Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death

Cell Death and Differentiation

Volumn 17, Issue 4, 2010, Pages 642-654

  Lafont, E ^a,b   Milhas, D ^a,b   Carpentier, S ^a,b   Garcia, V ^a,b   Jin, Z X ^c   Umehara, H ^c   Okazaki, T ^d   Schulze Osthoff, K ^e   Levade, T ^a,b   Benoist, H ^a,b,f   Segui B ^a,b,f  

^a INSERM   (France)

^b Institut de Médecine Molé Culaire de Rangueil   (France)

^c KANAZAWA MEDICAL UNIVERSITY   (Japan)

^d TOTTORI UNIVERSITY   (Japan)

^e UNIVERSITY OF TÜBINGEN   (Germany)

^f UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

Apoptosis; Cancer cells; CD95; Ceramide; Sphingomyelin synthase 1

Indexed keywords

CASPASE 8; CASPASE 9; CERAMIDE; FAS LIGAND; SMALL INTERFERING RNA; SPHINGOMYELIN; SPHINGOMYELIN SYNTHASE 1; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GOLGI COMPLEX; HELA CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LIPID METABOLISM; LIPOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; REGULATORY MECHANISM; WESTERN BLOTTING;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; CASPASES; CERAMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FAS LIGAND PROTEIN; GOLGI APPARATUS; HELA CELLS; HUMANS; JURKAT CELLS; LEUKEMIA; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SPHINGOMYELINS; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

EID: 77949541016     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2009.130     Document Type: Article

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