Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress

Journal of Biological Chemistry

Volumn 285, Issue 17, 2010, Pages 12620-12628

  Maccario, Helene ^a   Perera, Nevin M ^a   Gray, Alexander ^a   Downes, C Peter ^a   Leslie, Nick R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYPEROSMOTIC STRESS; IN-VITRO; NUCLEAR LOCALIZATION; PHOSPHATASE ACTIVITY; PHOSPHATIDYLINOSITOL; PHOSPHOINOSITIDE 3-KINASE; PHOSPHOINOSITIDES; PLASMA MEMBRANES; POLYUBIQUITINATION; PROTEIN LEVEL; REVERSIBLE CONTROL; THREONINE RESIDUES; TUMOR SUPPRESSORS; UBIQUITINATION;

AMINO ACIDS; CELL MEMBRANES; MEMBRANES; PHOSPHORYLATION; PROTEINS;

PHOSPHATASES;

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; OSMOTIC STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; REGULATORY MECHANISM; UBIQUITINATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTIVE TRANSPORT, CELL NUCLEUS; CELL LINE, TUMOR; CELL MEMBRANE; CELL NUCLEUS; HUMANS; OSMOTIC PRESSURE; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHORYLATION; PTEN PHOSPHOHYDROLASE; UBIQUITINATION;

EID: 77951234781     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.072280     Document Type: Article

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