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Volumn 167, Issue 2, 2012, Pages 206-215

Immunology in the clinic review series; focus on cancer: Glycolipids as targets for tumour immunotherapy

Author keywords

Cancer vaccine; Glycolipid; Glycosylation; Immunotherapy; Monoclonal antibody

Indexed keywords

CA 19-9 ANTIGEN; CANCER VACCINE; GANGLIOSIDE GD2; GLYCOSPHINGOLIPID; MONOCLONAL ANTIBODY;

EID: 84855803916     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2011.04516.x     Document Type: Review
Times cited : (61)

References (112)
  • 1
    • 0036677372 scopus 로고    scopus 로고
    • Glycosylation defining cancer malignancy: new wine in an old bottle
    • Hakomori S. Glycosylation defining cancer malignancy: new wine in an old bottle. Proc Natl Acad Sci USA 2002; 99:10231-3.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10231-10233
    • Hakomori, S.1
  • 2
    • 0035421220 scopus 로고    scopus 로고
    • A monoclonal antibody that induces neuronal apoptosis binds a metastasis marker
    • Zhong LT, Manzi A, Skowronski E etal. A monoclonal antibody that induces neuronal apoptosis binds a metastasis marker. Cancer Res 2001; 61:5741-8.
    • (2001) Cancer Res , vol.61 , pp. 5741-5748
    • Zhong, L.T.1    Manzi, A.2    Skowronski, E.3
  • 3
    • 76249129507 scopus 로고    scopus 로고
    • Suppression of human prostate tumor growth by a unique prostate-specific monoclonal antibody F77 targeting a glycolipid marker
    • Zhang G, Zhang H, Wang Q etal. Suppression of human prostate tumor growth by a unique prostate-specific monoclonal antibody F77 targeting a glycolipid marker. Proc Natl Acad Sci USA 2010; 107:732-7.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 732-737
    • Zhang, G.1    Zhang, H.2    Wang, Q.3
  • 4
    • 34147140962 scopus 로고    scopus 로고
    • The glycotope-specific RAV12 monoclonal antibody induces oncosis in vitro and has antitumor activity against gastrointestinal adenocarcinoma tumor xenografts in vivo
    • Loo D, Pryer N, Young P etal. The glycotope-specific RAV12 monoclonal antibody induces oncosis in vitro and has antitumor activity against gastrointestinal adenocarcinoma tumor xenografts in vivo. Mol Cancer Ther 2007; 6:856-65.
    • (2007) Mol Cancer Ther , vol.6 , pp. 856-865
    • Loo, D.1    Pryer, N.2    Young, P.3
  • 5
    • 34848816597 scopus 로고    scopus 로고
    • Binding activities and antitumor properties of a new mouse/human chimeric antibody specific for GD2 ganglioside antigen
    • Alvarez-Rueda N, Leprieur S, Clemenceau B etal. Binding activities and antitumor properties of a new mouse/human chimeric antibody specific for GD2 ganglioside antigen. Clin Cancer Res 2007; 13:5613s-20s.
    • (2007) Clin Cancer Res , vol.13
    • Alvarez-Rueda, N.1    Leprieur, S.2    Clemenceau, B.3
  • 6
    • 0025218791 scopus 로고
    • Highly tumor-reactive, internalizing, mouse monoclonal antibodies to Le(y)-related cell surface antigens
    • Hellstrom I, Garrigues HJ, Garrigues U, Hellstrom KE. Highly tumor-reactive, internalizing, mouse monoclonal antibodies to Le(y)-related cell surface antigens. Cancer Res 1990; 50:2183-90.
    • (1990) Cancer Res , vol.50 , pp. 2183-2190
    • Hellstrom, I.1    Garrigues, H.J.2    Garrigues, U.3    Hellstrom, K.E.4
  • 7
    • 0032578387 scopus 로고    scopus 로고
    • A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence
    • Chou HH, Takematsu H, Diaz S etal. A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence. Proc Natl Acad Sci USA 1998; 95:11751-6.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11751-11756
    • Chou, H.H.1    Takematsu, H.2    Diaz, S.3
  • 9
    • 0032080795 scopus 로고    scopus 로고
    • Glucosylceramide synthase and glycosphingolipid synthesis
    • Ichikawa S, Hirabayashi Y. Glucosylceramide synthase and glycosphingolipid synthesis. Trends Cell Biol 1998; 8:198-202.
    • (1998) Trends Cell Biol , vol.8 , pp. 198-202
    • Ichikawa, S.1    Hirabayashi, Y.2
  • 10
    • 0032475872 scopus 로고    scopus 로고
    • UDP-galactose: ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum
    • Sprong H, Kruithof B, Leijendekker R, Slot JW, van Meer G, van der Sluijs P. UDP-galactose: ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum. J Biol Chem 1998; 273:25880-8.
    • (1998) J Biol Chem , vol.273 , pp. 25880-25888
    • Sprong, H.1    Kruithof, B.2    Leijendekker, R.3    Slot, J.W.4    van Meer, G.5    van der Sluijs, P.6
  • 11
    • 0028288399 scopus 로고
    • Lactosylceramide is synthesized in the lumen of the Golgi apparatus
    • Lannert H, Bunning C, Jeckel D, Wieland FT. Lactosylceramide is synthesized in the lumen of the Golgi apparatus. FEBS Lett 1994; 342:91-6.
    • (1994) FEBS Lett , vol.342 , pp. 91-96
    • Lannert, H.1    Bunning, C.2    Jeckel, D.3    Wieland, F.T.4
  • 12
    • 38449102577 scopus 로고    scopus 로고
    • Lactosylceramide: a lipid second messenger in neuroinflammatory disease
    • Won JS, Singh AK, Singh I. Lactosylceramide: a lipid second messenger in neuroinflammatory disease. J Neurochem 2007; 103 (Suppl. 1):180-91.
    • (2007) J Neurochem , vol.103 , Issue.1 SUPPL , pp. 180-191
    • Won, J.S.1    Singh, A.K.2    Singh, I.3
  • 13
    • 3843114549 scopus 로고    scopus 로고
    • Alterations in neuroblastoma ganglioside synthesis by induction of GD1b synthase by retinoic acid
    • Hettmer S, McCarter R, Ladisch S, Kaucic K. Alterations in neuroblastoma ganglioside synthesis by induction of GD1b synthase by retinoic acid. Br J Cancer 2004; 91:389-97.
    • (2004) Br J Cancer , vol.91 , pp. 389-397
    • Hettmer, S.1    McCarter, R.2    Ladisch, S.3    Kaucic, K.4
  • 14
    • 74849118341 scopus 로고    scopus 로고
    • Lipid rafts as a membrane-organizing principle
    • Lingwood D, Simons K. Lipid rafts as a membrane-organizing principle. Science 2010; 327:46-50.
    • (2010) Science , vol.327 , pp. 46-50
    • Lingwood, D.1    Simons, K.2
  • 15
    • 0032502722 scopus 로고    scopus 로고
    • GM3-enriched microdomain involved in cell adhesion and signal transduction through carbohydrate-carbohydrate interaction in mouse melanoma B16 cells
    • Iwabuchi K, Yamamura S, Prinetti A, Handa K, Hakomori S. GM3-enriched microdomain involved in cell adhesion and signal transduction through carbohydrate-carbohydrate interaction in mouse melanoma B16 cells. J Biol Chem 1998; 273:9130-8.
    • (1998) J Biol Chem , vol.273 , pp. 9130-9138
    • Iwabuchi, K.1    Yamamura, S.2    Prinetti, A.3    Handa, K.4    Hakomori, S.5
  • 16
    • 0025945830 scopus 로고
    • Cell adhesion, spreading, and motility of GM3-expressing cells based on glycolipid-glycolipid interaction
    • Kojima N, Hakomori S. Cell adhesion, spreading, and motility of GM3-expressing cells based on glycolipid-glycolipid interaction. J Biol Chem 1991; 266:17552-8.
    • (1991) J Biol Chem , vol.266 , pp. 17552-17558
    • Kojima, N.1    Hakomori, S.2
  • 17
    • 38449097358 scopus 로고    scopus 로고
    • A cholesterol-independent membrane microdomain serves as a functional counter-receptor for E-selectin at the Colo201 cell surface and initiates signalling on E-selectin binding
    • Suzuki C, Kojima N. A cholesterol-independent membrane microdomain serves as a functional counter-receptor for E-selectin at the Colo201 cell surface and initiates signalling on E-selectin binding. J Biochem 2007; 142:55-64.
    • (2007) J Biochem , vol.142 , pp. 55-64
    • Suzuki, C.1    Kojima, N.2
  • 18
  • 19
    • 27444438906 scopus 로고    scopus 로고
    • A specific microdomain ('glycosynapse 3') controls phenotypic conversion and reversion of bladder cancer cells through GM3-mediated interaction of alpha3beta1 integrin with CD9
    • Mitsuzuka K, Handa K, Satoh M, Arai Y, Hakomori S. A specific microdomain ('glycosynapse 3') controls phenotypic conversion and reversion of bladder cancer cells through GM3-mediated interaction of alpha3beta1 integrin with CD9. J Biol Chem 2005; 280:35545-53.
    • (2005) J Biol Chem , vol.280 , pp. 35545-35553
    • Mitsuzuka, K.1    Handa, K.2    Satoh, M.3    Arai, Y.4    Hakomori, S.5
  • 20
    • 0027339266 scopus 로고
    • Regulatory role of GM3 ganglioside in alpha 5 beta 1 integrin receptor for fibronectin-mediated adhesion of FUA169 cells
    • Zheng M, Fang H, Tsuruoka T, Tsuji T, Sasaki T, Hakomori S. Regulatory role of GM3 ganglioside in alpha 5 beta 1 integrin receptor for fibronectin-mediated adhesion of FUA169 cells. J Biol Chem 1993; 268:2217-22.
    • (1993) J Biol Chem , vol.268 , pp. 2217-2222
    • Zheng, M.1    Fang, H.2    Tsuruoka, T.3    Tsuji, T.4    Sasaki, T.5    Hakomori, S.6
  • 21
    • 0028239080 scopus 로고
    • Functional role of N-glycosylation in alpha 5 beta 1 integrin receptor. De-N-glycosylation induces dissociation or altered association of alpha 5 and beta 1 subunits and concomitant loss of fibronectin binding activity
    • Zheng M, Fang H, Hakomori S. Functional role of N-glycosylation in alpha 5 beta 1 integrin receptor. De-N-glycosylation induces dissociation or altered association of alpha 5 and beta 1 subunits and concomitant loss of fibronectin binding activity. J Biol Chem 1994; 269:12325-31.
    • (1994) J Biol Chem , vol.269 , pp. 12325-12331
    • Zheng, M.1    Fang, H.2    Hakomori, S.3
  • 22
    • 0034731368 scopus 로고    scopus 로고
    • Glycosylation effect on membrane domain (GEM) involved in cell adhesion and motility: a preliminary note on functional alpha3, alpha5-CD82 glycosylation complex in ldlD 14 cells
    • Ono M, Handa K, Withers DA, Hakomori S. Glycosylation effect on membrane domain (GEM) involved in cell adhesion and motility: a preliminary note on functional alpha3, alpha5-CD82 glycosylation complex in ldlD 14 cells. Biochem Biophys Res Commun 2000; 279:744-50.
    • (2000) Biochem Biophys Res Commun , vol.279 , pp. 744-750
    • Ono, M.1    Handa, K.2    Withers, D.A.3    Hakomori, S.4
  • 23
    • 0022262016 scopus 로고
    • Aberrant glycosylation in cancer cell membranes as focused on glycolipids: overview and perspectives
    • Hakomori S. Aberrant glycosylation in cancer cell membranes as focused on glycolipids: overview and perspectives. Cancer Res 1985; 45:2405-14.
    • (1985) Cancer Res , vol.45 , pp. 2405-2414
    • Hakomori, S.1
  • 24
    • 77950410995 scopus 로고    scopus 로고
    • Alterations in glycosylation as biomarkers for cancer detection
    • Reis CA, Osorio H, Silva L, Gomes C, David L. Alterations in glycosylation as biomarkers for cancer detection. J Clin Pathol 2010; 63:322-9.
    • (2010) J Clin Pathol , vol.63 , pp. 322-329
    • Reis, C.A.1    Osorio, H.2    Silva, L.3    Gomes, C.4    David, L.5
  • 25
    • 46049114875 scopus 로고    scopus 로고
    • DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer
    • Kawamura YI, Toyota M, Kawashima R etal. DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer. Gastroenterology 2008; 135:142-51e3.
    • (2008) Gastroenterology , vol.135
    • Kawamura, Y.I.1    Toyota, M.2    Kawashima, R.3
  • 26
    • 0025778108 scopus 로고
    • Tissue distribution of 2-3 and 2-6 sialyl Lewis A antigens and significance of the ratio of two antigens for the differential diagnosis of malignant and benign disorders of the digestive tract
    • Itai S, Nishikata J, Yoneda T etal. Tissue distribution of 2-3 and 2-6 sialyl Lewis A antigens and significance of the ratio of two antigens for the differential diagnosis of malignant and benign disorders of the digestive tract. Cancer 1991; 67:1576-87.
    • (1991) Cancer , vol.67 , pp. 1576-1587
    • Itai, S.1    Nishikata, J.2    Yoneda, T.3
  • 27
    • 2542615352 scopus 로고    scopus 로고
    • Molecular mechanism for cancer-associated induction of sialyl Lewis X and sialyl Lewis A expression-the Warburg effect revisited
    • Kannagi R. Molecular mechanism for cancer-associated induction of sialyl Lewis X and sialyl Lewis A expression-the Warburg effect revisited. Glycoconj J 2004; 20:353-64.
    • (2004) Glycoconj J , vol.20 , pp. 353-364
    • Kannagi, R.1
  • 28
    • 77952272109 scopus 로고    scopus 로고
    • E-selectin and sialyl Lewis X expression is associated with lymph node metastasis of invasive micropapillary carcinoma of the breast
    • Wei J, Cui L, Liu F etal. E-selectin and sialyl Lewis X expression is associated with lymph node metastasis of invasive micropapillary carcinoma of the breast. Int J Surg Pathol 2010; 18:193-200.
    • (2010) Int J Surg Pathol , vol.18 , pp. 193-200
    • Wei, J.1    Cui, L.2    Liu, F.3
  • 29
    • 79251605755 scopus 로고    scopus 로고
    • C2-O-sLe glycoproteins are E-selectin ligands that regulate invasion of human colon and hepatic carcinoma cells
    • St Hill CA, Baharo-Hassan D, Farooqui M. C2-O-sLe glycoproteins are E-selectin ligands that regulate invasion of human colon and hepatic carcinoma cells. PLoS ONE 2011; 6:e16281.
    • (2011) PLoS ONE , vol.6
    • St Hill, C.A.1    Baharo-Hassan, D.2    Farooqui, M.3
  • 30
    • 40749118374 scopus 로고    scopus 로고
    • Current relevance of incomplete synthesis and neo-synthesis for cancer-associated alteration of carbohydrate determinants - Hakomori's concepts revisited
    • Kannagi R, Yin J, Miyazaki K, Izawa M. Current relevance of incomplete synthesis and neo-synthesis for cancer-associated alteration of carbohydrate determinants - Hakomori's concepts revisited. Biochim Biophys Acta 2008; 1780:525-31.
    • (2008) Biochim Biophys Acta , vol.1780 , pp. 525-531
    • Kannagi, R.1    Yin, J.2    Miyazaki, K.3    Izawa, M.4
  • 31
    • 2542588628 scopus 로고    scopus 로고
    • Hypoxia induces adhesion molecules on cancer cells: a missing link between Warburg effect and induction of selectin-ligand carbohydrates
    • Koike T, Kimura N, Miyazaki K etal. Hypoxia induces adhesion molecules on cancer cells: a missing link between Warburg effect and induction of selectin-ligand carbohydrates. Proc Natl Acad Sci USA 2004; 101:8132-7.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8132-8137
    • Koike, T.1    Kimura, N.2    Miyazaki, K.3
  • 32
    • 0030910277 scopus 로고    scopus 로고
    • Glucose-transporter-type-I-gene amplification correlates with sialyl-Lewis-X synthesis and proliferation in lung cancer
    • Ogawa J, Inoue H, Koide S. Glucose-transporter-type-I-gene amplification correlates with sialyl-Lewis-X synthesis and proliferation in lung cancer. Int J Cancer 1997; 74:189-92.
    • (1997) Int J Cancer , vol.74 , pp. 189-192
    • Ogawa, J.1    Inoue, H.2    Koide, S.3
  • 33
    • 46349088505 scopus 로고    scopus 로고
    • Biological function of fucosylation in cancer biology
    • Miyoshi E, Moriwaki K, Nakagawa T. Biological function of fucosylation in cancer biology. J Biochem 2008; 143:725-9.
    • (2008) J Biochem , vol.143 , pp. 725-729
    • Miyoshi, E.1    Moriwaki, K.2    Nakagawa, T.3
  • 34
    • 79959396378 scopus 로고    scopus 로고
    • Fucosylation and gastrointestinal cancer
    • Moriwaki K, Miyoshi E. Fucosylation and gastrointestinal cancer. World J Hepatol 2010; 2:151-61.
    • (2010) World J Hepatol , vol.2 , pp. 151-161
    • Moriwaki, K.1    Miyoshi, E.2
  • 36
    • 0023013620 scopus 로고
    • Monoclonal antibody 18B8, which detects synapse-associated antigens, binds to ganglioside GT3 (II3 (NeuAc)3LacCer)
    • Dubois C, Magnani JL, Grunwald GB etal. Monoclonal antibody 18B8, which detects synapse-associated antigens, binds to ganglioside GT3 (II3 (NeuAc)3LacCer). J Biol Chem 1986; 261:3826-30.
    • (1986) J Biol Chem , vol.261 , pp. 3826-3830
    • Dubois, C.1    Magnani, J.L.2    Grunwald, G.B.3
  • 37
    • 0027447521 scopus 로고
    • Ganglioside expression on human malignant melanoma assessed by quantitative immune thin-layer chromatography
    • Hamilton WB, Helling F, Lloyd KO, Livingston PO. Ganglioside expression on human malignant melanoma assessed by quantitative immune thin-layer chromatography. Int J Cancer 1993; 53:566-73.
    • (1993) Int J Cancer , vol.53 , pp. 566-573
    • Hamilton, W.B.1    Helling, F.2    Lloyd, K.O.3    Livingston, P.O.4
  • 38
    • 0022443545 scopus 로고
    • Production of oligosaccharide-binding monoclonal antibodies of diverse specificities by immunization with purified tumor-associated glycolipids inserted into liposomes with lipid A
    • Brodin T, Thurin J, Stromberg N, Karlsson KA, Sjogren HO. Production of oligosaccharide-binding monoclonal antibodies of diverse specificities by immunization with purified tumor-associated glycolipids inserted into liposomes with lipid A. Eur J Immunol 1986; 16:951-6.
    • (1986) Eur J Immunol , vol.16 , pp. 951-956
    • Brodin, T.1    Thurin, J.2    Stromberg, N.3    Karlsson, K.A.4    Sjogren, H.O.5
  • 39
    • 0030837804 scopus 로고    scopus 로고
    • Increased sialyl Lewis A expression and fucosyltransferase activity with acquisition of a high metastatic capacity in a colon cancer cell line
    • Yamada N, Chung YS, Takatsuka S etal. Increased sialyl Lewis A expression and fucosyltransferase activity with acquisition of a high metastatic capacity in a colon cancer cell line. Br J Cancer 1997; 76:582-7.
    • (1997) Br J Cancer , vol.76 , pp. 582-587
    • Yamada, N.1    Chung, Y.S.2    Takatsuka, S.3
  • 40
    • 21244447444 scopus 로고    scopus 로고
    • Expression of sialyl lewis X, sialyl Lewis A, E-cadherin and cathepsin-D in human breast cancer: immunohistochemical analysis in mammary carcinoma in situ, invasive carcinomas and their lymph node metastasis
    • Jeschke U, Mylonas I, Shabani N etal. Expression of sialyl lewis X, sialyl Lewis A, E-cadherin and cathepsin-D in human breast cancer: immunohistochemical analysis in mammary carcinoma in situ, invasive carcinomas and their lymph node metastasis. Anticancer Res 2005; 25:1615-22.
    • (2005) Anticancer Res , vol.25 , pp. 1615-1622
    • Jeschke, U.1    Mylonas, I.2    Shabani, N.3
  • 41
    • 0020259363 scopus 로고
    • Carcinoembryonic antigen (CEA) and carbohydrate determinant 19-9 (CA 19-9) localization in 121 primary and metastatic ovarian tumors: an immunohistochemical study with the use of monoclonal antibodies
    • Charpin C, Bhan AK, Zurawski VR Jr, Scully RE. Carcinoembryonic antigen (CEA) and carbohydrate determinant 19-9 (CA 19-9) localization in 121 primary and metastatic ovarian tumors: an immunohistochemical study with the use of monoclonal antibodies. Int J Gynecol Pathol 1982; 1:231-45.
    • (1982) Int J Gynecol Pathol , vol.1 , pp. 231-245
    • Charpin, C.1    Bhan, A.K.2    Zurawski Jr, V.R.3    Scully, R.E.4
  • 42
    • 0020408738 scopus 로고
    • A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II
    • Magnani JL, Nilsson B, Brockhaus M etal. A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II. J Biol Chem 1982; 257:14365-9.
    • (1982) J Biol Chem , vol.257 , pp. 14365-14369
    • Magnani, J.L.1    Nilsson, B.2    Brockhaus, M.3
  • 43
    • 0035074814 scopus 로고    scopus 로고
    • Circulating sialyl Lewis(x), sialyl Lewis(a), and sialyl Tn antigens in colorectal cancer patients: multivariate analysis of predictive factors for serum antigen levels
    • Nakagoe T, Sawai T, Tsuji T etal. Circulating sialyl Lewis(x), sialyl Lewis(a), and sialyl Tn antigens in colorectal cancer patients: multivariate analysis of predictive factors for serum antigen levels. J Gastroenterol 2001; 36:166-72.
    • (2001) J Gastroenterol , vol.36 , pp. 166-172
    • Nakagoe, T.1    Sawai, T.2    Tsuji, T.3
  • 44
    • 0023165018 scopus 로고
    • Disialoganglioside GD2 on human neuroblastoma cells: target antigen for monoclonal antibody-mediated cytolysis and suppression of tumor growth
    • Mujoo K, Cheresh DA, Yang HM, Reisfeld RA. Disialoganglioside GD2 on human neuroblastoma cells: target antigen for monoclonal antibody-mediated cytolysis and suppression of tumor growth. Cancer Res 1987; 47:1098-104.
    • (1987) Cancer Res , vol.47 , pp. 1098-1104
    • Mujoo, K.1    Cheresh, D.A.2    Yang, H.M.3    Reisfeld, R.A.4
  • 45
    • 0022559676 scopus 로고
    • Expression of GD2 ganglioside by untreated primary human neuroblastomas
    • Wu ZL, Schwartz E, Seeger R, Ladisch S. Expression of GD2 ganglioside by untreated primary human neuroblastomas. Cancer Res 1986; 46:440-3.
    • (1986) Cancer Res , vol.46 , pp. 440-443
    • Wu, Z.L.1    Schwartz, E.2    Seeger, R.3    Ladisch, S.4
  • 46
    • 0036053357 scopus 로고    scopus 로고
    • An anti-GD2 monoclonal antibody enhances apoptotic effects of anti-cancer drugs against small cell lung cancer cells via JNK (c-Jun terminal kinase) activation
    • Yoshida S, Kawaguchi H, Sato S, Ueda R, Furukawa K. An anti-GD2 monoclonal antibody enhances apoptotic effects of anti-cancer drugs against small cell lung cancer cells via JNK (c-Jun terminal kinase) activation. Jpn J Cancer Res 2002; 93:816-24.
    • (2002) Jpn J Cancer Res , vol.93 , pp. 816-824
    • Yoshida, S.1    Kawaguchi, H.2    Sato, S.3    Ueda, R.4    Furukawa, K.5
  • 47
    • 0018748995 scopus 로고
    • Lipid composition of human malignant melanoma tumors at various levels of malignant growth
    • Portoukalian J, Zwingelstein G, Dore JF. Lipid composition of human malignant melanoma tumors at various levels of malignant growth. Eur J Biochem 1979; 94:19-23.
    • (1979) Eur J Biochem , vol.94 , pp. 19-23
    • Portoukalian, J.1    Zwingelstein, G.2    Dore, J.F.3
  • 48
    • 69949083601 scopus 로고    scopus 로고
    • Shiga toxin receptor Gb3Cer/CD77: tumor-association and promising therapeutic target in pancreas and colon cancer
    • Distler U, Souady J, Hulsewig M etal. Shiga toxin receptor Gb3Cer/CD77: tumor-association and promising therapeutic target in pancreas and colon cancer. PLoS ONE 2009; 4:e6813.
    • (2009) PLoS ONE , vol.4
    • Distler, U.1    Souady, J.2    Hulsewig, M.3
  • 49
    • 0031213586 scopus 로고    scopus 로고
    • Shedding of gangliosides by human medulloblastoma cells
    • Chang F, Li R, Ladisch S. Shedding of gangliosides by human medulloblastoma cells. Exp Cell Res 1997; 234:341-6.
    • (1997) Exp Cell Res , vol.234 , pp. 341-346
    • Chang, F.1    Li, R.2    Ladisch, S.3
  • 50
    • 66149137283 scopus 로고    scopus 로고
    • GD3, an overexpressed tumor-derived ganglioside, mediates the apoptosis of activated but not resting T cells
    • Sa G, Das T, Moon C etal. GD3, an overexpressed tumor-derived ganglioside, mediates the apoptosis of activated but not resting T cells. Cancer Res 2009; 69:3095-104.
    • (2009) Cancer Res , vol.69 , pp. 3095-3104
    • Sa, G.1    Das, T.2    Moon, C.3
  • 51
    • 0026349587 scopus 로고
    • The breast tumor-associated epitope defined by monoclonal antibody 3E1·2 is an O-linked mucin carbohydrate containing N-glycolylneuraminic acid
    • Devine PL, Clark BA, Birrell GW etal. The breast tumor-associated epitope defined by monoclonal antibody 3E1·2 is an O-linked mucin carbohydrate containing N-glycolylneuraminic acid. Cancer Res 1991; 51:5826-36.
    • (1991) Cancer Res , vol.51 , pp. 5826-5836
    • Devine, P.L.1    Clark, B.A.2    Birrell, G.W.3
  • 52
    • 33645237406 scopus 로고    scopus 로고
    • Clinical evidences of GM3 (NeuGc) ganglioside expression in human breast cancer using the 14F7 monoclonal antibody labelled with (99m)Tc
    • Oliva JP, Valdes Z, Casaco A etal. Clinical evidences of GM3 (NeuGc) ganglioside expression in human breast cancer using the 14F7 monoclonal antibody labelled with (99m)Tc. Breast Cancer Res Treat 2006; 96:115-21.
    • (2006) Breast Cancer Res Treat , vol.96 , pp. 115-121
    • Oliva, J.P.1    Valdes, Z.2    Casaco, A.3
  • 53
    • 0023684038 scopus 로고
    • Detection of gangliosides as N-glycolylneuraminic acid-specific tumor-associated Hanganutziu-Deicher antigen in human retinoblastoma cells
    • Higashi H, Sasabe T, Fukui Y, Maru M, Kato S. Detection of gangliosides as N-glycolylneuraminic acid-specific tumor-associated Hanganutziu-Deicher antigen in human retinoblastoma cells. Jpn J Cancer Res 1988; 79:952-6.
    • (1988) Jpn J Cancer Res , vol.79 , pp. 952-956
    • Higashi, H.1    Sasabe, T.2    Fukui, Y.3    Maru, M.4    Kato, S.5
  • 54
    • 14244266499 scopus 로고    scopus 로고
    • Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells
    • Bardor M, Nguyen DH, Diaz S, Varki A. Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells. J Biol Chem 2005; 280:4228-37.
    • (2005) J Biol Chem , vol.280 , pp. 4228-4237
    • Bardor, M.1    Nguyen, D.H.2    Diaz, S.3    Varki, A.4
  • 55
    • 74349111138 scopus 로고    scopus 로고
    • Exogenous incorporation of neugc-rich mucin augments n-glycolyl sialic acid content and promotes malignant phenotype in mouse tumor cell lines
    • Gabri MR, Otero LL, Gomez DE, Alonso DF. Exogenous incorporation of neugc-rich mucin augments n-glycolyl sialic acid content and promotes malignant phenotype in mouse tumor cell lines. J Exp Clin Cancer Res 2009; 28:146-54.
    • (2009) J Exp Clin Cancer Res , vol.28 , pp. 146-154
    • Gabri, M.R.1    Otero, L.L.2    Gomez, D.E.3    Alonso, D.F.4
  • 56
    • 30444446808 scopus 로고    scopus 로고
    • Role of tumour-associated N-glycolylated variant of GM3 ganglioside in cancer progression: effect over CD4 expression on T cells
    • de Leon J, Fernandez A, Mesa C, Clavel M, Fernandez LE. Role of tumour-associated N-glycolylated variant of GM3 ganglioside in cancer progression: effect over CD4 expression on T cells. Cancer Immunol Immunother 2006; 55:443-50.
    • (2006) Cancer Immunol Immunother , vol.55 , pp. 443-450
    • de Leon, J.1    Fernandez, A.2    Mesa, C.3    Clavel, M.4    Fernandez, L.E.5
  • 57
    • 69949147510 scopus 로고    scopus 로고
    • Immunotherapy for cancer: synthetic carbohydrate-based vaccines
    • Buskas T, Thompson P, Boons GJ. Immunotherapy for cancer: synthetic carbohydrate-based vaccines. Chem Commun (Camb) 2009; 36:5335-49.
    • (2009) Chem Commun (Camb) , vol.36 , pp. 5335-5349
    • Buskas, T.1    Thompson, P.2    Boons, G.J.3
  • 59
    • 58149247765 scopus 로고    scopus 로고
    • The constant region of the membrane immunoglobulin mediates B cell-receptor clustering and signaling in response to membrane antigens
    • Tolar P, Hanna J, Krueger PD, Pierce SK. The constant region of the membrane immunoglobulin mediates B cell-receptor clustering and signaling in response to membrane antigens. Immunity 2009; 30:44-55.
    • (2009) Immunity , vol.30 , pp. 44-55
    • Tolar, P.1    Hanna, J.2    Krueger, P.D.3    Pierce, S.K.4
  • 61
    • 10744226998 scopus 로고    scopus 로고
    • Consistent antibody response against ganglioside GD2 induced in patients with melanoma by a GD2 lactone-keyhole limpet hemocyanin conjugate vaccine plus immunological adjuvant QS-21
    • Ragupathi G, Livingston PO, Hood C etal. Consistent antibody response against ganglioside GD2 induced in patients with melanoma by a GD2 lactone-keyhole limpet hemocyanin conjugate vaccine plus immunological adjuvant QS-21. Clin Cancer Res 2003; 9:5214-20.
    • (2003) Clin Cancer Res , vol.9 , pp. 5214-5220
    • Ragupathi, G.1    Livingston, P.O.2    Hood, C.3
  • 62
    • 4644245711 scopus 로고    scopus 로고
    • Vaccination of patients with small-cell lung cancer with synthetic fucosyl GM-1 conjugated to keyhole limpet hemocyanin
    • Krug LM, Ragupathi G, Hood C etal. Vaccination of patients with small-cell lung cancer with synthetic fucosyl GM-1 conjugated to keyhole limpet hemocyanin. Clin Cancer Res 2004; 10:6094-100.
    • (2004) Clin Cancer Res , vol.10 , pp. 6094-6100
    • Krug, L.M.1    Ragupathi, G.2    Hood, C.3
  • 63
    • 0028989972 scopus 로고
    • Approaches to augmenting the immunogenicity of melanoma gangliosides: from whole melanoma cells to ganglioside-KLH conjugate vaccines
    • Livingston PO. Approaches to augmenting the immunogenicity of melanoma gangliosides: from whole melanoma cells to ganglioside-KLH conjugate vaccines. Immunol Rev 1995; 145:147-66.
    • (1995) Immunol Rev , vol.145 , pp. 147-166
    • Livingston, P.O.1
  • 64
    • 0028205790 scopus 로고
    • Improved survival in stage III melanoma patients with GM2 antibodies: a randomized trial of adjuvant vaccination with GM2 ganglioside
    • Livingston PO, Wong GY, Adluri S etal. Improved survival in stage III melanoma patients with GM2 antibodies: a randomized trial of adjuvant vaccination with GM2 ganglioside. J Clin Oncol 1994; 12:1036-44.
    • (1994) J Clin Oncol , vol.12 , pp. 1036-1044
    • Livingston, P.O.1    Wong, G.Y.2    Adluri, S.3
  • 65
    • 0028914976 scopus 로고
    • Serological response patterns of melanoma patients immunized with a GM2 ganglioside conjugate vaccine
    • Kitamura K, Livingston PO, Fortunato SR etal. Serological response patterns of melanoma patients immunized with a GM2 ganglioside conjugate vaccine. Proc Natl Acad Sci USA 1995; 92:2805-9.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2805-2809
    • Kitamura, K.1    Livingston, P.O.2    Fortunato, S.R.3
  • 66
    • 0028981087 scopus 로고
    • GM2-KLH conjugate vaccine: increased immunogenicity in melanoma patients after administration with immunological adjuvant QS-21
    • Helling F, Zhang S, Shang A etal. GM2-KLH conjugate vaccine: increased immunogenicity in melanoma patients after administration with immunological adjuvant QS-21. Cancer Res 1995; 55:2783-8.
    • (1995) Cancer Res , vol.55 , pp. 2783-2788
    • Helling, F.1    Zhang, S.2    Shang, A.3
  • 68
    • 78449263060 scopus 로고    scopus 로고
    • EOTRC Melanoma Group, randomized phase III trial comparing postoperative adjuvant ganglioside GM2-KLH/QS-21 vaccination versus observation in stage II (T3-T4N0M0) melanoma: final results of study EORTC 18961
    • Eggermont AM, Suciu S, Rutkowski PM etal. EOTRC Melanoma Group, randomized phase III trial comparing postoperative adjuvant ganglioside GM2-KLH/QS-21 vaccination versus observation in stage II (T3-T4N0M0) melanoma: final results of study EORTC 18961. J Clin Oncol 2010; 28:2012-18.
    • (2010) J Clin Oncol , vol.28 , pp. 2012-2018
    • Eggermont, A.M.1    Suciu, S.2    Rutkowski, P.M.3
  • 69
    • 3242695961 scopus 로고    scopus 로고
    • Sequential immunization of melanoma patients with GD3 ganglioside vaccine and anti-idiotypic monoclonal antibody that mimics GD3 ganglioside
    • Chapman PB, Wu D, Ragupathi G etal. Sequential immunization of melanoma patients with GD3 ganglioside vaccine and anti-idiotypic monoclonal antibody that mimics GD3 ganglioside. Clin Cancer Res 2004; 10:4717-23.
    • (2004) Clin Cancer Res , vol.10 , pp. 4717-4723
    • Chapman, P.B.1    Wu, D.2    Ragupathi, G.3
  • 70
    • 27244446896 scopus 로고    scopus 로고
    • Phase III study of adjuvant vaccination with Bec2/bacille Calmette-Guérin in responding patients with limited-disease small-cell lung cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study)
    • Giaccone G, Debruyne C, Felip E etal. Phase III study of adjuvant vaccination with Bec2/bacille Calmette-Guérin in responding patients with limited-disease small-cell lung cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study). J Clin Oncol 2005; 23:6854-64.
    • (2005) J Clin Oncol , vol.23 , pp. 6854-6864
    • Giaccone, G.1    Debruyne, C.2    Felip, E.3
  • 71
    • 79953180541 scopus 로고    scopus 로고
    • Anti-NeuGcGM3 antibodies, actively elicited by idiotypic vaccination in nonsmall cell lung cancer patients, induce tumor cell death by an oncosis-like mechanism
    • Hernandez AM, Rodriguez N, Gonzalez JE etal. Anti-NeuGcGM3 antibodies, actively elicited by idiotypic vaccination in nonsmall cell lung cancer patients, induce tumor cell death by an oncosis-like mechanism. J Immunol 2011; 186:3735-44.
    • (2011) J Immunol , vol.186 , pp. 3735-3744
    • Hernandez, A.M.1    Rodriguez, N.2    Gonzalez, J.E.3
  • 72
    • 78650730811 scopus 로고    scopus 로고
    • NGcGM3 ganglioside: a privileged target for cancer vaccines
    • Fernandez LE, Gabri MR, Guthmann MD etal. NGcGM3 ganglioside: a privileged target for cancer vaccines. Clin Dev Immunol 2010; 2010:814397-405.
    • (2010) Clin Dev Immunol , vol.2010 , pp. 814397-814405
    • Fernandez, L.E.1    Gabri, M.R.2    Guthmann, M.D.3
  • 73
    • 77950690146 scopus 로고    scopus 로고
    • Combined therapeutic effect of a monoclonal anti-idiotype tumor vaccine against NeuGc-containing gangliosides with chemotherapy in a breast carcinoma model
    • Fuentes D, Avellanet J, Garcia A etal. Combined therapeutic effect of a monoclonal anti-idiotype tumor vaccine against NeuGc-containing gangliosides with chemotherapy in a breast carcinoma model. Breast Cancer Res Treat 2010; 120:379-89.
    • (2010) Breast Cancer Res Treat , vol.120 , pp. 379-389
    • Fuentes, D.1    Avellanet, J.2    Garcia, A.3
  • 74
    • 42549128373 scopus 로고    scopus 로고
    • 1E10 anti-idiotype vaccine in non-small cell lung cancer: experience in stage IIIb/IV patients
    • Alfonso S, Diaz RM, de la Torre A etal. 1E10 anti-idiotype vaccine in non-small cell lung cancer: experience in stage IIIb/IV patients. Cancer Biol Ther 2007; 6:1847-52.
    • (2007) Cancer Biol Ther , vol.6 , pp. 1847-1852
    • Alfonso, S.1    Diaz, R.M.2    de la Torre, A.3
  • 75
    • 33646768654 scopus 로고    scopus 로고
    • Cellular and humoral immune response to N-Glycolyl-GM3 elicited by prolonged immunotherapy with an anti-idiotypic vaccine in high-risk and metastatic breast cancer patients
    • Guthmann MD, Castro MA, Cinat G etal. Cellular and humoral immune response to N-Glycolyl-GM3 elicited by prolonged immunotherapy with an anti-idiotypic vaccine in high-risk and metastatic breast cancer patients. J Immunother 2006; 29:215-23.
    • (2006) J Immunother , vol.29 , pp. 215-223
    • Guthmann, M.D.1    Castro, M.A.2    Cinat, G.3
  • 76
    • 58149456558 scopus 로고    scopus 로고
    • Characterization of the antibody response against NeuGcGM3 ganglioside elicited in non-small cell lung cancer patients immunized with an anti-idiotype antibody
    • Hernandez AM, Toledo D, Martinez D etal. Characterization of the antibody response against NeuGcGM3 ganglioside elicited in non-small cell lung cancer patients immunized with an anti-idiotype antibody. J Immunol 2008; 181:6625-34.
    • (2008) J Immunol , vol.181 , pp. 6625-6634
    • Hernandez, A.M.1    Toledo, D.2    Martinez, D.3
  • 77
    • 45349091152 scopus 로고    scopus 로고
    • Heterophilic NeuGcGM3 ganglioside cancer vaccine in advanced melanoma patients: results of a Phase Ib/IIa study
    • Osorio M, Gracia E, Rodriguez E etal. Heterophilic NeuGcGM3 ganglioside cancer vaccine in advanced melanoma patients: results of a Phase Ib/IIa study. Cancer Biol Ther 2008; 7:488-95.
    • (2008) Cancer Biol Ther , vol.7 , pp. 488-495
    • Osorio, M.1    Gracia, E.2    Rodriguez, E.3
  • 78
    • 0024380793 scopus 로고
    • Antibody response after immunization with the gangliosides GM1, GM2, GM3, GD2 and GD3 in the mouse
    • Livingston PO, Ritter G, Calves MJ. Antibody response after immunization with the gangliosides GM1, GM2, GM3, GD2 and GD3 in the mouse. Cancer Immunol Immunother 1989; 29:179-84.
    • (1989) Cancer Immunol Immunother , vol.29 , pp. 179-184
    • Livingston, P.O.1    Ritter, G.2    Calves, M.J.3
  • 79
    • 0033588519 scopus 로고    scopus 로고
    • Enhancement of the immune response to poorly immunogenic gangliosides after incorporation into very small size proteoliposomes (VSSP)
    • Estevez F, Carr A, Solorzano L etal. Enhancement of the immune response to poorly immunogenic gangliosides after incorporation into very small size proteoliposomes (VSSP). Vaccine 1999; 18:190-7.
    • (1999) Vaccine , vol.18 , pp. 190-197
    • Estevez, F.1    Carr, A.2    Solorzano, L.3
  • 80
    • 7444262837 scopus 로고    scopus 로고
    • Active specific immunotherapy of melanoma with a GM3 ganglioside-based vaccine: a report on safety and immunogenicity
    • Guthmann MD, Bitton RJ, Carnero AJ etal. Active specific immunotherapy of melanoma with a GM3 ganglioside-based vaccine: a report on safety and immunogenicity. J Immunother 2004; 27:442-51.
    • (2004) J Immunother , vol.27 , pp. 442-451
    • Guthmann, M.D.1    Bitton, R.J.2    Carnero, A.J.3
  • 81
    • 67649647747 scopus 로고    scopus 로고
    • Synthesis of sialyl Lewis(a) (sLe (a), CA19-9) and construction of an immunogenic sLe(a) vaccine
    • Ragupathi G, Damani P, Srivastava G etal. Synthesis of sialyl Lewis(a) (sLe (a), CA19-9) and construction of an immunogenic sLe(a) vaccine. Cancer Immunol Immunother 2009; 58:1397-405.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 1397-1405
    • Ragupathi, G.1    Damani, P.2    Srivastava, G.3
  • 82
    • 0004825568 scopus 로고    scopus 로고
    • Immunization of ovarian cancer patients with a synthetic Lewis(y)-protein conjugate vaccine: a phase 1 trial
    • Sabbatini PJ, Kudryashov V, Ragupathi G etal. Immunization of ovarian cancer patients with a synthetic Lewis(y)-protein conjugate vaccine: a phase 1 trial. Int J Cancer 2000; 87:79-85.
    • (2000) Int J Cancer , vol.87 , pp. 79-85
    • Sabbatini, P.J.1    Kudryashov, V.2    Ragupathi, G.3
  • 83
    • 67649782034 scopus 로고    scopus 로고
    • Determination of cellular lipids bound to human CD1d molecules
    • Cox D, Fox L, Tian R etal. Determination of cellular lipids bound to human CD1d molecules. PLoS ONE 2009; 4:e5325.
    • (2009) PLoS ONE , vol.4
    • Cox, D.1    Fox, L.2    Tian, R.3
  • 84
    • 0035576187 scopus 로고    scopus 로고
    • Human B cell activation by autologous NK cells is regulated by CD40-CD40 ligand interaction: role of memory B cells and CD5+ B cells
    • Blanca IR, Bere EW, Young HA, Ortaldo JR. Human B cell activation by autologous NK cells is regulated by CD40-CD40 ligand interaction: role of memory B cells and CD5+ B cells. J Immunol 2001; 167:6132-9.
    • (2001) J Immunol , vol.167 , pp. 6132-6139
    • Blanca, I.R.1    Bere, E.W.2    Young, H.A.3    Ortaldo, J.R.4
  • 85
    • 46149103655 scopus 로고    scopus 로고
    • NK T cells provide lipid antigen-specific cognate help for B cells
    • Leadbetter EA, Brigl M, Illarionov P etal. NK T cells provide lipid antigen-specific cognate help for B cells. Proc Natl Acad Sci USA 2008; 105:8339-44.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 8339-8344
    • Leadbetter, E.A.1    Brigl, M.2    Illarionov, P.3
  • 86
    • 0031938031 scopus 로고    scopus 로고
    • Enhancement of T cell-independent immune responses in vivo by CD40 antibodies
    • Dullforce P, Sutton DC, Heath AW. Enhancement of T cell-independent immune responses in vivo by CD40 antibodies. Nat Med 1998; 4:88-91.
    • (1998) Nat Med , vol.4 , pp. 88-91
    • Dullforce, P.1    Sutton, D.C.2    Heath, A.W.3
  • 88
    • 0032975042 scopus 로고    scopus 로고
    • Randomized phase II study of BR96-doxorubicin conjugate in patients with metastatic breast cancer
    • Tolcher A, Sugarman S, Gelmon K etal. Randomized phase II study of BR96-doxorubicin conjugate in patients with metastatic breast cancer. J Clin Oncol 1999; 17:478-84.
    • (1999) J Clin Oncol , vol.17 , pp. 478-484
    • Tolcher, A.1    Sugarman, S.2    Gelmon, K.3
  • 89
    • 0029925934 scopus 로고    scopus 로고
    • Treatment of advanced solid tumors with immunotoxin LMB-1: an antibody linked to Pseudomonas exotoxin
    • Pai LH, Wittes R, Setser A, Willingham MC, Pastan I. Treatment of advanced solid tumors with immunotoxin LMB-1: an antibody linked to Pseudomonas exotoxin. Nat Med 1996; 2:350-3.
    • (1996) Nat Med , vol.2 , pp. 350-353
    • Pai, L.H.1    Wittes, R.2    Setser, A.3    Willingham, M.C.4    Pastan, I.5
  • 90
    • 34547759863 scopus 로고    scopus 로고
    • High-throughput carbohydrate microarray profiling of 27 antibodies demonstrates widespread specificity problems
    • Manimala JC, Roach TA, Li Z, Gildersleeve JC. High-throughput carbohydrate microarray profiling of 27 antibodies demonstrates widespread specificity problems. Glycobiology 2007; 17:17C-23C.
    • (2007) Glycobiology , vol.17
    • Manimala, J.C.1    Roach, T.A.2    Li, Z.3    Gildersleeve, J.C.4
  • 91
    • 33745238056 scopus 로고    scopus 로고
    • A new anticancer glycolipid monoclonal antibody, SC104, which directly induces tumor cell apoptosis
    • Durrant LG, Harding SJ, Green NH, Buckberry LD, Parsons T. A new anticancer glycolipid monoclonal antibody, SC104, which directly induces tumor cell apoptosis. Cancer Res 2006; 66:5901-9.
    • (2006) Cancer Res , vol.66 , pp. 5901-5909
    • Durrant, L.G.1    Harding, S.J.2    Green, N.H.3    Buckberry, L.D.4    Parsons, T.5
  • 92
    • 79952254471 scopus 로고    scopus 로고
    • Human monoclonal antibodies to sialyl-Lewisa (CA19·9) with potent CDC, ADCC, and antitumor activity
    • Sawada R, Sun SM, Wu X etal. Human monoclonal antibodies to sialyl-Lewisa (CA19·9) with potent CDC, ADCC, and antitumor activity. Clin Cancer Res 2011; 17:1024-32.
    • (2011) Clin Cancer Res , vol.17 , pp. 1024-1032
    • Sawada, R.1    Sun, S.M.2    Wu, X.3
  • 93
    • 0026059644 scopus 로고
    • Effect of a chimeric anti-ganglioside GD2 antibody on cell-mediated lysis of human neuroblastoma cells
    • Barker E, Mueller BM, Handgretinger R, Herter M, Yu AL, Reisfeld RA. Effect of a chimeric anti-ganglioside GD2 antibody on cell-mediated lysis of human neuroblastoma cells. Cancer Res 1991; 51:144-9.
    • (1991) Cancer Res , vol.51 , pp. 144-149
    • Barker, E.1    Mueller, B.M.2    Handgretinger, R.3    Herter, M.4    Yu, A.L.5    Reisfeld, R.A.6
  • 94
    • 0030929898 scopus 로고    scopus 로고
    • A phase I/IB trial of murine monoclonal anti-GD2 antibody 14.G2a plus interleukin-2 in children with refractory neuroblastoma: a report of the Children's Cancer Group
    • Frost JD, Hank JA, Reaman GH etal. A phase I/IB trial of murine monoclonal anti-GD2 antibody 14.G2a plus interleukin-2 in children with refractory neuroblastoma: a report of the Children's Cancer Group. Cancer 1997; 80:317-33.
    • (1997) Cancer , vol.80 , pp. 317-333
    • Frost, J.D.1    Hank, J.A.2    Reaman, G.H.3
  • 95
    • 36849018928 scopus 로고    scopus 로고
    • Phase I study of targeted radioimmunotherapy for leptomeningeal cancers using intra-Ommaya 131-I-3F8
    • Kramer K, Humm JL, Souweidane MM etal. Phase I study of targeted radioimmunotherapy for leptomeningeal cancers using intra-Ommaya 131-I-3F8. J Clin Oncol 2007; 25:5465-70.
    • (2007) J Clin Oncol , vol.25 , pp. 5465-5470
    • Kramer, K.1    Humm, J.L.2    Souweidane, M.M.3
  • 96
    • 0034913511 scopus 로고    scopus 로고
    • Construction of humanized anti-ganglioside monoclonal antibodies with potent immune effector functions
    • Nakamura K, Tanaka Y, Shitara K, Hanai N. Construction of humanized anti-ganglioside monoclonal antibodies with potent immune effector functions. Cancer Immunol Immunother 2001; 50:275-84.
    • (2001) Cancer Immunol Immunother , vol.50 , pp. 275-284
    • Nakamura, K.1    Tanaka, Y.2    Shitara, K.3    Hanai, N.4
  • 98
    • 84952976235 scopus 로고    scopus 로고
    • Anti-GD2 Strategy in the Treatment of Neuroblastoma
    • Yang RK, Sondel PM. Anti-GD2 Strategy in the Treatment of Neuroblastoma. Drugs Future 2010; 35:665-80.
    • (2010) Drugs Future , vol.35 , pp. 665-680
    • Yang, R.K.1    Sondel, P.M.2
  • 99
    • 33947223233 scopus 로고    scopus 로고
    • Disialoganglioside directed immunotherapy of neuroblastoma
    • Modak S, Cheung NK. Disialoganglioside directed immunotherapy of neuroblastoma. Cancer Invest 2007; 25:67-77.
    • (2007) Cancer Invest , vol.25 , pp. 67-77
    • Modak, S.1    Cheung, N.K.2
  • 100
    • 0343208997 scopus 로고
    • Disialoganglioside GD3 on human melanoma serves as a relevant target antigen for monoclonal antibody-mediated tumor cytolysis
    • Cheresh DA, Honsik CJ, Staffileno LK, Jung G, Reisfeld RA. Disialoganglioside GD3 on human melanoma serves as a relevant target antigen for monoclonal antibody-mediated tumor cytolysis. Proc Natl Acad Sci USA 1985; 82:5155-9.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 5155-5159
    • Cheresh, D.A.1    Honsik, C.J.2    Staffileno, L.K.3    Jung, G.4    Reisfeld, R.A.5
  • 101
    • 0025299904 scopus 로고
    • Homophilic binding of mouse monoclonal antibodies against GD3 ganglioside
    • Chapman PB, Yuasa H, Houghton AN. Homophilic binding of mouse monoclonal antibodies against GD3 ganglioside. J Immunol 1990; 145:891-8.
    • (1990) J Immunol , vol.145 , pp. 891-898
    • Chapman, P.B.1    Yuasa, H.2    Houghton, A.N.3
  • 102
    • 0034659952 scopus 로고    scopus 로고
    • Analysis of therapeutic and immunologic effects of R(24) anti-GD3 monoclonal antibody in 37 patients with metastatic melanoma
    • Kirkwood JM, Mascari RA, Edington HD etal. Analysis of therapeutic and immunologic effects of R(24) anti-GD3 monoclonal antibody in 37 patients with metastatic melanoma. Cancer 2000; 88:2693-702.
    • (2000) Cancer , vol.88 , pp. 2693-2702
    • Kirkwood, J.M.1    Mascari, R.A.2    Edington, H.D.3
  • 103
    • 0033605251 scopus 로고    scopus 로고
    • The role of homophilic binding in anti-tumor antibody R24 recognition of molecular surfaces. Demonstration of an intermolecular beta-sheet interaction between vh domains
    • Kaminski MJ, MacKenzie CR, Mooibroek MJ etal. The role of homophilic binding in anti-tumor antibody R24 recognition of molecular surfaces. Demonstration of an intermolecular beta-sheet interaction between vh domains. J Biol Chem 1999; 274:5597-604.
    • (1999) J Biol Chem , vol.274 , pp. 5597-5604
    • Kaminski, M.J.1    MacKenzie, C.R.2    Mooibroek, M.J.3
  • 104
    • 0033179392 scopus 로고    scopus 로고
    • A monoclonal antibody reactive with a 40-kDa molecule on fetal thymocytes and tumor cells blocks proliferation and stimulates aggregation and apoptosis
    • Fernandes DM, Baird AM, Berg LJ, Rock KL. A monoclonal antibody reactive with a 40-kDa molecule on fetal thymocytes and tumor cells blocks proliferation and stimulates aggregation and apoptosis. J Immunol 1999; 163:1306-14.
    • (1999) J Immunol , vol.163 , pp. 1306-1314
    • Fernandes, D.M.1    Baird, A.M.2    Berg, L.J.3    Rock, K.L.4
  • 105
    • 22244491314 scopus 로고    scopus 로고
    • Characterization of a proapoptotic antiganglioside GM2 monoclonal antibody and evaluation of its therapeutic effect on melanoma and small cell lung carcinoma xenografts
    • Retter MW, Johnson JC, Peckham DW etal. Characterization of a proapoptotic antiganglioside GM2 monoclonal antibody and evaluation of its therapeutic effect on melanoma and small cell lung carcinoma xenografts. Cancer Res 2005; 65:6425-34.
    • (2005) Cancer Res , vol.65 , pp. 6425-6434
    • Retter, M.W.1    Johnson, J.C.2    Peckham, D.W.3
  • 106
    • 0033624355 scopus 로고    scopus 로고
    • A mouse IgG1 monoclonal antibody specific for N-glycolyl GM3 ganglioside recognized breast and melanoma tumors
    • Carr A, Mullet A, Mazorra Z etal. A mouse IgG1 monoclonal antibody specific for N-glycolyl GM3 ganglioside recognized breast and melanoma tumors. Hybridoma 2000; 19:241-7.
    • (2000) Hybridoma , vol.19 , pp. 241-247
    • Carr, A.1    Mullet, A.2    Mazorra, Z.3
  • 108
    • 69749108893 scopus 로고    scopus 로고
    • The RAV12 monoclonal antibody recognizes the N-linked glycotope RAAG12: expression in human normal and tumor tissues
    • Coberly SK, Chen FZ, Armanini MP etal. The RAV12 monoclonal antibody recognizes the N-linked glycotope RAAG12: expression in human normal and tumor tissues. Arch Pathol Lab Med 2009; 133:1403-12.
    • (2009) Arch Pathol Lab Med , vol.133 , pp. 1403-1412
    • Coberly, S.K.1    Chen, F.Z.2    Armanini, M.P.3
  • 109
    • 34548792419 scopus 로고    scopus 로고
    • RAV12 accelerates the desensitization of Akt/PKB pathway of insulin-like growth factor I receptor signaling in COLO205
    • Li JC, Li R. RAV12 accelerates the desensitization of Akt/PKB pathway of insulin-like growth factor I receptor signaling in COLO205. Cancer Res 2007; 67:8856-64.
    • (2007) Cancer Res , vol.67 , pp. 8856-8864
    • Li, J.C.1    Li, R.2
  • 110
    • 77649093935 scopus 로고    scopus 로고
    • Phase 1 experience with an anti-glycotope monoclonal antibody, RAV12, in recurrent adenocarcinoma
    • Burris HA III, Rosen LS, Rocha-Lima CM etal. Phase 1 experience with an anti-glycotope monoclonal antibody, RAV12, in recurrent adenocarcinoma. Clin Cancer Res 2010; 16:1673-81.
    • (2010) Clin Cancer Res , vol.16 , pp. 1673-1681
    • Burris III, H.A.1    Rosen, L.S.2    Rocha-Lima, C.M.3
  • 111
    • 52549096811 scopus 로고    scopus 로고
    • Immunization with GM3 ganglioside nanoparticulated vaccine confers an effector CD8+ T cells-mediated protection against melanoma B16 challenge
    • Mazorra Z, Mesa C, Fernandez A, Fernandez L. Immunization with GM3 ganglioside nanoparticulated vaccine confers an effector CD8+ T cells-mediated protection against melanoma B16 challenge. Cancer Immunol Immunother 2008; 57:1771-80.
    • (2008) Cancer Immunol Immunother , vol.57 , pp. 1771-1780
    • Mazorra, Z.1    Mesa, C.2    Fernandez, A.3    Fernandez, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.