-
1
-
-
13644254794
-
Molecular mechanisms of drug resistance
-
Longley, D. B.; Johnston, P. G. Molecular mechanisms of drug resistance. J. Pathol. 2005, 205, 275-292.
-
(2005)
J. Pathol
, vol.205
, pp. 275-292
-
-
Longley, D.B.1
Johnston, P.G.2
-
2
-
-
0036364467
-
Multidrug resistance in cancer: Role of ATP-dependent transporters
-
Gottesman, M. M.; Fojo, T.; Bates, S. E. Multidrug resistance in cancer: Role of ATP-dependent transporters. Nat. Rev. Cancer 2002, 2, 48-58.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 48-58
-
-
Gottesman, M.M.1
Fojo, T.2
Bates, S.E.3
-
3
-
-
0036074018
-
Mammalian ABC transporters in health and disease
-
Borst, P.; Elferink, R. O. Mammalian ABC transporters in health and disease. Annu. Rev. Biochem. 2002, 71, 537-592.
-
(2002)
Annu. Rev. Biochem
, vol.71
, pp. 537-592
-
-
Borst, P.1
Elferink, R.O.2
-
4
-
-
2342453921
-
Death receptors in chemotherapy and cancer
-
Debatin, K. M.; Krammer, P. H. Death receptors in chemotherapy and cancer. Oncogene 2004, 23, 2950-2966.
-
(2004)
Oncogene
, vol.23
, pp. 2950-2966
-
-
Debatin, K.M.1
Krammer, P.H.2
-
5
-
-
84867878045
-
Cancer stem cell definitions and terminology: The devil is in the details
-
Valent, P.; Bonnet, D.; de Maria, R.; Lapidot, T.; Copland, M.; Melo, J. V.; Chomienne, C.; Ishikawa, F.; Schuringa, J. J.; Stassi, G.; et al. Cancer stem cell definitions and terminology: The devil is in the details. Nat. Rev. Cancer 2012, 12, 767-775.
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 767-775
-
-
Valent, P.1
Bonnet, D.2
de Maria, R.3
Lapidot, T.4
Copland, M.5
Melo, J.V.6
Chomienne, C.7
Ishikawa, F.8
Schuringa, J.J.9
Stassi, G.10
-
6
-
-
9244224723
-
Intrinsic tumour suppression
-
Lowe, S. W.; Cepero, E.; Evan, G. Intrinsic tumour suppression. Nature 2004, 432, 307-315.
-
(2004)
Nature
, vol.432
, pp. 307-315
-
-
Lowe, S.W.1
Cepero, E.2
Evan, G.3
-
7
-
-
38549152194
-
Principles of bioactive lipid signalling: Lessons from sphingolipids
-
Hannun, Y. A.; Obeid, L. M. Principles of bioactive lipid signalling: Lessons from sphingolipids. Nat. Rev. Mol. Cell Biol. 2008, 9, 139-150.
-
(2008)
Nat. Rev. Mol. Cell Biol
, vol.9
, pp. 139-150
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
8
-
-
78751518056
-
Dysregulation of sphingolipid metabolism in cancer
-
Ryland, L. K.; Fox, T. E.; Liu, X.; Loughran, T. P.; Kester, M. Dysregulation of sphingolipid metabolism in cancer. Cancer Biol. Ther. 2011, 11, 138-149.
-
(2011)
Cancer Biol. Ther
, vol.11
, pp. 138-149
-
-
Ryland, L.K.1
Fox, T.E.2
Liu, X.3
Loughran, T.P.4
Kester, M.5
-
9
-
-
0033532912
-
Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)-retinamide in neuroblastoma cell lines
-
Maurer, B. J.; Metelitsa, L. S.; Seeger, R. C.; Cabot, M. C.; Reynolds, C. P. Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)-retinamide in neuroblastoma cell lines. J. Natl. Cancer Inst. 1999, 91, 1138-1146.
-
(1999)
J. Natl. Cancer Inst
, vol.91
, pp. 1138-1146
-
-
Maurer, B.J.1
Metelitsa, L.S.2
Seeger, R.C.3
Cabot, M.C.4
Reynolds, C.P.5
-
10
-
-
0029948396
-
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
-
Cuvillier, O.; Pirianov, G.; Kleuser, B.; Vanek, P. G.; Coso, O. A.; Gutkind, S.; Spiegel, S. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 1996, 381, 800-803.
-
(1996)
Nature
, vol.381
, pp. 800-803
-
-
Cuvillier, O.1
Pirianov, G.2
Kleuser, B.3
Vanek, P.G.4
Coso, O.A.5
Gutkind, S.6
Spiegel, S.7
-
11
-
-
77951898430
-
Glycosynaptic microdomains controlling tumor cell phenotype through alteration of cell growth, adhesion, and motility
-
Hakomori, S. I. Glycosynaptic microdomains controlling tumor cell phenotype through alteration of cell growth, adhesion, and motility. FEBS Lett. 2010, 584, 1901-1906.
-
(2010)
FEBS Lett
, vol.584
, pp. 1901-1906
-
-
Hakomori, S.I.1
-
12
-
-
78049518892
-
An overview of sphingolipid metabolism: From synthesis to breakdown
-
Gault, C. R.; Obeid, L. M.; Hannun, Y. A. An overview of sphingolipid metabolism: From synthesis to breakdown. Adv. Exp. Med. Biol. 2010, 688, 1-23.
-
(2010)
Adv. Exp. Med. Biol
, vol.688
, pp. 1-23
-
-
Gault, C.R.1
Obeid, L.M.2
Hannun, Y.A.3
-
13
-
-
0037518448
-
Salvage pathways in glycosphingolipid metabolism
-
Tettamanti, G.; Bassi, R.; Viani, P.; Riboni, L. Salvage pathways in glycosphingolipid metabolism. Biochimie 2003, 85, 423-437.
-
(2003)
Biochimie
, vol.85
, pp. 423-437
-
-
Tettamanti, G.1
Bassi, R.2
Viani, P.3
Riboni, L.4
-
14
-
-
77953561361
-
Mammalian ceramide synthases
-
Levy, M.; Futerman, A. H. Mammalian ceramide synthases. IUBMB Life 2010, 62, 347-356.
-
(2010)
IUBMB Life
, vol.62
, pp. 347-356
-
-
Levy, M.1
Futerman, A.H.2
-
15
-
-
33748746334
-
When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis
-
Pewzner-Jung, Y.; Ben-Dor, S.; Futerman, A. H. When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis. J. Biol. Chem. 2006, 281, 25001-25005.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 25001-25005
-
-
Pewzner-Jung, Y.1
Ben-Dor, S.2
Futerman, A.H.3
-
16
-
-
0030844101
-
Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum
-
Michel, C.; van Echten-Deckert, G. Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum. FEBS Lett. 1997, 416, 153-155.
-
(1997)
FEBS Lett
, vol.416
, pp. 153-155
-
-
Michel, C.1
van Echten-Deckert, G.2
-
17
-
-
79952706731
-
Ceramide kinase: The first decade
-
Bornancin, F. Ceramide kinase: The first decade. Cell Signal. 2011, 23, 999-1008.
-
(2011)
Cell Signal
, vol.23
, pp. 999-1008
-
-
Bornancin, F.1
-
18
-
-
0842263750
-
Identification of a family of animal sphingomyelin synthases
-
Huitema, K.; van den Dikkenberg, J.; Brouwers, J. F.; Holthuis, J. C. Identification of a family of animal sphingomyelin synthases. EMBO J. 2004, 23, 33-44.
-
(2004)
EMBO J
, vol.23
, pp. 33-44
-
-
Huitema, K.1
van den Dikkenberg, J.2
Brouwers, J.F.3
Holthuis, J.C.4
-
19
-
-
78049498377
-
Sphingolipid transport
-
Riboni, L.; Giussani, P.; Viani, P. Sphingolipid transport. Adv. Exp. Med. Biol. 2010, 688, 24-45.
-
(2010)
Adv. Exp. Med. Biol
, vol.688
, pp. 24-45
-
-
Riboni, L.1
Giussani, P.2
Viani, P.3
-
20
-
-
0026552908
-
Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions
-
Jeckel, D.; Karrenbauer, A.; Burger, K. N.; van Meer, G.; Wieland, F. Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions. J. Cell Biol. 1992, 117, 259-267.
-
(1992)
J. Cell Biol
, vol.117
, pp. 259-267
-
-
Jeckel, D.1
Karrenbauer, A.2
Burger, K.N.3
van Meer, G.4
Wieland, F.5
-
21
-
-
0032080795
-
Glucosylceramide synthase and glycosphingolipid synthesis
-
Ichikawa, S.; Hirabayashi, Y. Glucosylceramide synthase and glycosphingolipid synthesis. Trends Cell Biol. 1998, 8, 198-202.
-
(1998)
Trends Cell Biol
, vol.8
, pp. 198-202
-
-
Ichikawa, S.1
Hirabayashi, Y.2
-
22
-
-
2942639961
-
The cell biology of glycosphingolipids
-
Degroote, S.; Wolthoorn, J.; van Meer, G. The cell biology of glycosphingolipids. Semin. Cell Dev. Biol. 2004, 15, 375-387.
-
(2004)
Semin. Cell Dev. Biol
, vol.15
, pp. 375-387
-
-
Degroote, S.1
Wolthoorn, J.2
van Meer, G.3
-
23
-
-
84855803916
-
Immunology in the clinic review series; focus on cancer: Glycolipids as targets for tumour immunotherapy
-
Durrant, L. G.; Noble, P.; Spendlove, I. Immunology in the clinic review series; focus on cancer: Glycolipids as targets for tumour immunotherapy. Clin. Exp. Immunol. 2012, 167, 206-215.
-
(2012)
Clin. Exp. Immunol
, vol.167
, pp. 206-215
-
-
Durrant, L.G.1
Noble, P.2
Spendlove, I.3
-
24
-
-
3543085572
-
Ganglioside/glycosphingolipid turnover: New concepts
-
Tettamanti, G. Ganglioside/glycosphingolipid turnover: New concepts. Glycoconj. J. 2004, 20, 301-317.
-
(2004)
Glycoconj. J
, vol.20
, pp. 301-317
-
-
Tettamanti, G.1
-
25
-
-
2342430284
-
The plasma membrane-associated sialidase MmNEU3 modifies the ganglioside pattern of adjacent cells supporting its involvement in cell-to-cell interactions
-
Papini, N.; Anastasia, L.; Tringali, C.; Croci, G.; Bresciani, R.; Yamaguchi, K.; Miyagi, T.; Preti, A.; Prinetti, A.; Prioni, S.; et al. The plasma membrane-associated sialidase MmNEU3 modifies the ganglioside pattern of adjacent cells supporting its involvement in cell-to-cell interactions. J. Biol. Chem. 2004, 279, 16989-16995.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 16989-16995
-
-
Papini, N.1
Anastasia, L.2
Tringali, C.3
Croci, G.4
Bresciani, R.5
Yamaguchi, K.6
Miyagi, T.7
Preti, A.8
Prinetti, A.9
Prioni, S.10
-
26
-
-
79851492113
-
New findings on nuclear gangliosides: Overview on metabolism and function
-
Ledeen, R.; Wu, G. New findings on nuclear gangliosides: Overview on metabolism and function. J. Neurochem. 2011, 116, 714-720.
-
(2011)
J. Neurochem
, vol.116
, pp. 714-720
-
-
Ledeen, R.1
Wu, G.2
-
27
-
-
33846443205
-
Role of Neu4L sialidase and its substrate ganglioside GD3 in neuronal apoptosis induced by catechol metabolites
-
Hasegawa, T.; Sugeno, N.; Takeda, A.; Matsuzaki-Kobayashi, M.; Kikuchi, A.; Furukawa, K.; Miyagi, T.; Itoyama, Y. Role of Neu4L sialidase and its substrate ganglioside GD3 in neuronal apoptosis induced by catechol metabolites. FEBS Lett. 2007, 581, 406-412.
-
(2007)
FEBS Lett
, vol.581
, pp. 406-412
-
-
Hasegawa, T.1
Sugeno, N.2
Takeda, A.3
Matsuzaki-Kobayashi, M.4
Kikuchi, A.5
Furukawa, K.6
Miyagi, T.7
Itoyama, Y.8
-
28
-
-
9144268280
-
Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules
-
Tringali, C.; Papini, N.; Fusi, P.; Croci, G.; Borsani, G.; Preti, A.; Tortora, P.; Tettamanti, G.; Venerando, B.; Monti, E. Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules. J. Biol. Chem. 2004, 279, 3169-3179.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 3169-3179
-
-
Tringali, C.1
Papini, N.2
Fusi, P.3
Croci, G.4
Borsani, G.5
Preti, A.6
Tortora, P.7
Tettamanti, G.8
Venerando, B.9
Monti, E.10
-
29
-
-
2342570273
-
Acid and neutral sphingomyelinases: Roles and mechanisms of regulation
-
Marchesini, N.; Hannun, Y. A. Acid and neutral sphingomyelinases: Roles and mechanisms of regulation. Biochem. Cell Biol. 2004, 82, 27-44.
-
(2004)
Biochem. Cell Biol
, vol.82
, pp. 27-44
-
-
Marchesini, N.1
Hannun, Y.A.2
-
30
-
-
0033994563
-
Characterization of sphingomyelinase activity released by thrombin-stimulated platelets
-
Romiti, E.; Vasta, V.; Meacci, E.; Farnararo, M.; Linke, T.; Ferlinz, K.; Sandhoff, K.; Bruni, P. Characterization of sphingomyelinase activity released by thrombin-stimulated platelets. Mol. Cell Biochem. 2000, 205, 75-81.
-
(2000)
Mol. Cell Biochem
, vol.205
, pp. 75-81
-
-
Romiti, E.1
Vasta, V.2
Meacci, E.3
Farnararo, M.4
Linke, T.5
Ferlinz, K.6
Sandhoff, K.7
Bruni, P.8
-
31
-
-
79954509850
-
The neutral sphingomyelinase family: Identifying biochemical connections
-
Clarke, C. J.; Wu, B. X.; Hannun, Y. A. The neutral sphingomyelinase family: Identifying biochemical connections. Adv. Enzyme Regul. 2011, 51, 51-58.
-
(2011)
Adv. Enzyme Regul
, vol.51
, pp. 51-58
-
-
Clarke, C.J.1
Wu, B.X.2
Hannun, Y.A.3
-
32
-
-
33646146401
-
Alkaline sphingomyelinase: An old enzyme with novel implications
-
Duan, R. D. Alkaline sphingomyelinase: An old enzyme with novel implications. Biochim. Biophys. Acta 2006, 1761, 281-291.
-
(2006)
Biochim. Biophys. Acta
, vol.1761
, pp. 281-291
-
-
Duan, R.D.1
-
33
-
-
50049090026
-
Ceramidases: Regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
-
Mao, C.; Obeid, L. M. Ceramidases: Regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochim. Biophys. Acta 2008, 1781, 424-434.
-
(2008)
Biochim. Biophys. Acta
, vol.1781
, pp. 424-434
-
-
Mao, C.1
Obeid, L.M.2
-
34
-
-
0035929560
-
Human acid ceramidase: Processing, glycosylation, and lysosomal targeting
-
Ferlinz, K.; Kopal, G.; Bernardo, K.; Linke, T.; Bar, J.; Breiden, B.; Neumann, U.; Lang, F.; Schuchman, E. H.; Sandhoff, K. Human acid ceramidase: Processing, glycosylation, and lysosomal targeting. J. Biol. Chem. 2001, 276, 35352-35360.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 35352-35360
-
-
Ferlinz, K.1
Kopal, G.2
Bernardo, K.3
Linke, T.4
Bar, J.5
Breiden, B.6
Neumann, U.7
Lang, F.8
Schuchman, E.H.9
Sandhoff, K.10
-
35
-
-
0034618754
-
Neutral/alkaline and acid ceramidase activities are actively released by murine endothelial cells
-
Romiti, E.; Meacci, E.; Tani, M.; Nuti, F.; Farnararo, M.; Ito, M.; Bruni, P. Neutral/alkaline and acid ceramidase activities are actively released by murine endothelial cells. Biochem. Biophys. Res. Commun. 2000, 275, 746-751.
-
(2000)
Biochem. Biophys. Res. Commun
, vol.275
, pp. 746-751
-
-
Romiti, E.1
Meacci, E.2
Tani, M.3
Nuti, F.4
Farnararo, M.5
Ito, M.6
Bruni, P.7
-
36
-
-
17444368619
-
Subcellular localization of human neutral ceramidase expressed in HEK293 cells
-
Hwang, Y. H.; Tani, M.; Nakagawa, T.; Okino, N.; Ito, M. Subcellular localization of human neutral ceramidase expressed in HEK293 cells. Biochem. Biophys. Res. Commun. 2005, 331, 37-42.
-
(2005)
Biochem. Biophys. Res. Commun
, vol.331
, pp. 37-42
-
-
Hwang, Y.H.1
Tani, M.2
Nakagawa, T.3
Okino, N.4
Ito, M.5
-
37
-
-
0035854766
-
Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide
-
Mao, C.; Xu, R.; Szulc, Z. M.; Bielawska, A.; Galadari, S. H.; Obeid, L. M. Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. J. Biol. Chem. 2001, 276, 26577-26588.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 26577-26588
-
-
Mao, C.1
Xu, R.2
Szulc, Z.M.3
Bielawska, A.4
Galadari, S.H.5
Obeid, L.M.6
-
38
-
-
0029670774
-
Topology of glycosphingolipid degradation
-
Sandhoff, K.; Kolter, T. Topology of glycosphingolipid degradation. Trends Cell Biol. 1996, 6, 98-103.
-
(1996)
Trends Cell Biol
, vol.6
, pp. 98-103
-
-
Sandhoff, K.1
Kolter, T.2
-
39
-
-
0034604131
-
Functional characterization of human sphingosine kinase-1
-
Nava, V. E.; Lacana, E.; Poulton, S.; Liu, H.; Sugiura, M.; Kono, K.; Milstien, S.; Kohama, T.; Spiegel, S. Functional characterization of human sphingosine kinase-1. FEBS Lett. 2000, 473, 81-84.
-
(2000)
FEBS Lett
, vol.473
, pp. 81-84
-
-
Nava, V.E.1
Lacana, E.2
Poulton, S.3
Liu, H.4
Sugiura, M.5
Kono, K.6
Milstien, S.7
Kohama, T.8
Spiegel, S.9
-
40
-
-
0036356038
-
Sphingosine kinases: A novel family of lipid kinases
-
Liu, H.; Chakravarty, D.; Maceyka, M.; Milstien, S.; Spiegel, S. Sphingosine kinases: A novel family of lipid kinases. Prog. Nucleic Acid Res. Mol. Biol. 2002, 71, 493-511.
-
(2002)
Prog. Nucleic Acid Res. Mol. Biol
, vol.71
, pp. 493-511
-
-
Liu, H.1
Chakravarty, D.2
Maceyka, M.3
Milstien, S.4
Spiegel, S.5
-
41
-
-
0034733556
-
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform
-
Liu, H.; Sugiura, M.; Nava, V. E.; Edsall, L. C.; Kono, K.; Poulton, S.; Milstien, S.; Kohama, T.; Spiegel, S. Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J. Biol. Chem. 2000, 275, 19513-19520.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 19513-19520
-
-
Liu, H.1
Sugiura, M.2
Nava, V.E.3
Edsall, L.C.4
Kono, K.5
Poulton, S.6
Milstien, S.7
Kohama, T.8
Spiegel, S.9
-
42
-
-
77953771709
-
Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function
-
Serra, M.; Saba, J. D. Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. Adv. Enzyme Regul. 2010, 50, 349-362.
-
(2010)
Adv. Enzyme Regul
, vol.50
, pp. 349-362
-
-
Serra, M.1
Saba, J.D.2
-
43
-
-
0037088581
-
Characterization of murine sphingosine-1-phosphate phosphohydrolase
-
Le Stunff, H.; Peterson, C.; Thornton, R.; Milstien, S.; Mandala, S. M.; Spiegel, S. Characterization of murine sphingosine-1-phosphate phosphohydrolase. J. Biol. Chem. 2002, 277, 8920-8927.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 8920-8927
-
-
Le Stunff, H.1
Peterson, C.2
Thornton, R.3
Milstien, S.4
Mandala, S.M.5
Spiegel, S.6
-
44
-
-
36349003001
-
Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2
-
Le Stunff, H.; Giussani, P.; Maceyka, M.; Lepine, S.; Milstien, S.; Spiegel, S. Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2. J. Biol. Chem. 2007, 282, 34372-34380.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 34372-34380
-
-
Le Stunff, H.1
Giussani, P.2
Maceyka, M.3
Lepine, S.4
Milstien, S.5
Spiegel, S.6
-
45
-
-
56949095716
-
Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease
-
Pyne, S.; Lee, S. C.; Long, J.; Pyne, N. J. Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. Cell Signal. 2009, 21, 14-21.
-
(2009)
Cell Signal
, vol.21
, pp. 14-21
-
-
Pyne, S.1
Lee, S.C.2
Long, J.3
Pyne, N.J.4
-
46
-
-
0033491193
-
CD95(APO-1/Fas)-mediated apoptosis: Live and let die
-
Krammer, P. H. CD95(APO-1/Fas)-mediated apoptosis: Live and let die. Adv. Immunol. 1999, 71, 163-210.
-
(1999)
Adv. Immunol
, vol.71
, pp. 163-210
-
-
Krammer, P.H.1
-
47
-
-
0034536743
-
Regulation of death receptor-mediated apoptosis pathways
-
Schmitz, I.; Kirchhoff, S.; Krammer, P. H. Regulation of death receptor-mediated apoptosis pathways. Int. J. Biochem. Cell Biol. 2000, 32, 1123-1136.
-
(2000)
Int. J. Biochem. Cell Biol
, vol.32
, pp. 1123-1136
-
-
Schmitz, I.1
Kirchhoff, S.2
Krammer, P.H.3
-
48
-
-
17444424930
-
Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
-
Pitti, R. M.; Marsters, S. A.; Lawrence, D. A.; Roy, M.; Kischkel, F. C.; Dowd, P.; Huang, A.; Donahue, C. J.; Sherwood, S. W.; Baldwin, D. T.; et al. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Nature 1998, 396, 699-703.
-
(1998)
Nature
, vol.396
, pp. 699-703
-
-
Pitti, R.M.1
Marsters, S.A.2
Lawrence, D.A.3
Roy, M.4
Kischkel, F.C.5
Dowd, P.6
Huang, A.7
Donahue, C.J.8
Sherwood, S.W.9
Baldwin, D.T.10
-
49
-
-
0033553489
-
A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis
-
Yu, K. Y.; Kwon, B.; Ni, J.; Zhai, Y.; Ebner, R.; Kwon, B. S. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. J. Biol. Chem. 1999, 274, 13733-13736.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 13733-13736
-
-
Yu, K.Y.1
Kwon, B.2
Ni, J.3
Zhai, Y.4
Ebner, R.5
Kwon, B.S.6
-
50
-
-
0036598992
-
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
-
Ashkenazi, A. Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat. Rev. Cancer 2002, 2, 420-430.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 420-430
-
-
Ashkenazi, A.1
-
51
-
-
0033667778
-
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
-
Sprick, M. R.; Weigand, M. A.; Rieser, E.; Rauch, C. T.; Juo, P.; Blenis, J.; Krammer, P. H.; Walczak, H. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity 2000, 12, 599-609.
-
(2000)
Immunity
, vol.12
, pp. 599-609
-
-
Sprick, M.R.1
Weigand, M.A.2
Rieser, E.3
Rauch, C.T.4
Juo, P.5
Blenis, J.6
Krammer, P.H.7
Walczak, H.8
-
52
-
-
0028883850
-
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
-
Kischkel, F. C.; Hellbardt, S.; Behrmann, I.; Germer, M.; Pawlita, M.; Krammer, P. H.; Peter, M. E. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 1995, 14, 5579-5588.
-
(1995)
EMBO J
, vol.14
, pp. 5579-5588
-
-
Kischkel, F.C.1
Hellbardt, S.2
Behrmann, I.3
Germer, M.4
Pawlita, M.5
Krammer, P.H.6
Peter, M.E.7
-
53
-
-
0035229427
-
The mitochondrion in apoptosis: How Pandora's box opens
-
Zamzami, N.; Kroemer, G. The mitochondrion in apoptosis: How Pandora's box opens. Nat. Rev. Mol. Cell Biol. 2001, 2, 67-71.
-
(2001)
Nat. Rev. Mol. Cell Biol
, vol.2
, pp. 67-71
-
-
Zamzami, N.1
Kroemer, G.2
-
55
-
-
0033009890
-
The central effectors of cell death in the immune system
-
Rathmell, J. C.; Thompson, C. B. The central effectors of cell death in the immune system. Annu. Rev. Immunol. 1999, 17, 781-828.
-
(1999)
Annu. Rev. Immunol
, vol.17
, pp. 781-828
-
-
Rathmell, J.C.1
Thompson, C.B.2
-
56
-
-
0035265686
-
PUMA, a novel proapoptotic gene, is induced by p53
-
Nakano, K.; Vousden, K. H. PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 2001, 7, 683-694.
-
(2001)
Mol. Cell
, vol.7
, pp. 683-694
-
-
Nakano, K.1
Vousden, K.H.2
-
57
-
-
0034664733
-
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
-
Oda, K.; Arakawa, H.; Tanaka, T.; Matsuda, K.; Tanikawa, C.; Mori, T.; Nishimori, H.; Tamai, K.; Tokino, T.; Nakamura, Y.; et al. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 2000, 102, 849-862.
-
(2000)
Cell
, vol.102
, pp. 849-862
-
-
Oda, K.1
Arakawa, H.2
Tanaka, T.3
Matsuda, K.4
Tanikawa, C.5
Mori, T.6
Nishimori, H.7
Tamai, K.8
Tokino, T.9
Nakamura, Y.10
-
58
-
-
0031743648
-
p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs
-
Muller, M.; Wilder, S.; Bannasch, D.; Israeli, D.; Lehlbach, K.; Li-Weber, M.; Friedman, S. L.; Galle, P. R.; Stremmel, W.; Oren, M.; et al. p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J. Exp. Med. 1998, 188, 2033-2045.
-
(1998)
J. Exp. Med
, vol.188
, pp. 2033-2045
-
-
Muller, M.1
Wilder, S.2
Bannasch, D.3
Israeli, D.4
Lehlbach, K.5
Li-Weber, M.6
Friedman, S.L.7
Galle, P.R.8
Stremmel, W.9
Oren, M.10
-
59
-
-
0031253977
-
KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene
-
Wu, G. S.; Burns, T. F.; McDonald, E. R., 3rd; Jiang, W.; Meng, R.; Krantz, I. D.; Kao, G.; Gan, D. D.; Zhou, J. Y.; Muschel, R.; et al. KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nat. Genet. 1997, 17, 141-143.
-
(1997)
Nat. Genet
, vol.17
, pp. 141-143
-
-
Wu, G.S.1
Burns, T.F.2
McDonald III, E.R.3
Jiang, W.4
Meng, R.5
Krantz, I.D.6
Kao, G.7
Gan, D.D.8
Zhou, J.Y.9
Muschel, R.10
-
60
-
-
0036547417
-
Death and anti-death: Tumour resistance to apoptosis
-
Igney, F. H.; Krammer, P. H. Death and anti-death: Tumour resistance to apoptosis. Nat. Rev. Cancer 2002, 2, 277-288.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 277-288
-
-
Igney, F.H.1
Krammer, P.H.2
-
61
-
-
84884535896
-
Cancer drug resistance: An evolving paradigm
-
Holohan, C.; van Schaeybroeck, S.; Longley, D. B.; Johnston, P. G. Cancer drug resistance: An evolving paradigm. Nat. Rev. Cancer 2013, 13, 714-726.
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 714-726
-
-
Holohan, C.1
van Schaeybroeck, S.2
Longley, D.B.3
Johnston, P.G.4
-
62
-
-
77949957365
-
Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents
-
Sharma, S. V.; Haber, D. A.; Settleman, J. Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents. Nat. Rev. Cancer 2010, 10, 241-253.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 241-253
-
-
Sharma, S.V.1
Haber, D.A.2
Settleman, J.3
-
63
-
-
0032752063
-
Cellular survival: A play in three Akts
-
Datta, S. R.; Brunet, A.; Greenberg, M. E. Cellular survival: A play in three Akts. Genes Dev. 1999, 13, 2905-2927.
-
(1999)
Genes Dev
, vol.13
, pp. 2905-2927
-
-
Datta, S.R.1
Brunet, A.2
Greenberg, M.E.3
-
65
-
-
0035525733
-
Cellular stress response and apoptosis in cancer therapy
-
Herr, I.; Debatin, K. M. Cellular stress response and apoptosis in cancer therapy. Blood 2001, 98, 2603-2614.
-
(2001)
Blood
, vol.98
, pp. 2603-2614
-
-
Herr, I.1
Debatin, K.M.2
-
66
-
-
0030448021
-
Functions of ceramide in coordinating cellular responses to stress
-
Hannun, Y. A. Functions of ceramide in coordinating cellular responses to stress. Science 1996, 274, 1855-1859.
-
(1996)
Science
, vol.274
, pp. 1855-1859
-
-
Hannun, Y.A.1
-
67
-
-
0037135626
-
The Ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind
-
Hannun, Y. A.; Obeid, L. M. The Ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind. J. Biol. Chem. 2002, 277, 25847-25850.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 25847-25850
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
68
-
-
3543114272
-
Biologically active sphingolipids in cancer pathogenesis and treatment
-
Ogretmen, B.; Hannun, Y. A. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat. Rev. Cancer 2004, 4, 604-616.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 604-616
-
-
Ogretmen, B.1
Hannun, Y.A.2
-
70
-
-
1542358155
-
Ceramide synthesis and metabolism as a target for cancer therapy
-
Reynolds, C. P.; Maurer, B. J.; Kolesnick, R. N. Ceramide synthesis and metabolism as a target for cancer therapy. Cancer Lett. 2004, 206, 169-180.
-
(2004)
Cancer Lett
, vol.206
, pp. 169-180
-
-
Reynolds, C.P.1
Maurer, B.J.2
Kolesnick, R.N.3
-
71
-
-
84871720518
-
Ceramide-orchestrated signalling in cancer cells
-
Morad, S. A.; Cabot, M. C. Ceramide-orchestrated signalling in cancer cells. Nat. Rev. Cancer 2013, 13, 51-65.
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 51-65
-
-
Morad, S.A.1
Cabot, M.C.2
-
72
-
-
0029148660
-
Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
-
Bose, R.; Verheij, M.; Haimovitz-Friedman, A.; Scotto, K.; Fuks, Z.; Kolesnick, R. Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals. Cell 1995, 82, 405-414.
-
(1995)
Cell
, vol.82
, pp. 405-414
-
-
Bose, R.1
Verheij, M.2
Haimovitz-Friedman, A.3
Scotto, K.4
Fuks, Z.5
Kolesnick, R.6
-
73
-
-
0036534724
-
De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis
-
Gomez del Pulgar, T.; Velasco, G.; Sanchez, C.; Haro, A.; Guzman, M. De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis. Biochem. J. 2002, 363, 183-188.
-
(2002)
Biochem. J
, vol.363
, pp. 183-188
-
-
Gomez del Pulgar, T.1
Velasco, G.2
Sanchez, C.3
Haro, A.4
Guzman, M.5
-
74
-
-
0034708594
-
Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis
-
Perry, D. K.; Carton, J.; Shah, A. K.; Meredith, F.; Uhlinger, D. J.; Hannun, Y. A. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J. Biol. Chem. 2000, 275, 9078-9084.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 9078-9084
-
-
Perry, D.K.1
Carton, J.2
Shah, A.K.3
Meredith, F.4
Uhlinger, D.J.5
Hannun, Y.A.6
-
75
-
-
0035977067
-
FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1
-
Chalfant, C. E.; Ogretmen, B.; Galadari, S.; Kroesen, B. J.; Pettus, B. J.; Hannun, Y. A. FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1. J. Biol. Chem. 2001, 276, 44848-44855.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 44848-44855
-
-
Chalfant, C.E.1
Ogretmen, B.2
Galadari, S.3
Kroesen, B.J.4
Pettus, B.J.5
Hannun, Y.A.6
-
76
-
-
18644379261
-
Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase
-
Luberto, C.; Hassler, D. F.; Signorelli, P.; Okamoto, Y.; Sawai, H.; Boros, E.; Hazen-Martin, D. J.; Obeid, L. M.; Hannun, Y. A.; Smith, G. K. Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. J. Biol. Chem. 2002, 277, 41128-41139.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 41128-41139
-
-
Luberto, C.1
Hassler, D.F.2
Signorelli, P.3
Okamoto, Y.4
Sawai, H.5
Boros, E.6
Hazen-Martin, D.J.7
Obeid, L.M.8
Hannun, Y.A.9
Smith, G.K.10
-
77
-
-
0033662390
-
Activation of neutral sphingomyelinase participates in ethanol-induced apoptosis in Hep G2 cells
-
Liu, J. J.; Wang, J. Y.; Hertervig, E.; Cheng, Y.; Nilsson, A.; Duan, R. D. Activation of neutral sphingomyelinase participates in ethanol-induced apoptosis in Hep G2 cells. Alcohol. Alcohol. 2000, 35, 569-573.
-
(2000)
Alcohol. Alcohol
, vol.35
, pp. 569-573
-
-
Liu, J.J.1
Wang, J.Y.2
Hertervig, E.3
Cheng, Y.4
Nilsson, A.5
Duan, R.D.6
-
78
-
-
84873447695
-
The nonlysosomal β-glucosidase GBA2 promotes endoplasmic reticulum stress and impairs tumorigenicity of human melanoma cells
-
Sorli, S. C.; Colie, S.; Albinet, V.; Dubrac, A.; Touriol, C.; Guilbaud, N.; Bedia, C.; Fabrias, G.; Casas, J.; Segui, B.; et al. The nonlysosomal β-glucosidase GBA2 promotes endoplasmic reticulum stress and impairs tumorigenicity of human melanoma cells. FASEB J. 2013, 27, 489-498.
-
(2013)
FASEB J
, vol.27
, pp. 489-498
-
-
Sorli, S.C.1
Colie, S.2
Albinet, V.3
Dubrac, A.4
Touriol, C.5
Guilbaud, N.6
Bedia, C.7
Fabrias, G.8
Casas, J.9
Segui, B.10
-
79
-
-
0035079539
-
Ceramide glycosylation potentiates cellular multidrug resistance
-
Liu, Y. Y.; Han, T. Y.; Giuliano, A. E.; Cabot, M. C. Ceramide glycosylation potentiates cellular multidrug resistance. FASEB J. 2001, 15, 719-730.
-
(2001)
FASEB J
, vol.15
, pp. 719-730
-
-
Liu, Y.Y.1
Han, T.Y.2
Giuliano, A.E.3
Cabot, M.C.4
-
80
-
-
2342437213
-
Sphingolipid metabolism enzymes as targets for anticancer therapy
-
Kok, J. W.; Sietsma, H. Sphingolipid metabolism enzymes as targets for anticancer therapy. Curr. Drug Targets 2004, 5, 375-382.
-
(2004)
Curr. Drug Targets
, vol.5
, pp. 375-382
-
-
Kok, J.W.1
Sietsma, H.2
-
81
-
-
84855837829
-
Glucosylceramide synthase protects glioblastoma cells against autophagic and apoptotic death induced by temozolomide and Paclitaxel
-
Giussani, P.; Bassi, R.; Anelli, V.; Brioschi, L.; de Zen, F.; Riccitelli, E.; Caroli, M.; Campanella, R.; Gaini, S. M.; Viani, P.; et al. Glucosylceramide synthase protects glioblastoma cells against autophagic and apoptotic death induced by temozolomide and Paclitaxel. Cancer Investig. 2012, 30, 27-37.
-
(2012)
Cancer Investig
, vol.30
, pp. 27-37
-
-
Giussani, P.1
Bassi, R.2
Anelli, V.3
Brioschi, L.4
de Zen, F.5
Riccitelli, E.6
Caroli, M.7
Campanella, R.8
Gaini, S.M.9
Viani, P.10
-
82
-
-
0035819885
-
Targeting ceramide metabolism-A strategy for overcoming drug resistance
-
Senchenkov, A.; Litvak, D. A.; Cabot, M. C. Targeting ceramide metabolism-A strategy for overcoming drug resistance. J. Natl. Cancer Inst. 2001, 93, 347-357.
-
(2001)
J. Natl. Cancer Inst
, vol.93
, pp. 347-357
-
-
Senchenkov, A.1
Litvak, D.A.2
Cabot, M.C.3
-
83
-
-
2442620446
-
Cytoprotective effect of glucosylceramide synthase inhibition against daunorubicin-induced apoptosis in human leukemic cell lines
-
Grazide, S.; Terrisse, A. D.; Lerouge, S.; Laurent, G.; Jaffrezou, J. P. Cytoprotective effect of glucosylceramide synthase inhibition against daunorubicin-induced apoptosis in human leukemic cell lines. J. Biol. Chem. 2004, 279, 18256-18261.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 18256-18261
-
-
Grazide, S.1
Terrisse, A.D.2
Lerouge, S.3
Laurent, G.4
Jaffrezou, J.P.5
-
84
-
-
84896692542
-
Galactosylceramide affects tumorigenic and metastatic properties of breast cancer cells as an anti-apoptotic molecule
-
Owczarek, T. B.; Suchanski, J.; Pula, B.; Kmiecik, A. M.; Chadalski, M.; Jethon, A.; Dziegiel, P.; Ugorski, M. Galactosylceramide affects tumorigenic and metastatic properties of breast cancer cells as an anti-apoptotic molecule. PLoS One 2013, 8, e84191.
-
(2013)
PLoS One
, vol.8
-
-
Owczarek, T.B.1
Suchanski, J.2
Pula, B.3
Kmiecik, A.M.4
Chadalski, M.5
Jethon, A.6
Dziegiel, P.7
Ugorski, M.8
-
85
-
-
12244284610
-
Possible role of ceramide as an indicator of chemoresistance: Decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia
-
Itoh, M.; Kitano, T.; Watanabe, M.; Kondo, T.; Yabu, T.; Taguchi, Y.; Iwai, K.; Tashima, M.; Uchiyama, T.; Okazaki, T. Possible role of ceramide as an indicator of chemoresistance: Decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia. Clin. Cancer Res. 2003, 9, 415-423.
-
(2003)
Clin. Cancer Res
, vol.9
, pp. 415-423
-
-
Itoh, M.1
Kitano, T.2
Watanabe, M.3
Kondo, T.4
Yabu, T.5
Taguchi, Y.6
Iwai, K.7
Tashima, M.8
Uchiyama, T.9
Okazaki, T.10
-
86
-
-
77949541016
-
Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death
-
Lafont, E.; Milhas, D.; Carpentier, S.; Garcia, V.; Jin, Z. X.; Umehara, H.; Okazaki, T.; Schulze-Osthoff, K.; Levade, T.; Benoist, H.; et al. Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death. Cell Death Differ. 2010, 17, 642-654.
-
(2010)
Cell Death Differ
, vol.17
, pp. 642-654
-
-
Lafont, E.1
Milhas, D.2
Carpentier, S.3
Garcia, V.4
Jin, Z.X.5
Umehara, H.6
Okazaki, T.7
Schulze-Osthoff, K.8
Levade, T.9
Benoist, H.10
-
87
-
-
34248216667
-
Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage
-
Separovic, D.; Hanada, K.; Maitah, M. Y.; Nagy, B.; Hang, I.; Tainsky, M. A.; Kraniak, J. M.; Bielawski, J. Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage. Biochem. Biophys. Res. Commun. 2007, 358, 196-202.
-
(2007)
Biochem. Biophys. Res. Commun
, vol.358
, pp. 196-202
-
-
Separovic, D.1
Hanada, K.2
Maitah, M.Y.3
Nagy, B.4
Hang, I.5
Tainsky, M.A.6
Kraniak, J.M.7
Bielawski, J.8
-
88
-
-
2542501763
-
De novo ceramide accumulation due to inhibition of its conversion to complex sphingolipids in apoptotic photosensitized cells
-
Dolgachev, V.; Farooqui, M. S.; Kulaeva, O. I.; Tainsky, M. A.; Nagy, B.; Hanada, K.; Separovic, D. De novo ceramide accumulation due to inhibition of its conversion to complex sphingolipids in apoptotic photosensitized cells. J. Biol. Chem. 2004, 279, 23238-23249.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 23238-23249
-
-
Dolgachev, V.1
Farooqui, M.S.2
Kulaeva, O.I.3
Tainsky, M.A.4
Nagy, B.5
Hanada, K.6
Separovic, D.7
-
89
-
-
80054080467
-
Ceramide-based therapeutics for the treatment of cancer
-
Barth, B. M.; Cabot, M. C.; Kester, M. Ceramide-based therapeutics for the treatment of cancer. Anti-Cancer Agents Med. Chem. 2011, 11, 911-919.
-
(2011)
Anti-Cancer Agents Med. Chem
, vol.11
, pp. 911-919
-
-
Barth, B.M.1
Cabot, M.C.2
Kester, M.3
-
90
-
-
0347611095
-
Molecular machinery for non-vesicular trafficking of ceramide
-
Hanada, K.; Kumagai, K.; Yasuda, S.; Miura, Y.; Kawano, M.; Fukasawa, M.; Nishijima, M. Molecular machinery for non-vesicular trafficking of ceramide. Nature 2003, 426, 803-809.
-
(2003)
Nature
, vol.426
, pp. 803-809
-
-
Hanada, K.1
Kumagai, K.2
Yasuda, S.3
Miura, Y.4
Kawano, M.5
Fukasawa, M.6
Nishijima, M.7
-
91
-
-
34249828179
-
Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs
-
Swanton, C.; Marani, M.; Pardo, O.; Warne, P. H.; Kelly, G.; Sahai, E.; Elustondo, F.; Chang, J.; Temple, J.; Ahmed, A. A.; et al. Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Cancer Cell 2007, 11, 498-512.
-
(2007)
Cancer Cell
, vol.11
, pp. 498-512
-
-
Swanton, C.1
Marani, M.2
Pardo, O.3
Warne, P.H.4
Kelly, G.5
Sahai, E.6
Elustondo, F.7
Chang, J.8
Temple, J.9
Ahmed, A.A.10
-
92
-
-
84856039513
-
CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction
-
Lee, A. J.; Roylance, R.; Sander, J.; Gorman, P.; Endesfelder, D.; Kschischo, M.; Jones, N. P.; East, P.; Nicke, B.; Spassieva, S.; et al. CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction. J. Pathol. 2012, 226, 482-494.
-
(2012)
J. Pathol
, vol.226
, pp. 482-494
-
-
Lee, A.J.1
Roylance, R.2
Sander, J.3
Gorman, P.4
Endesfelder, D.5
Kschischo, M.6
Jones, N.P.7
East, P.8
Nicke, B.9
Spassieva, S.10
-
93
-
-
84861881638
-
Loss of the ceramide transfer protein augments EGF receptor signaling in breast cancer
-
Heering, J.; Weis, N.; Holeiter, M.; Neugart, F.; Staebler, A.; Fehm, T. N.; Bischoff, A.; Schiller, J.; Duss, S.; Schmid, S.; et al. Loss of the ceramide transfer protein augments EGF receptor signaling in breast cancer. Cancer Res. 2012, 72, 2855-2866.
-
(2012)
Cancer Res
, vol.72
, pp. 2855-2866
-
-
Heering, J.1
Weis, N.2
Holeiter, M.3
Neugart, F.4
Staebler, A.5
Fehm, T.N.6
Bischoff, A.7
Schiller, J.8
Duss, S.9
Schmid, S.10
-
94
-
-
35048824758
-
Sphingolipid signaling pathways as potential therapeutic targets in gliomas
-
Van Brocklyn, J. R. Sphingolipid signaling pathways as potential therapeutic targets in gliomas. Mini Rev. Med. Chem. 2007, 7, 984-990.
-
(2007)
Mini Rev. Med. Chem
, vol.7
, pp. 984-990
-
-
Van Brocklyn, J.R.1
-
95
-
-
21644478540
-
Ceramide triggers caspase activation during gamma-radiation-induced apoptosis of human glioma cells lacking functional p53
-
Hara, S.; Nakashima, S.; Kiyono, T.; Sawada, M.; Yoshimura, S.; Iwama, T.; Sakai, N. Ceramide triggers caspase activation during gamma-radiation-induced apoptosis of human glioma cells lacking functional p53. Oncol. Rep. 2004, 12, 119-123.
-
(2004)
Oncol. Rep
, vol.12
, pp. 119-123
-
-
Hara, S.1
Nakashima, S.2
Kiyono, T.3
Sawada, M.4
Yoshimura, S.5
Iwama, T.6
Sakai, N.7
-
96
-
-
4344606268
-
p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis
-
Hara, S.; Nakashima, S.; Kiyono, T.; Sawada, M.; Yoshimura, S.; Iwama, T.; Banno, Y.; Shinoda, J.; Sakai, N. p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis. Cell Death Differ. 2004, 11, 853-861.
-
(2004)
Cell Death Differ
, vol.11
, pp. 853-861
-
-
Hara, S.1
Nakashima, S.2
Kiyono, T.3
Sawada, M.4
Yoshimura, S.5
Iwama, T.6
Banno, Y.7
Shinoda, J.8
Sakai, N.9
-
97
-
-
23044517184
-
Cannabinoids and ceramide: Two lipids acting hand-by-hand
-
Velasco, G.; Galve-Roperh, I.; Sanchez, C.; Blazquez, C.; Haro, A.; Guzman, M. Cannabinoids and ceramide: Two lipids acting hand-by-hand. Life Sci. 2005, 77, 1723-1731.
-
(2005)
Life Sci
, vol.77
, pp. 1723-1731
-
-
Velasco, G.1
Galve-Roperh, I.2
Sanchez, C.3
Blazquez, C.4
Haro, A.5
Guzman, M.6
-
98
-
-
0038322046
-
Ceramide in nitric oxide inhibition of glioma cell growth. Evidence for the involvement of ceramide traffic
-
Viani, P.; Giussani, P.; Brioschi, L.; Bassi, R.; Anelli, V.; Tettamanti, G.; Riboni, L. Ceramide in nitric oxide inhibition of glioma cell growth. Evidence for the involvement of ceramide traffic. J. Biol. Chem. 2003, 278, 9592-9601.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 9592-9601
-
-
Viani, P.1
Giussani, P.2
Brioschi, L.3
Bassi, R.4
Anelli, V.5
Tettamanti, G.6
Riboni, L.7
-
99
-
-
84877109360
-
Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway
-
Gramatzki, D.; Herrmann, C.; Happold, C.; Becker, K. A.; Gulbins, E.; Weller, M.; Tabatabai, G. Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway. PLoS One 2013, 8, e63527.
-
(2013)
PLoS One
, vol.8
-
-
Gramatzki, D.1
Herrmann, C.2
Happold, C.3
Becker, K.A.4
Gulbins, E.5
Weller, M.6
Tabatabai, G.7
-
100
-
-
83755172971
-
Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy
-
Barcelo-Coblijn, G.; Martin, M. L.; de Almeida, R. F.; Noguera-Salva, M. A.; Marcilla-Etxenike, A.; Guardiola-Serrano, F.; Luth, A.; Kleuser, B.; Halver, J. E.; Escriba, P. V. Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy. Proc. Natl. Acad. Sci. USA 2011, 108, 19569-19574.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 19569-19574
-
-
Barcelo-Coblijn, G.1
Martin, M.L.2
de Almeida, R.F.3
Noguera-Salva, M.A.4
Marcilla-Etxenike, A.5
Guardiola-Serrano, F.6
Luth, A.7
Kleuser, B.8
Halver, J.E.9
Escriba, P.V.10
-
101
-
-
39049169151
-
Ceramide traffic in C6 glioma cells: Evidence for CERT-dependent and independent transport from ER to the Golgi apparatus
-
Giussani, P.; Colleoni, T.; Brioschi, L.; Bassi, R.; Hanada, K.; Tettamanti, G.; Riboni, L.; Viani, P. Ceramide traffic in C6 glioma cells: Evidence for CERT-dependent and independent transport from ER to the Golgi apparatus. Biochim. Biophys. Acta 2008, 1781, 40-51.
-
(2008)
Biochim. Biophys. Acta
, vol.1781
, pp. 40-51
-
-
Giussani, P.1
Colleoni, T.2
Brioschi, L.3
Bassi, R.4
Hanada, K.5
Tettamanti, G.6
Riboni, L.7
Viani, P.8
-
102
-
-
33745442062
-
Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide
-
Giussani, P.; Maceyka, M.; le Stunff, H.; Mikami, A.; Lepine, S.; Wang, E.; Kelly, S.; Merrill, A. H., Jr.; Milstien, S.; Spiegel, S. Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. Mol. Cell. Biol. 2006, 26, 5055-5069.
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 5055-5069
-
-
Giussani, P.1
Maceyka, M.2
le Stunff, H.3
Mikami, A.4
Lepine, S.5
Wang, E.6
Kelly, S.7
Merrill Jr., A.H.8
Milstien, S.9
Spiegel, S.10
-
103
-
-
84868524114
-
Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival
-
Veret, J.; Coant, N.; Gorshkova, I. A.; Giussani, P.; Fradet, M.; Riccitelli, E.; Skobeleva, A.; Goya, J.; Kassis, N.; Natarajan, V.; et al. Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival. Biochim. Biophys. Acta 2013, 1831, 251-262.
-
(2013)
Biochim. Biophys. Acta
, vol.1831
, pp. 251-262
-
-
Veret, J.1
Coant, N.2
Gorshkova, I.A.3
Giussani, P.4
Fradet, M.5
Riccitelli, E.6
Skobeleva, A.7
Goya, J.8
Kassis, N.9
Natarajan, V.10
-
104
-
-
84881479778
-
Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: Novel therapeutic agents and advances in understanding
-
Sami, A.; Karsy, M. Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: Novel therapeutic agents and advances in understanding. Tumour Biol. 2013, 34, 1991-2002.
-
(2013)
Tumour Biol
, vol.34
, pp. 1991-2002
-
-
Sami, A.1
Karsy, M.2
-
105
-
-
64149127609
-
Phosphatidylinositol 3-kinase/AKT pathway regulates the endoplasmic reticulum to golgi traffic of ceramide in glioma cells: A link between lipid signaling pathways involved in the control of cell survival
-
Giussani, P.; Brioschi, L.; Bassi, R.; Riboni, L.; Viani, P. Phosphatidylinositol 3-kinase/AKT pathway regulates the endoplasmic reticulum to golgi traffic of ceramide in glioma cells: A link between lipid signaling pathways involved in the control of cell survival. J. Biol. Chem. 2009, 284, 5088-5096.
-
(2009)
J. Biol. Chem
, vol.284
, pp. 5088-5096
-
-
Giussani, P.1
Brioschi, L.2
Bassi, R.3
Riboni, L.4
Viani, P.5
-
107
-
-
0028934811
-
Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest
-
Dbaibo, G. S.; Pushkareva, M. Y.; Jayadev, S.; Schwarz, J. K.; Horowitz, J. M.; Obeid, L. M.; Hannun, Y. A. Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc. Natl. Acad. Sci. USA 1995, 92, 1347-1351.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 1347-1351
-
-
Dbaibo, G.S.1
Pushkareva, M.Y.2
Jayadev, S.3
Schwarz, J.K.4
Horowitz, J.M.5
Obeid, L.M.6
Hannun, Y.A.7
-
108
-
-
0037066727
-
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1
-
Chalfant, C. E.; Rathman, K.; Pinkerman, R. L.; Wood, R. E.; Obeid, L. M.; Ogretmen, B.; Hannun, Y. A. De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J. Biol. Chem. 2002, 277, 12587-12595.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 12587-12595
-
-
Chalfant, C.E.1
Rathman, K.2
Pinkerman, R.L.3
Wood, R.E.4
Obeid, L.M.5
Ogretmen, B.6
Hannun, Y.A.7
-
109
-
-
0033575320
-
Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A
-
Ruvolo, P. P.; Deng, X.; Ito, T.; Carr, B. K.; May, W. S. Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. J. Biol. Chem. 1999, 274, 20296-20300.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 20296-20300
-
-
Ruvolo, P.P.1
Deng, X.2
Ito, T.3
Carr, B.K.4
May, W.S.5
-
110
-
-
84871250128
-
Sphingolipids: Regulators of crosstalk between apoptosis and autophagy
-
Young, M. M.; Kester, M.; Wang, H. G. Sphingolipids: Regulators of crosstalk between apoptosis and autophagy. J. Lipid Res. 2013, 54, 5-19.
-
(2013)
J. Lipid Res
, vol.54
, pp. 5-19
-
-
Young, M.M.1
Kester, M.2
Wang, H.G.3
-
111
-
-
0033787676
-
Biomodulatory role of ceramide in basic fibroblast growth factor-induced proliferation of cerebellar astrocytes in primary culture
-
Riboni, L.; Viani, P.; Bassi, R.; Stabilini, A.; Tettamanti, G. Biomodulatory role of ceramide in basic fibroblast growth factor-induced proliferation of cerebellar astrocytes in primary culture. Glia 2000, 32, 137-145.
-
(2000)
Glia
, vol.32
, pp. 137-145
-
-
Riboni, L.1
Viani, P.2
Bassi, R.3
Stabilini, A.4
Tettamanti, G.5
-
112
-
-
34248563290
-
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1-to S-phase transition
-
Meloche, S.; Pouyssegur, J. The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1-to S-phase transition. Oncogene 2007, 26, 3227-3239.
-
(2007)
Oncogene
, vol.26
, pp. 3227-3239
-
-
Meloche, S.1
Pouyssegur, J.2
-
113
-
-
65949119310
-
How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?
-
Mebratu, Y.; Tesfaigzi, Y. How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer? Cell Cycle 2009, 8, 1168-1175.
-
(2009)
Cell Cycle
, vol.8
, pp. 1168-1175
-
-
Mebratu, Y.1
Tesfaigzi, Y.2
-
114
-
-
1542723736
-
The structural requirements for ceramide activation of serine-threonine protein phosphatases
-
Chalfant, C. E.; Szulc, Z.; Roddy, P.; Bielawska, A.; Hannun, Y. A. The structural requirements for ceramide activation of serine-threonine protein phosphatases. J. Lipid Res. 2004, 45, 496-506.
-
(2004)
J. Lipid Res
, vol.45
, pp. 496-506
-
-
Chalfant, C.E.1
Szulc, Z.2
Roddy, P.3
Bielawska, A.4
Hannun, Y.A.5
-
115
-
-
33846618797
-
Identification of proteins interacting with the catalytic subunit of PP2A by proteomics
-
Lee, W. J.; Kim, D. U.; Lee, M. Y.; Choi, K. Y. Identification of proteins interacting with the catalytic subunit of PP2A by proteomics. Proteomics 2007, 7, 206-214.
-
(2007)
Proteomics
, vol.7
, pp. 206-214
-
-
Lee, W.J.1
Kim, D.U.2
Lee, M.Y.3
Choi, K.Y.4
-
116
-
-
30044452600
-
Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes
-
Adams, D. G.; Coffee, R. L., Jr.; Zhang, H.; Pelech, S.; Strack, S.; Wadzinski, B. E. Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes. J. Biol. Chem. 2005, 280, 42644-42654.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 42644-42654
-
-
Adams, D.G.1
Coffee Jr., R.L.2
Zhang, H.3
Pelech, S.4
Strack, S.5
Wadzinski, B.E.6
-
117
-
-
34548329395
-
The metabolism and function of sphingolipids and glycosphingolipids
-
Lahiri, S.; Futerman, A. H. The metabolism and function of sphingolipids and glycosphingolipids. Cell. Mol. Life Sci. 2007, 64, 2270-2284.
-
(2007)
Cell. Mol. Life Sci
, vol.64
, pp. 2270-2284
-
-
Lahiri, S.1
Futerman, A.H.2
-
118
-
-
29144469318
-
Ceramide-enriched membrane domains
-
Bollinger, C. R.; Teichgraber, V.; Gulbins, E. Ceramide-enriched membrane domains. Biochim. Biophys. Acta 2005, 1746, 284-294.
-
(2005)
Biochim. Biophys. Acta
, vol.1746
, pp. 284-294
-
-
Bollinger, C.R.1
Teichgraber, V.2
Gulbins, E.3
-
119
-
-
0042335762
-
Ceramide-mediated clustering is required for CD95-DISC formation
-
Grassme, H.; Cremesti, A.; Kolesnick, R.; Gulbins, E. Ceramide-mediated clustering is required for CD95-DISC formation. Oncogene 2003, 22, 5457-5470.
-
(2003)
Oncogene
, vol.22
, pp. 5457-5470
-
-
Grassme, H.1
Cremesti, A.2
Kolesnick, R.3
Gulbins, E.4
-
120
-
-
0035850716
-
Mitochondrial lipid alterations during Fas-and radiation-induced apoptosis
-
Matsko, C. M.; Hunter, O. C.; Rabinowich, H.; Lotze, M. T.; Amoscato, A. A. Mitochondrial lipid alterations during Fas-and radiation-induced apoptosis. Biochem. Biophys. Res. Commun. 2001, 287, 1112-1120.
-
(2001)
Biochem. Biophys. Res. Commun
, vol.287
, pp. 1112-1120
-
-
Matsko, C.M.1
Hunter, O.C.2
Rabinowich, H.3
Lotze, M.T.4
Amoscato, A.A.5
-
121
-
-
0035199418
-
Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis
-
Birbes, H.; El Bawab, S.; Hannun, Y. A.; Obeid, L. M. Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. FASEB J. 2001, 15, 2669-2679.
-
(2001)
FASEB J
, vol.15
, pp. 2669-2679
-
-
Birbes, H.1
El Bawab, S.2
Hannun, Y.A.3
Obeid, L.M.4
-
122
-
-
0037178790
-
Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins
-
Siskind, L. J.; Kolesnick, R. N.; Colombini, M. Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. J. Biol. Chem. 2002, 277, 26796-26803.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 26796-26803
-
-
Siskind, L.J.1
Kolesnick, R.N.2
Colombini, M.3
-
123
-
-
0034691760
-
Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells
-
Sawada, M.; Nakashima, S.; Banno, Y.; Yamakawa, H.; Takenaka, K.; Shinoda, J.; Nishimura, Y.; Sakai, N.; Nozawa, Y. Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells. Oncogene 2000, 19, 3508-3520.
-
(2000)
Oncogene
, vol.19
, pp. 3508-3520
-
-
Sawada, M.1
Nakashima, S.2
Banno, Y.3
Yamakawa, H.4
Takenaka, K.5
Shinoda, J.6
Nishimura, Y.7
Sakai, N.8
Nozawa, Y.9
-
124
-
-
15944425766
-
A mitochondrial pool of sphingomyelin is involved in TNFα-induced Bax translocation to mitochondria
-
Birbes, H.; Luberto, C.; Hsu, Y. T.; El Bawab, S.; Hannun, Y. A.; Obeid, L. M. A mitochondrial pool of sphingomyelin is involved in TNFα-induced Bax translocation to mitochondria. Biochem. J. 2005, 386, 445-451.
-
(2005)
Biochem. J
, vol.386
, pp. 445-451
-
-
Birbes, H.1
Luberto, C.2
Hsu, Y.T.3
El Bawab, S.4
Hannun, Y.A.5
Obeid, L.M.6
-
125
-
-
0037030465
-
Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells
-
Von Haefen, C.; Wieder, T.; Gillissen, B.; Starck, L.; Graupner, V.; Dorken, B.; Daniel, P. T. Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells. Oncogene 2002, 21, 4009-4019.
-
(2002)
Oncogene
, vol.21
, pp. 4009-4019
-
-
Von Haefen, C.1
Wieder, T.2
Gillissen, B.3
Starck, L.4
Graupner, V.5
Dorken, B.6
Daniel, P.T.7
-
126
-
-
0035860393
-
Bax-dependent apoptosis induced by ceramide in HL-60 cells
-
Kim, H. J.; Mun, J. Y.; Chun, Y. J.; Choi, K. H.; Kim, M. Y. Bax-dependent apoptosis induced by ceramide in HL-60 cells. FEBS Lett. 2001, 505, 264-268.
-
(2001)
FEBS Lett
, vol.505
, pp. 264-268
-
-
Kim, H.J.1
Mun, J.Y.2
Chun, Y.J.3
Choi, K.H.4
Kim, M.Y.5
-
127
-
-
84857873334
-
Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis
-
Chipuk, J. E.; McStay, G. P.; Bharti, A.; Kuwana, T.; Clarke, C. J.; Siskind, L. J.; Obeid, L. M.; Green, D. R. Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis. Cell 2012, 148, 988-1000.
-
(2012)
Cell
, vol.148
, pp. 988-1000
-
-
Chipuk, J.E.1
McStay, G.P.2
Bharti, A.3
Kuwana, T.4
Clarke, C.J.5
Siskind, L.J.6
Obeid, L.M.7
Green, D.R.8
-
128
-
-
84890065452
-
The impact of neighborhood composition on work-family conflict and distress
-
Young, M.; Wheaton, B. The impact of neighborhood composition on work-family conflict and distress. J. Health Soc. Behav. 2013, 54, 481-497.
-
(2013)
J. Health Soc. Behav
, vol.54
, pp. 481-497
-
-
Young, M.1
Wheaton, B.2
-
129
-
-
33745812349
-
Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation
-
Xin, M.; Deng, X. Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation. J. Biol. Chem. 2006, 281, 18859-18867.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 18859-18867
-
-
Xin, M.1
Deng, X.2
-
130
-
-
50049121874
-
Regulation and functions of sphingosine kinases in the brain
-
Bryan, L.; Kordula, T.; Spiegel, S.; Milstien, S. Regulation and functions of sphingosine kinases in the brain. Biochim. Biophys. Acta 2008, 1781, 459-466.
-
(2008)
Biochim. Biophys. Acta
, vol.1781
, pp. 459-466
-
-
Bryan, L.1
Kordula, T.2
Spiegel, S.3
Milstien, S.4
-
131
-
-
52449092057
-
Targeting SphK1 as a new strategy against cancer
-
Shida, D.; Takabe, K.; Kapitonov, D.; Milstien, S.; Spiegel, S. Targeting SphK1 as a new strategy against cancer. Curr. Drug Targets 2008, 9, 662-673.
-
(2008)
Curr. Drug Targets
, vol.9
, pp. 662-673
-
-
Shida, D.1
Takabe, K.2
Kapitonov, D.3
Milstien, S.4
Spiegel, S.5
-
132
-
-
77953966511
-
Sphingosine 1-phosphate and cancer
-
Pyne, N. J.; Pyne, S. Sphingosine 1-phosphate and cancer. Nat. Rev. Cancer 2010, 10, 489-503.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 489-503
-
-
Pyne, N.J.1
Pyne, S.2
-
133
-
-
29244457577
-
Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models
-
Pchejetski, D.; Golzio, M.; Bonhoure, E.; Calvet, C.; Doumerc, N.; Garcia, V.; Mazerolles, C.; Rischmann, P.; Teissie, J.; Malavaud, B.; et al. Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models. Cancer Res. 2005, 65, 11667-11675.
-
(2005)
Cancer Res
, vol.65
, pp. 11667-11675
-
-
Pchejetski, D.1
Golzio, M.2
Bonhoure, E.3
Calvet, C.4
Doumerc, N.5
Garcia, V.6
Mazerolles, C.7
Rischmann, P.8
Teissie, J.9
Malavaud, B.10
-
134
-
-
12444323123
-
Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: Role of Bcl-2 expression
-
Bektas, M.; Jolly, P. S.; Muller, C.; Eberle, J.; Spiegel, S.; Geilen, C. C. Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: Role of Bcl-2 expression. Oncogene 2005, 24, 178-187.
-
(2005)
Oncogene
, vol.24
, pp. 178-187
-
-
Bektas, M.1
Jolly, P.S.2
Muller, C.3
Eberle, J.4
Spiegel, S.5
Geilen, C.C.6
-
135
-
-
70349333252
-
Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway
-
Sukocheva, O.; Wang, L.; Verrier, E.; Vadas, M. A.; Xia, P. Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway. Endocrinology 2009, 150, 4484-4492.
-
(2009)
Endocrinology
, vol.150
, pp. 4484-4492
-
-
Sukocheva, O.1
Wang, L.2
Verrier, E.3
Vadas, M.A.4
Xia, P.5
-
136
-
-
20444506408
-
Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism
-
Taha, T. A.; Kitatani, K.; Bielawski, J.; Cho, W.; Hannun, Y. A.; Obeid, L. M. Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism. J. Biol. Chem. 2005, 280, 17196-17202.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 17196-17202
-
-
Taha, T.A.1
Kitatani, K.2
Bielawski, J.3
Cho, W.4
Hannun, Y.A.5
Obeid, L.M.6
-
137
-
-
27744479194
-
Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis
-
Okada, T.; Ding, G.; Sonoda, H.; Kajimoto, T.; Haga, Y.; Khosrowbeygi, A.; Gao, S.; Miwa, N.; Jahangeer, S.; Nakamura, S. Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis. J. Biol. Chem. 2005, 280, 36318-36325.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 36318-36325
-
-
Okada, T.1
Ding, G.2
Sonoda, H.3
Kajimoto, T.4
Haga, Y.5
Khosrowbeygi, A.6
Gao, S.7
Miwa, N.8
Jahangeer, S.9
Nakamura, S.10
-
138
-
-
0141924852
-
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis
-
Liu, H.; Toman, R. E.; Goparaju, S. K.; Maceyka, M.; Nava, V. E.; Sankala, H.; Payne, S. G.; Bektas, M.; Ishii, I.; Chun, J.; et al. Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. J. Biol. Chem. 2003, 278, 40330-40336.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 40330-40336
-
-
Liu, H.1
Toman, R.E.2
Goparaju, S.K.3
Maceyka, M.4
Nava, V.E.5
Sankala, H.6
Payne, S.G.7
Bektas, M.8
Ishii, I.9
Chun, J.10
-
139
-
-
0142091073
-
Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis
-
Igarashi, N.; Okada, T.; Hayashi, S.; Fujita, T.; Jahangeer, S.; Nakamura, S. Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. J. Biol. Chem. 2003, 278, 46832-46839.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 46832-46839
-
-
Igarashi, N.1
Okada, T.2
Hayashi, S.3
Fujita, T.4
Jahangeer, S.5
Nakamura, S.6
-
140
-
-
23844498431
-
Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: Roles of sphingosine kinase isoforms in growth of glioblastoma cell lines
-
Van Brocklyn, J. R.; Jackson, C. A.; Pearl, D. K.; Kotur, M. S.; Snyder, P. J.; Prior, T. W. Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: Roles of sphingosine kinase isoforms in growth of glioblastoma cell lines. J. Neuropathol. Exp. Neurol. 2005, 64, 695-705.
-
(2005)
J. Neuropathol. Exp. Neurol
, vol.64
, pp. 695-705
-
-
Van Brocklyn, J.R.1
Jackson, C.A.2
Pearl, D.K.3
Kotur, M.S.4
Snyder, P.J.5
Prior, T.W.6
-
141
-
-
34548065970
-
(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1
-
Min, J.; Mesika, A.; Sivaguru, M.; van Veldhoven, P. P.; Alexander, H.; Futerman, A. H.; Alexander, S. (Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1. Mol. Cancer Res. 2007, 5, 801-812.
-
(2007)
Mol. Cancer Res
, vol.5
, pp. 801-812
-
-
Min, J.1
Mesika, A.2
Sivaguru, M.3
van Veldhoven, P.P.4
Alexander, H.5
Futerman, A.H.6
Alexander, S.7
-
142
-
-
84862808791
-
Inhibition of sphingosine kinase 1 suppresses proliferation of glioma cells under hypoxia by attenuating activity of extracellular signal-regulated kinase
-
Zhang, H.; Li, W.; Sun, S.; Yu, S.; Zhang, M.; Zou, F. Inhibition of sphingosine kinase 1 suppresses proliferation of glioma cells under hypoxia by attenuating activity of extracellular signal-regulated kinase. Cell Prolif. 2012, 45, 167-175.
-
(2012)
Cell Prolif
, vol.45
, pp. 167-175
-
-
Zhang, H.1
Li, W.2
Sun, S.3
Yu, S.4
Zhang, M.5
Zou, F.6
-
143
-
-
0035089286
-
Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells
-
Edsall, L. C.; Cuvillier, O.; Twitty, S.; Spiegel, S.; Milstien, S. Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. J. Neurochem. 2001, 76, 1573-1584.
-
(2001)
J. Neurochem
, vol.76
, pp. 1573-1584
-
-
Edsall, L.C.1
Cuvillier, O.2
Twitty, S.3
Spiegel, S.4
Milstien, S.5
-
144
-
-
84879472607
-
Extracellular sphingosine-1-phosphate: A novel actor in human glioblastoma stem cell survival
-
Riccitelli, E.; Giussani, P.; di Vito, C.; Condomitti, G.; Tringali, C.; Caroli, M.; Galli, R.; Viani, P.; Riboni, L. Extracellular sphingosine-1-phosphate: A novel actor in human glioblastoma stem cell survival. PLoS One 2013, 8, e68229.
-
(2013)
PLoS One
, vol.8
-
-
Riccitelli, E.1
Giussani, P.2
di Vito, C.3
Condomitti, G.4
Tringali, C.5
Caroli, M.6
Galli, R.7
Viani, P.8
Riboni, L.9
-
145
-
-
27744547965
-
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism
-
Maceyka, M.; Sankala, H.; Hait, N. C.; le Stunff, H.; Liu, H.; Toman, R.; Collier, C.; Zhang, M.; Satin, L. S.; Merrill, A. H., Jr.; et al. SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. J. Biol. Chem. 2005, 280, 37118-37129.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 37118-37129
-
-
Maceyka, M.1
Sankala, H.2
Hait, N.C.3
le Stunff, H.4
Liu, H.5
Toman, R.6
Collier, C.7
Zhang, M.8
Satin, L.S.9
Merrill Jr., A.H.10
-
146
-
-
0037201970
-
Sphingosine-1-phosphate: Dual messenger functions
-
Payne, S. G.; Milstien, S.; Spiegel, S. Sphingosine-1-phosphate: Dual messenger functions. FEBS Lett. 2002, 531, 54-57.
-
(2002)
FEBS Lett
, vol.531
, pp. 54-57
-
-
Payne, S.G.1
Milstien, S.2
Spiegel, S.3
-
147
-
-
33645978074
-
Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors
-
Bassi, R.; Anelli, V.; Giussani, P.; Tettamanti, G.; Viani, P.; Riboni, L. Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors. Glia 2006, 53, 621-630.
-
(2006)
Glia
, vol.53
, pp. 621-630
-
-
Bassi, R.1
Anelli, V.2
Giussani, P.3
Tettamanti, G.4
Viani, P.5
Riboni, L.6
-
148
-
-
4544373119
-
Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis
-
Le Stunff, H.; Mikami, A.; Giussani, P.; Hobson, J. P.; Jolly, P. S.; Milstien, S.; Spiegel, S. Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis. J. Biol. Chem. 2004, 279, 34290-34297.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 34290-34297
-
-
Le Stunff, H.1
Mikami, A.2
Giussani, P.3
Hobson, J.P.4
Jolly, P.S.5
Milstien, S.6
Spiegel, S.7
-
149
-
-
0035853775
-
Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells
-
Igarashi, J.; Bernier, S. G.; Michel, T. Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. J. Biol. Chem. 2001, 276, 12420-12426.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 12420-12426
-
-
Igarashi, J.1
Bernier, S.G.2
Michel, T.3
-
150
-
-
0035966092
-
Sphingosine 1-phosphate activates nuclear factor-kappa B through Edg receptors. Activation through Edg-3 and Edg-5, but not Edg-1, in human embryonic kidney 293 cells
-
Siehler, S.; Wang, Y.; Fan, X.; Windh, R. T.; Manning, D. R. Sphingosine 1-phosphate activates nuclear factor-kappa B through Edg receptors. Activation through Edg-3 and Edg-5, but not Edg-1, in human embryonic kidney 293 cells. J. Biol. Chem. 2001, 276, 48733-48739.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 48733-48739
-
-
Siehler, S.1
Wang, Y.2
Fan, X.3
Windh, R.T.4
Manning, D.R.5
-
151
-
-
0032031519
-
Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1
-
Zondag, G. C.; Postma, F. R.; Etten, I. V.; Verlaan, I.; Moolenaar, W. H. Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1. Biochem. J. 1998, 330, 605-609.
-
(1998)
Biochem. J
, vol.330
, pp. 605-609
-
-
Zondag, G.C.1
Postma, F.R.2
Etten, I.V.3
Verlaan, I.4
Moolenaar, W.H.5
-
152
-
-
0242710592
-
2+ mobilization independently of G-protein-coupled receptors
-
2+ mobilization independently of G-protein-coupled receptors. FEBS Lett. 2003, 554, 443-449.
-
(2003)
FEBS Lett
, vol.554
, pp. 443-449
-
-
Meyer zu Heringdorf, D.1
Liliom, K.2
Schaefer, M.3
Danneberg, K.4
Jaggar, J.H.5
Tigyi, G.6
Jakobs, K.H.7
-
153
-
-
69949113620
-
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate
-
Hait, N. C.; Allegood, J.; Maceyka, M.; Strub, G. M.; Harikumar, K. B.; Singh, S. K.; Luo, C.; Marmorstein, R.; Kordula, T.; Milstien, S.; et al. Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 2009, 325, 1254-1257.
-
(2009)
Science
, vol.325
, pp. 1254-1257
-
-
Hait, N.C.1
Allegood, J.2
Maceyka, M.3
Strub, G.M.4
Harikumar, K.B.5
Singh, S.K.6
Luo, C.7
Marmorstein, R.8
Kordula, T.9
Milstien, S.10
-
154
-
-
0141507968
-
Discovery and evaluation of inhibitors of human sphingosine kinase
-
French, K. J.; Schrecengost, R. S.; Lee, B. D.; Zhuang, Y.; Smith, S. N.; Eberly, J. L.; Yun, J. K.; Smith, C. D. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003, 63, 5962-5969.
-
(2003)
Cancer Res
, vol.63
, pp. 5962-5969
-
-
French, K.J.1
Schrecengost, R.S.2
Lee, B.D.3
Zhuang, Y.4
Smith, S.N.5
Eberly, J.L.6
Yun, J.K.7
Smith, C.D.8
-
155
-
-
0030004270
-
Sphingosine and its methylated derivative N, N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines
-
Sweeney, E. A.; Sakakura, C.; Shirahama, T.; Masamune, A.; Ohta, H.; Hakomori, S.; Igarashi, Y. Sphingosine and its methylated derivative N, N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines. Int. J. Cancer. J. Int. Cancer 1996, 66, 358-366.
-
(1996)
Int. J. Cancer. J. Int. Cancer
, vol.66
, pp. 358-366
-
-
Sweeney, E.A.1
Sakakura, C.2
Shirahama, T.3
Masamune, A.4
Ohta, H.5
Hakomori, S.6
Igarashi, Y.7
-
156
-
-
0031035476
-
In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells
-
Shirahama, T.; Sweeney, E. A.; Sakakura, C.; Singhal, A. K.; Nishiyama, K.; Akiyama, S.; Hakomori, S.; Igarashi, Y. In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells. Clin. Cancer Res. 1997, 3, 257-264.
-
(1997)
Clin. Cancer Res
, vol.3
, pp. 257-264
-
-
Shirahama, T.1
Sweeney, E.A.2
Sakakura, C.3
Singhal, A.K.4
Nishiyama, K.5
Akiyama, S.6
Hakomori, S.7
Igarashi, Y.8
-
157
-
-
0035525748
-
Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria
-
Cuvillier, O.; Levade, T. Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. Blood 2001, 98, 2828-2836.
-
(2001)
Blood
, vol.98
, pp. 2828-2836
-
-
Cuvillier, O.1
Levade, T.2
-
158
-
-
84872911000
-
Novel agents targeting bioactive sphingolipids for the treatment of cancer
-
Adan-Gokbulut, A.; Kartal-Yandim, M.; Iskender, G.; Baran, Y. Novel agents targeting bioactive sphingolipids for the treatment of cancer. Curr. Med. Chem. 2013, 20, 108-122.
-
(2013)
Curr. Med. Chem
, vol.20
, pp. 108-122
-
-
Adan-Gokbulut, A.1
Kartal-Yandim, M.2
Iskender, G.3
Baran, Y.4
-
159
-
-
79954625512
-
A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors
-
Dickson, M. A.; Carvajal, R. D.; Merrill, A. H., Jr.; Gonen, M.; Cane, L. M.; Schwartz, G. K. A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors. Clin. Cancer Res. 2011, 17, 2484-2492.
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 2484-2492
-
-
Dickson, M.A.1
Carvajal, R.D.2
Merrill Jr., A.H.3
Gonen, M.4
Cane, L.M.5
Schwartz, G.K.6
-
160
-
-
70149120314
-
Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts
-
Kapitonov, D.; Allegood, J. C.; Mitchell, C.; Hait, N. C.; Almenara, J. A.; Adams, J. K.; Zipkin, R. E.; Dent, P.; Kordula, T.; Milstien, S.; et al. Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. Cancer Res. 2009, 69, 6915-6923.
-
(2009)
Cancer Res
, vol.69
, pp. 6915-6923
-
-
Kapitonov, D.1
Allegood, J.C.2
Mitchell, C.3
Hait, N.C.4
Almenara, J.A.5
Adams, J.K.6
Zipkin, R.E.7
Dent, P.8
Kordula, T.9
Milstien, S.10
-
161
-
-
77951085269
-
A novel sphingosine kinase inhibitor induces autophagy in tumor cells
-
Beljanski, V.; Knaak, C.; Smith, C. D. A novel sphingosine kinase inhibitor induces autophagy in tumor cells. J. Pharmacol. Exp. Ther. 2010, 333, 454-464.
-
(2010)
J. Pharmacol. Exp. Ther
, vol.333
, pp. 454-464
-
-
Beljanski, V.1
Knaak, C.2
Smith, C.D.3
-
162
-
-
0037739755
-
A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells
-
Matsuoka, Y.; Nagahara, Y.; Ikekita, M.; Shinomiya, T. A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells. Br. J. Pharmacol. 2003, 138, 1303-1312.
-
(2003)
Br. J. Pharmacol
, vol.138
, pp. 1303-1312
-
-
Matsuoka, Y.1
Nagahara, Y.2
Ikekita, M.3
Shinomiya, T.4
-
163
-
-
0038286415
-
Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment
-
Azuma, H.; Takahara, S.; Horie, S.; Muto, S.; Otsuki, Y.; Katsuoka, Y. Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment. J. Urol. 2003, 169, 2372-2377.
-
(2003)
J. Urol
, vol.169
, pp. 2372-2377
-
-
Azuma, H.1
Takahara, S.2
Horie, S.3
Muto, S.4
Otsuki, Y.5
Katsuoka, Y.6
-
164
-
-
0034813958
-
FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cells
-
Sonoda, Y.; Yamamoto, D.; Sakurai, S.; Hasegawa, M.; Aizu-Yokota, E.; Momoi, T.; Kasahara, T. FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cells. Biochem. Biophys. Res. Commun. 2001, 281, 282-288.
-
(2001)
Biochem. Biophys. Res. Commun
, vol.281
, pp. 282-288
-
-
Sonoda, Y.1
Yamamoto, D.2
Sakurai, S.3
Hasegawa, M.4
Aizu-Yokota, E.5
Momoi, T.6
Kasahara, T.7
-
165
-
-
0033564177
-
Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation
-
Wang, J. D.; Takahara, S.; Nonomura, N.; Ichimaru, N.; Toki, K.; Azuma, H.; Matsumiya, K.; Okuyama, A.; Suzuki, S. Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation. Prostate 1999, 40, 50-55.
-
(1999)
Prostate
, vol.40
, pp. 50-55
-
-
Wang, J.D.1
Takahara, S.2
Nonomura, N.3
Ichimaru, N.4
Toki, K.5
Azuma, H.6
Matsumiya, K.7
Okuyama, A.8
Suzuki, S.9
-
166
-
-
23844515685
-
FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance
-
Yasui, H.; Hideshima, T.; Raje, N.; Roccaro, A. M.; Shiraishi, N.; Kumar, S.; Hamasaki, M.; Ishitsuka, K.; Tai, Y. T.; Podar, K.; et al. FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance. Cancer Res. 2005, 65, 7478-7484.
-
(2005)
Cancer Res
, vol.65
, pp. 7478-7484
-
-
Yasui, H.1
Hideshima, T.2
Raje, N.3
Roccaro, A.M.4
Shiraishi, N.5
Kumar, S.6
Hamasaki, M.7
Ishitsuka, K.8
Tai, Y.T.9
Podar, K.10
-
167
-
-
0036494268
-
Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models
-
Azuma, H.; Takahara, S.; Ichimaru, N.; Wang, J. D.; Itoh, Y.; Otsuki, Y.; Morimoto, J.; Fukui, R.; Hoshiga, M.; Ishihara, T.; et al. Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models. Cancer Res. 2002, 62, 1410-1419.
-
(2002)
Cancer Res
, vol.62
, pp. 1410-1419
-
-
Azuma, H.1
Takahara, S.2
Ichimaru, N.3
Wang, J.D.4
Itoh, Y.5
Otsuki, Y.6
Morimoto, J.7
Fukui, R.8
Hoshiga, M.9
Ishihara, T.10
-
168
-
-
84455172960
-
Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage
-
Lepine, S.; Allegood, J. C.; Edmonds, Y.; Milstien, S.; Spiegel, S. Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage. J. Biol. Chem. 2011, 286, 44380-44390.
-
(2011)
J. Biol. Chem
, vol.286
, pp. 44380-44390
-
-
Lepine, S.1
Allegood, J.C.2
Edmonds, Y.3
Milstien, S.4
Spiegel, S.5
-
169
-
-
84859480341
-
Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis
-
Young, M. M.; Takahashi, Y.; Khan, O.; Park, S.; Hori, T.; Yun, J.; Sharma, A. K.; Amin, S.; Hu, C. D.; Zhang, J.; et al. Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis. J. Biol. Chem. 2012, 287, 12455-12468.
-
(2012)
J. Biol. Chem
, vol.287
, pp. 12455-12468
-
-
Young, M.M.1
Takahashi, Y.2
Khan, O.3
Park, S.4
Hori, T.5
Yun, J.6
Sharma, A.K.7
Amin, S.8
Hu, C.D.9
Zhang, J.10
-
170
-
-
2442485884
-
Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1
-
Scarlatti, F.; Bauvy, C.; Ventruti, A.; Sala, G.; Cluzeaud, F.; Vandewalle, A.; Ghidoni, R.; Codogno, P. Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J. Biol. Chem. 2004, 279, 18384-18391.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 18384-18391
-
-
Scarlatti, F.1
Bauvy, C.2
Ventruti, A.3
Sala, G.4
Cluzeaud, F.5
Vandewalle, A.6
Ghidoni, R.7
Codogno, P.8
-
171
-
-
0037458741
-
Altered sphingolipid metabolism in N-(4-hydroxyphenyl)-retinamide-resistant A2780 human ovarian carcinoma cells
-
Prinetti, A.; Basso, L.; Appierto, V.; Villani, M. G.; Valsecchi, M.; Loberto, N.; Prioni, S.; Chigorno, V.; Cavadini, E.; Formelli, F.; et al. Altered sphingolipid metabolism in N-(4-hydroxyphenyl)-retinamide-resistant A2780 human ovarian carcinoma cells. J. Biol. Chem. 2003, 278, 5574-5583.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 5574-5583
-
-
Prinetti, A.1
Basso, L.2
Appierto, V.3
Villani, M.G.4
Valsecchi, M.5
Loberto, N.6
Prioni, S.7
Chigorno, V.8
Cavadini, E.9
Formelli, F.10
-
172
-
-
33645774990
-
Lack of ceramide generation and altered sphingolipid composition are associated with drug resistance in human ovarian carcinoma cells
-
Prinetti, A.; Millimaggi, D.; D'Ascenzo, S.; Clarkson, M.; Bettiga, A.; Chigorno, V.; Sonnino, S.; Pavan, A.; Dolo, V. Lack of ceramide generation and altered sphingolipid composition are associated with drug resistance in human ovarian carcinoma cells. Biochem. J. 2006, 395, 311-318.
-
(2006)
Biochem. J
, vol.395
, pp. 311-318
-
-
Prinetti, A.1
Millimaggi, D.2
D'Ascenzo, S.3
Clarkson, M.4
Bettiga, A.5
Chigorno, V.6
Sonnino, S.7
Pavan, A.8
Dolo, V.9
-
173
-
-
0036632690
-
Altered sphingolipid metabolism in multidrug-resistant ovarian cancer cells is due to uncoupling of glycolipid biosynthesis in the Golgi apparatus
-
Veldman, R. J.; Klappe, K.; Hinrichs, J.; Hummel, I.; van der Schaaf, G.; Sietsma, H.; Kok, J. W. Altered sphingolipid metabolism in multidrug-resistant ovarian cancer cells is due to uncoupling of glycolipid biosynthesis in the Golgi apparatus. FASEB J. 2002, 16, 1111-1113.
-
(2002)
FASEB J
, vol.16
, pp. 1111-1113
-
-
Veldman, R.J.1
Klappe, K.2
Hinrichs, J.3
Hummel, I.4
van der Schaaf, G.5
Sietsma, H.6
Kok, J.W.7
-
174
-
-
0042737522
-
Differential expression of sphingolipids in P-glycoprotein or multidrug resistance-related protein 1 expressing human neuroblastoma cell lines
-
Dijkhuis, A. J.; Douwes, J.; Kamps, W.; Sietsma, H.; Kok, J. W. Differential expression of sphingolipids in P-glycoprotein or multidrug resistance-related protein 1 expressing human neuroblastoma cell lines. FEBS Lett. 2003, 548, 28-32.
-
(2003)
FEBS Lett
, vol.548
, pp. 28-32
-
-
Dijkhuis, A.J.1
Douwes, J.2
Kamps, W.3
Sietsma, H.4
Kok, J.W.5
-
175
-
-
0036073348
-
Influence of ceramide metabolism on P-glycoprotein function in immature acute myeloid leukemia KG1a cells
-
Plo, I.; Lehne, G.; Beckstrom, K. J.; Maestre, N.; Bettaieb, A.; Laurent, G.; Lautier, D. Influence of ceramide metabolism on P-glycoprotein function in immature acute myeloid leukemia KG1a cells. Mol. Pharmacol. 2002, 62, 304-312.
-
(2002)
Mol. Pharmacol
, vol.62
, pp. 304-312
-
-
Plo, I.1
Lehne, G.2
Beckstrom, K.J.3
Maestre, N.4
Bettaieb, A.5
Laurent, G.6
Lautier, D.7
-
176
-
-
0034528032
-
Cell adhesion/recognition and signal transduction through glycosphingolipid microdomain
-
Hakomori, S. I. Cell adhesion/recognition and signal transduction through glycosphingolipid microdomain. Glycoconj. J. 2000, 17, 143-151.
-
(2000)
Glycoconj. J
, vol.17
, pp. 143-151
-
-
Hakomori, S.I.1
-
177
-
-
61349094775
-
NEU3 sialidase strictly modulates GM3 levels in skeletal myoblasts C2C12 thus favoring their differentiation and protecting them from apoptosis
-
Anastasia, L.; Papini, N.; Colazzo, F.; Palazzolo, G.; Tringali, C.; Dileo, L.; Piccoli, M.; Conforti, E.; Sitzia, C.; Monti, E.; et al. NEU3 sialidase strictly modulates GM3 levels in skeletal myoblasts C2C12 thus favoring their differentiation and protecting them from apoptosis. J. Biol. Chem. 2008, 283, 36265-36271.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 36265-36271
-
-
Anastasia, L.1
Papini, N.2
Colazzo, F.3
Palazzolo, G.4
Tringali, C.5
Dileo, L.6
Piccoli, M.7
Conforti, E.8
Sitzia, C.9
Monti, E.10
-
178
-
-
50449105552
-
isialoganglioside GD3 synthase expression recruits membrane transglutaminase 2 during erythroid differentiation of the human chronic myelogenous leukemia K562 cells
-
Kang, S. K.; Kim, Y. S.; Kong, Y. J.; Song, K. H.; Chang, Y. C.; Park, Y. G.; Ko, J. H.; Lee, Y. C.; Kim, C. H. isialoganglioside GD3 synthase expression recruits membrane transglutaminase 2 during erythroid differentiation of the human chronic myelogenous leukemia K562 cells. Proteomics 2008, 8, 3317-3328.
-
(2008)
Proteomics
, vol.8
, pp. 3317-3328
-
-
Kang, S.K.1
Kim, Y.S.2
Kong, Y.J.3
Song, K.H.4
Chang, Y.C.5
Park, Y.G.6
Ko, J.H.7
Lee, Y.C.8
Kim, C.H.9
-
179
-
-
3843114549
-
Alterations in neuroblastoma ganglioside synthesis by induction of GD1b synthase by retinoic acid
-
Hettmer, S.; McCarter, R.; Ladisch, S.; Kaucic, K. Alterations in neuroblastoma ganglioside synthesis by induction of GD1b synthase by retinoic acid. Br. J. Cancer 2004, 91, 389-397.
-
(2004)
Br. J. Cancer
, vol.91
, pp. 389-397
-
-
Hettmer, S.1
McCarter, R.2
Ladisch, S.3
Kaucic, K.4
-
180
-
-
0036913798
-
Glycotherapy for cancer: Remodeling of ganglioside pattern as an effective approach for cancer therapy
-
Nojiri, H.; Yamana, H.; Shirouzu, G.; Suzuki, T.; Isono, H. Glycotherapy for cancer: Remodeling of ganglioside pattern as an effective approach for cancer therapy. Cancer Detect. Prev. 2002, 26, 114-120.
-
(2002)
Cancer Detect. Prev
, vol.26
, pp. 114-120
-
-
Nojiri, H.1
Yamana, H.2
Shirouzu, G.3
Suzuki, T.4
Isono, H.5
-
181
-
-
57649217883
-
Silencing of membrane-associated sialidase Neu3 diminishes apoptosis resistance and triggers megakaryocytic differentiation of chronic myeloid leukemic cells K562 through the increase of ganglioside GM3
-
Tringali, C.; Lupo, B.; Cirillo, F.; Papini, N.; Anastasia, L.; Lamorte, G.; Colombi, P.; Bresciani, R.; Monti, E.; Tettamanti, G.; et al. Silencing of membrane-associated sialidase Neu3 diminishes apoptosis resistance and triggers megakaryocytic differentiation of chronic myeloid leukemic cells K562 through the increase of ganglioside GM3. Cell Death Differ. 2009, 16, 164-174.
-
(2009)
Cell Death Differ
, vol.16
, pp. 164-174
-
-
Tringali, C.1
Lupo, B.2
Cirillo, F.3
Papini, N.4
Anastasia, L.5
Lamorte, G.6
Colombi, P.7
Bresciani, R.8
Monti, E.9
Tettamanti, G.10
-
182
-
-
66149101390
-
Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines
-
Guan, F.; Handa, K.; Hakomori, S. I. Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines. Proc. Natl. Acad. Sci. USA 2009, 106, 7461-7466.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 7461-7466
-
-
Guan, F.1
Handa, K.2
Hakomori, S.I.3
-
183
-
-
78649369742
-
The epithelial-mesenchymal transition (EMT) phenomenon
-
Savagner, P. The epithelial-mesenchymal transition (EMT) phenomenon. Ann. Oncol. 2010, 21, vii89-vii92.
-
(2010)
Ann. Oncol
, vol.21
-
-
Savagner, P.1
-
184
-
-
77951073166
-
Death receptor 5-recruited raft components contributes to the sensitivity of Jurkat leukemia cell lines to TRAIL-induced cell death
-
Min, Y.; Shi, J.; Zhang, Y.; Liu, S.; Liu, Y.; Zheng, D. Death receptor 5-recruited raft components contributes to the sensitivity of Jurkat leukemia cell lines to TRAIL-induced cell death. IUBMB Life 2009, 61, 261-267.
-
(2009)
IUBMB Life
, vol.61
, pp. 261-267
-
-
Min, Y.1
Shi, J.2
Zhang, Y.3
Liu, S.4
Liu, Y.5
Zheng, D.6
-
185
-
-
34447094000
-
TRAIL signalling: Decisions between life and death
-
Falschlehner, C.; Emmerich, C. H.; Gerlach, B.; Walczak, H. TRAIL signalling: Decisions between life and death. Int. J. Biochem. Cell Biol. 2007, 39, 1462-1475.
-
(2007)
Int. J. Biochem. Cell Biol
, vol.39
, pp. 1462-1475
-
-
Falschlehner, C.1
Emmerich, C.H.2
Gerlach, B.3
Walczak, H.4
-
186
-
-
79955757680
-
Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells
-
Lim, S. C.; Duong, H. Q.; Choi, J. E.; Lee, T. B.; Kang, J. H.; Oh, S. H.; Han, S. I. Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells. Carcinogenesis 2011, 32, 723-731.
-
(2011)
Carcinogenesis
, vol.32
, pp. 723-731
-
-
Lim, S.C.1
Duong, H.Q.2
Choi, J.E.3
Lee, T.B.4
Kang, J.H.5
Oh, S.H.6
Han, S.I.7
-
187
-
-
84873657492
-
Absence of death receptor translocation into lipid rafts in acquired TRAIL-resistant NSCLC cells
-
Ouyang, W.; Yang, C.; Zhang, S.; Liu, Y.; Yang, B.; Zhang, J.; Zhou, F.; Zhou, Y.; Xie, C. Absence of death receptor translocation into lipid rafts in acquired TRAIL-resistant NSCLC cells. Int. J. Oncol. 2013, 42, 699-711.
-
(2013)
Int. J. Oncol
, vol.42
, pp. 699-711
-
-
Ouyang, W.1
Yang, C.2
Zhang, S.3
Liu, Y.4
Yang, B.5
Zhang, J.6
Zhou, F.7
Zhou, Y.8
Xie, C.9
-
188
-
-
79959596868
-
Death receptor 4 is preferentially recruited to lipid rafts in chronic lymphocytic leukemia cells contributing to tumor necrosis related apoptosis inducing ligand-induced synergistic apoptotic responses
-
Xiao, W.; Ishdorj, G.; Sun, J.; Johnston, J. B.; Gibson, S. B. Death receptor 4 is preferentially recruited to lipid rafts in chronic lymphocytic leukemia cells contributing to tumor necrosis related apoptosis inducing ligand-induced synergistic apoptotic responses. Leuk. Lymphoma 2011, 52, 1290-1301.
-
(2011)
Leuk. Lymphoma
, vol.52
, pp. 1290-1301
-
-
Xiao, W.1
Ishdorj, G.2
Sun, J.3
Johnston, J.B.4
Gibson, S.B.5
-
189
-
-
84887467272
-
Constitutive localization of DR4 in lipid rafts is mandatory for TRAIL-induced apoptosis in B-cell hematologic malignancies
-
Marconi, M.; Ascione, B.; Ciarlo, L.; Vona, R.; Garofalo, T.; Sorice, M.; Gianni, A. M.; Locatelli, S. L.; Carlo-Stella, C.; Malorni, W.; et al. Constitutive localization of DR4 in lipid rafts is mandatory for TRAIL-induced apoptosis in B-cell hematologic malignancies. Cell Death Dis. 2013, 4, e863.
-
(2013)
Cell Death Dis
, vol.4
-
-
Marconi, M.1
Ascione, B.2
Ciarlo, L.3
Vona, R.4
Garofalo, T.5
Sorice, M.6
Gianni, A.M.7
Locatelli, S.L.8
Carlo-Stella, C.9
Malorni, W.10
-
190
-
-
84871110223
-
The plasma membrane sialidase NEU3 regulates the malignancy of renal carcinoma cells by controlling β1 integrin internalization and recycling
-
Tringali, C.; Lupo, B.; Silvestri, I.; Papini, N.; Anastasia, L.; Tettamanti, G.; Venerando, B. The plasma membrane sialidase NEU3 regulates the malignancy of renal carcinoma cells by controlling β1 integrin internalization and recycling. J. Biol. Chem. 2012, 287, 42835-42845.
-
(2012)
J. Biol. Chem
, vol.287
, pp. 42835-42845
-
-
Tringali, C.1
Lupo, B.2
Silvestri, I.3
Papini, N.4
Anastasia, L.5
Tettamanti, G.6
Venerando, B.7
-
192
-
-
0028197247
-
Gangliosides associated with primary brain tumors and their expression in cell lines established from these tumors
-
Fredman, P. Gangliosides associated with primary brain tumors and their expression in cell lines established from these tumors. Prog. Brain Res. 1994, 101, 225-240.
-
(1994)
Prog. Brain Res
, vol.101
, pp. 225-240
-
-
Fredman, P.1
-
193
-
-
0022218863
-
Correlation between ganglioside distribution and histological grading of human astrocytomas
-
Berra, B.; Gaini, S. M.; Riboni, L. Correlation between ganglioside distribution and histological grading of human astrocytomas. Int. J. Cancer 1985, 36, 363-366.
-
(1985)
Int. J. Cancer
, vol.36
, pp. 363-366
-
-
Berra, B.1
Gaini, S.M.2
Riboni, L.3
-
194
-
-
0035983292
-
Ceramide levels are inversely associated with malignant progression of human glial tumors
-
Riboni, L.; Campanella, R.; Bassi, R.; Villani, R.; Gaini, S. M.; Martinelli-Boneschi, F.; Viani, P.; Tettamanti, G. Ceramide levels are inversely associated with malignant progression of human glial tumors. Glia 2002, 39, 105-113.
-
(2002)
Glia
, vol.39
, pp. 105-113
-
-
Riboni, L.1
Campanella, R.2
Bassi, R.3
Villani, R.4
Gaini, S.M.5
Martinelli-Boneschi, F.6
Viani, P.7
Tettamanti, G.8
-
196
-
-
0343883506
-
Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation
-
Garcia-Ruiz, C.; Colell, A.; Paris, R.; Fernandez-Checa, J. C. Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation. FASEB J. 2000, 14, 847-858.
-
(2000)
FASEB J
, vol.14
, pp. 847-858
-
-
Garcia-Ruiz, C.1
Colell, A.2
Paris, R.3
Fernandez-Checa, J.C.4
-
197
-
-
0034068601
-
Mitochondrial control of cell death
-
Kroemer, G.; Reed, J. C. Mitochondrial control of cell death. Nat. Med. 2000, 6, 513-519.
-
(2000)
Nat. Med
, vol.6
, pp. 513-519
-
-
Kroemer, G.1
Reed, J.C.2
-
198
-
-
0033810454
-
GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion
-
Rippo, M. R.; Malisan, F.; Ravagnan, L.; Tomassini, B.; Condo, I.; Costantini, P.; Susin, S. A.; Rufini, A.; Todaro, M.; Kroemer, G.; et al. GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion. FASEB J. 2000, 14, 2047-2054.
-
(2000)
FASEB J
, vol.14
, pp. 2047-2054
-
-
Rippo, M.R.1
Malisan, F.2
Ravagnan, L.3
Tomassini, B.4
Condo, I.5
Costantini, P.6
Susin, S.A.7
Rufini, A.8
Todaro, M.9
Kroemer, G.10
-
199
-
-
0032536876
-
Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells
-
De Maria, R.; Rippo, M. R.; Schuchman, E. H.; Testi, R. Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells. J. Exp. Med. 1998, 187, 897-902.
-
(1998)
J. Exp. Med
, vol.187
, pp. 897-902
-
-
De Maria, R.1
Rippo, M.R.2
Schuchman, E.H.3
Testi, R.4
-
200
-
-
0037189948
-
Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-α-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation. Possible role of ganglioside GD3
-
Colell, A.; Morales, A.; Fernandez-Checa, J. C.; Garcia-Ruiz, C. Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-α-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation. Possible role of ganglioside GD3. FEBS Lett. 2002, 526, 135-141.
-
(2002)
FEBS Lett
, vol.526
, pp. 135-141
-
-
Colell, A.1
Morales, A.2
Fernandez-Checa, J.C.3
Garcia-Ruiz, C.4
-
201
-
-
4444346464
-
Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide
-
Lovat, P. E.; di Sano, F.; Corazzari, M.; Fazi, B.; Donnorso, R. P.; Pearson, A. D.; Hall, A. G.; Redfern, C. P.; Piacentini, M. Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide. J. Natl. Cancer Inst. 2004, 96, 1288-1299.
-
(2004)
J. Natl. Cancer Inst
, vol.96
, pp. 1288-1299
-
-
Lovat, P.E.1
di Sano, F.2
Corazzari, M.3
Fazi, B.4
Donnorso, R.P.5
Pearson, A.D.6
Hall, A.G.7
Redfern, C.P.8
Piacentini, M.9
-
202
-
-
0038532523
-
Role of tumor-associated gangliosides in cancer progression
-
Birkle, S.; Zeng, G.; Gao, L.; Yu, R. K.; Aubry, J. Role of tumor-associated gangliosides in cancer progression. Biochimie 2003, 85, 455-463.
-
(2003)
Biochimie
, vol.85
, pp. 455-463
-
-
Birkle, S.1
Zeng, G.2
Gao, L.3
Yu, R.K.4
Aubry, J.5
-
203
-
-
0029871064
-
Vascular endothelial growth factor production is stimulated by gangliosides and TGF-β isoforms in human glioma cells in vitro
-
Koochekpour, S.; Merzak, A.; Pilkington, G. J. Vascular endothelial growth factor production is stimulated by gangliosides and TGF-β isoforms in human glioma cells in vitro. Cancer Lett. 1996, 102, 209-215.
-
(1996)
Cancer Lett
, vol.102
, pp. 209-215
-
-
Koochekpour, S.1
Merzak, A.2
Pilkington, G.J.3
-
204
-
-
0027079971
-
Angiogenesis can be stimulated or repressed in vivo by a change in GM3: GD3 ganglioside ratio
-
Ziche, M.; Morbidelli, L.; Alessandri, G.; Gullino, P. M. Angiogenesis can be stimulated or repressed in vivo by a change in GM3: GD3 ganglioside ratio. Lab. Investig. 1992, 67, 711-715.
-
(1992)
Lab. Investig
, vol.67
, pp. 711-715
-
-
Ziche, M.1
Morbidelli, L.2
Alessandri, G.3
Gullino, P.M.4
-
205
-
-
0034541197
-
Suppression of ganglioside GD3 expression in a rat F-11 tumor cell line reduces tumor growth, angiogenesis, and vascular endothelial growth factor production
-
Zeng, G.; Gao, L.; Birkle, S.; Yu, R. K. Suppression of ganglioside GD3 expression in a rat F-11 tumor cell line reduces tumor growth, angiogenesis, and vascular endothelial growth factor production. Cancer Res. 2000, 60, 6670-6676.
-
(2000)
Cancer Res
, vol.60
, pp. 6670-6676
-
-
Zeng, G.1
Gao, L.2
Birkle, S.3
Yu, R.K.4
-
206
-
-
0037122008
-
Acetylation suppresses the proapoptotic activity of GD3 ganglioside
-
Malisan, F.; Franchi, L.; Tomassini, B.; Ventura, N.; Condo, I.; Rippo, M. R.; Rufini, A.; Liberati, L.; Nachtigall, C.; Kniep, B.; et al. Acetylation suppresses the proapoptotic activity of GD3 ganglioside. J. Exp. Med. 2002, 196, 1535-1541.
-
(2002)
J. Exp. Med
, vol.196
, pp. 1535-1541
-
-
Malisan, F.1
Franchi, L.2
Tomassini, B.3
Ventura, N.4
Condo, I.5
Rippo, M.R.6
Rufini, A.7
Liberati, L.8
Nachtigall, C.9
Kniep, B.10
-
207
-
-
54849417790
-
O-acetylation of GD3 prevents its apoptotic effect and promotes survival of lymphoblasts in childhood acute lymphoblastic leukaemia
-
Mukherjee, K.; Chava, A. K.; Mandal, C.; Dey, S. N.; Kniep, B.; Chandra, S.; Mandal, C. O-acetylation of GD3 prevents its apoptotic effect and promotes survival of lymphoblasts in childhood acute lymphoblastic leukaemia. J. Cell. Biochem. 2008, 105, 724-734.
-
(2008)
J. Cell. Biochem
, vol.105
, pp. 724-734
-
-
Mukherjee, K.1
Chava, A.K.2
Mandal, C.3
Dey, S.N.4
Kniep, B.5
Chandra, S.6
Mandal, C.7
-
208
-
-
80052780117
-
Targeting the GD3 acetylation pathway selectively induces apoptosis in glioblastoma
-
Birks, S. M.; Danquah, J. O.; King, L.; Vlasak, R.; Gorecki, D. C.; Pilkington, G. J. Targeting the GD3 acetylation pathway selectively induces apoptosis in glioblastoma. Neuro-Oncol. 2011, 13, 950-960.
-
(2011)
Neuro-Oncol
, vol.13
, pp. 950-960
-
-
Birks, S.M.1
Danquah, J.O.2
King, L.3
Vlasak, R.4
Gorecki, D.C.5
Pilkington, G.J.6
-
209
-
-
73549095984
-
Down regulation of membrane-bound Neu3 constitutes a new potential marker for childhood acute lymphoblastic leukemia and induces apoptosis suppression of neoplastic cells
-
Mandal, C.; Tringali, C.; Mondal, S.; Anastasia, L.; Chandra, S.; Venerando, B.; Mandal, C. Down regulation of membrane-bound Neu3 constitutes a new potential marker for childhood acute lymphoblastic leukemia and induces apoptosis suppression of neoplastic cells. Int. J. Cancer J. Int. Cancer 2010, 126, 337-349.
-
(2010)
Int. J. Cancer J. Int. Cancer
, vol.126
, pp. 337-349
-
-
Mandal, C.1
Tringali, C.2
Mondal, S.3
Anastasia, L.4
Chandra, S.5
Venerando, B.6
Mandal, C.7
-
210
-
-
0037121944
-
O-acetylation of GD3: An enigmatic modification regulating apoptosis?
-
Chen, H. Y.; Varki, A. O-acetylation of GD3: An enigmatic modification regulating apoptosis? J. Exp. Med. 2002, 196, 1529-1533.
-
(2002)
J. Exp. Med
, vol.196
, pp. 1529-1533
-
-
Chen, H.Y.1
Varki, A.2
-
211
-
-
9444240330
-
Calnexin suppresses GD3 synthase-induced apoptosis
-
Tomassini, B.; Malisan, F.; Franchi, L.; Nicolo, C.; Calvo, G. B.; Saito, T.; Testi, R. Calnexin suppresses GD3 synthase-induced apoptosis. FASEB J. 2004, 18, 1553-1555.
-
(2004)
FASEB J
, vol.18
, pp. 1553-1555
-
-
Tomassini, B.1
Malisan, F.2
Franchi, L.3
Nicolo, C.4
Calvo, G.B.5
Saito, T.6
Testi, R.7
-
212
-
-
23444435304
-
The ganglioside GD3 as the Greek goddess Hecate: Several faces turned towards as many directions
-
Malisan, F.; Testi, R. The ganglioside GD3 as the Greek goddess Hecate: Several faces turned towards as many directions. IUBMB Life 2005, 57, 477-482.
-
(2005)
IUBMB Life
, vol.57
, pp. 477-482
-
-
Malisan, F.1
Testi, R.2
-
213
-
-
0036645424
-
Ganglioside G(M3) overexpression induces apoptosis and reduces malignant potential in murine bladder cancer
-
Watanabe, R.; Ohyama, C.; Aoki, H.; Takahashi, T.; Satoh, M.; Saito, S.; Hoshi, S.; Ishii, A.; Saito, M.; Arai, Y. Ganglioside G(M3) overexpression induces apoptosis and reduces malignant potential in murine bladder cancer. Cancer Res. 2002, 62, 3850-3854.
-
(2002)
Cancer Res
, vol.62
, pp. 3850-3854
-
-
Watanabe, R.1
Ohyama, C.2
Aoki, H.3
Takahashi, T.4
Satoh, M.5
Saito, S.6
Hoshi, S.7
Ishii, A.8
Saito, M.9
Arai, Y.10
-
214
-
-
34548146344
-
GM3 synthase gene is a novel biomarker for histological classification and drug sensitivity against epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
-
Noguchi, M.; Suzuki, T.; Kabayama, K.; Takahashi, H.; Chiba, H.; Shiratori, M.; Abe, S.; Watanabe, A.; Satoh, M.; Hasegawa, T.; et al. GM3 synthase gene is a novel biomarker for histological classification and drug sensitivity against epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Cancer Sci. 2007, 98, 1625-1632.
-
(2007)
Cancer Sci
, vol.98
, pp. 1625-1632
-
-
Noguchi, M.1
Suzuki, T.2
Kabayama, K.3
Takahashi, H.4
Chiba, H.5
Shiratori, M.6
Abe, S.7
Watanabe, A.8
Satoh, M.9
Hasegawa, T.10
-
215
-
-
0031813499
-
An alteration of ganglioside composition in cisplatin-resistant lung cancer cell line
-
Kiura, K.; Watarai, S.; Ueoka, H.; Tabata, M.; Gemba, K.; Aoe, K.; Yamane, H.; Yasuda, T.; Harada, M. An alteration of ganglioside composition in cisplatin-resistant lung cancer cell line. Anticancer Res. 1998, 18, 2957-2960.
-
(1998)
Anticancer Res
, vol.18
, pp. 2957-2960
-
-
Kiura, K.1
Watarai, S.2
Ueoka, H.3
Tabata, M.4
Gemba, K.5
Aoe, K.6
Yamane, H.7
Yasuda, T.8
Harada, M.9
-
216
-
-
0037366696
-
Sialylation and sulfation of lactosylceramide distinctly regulate anchorage-independent growth, apoptosis, and gene expression in 3LL Lewis lung carcinoma cells
-
Uemura, S.; Kabayama, K.; Noguchi, M.; Igarashi, Y.; Inokuchi, J. Sialylation and sulfation of lactosylceramide distinctly regulate anchorage-independent growth, apoptosis, and gene expression in 3LL Lewis lung carcinoma cells. Glycobiology 2003, 13, 207-216.
-
(2003)
Glycobiology
, vol.13
, pp. 207-216
-
-
Uemura, S.1
Kabayama, K.2
Noguchi, M.3
Igarashi, Y.4
Inokuchi, J.5
-
217
-
-
33745630666
-
Endogenously produced ganglioside GM3 endows etoposide and doxorubicin resistance by up-regulating Bcl-2 expression in 3LL Lewis lung carcinoma cells
-
Noguchi, M.; Kabayama, K.; Uemura, S.; Kang, B. W.; Saito, M.; Igarashi, Y.; Inokuchi, J. Endogenously produced ganglioside GM3 endows etoposide and doxorubicin resistance by up-regulating Bcl-2 expression in 3LL Lewis lung carcinoma cells. Glycobiology 2006, 16, 641-650.
-
(2006)
Glycobiology
, vol.16
, pp. 641-650
-
-
Noguchi, M.1
Kabayama, K.2
Uemura, S.3
Kang, B.W.4
Saito, M.5
Igarashi, Y.6
Inokuchi, J.7
-
218
-
-
72249088570
-
De-N-acetyl GM3 promotes melanoma cell migration and invasion through urokinase plasminogen activator receptor signaling-dependent MMP-2 activation
-
Liu, J. W.; Sun, P.; Yan, Q.; Paller, A. S.; Gerami, P.; Ho, N.; Vashi, N.; le Poole, I. C.; Wang, X. Q. De-N-acetyl GM3 promotes melanoma cell migration and invasion through urokinase plasminogen activator receptor signaling-dependent MMP-2 activation. Cancer Res. 2009, 69, 8662-8669.
-
(2009)
Cancer Res
, vol.69
, pp. 8662-8669
-
-
Liu, J.W.1
Sun, P.2
Yan, Q.3
Paller, A.S.4
Gerami, P.5
Ho, N.6
Vashi, N.7
le Poole, I.C.8
Wang, X.Q.9
-
219
-
-
84866058213
-
Immunoreactivity of the 14F7 Mab (raised against N-glycolyl GM3 Ganglioside) as a positive prognostic factor in non-small-cell lung cancer
-
Blanco, R.; Rengifo, C. E.; Cedeno, M.; Frometa, M.; Rengifo, E.; Carr, A. Immunoreactivity of the 14F7 Mab (raised against N-glycolyl GM3 Ganglioside) as a positive prognostic factor in non-small-cell lung cancer. Pathol. Res. Int. 2012, 2012, 235418.
-
(2012)
Pathol. Res. Int
, vol.2012
, pp. 235418
-
-
Blanco, R.1
Rengifo, C.E.2
Cedeno, M.3
Frometa, M.4
Rengifo, E.5
Carr, A.6
-
220
-
-
84872673776
-
Immunoreactivity of the 14F7 mab raised against N-glycolyl GM3 ganglioside in epithelial malignant tumors from digestive system
-
Blanco, R.; Rengifo, E.; Cedeno, M.; Rengifo, C. E.; Alonso, D. F.; Carr, A. Immunoreactivity of the 14F7 mab raised against N-glycolyl GM3 ganglioside in epithelial malignant tumors from digestive system. ISRN Gastroenterol. 2011, 2011, 645641.
-
(2011)
ISRN Gastroenterol
, vol.2011
, pp. 645641
-
-
Blanco, R.1
Rengifo, E.2
Cedeno, M.3
Rengifo, C.E.4
Alonso, D.F.5
Carr, A.6
-
221
-
-
0033624355
-
A mouse IgG1 monoclonal antibody specific for N-glycolyl GM3 ganglioside recognized breast and melanoma tumors
-
Carr, A.; Mullet, A.; Mazorra, Z.; Vazquez, A. M.; Alfonso, M.; Mesa, C.; Rengifo, E.; Perez, R.; Fernandez, L. E. A mouse IgG1 monoclonal antibody specific for N-glycolyl GM3 ganglioside recognized breast and melanoma tumors. Hybridoma 2000, 19, 241-247.
-
(2000)
Hybridoma
, vol.19
, pp. 241-247
-
-
Carr, A.1
Mullet, A.2
Mazorra, Z.3
Vazquez, A.M.4
Alfonso, M.5
Mesa, C.6
Rengifo, E.7
Perez, R.8
Fernandez, L.E.9
-
222
-
-
0023025941
-
Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor
-
Bremer, E. G.; Schlessinger, J.; Hakomori, S. Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor. J. Biol. Chem. 1986, 261, 2434-2440.
-
(1986)
J. Biol. Chem
, vol.261
, pp. 2434-2440
-
-
Bremer, E.G.1
Schlessinger, J.2
Hakomori, S.3
-
223
-
-
84872256078
-
Detection of N-glycolyated gangliosides in non-small-cell lung cancer using GMR8 monoclonal antibody
-
Hayashi, N.; Chiba, H.; Kuronuma, K.; Go, S.; Hasegawa, Y.; Takahashi, M.; Gasa, S.; Watanabe, A.; Hasegawa, T.; Kuroki, Y.; et al. Detection of N-glycolyated gangliosides in non-small-cell lung cancer using GMR8 monoclonal antibody. Cancer Sci. 2013, 104, 43-47.
-
(2013)
Cancer Sci
, vol.104
, pp. 43-47
-
-
Hayashi, N.1
Chiba, H.2
Kuronuma, K.3
Go, S.4
Hasegawa, Y.5
Takahashi, M.6
Gasa, S.7
Watanabe, A.8
Hasegawa, T.9
Kuroki, Y.10
-
224
-
-
0023893097
-
A novel ganglioside, de-N-acetyl-GM3 (II3NeuNH2LacCer), acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth
-
Hanai, N.; Dohi, T.; Nores, G. A.; Hakomori, S. A novel ganglioside, de-N-acetyl-GM3 (II3NeuNH2LacCer), acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth. J. Biol. Chem. 1988, 263, 6296-6301.
-
(1988)
J. Biol. Chem
, vol.263
, pp. 6296-6301
-
-
Hanai, N.1
Dohi, T.2
Nores, G.A.3
Hakomori, S.4
-
225
-
-
36148960809
-
EGFR inhibitor-mediated apoptosis in solid tumors
-
Goel, S.; Hidalgo, M.; Perez-Soler, R. EGFR inhibitor-mediated apoptosis in solid tumors. J. Exp. Ther. Oncol. 2007, 6, 305-320.
-
(2007)
J. Exp. Ther. Oncol
, vol.6
, pp. 305-320
-
-
Goel, S.1
Hidalgo, M.2
Perez-Soler, R.3
-
226
-
-
0029916780
-
Role of verotoxin receptors in pathogenesis
-
Lingwood, C. A. Role of verotoxin receptors in pathogenesis. Trends Microbiol. 1996, 4, 147-153.
-
(1996)
Trends Microbiol
, vol.4
, pp. 147-153
-
-
Lingwood, C.A.1
-
227
-
-
3242747908
-
Monoclonal antibody against a Burkitt lymphoma-associated antigen
-
Wiels, J.; Fellous, M.; Tursz, T. Monoclonal antibody against a Burkitt lymphoma-associated antigen. Proc. Natl. Acad. Sci. USA 1981, 78, 6485-6488.
-
(1981)
Proc. Natl. Acad. Sci. USA
, vol.78
, pp. 6485-6488
-
-
Wiels, J.1
Fellous, M.2
Tursz, T.3
-
228
-
-
69949083601
-
Shiga toxin receptor Gb3Cer/CD77: Tumor-association and promising therapeutic target in pancreas and colon cancer
-
Distler, U.; Souady, J.; Hulsewig, M.; Drmic-Hofman, I.; Haier, J.; Friedrich, A. W.; Karch, H.; Senninger, N.; Dreisewerd, K.; Berkenkamp, S.; et al. Shiga toxin receptor Gb3Cer/CD77: Tumor-association and promising therapeutic target in pancreas and colon cancer. PLoS One 2009, 4, e6813.
-
(2009)
PLoS One
, vol.4
-
-
Distler, U.1
Souady, J.2
Hulsewig, M.3
Drmic-Hofman, I.4
Haier, J.5
Friedrich, A.W.6
Karch, H.7
Senninger, N.8
Dreisewerd, K.9
Berkenkamp, S.10
-
229
-
-
62249196067
-
Expression of verotoxin-1 receptor Gb3 in breast cancer tissue and verotoxin-1 signal transduction to apoptosis
-
Johansson, D.; Kosovac, E.; Moharer, J.; Ljuslinder, I.; Brannstrom, T.; Johansson, A.; Behnam-Motlagh, P. Expression of verotoxin-1 receptor Gb3 in breast cancer tissue and verotoxin-1 signal transduction to apoptosis. BMC Cancer 2009, 9, 67.
-
(2009)
BMC Cancer
, vol.9
, pp. 67
-
-
Johansson, D.1
Kosovac, E.2
Moharer, J.3
Ljuslinder, I.4
Brannstrom, T.5
Johansson, A.6
Behnam-Motlagh, P.7
-
230
-
-
77953294709
-
Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and β-catenin signaling
-
Liu, Y. Y.; Gupta, V.; Patwardhan, G. A.; Bhinge, K.; Zhao, Y.; Bao, J.; Mehendale, H.; Cabot, M. C.; Li, Y. T.; Jazwinski, S. M. Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and β-catenin signaling. Mol. Cancer 2010, 9, 145.
-
(2010)
Mol. Cancer
, vol.9
, pp. 145
-
-
Liu, Y.Y.1
Gupta, V.2
Patwardhan, G.A.3
Bhinge, K.4
Zhao, Y.5
Bao, J.6
Mehendale, H.7
Cabot, M.C.8
Li, Y.T.9
Jazwinski, S.M.10
-
231
-
-
0019966323
-
Neutral glycolipid antigens as developmental markers of mouse teratocarcinoma and early embryos: An immunologic and chemical analysis
-
Willison, K. R.; Karol, R. A.; Suzuki, A.; Kundu, S. K.; Marcus, D. M. Neutral glycolipid antigens as developmental markers of mouse teratocarcinoma and early embryos: An immunologic and chemical analysis. J. Immunol. 1982, 129, 603-609.
-
(1982)
J. Immunol
, vol.129
, pp. 603-609
-
-
Willison, K.R.1
Karol, R.A.2
Suzuki, A.3
Kundu, S.K.4
Marcus, D.M.5
-
232
-
-
84860993482
-
Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor
-
Park, S. Y.; Kwak, C. Y.; Shayman, J. A.; Kim, J. H. Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor. Biochim. Biophys. Acta 2012, 1820, 1141-1148.
-
(2012)
Biochim. Biophys. Acta
, vol.1820
, pp. 1141-1148
-
-
Park, S.Y.1
Kwak, C.Y.2
Shayman, J.A.3
Kim, J.H.4
-
233
-
-
68149091582
-
Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer
-
Ruckhaberle, E.; Karn, T.; Rody, A.; Hanker, L.; Gatje, R.; Metzler, D.; Holtrich, U.; Kaufmann, M. Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer. J. Cancer Res. Clin. Oncol. 2009, 135, 1005-1013.
-
(2009)
J. Cancer Res. Clin. Oncol
, vol.135
, pp. 1005-1013
-
-
Ruckhaberle, E.1
Karn, T.2
Rody, A.3
Hanker, L.4
Gatje, R.5
Metzler, D.6
Holtrich, U.7
Kaufmann, M.8
-
234
-
-
33750596103
-
Fundamental study of small interfering RNAs for ganglioside GD3 synthase gene as a therapeutic target of lung cancers
-
Ko, K.; Furukawa, K.; Takahashi, T.; Urano, T.; Sanai, Y.; Nagino, M.; Nimura, Y.; Furukawa, K. Fundamental study of small interfering RNAs for ganglioside GD3 synthase gene as a therapeutic target of lung cancers. Oncogene 2006, 25, 6924-6935.
-
(2006)
Oncogene
, vol.25
, pp. 6924-6935
-
-
Ko, K.1
Furukawa, K.2
Takahashi, T.3
Urano, T.4
Sanai, Y.5
Nagino, M.6
Nimura, Y.7
Furukawa, K.8
-
235
-
-
34247154933
-
A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells
-
Wada, T.; Hata, K.; Yamaguchi, K.; Shiozaki, K.; Koseki, K.; Moriya, S.; Miyagi, T. A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells. Oncogene 2007, 26, 2483-2490.
-
(2007)
Oncogene
, vol.26
, pp. 2483-2490
-
-
Wada, T.1
Hata, K.2
Yamaguchi, K.3
Shiozaki, K.4
Koseki, K.5
Moriya, S.6
Miyagi, T.7
-
236
-
-
84859857694
-
VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma
-
Mikhaylova, O.; Stratton, Y.; Hall, D.; Kellner, E.; Ehmer, B.; Drew, A. F.; Gallo, C. A.; Plas, D. R.; Biesiada, J.; Meller, J.; et al. VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma. Cancer Cell 2012, 21, 532-546.
-
(2012)
Cancer Cell
, vol.21
, pp. 532-546
-
-
Mikhaylova, O.1
Stratton, Y.2
Hall, D.3
Kellner, E.4
Ehmer, B.5
Drew, A.F.6
Gallo, C.A.7
Plas, D.R.8
Biesiada, J.9
Meller, J.10
-
237
-
-
0036678137
-
Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression
-
Kakugawa, Y.; Wada, T.; Yamaguchi, K.; Yamanami, H.; Ouchi, K.; Sato, I.; Miyagi, T. Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression. Proc. Natl. Acad. Sci. USA 2002, 99, 10718-10723.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 10718-10723
-
-
Kakugawa, Y.1
Wada, T.2
Yamaguchi, K.3
Yamanami, H.4
Ouchi, K.5
Sato, I.6
Miyagi, T.7
-
238
-
-
81855222102
-
Membrane sialidase NEU3 is highly expressed in human melanoma cells promoting cell growth with minimal changes in the composition of gangliosides
-
Miyata, M.; Kambe, M.; Tajima, O.; Moriya, S.; Sawaki, H.; Hotta, H.; Kondo, Y.; Narimatsu, H.; Miyagi, T.; Furukawa, K.; et al. Membrane sialidase NEU3 is highly expressed in human melanoma cells promoting cell growth with minimal changes in the composition of gangliosides. Cancer Sci. 2011, 102, 2139-2149.
-
(2011)
Cancer Sci
, vol.102
, pp. 2139-2149
-
-
Miyata, M.1
Kambe, M.2
Tajima, O.3
Moriya, S.4
Sawaki, H.5
Hotta, H.6
Kondo, Y.7
Narimatsu, H.8
Miyagi, T.9
Furukawa, K.10
-
239
-
-
84856707555
-
Plasma membrane-associated sialidase (NEU3) regulates progression of prostate cancer to androgen-independent growth through modulation of androgen receptor signaling
-
Kawamura, S.; Sato, I.; Wada, T.; Yamaguchi, K.; Li, Y.; Li, D.; Zhao, X.; Ueno, S.; Aoki, H.; Tochigi, T.; et al. Plasma membrane-associated sialidase (NEU3) regulates progression of prostate cancer to androgen-independent growth through modulation of androgen receptor signaling. Cell Death Differ. 2012, 19, 170-179.
-
(2012)
Cell Death Differ
, vol.19
, pp. 170-179
-
-
Kawamura, S.1
Sato, I.2
Wada, T.3
Yamaguchi, K.4
Li, Y.5
Li, D.6
Zhao, X.7
Ueno, S.8
Aoki, H.9
Tochigi, T.10
-
240
-
-
84873305472
-
NEU3 sialidase is activated under hypoxia and protects skeletal muscle cells from apoptosis through the activation of the epidermal growth factor receptor signaling pathway and the hypoxia-inducible factor (HIF)-1α
-
Scaringi, R.; Piccoli, M.; Papini, N.; Cirillo, F.; Conforti, E.; Bergante, S.; Tringali, C.; Garatti, A.; Gelfi, C.; Venerando, B.; et al. NEU3 sialidase is activated under hypoxia and protects skeletal muscle cells from apoptosis through the activation of the epidermal growth factor receptor signaling pathway and the hypoxia-inducible factor (HIF)-1α. J. Biol. Chem. 2013, 288, 3153-3162.
-
(2013)
J. Biol. Chem
, vol.288
, pp. 3153-3162
-
-
Scaringi, R.1
Piccoli, M.2
Papini, N.3
Cirillo, F.4
Conforti, E.5
Bergante, S.6
Tringali, C.7
Garatti, A.8
Gelfi, C.9
Venerando, B.10
-
241
-
-
40849088147
-
Roles of plasma membrane-associated sialidase NEU3 in human cancers
-
Miyagi, T.; Wada, T.; Yamaguchi, K. Roles of plasma membrane-associated sialidase NEU3 in human cancers. Biochim. Biophys. Acta 2008, 1780, 532-537.
-
(2008)
Biochim. Biophys. Acta
, vol.1780
, pp. 532-537
-
-
Miyagi, T.1
Wada, T.2
Yamaguchi, K.3
-
242
-
-
23944504766
-
Evidence for mitochondrial localization of a novel human sialidase (NEU4)
-
Yamaguchi, K.; Hata, K.; Koseki, K.; Shiozaki, K.; Akita, H.; Wada, T.; Moriya, S.; Miyagi, T. Evidence for mitochondrial localization of a novel human sialidase (NEU4). Biochem. J. 2005, 390, 85-93.
-
(2005)
Biochem. J
, vol.390
, pp. 85-93
-
-
Yamaguchi, K.1
Hata, K.2
Koseki, K.3
Shiozaki, K.4
Akita, H.5
Wada, T.6
Moriya, S.7
Miyagi, T.8
-
243
-
-
3543110881
-
Apoptosis of human carcinoma cells in the presence of inhibitors of glycosphingolipid biosynthesis: I. Treatment of Colo-205 and SKBR3 cells with isomers of PDMP and PPMP
-
Basu, S.; Ma, R.; Mikulla, B.; Bradley, M.; Moulton, C.; Basu, M.; Banerjee, S.; Inokuchi, J. Apoptosis of human carcinoma cells in the presence of inhibitors of glycosphingolipid biosynthesis: I. Treatment of Colo-205 and SKBR3 cells with isomers of PDMP and PPMP. Glycoconj. J. 2004, 20, 157-168.
-
(2004)
Glycoconj. J
, vol.20
, pp. 157-168
-
-
Basu, S.1
Ma, R.2
Mikulla, B.3
Bradley, M.4
Moulton, C.5
Basu, M.6
Banerjee, S.7
Inokuchi, J.8
-
244
-
-
79952028218
-
The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function
-
Chai, L.; McLaren, R. P.; Byrne, A.; Chuang, W. L.; Huang, Y.; Dufault, M. R.; Pacheco, J.; Madhiwalla, S.; Zhang, X.; Zhang, M.; et al. The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function. Int. J. Oncol. 2011, 38, 701-711.
-
(2011)
Int. J. Oncol
, vol.38
, pp. 701-711
-
-
Chai, L.1
McLaren, R.P.2
Byrne, A.3
Chuang, W.L.4
Huang, Y.5
Dufault, M.R.6
Pacheco, J.7
Madhiwalla, S.8
Zhang, X.9
Zhang, M.10
-
245
-
-
32144447613
-
Suppression of glucosylceramide synthase by RNA interference reverses multidrug resistance in human breast cancer cells
-
Sun, Y. L.; Zhou, G. Y.; Li, K. N.; Gao, P.; Zhang, Q. H.; Zhen, J. H.; Bai, Y. H.; Zhang, X. F. Suppression of glucosylceramide synthase by RNA interference reverses multidrug resistance in human breast cancer cells. Neoplasma 2006, 53, 1-8.
-
(2006)
Neoplasma
, vol.53
, pp. 1-8
-
-
Sun, Y.L.1
Zhou, G.Y.2
Li, K.N.3
Gao, P.4
Zhang, Q.H.5
Zhen, J.H.6
Bai, Y.H.7
Zhang, X.F.8
-
246
-
-
84855303523
-
Sphingosine-1-phosphate signaling and its role in disease
-
Maceyka, M.; Harikumar, K. B.; Milstien, S.; Spiegel, S. Sphingosine-1-phosphate signaling and its role in disease. Trends Cell Biol. 2012, 22, 50-60.
-
(2012)
Trends Cell Biol
, vol.22
, pp. 50-60
-
-
Maceyka, M.1
Harikumar, K.B.2
Milstien, S.3
Spiegel, S.4
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