Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts

Cancer Research

Volumn 69, Issue 17, 2009, Pages 6915-6923

  Kapitonov, Dmitri ^a   Allegood, Jeremy C ^a   Mitchell, Clint ^a   Hait, Nitai C ^a   Almenara, Jorge A ^b   Adams, Jeffrey K ^c   Zipkin, Robert E ^c   Dent, Paul ^a   Kordula, Tomasz ^a   Milstien, Sheldon ^a   Spiegel, Sarah ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c Enzo Life Sciences International Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 1 INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER INVASION; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; GLIOBLASTOMA; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; UPREGULATION;

AMINO ALCOHOLS; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM NEOPLASMS; ENZYME INHIBITORS; FEMALE; GLIOBLASTOMA; HUMANS; ISOENZYMES; MALE; MICE; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 70149120314     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-0664     Document Type: Article

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