In vitro and in vivo induction of apoptosis by sphingosine and N,N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells

Clinical Cancer Research

Volumn 3, Issue 2, 1997, Pages 257-264

  Shirahama, Tsutomu ^a,b,c   Sweeney, Elizabeth A ^a,b,e   Sakakura, Chouhei ^a,b   Singhal, Anil K ^a,b   Nishiyama, Kenryu ^d   Akiyama, Shin Ichi ^d   Hakomori, Sen Itiroh ^a,b   Igarashi, Yasuyuki ^a,b,e  

^a The Biomembrane Institute   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c KAGOSHIMA UNIVERSITY   (Japan)

^d KAGOSHIMA UNIVERSITY   (Japan)

^e USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; DOXORUBICIN; GLYCOPROTEIN P; N,N DIMETHYLSPHINGOSINE; SPHINGOSINE; STAUROSPORINE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOLOGICAL TRANSPORT; CARBON RADIOISOTOPES; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; DNA FRAGMENTATION; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; FEMALE; FLOW CYTOMETRY; HUMANS; KB CELLS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; P-GLYCOPROTEIN; SPHINGOSINE; TRITIUM; TUMOR CELLS, CULTURED;

EID: 0031035476     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Hannun, Y. A., and Bell, R. M. Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science (Washington DC), 243: 500-507, 1989.
2. Merrill, A. H., and Stevens, V. Modulation of protein kinase C and diverse cell functions by sphingosine - a pharmacologically interesting compound linking sphingolipids and signal transduction. Biochim. Biophys. Acta, 1010: 131-139, 1989.
3. Hakomori, S. Bifunctional role of glycosphingolipids: modulators for transmembrane signaling and mediators for cellular interactions. J. Biol. Chem., 265: 18713-18716, 1990.
4. Hannun, Y. A., and Linardic, C. M. Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. Biochim. Biophys. Acta, 1154: 223-236, 1993.
5. Ohta, H., Sweeney, E. A., Masamune, A., Yatomi, Y., Hakomori, S., and Igarashi, Y. Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation. Cancer Res., 55: 691-697, 1995.
6. Ohta, H., Ruan, F., Hakomori, S., and Igarashi, Y. Quantification of free sphingosine in cultured cells by acylation with radioactive acetic anhydride. Anal. Biochem., 222: 489-494, 1994.
7. Ohta, H., Yatomi, Y., Sweeney, E. A., Hakomori, S., and Igarashi, Y. A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-α in human neutrophils. FEBS Lett., 355: 267-270, 1994.
8. Sweeney, E. A., Sakakura, C., Shirahama, T., Masamune, A., Ohta, H., Hakomori, S., and Igarashi, Y. Sphingosine and N,N-dimethylsphingosine induce apoptosis in a variety of human cancer cell lines. Int. J. Cancer, 66: 358-366, 1996.
9. Endo, K., Igarashi, Y., Nisar, M., Zhou, Q., and Hakomori, S. Cell membrane signalling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice. Cancer Res., 51: 1613-1618, 1991.
10. Thompson, C. B. Apoptosis in the pathogenesis and treatment of disease. Science (Washington DC), 267: 1456-1462, 1995.
11. Fisher, E. D. Apoptosis in cancer therapy: crossing the threshold. Cell, 78: 539-542, 1994.
12. Ling, Y-H., Priebe, W., and Perez-Soler, R. Apoptosis induced by anthracycline antibiotics in P388 parent and MDR cells. Cancer Res., 53: 1845-1852, 1993.
13. Gottesman, M. M., and Pastan, I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem., 62: 385-427, 1993.
14. Nishiyama, K., Shirahama, T., Yoshimura, A., Sumizawa, T., Furukawa, T., Ichikawa-Haraguchi, M., Akiyama, S., and Ohi, Y. Expression of the multidrug transporter, P-glycoprotein, in renal and transitional cell carcinomas. Cancer (Phila.), 71: 3612-3619, 1993.
15. Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M. M., Pastan, I., and Willingham, M. C. Cellular localization of the multidrug resistance gene product P-glycoprotein in normal human tissues. Proc. Natl. Acad. Sci. USA, 84: 7735-7738, 1987.
16. Igarashi, Y., Hakomori, S., Toyokuni, T., Dean, B., Fujita, S., Sugimoto, M., Ogawa, T., El-Ghendy, K., and Racker, E. Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities. Biochemistry, 28: 6796-6800, 1989.
17. Ruan, F., Sadahira, Y., Hakomori, S., and Igarashi, Y. Chemical synthesis of D-erythro-sphingosine-1-phosphate, and its inhibitory effect on cell motility. Bioorg. Med. Chem. Lett., 2: 973-978, 1992.
18. Akiyama, S., Fojo, A., Hanover, J. A., Pastan, I., and Gottesman, M. Isolation and genetic characterization of human KB cell lines resistant to multiple drugs. Somatic Cell Genet., 11: 117-126, 1985.
19. Niwa, K., Yamada, K., Furukawa, T., Shudo, N., Seto, K., Matsumoto, T., Takao, S., Akiyama, S., and Shimazu, H. Effect of a dihydropyridine analogue, 2-[benzyl(phenyl)amino]ethyl 1,4-dihydro-2,6-dimethyl-5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)- 1(2-morpholino-ethyl)-4-(3-nitrophenyl)-3-pyridinecarboxylate on reversing in vivo resistance of tumor cells to Adriamycin. Cancer Res., 52: 3655-3660, 1992.
20. Wang, E. Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl-2 is involved. Cancer Res., 55: 2284-2292, 1995.
21. Bligh, E. G., and Dyer, W. J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol., 37: 911-917, 1959.
22. Carmichael, J., Degraff, W. G., Gazdar, A. F., Minna, J. D., and Mitchell, J. B. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res., 47: 936-942, 1987.
23. Park, Y. S., Hakomori, S., Kawa, S., Ruan, F., and Igarashi, Y. Liposomal N,N,N-trimethylsphingosine (TMS) as an inhibitor of B16 melanoma cell growth and metastasis with reduced toxicity and enhanced drug efficacy compared to free TMS: cell membrane signalling as a target in cancer therapy. Cancer Res., 54: 2213-2217, 1994.
24. Gavrieli, Y., Sherman, Y., and Ben-Sasson, S. A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol., 119: 493-501, 1992.
25. Sadahira, Y., Ruan, F., Hakomori, S., and Igarashi, Y. Sphingosine-1-phosphate, a specific endogenous signalling molecule controlling cell motility and tumor cell invasiveness. Proc. Natl. Acad. Sci. USA, 89: 9686-9690, 1992.
26. Schwartz, G. K., Jiang, J., Kelsen, D. P., and Albino, A. P. Protein kinase C: a novel target for inhibiting gastric cancer cell invasion. J. Natl. Cancer Inst., 85: 402-407, 1993.
27. Schwartz, G. K., Haimovitz-Friedman, A., Dhupar, S. K., Ehleiter, D., Maslak, P., Lai, L., Loganzo, F., Kelsen, D. P., Fuks, Z., and Albino, A. P. Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells. J. Natl. Cancer Inst., 87: 1394-1398, 1995.
28. Hannun, Y. A. The sphingomyelin cycle and the second messenger function of ceramide. J. Biol. Chem., 209: 3125-3128, 1994.
29. Dressler, K. A., Mathias, S., and Kolesnick, R. N. Tumor necrosis factor-α activates the sphingomyelin signal transduction pathway in a cell-free system. Science (Washington DC), 255: 1715-1718, 1992.
30. Pushkareva, M. Y., Khan, W. A., Alessenko, A. V., Sahyoun, N., and Hannun, Y. A. Sphingosine activation of protein kinases in Jurkat T cells. J. Biol. Chem., 267: 15246-15251, 1992.
31. Megidish, T., White, T., Takio, K., Titani, K., Igarashi, Y., and Hakomori, S. The signal modulator protein 14-3-3 is a target of sphingosine or N, N-dimethylsphingosine-dependent kinase in 3T3(A31) cells. Biochem. Biophys. Res. Commun., 216: 739-747, 1995.
32. Pushkareva, M., Chao, R., Bielawska, A., Merrill, A. H., Jr., Crane, H. M., Lagu, B., Liotta, D., and Hannun, Y. A. Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine. Biochemistry, 34: 1885-1892, 1995.
33. Sakakura, C., Sweeney, E. A., Shirahama, T., Hakomori, S., and Igarashi, Y. Suppression of Bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation. FEBS Lett., 379: 177-180, 1996.
34. Sato, W., Yusa, K., Naito, M., and Tsuruo, T. Staurosporine, a potent inhibitor of C-kinase, enhances drug accumulation in multidrug-resistant cells. Biochem. Biophys. Res. Commun., 173: 1252-1257, 1990.
35. Fine, R. L., Patel, J., and Chabner, B. A. Phorbol esters induce multidrug resistance in human breast cancer cells. Proc. Natl. Acad. Sci. USA, 55: 582-586, 1988.
36. Chambers, T. C., McAvoy, E. M., Jacobs, J. W., and Eilon, G. Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells. J. Biol. Chem., 265: 7679-7686, 1990.
37. Sachs, C. W., Safa, A. R., Harrison, S. D., and Fine, R. L. Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C. J. Biol. Chem., 270: 26639-26648, 1995.
38. Bose, R., Verheil, M., Haimovitz-Friedman, A., Scotto, K., Fulks, Z., and Kolesnick, R. Ceramide synthesis mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell. 52: 405-414, 1995.
39. Cole, S. P. C., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M. V., and Deeley, R. G. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science (Washington DC), 258: 1650-1653, 1992.
40. Grant, C. E., Valdimarsson, G., Hipfner, D. R., Almquist, K. C., Cole, S. P. C., and Deeley, R. G. Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Res., 54: 357-361, 1994.