PTEN at a glance

Journal of Cell Science

Volumn 125, Issue 20, 2012, Pages 4687-4692

  Shi, Yuji ^a   Paluch, Benjamin E ^b   Wang, Xinjiang ^b   Jiang, Xuejun ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE;

ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING;

ACETYLATION; ANIMALS; GENE EXPRESSION REGULATION; HUMANS; MICE; MUTATION; OXIDATION-REDUCTION; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; UBIQUITINATION;

EID: 84872170622     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.093765     Document Type: Article

References (69)

1. Al-Khouri, A. M., Ma, Y., Togo, S. H., Williams, S. and Mustelin, T. (2005). Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta. J. Biol. Chem. 280, 35195-35202.
2. Bar, N. and Dikstein, R. (2010). miR-22 forms a regulatory loop in PTEN/AKT pathway and modulates signaling kinetics. PLoS ONE 5, e10859.
3. Carracedo, A., Alimonti, A. and Pandolfi, P. P. (2011). PTEN level in tumor suppression: how much is too little? Cancer Res. 71, 629-633.
4. Chagpar, R. B., Links, P. H., Pastor, M. C., Furber, L. A., Hawrysh, A. D., Chamberlain, M. D. and Anderson, D. H. (2010). Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. USA 107, 5471-5476.
5. Chalhoub, N. and Baker, S. J. (2009). PTEN and the PI3-kinase pathway in cancer. Annu. Rev. Pathol. 4, 127-150.
6. Chappell, W. H., Green, T. D., Spengeman, J. D., McCubrey, J. A., Akula, S. M. and Bertrand, F. E. (2005). Increased protein expression of the PTEN tumor suppressor in the presence of constitutively active Notch-1. Cell Cycle, 4, 1389-1395.
7. Chen, M., Pratt, C. P., Zeeman, M. E., Schultz, N., Taylor, B. S., O'Neill, A., Castillo-Martin, M., Nowak, D. G., Naguib, A., Grace, D. M. et al. (2011). Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell 20, 173-186.
8. Drinjakovic, J., Jung, H., Campbell, D. S., Strochlic, L., Dwivedy, A. and Holt, C. E. (2010). E3 ligase Nedd4 promotes axon branching by downregulating PTEN. Neuron 65, 341-357.
9. Fine, B., Hodakoski, C., Koujak, S., Su, T., Saal, L. H., Maurer, M., Hopkins, B., Keniry, M., Sulis, M. L., Mense, S. et al. (2009). Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science 325, 1261-1265.
10. Gu, J., Tamura, M., Pankov, R., Danen, E. H., Takino, T., Matsumoto, K. and Yamada, K. M. (1999). Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J. Cell Biol. 146, 389-404.
11. He, L., Ingram, A., Rybak, A. P. and Tang, D. (2010). Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells. J. Clin. Invest. 120, 2094-2108.
12. Heit, B., Robbins, S. M., Downey, C. M., Guan, Z., Colarusso, P., Miller, B. J., Jirik, F. R. and Kubes, P. (2008). PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils. Nat. Immunol. 9, 743-752.
13. Howitt, J., Lackovic, J., Low, L. H., Naguib, A., Macintyre, A., Goh, C. P., Callaway, J. K., Hammond, V., Thomas, T., Dixon, M. et al. (2012). Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. J. Cell Biol. 196, 29-36.
14. Huse, J. T., Brennan, C., Hambardzumyan, D., Wee, B., Pena, J., Rouhanifard, S. H., Sohn-Lee, C., le Sage, C., Agami, R., Tuschl, T. et al. (2009). The PTENregulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes Dev. 23, 1327-1337.
15. Ikenoue, T., Inoki, K., Zhao, B. and Guan, K. L. (2008). PTEN acetylation modulates its interaction with PDZ domain. Cancer Res. 68, 6908-6912.
16. Karreth, F. A., Tay, Y., Perna, D., Ala, U., Tan, S. M., Rust, A. G., DeNicola, G., Webster, K. A., Weiss, D., Perez-Mancera, P. A. et al. (2011). In vivo identification of tumor-suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell 147, 382-395.
17. Kim, J. S., Xu, X., Li, H., Solomon, D., Lane, W. S., Jin, T. and Waldman, T. (2011). Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells. Mol. Cell. Biol. 31, 2756-2771.
18. Kim, Y. C., Kitaura, H., Taira, T., Iguchi-Ariga, S. M. and Ariga, H. (2009). Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN. Int. J. Oncol. 35, 1331-1341.
19. Knobbe, C. B., Lapin, V., Suzuki, A. and Mak, T. W. (2008). The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey. Oncogene 27, 5398-5415.
20. Kwak, Y. D., Ma, T., Diao, S., Zhang, X., Chen, Y., Hsu, J., Lipton, S. A., Masliah, E., Xu, H. and Liao, F. F. (2010a). NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration. Mol. Neurodegener. 5, 49.
21. Kwak, Y. D., Wang, B., Pan, W., Xu, H., Jiang, X. and Liao, F. F. (2010b). Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc. J. Biol. Chem. 285, 9847-9857.
22. Kwon, J., Lee, S. R., Yang, K. S., Ahn, Y., Kim, Y. J., Stadtman, E. R. and Rhee, S. G. (2004). Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors. Proc. Natl. Acad. Sci. USA 101, 16419-16424.
23. Lau, M. T., Klausen, C. and Leung, P. C. (2011). E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via b-catenin-Egr1-mediated PTEN expression. Oncogene 30, 2753-2766.
24. Lee, S. R., Yang, K. S., Kwon, J., Lee, C., Jeong, W. and Rhee, S. G. (2002). Reversible inactivation of the tumor suppressor PTEN by H2O2. J. Biol. Chem. 277, 20336-20342.
25. Lehman, J. A., Waning, D. L., Batuello, C. N., Cipriano, R., Kadakia, M. P. and Mayo, L. D. (2011). Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress. J. Biol. Chem. 286, 36631-36640.
26. Leslie, N. R., Bennett, D., Lindsay, Y. E., Stewart, H., Gray, A. and Downes, C. P. (2003). Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J. 22, 5501-5510.
27. Li, A. G., Piluso, L. G., Cai, X., Wei, G., Sellers, W. R. and Liu, X. (2006). Mechanistic insights into maintenance of high p53 acetylation by PTEN. Mol. Cell 23, 575-587.
28. Li, D. M. and Sun, H. (1997). TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res. 57, 2124-2129.
29. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R. et al. (1997). PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275, 1943-1947.
30. Li, Z., Dong, X., Wang, Z., Liu, W., Deng, N., Ding, Y., Tang, L., Hla, T., Zeng, R., Li, L. et al. (2005). Regulation of PTEN by Rho small GTPases. Nat. Cell Biol. 7, 399-404.
31. Lima-Fernandes, E., Enslen, H., Camand, E., Kotelevets, L., Boularan, C., Achour, L., Benmerah, A., Gibson, L. C., Baillie, G. S., Pitcher, J. A. et al. (2011). Distinct functional outputs of PTEN signalling are controlled by dynamic association with b-arrestins. EMBO J. 30, 2557-2568.
32. Lindsay, Y., McCoull, D., Davidson, L., Leslie, N. R., Fairservice, A., Gray, A., Lucocq, J. and Downes, C. P. (2006). Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression. J. Cell Sci. 119, 5160-5168.
33. Maccario, H., Perera, N. M., Davidson, L., Downes, C. P. and Leslie, N. R. (2007). PTEN is destabilized by phosphorylation on Thr366. Biochem. J. 405, 439-444.
34. Maccario, H., Perera, N. M., Gray, A., Downes, C. P. and Leslie, N. R. (2010). Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress. J. Biol. Chem. 285, 12620-12628.
35. Maddika, S., Kavela, S., Rani, N., Palicharla, V. R., Pokorny, J. L., Sarkaria, J. N. and Chen, J. (2011). WWP2 is an E3 ubiquitin ligase for PTEN. Nat. Cell Biol. 13, 728-733.
36. Maehama, T. and Dixon, J. E. (1998). The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273, 13375-13378.
37. Mahimainathan, L. and Choudhury, G. G. (2004). Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase. J. Biol. Chem. 279, 15258-15268.
38. Martelli, A. M., Evangelisti, C., Chappell, W., Abrams, S. L., Bäsecke, J., Stivala, F., Donia, M., Fagone, P., Nicoletti, F., Libra, M. et al. (2011). Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway. Leukemia 25, 1064-1079.
39. Meng, F., Henson, R., Wehbe-Janek, H., Ghoshal, K., Jacob, S. T. and Patel, T. (2007). MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133, 647-658.
40. Mund, T. and Pelham, H. R. (2010). Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2. Proc. Natl. Acad. Sci. USA 107, 11429-11434.
41. Numajiri, N., Takasawa, K., Nishiya, T., Tanaka, H., Ohno, K., Hayakawa, W., Asada, M., Matsuda, H., Azumi, K., Kamata, H. et al. (2011). On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN). Proc. Natl. Acad. Sci. USA 108, 10349-10354.
42. Odriozola, L., Singh, G., Hoang, T. and Chan, A. M. (2007). Regulation of PTEN activity by its carboxylterminal autoinhibitory domain. J. Biol. Chem. 282, 23306-23315.
43. Okahara, F., Itoh, K., Nakagawara, A., Murakami, M., Kanaho, Y. and Maehama, T. (2006). Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation. Mol. Biol. Cell 17, 4888-4895.
44. Okumura, K., Mendoza, M., Bachoo, R. M., DePinho, R. A., Cavenee, W. K. and Furnari, F. B. (2006). PCAF modulates PTEN activity. J. Biol. Chem. 281, 26562-26568.
45. Palomero, T., Sulis, M. L., Cortina, M., Real, P. J., Barnes, K., Ciofani, M., Caparros, E., Buteau, J., Brown, K., Perkins, S. L. et al. (2007). Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat. Med. 13, 1203-1210.
46. Poliseno, L., Salmena, L., Zhang, J., Carver, B., Haveman, W. J. and Pandolfi, P. P. (2010). A codingindependent function of gene and pseudogene mRNAs regulates tumour biology. Nature 465, 1033-1038.
47. Raftopoulou, M., Etienne-Manneville, S., Self, A., Nicholls, S. and Hall, A. (2004). Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. Science 303, 1179-1181.
48. Rahdar, M., Inoue, T., Meyer, T., Zhang, J., Vazquez, F. and Devreotes, P. N. (2009). A phosphorylationdependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc. Natl. Acad. Sci. USA 106, 480-485.
49. Reddy, P., Liu, L., Adhikari, D., Jagarlamudi, K., Rajareddy, S., Shen, Y., Du, C., Tang, W., Hämäläinen, T., Peng, S. L. et al. (2008). Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool. Science 319, 611-613.
50. Salmena, L., Carracedo, A. and Pandolfi, P. P. (2008). Tenets of PTEN tumor suppression. Cell 133, 403-414. Shen, W. H., Balajee, A. S., Wang, J., Wu, H., Eng, C., Pandolfi, P. P. and Yin, Y. (2007). Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128, 157-170.
51. Shen, W. H., Balajee, A. S., Wang, J., Wu, H., Eng, C., Pandolfi, P. P. and Yin, Y. (2007). Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128, 157-170.
52. Song, L. B., Li, J., Liao, W. T., Feng, Y., Yu, C. P., Hu, L. J., Kong, Q. L., Xu, L. H., Zhang, X., Liu, W. L. et al. (2009). The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelialmesenchymal transition in human nasopharyngeal epithelial cells. J. Clin. Invest. 119, 3626-3636.
53. Song, M. S., Salmena, L., Carracedo, A., Egia, A., Lo-Coco, F., Teruya-Feldstein, J. and Pandolfi, P. P. (2008). The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. Nature 455, 813-817.
54. Song, M. S., Carracedo, A., Salmena, L., Song, S. J., Egia, A., Malumbres, M. and Pandolfi, P. P. (2011). Nuclear PTEN regulates the APC-CDH1 tumorsuppressive complex in a phosphatase-independent manner. Cell 144, 187-199.
55. Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T. et al. (1997).Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet. 15, 356-362.
56. Suzuki, A., Nakano, T., Mak, T. W. and Sasaki, T. (2008). Portrait of PTEN: messages from mutant mice. Cancer Sci. 99, 209-213.
57. Tamguney, T. and Stokoe, D. (2007). New insights into PTEN. J. Cell Sci. 120, 4071-4079.
58. Tamura, M., Gu, J., Matsumoto, K., Aota, S., Parsons, R. and Yamada, K. M. (1998). Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280, 1614-1617.
59. Tamura, M., Gu, J., Takino, T. and Yamada, K. M. (1999). Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas. Cancer Res. 59, 442-449.
60. Torres, J. and Pulido, R. (2001). The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J. Biol. Chem. 276, 993-998.
61. Trotman, L. C., Wang, X., Alimonti, A., Chen, Z., Teruya-Feldstein, J., Yang, H., Pavletich, N. P., Carver, B. S., Cordon-Cardo, C., Erdjument-Bromage, H. et al. (2007). Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 128, 141-156.
62. Van Themsche, C., Leblanc, V., Parent, S. and Asselin, E. (2009). X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization. J. Biol. Chem. 284, 20462-20466.
63. Vazquez, F., Ramaswamy, S., Nakamura, N. and Sellers, W. R. (2000). Phosphorylation of the PTEN tail regulates protein stability and function. Mol. Cell. Biol. 20, 5010-5018.
64. Vazquez, F., Matsuoka, S., Sellers, W. R., Yanagida, T., Ueda, M. and Devreotes, P. N. (2006). Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. Proc. Natl. Acad. Sci. USA 103, 3633-3638.
65. Wang, X., Trotman, L. C., Koppie, T., Alimonti, A., Chen, Z., Gao, Z., Wang, J., Erdjument-Bromage, H., Tempst, P., Cordon-Cardo, C. et al. (2007). NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell 128, 129-139.
66. Wang, X., Shi, Y., Wang, J., Huang, G. and Jiang, X. (2008). Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation. Biochem. J. 414, 221-229.
67. Whelan, J. T., Forbes, S. L. and Bertrand, F. E. (2007). CBF-1 (RBP-J kappa) binds to the PTEN promoter and regulates PTEN gene expression. Cell Cycle, 6, 80-84.
68. Yim, E. K., Peng, G., Dai, H., Hu, R., Li, K., Lu, Y., Mills, G. B., Meric-Bernstam, F., Hennessy, B. T., Craven, R. J. et al. (2009). Rak functions as a tumor suppressor by regulating PTEN protein stability and function. Cancer Cell 15, 304-314.
69. Yim, J. H., Kim, Y. J., Ko, J. H., Cho, Y. E., Kim, S. M., Kim, J. Y., Lee, S. and Park, J. H. (2007). The putative tumor suppressor gene GLTSCR2 induces PTENmodulated cell death. Cell Death Differ. 14, 1872-1879.