-
1
-
-
0015514472
-
The fluid mosaic model of the structure of cell membranes
-
S.J. Singer, and G.L. Nicolson The fluid mosaic model of the structure of cell membranes Science 175 1972 720 731
-
(1972)
Science
, vol.175
, pp. 720-731
-
-
Singer, S.J.1
Nicolson, G.L.2
-
2
-
-
0019336197
-
Sphingomyelins in bilayers and biological membranes
-
Y. Barenholz, and T.E. Thompson Sphingomyelins in bilayers and biological membranes Biochim. Biophys. Acta 604 1980 129 158
-
(1980)
Biochim. Biophys. Acta
, vol.604
, pp. 129-158
-
-
Barenholz, Y.1
Thompson, T.E.2
-
3
-
-
0030949124
-
Functional rafts in cell membranes
-
K. Simons, and E. Ikonen Functional rafts in cell membranes Nature 387 1997 569 572
-
(1997)
Nature
, vol.387
, pp. 569-572
-
-
Simons, K.1
Ikonen, E.2
-
4
-
-
0030878573
-
Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains
-
T. Harder, and K. Simons Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains Curr. Opin. Cell Biol. 9 1997 534 542
-
(1997)
Curr. Opin. Cell Biol.
, vol.9
, pp. 534-542
-
-
Harder, T.1
Simons, K.2
-
5
-
-
0032421354
-
Functions of lipid rafts in biological membranes
-
D.A. Brown, and E. London Functions of lipid rafts in biological membranes Annu. Rev. Cell Dev. Biol. 14 1998 111 136
-
(1998)
Annu. Rev. Cell Dev. Biol.
, vol.14
, pp. 111-136
-
-
Brown, D.A.1
London, E.2
-
6
-
-
0031692336
-
The caveolae membrane system
-
R.G. Anderson The caveolae membrane system Annu. Rev. Biochem. 67 1998 199 225
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 199-225
-
-
Anderson, R.G.1
-
7
-
-
0025019247
-
Sphingomyelin is synthesized in the cis Golgi
-
D. Jeckel, A. Karrenbauer, R. Birk, R.R. Schmidt, and F. Wieland Sphingomyelin is synthesized in the cis Golgi FEBS Lett. 261 1990 155 157
-
(1990)
FEBS Lett.
, vol.261
, pp. 155-157
-
-
Jeckel, D.1
Karrenbauer, A.2
Birk, R.3
Schmidt, R.R.4
Wieland, F.5
-
8
-
-
0025323167
-
Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus
-
A.H. Futerman, B. Stieger, A.L. Hubbard, and R.E. Pagano Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus J. Biol. Chem. 265 1990 8650 8657
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 8650-8657
-
-
Futerman, A.H.1
Stieger, B.2
Hubbard, A.L.3
Pagano, R.E.4
-
9
-
-
0016504027
-
Phospholipid unsaturation and plasma membrane organization
-
P. Emmelot, and R.P. Van Hoeven Phospholipid unsaturation and plasma membrane organization Chem. Phys. Lipids 14 1975 236 246
-
(1975)
Chem. Phys. Lipids
, vol.14
, pp. 236-246
-
-
Emmelot, P.1
Van Hoeven, R.P.2
-
10
-
-
0026512314
-
Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
-
D.A. Brown, and J.K. Rose Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface Cell 68 1992 533 544
-
(1992)
Cell
, vol.68
, pp. 533-544
-
-
Brown, D.A.1
Rose, J.K.2
-
11
-
-
0036231656
-
The size of lipid rafts: An atomic force microscopy study of ganglioside GM1 domains in sphingomyelin/DOPC/cholesterol membranes
-
C. Yuan, J. Furlong, P. Burgos, and L.J. Johnston The size of lipid rafts: an atomic force microscopy study of ganglioside GM1 domains in sphingomyelin/DOPC/cholesterol membranes Biophys. J. 82 2002 2526 2535
-
(2002)
Biophys. J.
, vol.82
, pp. 2526-2535
-
-
Yuan, C.1
Furlong, J.2
Burgos, P.3
Johnston, L.J.4
-
12
-
-
0021075649
-
Cellular localization of GM1-ganglioside with biotinylated choleragen and avidin peroxidase in primary cultured cells from rat brain
-
H. Asou, E.G. Brunngraber, and I. Jeng Cellular localization of GM1-ganglioside with biotinylated choleragen and avidin peroxidase in primary cultured cells from rat brain J. Histochem. Cytochem. 31 1983 1375 1379
-
(1983)
J. Histochem. Cytochem.
, vol.31
, pp. 1375-1379
-
-
Asou, H.1
Brunngraber, E.G.2
Jeng, I.3
-
13
-
-
0344585437
-
Lipid rafts: Elusive or illusive?
-
S. Munro Lipid rafts: elusive or illusive? Cell 115 2003 377 388
-
(2003)
Cell
, vol.115
, pp. 377-388
-
-
Munro, S.1
-
14
-
-
0032817224
-
Ceramides modulate protein kinase C activity and perturb the structure of phosphatidylcholine/phosphatidylserine bilayers
-
H.W. Huang, E.M. Goldberg, and R. Zidovetzki Ceramides modulate protein kinase C activity and perturb the structure of phosphatidylcholine/ phosphatidylserine bilayers Biophys. J. 77 1999 1489 1497
-
(1999)
Biophys. J.
, vol.77
, pp. 1489-1497
-
-
Huang, H.W.1
Goldberg, E.M.2
Zidovetzki, R.3
-
15
-
-
0032939644
-
Ceramides in phospholipid membranes: Effects on bilayer stability and transition to nonlamellar phases
-
M.P. Veiga, J.L. Arrondo, F.M. Goni, and A. Alonso Ceramides in phospholipid membranes: effects on bilayer stability and transition to nonlamellar phases Biophys. J. 76 1999 342 350
-
(1999)
Biophys. J.
, vol.76
, pp. 342-350
-
-
Veiga, M.P.1
Arrondo, J.L.2
Goni, F.M.3
Alonso, A.4
-
16
-
-
0029737947
-
Phase behavior of stratum corneum lipids in mixed Langmuir-Blodgett monolayers
-
E. ten Grotenhuis, R.A. Demel, M. Ponec, D.R. Boer, J.C. van Miltenberg, and J.A. Bouwstra Phase behavior of stratum corneum lipids in mixed Langmuir-Blodgett monolayers Biophys. J. 71 1996 1389 1399
-
(1996)
Biophys. J.
, vol.71
, pp. 1389-1399
-
-
Ten Grotenhuis, E.1
Demel, R.A.2
Ponec, M.3
Boer, D.R.4
Van Miltenberg, J.C.5
Bouwstra, J.A.6
-
17
-
-
0028784298
-
Compartmentalized production of ceramide at the cell surface
-
P. Liu, and R.G. Anderson Compartmentalized production of ceramide at the cell surface J. Biol. Chem. 270 1995 27179 27185
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 27179-27185
-
-
Liu, P.1
Anderson, R.G.2
-
18
-
-
0037120891
-
Observation of topical catalysis by sphingomyelinase coupled to microspheres
-
T.A. Nurminen, J.M. Holopainen, H. Zhao, and P.K. Kinnunen Observation of topical catalysis by sphingomyelinase coupled to microspheres J. Am. Chem. Soc. 124 2002 12129 12134
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 12129-12134
-
-
Nurminen, T.A.1
Holopainen, J.M.2
Zhao, H.3
Kinnunen, P.K.4
-
19
-
-
0035827632
-
CD95 signaling via ceramide-rich membrane rafts
-
H. Grassmé, A. Jekle, A. Riehle, H. Schwarz, J. Berger, K. Sandhoff, R. Kolesnick, and E. Gulbins CD95 signaling via ceramide-rich membrane rafts J. Biol. Chem. 276 2001 20589 20596
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 20589-20596
-
-
Grassmé, H.1
Jekle, A.2
Riehle, A.3
Schwarz, H.4
Berger, J.5
Sandhoff, K.6
Kolesnick, R.7
Gulbins, E.8
-
20
-
-
0035968191
-
Ceramide enables fas to cap and kill
-
A. Cremesti, F. Paris, H. Grassmé, N. Holler, J. Tschopp, Z. Fuks, E. Gulbins, and R. Kolesnick Ceramide enables fas to cap and kill J. Biol. Chem. 276 2001 23954 23961
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 23954-23961
-
-
Cremesti, A.1
Paris, F.2
Grassmé, H.3
Holler, N.4
Tschopp, J.5
Fuks, Z.6
Gulbins, E.7
Kolesnick, R.8
-
22
-
-
0038581115
-
Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms
-
J. Bock, I. Szabo, N. Gamper, C. Adams, and E. Gulbins Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms Biochem. Biophys. Res. Commun. 305 2003 890 897
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.305
, pp. 890-897
-
-
Bock, J.1
Szabo, I.2
Gamper, N.3
Adams, C.4
Gulbins, E.5
-
23
-
-
0036134864
-
Ceramide-rich membrane rafts mediate CD40 clustering
-
H. Grassmé, V. Jendrossek, J. Bock, A. Riehle, and E. Gulbins Ceramide-rich membrane rafts mediate CD40 clustering J. Immunol. 168 2002 298 307
-
(2002)
J. Immunol.
, vol.168
, pp. 298-307
-
-
Grassmé, H.1
Jendrossek, V.2
Bock, J.3
Riehle, A.4
Gulbins, E.5
-
24
-
-
0142095498
-
Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts
-
H. Grassmé, V. Jendrossek, A. Riehle, G. von Kurthy, J. Berger, H. Schwarz, M. Weller, R. Kolesnick, and E. Gulbins Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts Nat. Med. 9 2003 322 330
-
(2003)
Nat. Med.
, vol.9
, pp. 322-330
-
-
Grassmé, H.1
Jendrossek, V.2
Riehle, A.3
Von Kurthy, G.4
Berger, J.5
Schwarz, H.6
Weller, M.7
Kolesnick, R.8
Gulbins, E.9
-
25
-
-
0042335762
-
Ceramide-mediated clustering is required for CD95-DISC formation
-
H. Grassmé, A. Cremesti, R. Kolesnick, and E. Gulbins Ceramide-mediated clustering is required for CD95-DISC formation Oncogene 22 2003 5457 5470
-
(2003)
Oncogene
, vol.22
, pp. 5457-5470
-
-
Grassmé, H.1
Cremesti, A.2
Kolesnick, R.3
Gulbins, E.4
-
26
-
-
2442693091
-
Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells
-
S. Lacour, A. Hammann, S. Grazide, D. Lagadic-Gossmann, A. Athias, O. Sergent, G. Laurent, P. Gambert, E. Solary, and M.T. Dimanche-Boitrel Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells Cancer. Res. 64 2004 3593 3598
-
(2004)
Cancer. Res.
, vol.64
, pp. 3593-3598
-
-
Lacour, S.1
Hammann, A.2
Grazide, S.3
Lagadic-Gossmann, D.4
Athias, A.5
Sergent, O.6
Laurent, G.7
Gambert, P.8
Solary, E.9
Dimanche-Boitrel, M.T.10
-
27
-
-
3843139379
-
Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains
-
C. Bezombes, S. Grazide, C. Garret, C. Fabre, A. Quillet-Mary, S. Muller, J.P. Jaffrezou, and G. Laurent Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains Blood 104 2004 1166 1173
-
(2004)
Blood
, vol.104
, pp. 1166-1173
-
-
Bezombes, C.1
Grazide, S.2
Garret, C.3
Fabre, C.4
Quillet-Mary, A.5
Muller, S.6
Jaffrezou, J.P.7
Laurent, G.8
-
28
-
-
4344697840
-
Cell surface ceramide generation precedes and controls FcgammaRII clustering and phosphorylation in rafts
-
A.B. Abdel Shakor, K. Kwiatkowska, and A. Sobota Cell surface ceramide generation precedes and controls FcgammaRII clustering and phosphorylation in rafts J. Biol. Chem. 279 2004 36778 36787
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 36778-36787
-
-
Abdel Shakor, A.B.1
Kwiatkowska, K.2
Sobota, A.3
-
29
-
-
21444434296
-
UV-C light induces raft-associated acid Sphingomyelinase and JNK activation and translocation independently on a nuclear signal
-
A. Charruyer, S. Grazide, C. Bezombes, S. Muller, G. Laurent, and J.P. Jaffrezou UV-C light induces raft-associated acid Sphingomyelinase and JNK activation and translocation independently on a nuclear signal J. Biol. Chem. 280 2005 19196 19204
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 19196-19204
-
-
Charruyer, A.1
Grazide, S.2
Bezombes, C.3
Muller, S.4
Laurent, G.5
Jaffrezou, J.P.6
-
30
-
-
0028095477
-
Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase
-
M.G. Cifone, R. De Maria, P. Roncaioli, M.R. Rippo, M. Azuma, L.L. Lanier, A. Santoni, and R. Testi Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase J. Exp. Med. 180 1994 1547 1552
-
(1994)
J. Exp. Med.
, vol.180
, pp. 1547-1552
-
-
Cifone, M.G.1
De Maria, R.2
Roncaioli, P.3
Rippo, M.R.4
Azuma, M.5
Lanier, L.L.6
Santoni, A.7
Testi, R.8
-
31
-
-
0028964917
-
FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway
-
E. Gulbins, R. Bissonnette, A. Mahboubi, S. Martin, W. Nishioka, T. Brunner, G. Baier, G. Baier-Bitterlich, C. Byrd, F. Lang, R. Kolesnick, A. Altman, and D. Green FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway Immunity 2 1995 341 351
-
(1995)
Immunity
, vol.2
, pp. 341-351
-
-
Gulbins, E.1
Bissonnette, R.2
Mahboubi, A.3
Martin, S.4
Nishioka, W.5
Brunner, T.6
Baier, G.7
Baier-Bitterlich, G.8
Byrd, C.9
Lang, F.10
Kolesnick, R.11
Altman, A.12
Green, D.13
-
32
-
-
0033924879
-
Measurement of sphingomyelinase activity
-
E. Gulbins, and R. Kolesnick Measurement of sphingomyelinase activity Methods Enzymol. 322 2000 382 388
-
(2000)
Methods Enzymol.
, vol.322
, pp. 382-388
-
-
Gulbins, E.1
Kolesnick, R.2
-
33
-
-
0032535156
-
Sphingomyelinase induces lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane
-
J.M. Holopainen, M. Subramanian, and P.K. Kinnunen Sphingomyelinase induces lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane Biochemistry 37 1998 17562 17570
-
(1998)
Biochemistry
, vol.37
, pp. 17562-17570
-
-
Holopainen, J.M.1
Subramanian, M.2
Kinnunen, P.K.3
-
34
-
-
0033884050
-
Compartmentalization of ceramide signaling: Physical foundations and biological effects
-
R.N. Kolesnick, F.M. Goni, and A. Alonso Compartmentalization of ceramide signaling: physical foundations and biological effects J. Cell. Physiol. 184 2000 285 300
-
(2000)
J. Cell. Physiol.
, vol.184
, pp. 285-300
-
-
Kolesnick, R.N.1
Goni, F.M.2
Alonso, A.3
-
35
-
-
0035823586
-
Effect of the structure of natural sterols and sphingolipids on the formation of ordered sphingolipid/sterol domains (rafts). Comparison of cholesterol to plant, fungal, and disease-associated sterols and comparison of sphingomyelin, cerebrosides, and ceramide
-
X. Xu, R. Bittman, G. Duportail, D. Heissler, C. Vilcheze, and E. London Effect of the structure of natural sterols and sphingolipids on the formation of ordered sphingolipid/sterol domains (rafts). Comparison of cholesterol to plant, fungal, and disease-associated sterols and comparison of sphingomyelin, cerebrosides, and ceramide J. Biol. Chem. 276 2001 33540 33546
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 33540-33546
-
-
Xu, X.1
Bittman, R.2
Duportail, G.3
Heissler, D.4
Vilcheze, C.5
London, E.6
-
36
-
-
1642293929
-
Ceramide selectively displaces cholesterol from ordered lipid domains (rafts): Implications for lipid raft structure and function
-
Megha, and E. London Ceramide selectively displaces cholesterol from ordered lipid domains (rafts): implications for lipid raft structure and function J. Biol. Chem. 279 2004 9997 10004
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 9997-10004
-
-
Megha1
London, E.2
-
37
-
-
0242472336
-
-
(submitted for publication).
-
A. Cremesti, J. Zhang, H. Lee, J.A. Rotolo, V. Jendrossek, T. McNabb, A. Amoscato, H. Grassmé, C. Belka, Z. Fuks, E. Gulbins, R. Kolesnick, Fas activation induces surface ceramide elevation in discrete microdomains (submitted for publication).
-
Fas Activation Induces Surface Ceramide Elevation in Discrete Microdomains
-
-
Cremesti, A.1
Zhang, J.2
Lee, H.3
Rotolo, J.A.4
Jendrossek, V.5
McNabb, T.6
Amoscato, A.7
Grassmé, H.8
Belka, C.9
Fuks, Z.10
Gulbins, E.11
Kolesnick, R.12
-
38
-
-
0034708831
-
Role of acidic sphingomyelinase in Fas/CD95-mediated cell death
-
T. Lin, L. Genestier, M.J. Pinkoski, A. Castro, S. Nicholas, R. Mogil, F. Paris, Z. Fuks, E.H. Schuchman, R.N. Kolesnick, and D.R. Green Role of acidic sphingomyelinase in Fas/CD95-mediated cell death J. Biol. Chem. 275 2000 8657 8663
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8657-8663
-
-
Lin, T.1
Genestier, L.2
Pinkoski, M.J.3
Castro, A.4
Nicholas, S.5
Mogil, R.6
Paris, F.7
Fuks, Z.8
Schuchman, E.H.9
Kolesnick, R.N.10
Green, D.R.11
-
39
-
-
0035896515
-
Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes
-
F. Paris, H. Grassmé, A. Cremesti, J. Zager, Y. Fong, A. Haimovitz-Friedman, Z. Fuks, E. Gulbins, and R. Kolesnick Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes J. Biol. Chem. 276 2001 8297 8305
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 8297-8305
-
-
Paris, F.1
Grassmé, H.2
Cremesti, A.3
Zager, J.4
Fong, Y.5
Haimovitz-Friedman, A.6
Fuks, Z.7
Gulbins, E.8
Kolesnick, R.9
-
40
-
-
0034282716
-
CD95-mediated apoptosis in vivo involves acid sphingomyelinase
-
S. Kirschnek, F. Paris, M. Weller, H. Grassmé, K. Ferlinz, A. Riehle, Z. Fuks, R. Kolesnick, and E. Gulbins CD95-mediated apoptosis in vivo involves acid sphingomyelinase J. Biol. Chem. 275 2000 27316 27323
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 27316-27323
-
-
Kirschnek, S.1
Paris, F.2
Weller, M.3
Grassmé, H.4
Ferlinz, K.5
Riehle, A.6
Fuks, Z.7
Kolesnick, R.8
Gulbins, E.9
-
42
-
-
0033137104
-
Signaling through CD5 involves acidic sphingomyelinase, protein kinase C-zeta, mitogen-activated protein kinase kinase, and c-Jun NH2-terminal kinase
-
M. Simarro, J. Calvo, J.M. Vila, L. Places, O. Padilla, J. Alberola-Ila, J. Vives, and F. Lozano Signaling through CD5 involves acidic sphingomyelinase, protein kinase C-zeta, mitogen-activated protein kinase kinase, and c-Jun NH2-terminal kinase J. Immunol. 162 1999 5149 5155
-
(1999)
J. Immunol.
, vol.162
, pp. 5149-5155
-
-
Simarro, M.1
Calvo, J.2
Vila, J.M.3
Places, L.4
Padilla, O.5
Alberola-Ila, J.6
Vives, J.7
Lozano, F.8
-
43
-
-
0033136777
-
Signaling pathways activated by leukocyte function-associated Ag-1-dependent costimulation
-
H.T. Ni, M.J. Deeths, W. Li, D.L. Mueller, and M.F. Mescher Signaling pathways activated by leukocyte function-associated Ag-1-dependent costimulation J. Immunol. 162 1999 5183 5189
-
(1999)
J. Immunol.
, vol.162
, pp. 5183-5189
-
-
Ni, H.T.1
Deeths, M.J.2
Li, W.3
Mueller, D.L.4
Mescher, M.F.5
-
44
-
-
0029036715
-
CD28 signals through acidic sphingomyelinase
-
L.M. Boucher, K. Wiegmann, A. Futterer, K. Pfeffer, T. Machleidt, S. Schutze, T.W. Mak, and M. Kronke CD28 signals through acidic sphingomyelinase J. Exp. Med. 181 1995 2059 2068
-
(1995)
J. Exp. Med.
, vol.181
, pp. 2059-2068
-
-
Boucher, L.M.1
Wiegmann, K.2
Futterer, A.3
Pfeffer, K.4
MacHleidt, T.5
Schutze, S.6
Mak, T.W.7
Kronke, M.8
-
45
-
-
0026458406
-
TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown
-
S. Schutze, K. Potthoff, T. Machleidt, D. Berkovic, K. Wiegmann, and M. Kronke TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown Cell 71 1992 765 776
-
(1992)
Cell
, vol.71
, pp. 765-776
-
-
Schutze, S.1
Potthoff, K.2
MacHleidt, T.3
Berkovic, D.4
Wiegmann, K.5
Kronke, M.6
-
46
-
-
0037237733
-
Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice
-
C. Garcia-Ruiz, A. Colell, M. Mari, A. Morales, M. Calvo, C. Enrich, and J.C. Fernandez-Checa Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice J. Clin. Invest. 111 2003 197 208
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 197-208
-
-
Garcia-Ruiz, C.1
Colell, A.2
Mari, M.3
Morales, A.4
Calvo, M.5
Enrich, C.6
Fernandez-Checa, J.C.7
-
47
-
-
0036838876
-
Role of ceramide in TNF-alpha-induced impairment of endothelium-dependent vasorelaxation in coronary arteries
-
D.X. Zhang, F.X. Yi, A.P. Zou, and P.L. Li Role of ceramide in TNF-alpha-induced impairment of endothelium-dependent vasorelaxation in coronary arteries Am. J. Physiol.: Heart Circ. Physiol. 283 2002 H1785 H1794
-
(2002)
Am. J. Physiol.: Heart Circ. Physiol.
, vol.283
-
-
Zhang, D.X.1
Yi, F.X.2
Zou, A.P.3
Li, P.L.4
-
48
-
-
0027461121
-
Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta
-
S. Mathias, A. Younes, C.C. Kan, I. Orlow, C. Joseph, and R.N. Kolesnick Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta Science 259 1993 519 522
-
(1993)
Science
, vol.259
, pp. 519-522
-
-
Mathias, S.1
Younes, A.2
Kan, C.C.3
Orlow, I.4
Joseph, C.5
Kolesnick, R.N.6
-
49
-
-
11144354259
-
PAF-mediated pulmonary edema: A new role for acid sphingomyelinase and ceramide
-
R. Goggel, S. Winoto-Morbach, G. Vielhaber, Y. Imai, K. Lindner, L. Brade, H. Brade, S. Ehlers, A.S. Slutsky, S. Schutze, E. Gulbins, and S. Uhlig PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide Nat. Med. 10 2004 155 160
-
(2004)
Nat. Med.
, vol.10
, pp. 155-160
-
-
Goggel, R.1
Winoto-Morbach, S.2
Vielhaber, G.3
Imai, Y.4
Lindner, K.5
Brade, L.6
Brade, H.7
Ehlers, S.8
Slutsky, A.S.9
Schutze, S.10
Gulbins, E.11
Uhlig, S.12
-
50
-
-
0035191769
-
Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts
-
A. Pfeiffer, A. Bottcher, E. Orso, M. Kapinsky, P. Nagy, A. Bodnar, I. Spreitzer, G. Liebisch, W. Drobnik, K. Gempel, M. Horn, S. Holmer, T. Hartung, G. Multhoff, G. Schutz, H. Schindler, A.J. Ulmer, H. Heine, F. Stelter, C. Schutt, G. Rothe, J. Szollosi, S. Damjanovich, and G. Schmitz Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts Eur. J. Immunol. 31 2001 3153 3164
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 3153-3164
-
-
Pfeiffer, A.1
Bottcher, A.2
Orso, E.3
Kapinsky, M.4
Nagy, P.5
Bodnar, A.6
Spreitzer, I.7
Liebisch, G.8
Drobnik, W.9
Gempel, K.10
Horn, M.11
Holmer, S.12
Hartung, T.13
Multhoff, G.14
Schutz, G.15
Schindler, H.16
Ulmer, A.J.17
Heine, H.18
Stelter, F.19
Schutt, C.20
Rothe, G.21
Szollosi, J.22
Damjanovich, S.23
Schmitz, G.24
more..
-
51
-
-
0035175328
-
Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells
-
M. Esen, B. Schreiner, V. Jendrossek, F. Lang, K. Fassbender, H. Grassmé, and E. Gulbins Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells Apoptosis 6 2001 431 439
-
(2001)
Apoptosis
, vol.6
, pp. 431-439
-
-
Esen, M.1
Schreiner, B.2
Jendrossek, V.3
Lang, F.4
Fassbender, K.5
Grassmé, H.6
Gulbins, E.7
-
52
-
-
0030775369
-
Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells
-
H. Grassmé, E. Gulbins, B. Brenner, K. Ferlinz, K. Sandhoff, K. Harzer, F. Lang, and T.F. Meyer Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells Cell 91 1997 605 615
-
(1997)
Cell
, vol.91
, pp. 605-615
-
-
Grassmé, H.1
Gulbins, E.2
Brenner, B.3
Ferlinz, K.4
Sandhoff, K.5
Harzer, K.6
Lang, F.7
Meyer, T.F.8
-
53
-
-
0034604554
-
Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeae
-
C.R. Hauck, H. Grassmé, J. Bock, V. Jendrossek, K. Ferlinz, T.F. Meyer, and E. Gulbins Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeae FEBS Lett. 478 2000 260 266
-
(2000)
FEBS Lett.
, vol.478
, pp. 260-266
-
-
Hauck, C.R.1
Grassmé, H.2
Bock, J.3
Jendrossek, V.4
Ferlinz, K.5
Meyer, T.F.6
Gulbins, E.7
-
54
-
-
0033918950
-
Sindbis virus entry into cells triggers apoptosis by activating sphingomyelinase, leading to the release of ceramide
-
J.T. Jan, S. Chatterjee, and D.E. Griffin Sindbis virus entry into cells triggers apoptosis by activating sphingomyelinase, leading to the release of ceramide J. Virol. 74 2000 6425 6432
-
(2000)
J. Virol.
, vol.74
, pp. 6425-6432
-
-
Jan, J.T.1
Chatterjee, S.2
Griffin, D.E.3
-
55
-
-
22544476850
-
Rhinoviruses infect human epithelial cells via ceramide-enriched membrane platforms
-
H. Grassmé, A. Riehle, B. Wilker, and E. Gulbins Rhinoviruses infect human epithelial cells via ceramide-enriched membrane platforms J. Biol. Chem. 280 2005 26256 26262
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 26256-26262
-
-
Grassmé, H.1
Riehle, A.2
Wilker, B.3
Gulbins, E.4
-
56
-
-
16044364385
-
Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
-
P. Santana, L.A. Pena, A. Haimovitz-Friedman, S. Martin, D. Green, M. McLoughlin, C. Cordon-Cardo, E.H. Schuchman, Z. Fuks, and R. Kolesnick Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis Cell 86 1996 189 199
-
(1996)
Cell
, vol.86
, pp. 189-199
-
-
Santana, P.1
Pena, L.A.2
Haimovitz-Friedman, A.3
Martin, S.4
Green, D.5
McLoughlin, M.6
Cordon-Cardo, C.7
Schuchman, E.H.8
Fuks, Z.9
Kolesnick, R.10
-
57
-
-
0035854479
-
Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice
-
F. Paris, Z. Fuks, A. Kang, P. Capodieci, G. Juan, D. Ehleiter, A. Haimovitz-Friedman, C. Cordon-Cardo, and R. Kolesnick Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice Science 293 2001 293 297
-
(2001)
Science
, vol.293
, pp. 293-297
-
-
Paris, F.1
Fuks, Z.2
Kang, A.3
Capodieci, P.4
Juan, G.5
Ehleiter, D.6
Haimovitz-Friedman, A.7
Cordon-Cardo, C.8
Kolesnick, R.9
-
58
-
-
0035853751
-
Involvement of the acid sphingomyelinase pathway in UVA-induced apoptosis
-
Y. Zhang, P. Mattjus, P.C. Schmid, Z. Dong, S. Zhong, W.Y. Ma, R.E. Brown, A.M. Bode, and H.H. Schmid Involvement of the acid sphingomyelinase pathway in UVA-induced apoptosis J. Biol. Chem. 276 2001 11775 11782
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 11775-11782
-
-
Zhang, Y.1
Mattjus, P.2
Schmid, P.C.3
Dong, Z.4
Zhong, S.5
Ma, W.Y.6
Brown, R.E.7
Bode, A.M.8
Schmid, H.H.9
-
59
-
-
22544470314
-
Caspase-dependent and -independent activation of acid sphingomyelinase signaling
-
J.A. Rotolo, J. Zhang, M. Donepudi, H. Lee, Z. Fuks, and R. Kolesnick Caspase-dependent and -independent activation of acid sphingomyelinase signaling J. Biol. Chem. 280 2005 26425 26434
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 26425-26434
-
-
Rotolo, J.A.1
Zhang, J.2
Donepudi, M.3
Lee, H.4
Fuks, Z.5
Kolesnick, R.6
-
60
-
-
0033786639
-
Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy
-
Y. Morita, G.I. Perez, F. Paris, S.R. Miranda, D. Ehleiter, A. Haimovitz-Friedman, Z. Fuks, Z. Xie, J.C. Reed, E.H. Schuchman, R.N. Kolesnick, and J.L. Tilly Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy Nat. Med. 6 2000 1109 1114
-
(2000)
Nat. Med.
, vol.6
, pp. 1109-1114
-
-
Morita, Y.1
Perez, G.I.2
Paris, F.3
Miranda, S.R.4
Ehleiter, D.5
Haimovitz-Friedman, A.6
Fuks, Z.7
Xie, Z.8
Reed, J.C.9
Schuchman, E.H.10
Kolesnick, R.N.11
Tilly, J.L.12
-
61
-
-
8544264614
-
Synergistic interaction between sphingomyelin and gemcitabine potentiates ceramide-mediated apoptosis in pancreatic cancer
-
D.E. Modrak, T.M. Cardillo, G.A. Newsome, D.M. Goldenberg, and D.V. Gold Synergistic interaction between sphingomyelin and gemcitabine potentiates ceramide-mediated apoptosis in pancreatic cancer Cancer Res. 64 2004 8405 8410
-
(2004)
Cancer Res.
, vol.64
, pp. 8405-8410
-
-
Modrak, D.E.1
Cardillo, T.M.2
Newsome, G.A.3
Goldenberg, D.M.4
Gold, D.V.5
-
62
-
-
19344363059
-
Endothelial apoptosis induced by inhibition of integrins αvβ3 and αvβ5 involves ceramide metabolic pathways
-
A. Erdreich-Epstein, L.B. Tran, O.T. Cox, E. Huang, W.E. Laug, H. Shimada, and M. Millard Endothelial apoptosis induced by inhibition of integrins αvβ3 and αvβ5 involves ceramide metabolic pathways Blood 105 2005 4353 4361
-
(2005)
Blood
, vol.105
, pp. 4353-4361
-
-
Erdreich-Epstein, A.1
Tran, L.B.2
Cox, O.T.3
Huang, E.4
Laug, W.E.5
Shimada, H.6
Millard, M.7
-
63
-
-
4944245910
-
Reactive oxygen species limit neutrophil life span by activating death receptor signaling
-
D. Scheel-Toellner, K. Wang, R. Craddock, P.R. Webb, H.M. McGettrick, L.K. Assi, N. Parkes, L.E. Clough, E. Gulbins, M. Salmon, and J.M. Lord Reactive oxygen species limit neutrophil life span by activating death receptor signaling Blood 104 2004 2557 2564
-
(2004)
Blood
, vol.104
, pp. 2557-2564
-
-
Scheel-Toellner, D.1
Wang, K.2
Craddock, R.3
Webb, P.R.4
McGettrick, H.M.5
Assi, L.K.6
Parkes, N.7
Clough, L.E.8
Gulbins, E.9
Salmon, M.10
Lord, J.M.11
-
64
-
-
0842300358
-
Caspase-3 is a component of Fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas-mediated cell death
-
S.M. Aouad, L.Y. Cohen, E. Sharif-Askari, E.K. Haddad, A. Alam, and R.P. Sekaly Caspase-3 is a component of Fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas-mediated cell death J. Immunol. 172 2004 2316 2323
-
(2004)
J. Immunol.
, vol.172
, pp. 2316-2323
-
-
Aouad, S.M.1
Cohen, L.Y.2
Sharif-Askari, E.3
Haddad, E.K.4
Alam, A.5
Sekaly, R.P.6
-
65
-
-
79960801799
-
CD95 rapidly clusters in cells of diverse origins
-
J.C. Fanzo, M.P. Lynch, H. Phee, M. Hyer, A. Cremesti, H. Grassmé, J.S. Norris, K.M. Coggeshall, B.R. Rueda, A.B. Pernis, R. Kolesnick, and E. Gulbins CD95 rapidly clusters in cells of diverse origins Cancer Biol. Ther. 2 2003 392 395
-
(2003)
Cancer Biol. Ther.
, vol.2
, pp. 392-395
-
-
Fanzo, J.C.1
Lynch, M.P.2
Phee, H.3
Hyer, M.4
Cremesti, A.5
Grassmé, H.6
Norris, J.S.7
Coggeshall, K.M.8
Rueda, B.R.9
Pernis, A.B.10
Kolesnick, R.11
Gulbins, E.12
-
66
-
-
0036195136
-
An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes
-
A.O. Hueber, A.M. Bernard, Z. Herincs, A. Couzinet, and H.T. He An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes EMBO Rep. 3 2002 190 196
-
(2002)
EMBO Rep.
, vol.3
, pp. 190-196
-
-
Hueber, A.O.1
Bernard, A.M.2
Herincs, Z.3
Couzinet, A.4
He, H.T.5
-
67
-
-
0037424543
-
Association of the death-inducing signaling complex with microdomains after triggering through CD95/Fas. Evidence for caspase-8-ganglioside interaction in T cells
-
T. Garofalo, R. Misasi, V. Mattei, A.M. Giammarioli, W. Malorni, G.M. Pontieri, A. Pavan, and M. Sorice Association of the death-inducing signaling complex with microdomains after triggering through CD95/Fas. Evidence for caspase-8-ganglioside interaction in T cells J. Biol. Chem. 278 2003 8309 8315
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 8309-8315
-
-
Garofalo, T.1
Misasi, R.2
Mattei, V.3
Giammarioli, A.M.4
Malorni, W.5
Pontieri, G.M.6
Pavan, A.7
Sorice, M.8
-
68
-
-
0036133127
-
Molecular ordering of the initial signaling events of CD95
-
A. Algeciras-Schimnich, L. Shen, B.C. Barnhart, A.E. Murmann, J.K. Burkhardt, and M.E. Peter Molecular ordering of the initial signaling events of CD95 Mol. Cell. Biol. 22 2002 207 220
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 207-220
-
-
Algeciras-Schimnich, A.1
Shen, L.2
Barnhart, B.C.3
Murmann, A.E.4
Burkhardt, J.K.5
Peter, M.E.6
-
69
-
-
0032571251
-
CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase
-
J.G.R. Boesen-de Cock, A.D. Tepper, E. de Vries, W.J. van Blitterswijk, and J. Borst CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase J. Biol. Chem. 273 1998 7560 7565
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 7560-7565
-
-
Boesen-De Cock, J.G.R.1
Tepper, A.D.2
De Vries, E.3
Van Blitterswijk, W.J.4
Borst, J.5
-
70
-
-
0034631827
-
Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology
-
A.D. Tepper, P. Ruurs, T. Wiedmer, P.J. Sims, J. Borst, and W.J. van Blitterswijk Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology J. Cell Biol. 150 2000 155 164
-
(2000)
J. Cell Biol.
, vol.150
, pp. 155-164
-
-
Tepper, A.D.1
Ruurs, P.2
Wiedmer, T.3
Sims, P.J.4
Borst, J.5
Van Blitterswijk, W.J.6
-
71
-
-
0035259441
-
Lysosomal sphingomyelinase is not solicited for apoptosis signaling
-
C. Bezombes, B. Segui, O. Cuvillier, A.P. Bruno, E. Uro-Coste, V. Gouaze, N. Andrieu-Abadie, S. Carpentier, G. Laurent, R. Salvayre, J.P. Jaffrezou, and T. Levade Lysosomal sphingomyelinase is not solicited for apoptosis signaling FASEB J. 15 2001 297 299
-
(2001)
FASEB J.
, vol.15
, pp. 297-299
-
-
Bezombes, C.1
Segui, B.2
Cuvillier, O.3
Bruno, A.P.4
Uro-Coste, E.5
Gouaze, V.6
Andrieu-Abadie, N.7
Carpentier, S.8
Laurent, G.9
Salvayre, R.10
Jaffrezou, J.P.11
Levade, T.12
-
72
-
-
0035808364
-
Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts
-
J. Lozano, S. Menendez, A. Morales, D. Ehleiter, W.C. Liao, R. Wagman, A. Haimovitz-Friedman, Z. Fuks, and R. Kolesnick Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts J. Biol. Chem. 276 2001 442 448
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 442-448
-
-
Lozano, J.1
Menendez, S.2
Morales, A.3
Ehleiter, D.4
Liao, W.C.5
Wagman, R.6
Haimovitz-Friedman, A.7
Fuks, Z.8
Kolesnick, R.9
-
73
-
-
0036732415
-
Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring
-
F. Paris, G.I. Perez, Z. Fuks, A. Haimovitz-Friedman, H. Nguyen, M. Bose, A. Ilagan, P.A. Hunt, W.F. Morgan, J.L. Tilly, and R. Kolesnick Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring Nat. Med. 8 2002 901 902
-
(2002)
Nat. Med.
, vol.8
, pp. 901-902
-
-
Paris, F.1
Perez, G.I.2
Fuks, Z.3
Haimovitz-Friedman, A.4
Nguyen, H.5
Bose, M.6
Ilagan, A.7
Hunt, P.A.8
Morgan, W.F.9
Tilly, J.L.10
Kolesnick, R.11
-
74
-
-
0342545909
-
Radiation-induced apoptosis of endothelial cells in the murine central nervous system: Protection by fibroblast growth factor and sphingomyelinase deficiency
-
L.A. Pena, Z. Fuks, and R.N. Kolesnick Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency Cancer Res. 60 2000 321 327
-
(2000)
Cancer Res.
, vol.60
, pp. 321-327
-
-
Pena, L.A.1
Fuks, Z.2
Kolesnick, R.N.3
-
75
-
-
0038626211
-
Tumor response to radiotherapy regulated by endothelial cell apoptosis
-
M. Garcia-Barros, F. Paris, C. Cordon-Cardo, D. Lyden, S. Rafii, A. Haimovitz-Friedman, Z. Fuks, and R. Kolesnick Tumor response to radiotherapy regulated by endothelial cell apoptosis Science 300 2003 1155 1159
-
(2003)
Science
, vol.300
, pp. 1155-1159
-
-
Garcia-Barros, M.1
Paris, F.2
Cordon-Cardo, C.3
Lyden, D.4
Rafii, S.5
Haimovitz-Friedman, A.6
Fuks, Z.7
Kolesnick, R.8
-
76
-
-
0031873198
-
Fas/CD95/Apo-I activates the acidic sphingomyelinase via caspases
-
B. Brenner, K. Ferlinz, H. Grassmé, M. Weller, U. Koppenhoefer, J. Dichgans, K. Sandhoff, F. Lang, and E. Gulbins Fas/CD95/Apo-I activates the acidic sphingomyelinase via caspases Cell Death Differ. 5 1998 29 37
-
(1998)
Cell Death Differ.
, vol.5
, pp. 29-37
-
-
Brenner, B.1
Ferlinz, K.2
Grassmé, H.3
Weller, M.4
Koppenhoefer, U.5
Dichgans, J.6
Sandhoff, K.7
Lang, F.8
Gulbins, E.9
-
77
-
-
0030011398
-
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
-
M.P. Boldin, T.M. Goncharov, Y.V. Goltsev, and D. Wallach Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death Cell 85 1996 803 815
-
(1996)
Cell
, vol.85
, pp. 803-815
-
-
Boldin, M.P.1
Goncharov, T.M.2
Goltsev, Y.V.3
Wallach, D.4
-
78
-
-
15844412409
-
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
-
M. Muzio, A.M. Chinnaiyan, F.C. Kischkel, K. O'Rourke, A. Shevchenko, J. Ni, C. Scaffidi, J.D. Bretz, M. Zhang, R. Gentz, M. Mann, P.H. Krammer, M.E. Peter, and V.M. Dixit FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex Cell 85 1996 817 827
-
(1996)
Cell
, vol.85
, pp. 817-827
-
-
Muzio, M.1
Chinnaiyan, A.M.2
Kischkel, F.C.3
O'Rourke, K.4
Shevchenko, A.5
Ni, J.6
Scaffidi, C.7
Bretz, J.D.8
Zhang, M.9
Gentz, R.10
Mann, M.11
Krammer, P.H.12
Peter, M.E.13
Dixit, V.M.14
-
79
-
-
0036056177
-
Acid sphingomyelinase activation requires caspase-8 but not p53 nor reactive oxygen species during Fas-induced apoptosis in human glioma cells
-
M. Sawada, S. Nakashima, T. Kiyono, J. Yamada, S. Hara, M. Nakagawa, J. Shinoda, and N. Sakai Acid sphingomyelinase activation requires caspase-8 but not p53 nor reactive oxygen species during Fas-induced apoptosis in human glioma cells Exp. Cell Res. 273 2002 157 168
-
(2002)
Exp. Cell Res.
, vol.273
, pp. 157-168
-
-
Sawada, M.1
Nakashima, S.2
Kiyono, T.3
Yamada, J.4
Hara, S.5
Nakagawa, M.6
Shinoda, J.7
Sakai, N.8
-
80
-
-
0034708455
-
CD95(Fas/APO-1) signals ceramide generation independent of the effector stage of apoptosis
-
C. Grullich, M.C. Sullards, Z. Fuks, A.H. Merrill Jr., and R. Kolesnick CD95(Fas/APO-1) signals ceramide generation independent of the effector stage of apoptosis J. Biol. Chem. 275 2000 8650 8656
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8650-8656
-
-
Grullich, C.1
Sullards, M.C.2
Fuks, Z.3
Merrill Jr., A.H.4
Kolesnick, R.5
-
81
-
-
0032489554
-
TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase
-
R. Schwandner, K. Wiegmann, K. Bernardo, D. Kreder, and M. Kronke TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase J. Biol. Chem. 273 1998 5916 5922
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5916-5922
-
-
Schwandner, R.1
Wiegmann, K.2
Bernardo, K.3
Kreder, D.4
Kronke, M.5
-
82
-
-
0035093880
-
Phosphoinositide 3-kinase regulates crosstalk between Trk a tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways
-
T.R. Bilderback, V.R. Gazula, and R.T. Dobrowsky Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways J. Neurochem. 76 2001 1540 1551
-
(2001)
J. Neurochem.
, vol.76
, pp. 1540-1551
-
-
Bilderback, T.R.1
Gazula, V.R.2
Dobrowsky, R.T.3
-
83
-
-
17544390315
-
Phosphatidylinositol-3,5-Bisphosphate is a potent and selective inhibitor of acid sphingomyelinase
-
M. Kolzer, C. Arenz, K. Ferlinz, N. Werth, H. Schulze, R. Klingenstein, and K. Sandhoff Phosphatidylinositol-3,5-Bisphosphate is a potent and selective inhibitor of acid sphingomyelinase Biol. Chem. 384 2003 1293 1298
-
(2003)
Biol. Chem.
, vol.384
, pp. 1293-1298
-
-
Kolzer, M.1
Arenz, C.2
Ferlinz, K.3
Werth, N.4
Schulze, H.5
Klingenstein, R.6
Sandhoff, K.7
-
84
-
-
2042499658
-
Acid sphingomyelinase and inhibition by phosphate ion: Role of inhibition by phosphatidyl-myo-inositol 3,4,5-triphosphate in oligodendrocyte cell signaling
-
F.D. Testai, M.A. Landek, R. Goswami, M. Ahmed, and G. Dawson Acid sphingomyelinase and inhibition by phosphate ion: role of inhibition by phosphatidyl-myo-inositol 3,4,5-triphosphate in oligodendrocyte cell signaling J. Neurochem. 89 2004 636 644
-
(2004)
J. Neurochem.
, vol.89
, pp. 636-644
-
-
Testai, F.D.1
Landek, M.A.2
Goswami, R.3
Ahmed, M.4
Dawson, G.5
-
85
-
-
0042858520
-
Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteine
-
H. Qiu, T. Edmunds, J. Baker-Malcolm, K.P. Karey, S. Estes, C. Schwarz, H. Hughes, and S.M. Van Patten Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteine J. Biol. Chem. 278 2003 32744 32752
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 32744-32752
-
-
Qiu, H.1
Edmunds, T.2
Baker-Malcolm, J.3
Karey, K.P.4
Estes, S.5
Schwarz, C.6
Hughes, H.7
Van Patten, S.M.8
-
86
-
-
0021055866
-
The active site of lysosomal sphingomyelinase: Evidence for the involvement of hydrophobic and ionic groups
-
J.W. Callahan, C.S. Jones, D.J. Davidson, and P. Shankaran The active site of lysosomal sphingomyelinase: evidence for the involvement of hydrophobic and ionic groups J. Neurosci. Res. 10 1983 151 163
-
(1983)
J. Neurosci. Res.
, vol.10
, pp. 151-163
-
-
Callahan, J.W.1
Jones, C.S.2
Davidson, D.J.3
Shankaran, P.4
-
87
-
-
0032579258
-
Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. Implications for atherosclerotic lesion development
-
S.L. Schissel, X. Jiang, J. Tweedie-Hardman, T. Jeong, E.H. Camejo, J. Najib, J.H. Rapp, K.J. Williams, and I. Tabas Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. Implications for atherosclerotic lesion development J. Biol. Chem. 273 1998 2738 2746
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 2738-2746
-
-
Schissel, S.L.1
Jiang, X.2
Tweedie-Hardman, J.3
Jeong, T.4
Camejo, E.H.5
Najib, J.6
Rapp, J.H.7
Williams, K.J.8
Tabas, I.9
-
88
-
-
2542473164
-
Cholesterol modulation of sphingomyelinase activity at physiological temperatures
-
F.X. Contreras, J. Sot, M.B. Ruiz-Arguello, A. Alonso, and F.M. Goni Cholesterol modulation of sphingomyelinase activity at physiological temperatures Chem. Phys. Lipids 130 2004 127 134
-
(2004)
Chem. Phys. Lipids
, vol.130
, pp. 127-134
-
-
Contreras, F.X.1
Sot, J.2
Ruiz-Arguello, M.B.3
Alonso, A.4
Goni, F.M.5
-
89
-
-
0029620212
-
Selective activation of c-Jun kinase mitogen-activated protein kinase by CD40 on human B cells
-
N. Sakata, H.R. Patel, N. Terada, A. Aruffo, G.L. Johnson, and E.W. Gelfand Selective activation of c-Jun kinase mitogen-activated protein kinase by CD40 on human B cells J. Biol. Chem. 270 1995 30823 30828
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 30823-30828
-
-
Sakata, N.1
Patel, H.R.2
Terada, N.3
Aruffo, A.4
Johnson, G.L.5
Gelfand, E.W.6
-
90
-
-
0030265656
-
Activation of the Ras signaling pathway by the CD40 receptor
-
E. Gulbins, B. Brenner, K. Schlottmann, U. Koppenhoefer, O. Linderkamp, K.M. Coggeshall, and F. Lang Activation of the Ras signaling pathway by the CD40 receptor J. Immunol. 157 1996 2844 2850
-
(1996)
J. Immunol.
, vol.157
, pp. 2844-2850
-
-
Gulbins, E.1
Brenner, B.2
Schlottmann, K.3
Koppenhoefer, U.4
Linderkamp, O.5
Coggeshall, K.M.6
Lang, F.7
-
92
-
-
0343742670
-
Kinase suppressor of Ras is ceramide-activated protein kinase
-
Y. Zhang, B. Yao, S. Delikat, S. Bayoumy, X.H. Lin, S. Basu, M. McGinley, P.Y. Chan-Hui, H. Lichenstein, and R. Kolesnick Kinase suppressor of Ras is ceramide-activated protein kinase Cell 89 1997 63 72
-
(1997)
Cell
, vol.89
, pp. 63-72
-
-
Zhang, Y.1
Yao, B.2
Delikat, S.3
Bayoumy, S.4
Lin, X.H.5
Basu, S.6
McGinley, M.7
Chan-Hui, P.Y.8
Lichenstein, H.9
Kolesnick, R.10
-
93
-
-
0027428283
-
Ceramide-activated protein phosphatase: Partial purification and relationship to protein phosphatase 2A
-
R.T. Dobrowsky, and Y.A. Hannun Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A Adv. Lipid Res. 25 1993 91 104
-
(1993)
Adv. Lipid Res.
, vol.25
, pp. 91-104
-
-
Dobrowsky, R.T.1
Hannun, Y.A.2
-
94
-
-
0029003788
-
PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid
-
G. Muller, M. Ayoub, P. Storz, J. Rennecke, D. Fabbro, and K. Pfizenmaier PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid EMBO J. 14 1995 1961 1969
-
(1995)
EMBO J.
, vol.14
, pp. 1961-1969
-
-
Muller, G.1
Ayoub, M.2
Storz, P.3
Rennecke, J.4
Fabbro, D.5
Pfizenmaier, K.6
-
95
-
-
0028838235
-
Phosphorylation of Raf by ceramide-activated protein kinase
-
B. Yao, Y. Zhang, S. Delikat, S. Mathias, S. Basu, and R. Kolesnick Phosphorylation of Raf by ceramide-activated protein kinase Nature 378 1995 307 310
-
(1995)
Nature
, vol.378
, pp. 307-310
-
-
Yao, B.1
Zhang, Y.2
Delikat, S.3
Mathias, S.4
Basu, S.5
Kolesnick, R.6
-
96
-
-
0033214095
-
Cathepsin D targeted by acid sphingomyelinase-derived ceramide
-
M. Heinrich, M. Wickel, W. Schneider-Brachert, C. Sandberg, J. Gahr, R. Schwandner, T. Weber, P. Saftig, C. Peters, J. Brunner, M. Kronke, and S. Schutze Cathepsin D targeted by acid sphingomyelinase-derived ceramide EMBO J. 18 1999 5252 5263
-
(1999)
EMBO J.
, vol.18
, pp. 5252-5263
-
-
Heinrich, M.1
Wickel, M.2
Schneider-Brachert, W.3
Sandberg, C.4
Gahr, J.5
Schwandner, R.6
Weber, T.7
Saftig, P.8
Peters, C.9
Brunner, J.10
Kronke, M.11
Schutze, S.12
-
97
-
-
4444341939
-
Compartmentalization of TNF receptor 1 signaling: Internalized TNF receptosomes as death signaling vesicles
-
W. Schneider-Brachert, V. Tchikov, J. Neumeyer, M. Jakob, S. Winoto-Morbach, J. Held-Feindt, M. Heinrich, O. Merkel, M. Ehrenschwender, D. Adam, R. Mentlein, D. Kabelitz, and S. Schutze Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles Immunity 21 2004 415 428
-
(2004)
Immunity
, vol.21
, pp. 415-428
-
-
Schneider-Brachert, W.1
Tchikov, V.2
Neumeyer, J.3
Jakob, M.4
Winoto-Morbach, S.5
Held-Feindt, J.6
Heinrich, M.7
Merkel, O.8
Ehrenschwender, M.9
Adam, D.10
Mentlein, R.11
Kabelitz, D.12
Schutze, S.13
-
98
-
-
0029810967
-
+ channel in T lymphocytes upon Fas stimulation
-
+ channel in T lymphocytes upon Fas stimulation J. Biol. Chem. 271 1996 20465 20469
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 20465-20469
-
-
Szabo, I.1
Gulbins, E.2
Apfel, H.3
Zhang, X.4
Barth, P.5
Busch, A.E.6
Schlottmann, K.7
Pongs, O.8
Lang, F.9
-
99
-
-
0030832241
-
Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases
-
E. Gulbins, I. Szabo, K. Baltzer, and F. Lang Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases Proc. Natl. Acad. Sci. U. S. A. 94 1997 7661 7666
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 7661-7666
-
-
Gulbins, E.1
Szabo, I.2
Baltzer, K.3
Lang, F.4
-
100
-
-
0033598821
-
Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids
-
A. Lepple-Wienhues, C. Belka, T. Laun, A. Jekle, B. Walter, U. Wieland, M. Welz, L. Heil, J. Kun, G. Busch, M. Weller, M. Bamberg, E. Gulbins, and F. Lang Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids Proc. Natl. Acad. Sci. U. S. A. 96 1999 13795 13800
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 13795-13800
-
-
Lepple-Wienhues, A.1
Belka, C.2
Laun, T.3
Jekle, A.4
Walter, B.5
Wieland, U.6
Welz, M.7
Heil, L.8
Kun, J.9
Busch, G.10
Weller, M.11
Bamberg, M.12
Gulbins, E.13
Lang, F.14
-
101
-
-
22144496067
-
2+ influx
-
2+ influx J. Leukocyte Biol. 78 2005 266 278
-
(2005)
J. Leukocyte Biol.
, vol.78
, pp. 266-278
-
-
Church, L.D.1
Hessler, G.2
Goodall, J.E.3
Rider, D.A.4
Workman, C.J.5
Vignali, D.A.6
Bacon, P.A.7
Gulbins, E.8
Young, S.P.9
-
102
-
-
0034944952
-
Molecular properties and physiological roles of ion channels in the immune system
-
M.D. Cahalan, H. Wulff, and K.G. Chandy Molecular properties and physiological roles of ion channels in the immune system J. Clin. Immunol. 21 2001 235 252
-
(2001)
J. Clin. Immunol.
, vol.21
, pp. 235-252
-
-
Cahalan, M.D.1
Wulff, H.2
Chandy, K.G.3
-
104
-
-
0029916913
-
Tyrosine phosphorylation of the Kv1.3 potassium channel
-
T.C. Holmes, D.A. Fadool, and I.B. Levitan Tyrosine phosphorylation of the Kv1.3 potassium channel J. Neurosci. 16 1996 1581 1590
-
(1996)
J. Neurosci.
, vol.16
, pp. 1581-1590
-
-
Holmes, T.C.1
Fadool, D.A.2
Levitan, I.B.3
-
107
-
-
3042755181
-
Ca influx shutdown in neutrophils induced by Fas (CD95) cross-linking
-
K. Ayub, I. Laffafian, S. Dewitt, and M.B. Hallett Ca influx shutdown in neutrophils induced by Fas (CD95) cross-linking Immunology 112 2004 454 460
-
(2004)
Immunology
, vol.112
, pp. 454-460
-
-
Ayub, K.1
Laffafian, I.2
Dewitt, S.3
Hallett, M.B.4
-
108
-
-
0035199418
-
Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis
-
H. Birbes, S. El Bawab, Y.A. Hannun, and L.M. Obeid Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis FASEB J. 15 2001 2669 2679
-
(2001)
FASEB J.
, vol.15
, pp. 2669-2679
-
-
Birbes, H.1
El Bawab, S.2
Hannun, Y.A.3
Obeid, L.M.4
-
109
-
-
2442711625
-
Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin
-
Q. Dai, J. Liu, J. Chen, D. Durrant, T.M. McIntyre, and R.M. Lee Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin Oncogene 23 2004 3650 3658
-
(2004)
Oncogene
, vol.23
, pp. 3650-3658
-
-
Dai, Q.1
Liu, J.2
Chen, J.3
Durrant, D.4
McIntyre, T.M.5
Lee, R.M.6
-
110
-
-
4544261024
-
Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?
-
C. Bionda, J. Portoukalian, D. Schmitt, C. Rodriguez-Lafrasse, and D. Ardail Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria? Biochem. J. 382 2004 527 533
-
(2004)
Biochem. J.
, vol.382
, pp. 527-533
-
-
Bionda, C.1
Portoukalian, J.2
Schmitt, D.3
Rodriguez-Lafrasse, C.4
Ardail, D.5
-
111
-
-
15944425766
-
A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria
-
H. Birbes, C. Luberto, Y.T. Hsu, S. El Bawab, Y.A. Hannun, and L.M. Obeid A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria Biochem. J. 386 2005 445 451
-
(2005)
Biochem. J.
, vol.386
, pp. 445-451
-
-
Birbes, H.1
Luberto, C.2
Hsu, Y.T.3
El Bawab, S.4
Hannun, Y.A.5
Obeid, L.M.6
-
112
-
-
0042030874
-
The reverse activity of human acid ceramidase
-
N. Okino, X. He, S. Gatt, K. Sandhoff, M. Ito, and E.H. Schuchman The reverse activity of human acid ceramidase J. Biol. Chem. 278 2003 29948 29953
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 29948-29953
-
-
Okino, N.1
He, X.2
Gatt, S.3
Sandhoff, K.4
Ito, M.5
Schuchman, E.H.6
-
113
-
-
0041766297
-
Screening for nitric oxide-dependent protein-protein interactions
-
A. Matsumoto, K.E. Comatas, L. Liu, and J.S. Stamler Screening for nitric oxide-dependent protein-protein interactions Science 301 2003 657 661
-
(2003)
Science
, vol.301
, pp. 657-661
-
-
Matsumoto, A.1
Comatas, K.E.2
Liu, L.3
Stamler, J.S.4
-
114
-
-
0034623715
-
The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosis
-
L.J. Siskind, and M. Colombini The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosis J. Biol. Chem. 275 2000 38640 38644
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 38640-38644
-
-
Siskind, L.J.1
Colombini, M.2
-
115
-
-
0036733578
-
Cholesterol, lipid rafts, and disease
-
K. Simons, and R. Ehehalt Cholesterol, lipid rafts, and disease J. Clin. Invest. 110 2002 597 603
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 597-603
-
-
Simons, K.1
Ehehalt, R.2
-
117
-
-
0033761316
-
CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa
-
H. Grassmé, S. Kirschnek, J. Riethmueller, A. Riehle, G. von Kurthy, F. Lang, M. Weller, and E. Gulbins CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa Science 290 2000 527 530
-
(2000)
Science
, vol.290
, pp. 527-530
-
-
Grassmé, H.1
Kirschnek, S.2
Riethmueller, J.3
Riehle, A.4
Von Kurthy, G.5
Lang, F.6
Weller, M.7
Gulbins, E.8
-
118
-
-
0035086284
-
Pseudomonas aeruginosa-induced apoptosis involves mitochondria and stress-activated protein kinases
-
V. Jendrossek, H. Grassme, I. Mueller, F. Lang, and E. Gulbins Pseudomonas aeruginosa-induced apoptosis involves mitochondria and stress-activated protein kinases Infect. Immun. 69 2001 2675 2683
-
(2001)
Infect. Immun.
, vol.69
, pp. 2675-2683
-
-
Jendrossek, V.1
Grassme, H.2
Mueller, I.3
Lang, F.4
Gulbins, E.5
-
119
-
-
0041701380
-
Pseudomonas aeruginosa-induced apoptosis is defective in respiratory epithelial cells expressing mutant cystic fibrosis transmembrane conductance regulator
-
C.L. Cannon, M.P. Kowalski, K.S. Stopak, and G.B. Pier Pseudomonas aeruginosa-induced apoptosis is defective in respiratory epithelial cells expressing mutant cystic fibrosis transmembrane conductance regulator Am. J. Respir. Cell Mol. Biol. 29 2003 188 197
-
(2003)
Am. J. Respir. Cell Mol. Biol.
, vol.29
, pp. 188-197
-
-
Cannon, C.L.1
Kowalski, M.P.2
Stopak, K.S.3
Pier, G.B.4
-
120
-
-
0030021470
-
Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections
-
G.B. Pier, M. Grout, T.S. Zaidi, J.C. Olsen, L.G. Johnson, J.R. Yankaskas, and J.B. Goldberg Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections Science 271 1996 64 67
-
(1996)
Science
, vol.271
, pp. 64-67
-
-
Pier, G.B.1
Grout, M.2
Zaidi, T.S.3
Olsen, J.C.4
Johnson, L.G.5
Yankaskas, J.R.6
Goldberg, J.B.7
-
121
-
-
0037076416
-
CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation
-
T.H. Schroeder, M.M. Lee, P.W. Yacono, C.L. Cannon, A.A. Gerceker, D.E. Golan, and G.B. Pier CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation Proc. Natl. Acad. Sci. U. S. A. 99 2002 6907 6912
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 6907-6912
-
-
Schroeder, T.H.1
Lee, M.M.2
Yacono, P.W.3
Cannon, C.L.4
Gerceker, A.A.5
Golan, D.E.6
Pier, G.B.7
-
122
-
-
20244368666
-
Stimulation of erythrocyte ceramide formation by platelet-activating factor
-
P.A. Lang, D.S. Kempe, V. Tanneur, K. Eisele, B.A. Klarl, S. Myssina, V. Jendrossek, S. Ishii, T. Shimizu, M. Waidmann, G. Hessler, S.M. Huber, F. Lang, and T. Wieder Stimulation of erythrocyte ceramide formation by platelet-activating factor J. Cell Sci. 118 2005 1233 1243
-
(2005)
J. Cell Sci.
, vol.118
, pp. 1233-1243
-
-
Lang, P.A.1
Kempe, D.S.2
Tanneur, V.3
Eisele, K.4
Klarl, B.A.5
Myssina, S.6
Jendrossek, V.7
Ishii, S.8
Shimizu, T.9
Waidmann, M.10
Hessler, G.11
Huber, S.M.12
Lang, F.13
Wieder, T.14
-
123
-
-
0042471938
-
Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria
-
E. Anes, M.P. Kuhnel, E. Bos, J. Moniz-Pereira, A. Habermann, and G. Griffiths Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria Nat. Cell Biol. 5 2003 793 802
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 793-802
-
-
Anes, E.1
Kuhnel, M.P.2
Bos, E.3
Moniz-Pereira, J.4
Habermann, A.5
Griffiths, G.6
|