A role for nuclear PTEN in neuronal differentiation

Journal of Neuroscience

Volumn 20, Issue 4, 2000, Pages 1404-1413

  Lachyankar, Mahesh B ^a   Sultana, Nazneen ^a   Schonhoff, Christopher M ^a   Mitra, Prasenjit ^a   Poluha, Wojciech ^a   Lambert, Stephen ^a   Quesenberry, Peter J ^a   Litofsky, N Scott ^a   Recht, Lawrence D ^a   Nabi, Roya ^b   Miller, Susan J ^c   Ohta, Shinji ^c   Neel, Benjamin G ^c   Ross, Alonzo H ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b Life Science and Bioengineering Center   (United States)

^c Division of Hematology and Oncology   (United States)

Author keywords

Brain derived neurotrophic factor; Nerve growth factor; Neurite extension; PC12 cells; Phosphatase; Phosphatidylinositol phosphate; Stem cells

Indexed keywords

NERVE GROWTH FACTOR; PHOSPHATASE; POLYPHOSPHOINOSITIDE;

ANIMAL CELL; ARTICLE; BRAIN TUMOR; CELL DIFFERENTIATION; CHROMOSOME 10; DNA SEQUENCE; GENE EXPRESSION; GENE MUTATION; GLIOMA; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; STEM CELL; TUMOR SUPPRESSOR GENE;

EID: 0034652102     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-04-01404.2000     Document Type: Article

References (58)

1. Ahmed S, Reynolds BA, Weiss S (1995) BDNF enhances the differentiation but not the survival of CNS stem cell-derived neuronal precursors. J Neurosci 15:5765-5778.
2. Andjelkovic M, Alessi DR, Meier R, Fernandez A, Lamb NJC, Frech M, Cron P, Cohen P, Lucocq JM, Hemmings BA (1997) Role of translocation in the activation and function of protein kinase B. J Biol Chem 272:31515-31524.
3. Blair LAC, Marshall J (1997) IGF-1 modulates N and L calcium channels in a PI 3-kinase-dependent manner. Neuron 19:421-429.
4. Blair LAC, Bence-Hanulee KK, Mehta S, Franke T, Kaplan D, Marshall J (1999) Akt-dependent potentiation of L channels by insulin-like growth factor-1 is required for neuronal survival. J Neurosci 19:1940-1951.
5. Boronenkov IV, Loijens JC, Umeda M, Anderson RA (1998) Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors. Mol Biol Cell 9:3547-3560.
6. Cahill MA, Janknecht R, Nordheim A (1996) Signalling pathways: jack of all cascades. Curr Biol 6:16-19.
7. Caramelli E, Matteucci A, Zini N, Carini C, Guidotti L, Ricci D, Maraldi NM, Capitani S (1996) Nuclear phosphoinositide-specific phospholipase C, phosphatidylinositol 4,5-bisphosphate and protein kinase C during rat spermatogenesis. Eur J Cell Biol 71:154-164.
8. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241.
9. Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP (1998) Pten is essential for embryonic development and tumour suppression. Nat Genet 19:348-355.
10. +/- mice. Science 285:2122-2125.
11. Eng C, Murday V, Seal S, Mohammed S, Hodgson SV, Chardary MA, Fentiman IS, Ponder BAJ, Eeles RA (1994) Cowden syndrome and Lhermitte-Duclos disease in a family: a single genetic syndrome with pleiotropy? J Med Genet 31:458-461.
12. Folli F, Bonfanti L, Renard E, Kahn CR, Merighi A (1994) Insulin receptor substrate-1 (IRS-1) distribution in the rat central nervous system. J Neurosci 14:6412-6422.
13. Frevert EU, Kahn BB (1997) Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes. Mol Cell Biol 17:190-198.
14. 1 growth arrest in glioma cells. Cancer Res 58:5002-5008.
15. Gollapudi L, Neet KE (1997) Different mechanisms for inhibition of cell proliferation via cell cycle proteins in PC12 cells by nerve growth factor and staurosporine. J Neurosci Res 49:461-474.
16. Gorlin RJ, Cohen MM, Condon LM, Burke BA (1992) Bannayan-Riley-Ruvalcaba syndrome. Am J Med Genet 44:307-314.
17. Gu J, Tamura M, Yamada KM (1998) Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J Cell Biol 143:1375-1383.
18. Hardingham GE, Chawla S, Cruzalegui FH, Bading H (1999) Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels. Neuron 22:789-798.
19. 1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev 12:3675-3685.
20. Hu S-C, Chrivia J, Ghosh A (1999) Regulation of CBP-mediated transcription by neuronal calcium signaling. Neuron 22:799-808.
21. Ito Y, Goto K, Kondo H (1995) Localization of mRNA for phosphatidylinositol 3-kinase in brain of developing and mature rats. Mol Brain Res 34:149-153.
22. Kimura K, Hattori S, Kabuyama Y, Shizawa Y, Takayanagi J, Nakamura S, Toki S, Matsuda Y, Onodera K, Fukui Y (1994) Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase. J Biol Chem 269:18961-18967.
23. Klippel A, Escobedo M-A, Wachowicz MS, Apell G, Brown TW, Giedlin MA, Kavanaugh WM, Williams LT (1998) Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation. Mol Cell Biol 18:5699-5711.
24. Kobayashi M, Nagata S, Kita Y, Nakatsu N, Ihara S, Kaibuchi K, Kuroda S, Ui M, Iba H, Konishi H, Kikkawa U, Saitoh I, Fukui Y (1997) Expression of a constitutively active phosphatidylinositol 3-kinase induces process formation in rat PC12 cells. J Biol Chem 272:16089-16092.
25. Lachyankar MB, Condon PJ, Quesenberry PJ, Litofsky NS, Recht LD, Ross AH (1997) Embryonic precursor cells that express Trk receptors: induction of different cell fates by NGF, BDNF, NT-3, and CNTF. Exp Neurol 144:350-360.
26. Li D-M, Sun H (1997) TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor β. Cancer Res 57:2124-2129.
27. 1 cell cycle arrest in human glioblastoma cells. Proc Natl Acad Sci USA 95:15406-15411.
28. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275:1943-1947.
29. Liaw D, Marsh DJ, Li J, Dahia PLM, Wang SI, Zheng Z, Bose S, Call KM, Tsou HC, Peacocke M, Eng C, Parsons R (1997) Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 16:64-67.
30. Lu P-J, HSU A-L, Wang D-S, Yan HY, Yin HL, Chen C-S (1998) Phosphoinositide 3-kinase in rat liver nuclei. Biochemistry 37:5738-5745.
31. Maehama T, Dixon JE (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-triphosphate. J Biol Chem 273:13375-13378.
32. 1 in insulin-like growth factor I-induced mitogenesis. Cancer Res 57:2137-2139.
33. Mazzotti G, Zini N, Rizzi E, Rizzoli R, Galanzi A, Ognibene A, Santi S, Matteucci A, Martelli AM, Maraldi NM (1995) Immunocytochemical detection of phosphatidylinositol 4,5-bisphosphate localization sites within the nucleus. J Histochem Cytochem 43:181-191.
34. Meier R, Alessi DR, Cron P, Andjelkovic M, Hemmings BA (1997) Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bβ. J Biol Chem 272:30491-30497.
35. Myers MP, Stolarov JP, Eng C, Li J, Wang SI, Wigler MH, Parsons R, Tonks NK (1997) P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci USA 94:9052-9057.
36. Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP, Tonks NK (1998) The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc Natl Acad Sci USA 95:13513-13518.
37. Neri LM, Milani D, Bertolaso L, Stroscio M, Bertagnolo V, Capitani S (1994) Nuclear translocation of phosphatidylinositol 3-kinase in rat pheochromocytoma PC12 cells after treatment with nerve growth factor. Cell Mol Biol 40:619-626.
38. Neri LM, Borgatti P, Capitani S, Martelli AM (1998) Nuclear diacylglycerol produced by phosphoinositide-specific phospholipase C is responsible for nuclear translocation of protein kinase C-α. J Biol Chem 273:29738-29744.
39. Noble M, Mayer-Proschel M (1997) Growth factors, glia and gliomas. J Neurooncol 35:193-209.
40. Ohmori Y, Schreiber RD, Hamilton TA (1997) Synergy between interferon-γ and tumor necrosis factor-α in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor κΒB. J Biol Chem 272:14899-14907.
41. WAK1 is required for survival of differentiating neuroblastoma cells. Mol Cell Biol 16:1335-1341.
42. WAF1 regulates neuronal differentiation of PC12 cells. J Biol Chem 272:24002-24007.
43. Reinhold DS, Neet KE (1989) The lack of a role for protein kinase C in neurite extension and in the induction of ornithine decarboxylase by nerve growth factor in PC12 cells. J Biol Chem 264:3538-3544.
44. Reynolds BA, Weiss S (1992) Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255:1707-1710.
45. Reynolds BA, Tetzlaff W, Weiss S (1992) A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes. J Neurosci 12:4565-4574.
46. Shaw G, Weber K (1982) Differential expression of neurofilament triplet proteins in brain development. Nature 298:277-279.
47. Shi L, Nishioka WK, Th'ng J, Bradbury EM, Litchfield DW, Greenberg AH (1994) Premature p34cdc2 activation required for apoptosis. Science 263:1143-1145.
48. Shin B-C, Suzuki M, Inukai K, Anai M, Asano T, Takata K (1998) Multiple isoforms of the regulatory subunit for phosphatidylinositol 3-kinase (PI3-kinase) are expressed in neurons in the rat brain. Biochem Biophys Res Commun 246:313-319.
49. Stambolic V, Suzuki A, Lois de la Pompa J, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP, Mak TW (1998) Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95:29-39.
50. Steck PA, Pershouse MA, Jasser SA, Yung WKA, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DHF, Tavtigian SV (1997) Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15:356-362.
51. Stein CA (1996) Phosphorothioate antisense oligodeoxynucleotides: questions of specificity. Trends Biotechnol 14:147-149.
52. 2/M phase transition. J Biol Chem 272:26313-26317.
53. Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco Barrantes I, Ho A, Wakeham A, Itie A, Khoo W, Fukumoto M, Mak TW (1998) High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol 8:1169-1178.
54. Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada KM (1998) Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280:1614-1617.
55. Tanaka K, Horiguchi K, Yoshida T, Takeda M, Fujisawa H, Takeuchi K, Umeda M, Kato S, Ihara S, Nagata S, Fukui Y (1999) Evidence that a phosphatidylinositol 3,4,5-triphosphate-binding protein can function in nucleus. J Biol Chem 274:3919-3922.
56. Willert K, Nusse R (1998) Beta-catenin: a key mediator of Wnt signaling. Curr Opin Genet Dev 8:95-102.
57. Yang H, Raizada MK (1999) Role of phosphatidylinositol 3-kinase in angiotensin II regulation of norepinephrine neuromodulation in brain neurons of the spontaneously hypertensive rat. J Neurosci 19:2413-2423.
58. Zini N, Ognibene A, Bavelloni A, Santi S, Sabatelli P, Baldini N, Scotlandi K, Serra M, Maraldi NM (1996) Cytoplasmic and nuclear localization sites of phosphatidylinositol 3-kinase in human osteosarcoma sensitive and multidrug-resistant Saos-2 cells. Histochem Cell Biol 106:457-464.