Differential role of PTEN phosphatase in chemotactic growth cone guidance

Journal of Biological Chemistry

Volumn 288, Issue 29, 2013, Pages 20837-20842

  Henle, Steven J ^a,d   Carlstrom, Lucas P ^b   Cheever, Thomas R ^a   Henley, John R ^a,c  

^a Department of Neurologic Surgery ^*  (United States)

^b Medical Scientist Training Program   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTION; CHEMOREPULSION; GROWTH CONE GUIDANCE; INTEGRINS; PHOSPHATIDYLINOSITOL;

SELF ASSEMBLY;

PHOSPHATASES;

BETA1 INTEGRIN; GLYCOPROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; CYCLIC AMP; MYELIN ASSOCIATED GLYCOPROTEIN; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5-TRIPHOSPHATE; POLYPHOSPHOINOSITIDE; PTEN PROTEIN, XENOPUS; XENOPUS PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOSENSOR; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; EMBRYO; GROWTH CONE; IMMUNOFLUORESCENCE; IMMUNOFLUORESCENCE TEST; MICROENVIRONMENT; MOLECULAR DYNAMICS; MORPHOLOGY; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; SEQUENCE HOMOLOGY; TRANSCRIPTION INITIATION SITE; ANIMAL; CHEMOTAXIS; CLUSTER ANALYSIS; DRUG EFFECTS; ENDOCYTOSIS; ENZYMOLOGY; METABOLISM; XENOPUS LAEVIS;

ANIMALS; ANTIGENS, CD29; CHEMOTAXIS; CLUSTER ANALYSIS; CYCLIC AMP; DOWN-REGULATION; ENDOCYTOSIS; GROWTH CONES; MYELIN-ASSOCIATED GLYCOPROTEIN; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHORIC MONOESTER HYDROLASES; XENOPUS LAEVIS; XENOPUS PROTEINS;

EID: 84880554229     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C113.487066     Document Type: Article

References (33)

1. Giger, R. J., Hollis, E. R., 2nd, and Tuszynski, M. H. (2010) Guidance molecules in axon regeneration. Cold Spring Harb. Perspect. Biol. 2, a001867
2. Huberman, A. D., Clandinin, T. R., and Baier, H. (2010) Molecular and cellular mechanisms of lamina-specific axon targeting. Cold Spring Harb. Perspect. Biol. 2, a001743
3. Henley, J. R., Huang, K. H., Wang, D., and Poo, M. M. (2004) Calcium mediates bidirectional growth cone turning induced by myelin-associated glycoprotein. Neuron 44, 909 -916
4. Zheng, J. Q., Felder, M., Connor, J. A., and Poo, M. M. (1994) Turning of nerve growth cones induced by neurotransmitters. Nature 368,140-144
5. Ming, G., Song, H., Berninger, B., Inagaki, N., Tessier-Lavigne, M., and Poo, M. (1999) Phospholipase C-7 and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance. Neuron 23, 139-148
6. Hong, K., Nishiyama, M., Henley, J., Tessier-Lavigne, M., and Poo, M. (2000) Calcium signalling in the guidance of nerve growth by netrin-1. Nature 403, 93-98
7. Tojima, T., Hines, J. H., Henley, J. R., and Kamiguchi, H. (2011) Second messengers and membrane trafficking direct and organize growth cone steering. Nat. Rev. Neurosci. 12,191-203
8. Nicol, X., Hong, K. P., and Spitzer, N. C. (2011) Spatial and temporal second messenger codes for growth cone turning. Proc. Natl. Acad. Sci. U.S.A. 108,13776-13781
9. 2+-de-pendent growth cone guidance. Nat. Neurosci. 9, 1265-1273
10. Wen, Z., Han, L., Bamburg, J. R., Shim, S., Ming, G. L., and Zheng, J. Q. (2007) BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin. J. Cell Biol. 178, 107-119
11. Hines, J. H., Abu-Rub, M., and Henley, J. R. (2010) Asymmetric endocy-tosis and remodeling of β1-integrin adhesions during growth cone chemorepulsion by MAG. Nat. Neurosci. 13, 829-837
12. Myers, J. P., and Gomez, T. M. (2011) Focal adhesion kinase promotes integrin adhesion dynamics necessary for chemotropic turning of nerve growth cones. J. Neurosci. 31, 13585-13595
13. Henle, S. J., Wang, G., Liang, E., Wu, M., Poo, M. M., and Henley, J. R. (2011) Asymmetric PI(3,4,5)P3 and Akt signaling mediates chemotaxis of axonal growth cones. J. Neurosci. 31, 7016-7027
14. Keizer-Gunnink, I., Kortholt, A., and Van Haastert, P. J. (2007) Chemoat-tractants and chemorepellents act by inducing opposite polarity in phos-pholipase C and PI3-kinase signaling. J. Cell Biol. 177, 579-585
15. Iijima, M., and Devreotes, P. (2002) Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109, 599-610
16. Funamoto, S., Meili, R., Lee, S., Parry, L., and Firtel, R. A. (2002) Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 109, 611-623
17. Mukhopadhyay, G., Doherty, P., Walsh, F. S., Crocker, P. R., and Filbin, M. T. (1994) A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron 13, 757-767
18. McKerracher, L., David, S., Jackson, D. L., Kottis, V., Dunn, R. J., and Braun, P. E. (1994) Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth. Neuron 13, 805-811
19. Tang, S., Woodhall, R. W., Shen, Y. J., deBellard, M. E., Saffell, J. L., Do-herty, P., Walsh, F. S., and Filbin, M. T. (1997) Soluble myelin-associated glycoprotein (MAG) found in vivo inhibits axonal regeneration. Mol. Cell Neurosci. 9, 333-346
20. Harel, N. Y., and Strittmatter, S. M. (2006) Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat. Rev. Neurosci. 7, 603- 616
21. Liu, K., Lu, Y., Lee, J. K., Samara, R., Willenberg, R., Sears-Kraxberger, I., Tedeschi, A., Park, K. K., Jin, D., Cai, B., Xu, B., Connolly, L., Steward, O., Zheng, B., and He, Z. (2010) PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat. Neurosci. 13,1075-1081
22. Park, K. K., Liu, K., Hu, Y., Smith, P. D., Wang, C., Cai, B., Xu, B., Connolly, L., Kramvis, I., Sahin, M., and He, Z. (2008) Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science 322,963-966
23. Park, K. K., Liu, K., Hu, Y., Kanter, J. L., and He, Z. (2010) PTEN/mTOR and axon regeneration. Exp. Neurol. 223, 45-50
24. Perdigoto, A. L., Chaudhry, N., Barnes, G. N., Filbin, M. T., and Carter, B. D. (2011) A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons. Mol. Cell Neurosci. 46, 235-244
25. Drinjakovic, J., Jung, H., Campbell, D. S., Strochlic, L., Dwivedy, A., and Holt, C. E. (2010) E3 ligase Nedd4 promotes axon branching bydownregu-lating PTEN. Neuron 65, 341-357
26. Gomez, T. M., Harrigan, D., Henley, J., andRobles, E. (2003) Working with Xenopus spinal neurons in live cell culture. Methods Cell Biol. 71, 129-156
27. 3H]inositol-labeled phosphoi-nositide pools. J. Cell Biol. 143, 501-510
28. Akiyama, H., and Kamiguchi, H. (2010) Phosphatidylinositol 3-kinase facilitates microtubule-dependent membrane transport for neuronal growth cone guidance. J.Biol. Chem. 285, 41740 - 41748
29. Carlstrom, L. P., Hines, J. H., Henle, S. J., and Henley, J. R. (2011) Bidirectional remodeling of β1-integrin adhesions during chemotropic regulation of nerve growth. BMC Biol. 9, 82
30. Song, H., Ming, G., He, Z., Lehmann, M., McKerracher, L., Tessier-Lavi-gne, M., and Poo, M. (1998) Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides. Science 281, 1515-1518
31. Song, H. J., Ming, G. L., and Poo, M. M. (1997) cAMP-induced switching in turning direction of nerve growth cones. Nature 388, 275-279
32. Tamura, M., Gu, J., Matsumoto, K., Aota, S., Parsons, R., and Yamada, K. M. (1998) Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280,1614-1617
33. Gu, J., Tamura, M., and Yamada, K. M. (1998) Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J. Cell Biol. 143, 1375-1383