Ceramide triggers caspase activation during γ-radiation-induced apoptosis of human glioma cells lacking functional p53

Oncology Reports

Volumn 12, Issue 1, 2004, Pages 119-123

  Hara, Shigeru ^a   Nakashima, Shigeru ^a   Kiyono, Tohru ^b   Sawada, Motoshi ^a   Yoshimura, Shin Ichi ^a   Iwama, Toru ^a   Sakai, Noboru ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Apoptosis; Caspase; Ceramide; Glioma; p53

Indexed keywords

CASPASE; CERAMIDE; PROTEIN P53;

APOPTOSIS; ARTICLE; DRUG EFFECT; ENZYME ACTIVATION; GAMMA RADIATION; GENETICS; GLIOMA; HUMAN; METABOLISM; PATHOLOGY; RADIATION EXPOSURE; TUMOR CELL LINE;

APOPTOSIS; CASPASES; CELL LINE, TUMOR; CERAMIDES; ENZYME ACTIVATION; GAMMA RAYS; GLIOMA; HUMANS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 21644478540     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.12.1.119     Document Type: Article

References (31)

1. Fine H, Dear K, Loeffler J, Black P and Canellos G: Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer 71: 2585-2597, 1993. (Pubitemid 23100496)
2. Hess C, Schaaf J, Kortmann R, Schabet M and Bamberg M: Malignant glioma: patterns of failure following individually tailored limited volume irradiation. Radiother Oncol 30: 146-149, 1994. (Pubitemid 24101573)
3. Sellers WR and Fisher DE: Apoptosis and cancer drug targeting. J Clin Invest 104: 1655-1661, 1999. (Pubitemid 30053179)
4. Dempke W, Voigt W, Grothey A, Hill BT and Schmoll HJ: Cisplatin resistance and oncogenes - a review. Anticancer Drugs 11: 225-236, 2000. (Pubitemid 30416950)
5. Wolf BB and Green DR: Suicidal tendencies: apoptotic cell death by caspase family proteinases. J Biol Chem 274: 20049-20052, 1999.
6. Hannun YA: Functions of ceramide coordinating cellular responses to stress. Science 274: 1855-1859, 1996.
7. Waldman T, Zhang Y, Dillehay L, Yu J, Kinzler K, Vogelstein B and Williams J: Cell-cycle arrest versus cell death in cancer therapy. Nat Med 3: 1034-1036, 1997. (Pubitemid 27391962)
8. El-Deiry WS: Regulation of p53 downstream genes. Semin Cancer Biol 8: 345-357, 1998.
9. Lowe SW, Ruley HE, Jacks T and Housman DE: p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74: 957-967, 1993. (Pubitemid 23289454)
10. Dbaibo GS, Pushkareva MY, Rachid RA, Alter N, Smyth MJ, Obeid LM and Hannun YA: p53-dependent ceramide response to genotoxic stress. J Clin Invest 102: 329-339, 1998. (Pubitemid 28335192)
11. Sawada M, Nakashima S, Kiyono T, Nakagawa M, Yamada J, Yamakawa H, Banno Y, Shinoda J, Nishimura Y, Nozawa Y and Sakai N: p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells. Oncogene 20: 1368-1378, 2001. (Pubitemid 32269941)
12. Scheffner M, Huibregtse JM, Vierstra RD and Howley PM: The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75: 495-505, 1993. (Pubitemid 23335075)
13. Haas-Kogan DA, Yount G, Haas M, Levi D, Kogan SS, Hu L, Vidair C, Deen DF, Dewey WC and Israel MA: p53-dependent G1 arrest and p53-independent apoptosis influence the radiobiologic response of glioblastoma. Int J Radiat Oncol Biol Phys 36: 95-103, 1996.
14. Tada M, Matsumoto R, Iggo RD, Onimaru R, Shirato H, Sawamura Y and Shinohe Y: Selective sensitivity to radiation of cerebral glioblastomas harboring p53 mutations. Cancer Res 58: 1793-1797, 1998. (Pubitemid 28217448)
15. Sawada M, Nakashima S, Banno Y, Yamakawa H, Hayashi K, Takenaka K, Nishimura Y, Sakai N and Nozawa Y: Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells. Cell Death Differ 7: 761-772, 2000.
16. Sawada M, Nakashima S, Banno Y, Yamakawa H, Takenaka K, Shinoda J, Nishimura Y, Sakai N and Nozawa Y: Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells. Oncogene 19: 3508-3520, 2000. (Pubitemid 30487448)
17. Osawa Y, Banno Y, Nagaki M, Brenner DA, Naiki T, Nozawa Y, Nakashima S and Moriwaki H: TNF-α-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. J Immunol 167: 173-180, 2001. (Pubitemid 32567775)
18. Yoshimura S, Banno Y, Nakashima S, Takenaka K, Sakai H, Nishimura Y, Sakai N, Shimizu S, Eguchi Y, Tsujimoto Y and Nozawa Y: Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. J Biol Chem 273: 6921-6927, 1998.
19. Jaffrezou JP, Levada T, Chatelain P and Laurent G: Modulation of subcellular distribution of doxorubicin in multidrug resistant P388/ADR mouse leukemia cells by the chemosensitizer ((2-isopropyl-1-(4-[3-N-methyl-N-(3,4- dimethoxy-β-phenethyl) amino] propyloxy)-benzenesulfonyl)) indolizine. Cancer Res 52: 6440-6446, 1992.
20. Higuchi M, Singh S, Jaffrezou JP and Aggarwal BB: Acidic sphingomyelinase-generated ceramide is needed but not sufficient for TNF-induced apoptosis and nuclear factor-κB activation. J Immunol 156: 297-304, 1996. (Pubitemid 26190561)
21. Strelow A, Bernardo K, Adam-Klages S, Linke T, Sandhoff K, Kronke M and Adam D: Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death. J Exp Med 192: 601-612, 2000.
22. Lavie Y, Cao H, Bursten SL, Giuliano AE and Cabot MC: Accumulation of glucosylceramides in multidrug-resistant cancer cells J Biol Chem 271: 19530-19536, 1996. (Pubitemid 26271630)
23. Komori H, Ichikawa S, Hirabayashi Y and Ito M: Regulation of intracellular ceramide content in B16 melanoma cells. J Biol Chem 274: 8981-8987, 1999.
24. Santana P, Pena LA, Haimovitz-Friedman A, Martin S, Green D, McLoughlin M, Cordon-Cardo C, Schuchman EH, Fuks Z and Kolesnick R: Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 86: 189-199, 1996. (Pubitemid 26286102)
25. Alphonse G, Aloy MT, Broquet P, Gerard JP, Louisot P, Rousson R and Rodriguez-Lafrasse C: Ceramide induces activation of the mitochondrial/caspases pathway in Jurkat and SCC61 cells sensitive to γ-radiation but activation of this sequence is defective in radioresistant SQ20B cells. Int J Radiat Biol 78: 821-835, 2002.
26. Kimura K, Markowski M, Edsall LC, Spiegel S and Gelmann EP: Role of ceramide in mediating apoptosis of irradiated LNCaP prostate cancer cells. Cell Death Differ 10: 240-248, 2003. (Pubitemid 36553466)
27. Jayadev S, Liu B, Bielawska AE, Lee JY, Nazaire F, Pushkareva MY, Obeid LM and Hannun YA: Role for ceramide in cell cycle arrest. J Biol Chem 270: 2047-2052, 1995.
28. Takeda Y, Tashima M, Takahashi A, Uchiyama T and Okazaki T: Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3. J Biol Chem 274: 10654-10660, 1999.
29. Jaffrezou JP, Levade T, Bettaieb A, Andrieu N, Bezombes C, Maestre N, Vermeersch S, Rousse A and Laurent G: Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis. EMBO J 15: 2417-2424, 1996. (Pubitemid 26151181)
30. Cifone MG, De Maria R, Roncaioli P, Rippo MR, Azuma M, Lanier LL, Santoni A and Testi R: Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J Exp Med 180: 1547-1552, 1994. (Pubitemid 24289629)
31. Schwandner R, Wiegmann K, Bernardo K, Kreder D and Kronke M: TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase. J Biol Chem 273: 5916-5922, 1998. (Pubitemid 28124071) Technology