NEU3 sialidase is activated under hypoxia and protects skeletal muscle cells from apoptosis through the activation of the epidermal growth factor receptor signaling pathway and the hypoxia-inducible factor (HIF)-1α

Journal of Biological Chemistry

Volumn 288, Issue 5, 2013, Pages 3153-3162

  Scaringi, Raffaella ^a,b   Piccoli, Marco ^b   Papini, Nadia ^a,b   Cirillo, Federica ^b   Conforti, Erika ^b   Bergante, Sonia ^a,b   Tringali, Cristina ^a,b   Garatti, Andrea ^b   Gelfi, Cecilia ^a   Venerando, Bruno ^a,b   Menicanti, Lorenzo ^b   Tettamanti, Guido ^b   Anastasia, Luigi ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b IRCCS POLICLINICO SAN DONATO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RESISTANCE; CELL SURVIVAL; DATA SUPPORT; EPIDERMAL GROWTH FACTOR RECEPTORS; HYPOXIA-INDUCIBLE FACTORS; HYPOXIC CONDITION; HYPOXIC STRESS; KEY ENZYMES; OVER-EXPRESSION; RECEPTOR SIGNALING; SIALIDASES; SKELETAL MUSCLE CELLS; THERAPEUTIC STRATEGY; UP-REGULATION;

BIOELECTRIC POTENTIALS; CARDIOVASCULAR SYSTEM; ENZYMES;

CELL DEATH;

CASPASE 3; CASPASE 7; EPIDERMAL GROWTH FACTOR RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NEU3 SIALIDASE; SIALIDASE; SPHINGOLIPID; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL HYPOXIA; CELL PROLIFERATION; CELL PROTECTION; CELL STRESS; CELL SURVIVAL; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; GENE SILENCING; ISCHEMIA; MOUSE; MUSCLE CELL; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASES; CELL HYPOXIA; CELL LINE; CELL PROLIFERATION; CYTOPROTECTION; ENZYME ACTIVATION; G(M3) GANGLIOSIDE; GENE SILENCING; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MODELS, BIOLOGICAL; MUSCLE CELLS; MUSCLE, SKELETAL; NEURAMINIDASE; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIALYLTRANSFERASES; SIGNAL TRANSDUCTION; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; SPHINGOLIPIDS; UP-REGULATION;

EID: 84873305472     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.404327     Document Type: Article

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