Identification of a family of animal sphingomyelin synthases

EMBO Journal

Volumn 23, Issue 1, 2004, Pages 33-44

  Huitema, Klazien ^a   Van Den Dikkenberg, Joep ^a   Brouwers, Jos F H M ^b   Holthuis, Joost C M ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Apoptosis; Ceramide; Golgi; Lipid phosphate phosphatase; Sphingomyelin synthase

Indexed keywords

CERAMIDE; DIACYLGLYCEROL; MEMBRANE PROTEIN; PHOSPHATIDYLCHOLINE; PHOSPHORYLCHOLINE; SPHINGOLIPID; SPHINGOMYELIN; SPHINGOMYELIN SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CAENORHABDITIS ELEGANS; CATALYSIS; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME LOCALIZATION; ENZYME SYNTHESIS; GOLGI COMPLEX; HUMAN; HUMAN CELL; LIPID TRANSPORT; LIPOGENESIS; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; SIGNAL TRANSDUCTION; YEAST;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CELL MEMBRANE; CLONING, MOLECULAR; COMPUTATIONAL BIOLOGY; CONSENSUS SEQUENCE; CONSERVED SEQUENCE; DATABASES, FACTUAL; GOLGI APPARATUS; HELA CELLS; HUMANS; HYDROPHOBICITY; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; SPHINGOMYELINS; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS;

EID: 0842263750     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600034     Document Type: Article

References (40)

1. Andrieu-Abadie N, Levade T (2002) Sphingomyelin hydrolysis during apoptosis. Biochim Biophys Acta 1585: 126-134
2. Bankaitis VA (2002) Cell biology Slick recruitment to the Golgi. Science 295: 290-291
3. Bourteele S, Hausser A, Doppler H, Horn-Muller J, Ropke C, Schwarzmann G, Pfizenmaier K, Muller G (1998) Tumor necrosis factor induces ceramide oscillations and negatively controls sphingolipid synthases by caspases in apoptotic Kym-1 cells. J Biol Chem 273: 31245-31251
4. Brauer AU, Savaskan NE, Kuhn H, Prehn S, Ninnemann O, Nitsch R (2003) A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. Nat Neurosci 6: 572-578
5. Brose N, Rosenmund C (2002) Move over protein kinase C, you've got company. J Cell Sci 115: 4399-4411
6. Brouwers JF, Gadella BM, van Golde LM, Tielens AG (1998) Quantitative analysis of phosphatidylcholine molecular species using HPLC and light scattering detection. J Lipid Res 39: 344-353
7. Dickson RC (1998) Sphingolipid functions in Saccharomyces cerevisiae: comparison to mammals. Annu Rev Biochem 67: 27-48
8. Elmendorf HG, Haldar K (1994) Plasmodium falciparum exports the Golgi marker sphingomyelin synthase into a tubovesicular network in the cytoplasm of mature erythrocytes. J Cell Biol 124: 449-462
9. Fukasawa M, Nishijima M, Hanada K (1999) Genetic evidence for ATP-dependent ER-to-Golgi apparatus trafficking of ceramide for sphingomyelin synthesis in CHO cells. J Cell Biol 144: 673-685
10. Futerman AH, Stieger B, Hubbard AL, Pagano RE (1990) Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus. J Biol Chem 265: 8650-8657
11. Gommel D, Orci L, Emig EM, Hannah MJ, Ravazzola M, Nickel W, Helms JB, Wieland FT, Sohn K (1999) p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway. FEBS Lett 447: 179-185
12. Hanada K, Hara T, Fukasawa M, Yamaji A, Umeda M, Nishijima M (1998) Mammalian cell mutants resistant to a sphingomyelin-directed cytolysin. J Biol Chem 273: 33787-33794
13. Heidler SA, Radding JA (2000) Inositol phosphoryl transferases from human pathogenic fungi. Biochim Biophys Acta 1500: 147-152
14. Holthuis JCM, Nichols BJ, Dhruvakumar S, Pelham HR (1998) Two syntaxin homologues in the TGN/endosomal system of yeast. EMBO J 17: 113-126
15. Holthuis JCM, Pomorski T, Raggers RJ, Sprong H, Van Meer G (2001) The organizing potential of sphingolipids in intracellular membrane transport. Physiol Rev 81: 1689-1723
16. Jeckel D, Karrenbauer A, Birk R, Schmidt RR, Wieland F (1990) Sphingomyelin is synthesized in the cis Golgi. FEBS Lett 261: 155-157
17. Kallen K-J, Allan D, Whatmore J, Quinn P (1994) Synthesis of surface sphingomyelin in the plasma membrane recycling pathway of BHK Cells. Biochim Biophys Acta 1191: 52-58
18. Kolesnick R, Hannun YA (1999) Ceramide and apoptosis. Trends Biochem Sci 24: 224-225
19. Lauer SA, Ghori N, Haldar K (1995) Sphingolipid synthesis as a target for chemotherapy against malaria parasites. Proc Natl Acad Sci USA 92: 9181-9185
20. Levine TP, Wiggins CA, Munro S (2000) Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae. Mol Biol Cell 11: 2267-2281
21. Lipsky NG, Pagano RE (1985) Intracellular translocation of fluorescent sphingolipids in cultured fibroblasts. J Cell Biol 100: 27-34
22. Luberto C, Hannun YA (1998) Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. J Biol Chem 273: 14550-14559
23. Luberto C, Stonehouse MJ, Collins EA, Marchesini N, El-Bawab S, Vasil AI, Vasil ML, Hannun YA (2003) Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. J Biol Chem 278: 32733-32743
24. Malgat M, Maurice A, Baraud J (1986) Sphingomyelin and ceramide-phosphoethanolamine synthesis by microsomes and plasma membranes from rat liver and brain. J Lipid Res 27: 251-260
25. Marggraf WD, Anderer FA, Kanfer JN (1981) The formation of sphingomyelin from phosphatidylcholine in plasma membrane preparations from mouse fibroblasts. Biochim Biophys Acta 664: 61-73
26. Marggraf W-D, Kanfer JN (1984) The phosphorylcholine receptor in the phosphatidylcholine:ceramide cholinephosphotransferase reaction. Biochim Biophys Acta 793: 346-353
27. Nagiec MM, Nagiec EE, Baltisberger JA, Wells GB, Lester RL, Dickson RC (1997) Sphingolipid synthesis as a target for antifungal drugs. J Biol Chem 272: 9809-9817
28. Neuwald AF (1997) An unexpected structural relationship between integral membrane phosphatases and soluble haloperoxidases. Protein Sci 6: 1764-1767
29. Pettus BJ, Chalfant CE, Hannun YA (2002) Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta 1585:114-125
30. Riboni L, Viani P, Bassi R, Giussani P, Tettamanti G (2001) Basic fibroblast growth factor-induced proliferation of primary astrocytes. J Biol Chem 276: 12797-12804
31. Rietveld A, Neutz S, Simons K, Eaton S (1999) Association of sterol-and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains. J Biol Chem 274: 12049-12054
32. Satouchi K, Hirano K, Sakaguchi M, Takehara H, Matsuura F (1993) Phospholipids from the free-living nematode Caenorhabditis elegans. Lipids 28: 837-840
33. Schultz J, Ponting CP, Hofmann K, Bork P (1997) SAM as a protein interaction domain involved in developmental regulation. Protein Sci 6: 249-253
34. Simons K, Toomre D (2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1: 31-39
35. Trotter PJ (2000) A novel pathway for transport and metabolism of a fluorescent phosphatidic acid analog in yeast. Traffic 1: 425-434
36. Ullman MD, Radin NS (1974) The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver. J Biol Chem 249: 1506-1512
37. van Helvoort A, Stoorvogel W, van Meer G, Burger KNJ (1997) Sphingomyelin synthase is absent from endosomes. J Cell Sci 110: 781-788
38. van Helvoort A, van't Hof W, Ritsema T, Sandra A, van Meer G (1994) Conversion of diacylglycerol to phosphatidylcholine on the basolateral surface of epithelial MDCK cells. J Biol Chem 269: 1763-1769
39. Voelker DR, Kennedy EP (1982) Cellular and enzymic synthesis of sphingomyelin. Biochemistry 21: 2753-2759
40. Waggoner DW, Xu J, Singh I, Jasinska R, Zhang QX, Brindley DN (1999) Structural organization of mammalian lipid phosphate phosphatases: implications for signal transduction. Biochim Biophys Acta 1439: 299-316