Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1831, Issue 2, 2013, Pages 251-262

  Véret, Julien ^a   Coant, Nicolas ^a   Gorshkova, Irina A ^b   Giussani, Paola ^d   Fradet, Magali ^a   Riccitelli, Elena ^d   Skobeleva, Anastasia ^b   Goya, Jonathan ^c   Kassis, Nadim ^a   Natarajan, Viswanathan ^b   Portha, Bernard ^a   Berdyshev, Evgeny V ^b   Le Stunff, Hervé ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

(dihydro)Sphingosine 1 phosphate; Cell death; Ceramides; Gluco lipotoxicity; Pancreatic cells; Type 2 diabetes

Indexed keywords

CASPASE 3; CASPASE 7; CERAMIDE; DIHYDROSPHINGOSINE 1 PHOSPHATE; GLUCOSE; N,N DIMETHYL SPHINGOSINE; PALMITIC ACID; PHOSPHOTRANSFERASE INHIBITOR; SPHINGOID BASE 1 PHOSPHATE; SPHINGOLIPID; SPHINGOSINE KINASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL DEATH; CELL SURVIVAL; CONFOCAL MICROSCOPY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; GENE OVEREXPRESSION; IMMUNOFLUORESCENCE; INSULINOMA; LIPID ANALYSIS; LIPOTOXICITY; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; TUMOR CELL;

ANIMALS; APOPTOSIS; BASE SEQUENCE; CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; DNA PRIMERS; ISLETS OF LANGERHANS; LYSOPHOSPHOLIPIDS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; PALMITIC ACID; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPHINGOSINE; TANDEM MASS SPECTROMETRY;

MAMMALIA; SPHINGOIDEA;

EID: 84868524114     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2012.10.003     Document Type: Article

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