Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN

Science

Volumn 303, Issue 5661, 2004, Pages 1179-1181

  Raftopoulou, Myrto ^a   Etienne Manneville, Sandrine ^a   Self, Annette ^a   Nicholls, Sarah ^a   Hall, Alan ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYMES; LIPIDS; TUMORS;

CELL SIGNALLING; TUMOR SUPRESSORS;

CELLS;

LIPID; LIPID PHOSPHATASE; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOTHREONINE; RECOMBINANT PROTEIN; THREONINE; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

TUMOR;

ANIMAL; ARTICLE; CANCER INHIBITION; CATALYSIS; CELL MIGRATION; CELL MOTION; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; DEPHOSPHORYLATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; GENE DELETION; GENETIC TRANSFECTION; GENETICS; GLIOMA; HUMAN; HUMAN CELL; METABOLISM; MUTATION; PHOSPHORYLATION; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TERTIARY STRUCTURE; SERODIAGNOSIS; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ANIMALS; CATALYSIS; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL MOVEMENT; CERCOPITHECUS AETHIOPS; COS CELLS; GLIOMA; HUMANS; MUTATION; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PHOSPHOTHREONINE; PRECIPITIN TESTS; PROTEIN STRUCTURE, TERTIARY; PTEN PHOSPHOHYDROLASE; RECOMBINANT PROTEINS; SEQUENCE DELETION; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; CERCOPITHECUS;

EID: 1242284600     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1092089     Document Type: Article

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26. We thank N. K. Tonks for PTEN constructs, D. F. Cutler for synaptotagmin constructs, and A. Schmidt and A. B. Jaffe for helpful discussions. Supported by the Cancer Research UK and the Medical Research Council. M.R. is supported by a Medical Research Council Ph.D. studentship.