Influence of ceramide metabolism on P-glycoprotein function in immature acute myeloid leukemia KG1a cells

Molecular Pharmacology

Volumn 62, Issue 2, 2002, Pages 304-312

  Plo, Isabelle ^a   Lehne, Gustav ^b   Beckstrøm, Karen Johanne ^b   Maestre, Nicolas ^a   Bettaïeb, Ali ^c   Laurent, Guy ^a,d   Lautier, Dominique ^a  

^a INSERM   (France)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c PSL RESEARCH UNIVERSITY   (France)

^d CHU PURPAN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 DECANOYLAMINO 3 MORPHOLINO 1 PHENYL 1 PROPANOL; CERAMIDE; CERAMIDE GLUCOSYLTRANSFERASE; DAUNORUBICIN; DISIALOGANGLIOSIDE; GANGLIOSIDE; GLYCOPROTEIN P; LACTOSYLCERAMIDE; MONOSIALOGANGLIOSIDE; RHODAMINE; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; CYTOTOXICITY; DRUG RETENTION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

EID: 0036073348     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.2.304     Document Type: Article

References (41)

1. Modulation of P-glycoprotein by protein kinase C α in a baculovirus expression system
2. Gangliosides in acute myeiold leukaemia (AML) and non-Hodgkin's lymphoma (NHL)
3. Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell lines
4. Reverse transformation of mnltidrug-resistant cells
5. A rapid method of total lipid extraction and purification
6. Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC α
7. SDZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synththesis and increases vinblastine sensitivity in drug-sensitive and drug-resistant cancer cells
8. Tamoxifen retards glycosphingolipid metabolism in human cancer cells
9. Clinical significance of multidrug resistance P-glycoprotein expression on acute non-lymphoblastic leukemia cells at diagnosis
10. Identification of specific sites in human P-glycoprotein phosphorylated by protein kinase C
11. Acute myeloid leukemia cells with low P-glycoprotein expression and high rhodamine 123 efflux capacity display high clonogenicity
12. Inhibition of P-glycoprotein activity in human leukemic cells by mifepristone
13. Differential expression and activity of P-glycoprotein and multidrug resistance-associated protein in CD34-positive KG1a leukemic cells
14. P-glycoprotein, multidrug resistance and protein kinase C
15. A simple method for the isolation and purification of total lipids from animal tissues
16. Biochemistry of multidrug resistance mediated by the multidrug transporter
17. Partial reversal of multidrug resistance in human breast cancer cells by an Nmyristoylated protein kinase C-α pseudosubstrate peptide
18. Functional roles of glycosphingolipids and sphingolipids in signal transduction
19. 6-fold increased cell sensitivity to verocytotoxin. Role of P-glycoprotein in glycolipid synthesis
20. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
21. Accumulation of glucosylceramides in multidrug-resistant cancer cells
22. Agents that reverse multidrug resistance, tamoxifen, verapamil and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells
23. Changes in membrane microdomains and caveolae constituents in multidrug resistant cancer cells
24. Up-regulation of caveolae and caveolar constituents in multidrug-resistant cancer cells
25. Diverse effects of P-glycoprotien inhibitory agents on human leukemia cells expressing the multidrug resistance protein (MRP)
26. Cytotoxic effect of the cyclosporin PSC 833 in multidrug resistant leukaemia cells with increased expression of P-glycoprotein
27. - cases
28. Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells
29. Uncoupling ceramide glycosylation by transfection of glucosylamide synthase antisense reverses adriamycin resistance
30. Glucosylceramide: A marker for multiple-drag resistant cancers
31. Modification of ceramide metabolism increases cancer cell sensitivity to cytotoxics
32. Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug-resistant cancer cells
33. Glucosylceramide synthase inhibitor inhibits the action of nerve growth factor in PC12 cells
34. Preferential killing of multidrug-resistant KB cells by inhibitors of glucosylceramide synthase
35. Glycosphingolipid-enriched signaling domain in mouse neuroblastoma Neuro2a cells. Mechanism of gangliosidedependant neuritogenesis
36. Metabolic effects of inhibiting glucosylceramide synthesis with PDMP and other substances
37. Gangliosides asymmetrically alter the membrane order in cultured PC-12 cells
38. Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C
39. Effects of sphingosine stereoisomers on P-glycoprotein phosphorylation and vinblastine accumulation in multidrug-resistant MCF-7 cells
40. 1-Phenyl-2-decanoylamino-3-morpholino-1-propanolol chemosensitizes neuroblastoma cells for taxol and vincristine
41. Inhibition of P-glycoprotein activity and chemosensitization of multidrug-resistant ovarian carcinoma 2780AD cells by hexanoylghicosylceramide