Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Walker, Chandler L ^a   Walker, Melissa J ^a   Liu, Nai Kui ^a   Risberg, Emelie C ^a   Gao, Xiang ^a   Chen, Jinhui ^a   Xu, Xiao Ming ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; NEUROPROTECTIVE AGENT; POTASSIUM BISPEROXO(PICOLINATO)VANADIUM; PROTEIN KINASE B; UNCLASSIFIED DRUG; BISPEROXOVANADIUM; LC3 PROTEIN, RAT; MICROTUBULE ASSOCIATED PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; TARGET OF RAPAMYCIN KINASE; VANADIUM DERIVATIVE;

ADULT ANIMAL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CERVICAL SPINAL CORD INJURY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; FEMALE; FORELIMB; HISTOPATHOLOGY; MOTONEURON; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; BIOLOGICAL MODEL; CERVICAL SPINE; CONTUSION; CONVALESCENCE; ENZYMOLOGY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHAGOSOME; PHOSPHORYLATION; PROTEIN TRANSPORT; SPINAL CORD INJURY; SPRAGUE DAWLEY RAT; VASCULARIZATION;

MAMMALIA; RATTUS;

ANIMALS; AUTOPHAGY; CERVICAL VERTEBRAE; CONTUSIONS; ENZYME ACTIVATION; FEMALE; FORELIMB; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, BIOLOGICAL; MOTOR NEURONS; NEUROPROTECTIVE AGENTS; PHAGOSOMES; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SIGNAL TRANSDUCTION; SPINAL CORD INJURIES; TOR SERINE-THREONINE KINASES; VANADIUM COMPOUNDS;

EID: 84855588783     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030012     Document Type: Article

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