Acetylation suppresses the proapoptotic activity of GD3 ganglioside

Journal of Experimental Medicine

Volumn 196, Issue 12, 2002, Pages 1535-1541

  Malisan, Florence ^a   Franchi, Luigi ^a   Tomassini, Barbara ^a   Ventura, Natascia ^a   Condò, Ivano ^a   Rippo, Maria Rita ^a   Rufini, Alessandra ^a   Liberati, Laura ^a   Nachtigall, Claudia ^b   Kniep, Bernhard ^b   Testi, Roberto ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

9 O acetyl GD3; Apoptosis; Glioblastoma; Mitochondria; Sialic acid

Indexed keywords

9 O ACETYL GANGLIOSIDE GD3; CASPASE 9; CYTOCHROME C; ESTERASE; GANGLIOSIDE; GANGLIOSIDE GD3; SIALIC ACID; SYNTHETASE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ACETYLATION; APOPTOSIS; ARTICLE; CELL SURVIVAL; ENZYME ACTIVATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; LIPID STORAGE; MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION;

ACETYLATION; ACETYLESTERASE; APOPTOSIS; CASPASES; CELL LINE; ENZYME ACTIVATION; FLOW CYTOMETRY; GANGLIOSIDES; GLYCOSPHINGOLIPIDS; GOLGI APPARATUS; HUMANS; MITOCHONDRIA; N-ACETYLNEURAMINIC ACID; RECEPTORS, CELL SURFACE;

EID: 0037122008     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020960     Document Type: Article

References (37)

1. De Maria, R., M.L. Lenti, F. Malisan, F. d'Agostino, B. Tomassini, A. Zeuner, M.R. Rippo, and R. Testi. 1997. Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis. Science. 277:1652-1655.
2. De Maria, R., M.R. Rippo, H.E. Schuchman, and R. Testi. 1998. Acidic sphingomyelinase (ASM) is necessary for Fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells. J. Exp. Med. 187:897-902.
3. Rippo, M.R., F. Malisan, L. Ravagnan, B. Tomassini, I. Condò, P. Costantini, S.A. Susin, A. Rufini, M. Todaro, G. Kroemer, and R. Testi. 2000. GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion. FASEB J. 14:2047-2054.
4. Scorrano, L., V. Petronilli, F. Di Lisa, and P. Bernardi. 1999. Commitment to apoptosis by GD3 ganglioside depends on opening of the mitochondrial permeability transition pore. J. Biol. Chem. 274:22581-22585.
5. Kristal, B.S., and A.M. Brown. 1999. Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition. J. Biol. Chem. 274:23169-23175.
6. Garcia-Ruiz, C., A. Colell, R. Paris, and J.C. Fernandez-Checa. 2000. Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation. FASEBJ. 14:847-858.
7. Pastorino, J.G., M. Tafani, R.J. Rothman, A. Marcineviciute, J.B. Hoek, and J.L. Farber. 1999. Functional consequences of the sustained or transient activation by bax of the mitochondrial permeability transition pore. J. Biol. Chem. 274:31734-31739.
8. Castro-Palomino, J.C., B. Simon, O. Speer, M. Leist, and R.R. Schmidt. 2001. Synthesis of ganglioside GD3 and its comparison with bovine GD3 with regard to oligodendrocyte apoptosis mitochondrial damage. Chemistry. 7:2178-2184.
9. Varki, A. 1997. Sialic acids as ligands in recognition phenomena. FASEB J. 11:248-255.
10. Klein, A., and P. Roussel. 1998. O-Acetylation of sialic acids. Biochimie. 80:49-57.
11. Schauer, R. 2000. Achievements and challenges of sialic acid research. Glycoconj. J. 17:485-499.
12. Shen, Y., J. Tiralongo, M. Iwersen, B. Sipos, H. Kalthoff, and R. Schauer. 2002. Characterization of the sialate-7(9)-O-acetyltransferase from the microsomes of human colonic mucosa. Biol. Chem. 383:307-317.
13. Varki, A. 1992. Diversity in the sialic acids. Glycobiology. 2:25-40.
14. Cheresh, D.A., R.A. Reisfeld, and A.P. Varki. 1984. O-acetylation of disialoganglioside GD3 by human melanoma cells creates a unique antigenic determinant. Science. 225:844-846.
15. Fuentes, R., R. Allman, and M.D. Mason. 1997. Ganglioside expression in lung cancer cell lines. Lung Cancer. 18:21-33.
16. Fahr, C., and R. Schauer. 2001. Detection of sialic acids and gangliosides with special reference to 9-O-acetylated species in basaliomas and normal human skin. J. Invest. Dermatol. 116:254-260.
17. Takematsu, H., S. Diaz, A. Stoddart, Y. Zhang, and A. Varki. 1999. Lysosomal and cytosolic sialic acid 9-O-acetylesterase activities can be encoded by one gene via differential usage of a signal peptide-encoding exon at the N terminus. J. Biol. Chem. 274:25623-25631.
18. Ariga, T., G.M. Blaine, H. Yoshino, G. Dawson, T. Kanda, G.C. Zeng, T. Kasama, Y. Kushi, and R.K. Yu. 1995. Glycosphingolipid composition of murine neuroblastoma cells: O-acetylesterase gene downregulates the expression of O-acetylated GD3. Biochemistry. 34:11500-11507.
19. Gocht, A., A. Gadatsch, G. Rutter, and B. Kniep. 2000. CDw60: An antigen expressed in many normal tissues and in some tumours. Histochem. J. 32:447-456.
20. Kniep, B., C. Claus, J. Peter-Katalinic, D.A. Monner, W. Dippold, and M. Nimtz. 1995. 7-O-acetyl-GD3 in human T-lymphocytes is detected by a specific T-cell-activating monoclonal antibody. J. Biol. Chem. 270:30173-30180.
21. Claus, C., A. Gocht, R. Schwartz-Albiez, H. Lünsdorf, and B. Kniep. 2002. CD60: Specificity of the antibodies, distribution of the antigens, and the functional aspects. In Leucocyte Typing VII. D. Mason, P. André, A. Bensussan, C. Buckley, C. Civin, E. Clark, M. de Haas, S. Goyert, M. Hadam, D. Hart, et al., editors. Oxford University Press, Oxford, UK. 187-188.
22. Leclerc, N., G.A. Schwarting, K. Herrup, R. Hawkes, and M. Yamamoto. 1992. Compartmentation in mammalian cerebellum: Zebrin II and P-path antibodies define three classes of sagittally organized bands of Purkinje cells. Proc. Natl. Acad. Sci. USA. 89:5006-5010.
23. Kniep, B., J. Peter-Katalinic, W. Flegel, H. Northoff, and E.P. Rieber. 1992. CDw 60 antibodies bind to acetylated forms of ganglioside GD3. Biochem. Biophys. Res. Commun. 187:1343-1349.
24. Kalejta, R.F., T. Shenk, and A.J. Beavis. 1997. Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry. Cytometry. 29:286-291.
25. Reers, M., T.W. Smith, and L.B. Chen. 1991. J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential. Biochemistry. 30:4480-4486.
26. Varki, A., F. Hooshmand, S. Diaz, N.M. Varki, and S.M. Hedrick. 1991. Developmental abnormalities in transgenic mice expressing a sialic acid-specific 9-O-acetylesterase. Cell. 65:65-74.
27. Rosenthal, P.B., X. Zhang, F. Formanowski, W. Fitz, C.H. Wong, H. Meier-Ewert, J.J. Skehel, and D.C. Wiley. 1998. Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza C virus. Nature. 396:92-96.
28. Kolesnick, R.N., F.M. Goni, and A. Alonso. 2000. Compartmentalization of ceramide signaling: Physical foundations and biological effects. J. Cell Physiol. 184:285-300.
29. Hannun, Y. 2000. Ceramide in the eukaryotic stress response. Trends Cell Biol. 10:73-80.
30. Tomassini, B., and R. Testi. 2002. Mitochondria as sensors of sphingolipids. Biochimie. 84:123-129.
31. Sottocornola, E., I. Colombo, V. Vergani, G. Taraboletti, and B. Berra. 1999. Increased tumorigenicity and invasiveness of C6 rat glioma cells transfected with the human alpha-2,8 sialyltransferase cDNA. Invasion Metastasis. 18:142-154.
32. Kouzarides, T. 2000. Acetylation: A regulatory modification to rival phosphorylation? EMBO J. 19:1176-1179.
33. Baker, R.R. 2000. Lipid acetylation reactions and the metabolism of platelet-activating factor. Neurochem. Res. 25:677-683.
34. Vaziri, H., S.K. Dessain, E. Ng-Eaton, S.I. Imai, R.A. Frye, T.K. Pandita, L. Guarente, and R.A. Weinberg. 2001. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell. 107:149-159.
35. Luo, J., F. Su, D. Chen, A. Shiloh, and W. Gu. 2000. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature. 408:377-381.
36. Costanzo, A., P. Merlo, N. Pediconi, M. Fulco, V. Sartorelli, P.A. Cole, G. Fontemaggi, M. Fanciulli, L. Schiltz, G. Blandino, et al. 2001. DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol. Cell. 9:175-186.
37. Chan, H.M., M. Krstic-Demonacos, L. Smith, C. Demonacos, and N.B. La Thangue. 2001. Acetylation control of the retinoblastoma tumour-suppressor protein. Nat. Cell Biol. 3:667-674.