The nonlysosomal β-glucosidase GBA2 promotes endoplasmic reticulum stress and impairs tumorigenicity of human melanoma cells

FASEB Journal

Volumn 27, Issue 2, 2013, Pages 489-498

  Sorli, Sonia Caroline ^a,b   Colié, Sandra ^a,b   Albinet, Virginie ^a,b   Dubrac, Alexandre ^a,b   Touriol, Christian ^a,b   Guilbaud, Nicolas ^c   Bedia, Carmen ^d   Fabrias, Gemma ^d   Casas, Josefina ^d   Ségui, Bruno ^a,b   Levade, Thierry ^a,b,e   Andrieu Abadie, Nathalie ^d  

^a INSERM   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c INSTITUT DE RECHERCHE PIERRE FABRE   (France)

^d INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

^e TOULOUSE UNIVERSITY HOSPITAL   (France)

Author keywords

Cancer cell death; Glucosylceramide; Glycosylceramidase; Unfolded protein response

Indexed keywords

BETA GLUCOSIDASE; BETA GLUCOSIDASE 2; GLUCOSYLCERAMIDE; GLYCOLIPID; SPHINGOLIPID; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CARCINOGENICITY; CATABOLISM; CELL CULTURE; CELL GROWTH; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VIVO STUDY; LIPID METABOLISM; MASS SPECTROMETRY; MELANOMA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING; XENOGRAFT;

ANIMALS; APOPTOSIS; BETA-GLUCOSIDASE; CELL LINE, TUMOR; CELL PROLIFERATION; CERAMIDES; DOWN-REGULATION; ENDOPLASMIC RETICULUM STRESS; FEMALE; GLUCOSYLCERAMIDES; HUMANS; MELANOMA; MICE; MICE, NUDE; MUTANT PROTEINS; SPHINGOLIPIDS; TRANSPLANTATION, HETEROLOGOUS; UNFOLDED PROTEIN RESPONSE;

EID: 84873447695     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-215152     Document Type: Article

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