Sphingolipid metabolism enzymes as targets for anticancer therapy

Current Drug Targets

Volumn 5, Issue 4, 2004, Pages 375-382

  Kok, J W ^a   Sietsma, H ^b  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Ceramide; Gangliosides; Glucosylceramide; Lactosylceramide; Multidrug resistance; P glycoprotein; Sphingolipid; Synthase

Indexed keywords

2 DECANOYLAMINO 3 MORPHOLINO 1 PHENYL 1 PROPANOL; ABC TRANSPORTER; ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; CERAMIDE; CERAMIDE GLUCOSYLTRANSFERASE; CERAMIDE GLUCOSYLTRANSFERASE INHIBITOR; CYCLOSPORIN A; CYTOSTATIC AGENT; DAUNORUBICIN; DOXORUBICIN; DRUG METABOLIZING ENZYME; GLUCOSYLCERAMIDE; GLYCOPROTEIN P INHIBITOR; INHIBITOR OF APOPTOSIS PROTEIN; IRINOTECAN; MULTIDRUG RESISTANCE PROTEIN; PACLITAXEL; PALMITOYL COENZYME A; PHOSPHOPROTEIN PHOSPHATASE 2A; SERINE PALMITOYLTRANSFERASE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE ACYLTRANSFERASE; SPHINGOSINE KINASE; TAMOXIFEN; UNINDEXED DRUG; VALSPODAR; VERAPAMIL; VINCRISTINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BREAST TUMOR; CANCER RESEARCH; CELL DEATH; CELL METABOLISM; CELL SURVIVAL; CELL TYPE; COLORECTAL CANCER; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG TARGETING; ENZYME INHIBITION; HUMAN; LIPID METABOLISM; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PROSTATE CANCER; PROTEIN GLYCOSYLATION; REVIEW; SIDE EFFECT; TUMOR CELL; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; DRUG DELIVERY SYSTEMS; HUMANS; NEOPLASMS; SPHINGOLIPIDS;

EID: 2342437213     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389450043345452     Document Type: Review

References (81)

1. Eckhardt, S. (2002) Curr. Med. Chem. 2, 419-439.
2. Abal, M.; Andrea, J.M. and Barasoain, I. (2003) Curr. Cancer Drug Targets 3, 193-203.
3. Los, M.; Burek, C.J.; Stroh, C.; Benedyk, K.; Hug, H. and Mackiewicz, A. (2003) Drug Discovery Today 8 (2), 67-77.
4. Hersey, P. and Zhang, X.D. (2003) J. Cell. Physiol. 196, 9-18.
5. Makin, G. and Dive, C. (2001) Trends Cell Biol. 11(11), s22-s26.
6. Ling, V.; Kartner, N.; Sudo, T.; Siminovitch, L. and Riordan, J.R. (1983) Cancer Treat. Rep. 67, 869-874.
7. Gottesman, M.M. (2002) Annu. Rev. Med. 53, 615-627.
8. Roepe, P.D. (1995) Biochim. Biophys. Acta 1241, 385-406.
9. Higgins, C.F. and Gottesman, M.M. (1992) Trends. Biochem. Sci. 17, 18-21.
10. Tiirikainen, M.I.; Elonen, E.; Syrjala, M.T.; Jansson, S.E. and Krusius, T. (1994) Leukemia 8, 978-984.
11. Friche, E.; Danks, M.K.; Schmidt, C.A. and Beck, W.T. (1991) Cancer Res. 51, 4213-4218.
12. Topcy, Z (2001) J. Clin. Pharm. Ther. 26(6), 405-416.
13. Yusuf, R.Z.; Duan, Z.; Lamendoal, D.E.; Penson, R.T. and Seiden, M.V. (2003) Curr. Cancer Drug Targets 3(1), 1-19.
14. Lazaris, A.C.; Kavantzas, N.G.; Zorzos, H.S.; Tsavaris, N.V. and Davaris, P.S. (2002) J. Cancer Res. Clin. Oncol. 128(2), 114-118.
15. Levenson, V.V.; Davidovich, I.A. and Roninson, I.B. (2000) Cancer Res. 60, 5027-5030.
16. Merrill, A.H. Jr. and Sandhoff, K (2002) in New comprehensive biochemistry: biochemistry of lipids, lipoproteins and membranes, (Vance, D.E and Vance, J.E. Eds.), Elsevier Science, Amsterdam, pp. 373-407.
17. Futerman, A.H. and Pagano, R.E. (1991) Biochem. J. 280, 295-302.
18. van Meer, G. and Holthuis, J.C.M. (2000) Biochim. Biophys. Acta 1486, 145-170.
19. van Echten, G. and Sandhoff, K. (1993) J. Biol. Chem. 268, 5341-5344.
20. Shayman, J.A. and Abe, A. (2000) Methods Enzymol. 311, 105-117.
21. Ohanian, J. and Ohanian V. (2001) Cell Mol. Life Sci. 58(14), 2053-2068.
22. Jenkins, G.M. (2003) Cell Mol. Life Sci. 60(4), 701-710.
23. Spiegel, S, and Milstien, S (2003) Nat. Rev. Mol. Cell Biol. 4(5), 397-407.
24. Hannun, Y.A. and Obeid, L.M. (2002) J. Biol. Chem. 277(29), 25847-25850.
25. Cuvillier, O. (2002) Biochim. Biophys. Acta 1585, 153-162.
26. Maceyka, M.; Payne, S.G.; Milstien, S. and Spiegel, S. (2002) Biochim. Biophys. Acta 1585, 193-201.
27. Malisan, F. and Testi, R. (2002) Biochim. Biophys. Acta 1585, 179-187.
28. Luberto, C.; Kraveka, J.M. and Hannun, Y.A. (2002) Neurochem. Res. 27(7/8), 609-617.
29. Pettus, B.J.; Chalfant, C.E. and Hannun, Y.A. (2002) Biochim. Biophys. Acta 1585, 114-125.
30. Bose, R.; Verheij, M.; Haimovitz Friedman, A.; Seotto, K.; Fuks, Z. and Kolesnick, R. (1995) Cell 82, 405-414.
31. Jaffrezou, J.P.; Levade, T.; Bettaieb, A.; Andrieu, N.; Bezombes, C.; Maestre, N.; Vermeersch, S.; Rousse, A. and Laurent, G. (1996) EMBO J. 15, 2417-2424.
32. Bleicher, R.J. and Cabot, M.C. (2002) Biochim. Biophys. Acta 1585, 172-178.
33. Senchenkov, A.; Litvak, D.A. and Cabot, M.C. (2001) J. Natl. Cancer Inst. 93(5), 347-357.
34. Ogretmen, B and Hannun, Y.A. (2002) Drug Resistance Updates 4, 368-377.
35. Lavie, Y.; Cao, H.; Bursten, S.L.; Giuliano, A.E. and Cabot, M.C. (1996) J. Biol. Chem. 271, 19530-19536.
36. Lucci, A.; Cho, W.I.; Han, T.Y.; Giuliano, A.E.; Morton, D.L. and Cabot, M.C. (1998) Anticancer Res. 18, 475-480.
37. Kok, J.W.; Veldman, R.J.; Klappe, K.; Koning, H.; Filipeanu, C.M. and Muller, M. (2000) Int. J. Cancer 87, 172-178.
38. van Helvoort, A.; Smith, A.J.; Sprong, H.; Fritsche, I.; Schinkel, A.H.; Borst, P. and van Meer, G. (1996) Cell 87, 507-517.
39. Borst, P.; Zelcer, N. and van Helvoort, A. (2000) Biochim. Biophys. Acta 1486, 128-144.
40. Raggers, R.J.; van Helvoort, A.; Evers, R. and van Meer, G. (1999) J.Cell Sci. 112, 415-422.
41. Sietsma, H.; Veldman, R.J. and Kok, J.W. (2001) J. Membr. Biol. 181, 153-162.
42. Lala, P.; Ito, S. and Lingwood, C.A. (2000) J. Biol. Chem. 275, 6246-6251.
43. Shabbits, J.A. and Mayer, L.D. (2002) Mol. Cancer Ther. 1, 205-213.
44. Sietsma, H.; Dijkhuis, A.J.; Kamps, W. and Kok, J.W. (2002) Neurochem. Res. 27(7/8), 665-674.
45. Demeule, M.; Jodoin, J.; Gingras, D. and Beliveau, R. (2000) FEBS Lett. 466, 219-224.
46. Lavie, Y.; Fiucci, G.; and Liscovitch, M. (1998) J. Biol. Chem. 273, 32380-32383.
47. Lavie, Y.; Fiucci, G.; Czarny, M. and Liscovitch, M. (1999) Lipids 34 Suppl, S57-63.
48. Yang, C.P.; Galbiati, F.; Volonte, D; Horwitz, S.B. and Lisanti, M.P. (1998) FEBS Lett. 439, 368-372.
49. Veldman, R.J.; Klappe, K.; Hinrichs, J.W.J.; Hummel, I., van der Schaaf, G.; Sietsma, H. and Kok, J.W. (2002) FASEB J. 10.1096/fj.01-0863fje.
50. Liu, Y.Y.; Han, T.Y.; Giuliano, A.E. and Cabot, M.C. (1999) J. Biol. Chem. 274, 1140-1146.
51. Liu, Y.Y.; Han, T.Y.; Giuliano, A.E.; Hansen, N. and Cabot, M.C. (2000) J. Biol. Chem. 275, 7138-7143.
52. Lavie, Y.; Cao H.; Volner, A.; Lucci, A.; Han, T.Y.; Geffen, V.; Giuliano, A.E. and Cabot, M.C. (1997) J. Biol. Chem. 272, 1682-1687.
53. Lee, L.; Abe, A. and Shayman, J.A. (1999) J. Biol. Chem. 274(21), 14662-14669.
54. Shayman, J.A.; Lee, L.; Abe, A. and Shu, L. (2000) Meth. Enzymol. 311, 373-387.
55. Nicholson, K.M.; Quinn, D.M.; Kellett, G.L. and Warr, J.R. (1999) Br. J. Cancer 81, 423-430.
56. Sietsma, H.; Veldman, R.J.; Kolk, D.; Ausema, B.; Nijhof, W.; Kamps, W.A.; Vellenga, E. and Kok, J.W. (2000) Clin. Cancer Res. 6, 942-948.
57. Olshefski, R.S. and Ladish, S. (2001) Int. J. Cancer 93, 131-138.
58. Radin, N.S. (2003) Biochem. J. 371, 243-256.
59. Wang, H.; Charles, A.G.; Frankel, A.J. and Cabot, M.C. (2003) Urology 61(5), 1047-1052.
60. Litvak, D.A.; Bilchik, A.J. and Cabot, M.C. (2003) J. Gastrointestinal Surg. 7, 140-148.
61. Kok, J.W.; Babia, T.; Egea, G. and Hoekstra, D. (1998) J. Cell Biol. 142, 25-38.
62. Di Sano, F; Di Bartolomeo, S; Fazi, B; Fiorentini, C; Mataresse, P; Spinedi, A. and Piacentini, M. (2002) Cell Death Differ. 9, 693-695.
63. Di Sano, F; Fazi, B; Citro, G.; Lovat, P.E.; Cesareni, G. and Piacentini, M. (2003) Cancer Res. 963, 3860-3865.
64. Oertle, T. and Schwab, M.E. (2003) Trends Cell Biol. 13(4), 187-194.
65. Tagami, S.; Eguchi, Y.; Kinoshita, M.; Takeda, M. and Tsujimoto, Y. (2000) Oncogene 19(50), 5736-5746.
66. Ichikawa, S.; Nakajo, N.; Sakiyama, H. and Hirabayashi, Y. (1994) Proc. Natl. Acad Sci. USA 91, 2703-2707.
67. Komori, H.; Ichikawa, S.; Hirabayashi, Y. and Ito, M. (1999) J. Biol. Chem. 274, 8981-8987.
68. Veldman, R.J.; Mita, A.; Cuvillier, O.; Garcia, V.; Klappe, K.; Medin, J.A.; Campbell, J.D.; Carpentier, S.; Kok, J.W. and Levade, T.(2003) FASEB J. l0.1096/fj.02-1053fje.
69. Hidari, K.I.P.J.; Ichikawa, S.; Fujita, T.; Sakiyama, H. and Hirabayashi, Y. (1996) J. Biol. Chem. 271(24), 14636-14641.
70. Itoh, M.; Kitano, T.; Watanabe, M.; Kondo, T.; Yabu, T.; Taguchi, Y.; Iwai, K.; Tashima, M.; Uchiyama, T. and Okazaki, T. (2003) Clin. Cancer Res. 9(1), 415-23.
71. Radin, N.S. (2001) Eur. J. Biochem. 268, 193-202.
72. Kester, M and Kolesnick, R. (2003) Pharmacol. Res. 47, 362-371.
73. Perry, D.K. and Kolesnick, R.N. (2003) Cancer Treat Res. 115, 345-354.
74. Giraudo, C.G. and Maccioni, H.J.F. (2003) J. Biol. Chem. 278(41), 40262-40271.
75. Giraudo, C.G.; Daniotti, J.L. and Maccioni, H.J. (2001) Proc. Natl. Acad. Sci. USA 98(4), 1625-1630.
76. Garcia-Ruiz, C.; Colell, A.; Morales, A.; Calvo, M.; Enrich, C. and Fernandez-Checa, J.C. (2002) J. Biol. Chem. 277(39), 36433-36448.
77. Paris, R.; Morales, A.; Coll, O.; Sanchez-Reyes, A.; Garcia-Ruiz, C. and Fernandez-Checa, J.C. (2002) J. Biol. Chem. 277(52), 49870-49876.
78. Garcia-Ruiz, C.; Colell, A.; Paris, R. and Fernandez-Checa, J.C. (2000) FASEB J. 14(7), 847-58.
79. Pio, I.; Lehne, G.; Beckstrom, K.J.; Maestre, N.; Bettaieb, A.; Laurent, G. and Lautier, D. (2002) Mol. Pharmacol. 62(2), 304-312.
80. Prinetti, A.; Basso, L.; Appierto, V.; Villani, M.G.; Valsecchi, M; Loberto, N.; Prioni, S.; Chigorno, V.; Cavadini, E.; Formelli, F. and Sonnino, S. (2003) J. Biol. Chem. 278(8), 5574-83.
81. Dijkhuis, A.-J.; Douwes, J.; Kamps, W.; Sietsma, H. and Kok, J.W. (2003) FEBS Lett. 548, 28-32.