메뉴 건너뛰기




Volumn 205, Issue 2, 2005, Pages 275-292

Molecular mechanisms of drug resistance

Author keywords

Cancer; Chemotherapy; Drug resistance

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; ANTHRACYCLINE; ANTINEOPLASTIC AGENT; CARBOPLATIN; CARRIER PROTEIN; CISPLATIN; CYCLOSPORIN; DNA; DNA TOPOISOMERASE; DOCETAXEL; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; FLUOROURACIL; GLUTATHIONE; GLYCOPROTEIN P; IRINOTECAN; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN; OXALIPLATIN; PACLITAXEL; RALTITREXED; TARIQUIDAR; TAXANE DERIVATIVE; THYMIDYLATE SYNTHASE; TUBULIN; UNINDEXED DRUG; VALSPODAR; VINBLASTINE; VINCA ALKALOID; VINCRISTINE; ZOSUQUIDAR;

EID: 13644254794     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1706     Document Type: Review
Times cited : (1290)

References (253)
  • 1
    • 0027351189 scopus 로고
    • Karnofsky memorial lecture. Ode to methotrexate
    • Bertino JR. Karnofsky memorial lecture. Ode to methotrexate. J Clin Oncol 1993; 11: 5-14.
    • (1993) J. Clin. Oncol. , vol.11 , pp. 5-14
    • Bertino, J.R.1
  • 2
    • 0025997350 scopus 로고
    • ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: A new agent for clinical study
    • Jackman AL, Taylor GA, Gibson W, Kimbell R, Brown M, Calvert AH, et al. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study. Cancer Res 1991; 51: 5579-5586.
    • (1991) Cancer Res. , vol.51 , pp. 5579-5586
    • Jackman, A.L.1    Taylor, G.A.2    Gibson, W.3    Kimbell, R.4    Brown, M.5    Calvert, A.H.6
  • 3
    • 0002545062 scopus 로고    scopus 로고
    • Clinical pharmacology and resistance to dihydrofolate reductase inhibitors
    • Jackman AL (ed). Humana Press: Totowa, NJ
    • Gorlick R, Bertino JR. Clinical pharmacology and resistance to dihydrofolate reductase inhibitors. In Antifolate Drugs in Cancer Therapy, Jackman AL (ed). Humana Press: Totowa, NJ, 1999.
    • (1999) Antifolate Drugs in Cancer Therapy
    • Gorlick, R.1    Bertino, J.R.2
  • 5
    • 0037110469 scopus 로고    scopus 로고
    • Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia
    • Laverdiere C, Chiasson S, Costea I, Moghrabi A, Krajinovic M. Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia. Blood 2002; 100: 3832-3834.
    • (2002) Blood , vol.100 , pp. 3832-3834
    • Laverdiere, C.1    Chiasson, S.2    Costea, I.3    Moghrabi, A.4    Krajinovic, M.5
  • 6
    • 0037377560 scopus 로고    scopus 로고
    • Decreased expression of the reduced folate carrier and folylpolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line
    • Wang Y, Zhao R, Goldman ID. Decreased expression of the reduced folate carrier and folylpolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line. Biochem Pharmacol 2003; 65: 1163-1170.
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 1163-1170
    • Wang, Y.1    Zhao, R.2    Goldman, I.D.3
  • 7
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman MM, Fojo T, Bates SE. Multidrug resistance in cancer: role of ATP-dependent transporters. Nature Rev Cancer 2002; 2: 48-58.
    • (2002) Nature Rev. Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 9
    • 0037358040 scopus 로고    scopus 로고
    • Overcoming multidrug resistance in cancer: An update on the clinical strategy of inhibiting p-glycoprotein
    • Thomas H, Coley HM. Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein. Cancer Control 2003; 10: 159-165.
    • (2003) Cancer Control , vol.10 , pp. 159-165
    • Thomas, H.1    Coley, H.M.2
  • 10
    • 0033799839 scopus 로고    scopus 로고
    • Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs
    • Krishna R, Mayer LD. Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur J Pharm Sci 2000; 11: 265-283.
    • (2000) Eur. J. Pharm. Sci. , vol.11 , pp. 265-283
    • Krishna, R.1    Mayer, L.D.2
  • 11
    • 0037453894 scopus 로고    scopus 로고
    • Multidrug resistance: Can new drugs help chemotherapy score against cancer?
    • Goldman B. Multidrug resistance: can new drugs help chemotherapy score against cancer? J Natl Cancer Inst 2003; 95 255-257.
    • (2003) J. Natl. Cancer Inst. , vol.95 , pp. 255-257
    • Goldman, B.1
  • 12
    • 0033593855 scopus 로고    scopus 로고
    • Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives
    • Roe M, Folkes A, Ashworth P, Brumwell J, Chima L, Hunjan S, et al. Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives. Bioorg Med Chem Lett 1999; 9 595-600.
    • (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 595-600
    • Roe, M.1    Folkes, A.2    Ashworth, P.3    Brumwell, J.4    Chima, L.5    Hunjan, S.6
  • 13
    • 0030769833 scopus 로고    scopus 로고
    • Pharmacological characterization of LY335979: A potent cyclopropyldibenzosuberane modulator of P-glycoprotein
    • Starling JJ, Shepard RL, Cao J, Law KL, Norman BH, Kroin JS, et al. Pharmacological characterization of LY335979: a potent cyclopropyldibenzosuberane modulator of P-glycoprotein. Adv Enzyme Regul 1997; 37: 335-347.
    • (1997) Adv. Enzyme Regul. , vol.37 , pp. 335-347
    • Starling, J.J.1    Shepard, R.L.2    Cao, J.3    Law, K.L.4    Norman, B.H.5    Kroin, J.S.6
  • 14
    • 0024595925 scopus 로고
    • Clinical pharmacology of 5-fluorouracil
    • Diasio RB, Harris BE. Clinical pharmacology of 5-fluorouracil. Clin Pharmacokinet 1989; 16: 215-237.
    • (1989) Clin. Pharmacokinet. , vol.16 , pp. 215-237
    • Diasio, R.B.1    Harris, B.E.2
  • 15
    • 0035213225 scopus 로고    scopus 로고
    • Retroviral transduction of human dihydropyrimidine dehydrogenase cDNA confers resistance to 5-fluorouracil in murine hematopoietic progenitor cells and human CD34+-enriched peripheral blood progenitor cells
    • Takebe N, Zhao SC, Ural AU, Johnson MR, Banerjee D, Diasio RB, et al. Retroviral transduction of human dihydropyrimidine dehydrogenase cDNA confers resistance to 5-fluorouracil in murine hematopoietic progenitor cells and human CD34+-enriched peripheral blood progenitor cells. Cancer Gene Ther 2001; 8: 966-973.
    • (2001) Cancer Gene Ther. , vol.8 , pp. 966-973
    • Takebe, N.1    Zhao, S.C.2    Ural, A.U.3    Johnson, M.R.4    Banerjee, D.5    Diasio, R.B.6
  • 16
    • 0034048729 scopus 로고    scopus 로고
    • Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase
    • Salonga D, Danenberg KD, Johnson M, Metzger R, Groshen S, Tsao-Wei DD, et al. Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin Cancer Res 2000; 6: 1322-1327.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 1322-1327
    • Salonga, D.1    Danenberg, K.D.2    Johnson, M.3    Metzger, R.4    Groshen, S.5    Tsao-Wei, D.D.6
  • 18
    • 0027305406 scopus 로고
    • Glutathione-associated cis-diammine-dichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance
    • Ishikawa T, Ali-Osman F. Glutathione-associated cis diammine-dichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. J Biol Chem 1993; 268 20 116-20 125.
    • (1993) J. Biol. Chem. , vol.268 , pp. 20116-20125
    • Ishikawa, T.1    Ali-Osman, F.2
  • 19
    • 0027748224 scopus 로고
    • New platinum antitumor complexes
    • Kelland LR. New platinum antitumor complexes. Crit Rev Oncol Hematol 1993; 15: 191-219.
    • (1993) Crit. Rev. Oncol. Hematol. , vol.15 , pp. 191-219
    • Kelland, L.R.1
  • 20
    • 0035750278 scopus 로고    scopus 로고
    • Analysis of gene expression profiles associated with cisplatin resistance in human ovarian cancer cell lines and tissues using cDNA microarray
    • Sakamoto M, Kondo A, Kawasaki K, Goto T, Sakamoto H, Miyake K, et al. Analysis of gene expression profiles associated with cisplatin resistance in human ovarian cancer cell lines and tissues using cDNA microarray. Hum Cell 2001; 14: 305-315.
    • (2001) Hum. Cell , vol.14 , pp. 305-315
    • Sakamoto, M.1    Kondo, A.2    Kawasaki, K.3    Goto, T.4    Sakamoto, H.5    Miyake, K.6
  • 21
    • 0346365372 scopus 로고    scopus 로고
    • Glutathione S-transferase pi amplification is associated with cisplatin resistance in head and neck squamous cell carcinoma cell lines and primary tumors
    • Cullen KJ, Newkirk KA, Schumaker LM, Aldosari N, Rone JD, Haddad BR. Glutathione S-transferase pi amplification is associated with cisplatin resistance in head and neck squamous cell carcinoma cell lines and primary tumors. Cancer Res 2003; 63: 8097-8102.
    • (2003) Cancer Res. , vol.63 , pp. 8097-8102
    • Cullen, K.J.1    Newkirk, K.A.2    Schumaker, L.M.3    Aldosari, N.4    Rone, J.D.5    Haddad, B.R.6
  • 22
    • 0027250219 scopus 로고
    • Glutathione S-transferase expression in benign and malignant ovarian tumours
    • Green JA, Robertson LJ, Clark AH. Glutathione S-transferase expression in benign and malignant ovarian tumours. Br J Cancer 1993; 68: 235-239.
    • (1993) Br. J. Cancer , vol.68 , pp. 235-239
    • Green, J.A.1    Robertson, L.J.2    Clark, A.H.3
  • 23
    • 0033395108 scopus 로고    scopus 로고
    • Prognostic value of p53, glutathione S-transferase pi, and thymidylate synthase for neoadjuvant cisplatin-based chemotherapy in head and neck cancer
    • Shiga H, Heath EI, Rasmussen AA, Trock B, Johnston PG, Forastiere AA, et al. Prognostic value of p53, glutathione S-transferase pi, and thymidylate synthase for neoadjuvant cisplatin-based chemotherapy in head and neck cancer. Clin Cancer Res 1999; 5: 4097-4104.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 4097-4104
    • Shiga, H.1    Heath, E.I.2    Rasmussen, A.A.3    Trock, B.4    Johnston, P.G.5    Forastiere, A.A.6
  • 24
    • 0345256652 scopus 로고    scopus 로고
    • Cisplatin: Mode of cytotoxic action and molecular basis of resistance
    • Siddik ZH. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 2003; 22: 7265-7279.
    • (2003) Oncogene , vol.22 , pp. 7265-7279
    • Siddik, Z.H.1
  • 25
    • 0025781307 scopus 로고
    • Metallothionein content correlates with the sensitivity of human small cell lung cancer cell lines to cisplatin
    • Kasahara K, Fujiwara Y, Nishio K, Ohmori T, Sugimoto Y, Komiya K, et al. Metallothionein content correlates with the sensitivity of human small cell lung cancer cell lines to cisplatin. Cancer Res 1991; 51: 3237-3242.
    • (1991) Cancer Res. , vol.51 , pp. 3237-3242
    • Kasahara, K.1    Fujiwara, Y.2    Nishio, K.3    Ohmori, T.4    Sugimoto, Y.5    Komiya, K.6
  • 28
    • 0025754226 scopus 로고
    • Metallothionein levels in ovarian tumours before and after chemotherapy
    • Murphy D, McGown AT, Crowther D, Mander A, Fox BW. Metallothionein levels in ovarian tumours before and after chemotherapy. Br J Cancer 1991; 63: 711-714.
    • (1991) Br. J. Cancer , vol.63 , pp. 711-714
    • Murphy, D.1    McGown, A.T.2    Crowther, D.3    Mander, A.4    Fox, B.W.5
  • 29
    • 0033806025 scopus 로고    scopus 로고
    • Mechanisms of drug resistance to the platinum complex ZD0473 in ovarian cancer cell lines
    • Holford J, Beale PJ, Boxall FE, Sharp SY, Kelland LR. Mechanisms of drug resistance to the platinum complex ZD0473 in ovarian cancer cell lines. Eur J Cancer 2000; 36: 1984-1990.
    • (2000) Eur. J. Cancer , vol.36 , pp. 1984-1990
    • Holford, J.1    Beale, P.J.2    Boxall, F.E.3    Sharp, S.Y.4    Kelland, L.R.5
  • 30
    • 0036924112 scopus 로고    scopus 로고
    • Irinotecan: Mechanisms of tumor resistance and novel strategies for modulating its activity
    • Xu Y, Villalona-Calero MA. Irinotecan: mechanisms of tumor resistance and novel strategies for modulating its activity. Ann Oncol 2002; 13: 1841-1851.
    • (2002) Ann. Oncol. , vol.13 , pp. 1841-1851
    • Xu, Y.1    Villalona-Calero, M.A.2
  • 32
    • 4143101374 scopus 로고    scopus 로고
    • Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: A molecular and clinical study of 75 patients
    • Rouits E, Boisdron-Celle M, Dumont A, Guerin O, Morel A, Gamelin E. Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: a molecular and clinical study of 75 patients. Clin Cancer Res 2004; 10: 5151-5159.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 5151-5159
    • Rouits, E.1    Boisdron-Celle, M.2    Dumont, A.3    Guerin, O.4    Morel, A.5    Gamelin, E.6
  • 33
    • 1642327569 scopus 로고    scopus 로고
    • Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin and irinotecan
    • Boyer J, McLean EG, Aroori S, Wilson P, McCulla A, Carey PD, et al. Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin and irinotecan. Clin Cancer Res 2004; 10: 2158-2167.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 2158-2167
    • Boyer, J.1    McLean, E.G.2    Aroori, S.3    Wilson, P.4    McCulla, A.5    Carey, P.D.6
  • 34
    • 0032188839 scopus 로고    scopus 로고
    • Reversal of CPT-11 resistance of lung cancer cells by adenovirus-mediated gene transfer of the human carboxylesterase cDNA
    • Kojima A, Hackett NR, Crystal RG. Reversal of CPT-11 resistance of lung cancer cells by adenovirus-mediated gene transfer of the human carboxylesterase cDNA. Cancer Res 1998; 58: 4368-4374.
    • (1998) Cancer Res. , vol.58 , pp. 4368-4374
    • Kojima, A.1    Hackett, N.R.2    Crystal, R.G.3
  • 36
    • 0020563004 scopus 로고
    • Elucidation of pathways of 5-fluorouracil metabolism in xenografts of human colorectal adenocarcinoma
    • Houghton JA, Houghton PJ. Elucidation of pathways of 5-fluorouracil metabolism in xenografts of human colorectal adenocarcinoma. Eur J Cancer Clin Oncol 1983; 19: 807-815.
    • (1983) Eur. J. Cancer Clin. Oncol. , vol.19 , pp. 807-815
    • Houghton, J.A.1    Houghton, P.J.2
  • 37
    • 0032797555 scopus 로고    scopus 로고
    • Increased cytotoxicity and bystander effect of 5-fluorouracil and 5-deoxy-5-fluorouridine in human colorectal cancer cells transfected with thymidine phosphorylase
    • Evrard A, Cuq P, Ciccolini J, Vian L, Cano JP. Increased cytotoxicity and bystander effect of 5-fluorouracil and 5-deoxy-5-fluorouridine in human colorectal cancer cells transfected with thymidine phosphorylase. Br J Cancer 1999; 80: 1726-1733.
    • (1999) Br. J. Cancer , vol.80 , pp. 1726-1733
    • Evrard, A.1    Cuq, P.2    Ciccolini, J.3    Vian, L.4    Cano, J.P.5
  • 38
    • 0002558742 scopus 로고    scopus 로고
    • Raltitrexed (tomudex), a highly polyglutamatable antifolate thymidylate synthase inhibitor
    • Jackman AL (ed). Humana Press: Totowa, NJ
    • Hughes LR, Stephens TC, Boyle FT. Raltitrexed (tomudex), a highly polyglutamatable antifolate thymidylate synthase inhibitor. In Antifolate Drugs in Cancer Therapy, Jackman AL (ed). Humana Press: Totowa, NJ, 1999; 147-165.
    • (1999) Antifolate Drugs in Cancer Therapy , pp. 147-165
    • Hughes, L.R.1    Stephens, T.C.2    Boyle, F.T.3
  • 39
    • 0032882886 scopus 로고    scopus 로고
    • Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines
    • Barnes MJ, Estlin EJ, Taylor GA, Aherne GW, Hardcastle A, McGuire JJ, et al. Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines. Clin Cancer Res 1999; 5: 2548-2558.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2548-2558
    • Barnes, M.J.1    Estlin, E.J.2    Taylor, G.A.3    Aherne, G.W.4    Hardcastle, A.5    McGuire, J.J.6
  • 40
    • 0002022109 scopus 로고    scopus 로고
    • Fluoropyrimidines as antifolate drugs
    • Jackman AL (ed). Humana Press: Totowa, NJ
    • Peters GJ, Kohne CH. Fluoropyrimidines as antifolate drugs. In Antifolate Drugs in Cancer Therapy, Jackman AL (ed). Humana Press: Totowa, NJ, 1999.
    • (1999) Antifolate Drugs in Cancer Therapy
    • Peters, G.J.1    Kohne, C.H.2
  • 41
    • 0038387494 scopus 로고    scopus 로고
    • 5-Fluorouracil: Mechanisms of action and clinical strategies
    • Longley DB, Harkin DP, Johnston PG. 5-Fluorouracil: mechanisms of action and clinical strategies. Nature Rev Cancer 2003; 3: 330-338.
    • (2003) Nature Rev. Cancer , vol.3 , pp. 330-338
    • Longley, D.B.1    Harkin, D.P.2    Johnston, P.G.3
  • 42
    • 0028940399 scopus 로고
    • Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
    • Johnston PG, Lenz HJ, Leichman CG, Danenberg KD, Allegra CJ, Danenberg PV, et al. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 1995; 55: 1407-1412.
    • (1995) Cancer Res. , vol.55 , pp. 1407-1412
    • Johnston, P.G.1    Lenz, H.J.2    Leichman, C.G.3    Danenberg, K.D.4    Allegra, C.J.5    Danenberg, P.V.6
  • 43
    • 14444285483 scopus 로고    scopus 로고
    • p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: An analysis of response and survival
    • Lenz HJ, Hayashi K, Salonga D, Danenberg KD, Danenberg PV, Metzger R, et al. p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival. Clin Cancer Res 1998; 4: 1243-1250.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 1243-1250
    • Lenz, H.J.1    Hayashi, K.2    Salonga, D.3    Danenberg, K.D.4    Danenberg, P.V.5    Metzger, R.6
  • 44
    • 0035522659 scopus 로고    scopus 로고
    • Thymidylate synthase pharmacogenomics in colorectal cancer
    • Marsh S, McLeod HL. Thymidylate synthase pharmacogenomics in colorectal cancer. Clin Colorectal Cancer 2001; 1: 175-178.
    • (2001) Clin. Colorectal Cancer , vol.1 , pp. 175-178
    • Marsh, S.1    McLeod, H.L.2
  • 45
    • 0027416220 scopus 로고
    • Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma
    • Chu E, Koeller DM, Johnston PG, Zinn S, Allegra CJ. Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma. Mol Pharmacol 1993; 43 527-533.
    • (1993) Mol. Pharmacol. , vol.43 , pp. 527-533
    • Chu, E.1    Koeller, D.M.2    Johnston, P.G.3    Zinn, S.4    Allegra, C.J.5
  • 47
    • 0028031680 scopus 로고
    • Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells
    • Chu E, Voeller DM, Jones KL, Takechi T, Maley GF, Maley F, et al. Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells. Mol Cell Biol 1994; 14: 207-213.
    • (1994) Mol. Cell Biol. , vol.14 , pp. 207-213
    • Chu, E.1    Voeller, D.M.2    Jones, K.L.3    Takechi, T.4    Maley, G.F.5    Maley, F.6
  • 48
    • 0035176182 scopus 로고    scopus 로고
    • Characterization of a thymidylate synthase (TS)-inducible cell line: A model system for studying sensitivity to TS- and non-TS-targeted chemotherapies
    • Longley DB, Ferguson PR, Boyer J, Latif T, Lynch M, Maxwell P, et al. Characterization of a thymidylate synthase (TS -inducible cell line: a model system for studying sensitivity to TS- and non-TS-targeted chemotherapies. Clin Cancer Res 2001; 7: 3533-3539.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3533-3539
    • Longley, D.B.1    Ferguson, P.R.2    Boyer, J.3    Latif, T.4    Lynch, M.5    Maxwell, P.6
  • 49
    • 0036570007 scopus 로고    scopus 로고
    • The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates
    • Longley DB, Boyer J, Allen WL, Latif T, Ferguson PR, Maxwell PJ, et al. The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates. Cancer Res 2002; 62: 2644-2649.
    • (2002) Cancer Res. , vol.62 , pp. 2644-2649
    • Longley, D.B.1    Boyer, J.2    Allen, W.L.3    Latif, T.4    Ferguson, P.R.5    Maxwell, P.J.6
  • 52
    • 0030469352 scopus 로고    scopus 로고
    • Identification of topoisomerase I mutations affecting both DNA cleavage and interaction with camptothecin
    • Li XG, Haluska P Jr, Hsiang YH, Bharti A, Kufe DW, Rubin EH. Identification of topoisomerase I mutations affecting both DNA cleavage and interaction with camptothecin. Ann N Y Acad Sci 1996; 803 111-127.
    • (1996) Ann. N Y Acad. Sci. , vol.803 , pp. 111-127
    • Li, X.G.1    Haluska Jr., P.2    Hsiang, Y.H.3    Bharti, A.4    Kufe, D.W.5    Rubin, E.H.6
  • 53
    • 0035062017 scopus 로고    scopus 로고
    • Topoisomerase I-DNA covalent complexes in human colorectal cancer xenografts with different p53 and microsatellite instability status: Relation with their sensitivity to CTP-11
    • Lansiaux A, Bras-Goncalves RA, Rosty C, Laurent-Puig P, Poupon MF, Bailly C. Topoisomerase I-DNA covalent complexes in human colorectal cancer xenografts with different p53 and microsatellite instability status: relation with their sensitivity to CTP-11. Anticancer Res 2001; 21: 471-476.
    • (2001) Anticancer Res. , vol.21 , pp. 471-476
    • Lansiaux, A.1    Bras-Goncalves, R.A.2    Rosty, C.3    Laurent-Puig, P.4    Poupon, M.F.5    Bailly, C.6
  • 54
    • 0026857985 scopus 로고
    • Multifactorial resistance to antineoplastic agents in drug-resistant P388 murine leukemia, Chinese hamster ovary, and human HeLa cells, with emphasis on the role of DNA topoisomerase II
    • Deffie AM, McPherson JP, Gupta RS, Hedley DW, Goldenberg GJ. Multifactorial resistance to antineoplastic agents in drug-resistant P388 murine leukemia, Chinese hamster ovary, and human HeLa cells, with emphasis on the role of DNA topoisomerase II. Biochem Cell Biol 1992; 70: 354-364.
    • (1992) Biochem. Cell Biol. , vol.70 , pp. 354-364
    • Deffie, A.M.1    McPherson, J.P.2    Gupta, R.S.3    Hedley, D.W.4    Goldenberg, G.J.5
  • 55
    • 0026048306 scopus 로고
    • Decreased DNA topoisomerase II in daunorubicin-resistant Ehrlich ascites tumor cells
    • Friche E, Danks MK, Schmidt CA, Beck WT. Decreased DNA topoisomerase II in daunorubicin-resistant Ehrlich ascites tumor cells. Cancer Res 1991; 51: 4213-4218.
    • (1991) Cancer Res. , vol.51 , pp. 4213-4218
    • Friche, E.1    Danks, M.K.2    Schmidt, C.A.3    Beck, W.T.4
  • 56
    • 1942438028 scopus 로고    scopus 로고
    • Microtubules as a target for anticancer drugs
    • Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nature Rev Cancer 2004; 4: 253-265.
    • (2004) Nature Rev. Cancer , vol.4 , pp. 253-265
    • Jordan, M.A.1    Wilson, L.2
  • 57
    • 0030020158 scopus 로고    scopus 로고
    • Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death
    • Jordan MA, Wendell K, Gardiner S, Derry WB, Copp H, Wilson L. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 1996; 56: 816-825.
    • (1996) Cancer Res. , vol.56 , pp. 816-825
    • Jordan, M.A.1    Wendell, K.2    Gardiner, S.3    Derry, W.B.4    Copp, H.5    Wilson, L.6
  • 58
    • 0027360552 scopus 로고
    • Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations
    • Jordan MA, Toso RJ, Thrower D, Wilson L. Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. Proc Natl Acad Sci U S A 1993; 90: 9552-9556.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 9552-9556
    • Jordan, M.A.1    Toso, R.J.2    Thrower, D.3    Wilson, L.4
  • 59
    • 0033052777 scopus 로고    scopus 로고
    • Mechanisms of action of and resistance to antitubulin agents: Microtubule dynamics, drug transport, and cell death
    • Dumontet C, Sikic BI. Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death. J Clin Oncol 1999; 17: 1061-1070.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 1061-1070
    • Dumontet, C.1    Sikic, B.I.2
  • 60
    • 0035422780 scopus 로고    scopus 로고
    • Multiple microtubule alterations are associated with vinca alkaloid resistance in human leukemia cells
    • Kavallaris M, Tait AS, Walsh BJ, He L, Horwitz SB, Norris MD, et al. Multiple microtubule alterations are associated with vinca alkaloid resistance in human leukemia cells. Cancer Res 2001; 61 5803-5809.
    • (2001) Cancer Res. , vol.61 , pp. 5803-5809
    • Kavallaris, M.1    Tait, A.S.2    Walsh, B.J.3    He, L.4    Horwitz, S.B.5    Norris, M.D.6
  • 62
    • 0030758777 scopus 로고    scopus 로고
    • Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization
    • Giannakakou P, Sackett DL, Kang YK, Zhan Z, Buters JT, Fojo T, et al. Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization. J Biol Chem 1997; 272: 17 118 -17 125.
    • (1997) J. Biol. Chem. , vol.272 , pp. 17118-17125
    • Giannakakou, P.1    Sackett, D.L.2    Kang, Y.K.3    Zhan, Z.4    Buters, J.T.5    Fojo, T.6
  • 63
    • 0033566758 scopus 로고    scopus 로고
    • Efficient nucleotide excision repair of cisplatin, oxaliplatin, and bis-aceto-ammine-dichloro-cyclohexylamine-platinum(IV) (JM216) platinum intrastrand DNA diadducts
    • Reardon JT, Vaisman A, Chaney SG, Sancar A. Efficient nucleotide excision repair of cisplatin, oxaliplatin, and bis-aceto-ammine-dichloro-cyclohexylamine-platinum(IV) (JM216) platinum intrastrand DNA diadducts. Cancer Res 1999; 59: 3968-3971.
    • (1999) Cancer Res. , vol.59 , pp. 3968-3971
    • Reardon, J.T.1    Vaisman, A.2    Chaney, S.G.3    Sancar, A.4
  • 64
    • 0029762815 scopus 로고    scopus 로고
    • DNA repair: Enzymatic mechanisms and relevance to drug response
    • Chaney SG, Sancar A. DNA repair: enzymatic mechanisms and relevance to drug response. J Natl Cancer Inst 1996; 88: 1346-1360.
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 1346-1360
    • Chaney, S.G.1    Sancar, A.2
  • 65
    • 0036732039 scopus 로고    scopus 로고
    • Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells
    • Furuta T, Ueda T, Aune G, Sarasin A, Kraemer KH, Pommier Y. Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells. Cancer Res 2002; 62: 4899-4902.
    • (2002) Cancer Res. , vol.62 , pp. 4899-4902
    • Furuta, T.1    Ueda, T.2    Aune, G.3    Sarasin, A.4    Kraemer, K.H.5    Pommier, Y.6
  • 66
    • 0031791029 scopus 로고    scopus 로고
    • Platinum-DNA adduct, nucleotide excision repair and platinum based anti-cancer chemotherapy
    • Reed E. Platinum-DNA adduct, nucleotide excision repair and platinum based anti-cancer chemotherapy. Cancer Treat Rev 1998; 24: 331-344.
    • (1998) Cancer Treat. Rev. , vol.24 , pp. 331-344
    • Reed, E.1
  • 67
    • 0027372625 scopus 로고
    • Cisplatin sensitivity/resistance in UV repair-deficient Chinese hamster ovary cells of complementation groups 1 and 3
    • Lee KB, Parker RJ, Bohr V, Cornelison T, Reed E. Cisplatin sensitivity/resistance in UV repair-deficient Chinese hamster ovary cells of complementation groups 1 and 3. Carcinogenesis 1993; 14: 2177-2180.
    • (1993) Carcinogenesis , vol.14 , pp. 2177-2180
    • Lee, K.B.1    Parker, R.J.2    Bohr, V.3    Cornelison, T.4    Reed, E.5
  • 68
    • 0031883776 scopus 로고    scopus 로고
    • Cells from ERCC1-deficient mice show increased genome instability and a reduced frequency of S-phase-dependent illegitimate chromosome exchange but a normal frequency of homologous recombination
    • Melton DW, Ketchen AM, Nunez F, Bonatti-Abbondandolo S, Abbondandolo A, Squires S, et al. Cells from ERCC1-deficient mice show increased genome instability and a reduced frequency of S-phase-dependent illegitimate chromosome exchange but a normal frequency of homologous recombination. J Cell Sci 1998; 111: 395-404.
    • (1998) J. Cell Sci. , vol.111 , pp. 395-404
    • Melton, D.W.1    Ketchen, A.M.2    Nunez, F.3    Bonatti-Abbondandolo, S.4    Abbondandolo, A.5    Squires, S.6
  • 69
    • 3142773418 scopus 로고    scopus 로고
    • Oncogenic H-Ras up-regulates expression of ERCC1 to protect cells from platinum-based anticancer agents
    • Youn CK, Kim MH, Cho HJ, Kim HB, Chang IY, Chung MH, et al. Oncogenic H-Ras up-regulates expression of ERCC1 to protect cells from platinum-based anticancer agents. Cancer Res 2004; 64: 4849-4857.
    • (2004) Cancer Res. , vol.64 , pp. 4849-4857
    • Youn, C.K.1    Kim, M.H.2    Cho, H.J.3    Kim, H.B.4    Chang, I.Y.5    Chung, M.H.6
  • 70
    • 0037444279 scopus 로고    scopus 로고
    • Enhanced cisplatin cytotoxicity by disturbing the nucleotide excision repair pathway in ovarian cancer cell lines
    • Selvakumaran M, Pisarcik DA, Bao R, Yeung AT, Hamilton TC. Enhanced cisplatin cytotoxicity by disturbing the nucleotide excision repair pathway in ovarian cancer cell lines. Cancer Res 2003; 63 1311-1316.
    • (2003) Cancer Res. , vol.63 , pp. 1311-1316
    • Selvakumaran, M.1    Pisarcik, D.A.2    Bao, R.3    Yeung, A.T.4    Hamilton, T.C.5
  • 71
    • 0028141961 scopus 로고
    • Messenger RNA levels of XPAC and ERCC1 in ovarian cancer tissue correlate with response to platinum-based chemotherapy
    • Dabholkar M, Vionnet J, Bostick-Bruton F, Yu JJ, Reed E. Messenger RNA levels of XPAC and ERCC1 in ovarian cancer tissue correlate with response to platinum-based chemotherapy. J Clin Invest 1994; 94: 703-708.
    • (1994) J. Clin. Invest. , vol.94 , pp. 703-708
    • Dabholkar, M.1    Vionnet, J.2    Bostick-Bruton, F.3    Yu, J.J.4    Reed, E.5
  • 72
    • 0031982522 scopus 로고    scopus 로고
    • ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving, combination cisplatin and fluorouracil chemotherapy
    • Metzger R, Leichman CG, Danenberg KD, Danenberg PV, Lenz HJ, Hayashi K, et al. ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving, combination cisplatin and fluorouracil chemotherapy. J Clin Oncol 1998; 16: 309-316.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 309-316
    • Metzger, R.1    Leichman, C.G.2    Danenberg, K.D.3    Danenberg, P.V.4    Lenz, H.J.5    Hayashi, K.6
  • 73
    • 0035988959 scopus 로고    scopus 로고
    • Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer
    • Lord RV, Brabender J, Gandara D, Alberola V, Camps C, Domine M, et al. Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer. Clin Cancer Res 2002; 8: 2286-2291.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 2286-2291
    • Lord, R.V.1    Brabender, J.2    Gandara, D.3    Alberola, V.4    Camps, C.5    Domine, M.6
  • 74
    • 0035576102 scopus 로고    scopus 로고
    • ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy
    • Shirota Y, Stoehlmacher J, Brabender J, Xiong YP, Uetake H, Danenberg KD, et al. ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy. J Clin Oncol 2001; 19 4298-4304.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 4298-4304
    • Shirota, Y.1    Stoehlmacher, J.2    Brabender, J.3    Xiong, Y.P.4    Uetake, H.5    Danenberg, K.D.6
  • 75
    • 0028982818 scopus 로고
    • Ratio of 2′-deoxyadenosine-5′-triphosphate/thymidine-5′ -triphosphate influences the commitment of human colon carcinoma cells to thymineless death
    • Houghton JA, Tillman DM, Harwood FG. Ratio of 2′-deoxyadenosine-5′-triphosphate/thymidine-5′ -triphosphate influences the commitment of human colon carcinoma cells to thymineless death. Clin Cancer Res 1995; 1: 723-730.
    • (1995) Clin. Cancer Res. , vol.1 , pp. 723-730
    • Houghton, J.A.1    Tillman, D.M.2    Harwood, F.G.3
  • 76
    • 0003267529 scopus 로고    scopus 로고
    • Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells
    • Aherne GW, Hardcastle A, Raynaud F, Jackman AL. Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells. Biochem Pharmacol 1996; 51: 1293-1301.
    • (1996) Biochem. Pharmacol. , vol.51 , pp. 1293-1301
    • Aherne, G.W.1    Hardcastle, A.2    Raynaud, F.3    Jackman, A.L.4
  • 77
    • 0000476915 scopus 로고
    • An N-glycosidase from Escherichia coli that releases free uracil from DNA containing deaminated cytosine residues
    • Lindahl T. An N-glycosidase from Escherichia coli that releases free uracil from DNA containing deaminated cytosine residues. Proc Natl Acad Sci U S A 1974; 71: 3649-3653.
    • (1974) Proc. Natl. Acad. Sci. U. S. A. , vol.71 , pp. 3649-3653
    • Lindahl, T.1
  • 78
    • 0035217760 scopus 로고    scopus 로고
    • The role of dUTPase and uracil-DNA repair in cancer chemotherapy
    • Ladner RD. The role of dUTPase and uracil-DNA repair in cancer chemotherapy. Curr Protein Pept Sci 2001; 2: 361-370.
    • (2001) Curr. Protein Pept. Sci. , vol.2 , pp. 361-370
    • Ladner, R.D.1
  • 79
    • 0033811850 scopus 로고    scopus 로고
    • Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331
    • Webley SD, Hardcastle A, Ladner RD, Jackman AL, Aherne GW. Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331. Br J Cancer 2000; 83 792-799.
    • (2000) Br. J. Cancer , vol.83 , pp. 792-799
    • Webley, S.D.1    Hardcastle, A.2    Ladner, R.D.3    Jackman, A.L.4    Aherne, G.W.5
  • 80
    • 0037063173 scopus 로고    scopus 로고
    • Novel gain of function activity of p53 mutants: Activation of the dUTPase gene expression leading to resistance to 5-fluorouracil
    • Pugacheva EN, Ivanov AV, Kravchenko JE, Kopnin BP, Levine AJ, Chumakov PM. Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil. Oncogene 2002; 21: 4595-4600.
    • (2002) Oncogene , vol.21 , pp. 4595-4600
    • Pugacheva, E.N.1    Ivanov, A.V.2    Kravchenko, J.E.3    Kopnin, B.P.4    Levine, A.J.5    Chumakov, P.M.6
  • 81
    • 0035800492 scopus 로고    scopus 로고
    • The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition
    • Webley SD, Welsh SJ, Jackman AL, Aherne GW. The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition. Br J Cancer 2001; 85: 446-452.
    • (2001) Br. J. Cancer , vol.85 , pp. 446-452
    • Webley, S.D.1    Welsh, S.J.2    Jackman, A.L.3    Aherne, G.W.4
  • 82
    • 0024548544 scopus 로고
    • Enhancement of 5-fluorouracil's anticancer activity by dipyridamole
    • Grem JL, Fischer PH. Enhancement of 5-fluorouracil's anticancer activity by dipyridamole. Pharmacol Ther 1989; 40: 349-371.
    • (1989) Pharmacol. Ther. , vol.40 , pp. 349-371
    • Grem, J.L.1    Fischer, P.H.2
  • 83
    • 0033928171 scopus 로고    scopus 로고
    • The epigenetics of colorectal cancer
    • discussion 153-155
    • Issa JP. The epigenetics of colorectal cancer. Ann N Y Acad Sci 2000; 910: 140-153; discussion 153-155.
    • (2000) Ann. N Y Acad. Sci. , vol.910 , pp. 140-153
    • Issa, J.P.1
  • 85
    • 0029838414 scopus 로고    scopus 로고
    • Microsatellite instability correlates with reduced survival and poor disease prognosis in breast cancer
    • Paulson TG, Wright FA, Parker BA, Russack V, Wahl GM. Microsatellite instability correlates with reduced survival and poor disease prognosis in breast cancer. Cancer Res 1996; 56: 4021-4026.
    • (1996) Cancer Res. , vol.56 , pp. 4021-4026
    • Paulson, T.G.1    Wright, F.A.2    Parker, B.A.3    Russack, V.4    Wahl, G.M.5
  • 86
    • 0032969319 scopus 로고    scopus 로고
    • A specific CpG methylation pattern of the MGMT promoter region associated with reduced MGMT expression in primary colorectal cancers
    • Herfarth KK, Brent TP, Danam RP, Remack JS, Kodner IJ, Wells SA Jr, et al. A specific CpG methylation pattern of the MGMT promoter region associated with reduced MGMT expression in primary colorectal cancers. Mol Carcinog 1999; 24: 90-98.
    • (1999) Mol. Carcinog. , vol.24 , pp. 90-98
    • Herfarth, K.K.1    Brent, T.P.2    Danam, R.P.3    Remack, J.S.4    Kodner, I.J.5    Wells Jr., S.A.6
  • 87
    • 0031906084 scopus 로고    scopus 로고
    • The role of DNA mismatch repair in drug resistance
    • Fink D, Aebi S, Howell SB. The role of DNA mismatch repair in drug resistance. Clin Cancer Res 1998; 4: 1-6.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 1-6
    • Fink, D.1    Aebi, S.2    Howell, S.B.3
  • 88
    • 0029042130 scopus 로고
    • Identification of mismatch repair genes and their role in the development of cancer
    • Fishel R, Kolodner RD. Identification of mismatch repair genes and their role in the development of cancer. Curr Opin Genet Dev 1995; 5: 382-395.
    • (1995) Curr. Opin. Genet. Dev. , vol.5 , pp. 382-395
    • Fishel, R.1    Kolodner, R.D.2
  • 89
    • 0030741503 scopus 로고    scopus 로고
    • hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents
    • Brown R, Hirst GL, Gallagher WM, McIlwrath AJ, Margison GP, van der Zee AG, et al. hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents. Oncogene 1997; 15: 45-52.
    • (1997) Oncogene , vol.15 , pp. 45-52
    • Brown, R.1    Hirst, G.L.2    Gallagher, W.M.3    McIlwrath, A.J.4    Margison, G.P.5    van der Zee, A.G.6
  • 90
    • 0034326784 scopus 로고    scopus 로고
    • Reversal of drug resistance in human tumor xenografts by 2′-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter
    • Plumb JA, Strathdee G, Sludden J, Kaye SB, Brown R. Reversal of drug resistance in human tumor xenografts by 2′-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter. Cancer Res 2000; 60: 6039-6044.
    • (2000) Cancer Res. , vol.60 , pp. 6039-6044
    • Plumb, J.A.1    Strathdee, G.2    Sludden, J.3    Kaye, S.B.4    Brown, R.5
  • 91
    • 0035964610 scopus 로고    scopus 로고
    • A change in microsatellite instability caused by cisplatin-based chemotherapy of ovarian cancer
    • Watanabe Y, Koi M, Hemmi H, Hoshai H, Noda K. A change in microsatellite instability caused by cisplatin-based chemotherapy of ovarian cancer. Br J Cancer 2001; 85: 1064-1069.
    • (2001) Br. J. Cancer , vol.85 , pp. 1064-1069
    • Watanabe, Y.1    Koi, M.2    Hemmi, H.3    Hoshai, H.4    Noda, K.5
  • 93
    • 0032529467 scopus 로고    scopus 로고
    • The role of hMLH1, hMSH3, and hMSH6 defects in cisplatin and oxaliplatin resistance: Correlation with replicative bypass of platinum-DNA adducts
    • Vaisman A, Varchenko M, Umar A, Kunkel TA, Risinger JI, Barrett JC, et al. The role of hMLH1, hMSH3, and hMSH6 defects in cisplatin and oxaliplatin resistance: correlation with replicative bypass of platinum-DNA adducts. Cancer Res 1998; 58: 3579-3585.
    • (1998) Cancer Res. , vol.58 , pp. 3579-3585
    • Vaisman, A.1    Varchenko, M.2    Umar, A.3    Kunkel, T.A.4    Risinger, J.I.5    Barrett, J.C.6
  • 94
    • 0032933747 scopus 로고    scopus 로고
    • Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes
    • Durant ST, Morris MM, Illand M, McKay HJ, McCormick C, Hirst GL, et al. Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes. Curr Biol 1999; 9: 51-54.
    • (1999) Curr. Biol. , vol.9 , pp. 51-54
    • Durant, S.T.1    Morris, M.M.2    Illand, M.3    McKay, H.J.4    McCormick, C.5    Hirst, G.L.6
  • 95
    • 0035392965 scopus 로고    scopus 로고
    • Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses
    • Meyers M, Wagner MW, Hwang HS, Kinsella TJ, Boothman DA. Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses. Cancer Res 2001; 61: 5193-5201.
    • (2001) Cancer Res. , vol.61 , pp. 5193-5201
    • Meyers, M.1    Wagner, M.W.2    Hwang, H.S.3    Kinsella, T.J.4    Boothman, D.A.5
  • 96
    • 0034895979 scopus 로고    scopus 로고
    • P53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma
    • Elsaleh H, Powell B, McCaul K, Grieu F, Grant R, Joseph D, et al. P53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma. Clin Cancer Res 2001; 7: 1343-1349.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1343-1349
    • Elsaleh, H.1    Powell, B.2    McCaul, K.3    Grieu, F.4    Grant, R.5    Joseph, D.6
  • 97
    • 13644268128 scopus 로고    scopus 로고
    • Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity
    • Banerjea A, Ahmed S, Hands RE, Huang F, Han X, Shaw PM, et al. Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity. Mol Cancer 2004; 3: 21.
    • (2004) Mol. Cancer , vol.3 , pp. 21
    • Banerjea, A.1    Ahmed, S.2    Hands, R.E.3    Huang, F.4    Han, X.5    Shaw, P.M.6
  • 98
    • 4644286993 scopus 로고    scopus 로고
    • Biological features of sporadic colorectal carcinoma with high-frequency microsatellite instability: Special reference to tumor proliferation and apoptosis
    • Mori S, Ogata Y, Shirouzu K. Biological features of sporadic colorectal carcinoma with high-frequency microsatellite instability: special reference to tumor proliferation and apoptosis. Int J Clin Oncol 2004; 9: 322-329.
    • (2004) Int. J. Clin. Oncol. , vol.9 , pp. 322-329
    • Mori, S.1    Ogata, Y.2    Shirouzu, K.3
  • 100
    • 0029812676 scopus 로고    scopus 로고
    • Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line
    • Drummond JT, Anthoney A, Brown R, Modrich P. Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line. J Biol Chem 1996; 271 19 645-19 648.
    • (1996) J. Biol. Chem. , vol.271 , pp. 19645-19648
    • Drummond, J.T.1    Anthoney, A.2    Brown, R.3    Modrich, P.4
  • 101
    • 0031908505 scopus 로고    scopus 로고
    • The effect of different chemotherapeutic agents on the enrichment of DNA mismatch repair-deficient tumour cells
    • Fink D, Nebel S, Norris PS, Aebi S, Kim HK, Haas M, et al. The effect of different chemotherapeutic agents on the enrichment of DNA mismatch repair-deficient tumour cells. Br J Cancer 1998; 77 703-708.
    • (1998) Br. J. Cancer , vol.77 , pp. 703-708
    • Fink, D.1    Nebel, S.2    Norris, P.S.3    Aebi, S.4    Kim, H.K.5    Haas, M.6
  • 102
    • 0035418619 scopus 로고    scopus 로고
    • The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells
    • Jacob S, Aguado M, Fallik D, Praz F. The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells. Cancer Res 2001; 61: 6555-6562.
    • (2001) Cancer Res. , vol.61 , pp. 6555-6562
    • Jacob, S.1    Aguado, M.2    Fallik, D.3    Praz, F.4
  • 104
    • 0033973828 scopus 로고    scopus 로고
    • Sensitivity to CPT-11 of xenografted human colorectal cancers as a function of microsatellite instability and p53 status
    • Bras-Goncalves RA, Rosty C, Laurent-Puig P, Soulie P, Dutrillaux B, Poupon MF. Sensitivity to CPT-11 of xenografted human colorectal cancers as a function of microsatellite instability and p53 status. Br J Cancer 2000; 82: 913-923.
    • (2000) Br. J. Cancer , vol.82 , pp. 913-923
    • Bras-Goncalves, R.A.1    Rosty, C.2    Laurent-Puig, P.3    Soulie, P.4    Dutrillaux, B.5    Poupon, M.F.6
  • 105
    • 0141731323 scopus 로고    scopus 로고
    • Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer
    • Fallik D, Borrini F, Boige V, Viguier J, Jacob S, Miquel C, et al. Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer. Cancer Res 2003; 63: 5738-5744.
    • (2003) Cancer Res. , vol.63 , pp. 5738-5744
    • Fallik, D.1    Borrini, F.2    Boige, V.3    Viguier, J.4    Jacob, S.5    Miquel, C.6
  • 107
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997; 88: 323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 109
    • 4143053880 scopus 로고    scopus 로고
    • Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation
    • Feng J, Tamaskovic R, Yang Z, Brazil DP, Merlo A, Hess D, et al. Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation. J Biol Chem 2004; 279: 35 510-35 517.
    • (2004) J. Biol. Chem. , vol.279 , pp. 35510-35517
    • Feng, J.1    Tamaskovic, R.2    Yang, Z.3    Brazil, D.P.4    Merlo, A.5    Hess, D.6
  • 110
    • 0034039040 scopus 로고    scopus 로고
    • Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress
    • Ljungman M. Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress. Neoplasia 2000; 2: 208-225.
    • (2000) Neoplasia , vol.2 , pp. 208-225
    • Ljungman, M.1
  • 111
    • 0034738420 scopus 로고    scopus 로고
    • p21(WAF1/Cip1): More than a break to the cell cycle?
    • Dotto GP. p21(WAF1/Cip1): more than a break to the cell cycle? Biochim Biophys Acta 2000; 1471: M43-M56.
    • (2000) Biochim. Biophys. Acta , vol.1471
    • Dotto, G.P.1
  • 112
    • 0031946364 scopus 로고    scopus 로고
    • Tumor suppressor p53 can participate in transcriptional induction of the GADD45 promoter in the absence of direct DNA binding
    • Zhan Q, Chen IT, Antinore MJ, Fornace AJ Jr. Tumor suppressor p53 can participate in transcriptional induction of the GADD45 promoter in the absence of direct DNA binding. Mol Cell Biol 1998; 18: 2768-2778.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 2768-2778
    • Zhan, Q.1    Chen, I.T.2    Antinore, M.J.3    Fornace Jr., A.J.4
  • 113
    • 0028335717 scopus 로고
    • Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
    • Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 1994; 9: 1799-1805.
    • (1994) Oncogene , vol.9 , pp. 1799-1805
    • Miyashita, T.1    Krajewski, S.2    Krajewska, M.3    Wang, H.G.4    Lin, H.K.5    Liebermann, D.A.6
  • 114
    • 0033748796 scopus 로고    scopus 로고
    • p53 dependence of Fas induction and acute apoptosis in response to 5-fluorouracil-leucovorin in human colon carcinoma cell lines
    • Petak I, Tillman DM, Houghton JA. p53 dependence of Fas induction and acute apoptosis in response to 5-fluorouracil-leucovorin in human colon carcinoma cell lines. Clin Cancer Res 2000; 6: 4432-4441.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 4432-4441
    • Petak, I.1    Tillman, D.M.2    Houghton, J.A.3
  • 115
    • 0035206383 scopus 로고    scopus 로고
    • Mechanisms of p53-dependent apoptosis
    • Schuler M, Green DR. Mechanisms of p53-dependent apoptosis. Biochem Soc Trans 2001; 29: 684-688.
    • (2001) Biochem. Soc. Trans. , vol.29 , pp. 684-688
    • Schuler, M.1    Green, D.R.2
  • 117
    • 0034703742 scopus 로고    scopus 로고
    • p53: Death star
    • Vousden KH. p53: death star. Cell 2000; 103: 691-694.
    • (2000) Cell , vol.103 , pp. 691-694
    • Vousden, K.H.1
  • 118
    • 0033826530 scopus 로고    scopus 로고
    • Genetic analysis of chemoresistance in primary murine lymphomas
    • Schmitt CA, Rosenthal CT, Lowe SW. Genetic analysis of chemoresistance in primary murine lymphomas. Nature Med 2000; 6 1029-1035.
    • (2000) Nature Med. , vol.6 , pp. 1029-1035
    • Schmitt, C.A.1    Rosenthal, C.T.2    Lowe, S.W.3
  • 119
    • 0034664733 scopus 로고    scopus 로고
    • p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
    • Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, et al. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 2000; 102: 849-862.
    • (2000) Cell , vol.102 , pp. 849-862
    • Oda, K.1    Arakawa, H.2    Tanaka, T.3    Matsuda, K.4    Tanikawa, C.5    Mori, T.6
  • 121
    • 0032701521 scopus 로고    scopus 로고
    • Disruption of p53 in human cancer cells alters the responses to therapeutic agents
    • Bunz F, Hwang PM, Torrance C, Waldman T, Zhang Y, Dillehay L, et al. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest 1999; 104: 263-269.
    • (1999) J. Clin. Invest. , vol.104 , pp. 263-269
    • Bunz, F.1    Hwang, P.M.2    Torrance, C.3    Waldman, T.4    Zhang, Y.5    Dillehay, L.6
  • 122
    • 0036466874 scopus 로고    scopus 로고
    • P53 overexpression predicts poor chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV colorectal cancers after palliative bowel resection
    • Liang JT, Huang KC, Cheng YM, Hsu HC, Cheng AL, Hsu CH, et al. P53 overexpression predicts poor chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV colorectal cancers after palliative bowel resection. Int J Cancer 2002; 97 451-457.
    • (2002) Int. J. Cancer , vol.97 , pp. 451-457
    • Liang, J.T.1    Huang, K.C.2    Cheng, Y.M.3    Hsu, H.C.4    Cheng, A.L.5    Hsu, C.H.6
  • 123
    • 0032521205 scopus 로고    scopus 로고
    • Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: A Southwest Oncology Group study
    • Ahnen DJ, Feigl P, Quan G, Fenoglio-Preiser C, Lovato LC, Bunn PA Jr, et al. Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study. Cancer Res 1998; 58: 1149-1158.
    • (1998) Cancer Res. , vol.58 , pp. 1149-1158
    • Ahnen, D.J.1    Feigl, P.2    Quan, G.3    Fenoglio-Preiser, C.4    Lovato, L.C.5    Bunn Jr., P.A.6
  • 124
    • 0033975032 scopus 로고    scopus 로고
    • Thymidylate synthase and p53 primary tumour expression as predictive factors for advanced colorectal cancer patients
    • Paradiso A, Simone G, Petroni S, Leone B, Vallejo C, Lacava J, et al. Thymidylate synthase and p53 primary tumour expression as predictive factors for advanced colorectal cancer patients. Br J Cancer 2000; 82: 560-567.
    • (2000) Br. J. Cancer , vol.82 , pp. 560-567
    • Paradiso, A.1    Simone, G.2    Petroni, S.3    Leone, B.4    Vallejo, C.5    Lacava, J.6
  • 125
    • 0030058617 scopus 로고    scopus 로고
    • The p53 gene in breast cancer: Prognostic value of complementary DNA sequencing versus immunohistochemistry
    • Sjogren S, Inganas M, Norberg T, Lindgren A, Nordgren H, Holmberg L, et al. The p53 gene in breast cancer: prognostic value of complementary DNA sequencing versus immunohistochemistry. J Natl Cancer Inst 1996; 88: 173-182.
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 173-182
    • Sjogren, S.1    Inganas, M.2    Norberg, T.3    Lindgren, A.4    Nordgren, H.5    Holmberg, L.6
  • 126
    • 0034122591 scopus 로고    scopus 로고
    • Gain-of-function mutations in the tumor suppressor gene p53
    • van Oijen MG, Slootweg PJ. Gain-of-function mutations in the tumor suppressor gene p53. Clin Cancer Res 2000; 6: 2138-2145.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2138-2145
    • van Oijen, M.G.1    Slootweg, P.J.2
  • 127
    • 0028171454 scopus 로고
    • p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents
    • Fan S, el-Deiry WS, Bae I, Freeman J, Jondle D, Bhatia K, et al. p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. Cancer Res 1994; 54 5824-5830.
    • (1994) Cancer Res. , vol.54 , pp. 5824-5830
    • Fan, S.1    el-Deiry, W.S.2    Bae, I.3    Freeman, J.4    Jondle, D.5    Bhatia, K.6
  • 128
    • 8944263468 scopus 로고    scopus 로고
    • Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems
    • Perego P, Giarola M, Righetti SC, Supino R, Caserini C, Delia D, et al. Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems. Cancer Res 1996; 56: 556-562.
    • (1996) Cancer Res. , vol.56 , pp. 556-562
    • Perego, P.1    Giarola, M.2    Righetti, S.C.3    Supino, R.4    Caserini, C.5    Delia, D.6
  • 129
    • 0031014097 scopus 로고    scopus 로고
    • Identification of p53 genetic suppressor elements which confer resistance to cisplatin
    • Gallagher WM, Cairney M, Schott B, Roninson IB, Brown R. Identification of p53 genetic suppressor elements which confer resistance to cisplatin. Oncogene 1997; 14: 185-193.
    • (1997) Oncogene , vol.14 , pp. 185-193
    • Gallagher, W.M.1    Cairney, M.2    Schott, B.3    Roninson, I.B.4    Brown, R.5
  • 130
    • 0028901034 scopus 로고
    • Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline
    • Fan S, Smith ML, Rivet DJ 2nd, Duba D, Zhan Q, Kohn KW, et al. Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline. Cancer Res 1995; 55: 1649-1654.
    • (1995) Cancer Res. , vol.55 , pp. 1649-1654
    • Fan, S.1    Smith, M.L.2    Rivet II, D.J.3    Duba, D.4    Zhan, Q.5    Kohn, K.W.6
  • 131
    • 0030021996 scopus 로고    scopus 로고
    • Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents
    • Hawkins DS, Demers GW, Galloway DA. Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents. Cancer Res 1996; 56: 892-898.
    • (1996) Cancer Res. , vol.56 , pp. 892-898
    • Hawkins, D.S.1    Demers, G.W.2    Galloway, D.A.3
  • 132
    • 0030865104 scopus 로고    scopus 로고
    • Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents
    • O'Connor PM, Jackman J, Bae I, Myers TG, Fan S, Mutoh M, et al. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res 1997; 57: 4285-4300.
    • (1997) Cancer Res. , vol.57 , pp. 4285-4300
    • O'Connor, P.M.1    Jackman, J.2    Bae, I.3    Myers, T.G.4    Fan, S.5    Mutoh, M.6
  • 133
    • 0031660241 scopus 로고    scopus 로고
    • Immunophenotype of ovarian cancer as predictor of clinical outcome: Evaluation at primary surgery and second-look procedure
    • Goff BA, Ries JA, Els LP, Coltrera MD, Gown AM. Immunophenotype of ovarian cancer as predictor of clinical outcome: evaluation at primary surgery and second-look procedure. Gynecol Oncol 1998; 70: 378-385.
    • (1998) Gynecol. Oncol. , vol.70 , pp. 378-385
    • Goff, B.A.1    Ries, J.A.2    Els, L.P.3    Coltrera, M.D.4    Gown, A.M.5
  • 134
    • 13344249778 scopus 로고    scopus 로고
    • A comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinoma
    • Righetti SC, Della Torre G, Pilotti S, Menard S, Ottone F, Colnaghi MI, et al. A comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinoma. Cancer Res 1996; 56: 689-693.
    • (1996) Cancer Res. , vol.56 , pp. 689-693
    • Righetti, S.C.1    Della Torre, G.2    Pilotti, S.3    Menard, S.4    Ottone, F.5    Colnaghi, M.I.6
  • 135
    • 0032077390 scopus 로고    scopus 로고
    • Expression of the p53 tumour suppressor gene as a prognostic marker in platinum-treated patients with ovarian cancer
    • Marx D, Meden H, Ziemek T, Lenthe T, Kuhn W, Schauer A. Expression of the p53 tumour suppressor gene as a prognostic marker in platinum-treated patients with ovarian cancer. Eur J Cancer 1998; 34: 845-850.
    • (1998) Eur. J. Cancer , vol.34 , pp. 845-850
    • Marx, D.1    Meden, H.2    Ziemek, T.3    Lenthe, T.4    Kuhn, W.5    Schauer, A.6
  • 136
    • 0033926677 scopus 로고    scopus 로고
    • Immunohistochemical analysis of drug resistance-associated proteins in ovarian carcinomas
    • Mayr D, Pannekamp U, Baretton GB, Gropp M, Meier W, Flens MJ, et al. Immunohistochemical analysis of drug resistance-associated proteins in ovarian carcinomas. Pathol Res Pract 2000; 196: 469-475.
    • (2000) Pathol. Res. Pract. , vol.196 , pp. 469-475
    • Mayr, D.1    Pannekamp, U.2    Baretton, G.B.3    Gropp, M.4    Meier, W.5    Flens, M.J.6
  • 137
    • 4444375998 scopus 로고    scopus 로고
    • Enhanced oxaliplatin-induced apoptosis following antisense Bcl-xl down-regulation is p53 and Bax dependent: Genetic evidence for specificity of the antisense effect
    • Hayward RL, Macpherson JS, Cummings J, Monia BP, Smyth JF, Jodrell DI. Enhanced oxaliplatin-induced apoptosis following antisense Bcl-xl down-regulation is p53 and Bax dependent: genetic evidence for specificity of the antisense effect. Mol Cancer Ther 2004; 3: 169-178.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 169-178
    • Hayward, R.L.1    Macpherson, J.S.2    Cummings, J.3    Monia, B.P.4    Smyth, J.F.5    Jodrell, D.I.6
  • 138
    • 3843128735 scopus 로고    scopus 로고
    • The role of p53 in the chemotherapeutic responses to cisplatin, doxorubicin and 5-fluorouracil treatment
    • Dart DA, Picksley SM, Cooper PA, Double JA, Bibby MC. The role of p53 in the chemotherapeutic responses to cisplatin, doxorubicin and 5-fluorouracil treatment. Int J Oncol 2004; 24: 115-125.
    • (2004) Int. J. Oncol. , vol.24 , pp. 115-125
    • Dart, D.A.1    Picksley, S.M.2    Cooper, P.A.3    Double, J.A.4    Bibby, M.C.5
  • 139
    • 0032824012 scopus 로고    scopus 로고
    • p53 gene status and chemosensitivity of childhood acute lymphoblastic leukemia cells to adriamycin
    • Lam V, McPherson JP, Salmena L, Lees J, Chu W, Sexsmith E, et al. p53 gene status and chemosensitivity of childhood acute lymphoblastic leukemia cells to adriamycin. Leuk Res 1999; 23 871-880.
    • (1999) Leuk. Res. , vol.23 , pp. 871-880
    • Lam, V.1    McPherson, J.P.2    Salmena, L.3    Lees, J.4    Chu, W.5    Sexsmith, E.6
  • 140
    • 0035866772 scopus 로고    scopus 로고
    • Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer
    • Geisler S, Lonning PE, Aas T, Johnsen H, Fluge O, Haugen DF, et al. Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer. Cancer Res 2001; 61: 2505-2512.
    • (2001) Cancer Res. , vol.61 , pp. 2505-2512
    • Geisler, S.1    Lonning, P.E.2    Aas, T.3    Johnsen, H.4    Fluge, O.5    Haugen, D.F.6
  • 141
    • 0346023951 scopus 로고    scopus 로고
    • Anticancer drug response and expression of molecular markers in early-passage xenotransplanted colon carcinomas
    • Fichtner I, Slisow W, Gill J, Becker M, Elbe B, Hillebrand T, et al. Anticancer drug response and expression of molecular markers in early-passage xenotransplanted colon carcinomas. Eur J Cancer 2004; 40: 298-307.
    • (2004) Eur. J. Cancer , vol.40 , pp. 298-307
    • Fichtner, I.1    Slisow, W.2    Gill, J.3    Becker, M.4    Elbe, B.5    Hillebrand, T.6
  • 142
    • 2442449490 scopus 로고    scopus 로고
    • Cellular parameters predictive of the clinical response of colorectal cancers to irinotecan. A preliminary study
    • Pavillard V, Charasson V, Laroche-Clary A, Soubeyran I, Robert J. Cellular parameters predictive of the clinical response of colorectal cancers to irinotecan. A preliminary study. Anticancer Res 2004; 24: 579-585.
    • (2004) Anticancer Res. , vol.24 , pp. 579-585
    • Pavillard, V.1    Charasson, V.2    Laroche-Clary, A.3    Soubeyran, I.4    Robert, J.5
  • 143
    • 0036024593 scopus 로고    scopus 로고
    • Mutations of TP53 do not correlate with the sensitivity to paclitaxel - A study using 27 gynaecological cancer cell lines
    • Rantanen V, Engblom P, Raitanen M, Hietanen S, Haarala M, Grenman S, et al. Mutations of TP53 do not correlate with the sensitivity to paclitaxel - a study using 27 gynaecological cancer cell lines. Eur J Cancer 2002; 38: 1783-1791.
    • (2002) Eur. J. Cancer , vol.38 , pp. 1783-1791
    • Rantanen, V.1    Engblom, P.2    Raitanen, M.3    Hietanen, S.4    Haarala, M.5    Grenman, S.6
  • 144
    • 0030026934 scopus 로고    scopus 로고
    • Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis
    • Wahl AF, Donaldson KL, Fairchild C, Lee FY, Foster SA, Demers GW, et al. Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis. Nature Med 1996; 2: 72-79.
    • (1996) Nature Med. , vol.2 , pp. 72-79
    • Wahl, A.F.1    Donaldson, K.L.2    Fairchild, C.3    Lee, F.Y.4    Foster, S.A.5    Demers, G.W.6
  • 145
    • 0036870714 scopus 로고    scopus 로고
    • Reduced expression of p53 and p21WAF1/CIP1 sensitizes human breast cancer cells to paclitaxel and its combination with 5-fluorouracil
    • Johnson KR, Fan W. Reduced expression of p53 and p21WAF1/CIP1 sensitizes human breast cancer cells to paclitaxel and its combination with 5-fluorouracil. Anticancer Res 2002; 22: 3197-3204.
    • (2002) Anticancer Res. , vol.22 , pp. 3197-3204
    • Johnson, K.R.1    Fan, W.2
  • 146
    • 0034551724 scopus 로고    scopus 로고
    • p53 gene status and response to platinum/paclitaxel-based chemotherapy in advanced ovarian carcinoma
    • Lavarino C, Pilotti S, Oggionni M, Gatti L, Perego P, Bresciani G, et al. p53 gene status and response to platinum/paclitaxel-based chemotherapy in advanced ovarian carcinoma. J Clin Oncol 2000; 18: 3936-3945.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 3936-3945
    • Lavarino, C.1    Pilotti, S.2    Oggionni, M.3    Gatti, L.4    Perego, P.5    Bresciani, G.6
  • 147
    • 0034495749 scopus 로고    scopus 로고
    • p53 status is neither a predictive nor a prognostic variable in patients with advanced ovarian cancer treated with a paclitaxel-based regimen
    • Gadducci A, Cianci C, Cosio S, Carnino F, Fanucchi A, Buttitta F, et al. p53 status is neither a predictive nor a prognostic variable in patients with advanced ovarian cancer treated with a paclitaxel-based regimen. Anticancer Res 2000; 20: 4793-4799.
    • (2000) Anticancer Res. , vol.20 , pp. 4793-4799
    • Gadducci, A.1    Cianci, C.2    Cosio, S.3    Carnino, F.4    Fanucchi, A.5    Buttitta, F.6
  • 149
    • 0034655991 scopus 로고    scopus 로고
    • BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
    • Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev 2000; 14: 927-939.
    • (2000) Genes Dev. , vol.14 , pp. 927-939
    • Wang, Y.1    Cortez, D.2    Yazdi, P.3    Neff, N.4    Elledge, S.J.5    Qin, J.6
  • 150
  • 151
    • 0035032649 scopus 로고    scopus 로고
    • Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation
    • Xu B, Kim S, Kastan MB. Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol Cell Biol 2001; 21: 3445-3450.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 3445-3450
    • Xu, B.1    Kim, S.2    Kastan, M.B.3
  • 152
    • 0035959804 scopus 로고    scopus 로고
    • BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents
    • Mullan PB, Quinn JE, Gilmore PM, McWilliams S, Andrews H, Gervin C, et al. BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents. Oncogene 2001; 20: 6123-6131.
    • (2001) Oncogene , vol.20 , pp. 6123-6131
    • Mullan, P.B.1    Quinn, J.E.2    Gilmore, P.M.3    McWilliams, S.4    Andrews, H.5    Gervin, C.6
  • 153
    • 0033668758 scopus 로고    scopus 로고
    • Uncovering functionally relevant signaling pathways using microarray-based expression profiling
    • Harkin DP. Uncovering functionally relevant signaling pathways using microarray-based expression profiling. Oncologist 2000; 5: 501-507.
    • (2000) Oncologist , vol.5 , pp. 501-507
    • Harkin, D.P.1
  • 155
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407: 770-776.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 156
    • 0032409781 scopus 로고    scopus 로고
    • Bcl-2 family proteins
    • Reed JC. Bcl-2 family proteins. Oncogene 1998; 17 3225-3236.
    • (1998) Oncogene , vol.17 , pp. 3225-3236
    • Reed, J.C.1
  • 157
    • 0026781986 scopus 로고
    • bcl-2 gene transfer increases relative resistance of S49.1 and WEH17.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs
    • Miyashita T, Reed JC. bcl-2 gene transfer increases relative resistance of S49.1 and WEH17.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. Cancer Res 1992; 52: 5407-5411.
    • (1992) Cancer Res. , vol.52 , pp. 5407-5411
    • Miyashita, T.1    Reed, J.C.2
  • 158
    • 0029157380 scopus 로고
    • Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells
    • Teixeira C, Reed JC, Pratt MA. Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res 1995; 55: 3902-3907.
    • (1995) Cancer Res. , vol.55 , pp. 3902-3907
    • Teixeira, C.1    Reed, J.C.2    Pratt, M.A.3
  • 160
    • 1342332363 scopus 로고    scopus 로고
    • Antisense to apoptosis inhibitors facilitates chemotherapy and TRAIL-induced death signaling
    • Zangemeister-Wittke U. Antisense to apoptosis inhibitors facilitates chemotherapy and TRAIL-induced death signaling. Ann N Y Acad Sci 2003; 1002: 90-94.
    • (2003) Ann. N Y Acad. Sci. , vol.1002 , pp. 90-94
    • Zangemeister-Wittke, U.1
  • 161
    • 0034602188 scopus 로고    scopus 로고
    • Role of BAX in the apoptotic response to anticancer agents
    • Zhang L, Yu J, Park BH, Kinzler KW, Vogelstein B. Role of BAX in the apoptotic response to anticancer agents. Science 2000; 290: 989-992.
    • (2000) Science , vol.290 , pp. 989-992
    • Zhang, L.1    Yu, J.2    Park, B.H.3    Kinzler, K.W.4    Vogelstein, B.5
  • 162
    • 0027164144 scopus 로고
    • High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy
    • Campos L, Rouault JP, Sabido O, Oriol P, Roubi N, Vasselon C, et al. High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy. Blood 1993; 81: 3091-3096.
    • (1993) Blood , vol.81 , pp. 3091-3096
    • Campos, L.1    Rouault, J.P.2    Sabido, O.3    Oriol, P.4    Roubi, N.5    Vasselon, C.6
  • 163
    • 0031755585 scopus 로고    scopus 로고
    • bcl-2 but not p53 expression is associated with resistance to chemotherapy in advanced breast cancer
    • Bonetti A, Zaninelli M, Leone R, Cetto GL, Pelosi G, Biolo S, et al. bcl-2 but not p53 expression is associated with resistance to chemotherapy in advanced breast cancer. Clin Cancer Res 1998; 4: 2331-2336.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 2331-2336
    • Bonetti, A.1    Zaninelli, M.2    Leone, R.3    Cetto, G.L.4    Pelosi, G.5    Biolo, S.6
  • 164
    • 0030029443 scopus 로고    scopus 로고
    • Prognostic significance of bcl-2 protein expression in aggressive non-Hodgkin's lymphoma
    • Groupe d'Etude des Lymphomes de l'Adulte (GELA)
    • Hermine O, Haioun C, Lepage E, d'Agay MF, Briere J, Lavignac C, et al. Prognostic significance of bcl-2 protein expression in aggressive non-Hodgkin's lymphoma. Groupe d'Etude des Lymphomes de l'Adulte (GELA). Blood 1996; 87: 265-272.
    • (1996) Blood , vol.87 , pp. 265-272
    • Hermine, O.1    Haioun, C.2    Lepage, E.3    d'Agay, M.F.4    Briere, J.5    Lavignac, C.6
  • 166
    • 0033926876 scopus 로고    scopus 로고
    • p53 but not bcl-2 immunostaining is predictive of poor clinical complete response to primary chemotherapy in breast cancer patients
    • Bottini A, Berruti A, Bersiga A, Brizzi MP, Brunelli A, Gorzegno G, et al. p53 but not bcl-2 immunostaining is predictive of poor clinical complete response to primary chemotherapy in breast cancer patients. Clin Cancer Res 2000; 6: 2751-2758.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2751-2758
    • Bottini, A.1    Berruti, A.2    Bersiga, A.3    Brizzi, M.P.4    Brunelli, A.5    Gorzegno, G.6
  • 167
    • 0036300989 scopus 로고    scopus 로고
    • The predictive value of bcl-2, bax, bcl-xL, bag-1, fas, and fasL for chemotherapy response in advanced breast cancer
    • Sjostrom J, Blomqvist C, von Boguslawski K, Bengtsson NO, Mjaaland I, Malmstrom P, et al. The predictive value of bcl-2, bax, bcl-xL, bag-1, fas, and fasL for chemotherapy response in advanced breast cancer. Clin Cancer Res 2002; 8: 811-816.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 811-816
    • Sjostrom, J.1    Blomqvist, C.2    von Boguslawski, K.3    Bengtsson, N.O.4    Mjaaland, I.5    Malmstrom, P.6
  • 168
    • 0029035891 scopus 로고
    • Bcl-2 protein: A prognostic factor inversely correlated to p53 in non-small-cell lung cancer
    • Fontanini G, Vignati S, Bigini D, Mussi A, Lucchi M, Angeletti CA, et al. Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer. Br J Cancer 1995; 71: 1003-1007.
    • (1995) Br. J. Cancer , vol.71 , pp. 1003-1007
    • Fontanini, G.1    Vignati, S.2    Bigini, D.3    Mussi, A.4    Lucchi, M.5    Angeletti, C.A.6
  • 169
    • 0027944957 scopus 로고
    • Bcl-2 protein expression and long-term survival in breast cancer
    • Joensuu H, Pylkkanen L, Toikkanen S. Bcl-2 protein expression and long-term survival in breast cancer. Am J Pathol 1994; 145 1191-1198.
    • (1994) Am. J. Pathol. , vol.145 , pp. 1191-1198
    • Joensuu, H.1    Pylkkanen, L.2    Toikkanen, S.3
  • 171
    • 0034901006 scopus 로고    scopus 로고
    • Can expression of apoptosis genes, bcl-2 and bax, predict survival and responsiveness to chemotherapy in node-negative breast cancer patients?
    • Kymionis GD, Dimitrakakis CE, Konstadoulakis MM, Arzimanoglou I, Leandros E, Chalkiadakis G, et al. Can expression of apoptosis genes, bcl-2 and bax, predict survival and responsiveness to chemotherapy in node-negative breast cancer patients? J Surg Res 2001; 99: 161-168.
    • (2001) J. Surg. Res. , vol.99 , pp. 161-168
    • Kymionis, G.D.1    Dimitrakakis, C.E.2    Konstadoulakis, M.M.3    Arzimanoglou, I.4    Leandros, E.5    Chalkiadakis, G.6
  • 172
    • 0029045784 scopus 로고
    • Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma
    • Krajewski S, Blomqvist C, Franssila K, Krajewska M, Wasenius VM, Niskanen E, et al. Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res 1995; 55: 4471-4478.
    • (1995) Cancer Res. , vol.55 , pp. 4471-4478
    • Krajewski, S.1    Blomqvist, C.2    Franssila, K.3    Krajewska, M.4    Wasenius, V.M.5    Niskanen, E.6
  • 173
    • 0035793799 scopus 로고    scopus 로고
    • Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer
    • Paradiso A, Simone G, Lena MD, Leone B, Vallejo C, Lacava J, et al. Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer. Br J Cancer 12001; 84: 651-658.
    • (2001) Br. J. Cancer , vol.84 , pp. 651-658
    • Paradiso, A.1    Simone, G.2    Lena, M.D.3    Leone, B.4    Vallejo, C.5    Lacava, J.6
  • 174
    • 3042570458 scopus 로고    scopus 로고
    • Oblimersen sodium (Genasense bcl-2 antisense oligonucleotide): A rational therapeutic to enhance apoptosis in therapy of lung cancer
    • Herbst RS, Frankel SR. Oblimersen sodium (Genasense bcl-2 antisense oligonucleotide): a rational therapeutic to enhance apoptosis in therapy of lung cancer. Clin Cancer Res 2004; 10: 4245s-4248s.
    • (2004) Clin. Cancer Res. , vol.10
    • Herbst, R.S.1    Frankel, S.R.2
  • 175
    • 0033396491 scopus 로고    scopus 로고
    • Fas ligand-induced apoptosis
    • Nagata S. Fas ligand-induced apoptosis. Annu Rev Genet 1999; 33: 29-55.
    • (1999) Annu. Rev. Genet. , vol.33 , pp. 29-55
    • Nagata, S.1
  • 176
    • 2542496862 scopus 로고    scopus 로고
    • The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites
    • Longley DB, Allen WL, McDermott U, Wilson TR, Latif T, Boyer J, et al. The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites. Clin Cancer Res 2004; 10: 3562-3571.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3562-3571
    • Longley, D.B.1    Allen, W.L.2    McDermott, U.3    Wilson, T.R.4    Latif, T.5    Boyer, J.6
  • 177
    • 12144260230 scopus 로고    scopus 로고
    • Synergistic antitumor activity of TRAIL combined with chemotherapeutic agents in A549 cell lines in vitro and in vivo
    • Fan QL, Zou WY, Song LH, Wei W. Synergistic antitumor activity of TRAIL combined with chemotherapeutic agents in A549 cell lines in vitro and in vivo. Cancer Chemother Pharmacol 2004; 55: 189-196.
    • (2004) Cancer Chemother. Pharmacol. , vol.55 , pp. 189-196
    • Fan, Q.L.1    Zou, W.Y.2    Song, L.H.3    Wei, W.4
  • 178
    • 3042739342 scopus 로고    scopus 로고
    • TRAIL and chemotherapeutic drugs in cancer therapy
    • Wu XX, Ogawa O, Kakehi Y. TRAIL and chemotherapeutic drugs in cancer therapy. Vitam Horm 2004; 67: 365-383.
    • (2004) Vitam. Horm. , vol.67 , pp. 365-383
    • Wu, X.X.1    Ogawa, O.2    Kakehi, Y.3
  • 179
    • 0036153928 scopus 로고    scopus 로고
    • Fas receptor-mediated apoptosis: A clinical application?
    • Timmer T, de Vries EG, de Jong S. Fas receptor-mediated apoptosis: a clinical application? J Pathol 2002; 196: 125-134.
    • (2002) J. Pathol. , vol.196 , pp. 125-134
    • Timmer, T.1    de Vries, E.G.2    de Jong, S.3
  • 181
    • 0036598992 scopus 로고    scopus 로고
    • Targeting death and decoy receptors of the tumour-necrosis factor superfamily
    • Ashkenazi A. Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nature Rev Cancer 2002; 2 420-430.
    • (2002) Nature Rev. Cancer , vol.2 , pp. 420-430
    • Ashkenazi, A.1
  • 182
    • 0035104753 scopus 로고    scopus 로고
    • 5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients
    • Backus HH, Dukers DF, van Groeningen CJ, Vos W, Bloemena E, Wouters D, et al. 5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients. Ann Oncol 2001; 12: 209-216.
    • (2001) Ann. Oncol. , vol.12 , pp. 209-216
    • Backus, H.H.1    Dukers, D.F.2    van Groeningen, C.J.3    Vos, W.4    Bloemena, E.5    Wouters, D.6
  • 186
    • 0032523931 scopus 로고    scopus 로고
    • Up-regulation of Fas (APO-1/CD95) ligand and down-regulation of Fas expression in human esophageal cancer
    • Gratas C, Tohma Y, Barnas C, Taniere P, Hainaut P, Ohgaki H. Up-regulation of Fas (APO-1/CD95) ligand and down-regulation of Fas expression in human esophageal cancer. Cancer Res 1998; 58: 2057-2062.
    • (1998) Cancer Res. , vol.58 , pp. 2057-2062
    • Gratas, C.1    Tohma, Y.2    Barnas, C.3    Taniere, P.4    Hainaut, P.5    Ohgaki, H.6
  • 187
    • 0032777209 scopus 로고    scopus 로고
    • Resistance to Fas (APO-1/CD95)-mediated apoptosis and expression of Fas ligand in esophageal cancer: The Fas counter-attack
    • O'Connell J, Bennett MW, O'Sullivan GC, Collins JK, Shanahan F. Resistance to Fas (APO-1/CD95)-mediated apoptosis and expression of Fas ligand in esophageal cancer: the Fas counter-attack. Dis Esophagus 1999; 12: 83-89.
    • (1999) Dis. Esophagus , vol.12 , pp. 83-89
    • O'Connell, J.1    Bennett, M.W.2    O'Sullivan, G.C.3    Collins, J.K.4    Shanahan, F.5
  • 188
    • 12144289124 scopus 로고    scopus 로고
    • Altered expression of FAS system is related to adverse clinical outcome in stage I-II breast cancer patients treated with adjuvant anthracycline-based chemotherapy
    • Botti C, Buglioni S, Benevolo M, Giannarelli D, Papaldo P, Cognetti F, et al. Altered expression of FAS system is related to adverse clinical outcome in stage I-II breast cancer patients treated with adjuvant anthracycline-based chemotherapy. Clin Cancer Res 2004; 10: 1360-1365.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 1360-1365
    • Botti, C.1    Buglioni, S.2    Benevolo, M.3    Giannarelli, D.4    Papaldo, P.5    Cognetti, F.6
  • 189
    • 0033866913 scopus 로고    scopus 로고
    • Clinicopathologic analysis of Fas, Fas ligand, and other biomarkers in locally advanced breast carcinoma
    • Pernick NL, Biernat L, Du W, Visscher DW. Clinicopathologic analysis of Fas, Fas ligand, and other biomarkers in locally advanced breast carcinoma. Breast J 2000; 6: 233-241.
    • (2000) Breast J. , vol.6 , pp. 233-241
    • Pernick, N.L.1    Biernat, L.2    Du, W.3    Visscher, D.W.4
  • 191
    • 0037145743 scopus 로고    scopus 로고
    • DCR3 locus is a predictive marker for 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer
    • Mild G, Bachmann F, Boulay JL, Glatz K, Laffer U, Lowy A, et al. DCR3 locus is a predictive marker for 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer. Int J Cancer 2002; 102: 254-257.
    • (2002) Int. J. Cancer , vol.102 , pp. 254-257
    • Mild, G.1    Bachmann, F.2    Boulay, J.L.3    Glatz, K.4    Laffer, U.5    Lowy, A.6
  • 192
    • 0035192884 scopus 로고    scopus 로고
    • FLICE-inhibitory proteins: Regulators of death receptor-mediated apoptosis
    • Krueger A, Baumann S, Krammer PH, Kirchhoff S. FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis. Mol Cell Biol 2001; 21: 8247-8254.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 8247-8254
    • Krueger, A.1    Baumann, S.2    Krammer, P.H.3    Kirchhoff, S.4
  • 193
    • 0030810981 scopus 로고    scopus 로고
    • FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis
    • Srinivasula SM, Ahmad M, Ottili S, Bullrich F, Banks S, Wang Y, et al. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. J Biol Chem 1997; 272: 18 542-18 545.
    • (1997) J. Biol. Chem. , vol.272 , pp. 18542-18545
    • Srinivasula, S.M.1    Ahmad, M.2    Ottili, S.3    Bullrich, F.4    Banks, S.5    Wang, Y.6
  • 195
    • 0030841911 scopus 로고    scopus 로고
    • I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis
    • Hu S, Vincenz C, Ni J, Gentz R, Dixit VM. I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis. J Biol Chem 1997; 272: 17 255-17 257.
    • (1997) J. Biol. Chem. , vol.272 , pp. 17255-17257
    • Hu, S.1    Vincenz, C.2    Ni, J.3    Gentz, R.4    Dixit, V.M.5
  • 196
    • 33144488766 scopus 로고    scopus 로고
    • Increased expression of cFLIP(L) in colonic adenocarcinoma
    • Ryu BK, Lee MG, Chi SG, Kim YW, Park JH. Increased expression of cFLIP(L) in colonic adenocarcinoma. J Pathol 2001; 194: 15-19.
    • (2001) J. Pathol. , vol.194 , pp. 15-19
    • Ryu, B.K.1    Lee, M.G.2    Chi, S.G.3    Kim, Y.W.4    Park, J.H.5
  • 197
    • 2142821427 scopus 로고    scopus 로고
    • Overexpression of cellular FLICE-inhibitory protein (FLIP) in gastric adenocarcinoma
    • Zhou XD, Yu JP, Liu J, Luo HS, Chen HX, Yu HG. Overexpression of cellular FLICE-inhibitory protein (FLIP) in gastric adenocarcinoma. Clin Sci (London) 2004; 106: 397-405.
    • (2004) Clin. Sci. (London) , vol.106 , pp. 397-405
    • Zhou, X.D.1    Yu, J.P.2    Liu, J.3    Luo, H.S.4    Chen, H.X.5    Yu, H.G.6
  • 199
    • 0032403126 scopus 로고    scopus 로고
    • IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anti-cancer drugs
    • Tamm I, Wang Y, Sausville E, Scudiero, DA, Vigna N, Oltersdorf T, et al. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anti-cancer drugs. Cancer Res 1998; 58: 5315-5320.
    • (1998) Cancer Res. , vol.58 , pp. 5315-5320
    • Tamm, I.1    Wang, Y.2    Sausville, E.3    Scudiero, D.A.4    Vigna, N.5    Oltersdorf, T.6
  • 200
    • 1142263100 scopus 로고    scopus 로고
    • Survivin as a predictor of cis-diamminedichloroplatinum sensitivity in gastric cancer patients
    • Nakamura M, Tsuji N, Asanuma K, Kobayashi D, Yagihashi A, Hirata K, et al. Survivin as a predictor of cis diamminedichloroplatinum sensitivity in gastric cancer patients. Cancer Sci 2004; 95: 44-51.
    • (2004) Cancer Sci. , vol.95 , pp. 44-51
    • Nakamura, M.1    Tsuji, N.2    Asanuma, K.3    Kobayashi, D.4    Yagihashi, A.5    Hirata, K.6
  • 202
    • 0036693488 scopus 로고    scopus 로고
    • Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer
    • Zaffaroni N, Pennati M, Colella G, Perego P, Supino R, Gatti L, et al. Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer. Cell Mol Life Sci 2002; 59: 1406-1412.
    • (2002) Cell Mol. Life Sci. , vol.59 , pp. 1406-1412
    • Zaffaroni, N.1    Pennati, M.2    Colella, G.3    Perego, P.4    Supino, R.5    Gatti, L.6
  • 203
    • 0035916997 scopus 로고    scopus 로고
    • Expression of survivin in esophageal cancer: Correlation with the prognosis and response to chemotherapy
    • Kato J, Kuwabara Y, Mitani M, Shinoda N, Sato A, Toyama T, et al. Expression of survivin in esophageal cancer: correlation with the prognosis and response to chemotherapy. Int J Cancer 2001; 95: 92-95.
    • (2001) Int. J. Cancer , vol.95 , pp. 92-95
    • Kato, J.1    Kuwabara, Y.2    Mitani, M.3    Shinoda, N.4    Sato, A.5    Toyama, T.6
  • 204
    • 2542549018 scopus 로고    scopus 로고
    • High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia
    • Tamm I, Richter S, Oltersdorf D, Creutzig U, Harbott J, Scholz F, et al. High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia. Clin Cancer Res 2004; 10: 3737-3744.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3737-3744
    • Tamm, I.1    Richter, S.2    Oltersdorf, D.3    Creutzig, U.4    Harbott, J.5    Scholz, F.6
  • 205
    • 0034954219 scopus 로고    scopus 로고
    • Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients
    • Ferreira CG, van der Valk P, Span SW, Jonker JM, Postmus PE, Kruyt FA, et al. Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients. Ann Oncol 2001; 12: 799-805.
    • (2001) Ann. Oncol. , vol.12 , pp. 799-805
    • Ferreira, C.G.1    van der Valk, P.2    Span, S.W.3    Jonker, J.M.4    Postmus, P.E.5    Kruyt, F.A.6
  • 206
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature 2001; 411: 355-365.
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 208
    • 0034600849 scopus 로고    scopus 로고
    • The ErbB signaling network: Receptor heterodimerization in development and cancer
    • Olayioye MA, Neve RM, Lane HA, Hynes NE. The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J 2000; 19: 3159-3167.
    • (2000) EMBO J. , vol.19 , pp. 3159-3167
    • Olayioye, M.A.1    Neve, R.M.2    Lane, H.A.3    Hynes, N.E.4
  • 209
    • 2342492317 scopus 로고    scopus 로고
    • Review of epidermal growth factor receptor biology
    • Herbst RS. Review of epidermal growth factor receptor biology. Int J Radiat Oncol Biol Phys 2004; 59(2 Suppl): 21-26.
    • (2004) Int. J. Radiat. Oncol. Biol. Phys. , vol.59 , Issue.2 SUPPL. , pp. 21-26
    • Herbst, R.S.1
  • 210
    • 0030870295 scopus 로고    scopus 로고
    • The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells
    • Pegram MD, Finn RS, Arzoo K, Beryt M, Pietras RJ, Slamon DJ. The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells. Oncogene 1997; 15: 537-547.
    • (1997) Oncogene , vol.15 , pp. 537-547
    • Pegram, M.D.1    Finn, R.S.2    Arzoo, K.3    Beryt, M.4    Pietras, R.J.5    Slamon, D.J.6
  • 211
    • 0034597662 scopus 로고    scopus 로고
    • Enhanced drug resistance in cells coexpressing ErbB2 with EGF receptor or ErbB3
    • Chen X, Yeung TK, Wang Z. Enhanced drug resistance in cells coexpressing ErbB2 with EGF receptor or ErbB3. Biochem Biophys Res Commun 2000; 277: 757-763.
    • (2000) Biochem. Biophys. Res. Commun. , vol.277 , pp. 757-763
    • Chen, X.1    Yeung, T.K.2    Wang, Z.3
  • 212
    • 0032510679 scopus 로고    scopus 로고
    • Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases
    • Nagane M, Levitzki A, Gazit A, Cavenee WK, Huang HJ. Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases. Proc Natl Acad Sci U S A 1998; 95: 5724-5729.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 5724-5729
    • Nagane, M.1    Levitzki, A.2    Gazit, A.3    Cavenee, W.K.4    Huang, H.J.5
  • 213
    • 2342591455 scopus 로고    scopus 로고
    • The discovery of receptor tyrosine kinases: Targets for cancer therapy
    • Gschwind A, Fischer OM, Ullrich A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nature Rev Cancer 2004; 4: 361-370.
    • (2004) Nature Rev. Cancer , vol.4 , pp. 361-370
    • Gschwind, A.1    Fischer, O.M.2    Ullrich, A.3
  • 215
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351: 337-345.
    • (2004) N. Engl. J. Med. , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3    Khayat, D.4    Bleiberg, H.5    Santoro, A.6
  • 216
    • 0034068319 scopus 로고    scopus 로고
    • Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
    • Ciardiello F, Caputo R, Bianco R, Damiano V, Pomatico G, De Placido S, et al. Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin Cancer Res 2000; 6: 2053-2063.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2053-2063
    • Ciardiello, F.1    Caputo, R.2    Bianco, R.3    Damiano, V.4    Pomatico, G.5    De Placido, S.6
  • 217
    • 0345734200 scopus 로고    scopus 로고
    • Synergistic interaction between the EGFR tyrosine kinase inhibitor gefitinib ('Iressa') and the DNA topoisomerase I inhibitor CPT-11 (irinotecan) in human colorectal cancer cells
    • Koizumi F, Kanzawa F, Ueda Y, Koh Y, Tsukiyama S, Taguchi F, et al. Synergistic interaction between the EGFR tyrosine kinase inhibitor gefitinib ('Iressa') and the DNA topoisomerase I inhibitor CPT-11 (irinotecan) in human colorectal cancer cells. Int J Cancer 2004; 108: 464-472.
    • (2004) Int. J. Cancer , vol.108 , pp. 464-472
    • Koizumi, F.1    Kanzawa, F.2    Ueda, Y.3    Koh, Y.4    Tsukiyama, S.5    Taguchi, F.6
  • 218
    • 0037017877 scopus 로고    scopus 로고
    • Sequence-dependent effects of ZD1839 ('Iressa') in combination with cytotoxic treatment in human head and neck cancer
    • Magne N, Fischel JL, Dubreuil A, Formento P, Marcie S, Lagrange JL, et al. Sequence-dependent effects of ZD1839 ('Iressa') in combination with cytotoxic treatment in human head and neck cancer. Br J Cancer 2002; 86: 819-827.
    • (2002) Br. J. Cancer , vol.86 , pp. 819-827
    • Magne, N.1    Fischel, J.L.2    Dubreuil, A.3    Formento, P.4    Marcie, S.5    Lagrange, J.L.6
  • 219
    • 0034489914 scopus 로고    scopus 로고
    • Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase
    • Sirotnak FM, Zakowski MF, Miller VA, Scher HI, Kris MG. Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase. Clin Cancer Res 2000; 6: 4885-4892.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 4885-4892
    • Sirotnak, F.M.1    Zakowski, M.F.2    Miller, V.A.3    Scher, H.I.4    Kris, M.G.5
  • 220
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2
    • Herbst RS, Giaccone G, Schiller JH, Natale RB, Miller V, Manegold C, et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 2. J Clin Oncol 2004; 22: 785-794.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 785-794
    • Herbst, R.S.1    Giaccone, G.2    Schiller, J.H.3    Natale, R.B.4    Miller, V.5    Manegold, C.6
  • 221
    • 1542503746 scopus 로고    scopus 로고
    • Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 1
    • Giaccone G, Herbst RS, Manegold C, Scagliotti G, Rosell R, Miller V, et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 1. J Clin Oncol 2004; 22: 777-784.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 777-784
    • Giaccone, G.1    Herbst, R.S.2    Manegold, C.3    Scagliotti, G.4    Rosell, R.5    Miller, V.6
  • 222
    • 0036185848 scopus 로고    scopus 로고
    • The protein kinase B/Akt signalling pathway in human malignancy
    • Nicholson KM, Anderson NG. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 2002; 14: 381-395.
    • (2002) Cell Signal , vol.14 , pp. 381-395
    • Nicholson, K.M.1    Anderson, N.G.2
  • 223
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296: 1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 224
    • 0034326803 scopus 로고    scopus 로고
    • Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin
    • Hayakawa J, Ohmichi M, Kurachi H, Kanda Y, Hisamoto K, Nishio Y, et al. Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin. Cancer Res 2000; 60: 5988-5994.
    • (2000) Cancer Res. , vol.60 , pp. 5988-5994
    • Hayakawa, J.1    Ohmichi, M.2    Kurachi, H.3    Kanda, Y.4    Hisamoto, K.5    Nishio, Y.6
  • 225
    • 0034921007 scopus 로고    scopus 로고
    • Tumor suppressor PTEN: Modulator of cell signaling, growth, migration and apoptosis
    • Yamada KM, Araki M. Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. J Cell Sci 2001; 114 2375-2382.
    • (2001) J. Cell Sci. , vol.114 , pp. 2375-2382
    • Yamada, K.M.1    Araki, M.2
  • 226
    • 0034027514 scopus 로고    scopus 로고
    • Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis
    • Page C, Lin HJ, Jin Y, Castle VP, Nunez G, Huang M, et al. Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis. Anticancer Res 2000; 20: 407-416.
    • (2000) Anticancer Res. , vol.20 , pp. 407-416
    • Page, C.1    Lin, H.J.2    Jin, Y.3    Castle, V.P.4    Nunez, G.5    Huang, M.6
  • 227
    • 0034792844 scopus 로고    scopus 로고
    • Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice
    • Ng SS, Tsao MS, Nicklee T, Hedley DW. Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice. Clin Cancer Res 2001; 7: 3269-3275.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3269-3275
    • Ng, S.S.1    Tsao, M.S.2    Nicklee, T.3    Hedley, D.W.4
  • 228
    • 10744231026 scopus 로고    scopus 로고
    • Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)-mediated signaling pathway
    • Nguyen DM, Chen GA, Reddy R, Tsai W, Schrump WD, Cole G Jr, et al. Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)-mediated signaling pathway. J Thorac Cardiovasc Surg 2004; 127: 365-375.
    • (2004) J. Thorac. Cardiovasc. Surg. , vol.127 , pp. 365-375
    • Nguyen, D.M.1    Chen, G.A.2    Reddy, R.3    Tsai, W.4    Schrump, W.D.5    Cole Jr., G.6
  • 230
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer - New molecular targets come of age
    • Yu H, Jove R. The STATs of cancer - new molecular targets come of age. Nature Rev Cancer 2004; 4: 97-105.
    • (2004) Nature Rev. Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 232
    • 18644380911 scopus 로고    scopus 로고
    • Roles of activated Stc and Stat3 signaling in melanoma tumor cell growth
    • Niu G, Bowman T, Huang M, Shivers S, Reintgen D, Daud A, et al. Roles of activated Stc and Stat3 signaling in melanoma tumor cell growth. Oncogene 2002; 21: 7001-7010.
    • (2002) Oncogene , vol.21 , pp. 7001-7010
    • Niu, G.1    Bowman, T.2    Huang, M.3    Shivers, S.4    Reintgen, D.5    Daud, A.6
  • 233
    • 0034689031 scopus 로고    scopus 로고
    • Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL
    • Horita M, Andreu EJ, Benito A, Arbona C, Sanz C, Benet I, et al. Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL. J Exp Med 2000; 191: 977-984.
    • (2000) J. Exp. Med. , vol.191 , pp. 977-984
    • Horita, M.1    Andreu, E.J.2    Benito, A.3    Arbona, C.4    Sanz, C.5    Benet, I.6
  • 235
    • 0034665780 scopus 로고    scopus 로고
    • Bcr/Abl activates transcription of the Bcl-X gene through STAT5
    • Gesbert F, Griffin JD. Bcr/Abl activates transcription of the Bcl-X gene through STAT5. Blood 2000; 96: 2269-76.
    • (2000) Blood , vol.96 , pp. 2269-2276
    • Gesbert, F.1    Griffin, J.D.2
  • 236
    • 85047699293 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
    • Zamo A, Chiarle R, Piva R, Howes J, Fan Y, Chilosi M, et al. Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death. Oncogene 2002; 21: 1038-1047.
    • (2002) Oncogene , vol.21 , pp. 1038-1047
    • Zamo, A.1    Chiarle, R.2    Piva, R.3    Howes, J.4    Fan, Y.5    Chilosi, M.6
  • 237
    • 0037069942 scopus 로고    scopus 로고
    • Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells
    • Huang M, Dorsey JF, Epling-Burnette PK, Nimmanapalli R, Landowski TH, Mora LB, et al. Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells. Oncogene 2002; 21: 8804-8816.
    • (2002) Oncogene , vol.21 , pp. 8804-8816
    • Huang, M.1    Dorsey, J.F.2    Epling-Burnette, P.K.3    Nimmanapalli, R.4    Landowski, T.H.5    Mora, L.B.6
  • 238
    • 0037206950 scopus 로고    scopus 로고
    • Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells
    • Real PJ, Sierra A, De Juan A, Segovia JC, Lopez-Vega JM, Fernandez-Luna JL. Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells. Oncogene 2002; 21: 7611-7618.
    • (2002) Oncogene , vol.21 , pp. 7611-7618
    • Real, P.J.1    Sierra, A.2    De Juan, A.3    Segovia, J.C.4    Lopez-Vega, J.M.5    Fernandez-Luna, J.L.6
  • 239
    • 0036235654 scopus 로고    scopus 로고
    • The roles of JNK1 and Stat3 in the response of head and neck cancer cell lines to combined treatment with all-trans-retinoic acid and 5-fluorouracil
    • Masuda M, Toh S, Koike K, Kuratomi Y, Suzui M, Deguchi A, et al. The roles of JNK1 and Stat3 in the response of head and neck cancer cell lines to combined treatment with all-trans-retinoic acid and 5-fluorouracil. Jpn J Cancer Res 2002; 93: 329-339.
    • (2002) Jpn. J. Cancer Res. , vol.93 , pp. 329-339
    • Masuda, M.1    Toh, S.2    Koike, K.3    Kuratomi, Y.4    Suzui, M.5    Deguchi, A.6
  • 240
    • 0035852765 scopus 로고    scopus 로고
    • Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1
    • Shen Y, Devgan G, Darnell JE Jr, Bromberg JF. Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. Proc Natl Acad Sci U S A 2001; 98: 1543-1548.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 1543-1548
    • Shen, Y.1    Devgan, G.2    Darnell Jr., J.E.3    Bromberg, J.F.4
  • 241
    • 0037441888 scopus 로고    scopus 로고
    • Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma
    • Aoki Y, Feldman GM, Tosato, G. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood 2003; 101: 1535-1542.
    • (2003) Blood , vol.101 , pp. 1535-1542
    • Aoki, Y.1    Feldman, G.M.2    Tosato, G.3
  • 242
    • 0037376895 scopus 로고    scopus 로고
    • NF-kappaB in cancer: A marked target
    • Lin A, Karin M. NF-kappaB in cancer: a marked target. Semin Cancer Biol 2003; 13: 107-114.
    • (2003) Semin. Cancer Biol. , vol.13 , pp. 107-114
    • Lin, A.1    Karin, M.2
  • 243
    • 0036546501 scopus 로고    scopus 로고
    • NF-kappaB in cancer: From innocent bystander to major culprit
    • Karin M, Cao Y, Greten FR, Li ZW. NF-kappaB in cancer: from innocent bystander to major culprit. Nature Rev Cancer 2002; 2 301-310.
    • (2002) Nature Rev. Cancer , vol.2 , pp. 301-310
    • Karin, M.1    Cao, Y.2    Greten, F.R.3    Li, Z.W.4
  • 244
    • 0035137882 scopus 로고    scopus 로고
    • Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB
    • Baldwin AS. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J Clin Invest 2001; 107: 241-246.
    • (2001) J. Clin. Invest. , vol.107 , pp. 241-246
    • Baldwin, A.S.1
  • 245
    • 0036569563 scopus 로고    scopus 로고
    • Basal levels and patterns of anticancer drug-induced activation of nuclear factor-kappaB (NF-kappaB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells
    • Chuang SE, Yeh PY, Lu YS, Lai GM, Liao CM, Gao M, et al. Basal levels and patterns of anticancer drug-induced activation of nuclear factor-kappaB (NF-kappaB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells. Biochem Pharmacol 2002; 63: 1709-1716.
    • (2002) Biochem. Pharmacol. , vol.63 , pp. 1709-1716
    • Chuang, S.E.1    Yeh, P.Y.2    Lu, Y.S.3    Lai, G.M.4    Liao, C.M.5    Gao, M.6
  • 246
    • 0036164423 scopus 로고    scopus 로고
    • Inhibition of nuclear factor kappaB chemosensitizes non-small cell lung cancer through cytochrome c release and caspase activation
    • Jones DR, Broad RM, Comeau LD, Parsons SJ, Mayo MW. Inhibition of nuclear factor kappaB chemosensitizes non-small cell lung cancer through cytochrome c release and caspase activation. J Thorac Cardiovasc Surg 2002; 123: 310-317.
    • (2002) J. Thorac. Cardiovasc. Surg. , vol.123 , pp. 310-317
    • Jones, D.R.1    Broad, R.M.2    Comeau, L.D.3    Parsons, S.J.4    Mayo, M.W.5
  • 247
    • 0038621384 scopus 로고    scopus 로고
    • Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death
    • Arlt A, Gehrz A, Muerkoster S, Vorndamm J, Kruse ML, Folsch UR, et al. Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene 2003; 22: 3243-3251.
    • (2003) Oncogene , vol.22 , pp. 3243-3251
    • Arlt, A.1    Gehrz, A.2    Muerkoster, S.3    Vorndamm, J.4    Kruse, M.L.5    Folsch, U.R.6
  • 248
    • 0033750514 scopus 로고    scopus 로고
    • Cisplatin and radiation sensitivity in human head and neck squamous carcinomas are independently modulated by glutathione and transcription factor NF-kappaB
    • Kato T, Duffey DC, Ondrey FG, Dong G, Chen Z, Cook JA, et al. Cisplatin and radiation sensitivity in human head and neck squamous carcinomas are independently modulated by glutathione and transcription factor NF-kappaB. Head Neck 2000; 22: 748-759.
    • (2000) Head Neck , vol.22 , pp. 748-759
    • Kato, T.1    Duffey, D.C.2    Ondrey, F.G.3    Dong, G.4    Chen, Z.5    Cook, J.A.6
  • 249
    • 1642334954 scopus 로고    scopus 로고
    • NF-kappaB activation in esophageal adenocarcinoma: Relationship to Barrett's metaplasia, survival, and response to neoadjuvant chemoradiotherapy
    • Abdel-Latif MM, O'Riordan J, Windle HJ, Carton E, Ravi N, Kelleher D, et al. NF-kappaB activation in esophageal adenocarcinoma: relationship to Barrett's metaplasia, survival, and response to neoadjuvant chemoradiotherapy. Ann Surg 2004; 239 491-500.
    • (2004) Ann. Surg. , vol.239 , pp. 491-500
    • Abdel-Latif, M.M.1    O'Riordan, J.2    Windle, H.J.3    Carton, E.4    Ravi, N.5    Kelleher, D.6
  • 250
    • 0038189917 scopus 로고    scopus 로고
    • Rationale for the treatment of solid tumors with the proteasome inhibitor bortezomib
    • Cusack JC. Rationale for the treatment of solid tumors with the proteasome inhibitor bortezomib. Cancer Treat Rev 2003; 29 Suppl 1): 21-31.
    • (2003) Cancer Treat. Rev. , vol.29 , Issue.SUPPL. 1 , pp. 21-31
    • Cusack, J.C.1
  • 251
    • 0038528620 scopus 로고    scopus 로고
    • Clinical update: Proteasome inhibitors in hematologic malignancies
    • Richardson P. Clinical update: proteasome inhibitors in hematologic malignancies. Cancer Treat Rev 2003; 29(Suppl 1): 33-39.
    • (2003) Cancer Treat. Rev. , vol.29 , Issue.SUPPL. 1 , pp. 33-39
    • Richardson, P.1
  • 252
    • 9144273781 scopus 로고    scopus 로고
    • Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin
    • Mariadason JM, Arango D, Shi Q, Wilson AJ, Corner GA, Nicholas C, et al. Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin. Cancer Res 2003; 63: 8791-8812.
    • (2003) Cancer Res. , vol.63 , pp. 8791-8812
    • Mariadason, J.M.1    Arango, D.2    Shi, Q.3    Wilson, A.J.4    Corner, G.A.5    Nicholas, C.6
  • 253
    • 0037451804 scopus 로고    scopus 로고
    • Cancer pharmacogenomics: Current and future applications
    • Watters JW, McLeod HL. Cancer pharmacogenomics: current and future applications. Biochim Biophys Acta 2003; 1603: 99-111.
    • (2003) Biochim. Biophys. Acta , vol.1603 , pp. 99-111
    • Watters, J.W.1    McLeod, H.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.