The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells

Science Signaling

Volumn 5, Issue 243, 2012, Pages

  Putz, Ulrich ^a   Howitt, Jason ^a   Doan, Anh ^a   Goh, Choo Peng ^a   Low, Ley Hian ^a   Silke, John ^a   Tan, Seong Seng ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; LYSINE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN NDFIP1; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE NEDD4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; EXOSOME; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN TRANSPORT;

ANIMALS; BLOTTING, WESTERN; CARRIER PROTEINS; CELL PROLIFERATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; EXOSOMES; HEK293 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; PTEN PHOSPHOHYDROLASE; TETRAZOLIUM SALTS; THIAZOLES; TRYPAN BLUE; UBIQUITIN-PROTEIN LIGASES;

EID: 84866857904     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2003084     Document Type: Article

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