., Pretorius, J., et al. (2001). Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat. Genet. 29, 396-403. doi: 10.1038/ng782
    • (2001) Nat. Genet. , vol.29 , pp. 396-403
    • Backman, S.A.1    Stambolic, V.2    Suzuki, A.3    Haight, J.4    Elia, A.5    Pretorius, J.6
  • 5
    • 84880710673 scopus 로고    scopus 로고
    • Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress
    • doi: 10.1126/science.1236188
    • Bassi, C., Ho, J., Srikumar, T., Dowling, R. J. O., Gorrini, C., Miller, S. J., et al. (2013). Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress. Science 341, 395-399. doi: 10.1126/science.1236188
    • (2013) Science , vol.341 , pp. 395-399
    • Bassi, C.1    Ho, J.2    Srikumar, T.3    Dowling, R.J.O.4    Gorrini, C.5    Miller, S.J.6
  • 6
    • 84880124600 scopus 로고    scopus 로고
    • Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis
    • doi: 10.7554/eLife.00691
    • Bolduc, D., Rahdar, M., Tu-Sekine, B., Sivakumaren, S. C., Raben, D., Amzel, L. M., et al. (2013). Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis. Elife 2:e00691. doi: 10.7554/eLife.00691
    • (2013) Elife , vol.2
    • Bolduc, D.1    Rahdar, M.2    Tu-Sekine, B.3    Sivakumaren, S.C.4    Raben, D.5    Amzel, L.M.6
  • 7
    • 84887589243 scopus 로고    scopus 로고
    • Identification of PTEN at the ER and MAMs and its regulation of Ca(2+) signaling and apoptosis in a protein phosphatase-dependent manner
    • doi: 10.1038/cdd.2013.77
    • Bononi, A., Bonora, M., Marchi, S., Missiroli, S., Poletti, F., Giorgi, C., et al. (2013). Identification of PTEN at the ER and MAMs and its regulation of Ca(2+) signaling and apoptosis in a protein phosphatase-dependent manner. Cell Death Differ. 20, 1631-1643. doi: 10.1038/cdd.2013.77
    • (2013) Cell Death Differ. , vol.20 , pp. 1631-1643
    • Bononi, A.1    Bonora, M.2    Marchi, S.3    Missiroli, S.4    Poletti, F.5    Giorgi, C.6
  • 8
    • 20244367771 scopus 로고    scopus 로고
    • Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations
    • doi: 10.1136/jmg.2004.024646
    • Butler, M. G., Dasouki, M. J., Zhou, X.-P., Talebizadeh, Z., Brown, M., Takahashi, T. N., Miles, J. H., Wang, C. H., Stratton, R., Pilarski, R., et al. (2005). Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. J. Med. Genet. 42, 318-321. doi: 10.1136/jmg.2004.024646
    • (2005) J. Med. Genet. , vol.42 , pp. 318-321
    • Butler, M.G.1    Dasouki, M.J.2    Zhou, X.-P.3    Talebizadeh, Z.4    Brown, M.5    Takahashi, T.N.6    Miles, J.H.7    Wang, C.H.8    Stratton, R.9    Pilarski, R.10
  • 9
    • 34250812575 scopus 로고    scopus 로고
    • Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly
    • doi: 10.1002/ajmg.b.30493
    • Buxbaum, J. D., Cai, G., Chaste, P., Nygren, G., Goldsmith, J., Reichert, J., et al. (2007). Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B, 484-491. doi: 10.1002/ajmg.b.30493
    • (2007) Am. J. Med. Genet. B Neuropsychiatr. Genet. , vol.144 B , pp. 484-491
    • Buxbaum, J.D.1    Cai, G.2    Chaste, P.3    Nygren, G.4    Goldsmith, J.5    Reichert, J.6
  • 10
    • 84882657764 scopus 로고    scopus 로고
    • MC1R is a potent regulator of PTEN after UV exposure in melanocytes
    • doi: 10.1016/j.molcel.2013.08.010
    • Cao, J., Wan, L., Hacker, E., Dai, X., Lenna, S., Jimenez-Cervantes, C., et al. (2013). MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Mol. Cell 51, 409-422. doi: 10.1016/j.molcel.2013.08.010
    • (2013) Mol. Cell , vol.51 , pp. 409-422
    • Cao, J.1    Wan, L.2    Hacker, E.3    Dai, X.4    Lenna, S.5    Jimenez-Cervantes, C.6
  • 11
    • 0036382931 scopus 로고    scopus 로고
    • Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1
    • doi: 10.1016/S0006-291X(02)00928-2
    • Caselli, A., Mazzinghi, B., Camici, G., Manao, G., and Ramponi, G. (2002). Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1. Biochem. Biophys. Res. Commun. 296, 692-697. doi: 10.1016/S0006-291X(02)00928-2
    • (2002) Biochem. Biophys. Res. Commun. , vol.296 , pp. 692-697
    • Caselli, A.1    Mazzinghi, B.2    Camici, G.3    Manao, G.4    Ramponi, G.5
  • 12
    • 33645237488 scopus 로고    scopus 로고
    • PTEN couples Sema3A signalling to growth cone collapse
    • doi: 10.1242/jcs.02801
    • Chadborn, N. H., Ahmed, A. I., Holt, M. R., Prinjha, R., Dunn, G. A., Jones, G. E., et al. (2006). PTEN couples Sema3A signalling to growth cone collapse. J. Cell Sci. 119, 951-957. doi: 10.1242/jcs.02801
    • (2006) J. Cell Sci. , vol.119 , pp. 951-957
    • Chadborn, N.H.1    Ahmed, A.I.2    Holt, M.R.3    Prinjha, R.4    Dunn, G.A.5    Jones, G.E.6
  • 13
    • 77950440345 scopus 로고    scopus 로고
    • Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase
    • doi: 10.1073/pnas.0908899107
    • Chagpar, R. B., Links, P. H., Pastor, M. C., Furber, L. A., Hawrysh, A. D., Chamberlain, M. D., et al. (2010). Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. U.S.A. 107, 5471-5476. doi: 10.1073/pnas.0908899107
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 5471-5476
    • Chagpar, R.B.1    Links, P.H.2    Pastor, M.C.3    Furber, L.A.4    Hawrysh, A.D.5    Chamberlain, M.D.6
  • 14
    • 4143087008 scopus 로고    scopus 로고
    • Lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of PTEN in the detergent-resistant membrane fraction
    • doi: 10.1007/s00018-004-4127-7
    • Cheung, N. S., Choy, M. S., Halliwell, B., Teo, T. S., Bay, B. H., Lee, A. Y., et al. (2004). Lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of PTEN in the detergent-resistant membrane fraction. Cell Mol. Life Sci. 61, 1926-1934. doi: 10.1007/s00018-004-4127-7
    • (2004) Cell Mol. Life Sci. , vol.61 , pp. 1926-1934
    • Cheung, N.S.1    Choy, M.S.2    Halliwell, B.3    Teo, T.S.4    Bay, B.H.5    Lee, A.Y.6
  • 16
    • 33746731609 scopus 로고    scopus 로고
    • PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis
    • doi: 10.1016/j.neulet.2006.06.037
    • Choy, M. S., Bay, B. H., Cheng, H. C., and Cheung, N. S. (2006). PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis. Neurosci. Lett. 405, 120-125. doi: 10.1016/j.neulet.2006.06.037
    • (2006) Neurosci. Lett. , vol.405 , pp. 120-125
    • Choy, M.S.1    Bay, B.H.2    Cheng, H.C.3    Cheung, N.S.4
  • 17
    • 77954480424 scopus 로고    scopus 로고
    • PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons
    • doi: 10.1523/JNEUROSCI.6271-09.2010
    • Christie, K. J., Webber, C. A., Martinez, J. A., Singh, B., and Zochodne, D. W. (2010). PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons. J. Neurosci. 30, 9306-9315. doi: 10.1523/JNEUROSCI.6271-09.2010
    • (2010) J. Neurosci. , vol.30 , pp. 9306-9315
    • Christie, K.J.1    Webber, C.A.2    Martinez, J.A.3    Singh, B.4    Zochodne, D.W.5
  • 18
    • 20144384760 scopus 로고    scopus 로고
    • Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein
    • doi: 10.1158/0008-5472.CAN-05-0124
    • Chung, J.-H., Ginn-Pease, M. E., and Eng, C. (2005). Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein. Cancer Res. 65, 4108-4116. doi: 10.1158/0008-5472.CAN-05-0124
    • (2005) Cancer Res. , vol.65 , pp. 4108-4116
    • Chung, J.-H.1    Ginn-Pease, M.E.2    Eng, C.3
  • 19
    • 84858673050 scopus 로고    scopus 로고
    • Phosphatase and tensin homolog (PTEN) gene mutations and autism: Literature review and a case report of a patient with Cowden syndrome, autistic disorder, and epilepsy
    • doi: 10.1177/0883073811420296
    • Conti, S., Condò, M., Posar, A., Mari, F., Resta, N., Renieri, A., et al. (2012). Phosphatase and tensin homolog (PTEN) gene mutations and autism: literature review and a case report of a patient with Cowden syndrome, autistic disorder, and epilepsy. J. Child Neurol. 27, 392-397. doi: 10.1177/0883073811420296
    • (2012) J. Child Neurol. , vol.27 , pp. 392-397
    • Conti, S.1    Condò, M.2    Posar, A.3    Mari, F.4    Resta, N.5    Renieri, A.6
  • 20
    • 84886826594 scopus 로고    scopus 로고
    • mTOR complexes in neurodevelopmental and neuropsychiatric disorders
    • doi: 10.1038/nn.3546
    • Costa-Mattioli, M., and Monteggia, L. M. (2013). mTOR complexes in neurodevelopmental and neuropsychiatric disorders. Nat. Neurosci. 16, 1537-1543. doi: 10.1038/nn.3546
    • (2013) Nat. Neurosci. , vol.16 , pp. 1537-1543
    • Costa-Mattioli, M.1    Monteggia, L.M.2
  • 21
    • 70349168685 scopus 로고    scopus 로고
    • Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons
    • doi: 10.1371/journal.pone.0007027
    • Diaz-Ruiz, O., Zapata, A., Shan, L., Zhang, Y., Tomac, A. C., Malik, N., et al. (2009). Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons. PloS ONE 4:e7027. doi: 10.1371/journal.pone.0007027
    • (2009) PloS ONE , vol.4
    • Diaz-Ruiz, O.1    Zapata, A.2    Shan, L.3    Zhang, Y.4    Tomac, A.C.5    Malik, N.6
  • 22
    • 84896699377 scopus 로고    scopus 로고
    • Inhibition of phosphatase and tensin homolog deleted on chromosome 10 decreases rat cortical neuron injury and blood-brain barrier permeability, and improves neurological functional recovery in traumatic brain injury model
    • doi: 10.1371/journal.pone.0080429
    • Ding, J., Guo, J., Yuan, Q., Yuan, F., Chen, H., and Tian, H. (2013). Inhibition of phosphatase and tensin homolog deleted on chromosome 10 decreases rat cortical neuron injury and blood-brain barrier permeability, and improves neurological functional recovery in traumatic brain injury model. PloS ONE 8:e80429. doi: 10.1371/journal.pone.0080429
    • (2013) PloS ONE , vol.8
    • Ding, J.1    Guo, J.2    Yuan, Q.3    Yuan, F.4    Chen, H.5    Tian, H.6
  • 23
    • 33749836234 scopus 로고    scopus 로고
    • Phosphoinositides in cell regulation and membrane dynamics
    • doi: 10.1038/nature05185
    • Di Paolo, G., and De Camilli, P. (2006). Phosphoinositides in cell regulation and membrane dynamics. Nature 443, 651-657. doi: 10.1038/nature05185
    • (2006) Nature , vol.443 , pp. 651-657
    • Di Paolo, G.1    De Camilli, P.2
  • 24
    • 80052668585 scopus 로고    scopus 로고
    • Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models
    • doi: 10.1096/fj.11-181958
    • Domanskyi, A., Geissler, C., Vinnikov, I. A., Alter, H., Schober, A., Vogt, M. A., et al. (2011). Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models. FASEB J. 25, 2898-2910. doi: 10.1096/fj.11-181958
    • (2011) FASEB J. , vol.25 , pp. 2898-2910
    • Domanskyi, A.1    Geissler, C.2    Vinnikov, I.A.3    Alter, H.4    Schober, A.5    Vogt, M.A.6
  • 25
    • 0030902595 scopus 로고    scopus 로고
    • Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid-and human amylin-induced toxicity
    • Doré, S., Kar, S., and Quirion, R. (1997). Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid-and human amylin-induced toxicity. Proc. Natl. Acad. Sci. U.S.A. 94, 4772-4777.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 4772-4777
    • Doré, S.1    Kar, S.2    Quirion, R.3
  • 26
    • 75949103435 scopus 로고    scopus 로고
    • E3 ligase Nedd4 promotes axon branching by downregulating PTEN
    • doi: 10.1016/j.neuron.2010.01.017
    • Drinjakovic, J., Jung, H., Campbell, D. S., Strochlic, L., Dwivedy, A., and Holt, C. E. (2010). E3 ligase Nedd4 promotes axon branching by downregulating PTEN. Neuron 65, 341-357. doi: 10.1016/j.neuron.2010.01.017
    • (2010) Neuron , vol.65 , pp. 341-357
    • Drinjakovic, J.1    Jung, H.2    Campbell, D.S.3    Strochlic, L.4    Dwivedy, A.5    Holt, C.E.6
  • 27
    • 41149165141 scopus 로고    scopus 로고
    • Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase
    • doi: 10.1371/journal.pone.0000869
    • Eickholt, B. J., Ahmed, A. I., Davies, M., Papakonstanti, E. A., Pearce, W., Starkey, M. L., et al. (2007). Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase. PLoS ONE 2:e869. doi: 10.1371/journal.pone.0000869
    • (2007) PLoS ONE , vol.2
    • Eickholt, B.J.1    Ahmed, A.I.2    Davies, M.3    Papakonstanti, E.A.4    Pearce, W.5    Starkey, M.L.6
  • 28
    • 0042316755 scopus 로고    scopus 로고
    • PTEN: One gene, many syndromes
    • doi: 10.1002/humu.10257
    • Eng, C. (2003). PTEN: one gene, many syndromes. Hum. Mutat. 22, 183-198. doi: 10.1002/humu.10257
    • (2003) Hum. Mutat. , vol.22 , pp. 183-198
    • Eng, C.1
  • 29
    • 84865542459 scopus 로고    scopus 로고
    • Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240
    • doi: 10.1073/pnas.1211962109
    • Fenton, T. R., Nathanson, D., Ponte de Albuquerque, C., Kuga, D., Iwanami, A., Dang, J., et al. (2012). Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proc. Natl. Acad. Sci. U.S.A. 109, 14164-14169. doi: 10.1073/pnas.1211962109
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 14164-14169
    • Fenton, T.R.1    Nathanson, D.2    Ponte de Albuquerque, C.3    Kuga, D.4    Iwanami, A.5    Dang, J.6
  • 30
    • 69949170092 scopus 로고    scopus 로고
    • Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a
    • doi: 10.1126/science.1173569
    • Fine, B., Hodakoski, C., Koujak, S., Su, T., Saal, L. H., Maurer, M., et al. (2009). Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science 325, 1261-1265. doi: 10.1126/science.1173569
    • (2009) Science , vol.325 , pp. 1261-1265
    • Fine, B.1    Hodakoski, C.2    Koujak, S.3    Su, T.4    Saal, L.H.5    Maurer, M.6
  • 31
    • 37849027524 scopus 로고    scopus 로고
    • Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities
    • doi: 10.1016/j.neuroscience.2007.10.048
    • Fraser, M. M., Bayazitov, I. T., Zakharenko, S. S., and Baker, S. J. (2008). Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. Neuroscience 151, 476-488. doi: 10.1016/j.neuroscience.2007.10.048
    • (2008) Neuroscience , vol.151 , pp. 476-488
    • Fraser, M.M.1    Bayazitov, I.T.2    Zakharenko, S.S.3    Baker, S.J.4
  • 32
    • 7444264727 scopus 로고    scopus 로고
    • Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo
    • doi: 10.1158/0008-5472.CAN-04-2487
    • Fraser, M. M., Zhu, X., Kwon, C.-H., Uhlmann, E. J., Gutmann, D. H., and Baker, S. J. (2004). Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo. Cancer Res. 64, 7773-7779. doi: 10.1158/0008-5472.CAN-04-2487
    • (2004) Cancer Res. , vol.64 , pp. 7773-7779
    • Fraser, M.M.1    Zhu, X.2    Kwon, C.-H.3    Uhlmann, E.J.4    Gutmann, D.H.5    Baker, S.J.6
  • 33
    • 0041450058 scopus 로고    scopus 로고
    • PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and-independent mechanisms
    • doi: 10.1016/S1535-6108(03)00021-7
    • Freeman, D. J., Li, A. G., Wei, G., Li, H.-H., Kertesz, N., Lesche, R., et al. (2003). PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and-independent mechanisms. Cancer Cell 3, 117-130. doi: 10.1016/S1535-6108(03)00021-7
    • (2003) Cancer Cell , vol.3 , pp. 117-130
    • Freeman, D.J.1    Li, A.G.2    Wei, G.3    Li, H.-H.4    Kertesz, N.5    Lesche, R.6
  • 34
    • 84878288766 scopus 로고    scopus 로고
    • RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms
    • doi: 10.1016/j.cell.2013.04.031
    • Fritsch, R., de Krijger, I., Fritsch, K., George, R., Reason, B., Kumar, M. S., et al. (2013). RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms. Cell 153, 1050-1063. doi: 10.1016/j.cell.2013.04.031
    • (2013) Cell , vol.153 , pp. 1050-1063
    • Fritsch, R.1    de Krijger, I.2    Fritsch, K.3    George, R.4    Reason, B.5    Kumar, M.S.6
  • 35
    • 84886810676 scopus 로고    scopus 로고
    • Extracellular vesicles as mediators of neuron-glia communication
    • doi: 10.3389/fncel.2013.00182
    • Frühbeis, C., Fröhlich, D., Kuo, W. P., and Krämer-Albers, E.-M. (2013). Extracellular vesicles as mediators of neuron-glia communication. Front. Cell. Neurosci. 7:182. doi: 10.3389/fncel.2013.00182
    • (2013) Front. Cell. Neurosci. , vol.7 , pp. 182
    • Frühbeis, C.1    Fröhlich, D.2    Kuo, W.P.3    Krämer-Albers, E.-M.4
  • 36
    • 80855132485 scopus 로고    scopus 로고
    • New insights into the role of mitochondria-associated endoplasmic reticulum membrane
    • doi: 10.1016/B978-0-12-386033-0.00002-5
    • Fujimoto, M., and Hayashi, T. (2011). New insights into the role of mitochondria-associated endoplasmic reticulum membrane. Int. Rev. Cell Mol. Biol. 292, 73-117. doi: 10.1016/B978-0-12-386033-0.00002-5
    • (2011) Int. Rev. Cell Mol. Biol. , vol.292 , pp. 73-117
    • Fujimoto, M.1    Hayashi, T.2
  • 37
    • 84880823162 scopus 로고    scopus 로고
    • Regulation of the tumor suppressor PTEN through exosomes: A diagnostic potential for prostate cancer
    • doi: 10.1371/journal.pone.0070047
    • Gabriel, K., Ingram, A., Austin, R., Kapoor, A., Tang, D., Majeed, F., et al. (2013). Regulation of the tumor suppressor PTEN through exosomes: a diagnostic potential for prostate cancer. PloS ONE 8:e70047. doi: 10.1371/journal.pone.0070047
    • (2013) PloS ONE , vol.8
    • Gabriel, K.1    Ingram, A.2    Austin, R.3    Kapoor, A.4    Tang, D.5    Majeed, F.6
  • 38
    • 84885434025 scopus 로고    scopus 로고
    • More than one ring to bind them all: Recent insights into the structure of the axon
    • doi: 10.1002/dneu.22100
    • Gallo, G. (2013). More than one ring to bind them all: recent insights into the structure of the axon. Dev. Neurobiol. 73, 799-805. doi: 10.1002/dneu.22100
    • (2013) Dev. Neurobiol. , vol.73 , pp. 799-805
    • Gallo, G.1
  • 39
    • 80052275615 scopus 로고    scopus 로고
    • PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains
    • doi: 10.1073/pnas.1019386108
    • Gao, X., Lowry, P. R., Zhou, X., Depry, C., Wei, Z., Wong, G. W., et al. (2011). PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains. Proc. Natl. Acad. Sci. U.S.A. 108, 14509-14514. doi: 10.1073/pnas.1019386108
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 14509-14514
    • Gao, X.1    Lowry, P.R.2    Zhou, X.3    Depry, C.4    Wei, Z.5    Wong, G.W.6
  • 40
    • 33748319341 scopus 로고    scopus 로고
    • Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs
    • doi: 10.1091/mbc.E06-05-0380
    • Gil, A., Andrés-Pons, A., Fernéndez, E., Valiente, M., Torres, J., Cervera, J., et al. (2006). Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs. Mol. Biol. Cell 17, 4002-4013. doi: 10.1091/mbc.E06-05-0380
    • (2006) Mol. Biol. Cell , vol.17 , pp. 4002-4013
    • Gil, A.1    Andrés-Pons, A.2    Fernéndez, E.3    Valiente, M.4    Torres, J.5    Cervera, J.6
  • 41
    • 0033843623 scopus 로고    scopus 로고
    • Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors
    • doi: 10.1016/S0002-9440(10)65040-7
    • Gimm, O., Perren, A., Weng, L. P., Marsh, D. J., Yeh, J. J., Ziebold, U., et al. (2000). Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors. Am. J. Pathol. 156, 1693-1700. doi: 10.1016/S0002-9440(10)65040-7
    • (2000) Am. J. Pathol. , vol.156 , pp. 1693-1700
    • Gimm, O.1    Perren, A.2    Weng, L.P.3    Marsh, D.J.4    Yeh, J.J.5    Ziebold, U.6
  • 42
    • 84890081732 scopus 로고    scopus 로고
    • Nuclear trafficking of Pten after brain injury leads to neuron survival not death
    • doi: 10.1016/j.expneurol.2013.11.017
    • Goh, C.-P., Putz, U., Howitt, J., Low, L.-H., Gunnersen, J., Bye, N., et al. (2013). Nuclear trafficking of Pten after brain injury leads to neuron survival not death. Exp. Neurol. 252C, 37-46. doi: 10.1016/j.expneurol.2013.11.017
    • (2013) Exp. Neurol. , vol.252 C , pp. 37-46
    • Goh, C.-P.1    Putz, U.2    Howitt, J.3    Low, L.-H.4    Gunnersen, J.5    Bye, N.6
  • 44
    • 24744459879 scopus 로고    scopus 로고
    • Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines
    • doi: 10.1002/jnr.20550
    • Goswami, R., Singh, D., Phillips, G., Kilkus, J., and Dawson, G. (2005). Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines. J. Neurosci. Res. 81, 541-550. doi: 10.1002/jnr.20550
    • (2005) J. Neurosci. Res. , vol.81 , pp. 541-550
    • Goswami, R.1    Singh, D.2    Phillips, G.3    Kilkus, J.4    Dawson, G.5
  • 45
    • 16244391770 scopus 로고    scopus 로고
    • Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
    • doi: 10.1111/j.1471-4159.2004.02949.x
    • Griffin, R. J., Moloney, A., Kelliher, M., Johnston, J. A., Ravid, R., Dockery, P., et al. (2005). Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J. Neurochem. 93, 105-117. doi: 10.1111/j.1471-4159.2004.02949.x
    • (2005) J. Neurochem. , vol.93 , pp. 105-117
    • Griffin, R.J.1    Moloney, A.2    Kelliher, M.3    Johnston, J.A.4    Ravid, R.5    Dockery, P.6
  • 46
    • 0035824396 scopus 로고    scopus 로고
    • Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo
    • doi: 10.1126/science.1065518
    • Groszer, M., Erickson, R., Scripture-Adams, D. D., Lesche, R., Trumpp, A., Zack, J. A., et al. (2001). Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 294, 2186-2189. doi: 10.1126/science.1065518
    • (2001) Science , vol.294 , pp. 2186-2189
    • Groszer, M.1    Erickson, R.2    Scripture-Adams, D.D.3    Lesche, R.4    Trumpp, A.5    Zack, J.A.6
  • 47
    • 0026487365 scopus 로고
    • Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase
    • doi: 10.1016/0304-3940(92)90774-2
    • Hanger, D. P., Hughes, K., Woodgett, J. R., Brion, J. P., and Anderton, B. H. (1992). Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase. Neurosci. Lett. 147, 58-62. doi: 10.1016/0304-3940(92)90774-2
    • (1992) Neurosci. Lett. , vol.147 , pp. 58-62
    • Hanger, D.P.1    Hughes, K.2    Woodgett, J.R.3    Brion, J.P.4    Anderton, B.H.5
  • 48
    • 33751297031 scopus 로고    scopus 로고
    • Signalling through Class I PI3Ks in mammalian cells
    • doi: 10.1042/BST0340647
    • Hawkins, P. T., Anderson, K. E., Davidson, K., and Stephens, L. R. (2006). Signalling through Class I PI3Ks in mammalian cells. Biochem. Soc. Trans. 34, 647-662. doi: 10.1042/BST0340647
    • (2006) Biochem. Soc. Trans. , vol.34 , pp. 647-662
    • Hawkins, P.T.1    Anderson, K.E.2    Davidson, K.3    Stephens, L.R.4
  • 49
    • 84893732333 scopus 로고    scopus 로고
    • PTEN knockdown alters dendritic spine/protrusion morphology, not density
    • doi: 10.1002/cne.23488
    • Haws, M. E., Jaramillo, T. C., Espinosa-Becerra, F., Widman, A., Stuber, G. D., Sparta, D. R., et al. (2014). PTEN knockdown alters dendritic spine/protrusion morphology, not density. J. Comp. Neurol. 522, 1171-1190. doi: 10.1002/cne.23488
    • (2014) J. Comp. Neurol. , vol.522 , pp. 1171-1190
    • Haws, M.E.1    Jaramillo, T.C.2    Espinosa-Becerra, F.3    Widman, A.4    Stuber, G.D.5    Sparta, D.R.6
  • 50
    • 0029825623 scopus 로고    scopus 로고
    • Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex
    • Hayashi, K., Ishikawa, R., Ye, L. H., He, X. L., Takata, K., Kohama, K., et al. (1996). Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex. J. Neurosci. 16, 7161-7170.
    • (1996) J. Neurosci. , vol.16 , pp. 7161-7170
    • Hayashi, K.1    Ishikawa, R.2    Ye, L.H.3    He, X.L.4    Takata, K.5    Kohama, K.6
  • 51
    • 84877337663 scopus 로고    scopus 로고
    • Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models
    • doi: 10.1073/pnas.1300677110
    • Hedskog, L., Pinho, C. M., Filadi, R., Ronnback, A., Hertwig, L., Wiehager, B., et al. (2013). Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models. Proc. Natl. Acad. Sci. U.S.A. 110, 7916-7921. doi: 10.1073/pnas.1300677110
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 7916-7921
    • Hedskog, L.1    Pinho, C.M.2    Filadi, R.3    Ronnback, A.4    Hertwig, L.5    Wiehager, B.6
  • 52
    • 84880554229 scopus 로고    scopus 로고
    • Differential role of PTEN phosphatase in chemotactic growth cone guidance
    • doi: 10.1074/jbc.C113.487066
    • Henle, S. J., Carlstrom, L. P., Cheever, T. R., and Henley, J. R. (2013). Differential role of PTEN phosphatase in chemotactic growth cone guidance. J. Biol. Chem. 288, 20837-20842. doi: 10.1074/jbc.C113.487066
    • (2013) J. Biol. Chem. , vol.288 , pp. 20837-20842
    • Henle, S.J.1    Carlstrom, L.P.2    Cheever, T.R.3    Henley, J.R.4
  • 53
    • 79956300659 scopus 로고    scopus 로고
    • Asymmetric PI(3,4,5)P3 and Akt signaling mediates chemotaxis of axonal growth cones
    • doi: 10.1523/JNEUROSCI.0216-11.2011
    • Henle, S. J., Wang, G., Liang, E., Wu, M., Poo, M.-M., and Henley, J. R. (2011). Asymmetric PI(3,4,5)P3 and Akt signaling mediates chemotaxis of axonal growth cones. J. Neurosci. 31, 7016-7027. doi: 10.1523/JNEUROSCI.0216-11.2011
    • (2011) J. Neurosci. , vol.31 , pp. 7016-7027
    • Henle, S.J.1    Wang, G.2    Liang, E.3    Wu, M.4    Poo, M.-M.5    Henley, J.R.6
  • 54
    • 84892832761 scopus 로고    scopus 로고
    • Biochemical screening and PTEN mutation analysis in individuals with autism spectrum disorders and macrocephaly
    • doi: 10.1038/ejhg.2013.114
    • Hobert, J. A., Embacher, R., Mester, J. L., Frazier, T. W. 2nd., and Eng, C. (2014). Biochemical screening and PTEN mutation analysis in individuals with autism spectrum disorders and macrocephaly. Eur. J. Hum. Genet. 22, 273-276. doi: 10.1038/ejhg.2013.114
    • (2014) Eur. J. Hum. Genet. , vol.22 , pp. 273-276
    • Hobert, J.A.1    Embacher, R.2    Mester, J.L.3    Frazier II, T.W.4    Eng, C.5
  • 55
    • 84891945711 scopus 로고    scopus 로고
    • Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis
    • doi: 10.1073/pnas.1213773111
    • Hodakoski, C., Hopkins, B. D., Barrows, D., Mense, S. M., Keniry, M., Anderson, K. E., et al. (2014). Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis. Proc. Natl. Acad. Sci. U.S.A. 111, 155-160. doi: 10.1073/pnas.1213773111
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 155-160
    • Hodakoski, C.1    Hopkins, B.D.2    Barrows, D.3    Mense, S.M.4    Keniry, M.5    Anderson, K.E.6
  • 56
    • 84880737776 scopus 로고    scopus 로고
    • A secreted PTEN phosphatase that enters cells to alter signaling and survival
    • doi: 10.1126/science.1234907
    • Hopkins, B. D., Fine, B., Steinbach, N., Dendy, M., Rapp, Z., Shaw, J., et al. (2013). A secreted PTEN phosphatase that enters cells to alter signaling and survival. Science 341, 399-402. doi: 10.1126/science.1234907
    • (2013) Science , vol.341 , pp. 399-402
    • Hopkins, B.D.1    Fine, B.2    Steinbach, N.3    Dendy, M.4    Rapp, Z.5    Shaw, J.6
  • 57
    • 84863012466 scopus 로고    scopus 로고
    • Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia
    • doi: 10.1083/jcb.201105009
    • Howitt, J., Lackovic, J., Low, L.-H., Naguib, A., Macintyre, A., Goh, C.-P., et al. (2012). Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. J. Cell Biol. 196, 29-36. doi: 10.1083/jcb.201105009
    • (2012) J. Cell Biol. , vol.196 , pp. 29-36
    • Howitt, J.1    Lackovic, J.2    Low, L.-H.3    Naguib, A.4    McIntyre, A.5    Goh, C.-P.6
  • 58
    • 84863336040 scopus 로고    scopus 로고
    • SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane
    • doi: 10.1038/ncomms1919
    • Huang, J., Yan, J., Zhang, J., Zhu, S., Wang, Y., Shi, T., et al. (2012). SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nat. Commun. 3, 911. doi: 10.1038/ncomms1919.
    • (2012) Nat. Commun. , vol.3 , pp. 911
    • Huang, J.1    Yan, J.2    Zhang, J.3    Zhu, S.4    Wang, Y.5    Shi, T.6
  • 59
    • 77954874401 scopus 로고    scopus 로고
    • GSK3 signalling in neural development
    • doi: 10.1038/nrn2870
    • Hur, E.-M., and Zhou, F.-Q. (2010). GSK3 signalling in neural development. Nat. Rev. Neurosci. 11, 539-551. doi: 10.1038/nrn2870
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 539-551
    • Hur, E.-M.1    Zhou, F.-Q.2
  • 60
    • 84887305258 scopus 로고    scopus 로고
    • Coordinate regulation of mature dopaminergic axon morphology by macroautophagy and the PTEN signaling pathway
    • doi: 10.1371/journal.pgen.1003845
    • Inoue, K., Rispoli, J., Yang, L., Macleod, D., Beal, M. F., Klann, E., et al. (2013). Coordinate regulation of mature dopaminergic axon morphology by macroautophagy and the PTEN signaling pathway. PLoS Genet. 9:e1003845. doi: 10.1371/journal.pgen.1003845
    • (2013) PLoS Genet. , vol.9
    • Inoue, K.1    Rispoli, J.2    Yang, L.3    McLeod, D.4    Beal, M.F.5    Klann, E.6
  • 61
    • 77955850746 scopus 로고    scopus 로고
    • PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression
    • doi: 10.1038/emboj.2010.160
    • Jurado, S., Benoist, M., Lario, A., Knafo, S., Petrok, C. N., and Esteban, J. A. (2010). PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression. EMBO J. 29, 2827-2840. doi: 10.1038/emboj.2010.160
    • (2010) EMBO J. , vol.29 , pp. 2827-2840
    • Jurado, S.1    Benoist, M.2    Lario, A.3    Knafo, S.4    Petrok, C.N.5    Esteban, J.A.6
  • 62
    • 84881335837 scopus 로고    scopus 로고
    • Optogenetic control of PIP3: PIP3 is sufficient to induce the actin-based active part of growth cones and is regulated via endocytosis
    • doi: 10.1371/journal.pone.0070861
    • Kakumoto, T., and Nakata, T. (2013). Optogenetic control of PIP3: PIP3 is sufficient to induce the actin-based active part of growth cones and is regulated via endocytosis. PloS ONE 8:e70861. doi: 10.1371/journal.pone.0070861
    • (2013) PloS ONE , vol.8
    • Kakumoto, T.1    Nakata, T.2
  • 63
    • 84876817056 scopus 로고    scopus 로고
    • Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration
    • doi: 10.1073/pnas.1220755110
    • Karunarathne, W. K. A., Giri, L., Patel, A. K., Venkatesh, K. V., and Gautam, N. (2013). Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration. Proc. Natl. Acad. Sci. U.S.A. 110, E1575-1583. doi: 10.1073/pnas.1220755110
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110
    • Karunarathne, W.K.A.1    Giri, L.2    Patel, A.K.3    Venkatesh, K.V.4    Gautam, N.5
  • 64
    • 84872001794 scopus 로고    scopus 로고
    • PNUTS functions as a proto-oncogene by sequestering PTEN
    • doi: 10.1158/0008-5472.CAN-12-1394
    • Kavela, S., Shinde, S. R., Ratheesh, R., Viswakalyan, K., Bashyam, M. D., Gowrishankar, S., et al. (2013). PNUTS functions as a proto-oncogene by sequestering PTEN. Cancer Res. 73, 205-214. doi: 10.1158/0008-5472.CAN-12-1394
    • (2013) Cancer Res. , vol.73 , pp. 205-214
    • Kavela, S.1    Shinde, S.R.2    Ratheesh, R.3    Viswakalyan, K.4    Bashyam, M.D.5    Gowrishankar, S.6
  • 65
    • 33646751445 scopus 로고    scopus 로고
    • PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3
    • doi: 10.1016/j.febslet.2006.04.064
    • Kerr, F., Rickle, A., Nayeem, N., Brandner, S., Cowburn, R. F., and Lovestone, S. (2006). PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3. FEBS Lett. 580, 3121-3128. doi: 10.1016/j.febslet.2006.04.064
    • (2006) FEBS Lett. , vol.580 , pp. 3121-3128
    • Kerr, F.1    Rickle, A.2    Nayeem, N.3    Brandner, S.4    Cowburn, R.F.5    Lovestone, S.6
  • 66
    • 77956568206 scopus 로고    scopus 로고
    • Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia
    • doi: 10.1523/JNEUROSCI.1740-10.2010
    • Ketschek, A., and Gallo, G. (2010). Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia. J. Neurosci. 30, 12185-12197. doi: 10.1523/JNEUROSCI.1740-10.2010
    • (2010) J. Neurosci. , vol.30 , pp. 12185-12197
    • Ketschek, A.1    Gallo, G.2
  • 67
    • 80054977111 scopus 로고    scopus 로고
    • PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility
    • doi: 10.1038/nn.2937
    • Kim, J.-I., Lee, H.-R., Sim, S., Baek, J., Yu, N.-K., Choi, J.-H., et al. (2011a). PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility. Nat. Neurosci. 14, 1447-1454. doi: 10.1038/nn.2937
    • (2011) Nat. Neurosci. , vol.14 , pp. 1447-1454
    • Kim, J.-I.1    Lee, H.-R.2    Sim, S.3    Baek, J.4    Yu, N.-K.5    Choi, J.-H.6
  • 68
    • 79959403545 scopus 로고    scopus 로고
    • Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells
    • doi: 10.1128/MCB.01323-10
    • Kim, J.-S., Xu, X., Li, H., Solomon, D., Lane, W. S., Jin, T., et al. (2011b). Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells. Mol. Cell. Biol. 31, 2756-2771. doi: 10.1128/MCB.01323-10
    • (2011) Mol. Cell. Biol. , vol.31 , pp. 2756-2771
    • Kim, J.-S.1    Xu, X.2    Li, H.3    Solomon, D.4    Lane, W.S.5    Jin, T.6
  • 69
    • 79551690481 scopus 로고    scopus 로고
    • Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis
    • doi: 10.1093/brain/awq345
    • Kirby, J., Ning, K., Ferraiuolo, L., Heath, P. R., Ismail, A., Kuo, S.-W., et al. (2011). Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis. Brain 134, 506-517. doi: 10.1093/brain/awq345
    • (2011) Brain , vol.134 , pp. 506-517
    • Kirby, J.1    Ning, K.2    Ferraiuolo, L.3    Heath, P.R.4    Ismail, A.5    Kuo, S.-W.6
  • 70
    • 84874097245 scopus 로고    scopus 로고
    • Macrocephaly as a clinical indicator of genetic subtypes in autism
    • doi: 10.1002/aur.1266
    • Klein, S., Sharifi-Hannauer, P., and Martinez-Agosto, J. A. (2013). Macrocephaly as a clinical indicator of genetic subtypes in autism. Autism Res. 6, 51-56. doi: 10.1002/aur.1266
    • (2013) Autism Res. , vol.6 , pp. 51-56
    • Klein, S.1    Sharifi-Hannauer, P.2    Martinez-Agosto, J.A.3
  • 71
    • 5044244482 scopus 로고    scopus 로고
    • Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics
    • doi: 10.1016/j.devcel.2004.07.024
    • Krause, M., Leslie, J. D., Stewart, M., Lafuente, E. M., Valderrama, F., Jagannathan, R., et al. (2004). Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Dev. Cell 7, 571-583. doi: 10.1016/j.devcel.2004.07.024
    • (2004) Dev. Cell , vol.7 , pp. 571-583
    • Krause, M.1    Leslie, J.D.2    Stewart, M.3    Lafuente, E.M.4    Valderrama, F.5    Jagannathan, R.6
  • 72
    • 84881099545 scopus 로고    scopus 로고
    • Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN
    • doi: 10.1371/journal.pone.0071957
    • Kreis, P., Hendricusdottir, R., Kay, L., Papageorgiou, I. E., van Diepen, M., Mack, T., et al. (2013). Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN. PLoS ONE 8:e71957. doi: 10.1371/journal.pone.0071957
    • (2013) PLoS ONE , vol.8
    • Kreis, P.1    Hendricusdottir, R.2    Kay, L.3    Papageorgiou, I.E.4    van Diepen, M.5    Mack, T.6
  • 73
    • 77955293704 scopus 로고    scopus 로고
    • Regulation of PTEN in neurons by myosin-based transport mechanisms
    • doi: 10.1016/j.advenzreg.2009.10.014
    • Kreis, P., van Diepen, M. T., and Eickholt, B. J. (2010). Regulation of PTEN in neurons by myosin-based transport mechanisms. Adv. Enzyme Regul. 50, 119-124. doi: 10.1016/j.advenzreg.2009.10.014
    • (2010) Adv. Enzyme Regul. , vol.50 , pp. 119-124
    • Kreis, P.1    van Diepen, M.T.2    Eickholt, B.J.3
  • 74
    • 18244392475 scopus 로고    scopus 로고
    • Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices
    • doi: 10.1016/S1097-2765(02)00434-3
    • Krugmann, S., Anderson, K. E., Ridley, S. H., Risso, N., McGregor, A., Coadwell, J., et al. (2002). Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Mol. Cell 9, 95-108. doi: 10.1016/S1097-2765(02)00434-3
    • (2002) Mol. Cell , vol.9 , pp. 95-108
    • Krugmann, S.1    Anderson, K.E.2    Ridley, S.H.3    Risso, N.4    McGregor, A.5    Coadwell, J.6
  • 75
    • 78149253527 scopus 로고    scopus 로고
    • NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration
    • doi: 10.1186/1750-1326-5-49
    • Kwak, Y.-D., Ma, T., Diao, S., Zhang, X., Chen, Y., Hsu, J., et al. (2010). NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration. Mol. Neurodegener. 5, 49. doi: 10.1186/1750-1326-5-49
    • (2010) Mol. Neurodegener. , vol.5 , pp. 49
    • Kwak, Y.-D.1    Ma, T.2    Diao, S.3    Zhang, X.4    Chen, Y.5    Hsu, J.6
  • 76
    • 33646142995 scopus 로고    scopus 로고
    • Pten regulates neuronal arborization and social interaction in mice
    • doi: 10.1016/j.neuron.2006.03.023
    • Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., et al. (2006). Pten regulates neuronal arborization and social interaction in mice. Neuron 50, 377-388. doi: 10.1016/j.neuron.2006.03.023
    • (2006) Neuron , vol.50 , pp. 377-388
    • Kwon, C.-H.1    Luikart, B.W.2    Powell, C.M.3    Zhou, J.4    Matheny, S.A.5    Zhang, W.6
  • 77
    • 0035734381 scopus 로고    scopus 로고
    • Pten regulates neuronal soma size: A mouse model of Lhermitte-Duclos disease
    • doi: 10.1038/ng781
    • Kwon, C. H., Zhu, X., Zhang, J., Knoop, L. L., Tharp, R., Smeyne, R. J., et al. (2001). Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat. Genet. 29, 404-411. doi: 10.1038/ng781
    • (2001) Nat. Genet. , vol.29 , pp. 404-411
    • Kwon, C.H.1    Zhu, X.2    Zhang, J.3    Knoop, L.L.4    Tharp, R.5    Smeyne, R.J.6
  • 78
    • 34548817013 scopus 로고    scopus 로고
    • Cowden syndrome and Bannayan Riley Ruvalcaba syndrome represent one condition with variable expression and age-related penetrance: Results of a clinical study of PTEN mutation carriers
    • doi: 10.1136/jmg.2007.049981
    • Lachlan, K. L., Lucassen, A. M., Bunyan, D., and Temple, I. K. (2007). Cowden syndrome and Bannayan Riley Ruvalcaba syndrome represent one condition with variable expression and age-related penetrance: results of a clinical study of PTEN mutation carriers. J. Med. Genet. 44, 579-585. doi: 10.1136/jmg.2007.049981
    • (2007) J. Med. Genet. , vol.44 , pp. 579-585
    • Lachlan, K.L.1    Lucassen, A.M.2    Bunyan, D.3    Temple, I.K.4
  • 80
    • 0033615538 scopus 로고    scopus 로고
    • Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
    • doi: 10.1016/S0092-8674(00)81663-3
    • Lee, J. O., Yang, H., Georgescu, M. M., Di Cristofano, A., Maehama, T., Shi, Y., et al. (1999). Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 99, 323-334. doi: 10.1016/S0092-8674(00)81663-3
    • (1999) Cell , vol.99 , pp. 323-334
    • Lee, J.O.1    Yang, H.2    Georgescu, M.M.3    Di Cristofano, A.4    Maehama, T.5    Shi, Y.6
  • 81
    • 51849167782 scopus 로고    scopus 로고
    • Understanding PTEN regulation: PIP2, polarity and protein stability
    • doi: 10.1038/onc.2008.243
    • Leslie, N. R., Batty, I. H., Maccario, H., Davidson, L., and Downes, C. P. (2008). Understanding PTEN regulation: PIP2, polarity and protein stability. Oncogene 27, 5464-5476. doi: 10.1038/onc.2008.243
    • (2008) Oncogene , vol.27 , pp. 5464-5476
    • Leslie, N.R.1    Batty, I.H.2    McCario, H.3    Davidson, L.4    Downes, C.P.5
  • 82
    • 20244379418 scopus 로고    scopus 로고
    • Regulation of PTEN by Rho small GTPases
    • doi: 10.1038/ncb1236
    • Li, Z., Dong, X., Dong, X., Wang, Z., Liu, W., Deng, N., et al. (2005). Regulation of PTEN by Rho small GTPases. Nat. Cell Biol. 7, 399-404. doi: 10.1038/ncb1236
    • (2005) Nat. Cell Biol. , vol.7 , pp. 399-404
    • Li, Z.1    Dong, X.2    Dong, X.3    Wang, Z.4    Liu, W.5    Deng, N.6
  • 83
    • 27844535741 scopus 로고    scopus 로고
    • Class reunion: PTEN joins the nuclear crew
    • doi: 10.1038/sj.onc.1209089
    • Lian, Z., and Di Cristofano, A. (2005). Class reunion: PTEN joins the nuclear crew. Oncogene 24, 7394-7400. doi: 10.1038/sj.onc.1209089
    • (2005) Oncogene , vol.24 , pp. 7394-7400
    • Lian, Z.1    Di Cristofano, A.2
  • 84
    • 79960038559 scopus 로고    scopus 로고
    • Distinct functional outputs of PTEN signalling are controlled by dynamic association with beta-arrestins
    • doi: 10.1038/emboj.2011.178
    • Lima-Fernandes, E., Enslen, H., Camand, E., Kotelevets, L., Boularan, C., Achour, L., et al. (2011). Distinct functional outputs of PTEN signalling are controlled by dynamic association with beta-arrestins. EMBO J. 30, 2557-2568. doi: 10.1038/emboj.2011.178
    • (2011) EMBO J. , vol.30 , pp. 2557-2568
    • Lima-Fernandes, E.1    Enslen, H.2    Camand, E.3    Kotelevets, L.4    Boularan, C.5    Achour, L.6
  • 85
    • 84860389181 scopus 로고    scopus 로고
    • A mosaic activating mutation in AKT1 associated with the Proteus syndrome
    • doi: 10.1056/NEJMoa1104017
    • Lindhurst, M. J., Sapp, J. C., Teer, J. K., Johnston, J. J., Finn, E. M., Peters, K., et al. (2011). A mosaic activating mutation in AKT1 associated with the Proteus syndrome. N. Engl. J. Med. 365, 611-619. doi: 10.1056/NEJMoa1104017
    • (2011) N. Engl. J. Med. , vol.365 , pp. 611-619
    • Lindhurst, M.J.1    Sapp, J.C.2    Teer, J.K.3    Johnston, J.J.4    Finn, E.M.5    Peters, K.6
  • 86
    • 33845972919 scopus 로고    scopus 로고
    • Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression
    • doi: 10.1242/jcs.000133
    • Lindsay, Y., McCoull, D., Davidson, L., Leslie, N. R., Fairservice, A., Gray, A., et al. (2006). Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression. J. Cell Sci. 119, 5160-5168. doi: 10.1242/jcs.000133
    • (2006) J. Cell Sci. , vol.119 , pp. 5160-5168
    • Lindsay, Y.1    McCoull, D.2    Davidson, L.3    Leslie, N.R.4    Fairservice, A.5    Gray, A.6
  • 87
    • 77956187905 scopus 로고    scopus 로고
    • PTEN deletion enhances the regenerative ability of adult corticospinal neurons
    • doi: 10.1038/nn.2603
    • Liu, K., Lu, Y., Lee, J. K., Samara, R., Willenberg, R., Sears-Kraxberger, I., et al. (2010). PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat. Neurosci. 13, 1075-1081. doi: 10.1038/nn.2603
    • (2010) Nat. Neurosci. , vol.13 , pp. 1075-1081
    • Liu, K.1    Lu, Y.2    Lee, J.K.3    Samara, R.4    Willenberg, R.5    Sears-Kraxberger, I.6
  • 88
    • 79952770185 scopus 로고    scopus 로고
    • Pten knockdown in vivo increases excitatory drive onto dentate granule cells
    • doi: 10.1523/JNEUROSCI.0061-11.2011
    • Luikart, B. W., Schnell, E., Washburn, E. K., Bensen, A. L., Tovar, K. R., and Westbrook, G. L. (2011). Pten knockdown in vivo increases excitatory drive onto dentate granule cells. J. Neurosci. 31, 4345-4354. doi: 10.1523/JNEUROSCI.0061-11.2011
    • (2011) J. Neurosci. , vol.31 , pp. 4345-4354
    • Luikart, B.W.1    Schnell, E.2    Washburn, E.K.3    Bensen, A.L.4    Tovar, K.R.5    Westbrook, G.L.6
  • 89
    • 84873381777 scopus 로고    scopus 로고
    • Defining the membrane-associated state of the PTEN tumor suppressor protein
    • doi: 10.1016/j.bpj.2012.12.002
    • Lumb, C. N., and Sansom, M. S. P. (2013). Defining the membrane-associated state of the PTEN tumor suppressor protein. Biophys. J. 104, 613-621. doi: 10.1016/j.bpj.2012.12.002
    • (2013) Biophys. J. , vol.104 , pp. 613-621
    • Lumb, C.N.1    Sansom, M.S.P.2
  • 90
    • 84872395057 scopus 로고    scopus 로고
    • Neuron-intrinsic inhibitors of axon regeneration: PTEN and SOCS3
    • doi: 10.1016/B978-0-12-398309-1.00008-1
    • Luo, X., and Park, K. K. (2012). Neuron-intrinsic inhibitors of axon regeneration: PTEN and SOCS3. Int. Rev. Neurobiol. 105, 141-173. doi: 10.1016/B978-0-12-398309-1.00008-1
    • (2012) Int. Rev. Neurobiol. , vol.105 , pp. 141-173
    • Luo, X.1    Park, K.K.2
  • 91
    • 77951234781 scopus 로고    scopus 로고
    • Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress
    • doi: 10.1074/jbc.M109.072280
    • Maccario, H., Perera, N. M., Gray, A., Downes, C. P., and Leslie, N. R. (2010). Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress. J. Biol. Chem. 285, 12620-12628. doi: 10.1074/jbc.M109.072280
    • (2010) J. Biol. Chem. , vol.285 , pp. 12620-12628
    • McCario, H.1    Perera, N.M.2    Gray, A.3    Downes, C.P.4    Leslie, N.R.5
  • 92
    • 84879619834 scopus 로고    scopus 로고
    • Intrinsic disorder in PTEN and its interactome confers structural plasticity and functional versatility
    • doi: 10.1038/srep02035
    • Malaney, P., Pathak, R. R., Xue, B., Uversky, V. N., and Dave, V. (2013). Intrinsic disorder in PTEN and its interactome confers structural plasticity and functional versatility. Sci. Rep. 3:2035. doi: 10.1038/srep02035
    • (2013) Sci. Rep. , vol.3 , pp. 2035
    • Malaney, P.1    Pathak, R.R.2    Xue, B.3    Uversky, V.N.4    Dave, V.5
  • 93
    • 84872334235 scopus 로고    scopus 로고
    • Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke
    • doi: 10.1016/j.neuroscience.2012.11.050
    • Mao, L., Jia, J., Zhou, X., Xiao, Y., Wang, Y., Mao, X., et al. (2013). Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke. Neuroscience 231, 272-281. doi: 10.1016/j.neuroscience.2012.11.050
    • (2013) Neuroscience , vol.231 , pp. 272-281
    • Mao, L.1    Jia, J.2    Zhou, X.3    Xiao, Y.4    Wang, Y.5    Mao, X.6
  • 94
    • 77955626857 scopus 로고    scopus 로고
    • Confirmation study of PTEN mutations among individuals with autism or developmental delays/mental retardation and macrocephaly
    • doi: 10.1002/aur.132
    • McBride, K. L., Varga, E. A., Pastore, M. T., Prior, T. W., Manickam, K., Atkin, J. F., et al. (2010). Confirmation study of PTEN mutations among individuals with autism or developmental delays/mental retardation and macrocephaly. Autism Res. 3, 137-141. doi: 10.1002/aur.132
    • (2010) Autism Res. , vol.3 , pp. 137-141
    • McBride, K.L.1    Varga, E.A.2    Pastore, M.T.3    Prior, T.W.4    Manickam, K.5    Atkin, J.F.6
  • 95
    • 85027931809 scopus 로고    scopus 로고
    • When overgrowth bumps into cancer: The PTEN-opathies
    • doi: 10.1002/j.1552-4876.2013.31364.x
    • Mester, J., and Eng, C. (2013). When overgrowth bumps into cancer: the PTEN-opathies. Am. J. Med. Genet. C Semin. Med. Genet. 163C, 114-121. doi: 10.1002/j.1552-4876.2013.31364.x
    • (2013) Am. J. Med. Genet. C Semin. Med. Genet. , vol.163 C , pp. 114-121
    • Mester, J.1    Eng, C.2
  • 96
    • 79959270685 scopus 로고    scopus 로고
    • Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model
    • doi: 10.1038/ejhg.2011.20
    • Mester, J. L., Tilot, A. K., Rybicki, L. A., Frazier, T. W. 2nd., and Eng, C. (2011). Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model. Eur. J. Hum. Genet. 19, 763-768. doi: 10.1038/ejhg.2011.20
    • (2011) Eur. J. Hum. Genet. , vol.19 , pp. 763-768
    • Mester, J.L.1    Tilot, A.K.2    Rybicki, L.A.3    Frazier II, T.W.4    Eng, C.5
  • 97
    • 84858003974 scopus 로고    scopus 로고
    • PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma
    • doi: 10.1038/onc.2011.324
    • Molina, J. R., Agarwal, N. K., Morales, F. C., Hayashi, Y., Aldape, K. D., Cote, G., et al. (2012). PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma. Oncogene 31, 1264-1274. doi: 10.1038/onc.2011.324
    • (2012) Oncogene , vol.31 , pp. 1264-1274
    • Molina, J.R.1    Agarwal, N.K.2    Morales, F.C.3    Hayashi, Y.4    Aldape, K.D.5    Cote, G.6
  • 98
    • 79955746108 scopus 로고    scopus 로고
    • Different conformations of phosphatase and tensin homolog, deleted on chromosome 10 (PTEN) protein within the nucleus and cytoplasm of neurons
    • doi: 10.1371/journal.pone.0018857
    • Moncalero, V. L., Costanzo, R. V., Perandones, C., and Radrizzani, M. (2011). Different conformations of phosphatase and tensin homolog, deleted on chromosome 10 (PTEN) protein within the nucleus and cytoplasm of neurons. PloS ONE 6:e18857. doi: 10.1371/journal.pone.0018857
    • (2011) PloS ONE , vol.6
    • Moncalero, V.L.1    Costanzo, R.V.2    Perandones, C.3    Radrizzani, M.4
  • 99
    • 77954914419 scopus 로고    scopus 로고
    • Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2
    • doi: 10.1073/pnas.0911714107
    • Mund, T., and Pelham, H. R. B. (2010). Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2. Proc. Natl. Acad. Sci. U.S.A. 107, 11429-11434. doi: 10.1073/pnas.0911714107
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 11429-11434
    • Mund, T.1    Pelham, H.R.B.2
  • 100
    • 0032506011 scopus 로고    scopus 로고
    • The lipid phosphatase activity of PTEN is critical for its tumor supressor function
    • doi: 10.1073/pnas.95.23.13513
    • Myers, M. P., Pass, I., Batty, I. H., Van der Kaay, J., Stolarov, J. P., Hemmings, B. A., et al. (1998). The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc. Natl. Acad. Sci. U.S.A. 95, 13513-13518. doi: 10.1073/pnas.95.23.13513
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 13513-13518
    • Myers, M.P.1    Pass, I.2    Batty, I.H.3    Van der Kaay, J.4    Stolarov, J.P.5    Hemmings, B.A.6
  • 101
    • 84888354888 scopus 로고    scopus 로고
    • Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium
    • doi: 10.1038/onc.2013.507. [Epub ahead of print]
    • Nguyen, H. N., Afkari, Y., Senoo, H., Sesaki, H., Devreotes, P. N., and Iijima, M. (2013). Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium. Oncogene. doi: 10.1038/onc.2013.507. [Epub ahead of print].
    • (2013) Oncogene.
    • Nguyen, H.N.1    Afkari, Y.2    Senoo, H.3    Sesaki, H.4    Devreotes, P.N.5    Iijima, M.6
  • 102
    • 77955026640 scopus 로고    scopus 로고
    • PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons
    • doi: 10.1093/hmg/ddq226
    • Ning, K., Drepper, C., Valori, C. F., Ahsan, M., Wyles, M., Higginbottom, A., et al. (2010). PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons. Hum. Mol. Genet. 19, 3159-3168. doi: 10.1093/hmg/ddq226
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 3159-3168
    • Ning, K.1    Drepper, C.2    Valori, C.F.3    Ahsan, M.4    Wyles, M.5    Higginbottom, A.6
  • 103
    • 34548154756 scopus 로고    scopus 로고
    • Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain
    • doi: 10.1074/jbc.M611240200
    • Odriozola, L., Singh, G., Hoang, T., and Chan, A. M. (2007). Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain. J. Biol. Chem. 282, 23306-23315. doi: 10.1074/jbc.M611240200
    • (2007) J. Biol. Chem. , vol.282 , pp. 23306-23315
    • Odriozola, L.1    Singh, G.2    Hoang, T.3    Chan, A.M.4
  • 104
    • 77956257633 scopus 로고    scopus 로고
    • Semaphorin 4D/Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons
    • doi: 10.1074/jbc.M110.147546
    • Oinuma, I., Ito, Y., Katoh, H., and Negishi, M. (2010). Semaphorin 4D/Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons. J. Biol. Chem. 285, 28200-28209. doi: 10.1074/jbc.M110.147546
    • (2010) J. Biol. Chem. , vol.285 , pp. 28200-28209
    • Oinuma, I.1    Ito, Y.2    Katoh, H.3    Negishi, M.4
  • 105
    • 84872287369 scopus 로고    scopus 로고
    • Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes
    • doi: 10.1016/j.ajhg.2012.10.021
    • Orloff, M. S., He, X., Peterson, C., Chen, F., Chen, J.-L., Mester, J. L., et al. (2013). Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes. Am. J. Hum. Genet. 92, 76-80. doi: 10.1016/j.ajhg.2012.10.021
    • (2013) Am. J. Hum. Genet. , vol.92 , pp. 76-80
    • Orloff, M.S.1    He, X.2    Peterson, C.3    Chen, F.4    Chen, J.-L.5    Mester, J.L.6
  • 106
    • 58849124268 scopus 로고    scopus 로고
    • Novel PTEN mutations in neurodevelopmental disorders and macrocephaly
    • doi: 10.1111/j.1399-0004.2008.01074.x
    • Orrico, A., Galli, L., Buoni, S., Orsi, A., Vonella, G., and Sorrentino, V. (2009). Novel PTEN mutations in neurodevelopmental disorders and macrocephaly. Clin. Genet. 75, 195-198. doi: 10.1111/j.1399-0004.2008.01074.x
    • (2009) Clin. Genet. , vol.75 , pp. 195-198
    • Orrico, A.1    Galli, L.2    Buoni, S.3    Orsi, A.4    Vonella, G.5    Sorrentino, V.6
  • 107
    • 34447299716 scopus 로고    scopus 로고
    • The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN
    • doi: 10.1038/sj.emboj.7601763
    • Papakonstanti, E. A., Ridley, A. J., and Vanhaesebroeck, B. (2007). The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN. EMBO J. 26, 3050-3061. doi: 10.1038/sj.emboj.7601763
    • (2007) EMBO J. , vol.26 , pp. 3050-3061
    • Papakonstanti, E.A.1    Ridley, A.J.2    Vanhaesebroeck, B.3
  • 108
    • 55849108858 scopus 로고    scopus 로고
    • Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway
    • doi: 10.1126/science.1161566
    • Park, K. K., Liu, K., Hu, Y., Smith, P. D., Wang, C., Cai, B., et al. (2008). Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science 322, 963-966. doi: 10.1126/science.1161566
    • (2008) Science , vol.322 , pp. 963-966
    • Park, K.K.1    Liu, K.2    Hu, Y.3    Smith, P.D.4    Wang, C.5    Cai, B.6
  • 109
    • 78650905544 scopus 로고    scopus 로고
    • A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons
    • doi: 10.1016/j.mcn.2010.09.006
    • Perdigoto, A. L., Chaudhry, N., Barnes, G. N., Filbin, M. T., and Carter, B. D. (2011). A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons. Mol. Cell. Neurosci. 46, 235-244. doi: 10.1016/j.mcn.2010.09.006
    • (2011) Mol. Cell. Neurosci. , vol.46 , pp. 235-244
    • Perdigoto, A.L.1    Chaudhry, N.2    Barnes, G.N.3    Filbin, M.T.4    Carter, B.D.5
  • 110
    • 84890465438 scopus 로고    scopus 로고
    • Cowden syndrome and the PTEN hamartoma tumor syndrome: Systematic review and revised diagnostic criteria
    • doi: 10.1093/jnci/djt277
    • Pilarski, R., Burt, R., Kohlman, W., Pho, L., Shannon, K. M., and Swisher, E. (2013). Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria. J. Natl. Cancer Inst. 105, 1607-1616. doi: 10.1093/jnci/djt277
    • (2013) J. Natl. Cancer Inst. , vol.105 , pp. 1607-1616
    • Pilarski, R.1    Burt, R.2    Kohlman, W.3    Pho, L.4    Shannon, K.M.5    Swisher, E.6
  • 111
    • 40549118822 scopus 로고    scopus 로고
    • The nuclear affairs of PTEN
    • doi: 10.1242/jcs.022459
    • Planchon, S. M., Waite, K. A., and Eng, C. (2008). The nuclear affairs of PTEN. J. Cell Sci. 121, 249-253. doi: 10.1242/jcs.022459
    • (2008) J. Cell Sci. , vol.121 , pp. 249-253
    • Planchon, S.M.1    Waite, K.A.2    Eng, C.3
  • 112
    • 84866857904 scopus 로고    scopus 로고
    • The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells
    • doi: 10.1126/scisignal.2003084
    • Putz, U., Howitt, J., Doan, A., Goh, C.-P., Low, L.-H., Silke, J., et al. (2012). The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells. Sci. Signal. 5:ra70. doi: 10.1126/scisignal.2003084
    • (2012) Sci. Signal. , vol.5
    • Putz, U.1    Howitt, J.2    Doan, A.3    Goh, C.-P.4    Low, L.-H.5    Silke, J.6
  • 113
    • 1242284600 scopus 로고    scopus 로고
    • Regulation of cell migration by the C2 domain of the tumor suppressor PTEN
    • doi: 10.1126/science.1092089
    • Raftopoulou, M., Etienne-Manneville, S., Self, A., Nicholls, S., and Hall, A. (2004). Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. Science 303, 1179-1181. doi: 10.1126/science.1092089
    • (2004) Science , vol.303 , pp. 1179-1181
    • Raftopoulou, M.1    Etienne-Manneville, S.2    Self, A.3    Nicholls, S.4    Hall, A.5
  • 114
    • 58849102128 scopus 로고    scopus 로고
    • A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN
    • doi: 10.1073/pnas.0811212106
    • Rahdar, M., Inoue, T., Meyer, T., Zhang, J., Vazquez, F., and Devreotes, P. N. (2009). A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc. Natl. Acad. Sci. U.S.A. 106, 480-485. doi: 10.1073/pnas.0811212106
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 480-485
    • Rahdar, M.1    Inoue, T.2    Meyer, T.3    Zhang, J.4    Vazquez, F.5    Devreotes, P.N.6
  • 115
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: Exosomes, microvesicles, and friends
    • doi: 10.1083/jcb.201211138
    • Raposo, G., and Stoorvogel, W. (2013). Extracellular vesicles: exosomes, microvesicles, and friends. J. Cell Biol. 200, 373-383. doi: 10.1083/jcb.201211138
    • (2013) J. Cell Biol. , vol.200 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 116
  • 117
    • 39649095159 scopus 로고    scopus 로고
    • PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes
    • doi: 10.1021/bi702114w
    • Redfern, R. E., Redfern, D., Furgason, M. L., Munson, M., Ross, A. H., and Gericke, A. (2008). PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes. Biochemistry (Mosc.) 47, 2162-2171. doi: 10.1021/bi702114w
    • (2008) Biochemistry (Mosc.) , vol.47 , pp. 2162-2171
    • Redfern, R.E.1    Redfern, D.2    Furgason, M.L.3    Munson, M.4    Ross, A.H.5    Gericke, A.6
  • 118
    • 33845507061 scopus 로고    scopus 로고
    • Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease
    • doi: 10.1073/pnas.0606401103
    • Ries, V., Henchcliffe, C., Kareva, T., Rzhetskaya, M., Bland, R., During, M. J., et al. (2006). Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease. Proc. Natl. Acad. Sci. U.S.A. 103, 18757-18762. doi: 10.1073/pnas.0606401103
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 18757-18762
    • Ries, V.1    Henchcliffe, C.2    Kareva, T.3    Rzhetskaya, M.4    Bland, R.5    During, M.J.6
  • 119
    • 80053984176 scopus 로고    scopus 로고
    • A comprehensive functional analysis of PTEN mutations: Implications in tumor-and autism-related syndromes
    • doi: 10.1093/hmg/ddr337
    • Rodríguez-Escudero, I., Oliver, M. D., Andrés-Pons, A., Molina, M., Cid, V. J., and Pulido, R. (2011). A comprehensive functional analysis of PTEN mutations: implications in tumor-and autism-related syndromes. Hum. Mol. Genet. 20, 4132-4142. doi: 10.1093/hmg/ddr337
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 4132-4142
    • Rodríguez-Escudero, I.1    Oliver, M.D.2    Andrés-Pons, A.3    Molina, M.4    Cid, V.J.5    Pulido, R.6
  • 120
    • 60849132775 scopus 로고    scopus 로고
    • Phosphorylation keeps PTEN phosphatase closed for business
    • doi: 10.1073/pnas.0812473106
    • Ross, A. H., and Gericke, A. (2009). Phosphorylation keeps PTEN phosphatase closed for business. Proc. Natl. Acad. Sci. U.S.A. 106, 1297-1298. doi: 10.1073/pnas.0812473106
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 1297-1298
    • Ross, A.H.1    Gericke, A.2
  • 121
    • 15444373513 scopus 로고    scopus 로고
    • PTEN as an effector in the signaling of antimigratory G protein-coupled receptor
    • doi: 10.1073/pnas.0409784102
    • Sanchez, T., Thangada, S., Wu, M. T., Kontos, C. D., Wu, D., Wu, H., et al. (2005). PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc. Natl. Acad. Sci. U.S.A. 102, 4312-4317. doi: 10.1073/pnas.0409784102
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 4312-4317
    • Sanchez, T.1    Thangada, S.2    Wu, M.T.3    Kontos, C.D.4    Wu, D.5    Wu, H.6
  • 122
    • 33845999615 scopus 로고    scopus 로고
    • Essential role for nuclear PTEN in maintaining chromosomal integrity
    • doi: 10.1016/j.cell.2006.11.042
    • Shen, W. H., Balajee, A. S., Wang, J., Wu, H., Eng, C., Pandolfi, P. P., et al. (2007). Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128, 157-170. doi: 10.1016/j.cell.2006.11.042
    • (2007) Cell , vol.128 , pp. 157-170
    • Shen, W.H.1    Balajee, A.S.2    Wang, J.3    Wu, H.4    Eng, C.5    Pandolfi, P.P.6
  • 123
    • 84859593968 scopus 로고    scopus 로고
    • Membrane association of the PTEN tumor suppressor: Molecular details of the protein-membrane complex from SPR binding studies and neutron reflection
    • doi: 10.1371/journal.pone.0032591
    • Shenoy, S., Shekhar, P., Heinrich, F., Daou, M. C., Gericke, A., Ross, A. H., et al. (2012). Membrane association of the PTEN tumor suppressor: molecular details of the protein-membrane complex from SPR binding studies and neutron reflection. PLoS ONE 7:e32591. doi: 10.1371/journal.pone.0032591
    • (2012) PLoS ONE , vol.7
    • Shenoy, S.1    Shekhar, P.2    Heinrich, F.3    Daou, M.C.4    Gericke, A.5    Ross, A.H.6
  • 124
    • 84863874680 scopus 로고    scopus 로고
    • Phosphoinositides in cell architecture
    • doi: 10.1101/cshperspect.a004796
    • Shewan, A., Eastburn, D. J., and Mostov, K. (2011). Phosphoinositides in cell architecture. Cold Spring Harb. Perspect. Biol. 3:a004796. doi: 10.1101/cshperspect.a004796
    • (2011) Cold Spring Harb. Perspect. Biol. , vol.3
    • Shewan, A.1    Eastburn, D.J.2    Mostov, K.3
  • 125
    • 84872170622 scopus 로고    scopus 로고
    • PTEN at a glance
    • doi: 10.1242/jcs.093765
    • Shi, Y., Paluch, B. E., Wang, X., and Jiang, X. (2012). PTEN at a glance. J. Cell Sci. 125, 4687-4692. doi: 10.1242/jcs.093765
    • (2012) J. Cell Sci. , vol.125 , pp. 4687-4692
    • Shi, Y.1    Paluch, B.E.2    Wang, X.3    Jiang, X.4
  • 126
    • 78651482046 scopus 로고    scopus 로고
    • Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner
    • doi: 10.1016/j.cell.2010.12.020
    • Song, M. S., Carracedo, A., Salmena, L., Song, S. J., Egia, A., Malumbres, M., et al. (2011). Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell 144, 187-199. doi: 10.1016/j.cell.2010.12.020
    • (2011) Cell , vol.144 , pp. 187-199
    • Song, M.S.1    Carracedo, A.2    Salmena, L.3    Song, S.J.4    Egia, A.5    Malumbres, M.6
  • 127
    • 53649106156 scopus 로고    scopus 로고
    • The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network
    • doi: 10.1038/nature07290
    • Song, M. S., Salmena, L., Carracedo, A., Egia, A., Lo-Coco, F., Teruya-Feldstein, J., et al. (2008). The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. Nature 455, 813-817. doi: 10.1038/nature07290
    • (2008) Nature , vol.455 , pp. 813-817
    • Song, M.S.1    Salmena, L.2    Carracedo, A.3    Egia, A.4    Lo-Coco, F.5    Teruya-Feldstein, J.6
  • 128
    • 84860217431 scopus 로고    scopus 로고
    • The functions and regulation of the PTEN tumour suppressor
    • doi: 10.1038/nrm3330
    • Song, M. S., Salmena, L., and Pandolfi, P. P. (2012). The functions and regulation of the PTEN tumour suppressor. Nat. Rev. Mol. Cell Biol. 13, 283-296. doi: 10.1038/nrm3330
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 283-296
    • Song, M.S.1    Salmena, L.2    Pandolfi, P.P.3
  • 129
    • 75749112450 scopus 로고    scopus 로고
    • Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles
    • doi: 10.1016/j.neulet.2009.12.078
    • Sonoda, Y., Mukai, H., Matsuo, K., Takahashi, M., Ono, Y., Maeda, K., et al. (2010). Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles. Neurosci. Lett. 471, 20-24. doi: 10.1016/j.neulet.2009.12.078
    • (2010) Neurosci. Lett. , vol.471 , pp. 20-24
    • Sonoda, Y.1    Mukai, H.2    Matsuo, K.3    Takahashi, M.4    Ono, Y.5    Maeda, K.6
  • 130
    • 84856904410 scopus 로고    scopus 로고
    • Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration
    • doi: 10.1113/jphysiol.2011.220236
    • Sperow, M., Berry, R. B., Bayazitov, I. T., Zhu, G., Baker, S. J., and Zakharenko, S. S. (2012). Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration. J. Physiol. 590, 777-792. doi: 10.1113/jphysiol.2011.220236
    • (2012) J. Physiol. , vol.590 , pp. 777-792
    • Sperow, M.1    Berry, R.B.2    Bayazitov, I.T.3    Zhu, G.4    Baker, S.J.5    Zakharenko, S.S.6
  • 131
    • 79961192077 scopus 로고    scopus 로고
    • The actin nucleating Arp2/3 complex contributes to the formation of axonal filopodia and branches through the regulation of actin patch precursors to filopodia
    • doi: 10.1002/dneu.20907
    • Spillane, M., Ketschek, A., Jones, S. L., Korobova, F., Marsick, B., Lanier, L., et al. (2011). The actin nucleating Arp2/3 complex contributes to the formation of axonal filopodia and branches through the regulation of actin patch precursors to filopodia. Dev. Neurobiol. 71, 747-758. doi: 10.1002/dneu.20907
    • (2011) Dev. Neurobiol. , vol.71 , pp. 747-758
    • Spillane, M.1    Ketschek, A.2    Jones, S.L.3    Korobova, F.4    Marsick, B.5    Lanier, L.6
  • 132
    • 1642512636 scopus 로고    scopus 로고
    • Synergy in tumor suppression by direct interaction of neutral endopeptidase with PTEN
    • doi: 10.1016/S1535-6108(03)00331-3
    • Sumitomo, M., Iwase, A., Zheng, R., Navarro, D., Kaminetzky, D., Shen, R., et al. (2004). Synergy in tumor suppression by direct interaction of neutral endopeptidase with PTEN. Cancer Cell 5, 67-78. doi: 10.1016/S1535-6108(03)00331-3
    • (2004) Cancer Cell , vol.5 , pp. 67-78
    • Sumitomo, M.1    Iwase, A.2    Zheng, R.3    Navarro, D.4    Kaminetzky, D.5    Shen, R.6
  • 133
    • 83555174832 scopus 로고    scopus 로고
    • Sustained axon regeneration induced by co-deletion of PTEN and SOCS3
    • doi: 10.1038/nature10594
    • Sun, F., Park, K. K., Belin, S., Wang, D., Lu, T., Chen, G., et al. (2011). Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature 480, 372-375. doi: 10.1038/nature10594
    • (2011) Nature , vol.480 , pp. 372-375
    • Sun, F.1    Park, K.K.2    Belin, S.3    Wang, D.4    Lu, T.5    Chen, G.6
  • 134
    • 84875270373 scopus 로고    scopus 로고
    • Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism
    • doi: 10.1073/pnas.1222803110
    • Takeuchi, K., Gertner, M. J., Zhou, J., Parada, L. F., Bennett, M. V. L., and Zukin, R. S. (2013). Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism. Proc. Natl. Acad. Sci. U.S.A. 110, 4738-4743. doi: 10.1073/pnas.1222803110
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 4738-4743
    • Takeuchi, K.1    Gertner, M.J.2    Zhou, J.3    Parada, L.F.4    Bennett, M.V.L.5    Zukin, R.S.6
  • 135
    • 0033575287 scopus 로고    scopus 로고
    • PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway
    • doi: 10.1074/jbc.274.29.20693
    • Tamura, M., Gu, J., Danen, E. H., Takino, T., Miyamoto, S., and Yamada, K. M. (1999). PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J. Biol. Chem. 274, 20693-20703. doi: 10.1074/jbc.274.29.20693
    • (1999) J. Biol. Chem. , vol.274 , pp. 20693-20703
    • Tamura, M.1    Gu, J.2    Danen, E.H.3    Takino, T.4    Miyamoto, S.5    Yamada, K.M.6
  • 136
    • 0032486198 scopus 로고    scopus 로고
    • Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
    • doi: 10.1126/science.280.5369.1614
    • Tamura, M., Gu, J., Matsumoto, K., Aota, S., Parsons, R., and Yamada, K. M. (1998). Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280, 1614-1617. doi: 10.1126/science.280.5369.1614
    • (1998) Science , vol.280 , pp. 1614-1617
    • Tamura, M.1    Gu, J.2    Matsumoto, K.3    Aota, S.4    Parsons, R.5    Yamada, K.M.6
  • 137
    • 84865189134 scopus 로고    scopus 로고
    • Interference with the PTEN-MAST2 interaction by a viral protein leads to cellular relocalization of PTEN
    • doi: 10.1126/scisignal.2002941
    • Terrien, E., Chaffotte, A., Lafage, M., Khan, Z., Préhaud, C., Cordier, F., et al. (2012). Interference with the PTEN-MAST2 interaction by a viral protein leads to cellular relocalization of PTEN. Sci. Signal. 5:ra58. doi: 10.1126/scisignal.2002941
    • (2012) Sci. Signal. , vol.5
    • Terrien, E.1    Chaffotte, A.2    Lafage, M.3    Khan, Z.4    Préhaud, C.5    Cordier, F.6
  • 138
    • 84857718063 scopus 로고    scopus 로고
    • PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity
    • doi: 10.1126/scisignal.2002138
    • Tibarewal, P., Zilidis, G., Spinelli, L., Schurch, N., Maccario, H., Gray, A., et al. (2012). PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity. Sci. Signal. 5, ra18. doi: 10.1126/scisignal.2002138
    • (2012) Sci. Signal. , vol.5
    • Tibarewal, P.1    Zilidis, G.2    Spinelli, L.3    Schurch, N.4    McCario, H.5    Gray, A.6
  • 139
    • 33845977965 scopus 로고    scopus 로고
    • Ubiquitination regulates PTEN nuclear import and tumor suppression
    • doi: 10.1016/j.cell.2006.11.040
    • Trotman, L. C., Wang, X., Alimonti, A., Chen, Z., Teruya-Feldstein, J., Yang, H., et al. (2007). Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 128, 141-156. doi: 10.1016/j.cell.2006.11.040
    • (2007) Cell , vol.128 , pp. 141-156
    • Trotman, L.C.1    Wang, X.2    Alimonti, A.3    Chen, Z.4    Teruya-Feldstein, J.5    Yang, H.6
  • 140
    • 84880469585 scopus 로고    scopus 로고
    • PIP3 regulates spinule formation in dendritic spines during structural long-term potentiation
    • doi: 10.1523/JNEUROSCI.3122-12.2013
    • Ueda, Y., and Hayashi, Y. (2013). PIP3 regulates spinule formation in dendritic spines during structural long-term potentiation. J. Neurosci. 33, 11040-11047. doi: 10.1523/JNEUROSCI.3122-12.2013
    • (2013) J. Neurosci. , vol.33 , pp. 11040-11047
    • Ueda, Y.1    Hayashi, Y.2
  • 141
    • 37149046442 scopus 로고    scopus 로고
    • Function of PTEN during the formation and maintenance of neuronal circuits in the brain
    • doi: 10.1159/000109852
    • Van Diepen, M. T., and Eickholt, B. J. (2008). Function of PTEN during the formation and maintenance of neuronal circuits in the brain. Dev. Neurosci. 30, 59-64. doi: 10.1159/000109852
    • (2008) Dev. Neurosci. , vol.30 , pp. 59-64
    • Van Diepen, M.T.1    Eickholt, B.J.2
  • 144
    • 84857406235 scopus 로고    scopus 로고
    • PI3K signalling: The path to discovery and understanding
    • doi: 10.1038/nrm3290
    • Vanhaesebroeck, B., Stephens, L., and Hawkins, P. (2012). PI3K signalling: the path to discovery and understanding. Nat. Rev. Mol. Cell Biol. 13, 195-203. doi: 10.1038/nrm3290
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 195-203
    • Vanhaesebroeck, B.1    Stephens, L.2    Hawkins, P.3
  • 145
    • 62149104335 scopus 로고    scopus 로고
    • The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly
    • doi: 10.1097/GIM.0b013e31818fd762
    • Varga, E. A., Pastore, M., Prior, T., Herman, G. E., and McBride, K. L. (2009). The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly. Genet. Med. 11, 111-117. doi: 10.1097/GIM.0b013e31818fd762
    • (2009) Genet. Med. , vol.11 , pp. 111-117
    • Varga, E.A.1    Pastore, M.2    Prior, T.3    Herman, G.E.4    McBride, K.L.5
  • 146
    • 33746225428 scopus 로고    scopus 로고
    • Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction
    • doi: 10.4161/cc.5.14.3005
    • Vazquez, F., and Devreotes, P. (2006). Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction. Cell Cycle 5, 1523-1527. doi: 10.4161/cc.5.14.3005
    • (2006) Cell Cycle , vol.5 , pp. 1523-1527
    • Vazquez, F.1    Devreotes, P.2
  • 147
    • 0035966127 scopus 로고    scopus 로고
    • Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex
    • doi: 10.1074/jbc.C100556200
    • Vazquez, F., Grossman, S. R., Takahashi, Y., Rokas, M. V., Nakamura, N., and Sellers, W. R. (2001). Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J. Biol. Chem. 276, 48627-48630. doi: 10.1074/jbc.C100556200
    • (2001) J. Biol. Chem. , vol.276 , pp. 48627-48630
    • Vazquez, F.1    Grossman, S.R.2    Takahashi, Y.3    Rokas, M.V.4    Nakamura, N.5    Sellers, W.R.6
  • 148
    • 33644870152 scopus 로고    scopus 로고
    • Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane
    • doi: 10.1073/pnas.0510570103
    • Vazquez, F., Matsuoka, S., Sellers, W. R., Yanagida, T., Ueda, M., and Devreotes, P. N. (2006). Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. Proc. Natl. Acad. Sci. U.S.A. 103, 3633-3638. doi: 10.1073/pnas.0510570103
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 3633-3638
    • Vazquez, F.1    Matsuoka, S.2    Sellers, W.R.3    Yanagida, T.4    Ueda, M.5    Devreotes, P.N.6
  • 149
    • 17744386543 scopus 로고    scopus 로고
    • Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling
    • doi: 10.1242/dev.01720
    • Von Stein, W., Ramrath, A., Grimm, A., Muller-Borg, M., and Wodarz, A. (2005). Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling. Development 132, 1675-1686. doi: 10.1242/dev.01720
    • (2005) Development , vol.132 , pp. 1675-1686
    • Von Stein, W.1    Ramrath, A.2    Grimm, A.3    Muller-Borg, M.4    Wodarz, A.5
  • 150
    • 79952114000 scopus 로고    scopus 로고
    • The neurodevelopmental implications of PI3K signaling
    • doi: 10.1007/82_2010_82
    • Waite, K., and Eickholt, B. J. (2010). The neurodevelopmental implications of PI3K signaling. Curr. Top. Microbiol. Immunol. 346, 245-265. doi: 10.1007/82_2010_82
    • (2010) Curr. Top. Microbiol. Immunol. , vol.346 , pp. 245-265
    • Waite, K.1    Eickholt, B.J.2
  • 151
    • 84855588783 scopus 로고    scopus 로고
    • Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury
    • doi: 10.1371/journal.pone.0030012
    • Walker, C. L., Walker, M. J., Liu, N.-K., Risberg, E. C., Gao, X., Chen, J., et al. (2012). Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury. PloS ONE 7:e30012. doi: 10.1371/journal.pone.0030012
    • (2012) PloS ONE , vol.7
    • Walker, C.L.1    Walker, M.J.2    Liu, N.-K.3    Risberg, E.C.4    Gao, X.5    Chen, J.6
  • 152
    • 2342631914 scopus 로고    scopus 로고
    • The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif
    • doi: 10.1042/BJ20031839
    • Walker, S. M., Leslie, N. R., Perera, N. M., Batty, I. H., and Downes, C. P. (2004). The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif. Biochem. J. 379, 301-307. doi: 10.1042/BJ20031839
    • (2004) Biochem. J. , vol.379 , pp. 301-307
    • Walker, S.M.1    Leslie, N.R.2    Perera, N.M.3    Batty, I.H.4    Downes, C.P.5
  • 153
    • 0037124108 scopus 로고    scopus 로고
    • Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection
    • doi: 10.1074/jbc.M111704200
    • Wei, W., Wang, X., and Kusiak, J. W. (2002). Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection. J. Biol. Chem. 277, 17649-17656. doi: 10.1074/jbc.M111704200
    • (2002) J. Biol. Chem. , vol.277 , pp. 17649-17656
    • Wei, W.1    Wang, X.2    Kusiak, J.W.3
  • 154
    • 0037155727 scopus 로고    scopus 로고
    • P-Rex1, a PtdIns(3,4,5)P3-and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac
    • doi: 10.1016/S0092-8674(02)00663-3
    • Welch, H. C. E., Coadwell, W. J., Ellson, C. D., Ferguson, G. J., Andrews, S. R., Erdjument-Bromage, H., et al. (2002). P-Rex1, a PtdIns(3,4,5)P3-and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell 108, 809-821. doi: 10.1016/S0092-8674(02)00663-3
    • (2002) Cell , vol.108 , pp. 809-821
    • Welch, H.C.E.1    Coadwell, W.J.2    Ellson, C.D.3    Ferguson, G.J.4    Andrews, S.R.5    Erdjument-Bromage, H.6
  • 155
    • 84880642453 scopus 로고    scopus 로고
    • Autism spectrum disorder causes, mechanisms, and treatments: Focus on neuronal synapses
    • doi: 10.3389/fnmol.2013.00019
    • Won, H., Mah, W., and Kim, E. (2013). Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses. Front. Mol. Neurosci. 6:19. doi: 10.3389/fnmol.2013.00019
    • (2013) Front. Mol. Neurosci. , vol.6 , pp. 19
    • Won, H.1    Mah, W.2    Kim, E.3
  • 156
    • 84884189701 scopus 로고    scopus 로고
    • Drebrin contains a cryptic F-actin-bundling activity regulated by Cdk5 phosphorylation
    • doi: 10.1083/jcb.201303005
    • Worth, D. C., Daly, C. N., Geraldo, S., Oozeer, F., and Gordon-Weeks, P. R. (2013). Drebrin contains a cryptic F-actin-bundling activity regulated by Cdk5 phosphorylation. J. Cell Biol. 202, 793-806. doi: 10.1083/jcb.201303005
    • (2013) J. Cell Biol. , vol.202 , pp. 793-806
    • Worth, D.C.1    Daly, C.N.2    Geraldo, S.3    Oozeer, F.4    Gordon-Weeks, P.R.5
  • 157
    • 36749070993 scopus 로고    scopus 로고
    • PDZ domains of Par-3 as potential phosphoinositide signaling integrators
    • doi: 10.1016/j.molcel.2007.10.028
    • Wu, H., Feng, W., Chen, J., Chan, L. N., Huang, S., and Zhang, M. (2007). PDZ domains of Par-3 as potential phosphoinositide signaling integrators. Mol. Cell 28, 886-898. doi: 10.1016/j.molcel.2007.10.028
    • (2007) Mol. Cell , vol.28 , pp. 886-898
    • Wu, H.1    Feng, W.2    Chen, J.3    Chan, L.N.4    Huang, S.5    Zhang, M.6
  • 158
    • 0034636038 scopus 로고    scopus 로고
    • Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2
    • doi: 10.1073/pnas.97.8.4233
    • Wu, X., Hepner, K., Castelino-Prabhu, S., Do, D., Kaye, M. B., Yuan, X. J., et al. (2000). Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. Proc. Natl. Acad. Sci. U.S.A. 97, 4233-4238. doi: 10.1073/pnas.97.8.4233
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 4233-4238
    • Wu, X.1    Hepner, K.2    Castelino-Prabhu, S.3    Do, D.4    Kaye, M.B.5    Yuan, X.J.6
  • 159
    • 0038311944 scopus 로고    scopus 로고
    • Phosphoinositide regulation of the actin cytoskeleton
    • doi: 10.1146/annurev.physiol.65.092101.142517
    • Yin, H. L., and Janmey, P. A. (2003). Phosphoinositide regulation of the actin cytoskeleton. Annu. Rev. Physiol. 65, 761-789. doi: 10.1146/annurev.physiol.65.092101.142517
    • (2003) Annu. Rev. Physiol. , vol.65 , pp. 761-789
    • Yin, H.L.1    Janmey, P.A.2
  • 160
    • 84865209815 scopus 로고    scopus 로고
    • A phosphatidylinositol lipids system, lamellipodin, and Ena/VASP regulate dynamic morphology of multipolar migrating cells in the developing cerebral cortex
    • doi: 10.1523/JNEUROSCI.0738-12.2012
    • Yoshinaga, S., Ohkubo, T., Sasaki, S., Nuriya, M., Ogawa, Y., Yasui, M., et al. (2012). A phosphatidylinositol lipids system, lamellipodin, and Ena/VASP regulate dynamic morphology of multipolar migrating cells in the developing cerebral cortex. J. Neurosci. 32, 11643-11656. doi: 10.1523/JNEUROSCI.0738-12.2012
    • (2012) J. Neurosci. , vol.32 , pp. 11643-11656
    • Yoshinaga, S.1    Ohkubo, T.2    Sasaki, S.3    Nuriya, M.4    Ogawa, Y.5    Yasui, M.6
  • 161
    • 84877117383 scopus 로고    scopus 로고
    • Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries
    • doi: 10.1523/JNEUROSCI.5661-12.2013
    • Zhang, S., Taghibiglou, C., Girling, K., Dong, Z., Lin, S.-Z., Lee, W., et al. (2013). Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries. J. Neurosci. 33, 7997-8008. doi: 10.1523/JNEUROSCI.5661-12.2013
    • (2013) J. Neurosci. , vol.33 , pp. 7997-8008
    • Zhang, S.1    Taghibiglou, C.2    Girling, K.3    Dong, Z.4    Lin, S.-Z.5    Lee, W.6
  • 162
    • 33845619414 scopus 로고    scopus 로고
    • Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules
    • doi: 10.1096/fj.06-5721fje
    • Zhang, X., Li, F., Bulloj, A., Zhang, Y.-W., Tong, G., Zhang, Z., et al. (2006). Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules. FASEB J. 20, 1272-1274. doi: 10.1096/fj.06-5721fje
    • (2006) FASEB J. , vol.20 , pp. 1272-1274
    • Zhang, X.1    Li, F.2    Bulloj, A.3    Zhang, Y.-W.4    Tong, G.5    Zhang, Z.6
  • 163
    • 84862208776 scopus 로고    scopus 로고
    • Functional analysis of the protein phosphatase activity of PTEN
    • doi: 10.1042/BJ20120098
    • Zhang, X. C., Piccini, A., Myers, M. P., Van Aelst, L., and Tonks, N. K. (2012a). Functional analysis of the protein phosphatase activity of PTEN. Biochem. J. 444, 457-464. doi: 10.1042/BJ20120098
    • (2012) Biochem. J. , vol.444 , pp. 457-464
    • Zhang, X.C.1    Piccini, A.2    Myers, M.P.3    Van Aelst, L.4    Tonks, N.K.5
  • 164
    • 84866393562 scopus 로고    scopus 로고
    • PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice
    • doi: 10.1093/brain/aws196
    • Zhang, Y., Granholm, A.-C., Huh, K., Shan, L., Diaz-Ruiz, O., Malik, N., et al. (2012b). PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice. Brain 135, 2736-2749. doi: 10.1093/brain/aws196
    • (2012) Brain , vol.135 , pp. 2736-2749
    • Zhang, Y.1    Granholm, A.-C.2    Huh, K.3    Shan, L.4    Diaz-Ruiz, O.5    Malik, N.6
  • 165
    • 60849109211 scopus 로고    scopus 로고
    • Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice
    • doi: 10.1523/JNEUROSCI.5685-08.2009
    • Zhou, J., Blundell, J., Ogawa, S., Kwon, C.-H., Zhang, W., Sinton, C., et al. (2009). Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J. Neurosci. 29, 1773-1783. doi: 10.1523/JNEUROSCI.5685-08.2009
    • (2009) J. Neurosci. , vol.29 , pp. 1773-1783
    • Zhou, J.1    Blundell, J.2    Ogawa, S.3    Kwon, C.-H.4    Zhang, W.5    Sinton, C.6
  • 166
    • 84868198811 scopus 로고    scopus 로고
    • PTEN signaling in autism spectrum disorders
    • doi: 10.1016/j.conb.2012.05.004
    • Zhou, J., and Parada, L. F. (2012). PTEN signaling in autism spectrum disorders. Curr. Opin. Neurobiol. 22, 873-879. doi: 10.1016/j.conb.2012.05.004
    • (2012) Curr. Opin. Neurobiol. , vol.22 , pp. 873-879
    • Zhou, J.1    Parada, L.F.2
  • 167
    • 33344476774 scopus 로고    scopus 로고
    • PTEN: A crucial mediator of mitochondria-dependent apoptosis
    • doi: 10.1007/s10495-006-3714-5
    • Zhu, Y., Hoell, P., Ahlemeyer, B., and Krieglstein, J. (2006). PTEN: a crucial mediator of mitochondria-dependent apoptosis. Apoptosis 11, 197-207. doi: 10.1007/s10495-006-3714-5
    • (2006) Apoptosis , vol.11 , pp. 197-207
    • Zhu, Y.1    Hoell, P.2    Ahlemeyer, B.3    Krieglstein, J.4
  • 168
    • 33846626477 scopus 로고    scopus 로고
    • Implication of PTEN in production of reactive oxygen species and neuronal death in in vitro models of stroke and Parkinson's disease
    • doi: 10.1016/j.neuint.2006.10.010
    • Zhu, Y., Hoell, P., Ahlemeyer, B., Sure, U., Bertalanffy, H., and Krieglstein, J. (2007). Implication of PTEN in production of reactive oxygen species and neuronal death in in vitro models of stroke and Parkinson's disease. Neurochem. Int. 50, 507-516. doi: 10.1016/j.neuint.2006.10.010
    • (2007) Neurochem. Int. , vol.50 , pp. 507-516
    • Zhu, Y.1    Hoell, P.2    Ahlemeyer, B.3    Sure, U.4    Bertalanffy, H.5    Krieglstein, J.6
  • 169
    • 79958073565 scopus 로고    scopus 로고
    • Ischemic preconditioning attenuates mitochondrial localization of PTEN induced by ischemia-reperfusion
    • doi: 10.1152/ajpheart.01138.2010
    • Zu, L., Zheng, X., Wang, B., Parajuli, N., Steenbergen, C., Becker, L. C., et al. (2011). Ischemic preconditioning attenuates mitochondrial localization of PTEN induced by ischemia-reperfusion. Am. J. Physiol. Heart Circ. Physiol. 300, H2177-H2186. doi: 10.1152/ajpheart.01138.2010
    • (2011) Am. J. Physiol. Heart Circ. Physiol. , vol.300
    • Zu, L.1    Zheng, X.2    Wang, B.3    Parajuli, N.4    Steenbergen, C.5    Becker, L.C.6
  • 170
    • 84884545941 scopus 로고    scopus 로고
    • Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury
    • doi: 10.1523/JNEUROSCI.2510-13.2013
    • Zukor, K., Belin, S., Wang, C., Keelan, N., Wang, X., and He, Z. (2013). Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury. J. Neurosci. 33, 15350-15361. doi: 10.1523/JNEUROSCI.2510-13.2013
    • (2013) J. Neurosci. , vol.33 , pp. 15350-15361
    • Zukor, K.1    Belin, S.2    Wang, C.3    Keelan, N.4    Wang, X.5    He, Z.6


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