Pten regulates neuronal soma size: A mouse model of Lhermitte-Duclos disease

Nature Genetics

Volumn 29, Issue 4, 2001, Pages 404-411

  Kwon, Chang Hyuk ^a,c   Zhu, Xiaoyan ^a   Zhang, Junyuan ^a   Knoop, Lori L ^a   Tharp, Ruby ^a   Smeyne, Richard J ^a   Eberhart, Charles G ^b   Burger, Peter C ^b   Baker, Suzanne J ^a,c  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SIZE; CLINICAL FEATURE; CONTROLLED STUDY; GENE MUTATION; LETHALITY; LHERMITTE DUCLOS DISEASE; MOUSE; NERVE CELL; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REGULATORY MECHANISM;

ANIMALS; BRAIN; CELL CYCLE PROTEINS; CELL DIVISION; CELL SIZE; CEREBELLAR DISEASES; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DISEASE MODELS, ANIMAL; GENE DELETION; GENES, TUMOR SUPPRESSOR; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOHISTOCHEMISTRY; INTEGRASES; MICE; MICE, TRANSGENIC; NEURONS; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PTEN PHOSPHOHYDROLASE; SEIZURES; TUMOR SUPPRESSOR PROTEINS; VIRAL PROTEINS;

ANIMALIA;

EID: 0035734381     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng781     Document Type: Article

References (50)

1. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate
2. Signalling through phosphoinositide 3-kinases: The lipids take centre stage
3. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
4. Identification of a candidate tumour suppressor gene, MMAC 1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
5. Mutations of the human PTEN gene
6. PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in haematological malignancies
7. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
8. PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome
9. Pten is essential for embryonic development and tumour suppression
10. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
11. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
12. +/− mice
13. +/− mice
14. T cell-specific loss of Pten leads to defects in central and peripheral tolerance
15. Pten and p 27KIP1 cooperate in prostate cancer tumor suppression in the mouse
16. Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice
17. Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice
18. Generalized lacZ expression with the ROSA 26 Cre reporter strain
19. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
20. Granule cells and cerebellar boundaries: Analysis of Unc5h3 mutant chimeras
21. Ablation of NF 1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain
22. Rapid activation of astrocyte-specific expression of GFAP-IacZ transgene by focal injury
23. Changing patterns of gene expression define four stages of cerebellar granule neuron differentiation
24. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
25. PTEN expression is reduced in a subset of sporadic thyroid carcinomas: Evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p 27kip1
26. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3, 4, 5, -trisphosphate and Akt/protein kinase B signaling pathway
27. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN
28. PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2)
29. Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease)
30. Lhermitte-Duclos disease: Literature review and novel treatment strategy
31. Lhermitte-Duclos disease associated with syringomyelia
32. Cowden disease and Lhermitte-Duclos disease: Characterization of a new phakomatosis
33. A heterozygous frameshift mutation of the PTEN/MMAC1 gene in a patient with Lhermitte-Duclos disease-only the mutated allele was expressed in the cerebellar tumor
34. Association of Lhermitte-Duclos and Cowden disease: Report of a new case and review of the literature
35. The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene
36. Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis
37. The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells
38. Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes
39. PTEN/MMAC1/7EP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells
40. PTEN induces G(1) cell cycle arrest and decreases cyclin D 3 levels in endometrial carcinoma cells
41. Cellular survival: A play in three Akts
42. Regulation of neuronal survival by the serine-threonine protein kinase Akt
43. Drosophila PTEN regulates cell growth and proliferation through P13K-dependent and -independent pathways
44. Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/P-3-kinase signaling pathway
45. PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development
46. Genetic control of cell size
47. The conserved phosphoinositide 3-kinase pathway determines heart size in mice
48. Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα
49. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
50. A role for p27/Kip 1 in the control of cerebellar granule cell precursor proliferation