메뉴 건너뛰기




Volumn 9, Issue 10, 2013, Pages

Coordinate Regulation of Mature Dopaminergic Axon Morphology by Macroautophagy and the PTEN Signaling Pathway

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; AUTOPHAGY PROTEIN 7; CRE RECOMBINASE; GEPHRIN; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; NEUROMODULIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; POSTSYNAPTIC DENSITY PROTEIN 95; SYNAPSIN I; SYNAPTIC VESICLE PROTEIN 2A; SYNAPTOPHYSIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNAPTOTAGMIN; SYNTAXIN 1A; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

EID: 84887305258     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003845     Document Type: Article
Times cited : (19)

References (59)
  • 1
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: molecular mechanisms and biological functions of autophagy
    • Levine B, Klionsky DJ, (2004) Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6: 463-477.
    • (2004) Dev Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 2
    • 33745201600 scopus 로고    scopus 로고
    • Neurodegeneration: good riddance to bad rubbish
    • Klionsky DJ, (2006) Neurodegeneration: good riddance to bad rubbish. Nature 441: 819-820.
    • (2006) Nature , vol.441 , pp. 819-820
    • Klionsky, D.J.1
  • 3
    • 33745192802 scopus 로고    scopus 로고
    • Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    • Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, et al. (2006) Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441: 885-889.
    • (2006) Nature , vol.441 , pp. 885-889
    • Hara, T.1    Nakamura, K.2    Matsui, M.3    Yamamoto, A.4    Nakahara, Y.5
  • 4
    • 33646800306 scopus 로고    scopus 로고
    • Loss of autophagy in the central nervous system causes neurodegeneration in mice
    • Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, et al. (2006) Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441: 880-884.
    • (2006) Nature , vol.441 , pp. 880-884
    • Komatsu, M.1    Waguri, S.2    Chiba, T.3    Murata, S.4    Iwata, J.5
  • 5
    • 35448938087 scopus 로고    scopus 로고
    • Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration
    • Komatsu M, Wang QJ, Holstein GR, Friedrich VL Jr, Iwata J, et al. (2007) Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A 104: 14489-14494.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 14489-14494
    • Komatsu, M.1    Wang, Q.J.2    Holstein, G.R.3    Friedrich Jr., V.L.4    Iwata, J.5
  • 6
    • 35848944122 scopus 로고    scopus 로고
    • Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death
    • Nishiyama J, Miura E, Mizushima N, Watanabe M, Yuzaki M, (2007) Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death. Autophagy 3: 591-596.
    • (2007) Autophagy , vol.3 , pp. 591-596
    • Nishiyama, J.1    Miura, E.2    Mizushima, N.3    Watanabe, M.4    Yuzaki, M.5
  • 8
    • 0035733762 scopus 로고    scopus 로고
    • Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
    • Backman SA, Stambolic V, Suzuki A, Haight J, Elia A, et al. (2001) Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet 29: 396-403.
    • (2001) Nat Genet , vol.29 , pp. 396-403
    • Backman, S.A.1    Stambolic, V.2    Suzuki, A.3    Haight, J.4    Elia, A.5
  • 9
    • 0035734381 scopus 로고    scopus 로고
    • Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease
    • Kwon CH, Zhu X, Zhang J, Knoop LL, Tharp R, et al. (2001) Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat Genet 29: 404-411.
    • (2001) Nat Genet , vol.29 , pp. 404-411
    • Kwon, C.H.1    Zhu, X.2    Zhang, J.3    Knoop, L.L.4    Tharp, R.5
  • 10
    • 33646142995 scopus 로고    scopus 로고
    • Pten regulates neuronal arborization and social interaction in mice
    • Kwon CH, Luikart BW, Powell CM, Zhou J, Matheny SA, et al. (2006) Pten regulates neuronal arborization and social interaction in mice. Neuron 50: 377-388.
    • (2006) Neuron , vol.50 , pp. 377-388
    • Kwon, C.H.1    Luikart, B.W.2    Powell, C.M.3    Zhou, J.4    Matheny, S.A.5
  • 11
    • 67650601691 scopus 로고    scopus 로고
    • Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains
    • Chalhoub N, Zhu G, Zhu X, Baker SJ, (2009) Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains. Genes Dev 23: 1619-1624.
    • (2009) Genes Dev , vol.23 , pp. 1619-1624
    • Chalhoub, N.1    Zhu, G.2    Zhu, X.3    Baker, S.J.4
  • 12
    • 79952770185 scopus 로고    scopus 로고
    • Pten knockdown in vivo increases excitatory drive onto dentate granule cells
    • Luikart BW, Schnell E, Washburn EK, Bensen AL, Tovar KR, et al. (2011) Pten knockdown in vivo increases excitatory drive onto dentate granule cells. J Neurosci 31: 4345-4354.
    • (2011) J Neurosci , vol.31 , pp. 4345-4354
    • Luikart, B.W.1    Schnell, E.2    Washburn, E.K.3    Bensen, A.L.4    Tovar, K.R.5
  • 13
    • 84856904410 scopus 로고    scopus 로고
    • Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration
    • Sperow M, Berry RB, Bayazitov IT, Zhu G, Baker SJ, et al. (2012) Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration. J Physiol 590: 777-792.
    • (2012) J Physiol , vol.590 , pp. 777-792
    • Sperow, M.1    Berry, R.B.2    Bayazitov, I.T.3    Zhu, G.4    Baker, S.J.5
  • 14
    • 70349168685 scopus 로고    scopus 로고
    • Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons
    • Diaz-Ruiz O, Zapata A, Shan L, Zhang Y, Tomac AC, et al. (2009) Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons. PLoS One 4: e7027.
    • (2009) PLoS One , vol.4
    • Diaz-Ruiz, O.1    Zapata, A.2    Shan, L.3    Zhang, Y.4    Tomac, A.C.5
  • 15
    • 80052668585 scopus 로고    scopus 로고
    • Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models
    • Domanskyi A, Geissler C, Vinnikov IA, Alter H, Schober A, et al. (2011) Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models. FASEB J 25: 2898-2910.
    • (2011) FASEB J , vol.25 , pp. 2898-2910
    • Domanskyi, A.1    Geissler, C.2    Vinnikov, I.A.3    Alter, H.4    Schober, A.5
  • 16
    • 84866519178 scopus 로고    scopus 로고
    • Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway
    • Inoue K, Rispoli J, Kaphzan H, Klann E, Chen EI, et al. (2012) Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener 7: 48.
    • (2012) Mol Neurodegener , vol.7 , pp. 48
    • Inoue, K.1    Rispoli, J.2    Kaphzan, H.3    Klann, E.4    Chen, E.I.5
  • 17
    • 14844290256 scopus 로고    scopus 로고
    • Targeted gene expression in dopamine and serotonin neurons of the mouse brain
    • Zhuang X, Masson J, Gingrich JA, Rayport S, Hen R, (2005) Targeted gene expression in dopamine and serotonin neurons of the mouse brain. J Neurosci Methods 143: 27-32.
    • (2005) J Neurosci Methods , vol.143 , pp. 27-32
    • Zhuang, X.1    Masson, J.2    Gingrich, J.A.3    Rayport, S.4    Hen, R.5
  • 18
    • 21044455137 scopus 로고    scopus 로고
    • Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
    • Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, et al. (2005) Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169: 425-434.
    • (2005) J Cell Biol , vol.169 , pp. 425-434
    • Komatsu, M.1    Waguri, S.2    Ueno, T.3    Iwata, J.4    Murata, S.5
  • 19
    • 84861595545 scopus 로고    scopus 로고
    • Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of alpha-synuclein and LRRK2 in the brain
    • Friedman LG, Lachenmayer ML, Wang J, He L, Poulose SM, et al. (2012) Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of alpha-synuclein and LRRK2 in the brain. J Neurosci 32: 7585-7593.
    • (2012) J Neurosci , vol.32 , pp. 7585-7593
    • Friedman, L.G.1    Lachenmayer, M.L.2    Wang, J.3    He, L.4    Poulose, S.M.5
  • 20
    • 84869041395 scopus 로고    scopus 로고
    • Development and characterization of a new Parkinson's disease model resulting from impaired autophagy
    • Ahmed I, Liang Y, Schools S, Dawson VL, Dawson TM, et al. (2012) Development and characterization of a new Parkinson's disease model resulting from impaired autophagy. J Neurosci 32: 16503-16509.
    • (2012) J Neurosci , vol.32 , pp. 16503-16509
    • Ahmed, I.1    Liang, Y.2    Schools, S.3    Dawson, V.L.4    Dawson, T.M.5
  • 22
    • 0036801311 scopus 로고    scopus 로고
    • PTEN function in mammalian cell size regulation
    • Backman S, Stambolic V, Mak T, (2002) PTEN function in mammalian cell size regulation. Curr Opin Neurobiol 12: 516-522.
    • (2002) Curr Opin Neurobiol , vol.12 , pp. 516-522
    • Backman, S.1    Stambolic, V.2    Mak, T.3
  • 23
    • 0242268407 scopus 로고    scopus 로고
    • mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo
    • Kwon CH, Zhu X, Zhang J, Baker SJ, (2003) mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo. Proc Natl Acad Sci U S A 100: 12923-12928.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12923-12928
    • Kwon, C.H.1    Zhu, X.2    Zhang, J.3    Baker, S.J.4
  • 24
    • 81055144784 scopus 로고    scopus 로고
    • Autophagy: renovation of cells and tissues
    • Mizushima N, Komatsu M, (2011) Autophagy: renovation of cells and tissues. Cell 147: 728-741.
    • (2011) Cell , vol.147 , pp. 728-741
    • Mizushima, N.1    Komatsu, M.2
  • 25
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N, (2004) Upstream and downstream of mTOR. Genes Dev 18: 1926-1945.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 26
  • 28
    • 33745030531 scopus 로고    scopus 로고
    • Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo
    • Nguyen KT, Tajmir P, Lin CH, Liadis N, Zhu XD, et al. (2006) Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo. Mol Cell Biol 26: 4511-4518.
    • (2006) Mol Cell Biol , vol.26 , pp. 4511-4518
    • Nguyen, K.T.1    Tajmir, P.2    Lin, C.H.3    Liadis, N.4    Zhu, X.D.5
  • 29
    • 33645217126 scopus 로고    scopus 로고
    • Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes
    • Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, et al. (2006) Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol 26: 2772-2781.
    • (2006) Mol Cell Biol , vol.26 , pp. 2772-2781
    • Stiles, B.L.1    Kuralwalla-Martinez, C.2    Guo, W.3    Gregorian, C.4    Wang, Y.5
  • 30
    • 33745904748 scopus 로고    scopus 로고
    • S6k1 is not required for Pten-deficient neuronal hypertrophy
    • Chalhoub N, Kozma SC, Baker SJ, (2006) S6k1 is not required for Pten-deficient neuronal hypertrophy. Brain Res 1100: 32-41.
    • (2006) Brain Res , vol.1100 , pp. 32-41
    • Chalhoub, N.1    Kozma, S.C.2    Baker, S.J.3
  • 31
    • 70449727080 scopus 로고    scopus 로고
    • Autophagy promotes synapse development in Drosophila
    • Shen W, Ganetzky B, (2009) Autophagy promotes synapse development in Drosophila. J Cell Biol 187: 71-79.
    • (2009) J Cell Biol , vol.187 , pp. 71-79
    • Shen, W.1    Ganetzky, B.2
  • 32
    • 0022358866 scopus 로고
    • Axonal guidance mutants of Caenorhabditis elegans identified by filling sensory neurons with fluorescein dyes
    • Hedgecock EM, Culotti JG, Thomson JN, Perkins LA, (1985) Axonal guidance mutants of Caenorhabditis elegans identified by filling sensory neurons with fluorescein dyes. Dev Biol 111: 158-170.
    • (1985) Dev Biol , vol.111 , pp. 158-170
    • Hedgecock, E.M.1    Culotti, J.G.2    Thomson, J.N.3    Perkins, L.A.4
  • 33
    • 33845874899 scopus 로고    scopus 로고
    • Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death
    • Scott RC, Juhasz G, Neufeld TP, (2007) Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol 17: 1-11.
    • (2007) Curr Biol , vol.17 , pp. 1-11
    • Scott, R.C.1    Juhasz, G.2    Neufeld, T.P.3
  • 34
    • 1642417689 scopus 로고    scopus 로고
    • Role of Unc51.1 and its binding partners in CNS axon outgrowth
    • Tomoda T, Kim JH, Zhan C, Hatten ME, (2004) Role of Unc51.1 and its binding partners in CNS axon outgrowth. Genes Dev 18: 541-558.
    • (2004) Genes Dev , vol.18 , pp. 541-558
    • Tomoda, T.1    Kim, J.H.2    Zhan, C.3    Hatten, M.E.4
  • 35
    • 57749095080 scopus 로고    scopus 로고
    • UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly
    • Toda H, Mochizuki H, Flores R, (2008) UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly. Genes Dev 22: 3292-3307.
    • (2008) Genes Dev , vol.22 , pp. 3292-3307
    • Toda, H.1    Mochizuki, H.2    Flores, R.3
  • 36
    • 38049160310 scopus 로고    scopus 로고
    • Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen
    • Loh SH, Francescut L, Lingor P, Bahr M, Nicotera P, (2008) Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen. Cell Death Differ 15: 283-298.
    • (2008) Cell Death Differ , vol.15 , pp. 283-298
    • Loh, S.H.1    Francescut, L.2    Lingor, P.3    Bahr, M.4    Nicotera, P.5
  • 37
    • 33746647820 scopus 로고    scopus 로고
    • Neurotrophin signaling: many exciting surprises!
    • Arevalo JC, Wu SH, (2006) Neurotrophin signaling: many exciting surprises!. Cell Mol Life Sci 63: 1523-1537.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 1523-1537
    • Arevalo, J.C.1    Wu, S.H.2
  • 38
    • 33749010358 scopus 로고    scopus 로고
    • Neurotrophin-regulated signalling pathways
    • Reichardt LF, (2006) Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci 361: 1545-1564.
    • (2006) Philos Trans R Soc Lond B Biol Sci , vol.361 , pp. 1545-1564
    • Reichardt, L.F.1
  • 39
    • 0028834063 scopus 로고
    • Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
    • Tomac A, Lindqvist E, Lin LF, Ogren SO, Young D, et al. (1995) Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 373: 335-339.
    • (1995) Nature , vol.373 , pp. 335-339
    • Tomac, A.1    Lindqvist, E.2    Lin, L.F.3    Ogren, S.O.4    Young, D.5
  • 40
    • 0028898505 scopus 로고
    • Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo
    • Hudson J, Granholm AC, Gerhardt GA, Henry MA, Hoffman A, et al. (1995) Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo. Brain Res Bull 36: 425-432.
    • (1995) Brain Res Bull , vol.36 , pp. 425-432
    • Hudson, J.1    Granholm, A.C.2    Gerhardt, G.A.3    Henry, M.A.4    Hoffman, A.5
  • 41
    • 0034097605 scopus 로고    scopus 로고
    • Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model
    • Rosenblad C, Kirik D, Bjorklund A, (2000) Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model. Exp Neurol 161: 503-516.
    • (2000) Exp Neurol , vol.161 , pp. 503-516
    • Rosenblad, C.1    Kirik, D.2    Bjorklund, A.3
  • 43
    • 84877342306 scopus 로고    scopus 로고
    • Cell biology. Unconventional secretion, unconventional solutions
    • Zhang M, Schekman R, (2013) Cell biology. Unconventional secretion, unconventional solutions. Science 340: 559-561.
    • (2013) Science , vol.340 , pp. 559-561
    • Zhang, M.1    Schekman, R.2
  • 44
    • 67650750977 scopus 로고    scopus 로고
    • A synaptic trek to autism
    • Bourgeron T, (2009) A synaptic trek to autism. Curr Opin Neurobiol 19: 231-234.
    • (2009) Curr Opin Neurobiol , vol.19 , pp. 231-234
    • Bourgeron, T.1
  • 45
    • 84880297402 scopus 로고    scopus 로고
    • Progress toward treatments for synaptic defects in autism
    • Delorme R, Ey E, Toro R, Leboyer M, Gillberg C, et al. (2013) Progress toward treatments for synaptic defects in autism. Nat Med 19: 685-694.
    • (2013) Nat Med , vol.19 , pp. 685-694
    • Delorme, R.1    Ey, E.2    Toro, R.3    Leboyer, M.4    Gillberg, C.5
  • 46
    • 73849108267 scopus 로고    scopus 로고
    • Brain serotonin and dopamine transporter bindings in adults with high-functioning autism
    • Nakamura K, Sekine Y, Ouchi Y, Tsujii M, Yoshikawa E, et al. (2010) Brain serotonin and dopamine transporter bindings in adults with high-functioning autism. Arch Gen Psychiatry 67: 59-68.
    • (2010) Arch Gen Psychiatry , vol.67 , pp. 59-68
    • Nakamura, K.1    Sekine, Y.2    Ouchi, Y.3    Tsujii, M.4    Yoshikawa, E.5
  • 47
    • 77956799683 scopus 로고    scopus 로고
    • Association of DRD4 polymorphism with severity of oppositional defiant disorder, separation anxiety disorder and repetitive behaviors in children with autism spectrum disorder
    • Gadow KD, Devincent CJ, Olvet DM, Pisarevskaya V, Hatchwell E, (2010) Association of DRD4 polymorphism with severity of oppositional defiant disorder, separation anxiety disorder and repetitive behaviors in children with autism spectrum disorder. Eur J Neurosci 32: 1058-1065.
    • (2010) Eur J Neurosci , vol.32 , pp. 1058-1065
    • Gadow, K.D.1    Devincent, C.J.2    Olvet, D.M.3    Pisarevskaya, V.4    Hatchwell, E.5
  • 50
    • 67349182343 scopus 로고    scopus 로고
    • Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
    • Glessner JT, Wang K, Cai G, Korvatska O, Kim CE, et al. (2009) Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature 459: 569-573.
    • (2009) Nature , vol.459 , pp. 569-573
    • Glessner, J.T.1    Wang, K.2    Cai, G.3    Korvatska, O.4    Kim, C.E.5
  • 51
    • 67651233780 scopus 로고    scopus 로고
    • Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes
    • Bucan M, Abrahams BS, Wang K, Glessner JT, Herman EI, et al. (2009) Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. PLoS Genet 5: e1000536.
    • (2009) PLoS Genet , vol.5
    • Bucan, M.1    Abrahams, B.S.2    Wang, K.3    Glessner, J.T.4    Herman, E.I.5
  • 52
    • 79955119884 scopus 로고    scopus 로고
    • PARK2 copy number aberrations in two children presenting with autism spectrum disorder: further support of an association and possible evidence for a new microdeletion/microduplication syndrome
    • Scheuerle A, Wilson K, (2011) PARK2 copy number aberrations in two children presenting with autism spectrum disorder: further support of an association and possible evidence for a new microdeletion/microduplication syndrome. Am J Med Genet B Neuropsychiatr Genet 156B: 413-420.
    • (2011) Am J Med Genet B Neuropsychiatr Genet , vol.156 B , pp. 413-420
    • Scheuerle, A.1    Wilson, K.2
  • 53
    • 0035824396 scopus 로고    scopus 로고
    • Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo
    • Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, et al. (2001) Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 294: 2186-2189.
    • (2001) Science , vol.294 , pp. 2186-2189
    • Groszer, M.1    Erickson, R.2    Scripture-Adams, D.D.3    Lesche, R.4    Trumpp, A.5
  • 54
    • 0036135209 scopus 로고    scopus 로고
    • Hypolocomotor effects of acute and daily d-amphetamine in mice lacking the dopamine transporter
    • Spielewoy C, Biala G, Roubert C, Hamon M, Betancur C, et al. (2001) Hypolocomotor effects of acute and daily d-amphetamine in mice lacking the dopamine transporter. Psychopharmacology (Berl) 159: 2-9.
    • (2001) Psychopharmacology (Berl) , vol.159 , pp. 2-9
    • Spielewoy, C.1    Biala, G.2    Roubert, C.3    Hamon, M.4    Betancur, C.5
  • 55
    • 0347379769 scopus 로고    scopus 로고
    • Regional and subcellular compartmentation of the dopamine transporter and tyrosine hydroxylase in the rat ventral pallidum
    • Mengual E, Pickel VM, (2004) Regional and subcellular compartmentation of the dopamine transporter and tyrosine hydroxylase in the rat ventral pallidum. J Comp Neurol 468: 395-409.
    • (2004) J Comp Neurol , vol.468 , pp. 395-409
    • Mengual, E.1    Pickel, V.M.2
  • 56
    • 33751256567 scopus 로고    scopus 로고
    • The familial Parkinsonism gene LRRK2 regulates neurite process morphology
    • MacLeod D, Dowman J, Hammond R, Leete T, Inoue K, et al. (2006) The familial Parkinsonism gene LRRK2 regulates neurite process morphology. Neuron 52: 587-593.
    • (2006) Neuron , vol.52 , pp. 587-593
    • MacLeod, D.1    Dowman, J.2    Hammond, R.3    Leete, T.4    Inoue, K.5
  • 57
    • 0030904958 scopus 로고    scopus 로고
    • Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake
    • Teng L, Crooks PA, Sonsalla PK, Dwoskin LP, (1997) Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake. J Pharmacol Exp Ther 280: 1432-1444.
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 1432-1444
    • Teng, L.1    Crooks, P.A.2    Sonsalla, P.K.3    Dwoskin, L.P.4
  • 58
    • 10144229354 scopus 로고    scopus 로고
    • A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities
    • Yang L, Calingasan NY, Chen J, Ley JJ, Becker DA, et al. (2005) A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities. Exp Neurol 191: 86-93.
    • (2005) Exp Neurol , vol.191 , pp. 86-93
    • Yang, L.1    Calingasan, N.Y.2    Chen, J.3    Ley, J.J.4    Becker, D.A.5
  • 59
    • 1942487359 scopus 로고    scopus 로고
    • Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice
    • Iwasato T, Nomura R, Ando R, Ikeda T, Tanaka M, et al. (2004) Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice. Genesis 38: 130-138.
    • (2004) Genesis , vol.38 , pp. 130-138
    • Iwasato, T.1    Nomura, R.2    Ando, R.3    Ikeda, T.4    Tanaka, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.