The mitochondrion in apoptosis: How Pandora's box opens

Nature Reviews Molecular Cell Biology

Volumn 2, Issue 1, 2001, Pages 67-71

  Zamzami, Naoufal ^a   Kroemer, Guido ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; ONCOPROTEIN; PORIN; PROTEIN BAX; PROTEIN BCL 2; VOLTAGE DEPENDENT ANION CHANNEL;

ANIMAL; APOPTOSIS; BIOLOGICAL MODEL; INTRACELLULAR MEMBRANE; MITOCHONDRION; PERMEABILITY; PHYSIOLOGY; REVIEW;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; INTRACELLULAR MEMBRANES; MITOCHONDRIA; MITOCHONDRIAL ADP, ATP TRANSLOCASES; MODELS, BIOLOGICAL; PERMEABILITY; PORINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; VOLTAGE-DEPENDENT ANION CHANNELS;

EID: 0035229427     PISSN: 14710072     EISSN: None     Source Type: Journal    
DOI: 10.1038/35048073     Document Type: Article

References (41)

1. Green, D. R. & Reed, J. C. Mitochondria and apoptosis. Science 281, 1309-1312 (1998).
2. Kroemer, G. & Reed, J. C. Mitochondrial control of cell death. Mature Med. 6, 513-519 (2000).
3. Budijardjo, I., Oliver, H., Lutter, M., Luo, X. & Wang, X. Biochemical pathways of caspase activation during apoptosis. Annu. Rev. Cell Dev. Biol. 15, 269-290 (1999).
4. Vander Heiden, M. G. & Thompson, C. B. Bcl-2 proteins: Inhibitors of apoptosis or regulators of mitochondrial homeostasis? Nature Cell Biol. 1, E209-E216 (1999).
5. Gross, A., McDonnell, J. M. & Korsmeyer, S. J. Bcl-2 family members and the mitochondria in apoptosis. Genes Dev. 13, 1899-1911 (1999).
6. Crompton, M. The mitochondrial permeability transition pore and its role in cell death. Biochem. J. 341, 233-249 (1999).
7. Woodfield, K., Ruck, A., Brdiczka, D. & Halestrap, A. P. Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition. Biochem. J. 336, 287-290 (1998).
8. Feldmann, G. et al. Opening of the mitochondrial permeability transition pore causes matrix expansion and outer membrane rupture in Fas-mediated hepatic apoptosis in mice. Hepatology 31, 674-683 (2000).
9. Yin, X.-M. et al. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400, 886-891 (1999).
10. 2+ ions. J. Cell Biol. 143, 217-224 (1998).
11. von Ahsen, O. et al. Preservation of mitochondrial structure and function after Bid-or Bax-mediated cytochrome c release. J. Cell Biol. 150, 1027-1036 (2000).
12. Eskes, R., Desagher, S., Antonsson, B. & Martinou, J. C. Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane. Mol. Cell. Biol. 20, 929-935 (2000).
13. Wei, M. C. et al. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 14, 2060-2071 (2000).
14. Kroemer, G., Dallaporta, B. & Resche-Rigon, M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu. Rev. Physiol. 60, 619-642 (1998).
15. Sullivan, P. G., Thompson, M. B. & Scheff, S. W. Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury. Exp. Neurol. 160, 226-234 (1999).
16. Budd, S. L. Tenneti, L., Lishnak, T. & Lipton, S. A. Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons. Proc. Natl Acad. Sci. USA 97, 6161-6166 (2000).
17. Tafain, M., Schneider, T. G., Pastorino, J. G. & Farber, J. L. Cytochrome c-dependent activation of caspase-3 by tumor necrosis factor requires induction of the mitochondrial permeability transition. Am. J. Pathol. 156, 2111-2121 (2000).
18. Jacotot, E. et al. The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. J. Exp. Med. 191, 33-45 (2000).
19. Goldmacher, V. S. et al. A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2. Proc. Natl Acad. Sci. USA 96, 12536-12541 (1999).
20. Rahmani, Z., Huh, K. W., Lasher, R. & Siddiqui, A. Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential. J. Virol. 74, 2840-2846 (2000).
21. Massari, P., Ho, Y. & Wetzler, L. M. Neisseria meningitidis porin PorB interacts with mitochondria and protects cells from apoptosis. Proc. Natl Acad. Sci. USA 97, 9070-9075 (2000).
22. Shimizu, S., Narita, M. & Tsujimoto, Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399, 483-487 (1999).
23. Marzo, I. et al. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 281, 2027-2031 (1998).
24. Kaukonen, J. et al. Role of adenine nucleotide translocator 1 in mtDNA maintenance. Science 289, 782-785 (2000).
25. Motoyama, S. et al. Bcl-2 is located predominantly in the inner membrane and crista of mitochondria in rat liver. Biochem. Biophys. Res. Commun. 249, 628-636 (1998).
26. Gotow, T. et al. Selective localization of Bcl-2 to the inner mitochondrial and smooth endoplasmic reticulum membranes in mammalian cells. Cell. Death Differ. 7, 666-674 (2000).
27. Costantini, P. et al. Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis. Oncogene 19, 307-314 (2000).
28. Brenner, C. et al. Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator. Oncogene 19, 329-336 (2000).
29. Shimizu, S., Ide, T., Yanagida, T. & Tsujimoti, Y. Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c. J. Biol. Chem. 275, 12321-12325 (2000).
30. Shimizu, S., Konishi, A., Kodama, T. & Tsujimoto, Y. BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death. Proc. Natl Acad. Sci. USA 97, 3100-3105 (2000).
31. Jürgensmeier, J. M. et al. Bax directly induces release of cytochrome c from isolated mitochondria. Proc. Natl Acad. Sci. USA 95, 4997-5002 (1998).
32. Narita, M. et al. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc. Natl Acad. Sci. USA 95, 14681-14686 (1998).
33. Pastorino, J. G. et al. Functional consequences of sustained or transient activation by Bax of the mitochondrial permeability transition pore. J. Biol. Chem. 274, 31734-31739 (1999).
34. Vande Velde, C. et al. BIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol. Cell. Biol. 20, 5454-5463 (2000).
35. Harris, M. H., Vander Heiden, M. G., Krön, S. J. & Thompson, C. B. Role of oxidative phosphorylation in Bax toxicity. Mol. Cell. Biol. 20, 3590-3596 (2000).
36. 1-ATPase proton pump is required for function of proapoptotic protein Bax in yeast and mammalian cells. Mol. Cell 1, 327-336 (1998).
37. L, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations. Proc. Natl Acad. Sci. USA 96, 5492-5497 (1999).
38. Kudla, G. et al. Thedestabilizationoflipid membrane induced by the C-terminal fragment of caspase 8-cleaved Bid is inhibited by the N-terminal fragment. J. Biol. Chem. 275, 22713-22718 (2000).
39. Schendel, S. L. et al. Ion channel activity of the BH3 only bcl-2 family member, BID. J. Biol. Chem. 274, 21932-21936 (1999).
40. Saito, M., Korsmeyer, S. J. & Schlesinger, P. H. Bax-dependent transport of cytochrome c reconstituted in pure liposomes. Nature Cell Biol. 2, 553-555 (2000).
41. Shimizu, S. & Tsujimoto, Y. Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity. Proc. Natl Acad. Sci. USA 97, 577-582 (2000).