메뉴 건너뛰기




Volumn 30, Issue 13, 2011, Pages 2557-2568

Distinct functional outputs of PTEN signalling are controlled by dynamic association with β 2-arrestins

Author keywords

arrestin; Akt; cell migration; cell proliferation; PTEN

Indexed keywords

BETA ARRESTIN; PHOSPHATIDATE PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; REGULATOR PROTEIN; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SCAFFOLD PROTEIN;

EID: 79960038559     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2011.178     Document Type: Article
Times cited : (64)

References (52)
  • 1
    • 79952265050 scopus 로고    scopus 로고
    • Beta-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation
    • Anthony DF, Sin YY, Vadrevu S, Advant N, Day JP, Byrne AM, Lynch MJ, Milligan G, Houslay MD, Baillie GS (2011) beta-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation. Mol Cell Biol 31: 1066-1075
    • (2011) Mol Cell Biol , vol.31 , pp. 1066-1075
    • Anthony, D.F.1    Sin, Y.Y.2    Vadrevu, S.3    Advant, N.4    Day, J.P.5    Byrne, A.M.6    Lynch, M.J.7    Milligan, G.8    Houslay, M.D.9    Baillie, G.S.10
  • 2
    • 0030923133 scopus 로고    scopus 로고
    • Isolation of an AP-1 repressor by a novel method for detecting protein- protein interactions
    • Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M (1997) Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Mol Cell Biol 17: 3094-3102 (Pubitemid 27215024)
    • (1997) Molecular and Cellular Biology , vol.17 , Issue.6 , pp. 3094-3102
    • Aronheim, A.1    Zandi, E.2    Hennemann, H.3    Elledge, S.J.4    Karin, M.5
  • 3
    • 14844338481 scopus 로고    scopus 로고
    • αq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation
    • DOI 10.1074/jbc.M412924200
    • Barnes WG, Reiter E, Violin JD, Ren XR, Milligan G, Lefkowitz RJ (2005) beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J Biol Chem 280: 8041-8050 (Pubitemid 40349702)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.9 , pp. 8041-8050
    • Barnes, W.G.1    Reiter, E.2    Violin, J.D.3    Ren, X.-R.4    Milligan, G.5    Lefkowitz, R.J.6
  • 4
    • 22744449073 scopus 로고    scopus 로고
    • An Akt/β-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    • DOI 10.1016/j.cell.2005.05.012, PII S0092867405004575
    • Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG (2005) An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 122: 261-273 (Pubitemid 41032989)
    • (2005) Cell , vol.122 , Issue.2 , pp. 261-273
    • Beaulieu, J.-M.1    Sotnikova, T.D.2    Marion, S.3    Lefkowitz, R.J.4    Gainetdinov, R.R.5    Caron, M.G.6
  • 7
    • 66149141021 scopus 로고    scopus 로고
    • PTEN and the PI3-kinase pathway in cancer
    • Chalhoub N, Baker SJ (2009) PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol 4: 127-150
    • (2009) Annu Rev Pathol , vol.4 , pp. 127-150
    • Chalhoub, N.1    Baker, S.J.2
  • 10
    • 33947424807 scopus 로고    scopus 로고
    • Stop that cell! Beta-arrestin-dependent chemo-taxis: A tale of localized actin assembly and receptor desensitiza-tion
    • DeFea KA (2007) Stop that cell! Beta-arrestin-dependent chemo-taxis: a tale of localized actin assembly and receptor desensitiza-tion. Annu Rev Physiol 69: 535-560
    • (2007) Annu Rev Physiol , vol.69 , pp. 535-560
    • Defea, K.A.1
  • 17
    • 2142851264 scopus 로고    scopus 로고
    • Lysophospholipid receptors: Signaling and biology
    • DOI 10.1146/annurev.biochem.73.011303.073731
    • Ishii I, Fukushima N, Ye X, Chun J (2004) Lysophospholipid receptors: signaling and biology. Annu Rev Biochem 73: 321-354 (Pubitemid 39050372)
    • (2004) Annual Review of Biochemistry , vol.73 , pp. 321-354
    • Ishii, I.1    Fukushima, N.2    Ye, X.3    Chun, J.4
  • 19
    • 0035945352 scopus 로고    scopus 로고
    • The lipid phosphatase activity of PTEN is critical for stabilizing intercellular junctions and reverting invasiveness
    • DOI 10.1083/jcb.200105109
    • Kotelevets L, van Hengel J, Bruyneel E, Mareel M, van Roy F, Chastre E (2001) The lipid phosphatase activity of PTEN is critical for stabilizing intercellular junctions and reverting invasiveness. J Cell Biol 155: 1129-1135 (Pubitemid 34286264)
    • (2001) Journal of Cell Biology , vol.155 , Issue.7 , pp. 1129-1135
    • Kotelevets, L.1    Van Hengel, J.2    Bruyneel, E.3    Mareel, M.4    Van Roy, F.5    Chastre, E.6
  • 20
    • 0033615538 scopus 로고    scopus 로고
    • Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
    • DOI 10.1016/S0092-8674(00)81663-3
    • Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, Pavletich NP (1999) Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 99: 323-334 (Pubitemid 29519911)
    • (1999) Cell , vol.99 , Issue.3 , pp. 323-334
    • Lee, J.-O.1    Yang, H.2    Georgescu, M.-M.3    Cristofano, A.D.4    Maehama, T.5    Shi, Y.6    Dixon, J.E.7    Pandolfi, P.8    Pavletich, N.P.9
  • 23
    • 77952415656 scopus 로고    scopus 로고
    • Beyond desensitization: Physiological relevance of arrestin-dependent signaling
    • Luttrell LM, Gesty-Palmer D (2010) Beyond desensitization: physiological relevance of arrestin-dependent signaling. Pharmacol Rev 62: 305-330
    • (2010) Pharmacol Rev , vol.62 , pp. 305-330
    • Luttrell, L.M.1    Gesty-Palmer, D.2
  • 24
    • 0032904432 scopus 로고    scopus 로고
    • PTEN: A tumour suppressor that functions as a phospholipid phosphatase
    • DOI 10.1016/S0962-8924(99)01519-6, PII S0962892499015196
    • Maehama T, Dixon JE (1999) PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol 9: 125-128 (Pubitemid 29161437)
    • (1999) Trends in Cell Biology , vol.9 , Issue.4 , pp. 125-128
    • Maehama, T.1    Dixon, J.E.2
  • 25
    • 0036710512 scopus 로고    scopus 로고
    • The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network
    • DOI 10.1016/S0968-0004(02)02166-7, PII S0968000402021667
    • Mayo LD, Donner DB (2002) The PTEN, Mdm2, p53 tumor sup-pressor- oncoprotein network. Trends Biochem Sci 27: 462-467 (Pubitemid 35246255)
    • (2002) Trends in Biochemical Sciences , vol.27 , Issue.9 , pp. 462-467
    • Mayo, L.D.1    Donner, D.B.2
  • 26
    • 82255163335 scopus 로고    scopus 로고
    • Differential expression of arrestins is a predictor of breast cancer progression and survival
    • (e-pub ahead of print 12 February 2011; doi:10.1007/s10549-011-1374-9)
    • Michal AM, Peck AR, Tran TH, Liu C, Rimm DL, Rui H, Benovic JL (2011) Differential expression of arrestins is a predictor of breast cancer progression and survival. Breast Cancer Res Treat (e-pub ahead of print 12 February 2011; doi:10.1007/s10549-011-1374-9)
    • (2011) Breast Cancer Res Treat
    • Michal, A.M.1    Peck, A.R.2    Tran, T.H.3    Liu, C.4    Rimm, D.L.5    Rui, H.6    Benovic, J.L.7
  • 28
    • 33947314576 scopus 로고    scopus 로고
    • Regulation of receptor trafficking by GRKs and arrestins
    • DOI 10.1146/annurev.physiol.69.022405.154712
    • Moore CA, Milano SK, Benovic JL (2007) Regulation of receptor trafficking by GRKs and arrestins. Annu Rev Physiol 69: 451-482 (Pubitemid 46457651)
    • (2007) Annual Review of Physiology , vol.69 , pp. 451-482
    • Moore, C.A.C.1    Milano, S.K.2    Benovic, J.L.3
  • 30
    • 34548154756 scopus 로고    scopus 로고
    • Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain
    • DOI 10.1074/jbc.M611240200
    • Odriozola L, Singh G, Hoang T, Chan AM (2007) Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain. J Biol Chem 282: 23306-23315 (Pubitemid 47311930)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.32 , pp. 23306-23315
    • Odriozola, L.1    Singh, G.2    Hoang, T.3    Chan, A.M.4
  • 31
    • 77952030607 scopus 로고    scopus 로고
    • Arrestin and the multi-PDZ domain-containing protein MPZ-1 interact with phosphatase and tensin homolog (PTEN) and regulate Caenorhabditis elegans longevity
    • Palmitessa A, Benovic JL (2010) Arrestin and the multi-PDZ domain-containing protein MPZ-1 interact with phosphatase and tensin homolog (PTEN) and regulate Caenorhabditis elegans longevity. J Biol Chem 285: 15187-15200
    • (2010) J Biol Chem , vol.285 , pp. 15187-15200
    • Palmitessa, A.1    Benovic, J.L.2
  • 32
    • 34447299716 scopus 로고    scopus 로고
    • The p110δ isoform of PI 3-kinase negatively controls RhoA and PTEN
    • DOI 10.1038/sj.emboj.7601763, PII 7601763
    • Papakonstanti EA, Ridley AJ, Vanhaesebroeck B (2007) The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN. EMBO J 26: 3050-3061 (Pubitemid 47057501)
    • (2007) EMBO Journal , vol.26 , Issue.13 , pp. 3050-3061
    • Papakonstanti, E.A.1    Ridley, A.J.2    Vanhaesebroeck, B.3
  • 33
    • 0347695992 scopus 로고    scopus 로고
    • β-Arrestin1 Mediates Insulin-like Growth Factor 1 (IGF-1) Activation of Phosphatidylinositol 3-Kinase (PI3K) and Anti-apoptosis
    • DOI 10.1074/jbc.M309968200
    • Povsic TJ, Kohout TA, Lefkowitz RJ (2003) Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidyli-nositol 3-kinase (PI3K) and anti-apoptosis. J Biol Chem 278: 51334-51339 (Pubitemid 38020372)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.51 , pp. 51334-51339
    • Povsic, T.J.1    Kohout, T.A.2    Lefkowitz, R.J.3
  • 34
    • 1242284600 scopus 로고    scopus 로고
    • Regulation of cell migration by the C2 domain of the tumor suppressor PTEN
    • DOI 10.1126/science.1092089
    • Raftopoulou M, Etienne-Manneville S, Self A, Nicholls S, Hall A (2004) Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. Science 303: 1179-1181 (Pubitemid 38233580)
    • (2004) Science , vol.303 , Issue.5661 , pp. 1179-1181
    • Raftopoulou, M.1    Etienne-Manneville, S.2    Self, A.3    Nicholls, S.4    Hall, A.5
  • 35
    • 58849102128 scopus 로고    scopus 로고
    • A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN
    • Rahdar M, Inoue T, Meyer T, Zhang J, Vazquez F, Devreotes PN (2009) A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci USA 106: 480-485
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 480-485
    • Rahdar, M.1    Inoue, T.2    Meyer, T.3    Zhang, J.4    Vazquez, F.5    Devreotes, P.N.6
  • 36
    • 43049128529 scopus 로고    scopus 로고
    • Tenets of PTEN Tumor Suppression
    • DOI 10.1016/j.cell.2008.04.013, PII S0092867408005047
    • Salmena L, Carracedo A, Pandolfi PP (2008) Tenets of PTEN tumor suppression. Cell 133: 403-414 (Pubitemid 351622014)
    • (2008) Cell , vol.133 , Issue.3 , pp. 403-414
    • Salmena, L.1    Carracedo, A.2    Pandolfi, P.P.3
  • 38
    • 0036479228 scopus 로고    scopus 로고
    • Recruitment of activated G protein-coupled receptors to pre-existing clathrin-coated pits in living cells
    • DOI 10.1074/jbc.M106586200
    • Scott MG, Benmerah A, Muntaner O, Marullo S (2002a) Recruitment of activated G protein-coupled receptors to pre-existing clathrin-coated Pits in living cells. J Biol Chem 277: 3552-3559 (Pubitemid 34953226)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.5 , pp. 3552-3559
    • Scott, M.G.H.1    Benmerah, A.2    Muntaner, O.3    Marullo, S.4
  • 39
    • 0037020264 scopus 로고    scopus 로고
    • Differential nucleocytoplasmic shuttling of beta-arrestins. Characterization of a leucine-rich nuclear export signal in beta-arrestin2
    • Scott MG, Le Rouzic E, Perianin A, Pierotti V, Enslen H, Benichou S, Marullo S, Benmerah A (2002b) Differential nucleocytoplasmic shuttling of beta-arrestins. Characterization of a leucine-rich nuclear export signal in beta-arrestin2. J Biol Chem 277: 37693-37701
    • (2002) J Biol Chem , vol.277 , pp. 37693-37701
    • Scott, M.G.1    Le Rouzic, E.2    Perianin, A.3    Pierotti, V.4    Enslen, H.5    Benichou, S.6    Marullo, S.7    Benmerah, A.8
  • 41
    • 69249208550 scopus 로고    scopus 로고
    • Regulation of RhoGEF proteins by G12/13-coupled receptors
    • Siehler S (2009) Regulation of RhoGEF proteins by G12/13-coupled receptors. Br J Pharmacol 158: 41-49
    • (2009) Br J Pharmacol , vol.158 , pp. 41-49
    • Siehler, S.1
  • 42
    • 67650539078 scopus 로고    scopus 로고
    • Thromboxane A2 receptor activates a Rho-associated kinase/ LKB1/PTEN pathway to attenuate endothelium insulin signaling
    • Song P, Zhang M, Wang S, Xu J, Choi HC, Zou MH (2009) Thromboxane A2 receptor activates a Rho-associated kinase/ LKB1/PTEN pathway to attenuate endothelium insulin signaling. J Biol Chem 284: 17120-17128
    • (2009) J Biol Chem , vol.284 , pp. 17120-17128
    • Song, P.1    Zhang, M.2    Wang, S.3    Xu, J.4    Choi, H.C.5    Zou, M.H.6
  • 43
    • 29244461715 scopus 로고    scopus 로고
    • 1 lysophosphatidic acid receptors
    • DOI 10.1242/jcs.02634
    • Urs NM, Jones KT, Salo PD, Severin JE, Trejo J, Radhakrishna H (2005) A requirement for membrane cholesterol in the beta-arrestin- and clathrin-dependent endocytosis of LPA1 lysophos-phatidic acid receptors. J Cell Sci 118: 5291-5304 (Pubitemid 41819591)
    • (2005) Journal of Cell Science , vol.118 , Issue.22 , pp. 5291-5304
    • Urs, N.M.1    Jones, K.T.2    Salo, P.D.3    Severin, J.E.4    Trejo, J.5    Radhakrishna, H.6
  • 44
    • 0033946740 scopus 로고    scopus 로고
    • Phosphorylation of the PTEN tail regulates protein stability and function
    • DOI 10.1128/MCB.20.14.5010-5018.2000
    • Vazquez F, Ramaswamy S, Nakamura N, Sellers WR (2000) Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol 20: 5010-5018 (Pubitemid 30431555)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.14 , pp. 5010-5018
    • Vazquez, F.1    Ramaswamy, S.2    Nakamura, N.3    Sellers, W.R.4
  • 47
    • 0037458705 scopus 로고    scopus 로고
    • β-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2
    • DOI 10.1074/jbc.M210350200
    • Wang P, Gao H, Ni Y, Wang B, Wu Y, Ji L, Qin L, Ma L, Pei G (2003a) Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2. J Biol Chem 278: 6363-6370 (Pubitemid 36800895)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.8 , pp. 6363-6370
    • Wang, P.1    Gao, H.2    Ni, Y.3    Wang, B.4    Wu, Y.5    Ji, L.6    Qin, L.7    Ma, L.8    Pei, G.9
  • 48
    • 36749006304 scopus 로고    scopus 로고
    • Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110α and β by protease-activated receptor 2 and β-arrestins
    • DOI 10.1042/BJ20070483
    • Wang P, Kumar P, Wang C, Defea KA (2007) Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110 alpha and beta by protease-activated receptor 2 and beta-arrest-ins. Biochem J 408: 221-230 (Pubitemid 350206345)
    • (2007) Biochemical Journal , vol.408 , Issue.2 , pp. 221-230
    • Wang, P.1    Kumar, P.2    Wang, C.3    DeFea, K.A.4
  • 49
    • 0038514264 scopus 로고    scopus 로고
    • Subcellular localization of β-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus
    • DOI 10.1074/jbc.M208109200
    • Wang P, Wu Y, Ge X, Ma L, Pei G (2003b) Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus. J Biol Chem 278: 11648-11653 (Pubitemid 36792727)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.13 , pp. 11648-11653
    • Wang, P.1    Wu, Y.2    Ge, X.3    Ma, L.4    Pei, G.5
  • 50
    • 51849155581 scopus 로고    scopus 로고
    • Post-translational regulation of PTEN
    • Wang X, Jiang X (2008) Post-translational regulation of PTEN. Oncogene 27: 5454-5463
    • (2008) Oncogene , vol.27 , pp. 5454-5463
    • Wang, X.1    Jiang, X.2
  • 52
    • 34547107639 scopus 로고    scopus 로고
    • β-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2
    • DOI 10.1074/jbc.M701391200
    • Zoudilova M, Kumar P, Ge L, Wang P, Bokoch GM, DeFea KA (2007) Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. J Biol Chem 282: 20634-20646 (Pubitemid 47100047)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.28 , pp. 20634-20646
    • Zoudilova, M.1    Kumar, P.2    Ge, L.3    Wang, P.4    Bokoch, G.M.5    DeFea, K.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.