메뉴 건너뛰기




Volumn 85, Issue 2, 2014, Pages 265-275

Kidney xenotransplantation

Author keywords

genetically modified; immunosuppression; pig to primate model; tolerance; transgenesis; xenotransplantation

Indexed keywords

ALEMTUZUMAB; ALPHA 1,3 GALACTOSYLTRANSFERASE; IMMUNOGLOBULIN G; RITUXIMAB; THROMBOMODULIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

EID: 84895907263     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2013.381     Document Type: Review
Times cited : (42)

References (163)
  • 1
    • 84867074863 scopus 로고    scopus 로고
    • The AJT Report: News and issues that affect organ and tissue transplantation
    • Pondrom S. The AJT Report: News and issues that affect organ and tissue transplantation. Am J Transplant 2012; 12: 2565-2566
    • (2012) Am J Transplant , vol.12 , pp. 2565-2566
    • Pondrom, S.1
  • 2
    • 84859832594 scopus 로고    scopus 로고
    • A brief history of cross-species organ transplantation
    • Cooper. DKC. A brief history of cross-species organ transplantation. Proc (Bayl Univ Med Cent) 2012; 25: 49-57
    • (2012) Proc (Bayl Univ Med Cent , vol.25 , pp. 49-57
    • Cooper, D.K.C.1
  • 3
    • 0031668230 scopus 로고    scopus 로고
    • Extracorporeal (ex vivo') connection of pig kidneys to humans III. Studies of plasma complement activation and complement deposition in the kidney tissue
    • Bengtsson A, Svalander CT, Molne J et al. Extracorporeal (ex vivo') connection of pig kidneys to humans. III. Studies of plasma complement activation and complement deposition in the kidney tissue. Xenotransplantation 1998; 5: 176-183
    • (1998) Xenotransplantation , vol.5 , pp. 176-183
    • Bengtsson, A.1    Svalander, C.T.2    Molne, J.3
  • 4
    • 84857233943 scopus 로고    scopus 로고
    • Clinical xenotransplantation: The next medical revolution
    • Ekser B, Ezzelarab M, Hara H et al. Clinical xenotransplantation: The next medical revolution? Lancet 2012; 379: 672-683
    • (2012) Lancet , vol.379 , pp. 672-683
    • Ekser, B.1    Ezzelarab, M.2    Hara, H.3
  • 5
    • 13444269248 scopus 로고    scopus 로고
    • Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
    • Yamada K, Yazawa K, Shimizu A et al. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med 2005; 11: 32-34
    • (2005) Nat Med , vol.11 , pp. 32-34
    • Yamada, K.1    Yazawa, K.2    Shimizu, A.3
  • 6
    • 0034661964 scopus 로고    scopus 로고
    • Long-Term survival of nonhuman primates receiving life-supporting transgenic porcine kidney xenografts
    • Cozzi E, Bhatti F, Schmoeckel M et al. Long-Term survival of nonhuman primates receiving life-supporting transgenic porcine kidney xenografts. Transplantation 2000; 70: 15-21
    • (2000) Transplantation , vol.70 , pp. 15-21
    • Cozzi, E.1    Bhatti, F.2    Schmoeckel, M.3
  • 7
    • 72449190098 scopus 로고    scopus 로고
    • Results of gal-knockout porcine thymokidney xenografts
    • Griesemer AD, Hirakata A, Shimizu A et al. Results of gal-knockout porcine thymokidney xenografts. Am J Transplant 2009; 9: 2669-2678
    • (2009) Am J Transplant , vol.9 , pp. 2669-2678
    • Griesemer, A.D.1    Hirakata, A.2    Shimizu, A.3
  • 8
    • 11144355681 scopus 로고    scopus 로고
    • Ureteral stenosis in HDAF pig-To-primate renal xenotransplantation a phenomenon related to immunological events
    • Baldan N, Rigotti P, Calabrese F et al. Ureteral stenosis in HDAF pig-To-primate renal xenotransplantation: A phenomenon related to immunological events? Am J Transplant 2004; 4: 475-481
    • (2004) Am j transplant , vol.4 , pp. 475-481
    • Baldan, N.1    Rigotti, P.2    Calabrese, F.3
  • 9
    • 0142246147 scopus 로고    scopus 로고
    • Pig kidney transplantation in baboons treated intravenously with a bovine serum albumin-Galalpha1-3Gal conjugate
    • Gollackner B, Knosalla C, Houser S et al. Pig kidney transplantation in baboons treated intravenously with a bovine serum albumin-Galalpha1-3Gal conjugate. Xenotransplantation 2003; 10: 606-614
    • (2003) Xenotransplantation , vol.10 , pp. 606-614
    • Gollackner, B.1    Knosalla, C.2    Houser, S.3
  • 10
    • 28644446730 scopus 로고    scopus 로고
    • Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys
    • Chen G, Qian H, Starzl T et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med 2005; 11: 1295-1298
    • (2005) Nat Med , vol.11 , pp. 1295-1298
    • Chen, G.1    Qian, H.2    Starzl, T.3
  • 11
    • 33644862221 scopus 로고    scopus 로고
    • The role of anti-non-Gal antibodies in the development of acute humoral xenograft rejection of hDAF transgenic porcine kidneys in baboons receiving anti-Gal antibody neutralization therapy
    • Chen G, Sun H, Yang H et al. The role of anti-non-Gal antibodies in the development of acute humoral xenograft rejection of hDAF transgenic porcine kidneys in baboons receiving anti-Gal antibody neutralization therapy. Transplantation 2006; 81: 273-283
    • (2006) Transplantation , vol.81 , pp. 273-283
    • Chen, G.1    Sun, H.2    Yang, H.3
  • 12
    • 33750095969 scopus 로고    scopus 로고
    • Selected physiologic compatibilities and incompatibilities between human and porcine organ systems
    • Ibrahim Z, Busch J, Awwad M et al. Selected physiologic compatibilities and incompatibilities between human and porcine organ systems. Xenotransplantation 2006; 13: 488-499
    • (2006) Xenotransplantation , vol.13 , pp. 488-499
    • Ibrahim, Z.1    Busch, J.2    Awwad, M.3
  • 13
    • 0034785608 scopus 로고    scopus 로고
    • Physiological aspects of pig-To-primate renal xenotransplantation
    • Soin B, Smith KG, Zaidi A et al. Physiological aspects of pig-To-primate renal xenotransplantation. Kidney Int 2001; 60: 1592-1597
    • (2001) Kidney Int , vol.60 , pp. 1592-1597
    • Soin, B.1    Smith, K.G.2    Zaidi, A.3
  • 14
    • 0024297335 scopus 로고
    • Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells
    • Galili U, Shohet SB, Kobrin E et al. Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells. J Biol Chem 1988; 263: 17755-17762
    • (1988) J Biol Chem , vol.263 , pp. 17755-17762
    • Galili, U.1    Shohet, S.B.2    Kobrin, E.3
  • 15
    • 38749117878 scopus 로고    scopus 로고
    • The Galalpha1,3Galbeta1,4GlcNAc-R (alpha-Gal) epitope: A carbohydrate of unique evolution and clinical relevance
    • Macher BA, Galili U. The Galalpha1,3Galbeta1,4GlcNAc-R (alpha-Gal) epitope: A carbohydrate of unique evolution and clinical relevance. Biochim Biophys Acta 2008; 1780: 75-88
    • (2008) Biochim Biophys Acta , vol.1780 , pp. 75-88
    • Macher, B.A.1    Galili, U.2
  • 16
    • 77957165258 scopus 로고    scopus 로고
    • Reference values for thromboelastometry (ROTEM(R) in cynomolgus monkeys (Macaca fascicularis)
    • Spiezia L, Bertini D, Boldrin M et al. Reference values for thromboelastometry (ROTEM(R)) in cynomolgus monkeys (Macaca fascicularis). Thromb Res 2010; 126: E294-e297
    • (2010) Thromb Res , vol.126
    • Spiezia, L.1    Bertini, D.2    Boldrin, M.3
  • 17
    • 2442538314 scopus 로고    scopus 로고
    • Are N-glycolylneuraminic acid (Hanganutziu-Deicher antigens important in pig-To-human xenotransplantation
    • Miwa Y, Kobayashi T, Nagasaka T et al. Are N-glycolylneuraminic acid (Hanganutziu-Deicher) antigens important in pig-To-human xenotransplantation? Xenotransplantation 2004; 11: 247-253
    • (2004) Xenotransplantation , vol.11 , pp. 247-253
    • Miwa, Y.1    Kobayashi, T.2    Nagasaka, T.3
  • 18
    • 77955368995 scopus 로고    scopus 로고
    • Novel mechanism for the generation of human xeno-Autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid
    • Taylor RE, Gregg CJ, Padler-Karavani V et al. Novel mechanism for the generation of human xeno-Autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid. J Exp Med 2010; 207: 1637-1646
    • (2010) J Exp Med , vol.207 , pp. 1637-1646
    • Taylor, R.E.1    Gregg, C.J.2    Padler-Karavani, V.3
  • 19
    • 0025264624 scopus 로고
    • Frameshift and nonsense mutations in a human genomic sequence homologous to a murine UDP-Gal:beta-D-Gal(1, 4)-D-GlcNAc alpha(1,3)-galactosyltransferase cDNA
    • Larsen RD, Rivera-Marrero CA, Ernst LK et al. Frameshift and nonsense mutations in a human genomic sequence homologous to a murine UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase cDNA. J Biol Chem 1990; 265: 7055-7061
    • (1990) J Biol Chem , vol.265 , pp. 7055-7061
    • Larsen, R.D.1    Rivera-Marrero, C.A.2    Ernst, L.K.3
  • 20
    • 84859416185 scopus 로고    scopus 로고
    • Multifarious roles of sialic acids in immunity
    • Varki A, Gagneux P. Multifarious roles of sialic acids in immunity. Ann NY Acad Sci 2012; 1253: 16-36
    • (2012) Ann NY Acad Sci , vol.1253 , pp. 16-36
    • Varki, A.1    Gagneux, P.2
  • 21
    • 0023950850 scopus 로고
    • Interaction between human natural anti-Alpha-galactosyl immunoglobulin G and bacteria of the human flora
    • Galili U, Mandrell RE, Hamadeh RM et al. Interaction between human natural anti-Alpha-galactosyl immunoglobulin G and bacteria of the human flora. Infect Immun 1988; 56: 1730-1737
    • (1988) Infect Immun , vol.56 , pp. 1730-1737
    • Galili, U.1    Mandrell, R.E.2    Hamadeh, R.M.3
  • 22
    • 0027944492 scopus 로고
    • Characterization and affinity isolation of xenoreactive human natural antibodies
    • Parker W, Bruno D, Holzknecht ZE et al. Characterization and affinity isolation of xenoreactive human natural antibodies. J Immunol 1994; 153: 3791-3803
    • (1994) J Immunol , vol.153 , pp. 3791-3803
    • Parker, W.1    Bruno, D.2    Holzknecht, Z.E.3
  • 23
    • 0021678856 scopus 로고
    • A unique natural human IgG antibody with anti-Alpha-galactosyl specificity
    • Galili U, Rachmilewitz EA, Peleg A et al. A unique natural human IgG antibody with anti-Alpha-galactosyl specificity. J Exp Med 1984; 160: 1519-1531
    • (1984) J Exp Med , vol.160 , pp. 1519-1531
    • Galili, U.1    Rachmilewitz, E.A.2    Peleg, A.3
  • 24
    • 33746467974 scopus 로고    scopus 로고
    • Pathology of renal xenograft rejection in pig to non-human primate transplantation
    • Shimizu A, Yamada K. Pathology of renal xenograft rejection in pig to non-human primate transplantation. Clin Transplant 2006; 20(Suppl 15): 46-52
    • (2006) Clin Transplant , vol.20 , Issue.SUPPL. 15 , pp. 46-52
    • Shimizu, A.1    Yamada, K.2
  • 25
    • 18544404547 scopus 로고    scopus 로고
    • Renal xenografts from tripletransgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons
    • Cowan PJ, Aminian A, Barlow H et al. Renal xenografts from tripletransgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons. Transplantation 2000; 69: 2504-2515
    • (2000) Transplantation , vol.69 , pp. 2504-2515
    • Cowan, P.J.1    Aminian, A.2    Barlow, H.3
  • 26
    • 0032570299 scopus 로고    scopus 로고
    • Removal of anti-porcine natural antibodies from human and nonhuman primate plasma in vitro and in vivo by a Galalpha1-3Galbeta1-4betaGlc-X immunoaffinity column
    • Xu Y, Lorf T, Sablinski T et al. Removal of anti-porcine natural antibodies from human and nonhuman primate plasma in vitro and in vivo by a Galalpha1-3Galbeta1-4betaGlc-X immunoaffinity column. Transplantation 1998; 65: 172-179
    • (1998) Transplantation , vol.65 , pp. 172-179
    • Xu, Y.1    Lorf, T.2    Sablinski, T.3
  • 27
    • 62849083659 scopus 로고    scopus 로고
    • Gal KO pig renal xenografts are not hyperacutely rejected by non-immunosuppressed baboons
    • Cowan PJ, Salvaris EJ, Crikis S et al. Gal KO pig renal xenografts are not hyperacutely rejected by non-immunosuppressed baboons. Am J Transplant 2006; 6: 1050
    • (2006) Am J Transplant , vol.6 , pp. 1050
    • Cowan, P.J.1    Salvaris, E.J.2    Crikis, S.3
  • 28
    • 34547643527 scopus 로고    scopus 로고
    • Characterization of natural human anti-non-gal antibodies and their effect on activation of porcine gal-deficient endothelial cells
    • Saethre M, Baumann BC, Fung M et al. Characterization of natural human anti-non-gal antibodies and their effect on activation of porcine gal-deficient endothelial cells. Transplantation 2007; 84: 244-250
    • (2007) Transplantation , vol.84 , pp. 244-250
    • Saethre, M.1    Baumann, B.C.2    Fung, M.3
  • 29
    • 33846590924 scopus 로고    scopus 로고
    • Reactivity of human natural antibodies to endothelial cells from Galalpha(1, 3)Gal-deficient pigs
    • Baumann BC, Stussi G, Huggel K et al. Reactivity of human natural antibodies to endothelial cells from Galalpha(1,3)Gal-deficient pigs. Transplantation 2007; 83: 193-201
    • (2007) Transplantation , vol.83 , pp. 193-201
    • Baumann, B.C.1    Stussi, G.2    Huggel, K.3
  • 31
    • 0033574673 scopus 로고    scopus 로고
    • Target cell susceptibility to lysis by human natural killer cells is augmented by alpha(1,rfis1 3)-galactosyltransferase and reduced by alpha(1, 2)-fucosyltransferase
    • Artrip JH, Kwiatkowski P, Michler RE et al. Target cell susceptibility to lysis by human natural killer cells is augmented by alpha(1,3)- galactosyltransferase and reduced by alpha(1, 2)-fucosyltransferase. J Biol Chem 1999; 274: 10717-10722
    • (1999) J Biol Chem , vol.274 , pp. 10717-10722
    • Artrip, J.H.1    Kwiatkowski, P.2    Michler, R.E.3
  • 32
    • 33745842254 scopus 로고    scopus 로고
    • Human monocytes recognize porcine endothelium via the interaction of galectin 3 and alpha-GAL
    • Jin R, Greenwald A, Peterson MD et al. Human monocytes recognize porcine endothelium via the interaction of galectin 3 and alpha-GAL. J Immunol 2006; 177: 1289-1295
    • (2006) J Immunol , vol.177 , pp. 1289-1295
    • Jin, R.1    Greenwald, A.2    Peterson, M.D.3
  • 33
    • 0036766494 scopus 로고    scopus 로고
    • Xenogeneic human NK cytotoxicity against porcine endothelial cells is perforin/granzyme B dependent and not inhibited by Bcl-2 overexpression
    • Matter-Reissmann UB, Forte P, Schneider MK et al. Xenogeneic human NK cytotoxicity against porcine endothelial cells is perforin/granzyme B dependent and not inhibited by Bcl-2 overexpression. Xenotransplantation 2002; 9: 325-337
    • (2002) Xenotransplantation , vol.9 , pp. 325-337
    • Matter-Reissmann, U.B.1    Forte, P.2    Schneider, M.K.3
  • 34
    • 67349171077 scopus 로고    scopus 로고
    • Xenotransplantation: Role of natural immunity
    • Li S, Waer M, Billiau AD. Xenotransplantation: Role of natural immunity. Transpl Immunol. 2009; 21: 70-74
    • (2009) Transpl Immunol , vol.21 , pp. 70-74
    • Li, S.1    Waer, M.2    Billiau, A.D.3
  • 35
    • 0031225484 scopus 로고    scopus 로고
    • Analysis of polymorphism in porcine MHC class I genes: Alterations in signals recognized by human cytotoxic lymphocytes
    • Sullivan JA, Oettinger HF, Sachs DH et al. Analysis of polymorphism in porcine MHC class I genes: Alterations in signals recognized by human cytotoxic lymphocytes. J Immunol 1997; 159: 2318-2326
    • (1997) J Immunol , vol.159 , pp. 2318-2326
    • Sullivan, J.A.1    Oettinger, H.F.2    Sachs, D.H.3
  • 36
    • 33644809537 scopus 로고    scopus 로고
    • Species-And cell typespecific interactions between CD47 and human SIRPalpha
    • Subramanian S, Parthasarathy R, Sen S et al. Species-And cell typespecific interactions between CD47 and human SIRPalpha. Blood 2006; 107: 2548-2556
    • (2006) Blood , vol.107 , pp. 2548-2556
    • Subramanian, S.1    Parthasarathy, R.2    Sen, S.3
  • 37
    • 34247568865 scopus 로고    scopus 로고
    • Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages
    • Ide K, Wang H, Tahara H et al. Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages. Proc Natl Acad Sci USA 2007; 104: 5062-5066
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5062-5066
    • Ide, K.1    Wang, H.2    Tahara, H.3
  • 39
    • 33644810480 scopus 로고    scopus 로고
    • Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-Transgenic swineto-baboon kidney xenografts
    • Shimizu A, Yamada K, Yamamoto S et al. Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-Transgenic swineto-baboon kidney xenografts. J Am Soc Nephrol 2005; 16: 2732-2745
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2732-2745
    • Shimizu, A.1    Yamada, K.2    Yamamoto, S.3
  • 40
    • 84856944798 scopus 로고    scopus 로고
    • Pathologic characteristics of transplanted kidney xenografts
    • Shimizu A, Yamada K, Robson SC et al. Pathologic characteristics of transplanted kidney xenografts. J Am Soc Nephrol 2012; 23: 225-235
    • (2012) J Am Soc Nephrol , vol.23 , pp. 225-235
    • Shimizu, A.1    Yamada, K.2    Robson, S.C.3
  • 41
    • 4344688865 scopus 로고    scopus 로고
    • Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons
    • Houser SL, Kuwaki K, Knosalla C et al. Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons. Xenotransplantation 2004; 11: 416-425
    • (2004) Xenotransplantation , vol.11 , pp. 416-425
    • Houser, S.L.1    Kuwaki, K.2    Knosalla, C.3
  • 42
    • 65549162661 scopus 로고    scopus 로고
    • The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients
    • Ezzelarab M, Garcia B, Azimzadeh A et al. The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients. Transplantation 2009; 87: 805-812
    • (2009) Transplantation , vol.87 , pp. 805-812
    • Ezzelarab, M.1    Garcia, B.2    Azimzadeh, A.3
  • 43
    • 0032535196 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation in association with the delayed rejection of pig-To-baboon renal xenografts
    • Ierino FL, Kozlowski T, Siegel JB et al. Disseminated intravascular coagulation in association with the delayed rejection of pig-To-baboon renal xenografts. Transplantation 1998; 66: 1439-1450
    • (1998) Transplantation , vol.66 , pp. 1439-1450
    • Ierino, F.L.1    Kozlowski, T.2    Siegel, J.B.3
  • 44
    • 0034669536 scopus 로고    scopus 로고
    • Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates
    • Buhler L, Basker M, Alwayn IP et al. Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates. Transplantation 2000; 70: 1323-1331
    • (2000) Transplantation , vol.70 , pp. 1323-1331
    • Buhler, L.1    Basker, M.2    Alwayn, I.P.3
  • 45
    • 10744227204 scopus 로고    scopus 로고
    • Alterations in the coagulation profile in renal pig-To-monkey xenotransplantation
    • Cozzi E, Simioni P, Boldrin M et al. Alterations in the coagulation profile in renal pig-To-monkey xenotransplantation. Am J Transplant 2004; 4: 335-345
    • (2004) Am J Transplant , vol.4 , pp. 335-345
    • Cozzi, E.1    Simioni, P.2    Boldrin, M.3
  • 46
    • 77954079584 scopus 로고    scopus 로고
    • Recipient tissue factor expression is associated with consumptive coagulopathy in pig-To-primate kidney xenotransplantation
    • Lin CC, Ezzelarab M, Shapiro R et al. Recipient tissue factor expression is associated with consumptive coagulopathy in pig-To-primate kidney xenotransplantation. Am J Transplant 2010; 10: 1556-1568
    • (2010) Am J Transplant , vol.10 , pp. 1556-1568
    • Lin, C.C.1    Ezzelarab, M.2    Shapiro, R.3
  • 47
    • 0028938634 scopus 로고
    • Transient perturbation of endothelial integrity induced by natural antibodies and complement
    • Saadi S, Platt JL. Transient perturbation of endothelial integrity induced by natural antibodies and complement. J Exp Med 1995; 181: 21-31
    • (1995) J Exp Med , vol.181 , pp. 21-31
    • Saadi, S.1    Platt, J.L.2
  • 48
    • 0031906452 scopus 로고    scopus 로고
    • Tyrosine phosphorylation following lectin mediated endothelial cell stimulation
    • Palmetshofer A, Robson SC, Bach FH. Tyrosine phosphorylation following lectin mediated endothelial cell stimulation. Xenotransplantation 1998; 5: 61-66
    • (1998) Xenotransplantation , vol.5 , pp. 61-66
    • Palmetshofer, A.1    Robson, S.C.2    Bach, F.H.3
  • 49
    • 0032522737 scopus 로고    scopus 로고
    • Alpha-galactosyl epitopemediated activation of porcine aortic endothelial cells: Type II activation
    • Palmetshofer A, Galili U, Dalmasso AP et al. Alpha-galactosyl epitopemediated activation of porcine aortic endothelial cells: Type II activation. Transplantation 1998; 65: 971-978
    • (1998) Transplantation , vol.65 , pp. 971-978
    • Palmetshofer, A.1    Galili, U.2    Dalmasso, A.P.3
  • 50
    • 2942661758 scopus 로고    scopus 로고
    • Acute vascular rejection of xenografts: Roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity
    • Gollackner B, Goh SK, Qawi I et al. Acute vascular rejection of xenografts: Roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity. Transplantation 2004; 77: 1735-1741
    • (2004) Transplantation , vol.77 , pp. 1735-1741
    • Gollackner, B.1    Goh, S.K.2    Qawi, I.3
  • 51
    • 53449098952 scopus 로고    scopus 로고
    • Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells
    • Lin CC, Chen D, McVey JH et al. Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells. Transplantation 2008; 86: 702-709
    • (2008) Transplantation , vol.86 , pp. 702-709
    • Lin, C.C.1    Chen, D.2    McVey, J.H.3
  • 52
    • 84881316905 scopus 로고    scopus 로고
    • Human platelets do not express tissue factor
    • Osterud B, Olsen JO. Human platelets do not express tissue factor. Thromb Res 2013; 132: 112-115
    • (2013) Thromb Res , vol.132 , pp. 112-115
    • Osterud, B.1    Olsen, J.O.2
  • 53
    • 2142820093 scopus 로고    scopus 로고
    • Endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejection
    • Ghanekar A, Mendicino M, Liu H et al. Endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejection. J Immunol 2004; 172: 5693-5701
    • (2004) J Immunol , vol.172 , pp. 5693-5701
    • Ghanekar, A.1    Mendicino, M.2    Liu, H.3
  • 54
    • 76349087621 scopus 로고    scopus 로고
    • Potential value of human thrombomodulin and DAF expression for coagulation control in pig-Tohuman xenotransplantation
    • Miwa Y, Yamamoto K, Onishi A et al. Potential value of human thrombomodulin and DAF expression for coagulation control in pig-Tohuman xenotransplantation. Xenotransplantation 2010; 17: 26-37
    • (2010) Xenotransplantation , vol.17 , pp. 26-37
    • Miwa, Y.1    Yamamoto, K.2    Onishi, A.3
  • 55
    • 79951807624 scopus 로고    scopus 로고
    • The link between vascular features and thrombosis
    • Esmon CT, Esmon NL. The link between vascular features and thrombosis. Annu Rev Physiol 2011; 73: 503-514
    • (2011) Annu Rev Physiol , vol.73 , pp. 503-514
    • Esmon, C.T.1    Esmon, N.L.2
  • 56
    • 33847329718 scopus 로고    scopus 로고
    • Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells
    • Bae JS, Yang L, Rezaie AR. Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells. Proc Natl Acad Sci USA 2007; 104: 2867-2872
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 2867-2872
    • Bae, J.S.1    Yang, L.2    Rezaie, A.R.3
  • 57
    • 44449173082 scopus 로고    scopus 로고
    • Pig thrombomodulin binds human thrombin but is a poor cofactor for activation of human protein C and TAFI
    • Roussel JC, Moran CJ, Salvaris EJ et al. Pig thrombomodulin binds human thrombin but is a poor cofactor for activation of human protein C and TAFI. Am J Transplant 2008; 8: 1101-1112
    • (2008) Am J Transplant , vol.8 , pp. 1101-1112
    • Roussel, J.C.1    Moran, C.J.2    Salvaris, E.J.3
  • 58
    • 0030802799 scopus 로고    scopus 로고
    • Xenogeneic endothelial cells activate human prothrombin
    • Siegel JB, Grey ST, Lesnikoski BA et al. Xenogeneic endothelial cells activate human prothrombin. Transplantation 1997; 64: 888-896
    • (1997) Transplantation , vol.64 , pp. 888-896
    • Siegel, J.B.1    Grey, S.T.2    Lesnikoski, B.A.3
  • 59
    • 0030910713 scopus 로고    scopus 로고
    • The evaluation of thrombomodulin activity in porcine to human xenotransplantation
    • Lawson JH, Daniels LJ, Platt JL. The evaluation of thrombomodulin activity in porcine to human xenotransplantation. Transplant Proc 1997; 29: 884-885
    • (1997) Transplant Proc , vol.29 , pp. 884-885
    • Lawson, J.H.1    Daniels, L.J.2    Platt, J.L.3
  • 60
    • 0029997623 scopus 로고    scopus 로고
    • Porcine von Willebrand factor binding to human platelet GPIb induces transmembrane calcium influx
    • Mazzucato M, De Marco L, Pradella P et al. Porcine von Willebrand factor binding to human platelet GPIb induces transmembrane calcium influx. Thromb Haemost 1996; 75: 655-660
    • (1996) Thromb Haemost , vol.75 , pp. 655-660
    • Mazzucato, M.1    De Marco, L.2    Pradella, P.3
  • 61
    • 1842373352 scopus 로고    scopus 로고
    • Activation of human platelets by the membrane-expressed A1 domain of von Willebrand factor
    • Schulte am Esch J 2nd, Cruz MA, Siegel JB et al. Activation of human platelets by the membrane-expressed A1 domain of von Willebrand factor. Blood 1997; 90: 4425-4437
    • (1997) Blood , vol.90 , pp. 4425-4437
    • Schulteam Esch II, J.1    Cruz, M.A.2    Siegel, J.B.3
  • 62
    • 12144279878 scopus 로고    scopus 로고
    • O-linked glycosylation and functional incompatibility of porcine von Willebrand factor for human platelet GPIb receptors
    • Schulte Am Esch J 2nd, Robson SC, Knoefel WT et al. O-linked glycosylation and functional incompatibility of porcine von Willebrand factor for human platelet GPIb receptors. Xenotransplantation 2005; 12: 30-37
    • (2005) Xenotransplantation , vol.12 , pp. 30-37
    • Schulte Am Esch II, J.1    Robson, S.C.2    Knoefel, W.T.3
  • 63
    • 84857585314 scopus 로고    scopus 로고
    • T-cell-mediated immunological barriers to xenotransplantation
    • Scalea J, Hanecamp I, Robson SC et al. T-cell-mediated immunological barriers to xenotransplantation. Xenotransplantation 2012; 19: 23-30
    • (2012) Xenotransplantation , vol.19 , pp. 23-30
    • Scalea, J.1    Hanecamp, I.2    Robson, S.C.3
  • 64
    • 0028960835 scopus 로고
    • Direct and indirect recognition of pig class II antigens by human T cells
    • Yamada K, Sachs DH, DerSimonian H. Direct and indirect recognition of pig class II antigens by human T cells. Transplant Proc 1995; 27: 258-259
    • (1995) Transplant Proc , vol.27 , pp. 258-259
    • Yamada, K.1    Sachs, D.H.2    DerSimonian, H.3
  • 65
    • 84655162276 scopus 로고    scopus 로고
    • Induced anti-non gal antibodies in human xenograft recipients
    • Galili U. Induced anti-non gal antibodies in human xenograft recipients. Transplantation 2012; 93: 11-16
    • (2012) Transplantation , vol.93 , pp. 11-16
    • Galili, U.1
  • 67
    • 0037997349 scopus 로고    scopus 로고
    • Are anti-endothelial cell antibodies a pre-requisite for the acute vascular rejection of xenografts
    • Dorling A. Are anti-endothelial cell antibodies a pre-requisite for the acute vascular rejection of xenografts? Xenotransplantation 2003; 10: 16-23
    • (2003) Xenotransplantation , vol.10 , pp. 16-23
    • Dorling, A.1
  • 69
    • 77954485094 scopus 로고    scopus 로고
    • Histopathology of xenografts in pig to nonhuman primate discordant xenotransplantation
    • Shimizu A, Yamada K. Histopathology of xenografts in pig to nonhuman primate discordant xenotransplantation. Clin Transplant 2010; 24(Suppl 22): 11-15
    • (2010) Clin Transplant , vol.24 , Issue.SUPPL. 22 , pp. 11-15
    • Shimizu, A.1    Yamada, K.2
  • 70
    • 33646383105 scopus 로고    scopus 로고
    • Elicited antibodies in baboons exposed to tissues from alpha1,3-galactosyltransferase gene-knockout pigs
    • Tseng YL, Moran K, Dor FJ et al. Elicited antibodies in baboons exposed to tissues from alpha1,3-galactosyltransferase gene-knockout pigs. Transplantation 2006; 81: 1058-1062
    • (2006) Transplantation , vol.81 , pp. 1058-1062
    • Tseng, Y.L.1    Moran, K.2    Dor, F.J.3
  • 71
    • 7044235964 scopus 로고    scopus 로고
    • Anti-non-Gal porcine endothelial cell antibodies in acute humoral xenograft rejection of hDAF-Transgenic porcine hearts in cynomolgus monkeys
    • Lam TT, Paniagua R, Shivaram G et al. Anti-non-Gal porcine endothelial cell antibodies in acute humoral xenograft rejection of hDAF-Transgenic porcine hearts in cynomolgus monkeys. Xenotransplantation 2004; 11: 531-535
    • (2004) Xenotransplantation , vol.11 , pp. 531-535
    • Lam, T.T.1    Paniagua, R.2    Shivaram, G.3
  • 72
    • 80051897123 scopus 로고    scopus 로고
    • Gal/non-gal antigens in pig tissues and human non-gal antibodies in the galt-ko era
    • Breimer ME. Gal/non-Gal antigens in pig tissues and human non-Gal antibodies in the GalT-KO era. Xenotransplantation 2011; 18: 215-228
    • (2011) Xenotransplantation , vol.18 , pp. 215-228
    • Breimer, M.E.1
  • 74
    • 77953514286 scopus 로고    scopus 로고
    • Investigation of potential carbohydrate antigen targets for human and baboon antibodies
    • Yeh P, Ezzelarab M, Bovin N et al. Investigation of potential carbohydrate antigen targets for human and baboon antibodies. Xenotransplantation 2010; 17: 197-206
    • (2010) Xenotransplantation , vol.17 , pp. 197-206
    • Yeh, P.1    Ezzelarab, M.2    Bovin, N.3
  • 75
    • 50949088377 scopus 로고    scopus 로고
    • Proteomic identification of non-Gal antibody targets after pig-To-primate cardiac xenotransplantation
    • Byrne GW, Stalboerger PG, Davila E et al. Proteomic identification of non-Gal antibody targets after pig-To-primate cardiac xenotransplantation. Xenotransplantation 2008; 15: 268-276
    • (2008) Xenotransplantation , vol.15 , pp. 268-276
    • Byrne, G.W.1    Stalboerger, P.G.2    Davila, E.3
  • 76
    • 84859854200 scopus 로고    scopus 로고
    • Identification of human preformed antibody targets in GTKO pigs
    • Burlak C, Wang ZY, Chihara RK et al. Identification of human preformed antibody targets in GTKO pigs. Xenotransplantation 2012; 19: 92-101
    • (2012) Xenotransplantation , vol.19 , pp. 92-101
    • Burlak, C.1    Wang, Z.Y.2    Chihara, R.K.3
  • 77
    • 79951516280 scopus 로고    scopus 로고
    • Identification of new carbohydrate and membrane protein antigens in cardiac xenotransplantation
    • Byrne GW, Stalboerger PG, Du Z et al. Identification of new carbohydrate and membrane protein antigens in cardiac xenotransplantation. Transplantation 2011; 91: 287-292
    • (2011) Transplantation , vol.91 , pp. 287-292
    • Byrne, G.W.1    Stalboerger, P.G.2    Du, Z.3
  • 78
    • 0028080349 scopus 로고
    • Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection
    • Fodor WL, Williams BL, Matis LA et al. Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection. Proc Natl Acad Sci USA 1994; 91: 11153-11157
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11153-11157
    • Fodor, W.L.1    Williams, B.L.2    Matis, L.A.3
  • 79
    • 0028335298 scopus 로고
    • Expression of human decay accelerating factor in transgenic pigs
    • Cozzi E, Langford GA, Richards A et al. Expression of human decay accelerating factor in transgenic pigs. Transplant Proc 1994; 26: 1402-1403
    • (1994) Transplant Proc , vol.26 , pp. 1402-1403
    • Cozzi, E.1    Langford, G.A.2    Richards, A.3
  • 80
    • 0029033071 scopus 로고
    • Human complement regulatory proteins protect swine-To-primate cardiac xenografts from humoral injury
    • McCurry KR, Kooyman DL, Alvarado CG et al. Human complement regulatory proteins protect swine-To-primate cardiac xenografts from humoral injury. Nat Med 1995; 1: 423-427
    • (1995) Nat Med , vol.1 , pp. 423-427
    • McCurry, K.R.1    Kooyman, D.L.2    Alvarado, C.G.3
  • 82
    • 79961079857 scopus 로고    scopus 로고
    • Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases
    • Hauschild J, Petersen B, Santiago Y et al. Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases. Proc Natl Acad Sci USA. 2011; 108: 12013-12017
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 12013-12017
    • Hauschild, J.1    Petersen, B.2    Santiago, Y.3
  • 83
    • 84867911474 scopus 로고    scopus 로고
    • Efficient talen-mediated gene knockout in livestock
    • Carlson DF, Tan W, Lillico SG et al. Efficient TALEN-mediated gene knockout in livestock. Proc Natl Acad Sci USA 2012; 109: 17382-17387
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 17382-17387
    • Carlson, D.F.1    Tan, W.2    Lillico, S.G.3
  • 84
    • 79955038546 scopus 로고    scopus 로고
    • Versatile co-expression of graft-protective proteins using 2A-linked cassettes
    • Fisicaro N, Londrigan SL, Brady JL et al. Versatile co-expression of graft-protective proteins using 2A-linked cassettes. Xenotransplantation 2011; 18: 121-130
    • (2011) Xenotransplantation , vol.18 , pp. 121-130
    • Fisicaro, N.1    Londrigan, S.L.2    Brady, J.L.3
  • 85
    • 0029959441 scopus 로고    scopus 로고
    • Reduction in the level of Gal(alpha1, 3)Gal in transgenic mice and pigs by the expression of an alpha(1,2)fucosyltransferase
    • Sharma A, Okabe J, Birch P et al. Reduction in the level of Gal(alpha1,3)Gal in transgenic mice and pigs by the expression of an alpha(1,2)fucosyltransferase. Proc Natl Acad Sci USA 1996; 93: 7190-7195
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7190-7195
    • Sharma, A.1    Okabe, J.2    Birch, P.3
  • 86
    • 0035914389 scopus 로고    scopus 로고
    • Remodeling of the major pig xenoantigen by N- Acetylglucosaminyltransferase III in transgenic pig
    • Miyagawa S, Murakami H, Takahagi Y et al. Remodeling of the major pig xenoantigen by N-Acetylglucosaminyltransferase III in transgenic pig. J Biol Chem 2001; 276: 39310-39319
    • (2001) J Biol Chem , vol.276 , pp. 39310-39319
    • Miyagawa, S.1    Murakami, H.2    Takahagi, Y.3
  • 87
    • 0036009120 scopus 로고    scopus 로고
    • Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs
    • Dai Y, Vaught TD, Boone J et al. Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs. Nat Biotechnol 2002; 20: 251-255
    • (2002) Nat Biotechnol , vol.20 , pp. 251-255
    • Dai, Y.1    Vaught, T.D.2    Boone, J.3
  • 88
    • 0037039771 scopus 로고    scopus 로고
    • Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning
    • Lai L, Kolber-Simonds D, Park KW et al. Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 2002; 295: 1089-1092
    • (2002) Science , vol.295 , pp. 1089-1092
    • Lai, L.1    Kolber-Simonds, D.2    Park, K.W.3
  • 89
    • 0347367029 scopus 로고    scopus 로고
    • Production of alpha 1,3-galactosyltransferase-deficient pigs
    • Phelps CJ, Koike C, Vaught TD et al. Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 2003; 299: 411-414
    • (2003) Science , vol.299 , pp. 411-414
    • Phelps, C.J.1    Koike, C.2    Vaught, T.D.3
  • 90
    • 2442567900 scopus 로고    scopus 로고
    • Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations
    • Kolber-Simonds D, Lai L, Watt SR et al. Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations. Proc Natl Acad Sci USA 2004; 101: 7335-7340
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 7335-7340
    • Kolber-Simonds, D.1    Lai, L.2    Watt, S.R.3
  • 91
    • 34547454753 scopus 로고    scopus 로고
    • Production of homozygous alpha-1,3-galactosyltransferase knockout pigs by breeding and somatic cell nuclear transfer
    • Nottle MB, Beebe LF, Harrison SJ et al. Production of homozygous alpha-1,3-galactosyltransferase knockout pigs by breeding and somatic cell nuclear transfer. Xenotransplantation 2007; 14: 339-344
    • (2007) Xenotransplantation , vol.14 , pp. 339-344
    • Nottle, M.B.1    Beebe, L.F.2    Harrison, S.J.3
  • 92
    • 47749149926 scopus 로고    scopus 로고
    • Production of alpha 1,3-galactosyltransferase gene-deficient pigs by somatic cell nuclear transfer: A novel selection method for gal alpha 1,3-Gal antigen-deficient cells
    • Fujimura T, Takahagi Y, Shigehisa T et al. Production of alpha 1,3-galactosyltransferase gene-deficient pigs by somatic cell nuclear transfer: A novel selection method for gal alpha 1,3-Gal antigen-deficient cells. Mol Reprod Dev 2008; 75: 1372-1378
    • (2008) Mol Reprod Dev , vol.75 , pp. 1372-1378
    • Fujimura, T.1    Takahagi, Y.2    Shigehisa, T.3
  • 93
    • 84859268766 scopus 로고    scopus 로고
    • Human CD55 expression blocks hyperacute rejection and restricts complement activation in Gal knockout cardiac xenografts
    • McGregor CG, Ricci D, Miyagi N et al. Human CD55 expression blocks hyperacute rejection and restricts complement activation in Gal knockout cardiac xenografts. Transplantation 2012; 93: 686-692
    • (2012) Transplantation , vol.93 , pp. 686-692
    • McGregor, C.G.1    Ricci, D.2    Miyagi, N.3
  • 94
    • 84873465592 scopus 로고    scopus 로고
    • Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose alpha-1,3-Galactose reduce the humoral barrier to xenotransplantation
    • Lutz AJ, Li P, Estrada JL et al. Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose alpha-1,3-Galactose reduce the humoral barrier to xenotransplantation. Xenotransplantation 2013; 20: 27-35
    • (2013) Xenotransplantation , vol.20 , pp. 27-35
    • Lutz, A.J.1    Li, P.2    Estrada, J.L.3
  • 95
    • 62849111658 scopus 로고    scopus 로고
    • Complement activation and coagulation in xenotransplantation
    • Cowan PJ, d'Apice AJ. Complement activation and coagulation in xenotransplantation. Immunol Cell Biol 2009; 87: 203-208
    • (2009) Immunol Cell Biol , vol.87 , pp. 203-208
    • Cowan, P.J.1    D'Apice, A.J.2
  • 96
    • 20944444434 scopus 로고    scopus 로고
    • Homologous restriction'' in complement lysis: Roles of membrane complement regulators
    • Morgan BP, Berg CW, Harris CL. Homologous restriction'' in complement lysis: Roles of membrane complement regulators. Xenotransplantation 2005; 12: 258-265
    • (2005) Xenotransplantation , vol.12 , pp. 258-265
    • Morgan, B.P.1    Berg, C.W.2    Harris, C.L.3
  • 97
    • 0034721478 scopus 로고    scopus 로고
    • The pig analogue of CD59 protects transgenic mouse hearts from injury by human complement
    • Fisicaro N, Aminian A, Hinchliffe SJ et al. The pig analogue of CD59 protects transgenic mouse hearts from injury by human complement. Transplantation 2000; 70: 963-968
    • (2000) Transplantation , vol.70 , pp. 963-968
    • Fisicaro, N.1    Aminian, A.2    Hinchliffe, S.J.3
  • 98
    • 0036664209 scopus 로고    scopus 로고
    • Protective effects of recombinant human antithrombin III in pig-To-primate renal xenotransplantation
    • Cowan PJ, Aminian A, Barlow H et al. Protective effects of recombinant human antithrombin III in pig-To-primate renal xenotransplantation. Am J Transplant 2002; 2: 520-525
    • (2002) Am J Transplant , vol.2 , pp. 520-525
    • Cowan, P.J.1    Aminian, A.2    Barlow, H.3
  • 99
    • 10744224843 scopus 로고    scopus 로고
    • Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons
    • Loveland BE, Milland J, Kyriakou P et al. Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons. Xenotransplantation 2004; 11: 171-183
    • (2004) Xenotransplantation , vol.11 , pp. 171-183
    • Loveland, B.E.1    Milland, J.2    Kyriakou, P.3
  • 100
    • 2442720110 scopus 로고    scopus 로고
    • Characterization of human CD55 and CD59 transgenic pigs and kidney xenotransplantation in the pig-Tobaboon combination
    • Menoret S, Plat M, Blancho G et al. Characterization of human CD55 and CD59 transgenic pigs and kidney xenotransplantation in the pig-Tobaboon combination. Transplantation 2004; 77: 1468-1471
    • (2004) Transplantation , vol.77 , pp. 1468-1471
    • Menoret, S.1    Plat, M.2    Blancho, G.3
  • 101
    • 0025349483 scopus 로고
    • Release of heparan sulfate from endothelial cells. Implications for pathogenesis of hyperacute rejection
    • Platt JL, Vercellotti GM, Lindman BJ et al. Release of heparan sulfate from endothelial cells. Implications for pathogenesis of hyperacute rejection. J Exp Med 1990; 171: 1363-1368
    • (1990) J Exp Med , vol.171 , pp. 1363-1368
    • Platt, J.L.1    Vercellotti, G.M.2    Lindman, B.J.3
  • 102
    • 67651036210 scopus 로고    scopus 로고
    • Regulation of endothelial protein c receptor shedding by cytokines is mediated through differential activation of map kinase signaling pathways
    • Menschikowski M, Hagelgans A, Eisenhofer G et al. Regulation of endothelial protein C receptor shedding by cytokines is mediated through differential activation of MAP kinase signaling pathways. Exp Cell Res 2009; 315: 2673-2682
    • (2009) Exp Cell Res , vol.315 , pp. 2673-2682
    • Menschikowski, M.1    Hagelgans, A.2    Eisenhofer, G.3
  • 103
    • 0031016802 scopus 로고    scopus 로고
    • Loss of atp diphosphohydrolase activity with endothelial cell activation
    • Robson SC, Kaczmarek E, Siegel JB et al. Loss of ATP diphosphohydrolase activity with endothelial cell activation. J Exp Med 1997; 185: 153-163
    • (1997) J Exp Med , vol.185 , pp. 153-163
    • Robson, S.C.1    Kaczmarek, E.2    Siegel, J.B.3
  • 104
    • 10044240662 scopus 로고    scopus 로고
    • Complete inhibition of acute humoral rejection using regulated expression of membrane-Tethered anticoagulants on xenograft endothelium
    • Chen D, Weber M, McVey JH et al. Complete inhibition of acute humoral rejection using regulated expression of membrane-Tethered anticoagulants on xenograft endothelium. Am J Transplant 2004; 4: 1958-1963
    • (2004) Am J Transplant , vol.4 , pp. 1958-1963
    • Chen, D.1    Weber, M.2    McVey, J.H.3
  • 105
    • 75149169244 scopus 로고    scopus 로고
    • Anti-inflammatory and anticoagulant effects of transgenic expression of human thrombomodulin in mice
    • Crikis S, Zhang XM, Dezfouli S et al. Anti-inflammatory and anticoagulant effects of transgenic expression of human thrombomodulin in mice. Am J Transplant 2010; 10: 242-250
    • (2010) Am J Transplant , vol.10 , pp. 242-250
    • Crikis, S.1    Zhang, X.M.2    Dezfouli, S.3
  • 106
    • 73449090837 scopus 로고    scopus 로고
    • Pigs transgenic for human thrombomodulin have elevated production of activated protein C
    • Petersen B, Ramackers W, Tiede A et al. Pigs transgenic for human thrombomodulin have elevated production of activated protein C. Xenotransplantation 2009; 16: 486-495
    • (2009) Xenotransplantation , vol.16 , pp. 486-495
    • Petersen, B.1    Ramackers, W.2    Tiede, A.3
  • 107
    • 84859852103 scopus 로고    scopus 로고
    • Production of cloned pigs expressing human thrombomodulin in endothelial cells
    • Yazaki S, Iwamoto M, Onishi A et al. Production of cloned pigs expressing human thrombomodulin in endothelial cells. Xenotransplantation 2012; 19: 82-91
    • (2012) Xenotransplantation , vol.19 , pp. 82-91
    • Yazaki, S.1    Iwamoto, M.2    Onishi, A.3
  • 108
    • 79952594087 scopus 로고    scopus 로고
    • Characterization of transgenic pigs that express human decay accelerating factor and cell membrane-Tethered human tissue factor pathway inhibitor
    • Lee HJ, Lee BC, Kim YH et al. Characterization of transgenic pigs that express human decay accelerating factor and cell membrane-Tethered human tissue factor pathway inhibitor. Reprod Domest Anim 2011; 46: 325-332
    • (2011) Reprod Domest Anim , vol.46 , pp. 325-332
    • Lee, H.J.1    Lee, B.C.2    Kim, Y.H.3
  • 109
    • 77956469984 scopus 로고    scopus 로고
    • Atorvastatin or transgenic expression of TFPI inhibits coagulation initiated by anti-nonGal IgG binding to porcine aortic endothelial cells
    • Lin CC, Ezzelarab M, Hara H et al. Atorvastatin or transgenic expression of TFPI inhibits coagulation initiated by anti-nonGal IgG binding to porcine aortic endothelial cells. J Thromb Haemost 2010; 8: 2001-2010
    • (2010) J Thromb Haemost , vol.8 , pp. 2001-2010
    • Lin, C.C.1    Ezzelarab, M.2    Hara, H.3
  • 110
    • 12644288616 scopus 로고    scopus 로고
    • Identification and characterization of CD39/vascular ATP diphosphohydrolase
    • Kaczmarek E, Koziak K, Sevigny J et al. Identification and characterization of CD39/vascular ATP diphosphohydrolase. J Biol Chem 1996; 271: 33116-33122
    • (1996) J Biol Chem , vol.271 , pp. 33116-33122
    • Kaczmarek, E.1    Koziak, K.2    Sevigny, J.3
  • 111
    • 85047692190 scopus 로고    scopus 로고
    • Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation
    • Dwyer KM, Robson SC, Nandurkar HH et al. Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation. J Clin Invest 2004; 113: 1440-1446
    • (2004) J Clin Invest , vol.113 , pp. 1440-1446
    • Dwyer, K.M.1    Robson, S.C.2    Nandurkar, H.H.3
  • 112
    • 78649867585 scopus 로고    scopus 로고
    • Transgenic overexpression of CD39 protects against renal ischemia-reperfusion and transplant vascular injury
    • Crikis S, Lu B, Murray-Segal LM et al. Transgenic overexpression of CD39 protects against renal ischemia-reperfusion and transplant vascular injury. Am J Transplant 2010; 10: 2586-2595
    • (2010) Am J Transplant , vol.10 , pp. 2586-2595
    • Crikis, S.1    Lu, B.2    Murray-Segal, L.M.3
  • 113
    • 84862697341 scopus 로고    scopus 로고
    • Ectonucleotide triphosphate diphosphohydrolase-1 (CD39) mediates resistance to occlusive arterial thrombus formation after vascular injury in mice
    • Huttinger ZM, Milks MW, Nickoli MS et al. Ectonucleotide triphosphate diphosphohydrolase-1 (CD39) mediates resistance to occlusive arterial thrombus formation after vascular injury in mice. Am J Pathol 2012; 181: 322-333
    • (2012) Am J Pathol , vol.181 , pp. 322-333
    • Huttinger, Z.M.1    Milks, M.W.2    Nickoli, M.S.3
  • 114
    • 80055116987 scopus 로고    scopus 로고
    • Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury
    • Cai M, Huttinger ZM, He H et al. Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury. J Mol Cell Cardiol 2011; 51: 927-935
    • (2011) J Mol Cell Cardiol , vol.51 , pp. 927-935
    • Cai, M.1    Huttinger, Z.M.2    He, H.3
  • 115
    • 84859640267 scopus 로고    scopus 로고
    • Transgenic swine: Expression of human CD39 protects against myocardial injury
    • Wheeler DG, Joseph ME, Mahamud SD et al. Transgenic swine: Expression of human CD39 protects against myocardial injury. J Mol Cell Cardiol 2012; 52: 958-961
    • (2012) J Mol Cell Cardiol , vol.52 , pp. 958-961
    • Wheeler, D.G.1    Joseph, M.E.2    Mahamud, S.D.3
  • 116
    • 81455132540 scopus 로고    scopus 로고
    • Xenotransplantation of galactosyl-Transferase knockout, cd55, cd59, cd39, and fucosyltransferase transgenic pig kidneys into baboons
    • Le Bas-Bernardet S, Tillou X, Poirier N et al. Xenotransplantation of galactosyl-Transferase knockout, CD55, CD59, CD39, and fucosyltransferase transgenic pig kidneys into baboons. Transplant Proc 2011; 43: 3426-3430
    • (2011) Transplant Proc , vol.43 , pp. 3426-3430
    • Le Bas-Bernardet, S.1    Tillou, X.2    Poirier, N.3
  • 117
    • 77957570734 scopus 로고    scopus 로고
    • Role of heme oxygenase-1 in transplantation
    • Ollinger R, Pratschke J. Role of heme oxygenase-1 in transplantation. Transpl Int 2010; 23: 1071-1081
    • (2010) Transpl Int , vol.23 , pp. 1071-1081
    • Ollinger, R.1    Pratschke, J.2
  • 118
    • 84867153791 scopus 로고    scopus 로고
    • Generation and characterization of human heme oxygenase-1 transgenic pigs
    • Yeom HJ, Koo OJ, Yang J et al. Generation and characterization of human heme oxygenase-1 transgenic pigs. PLoS One 2012; 7: E46646
    • (2012) PLoS One , vol.7
    • Yeom, H.J.1    Koo, O.J.2    Yang, J.3
  • 119
    • 83755225193 scopus 로고    scopus 로고
    • Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys
    • Petersen B, Ramackers W, Lucas-Hahn A et al. Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys. Xenotransplantation 2011; 18: 355-368
    • (2011) Xenotransplantation , vol.18 , pp. 355-368
    • Petersen, B.1    Ramackers, W.2    Lucas-Hahn, A.3
  • 120
    • 73449142842 scopus 로고    scopus 로고
    • Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli
    • Oropeza M, Petersen B, Carnwath JW et al. Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli. Xenotransplantation 2009; 16: 522-534
    • (2009) Xenotransplantation , vol.16 , pp. 522-534
    • Oropeza, M.1    Petersen, B.2    Carnwath, J.W.3
  • 121
    • 79960310741 scopus 로고    scopus 로고
    • Generation of soluble human tumor necrosis factor-Alpha receptor 1-Fc transgenic pig
    • Cho B, Koo OJ, Hwang JI et al. Generation of soluble human tumor necrosis factor-Alpha receptor 1-Fc transgenic pig. Transplantation 2011; 92: 139-147
    • (2011) Transplantation , vol.92 , pp. 139-147
    • Cho, B.1    Koo, O.J.2    Hwang, J.I.3
  • 122
    • 58949084485 scopus 로고    scopus 로고
    • HLA-E/human beta2-microglobulin transgenic pigs: Protection against xenogeneic human anti-pig natural killer cell cytotoxicity
    • Weiss EH, Lilienfeld BG, Muller S et al. HLA-E/human beta2-microglobulin transgenic pigs: Protection against xenogeneic human anti-pig natural killer cell cytotoxicity. Transplantation 2009; 87: 35-43
    • (2009) Transplantation , vol.87 , pp. 35-43
    • Weiss, E.H.1    Lilienfeld, B.G.2    Muller, S.3
  • 123
    • 84863011902 scopus 로고    scopus 로고
    • Human CD47 expression permits survival of porcine cells in immunodeficient mice that express SIRPalpha capable of binding to human CD47
    • Wang C, Wang H, Ide K et al. Human CD47 expression permits survival of porcine cells in immunodeficient mice that express SIRPalpha capable of binding to human CD47. Cell Transplant 2011; 20: 1915-1920
    • (2011) Cell Transplant , vol.20 , pp. 1915-1920
    • Wang, C.1    Wang, H.2    Ide, K.3
  • 124
    • 84857569876 scopus 로고    scopus 로고
    • Human tnf-related apoptosis-inducing ligand-expressing dendritic cells from transgenic pigs attenuate human xenogeneic t cell responses
    • Kemter E, Lieke T, Kessler B et al. Human TNF-related apoptosis-inducing ligand-expressing dendritic cells from transgenic pigs attenuate human xenogeneic T cell responses. Xenotransplantation 2012; 19: 40-51
    • (2012) Xenotransplantation , vol.19 , pp. 40-51
    • Kemter, E.1    Lieke, T.2    Kessler, B.3
  • 125
    • 79952107552 scopus 로고    scopus 로고
    • The immense potential of xenotransplantation in surgery
    • Cooper DK, Ayares D. The immense potential of xenotransplantation in surgery. Int J Surg 2011; 9: 122-129
    • (2011) Int J Surg , vol.9 , pp. 122-129
    • Cooper, D.K.1    Ayares, D.2
  • 126
    • 23744460627 scopus 로고    scopus 로고
    • Transgenic expression of ctla4-ig by fetal pig neurons for xenotransplantation
    • Martin C, Plat M, Nerriere-Daguin V et al. Transgenic expression of CTLA4-Ig by fetal pig neurons for xenotransplantation. Transgenic Res 2005; 14: 373-384
    • (2005) Transgenic Res , vol.14 , pp. 373-384
    • Martin, C.1    Plat, M.2    Nerriere-Daguin, V.3
  • 127
    • 84861898204 scopus 로고    scopus 로고
    • Xenografted islet cell clusters from inslea29y transgenic pigs rescue diabetes and prevent immune rejection in humanized mice
    • Klymiuk N, van Buerck L, Bahr A et al. Xenografted islet cell clusters from INSLEA29Y transgenic pigs rescue diabetes and prevent immune rejection in humanized mice. Diabetes 2012; 61: 1527-1532
    • (2012) Diabetes , vol.61 , pp. 1527-1532
    • Klymiuk, N.1    Van Buerck, L.2    Bahr, A.3
  • 128
    • 70349719520 scopus 로고    scopus 로고
    • Production and characterization of transgenic pigs expressing porcine ctla4-ig
    • Phelps CJ, Ball SF, Vaught TD et al. Production and characterization of transgenic pigs expressing porcine CTLA4-Ig. Xenotransplantation 2009; 16: 477-485
    • (2009) Xenotransplantation , vol.16 , pp. 477-485
    • Phelps, C.J.1    Ball, S.F.2    Vaught, T.D.3
  • 129
    • 80052685083 scopus 로고    scopus 로고
    • First experience with the use of a recombinant CD3 immunotoxin as induction therapy in pig-To-primate xenotransplantation: The effect of T-cell depletion on outcome
    • Nishimura H, Scalea J, Wang Z et al. First experience with the use of a recombinant CD3 immunotoxin as induction therapy in pig-To-primate xenotransplantation: The effect of T-cell depletion on outcome. Transplantation 2011; 92: 641-647
    • (2011) Transplantation , vol.92 , pp. 641-647
    • Nishimura, H.1    Scalea, J.2    Wang, Z.3
  • 130
    • 24644482765 scopus 로고    scopus 로고
    • Cardiac xenotransplantation: Recent preclinical progress with 3-month median survival
    • McGregor CG, Davies WR, Oi K et al. Cardiac xenotransplantation: Recent preclinical progress with 3-month median survival. J Thorac Cardiovasc Surg 2005; 130: 844-851
    • (2005) J Thorac Cardiovasc Surg , vol.130 , pp. 844-851
    • McGregor, C.G.1    Davies, W.R.2    Oi, K.3
  • 131
    • 84857651619 scopus 로고    scopus 로고
    • B-cell depletion extends the survival of gtko.hcd46tg pig heart xenografts in baboons for up to 8 months
    • Mohiuddin MM, Corcoran PC, Singh AK et al. B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months. Am J Transplant 2012; 12: 763-771
    • (2012) Am J Transplant , vol.12 , pp. 763-771
    • Mohiuddin, M.M.1    Corcoran, P.C.2    Singh, A.K.3
  • 132
    • 77949846514 scopus 로고    scopus 로고
    • Investigation of lymphocyte depletion and repopulation using alemtuzumab (campath-1h) in cynomolgus monkeys
    • Van Der Windt DJ, Smetanka C, Macedo C et al. Investigation of lymphocyte depletion and repopulation using alemtuzumab (Campath-1H) in cynomolgus monkeys. Am J Transplant 2010; 10: 773-783
    • (2010) Am J Transplant , vol.10 , pp. 773-783
    • Van Der Windt, D.J.1    Smetanka, C.2    Macedo, C.3
  • 133
    • 13444282227 scopus 로고    scopus 로고
    • Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience
    • Kuwaki K, Tseng YL, Dor FJ et al. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience. Nat Med 2005; 11: 29-31
    • (2005) Nat Med , vol.11 , pp. 29-31
    • Kuwaki, K.1    Tseng, Y.L.2    Dor, F.J.3
  • 134
    • 0033965079 scopus 로고    scopus 로고
    • Thromboembolic complications after treatment with monoclonal antibody against cd40 ligand
    • Kawai T, Andrews D, Colvin RB et al. Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand. Nat Med 2000; 6: 114
    • (2000) Nat Med , vol.6 , pp. 114
    • Kawai, T.1    Andrews, D.2    Colvin, R.B.3
  • 135
    • 0036677935 scopus 로고    scopus 로고
    • Anti-cd154 monoclonal antibody and thromboembolism revisted
    • Knosalla C, Gollackner B, Cooper DK. Anti-CD154 monoclonal antibody and thromboembolism revisted. Transplantation 2002; 74: 416-417
    • (2002) Transplantation , vol.74 , pp. 416-417
    • Knosalla, C.1    Gollackner, B.2    Cooper, D.K.3
  • 136
    • 84865391026 scopus 로고    scopus 로고
    • Costimulation blockade in pig artery patch xenotransplantation-A simple model to monitor the adaptive immune response in nonhuman primates
    • Ezzelarab MB, Ekser B, Echeverri G et al. Costimulation blockade in pig artery patch xenotransplantation-A simple model to monitor the adaptive immune response in nonhuman primates. Xenotransplantation 2012; 19: 221-232
    • (2012) Xenotransplantation , vol.19 , pp. 221-232
    • Ezzelarab, M.B.1    Ekser, B.2    Echeverri, G.3
  • 137
    • 79955527672 scopus 로고    scopus 로고
    • CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates
    • Thompson P, Cardona K, Russell M et al. CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates. Am J Transplant 2011; 11: 947-957
    • (2011) Am J Transplant , vol.11 , pp. 947-957
    • Thompson, P.1    Cardona, K.2    Russell, M.3
  • 138
    • 84878766139 scopus 로고    scopus 로고
    • Impact of intensive statin use on the level of inflammation and platelet activation in stable angina after percutaneous coronary intervention: A clinical study
    • Li Q, Deng SB, Xia S et al. Impact of intensive statin use on the level of inflammation and platelet activation in stable angina after percutaneous coronary intervention: A clinical study. Med Clin (Barc) 2012; 140: 532-536
    • (2012) Med Clin (Barc , vol.140 , pp. 532-536
    • Li, Q.1    Deng, S.B.2    Xia, S.3
  • 139
    • 53449101072 scopus 로고    scopus 로고
    • Atorvastatin down-regulates the primate cellular response to porcine aortic endothelial cells in vitro
    • Ezzelarab M, Welchons D, Torres C et al. Atorvastatin down-regulates the primate cellular response to porcine aortic endothelial cells in vitro. Transplantation 2008; 86: 733-737
    • (2008) Transplantation , vol.86 , pp. 733-737
    • Ezzelarab, M.1    Welchons, D.2    Torres, C.3
  • 140
    • 10744228498 scopus 로고    scopus 로고
    • Suppression of natural and elicited antibodies in pig-To-baboon heart transplantation using a human antihuman CD154 mAb-based regimen
    • Kuwaki K, Knosalla C, Dor FJ et al. Suppression of natural and elicited antibodies in pig-To-baboon heart transplantation using a human antihuman CD154 mAb-based regimen. Am J Transplant 2004; 4: 363-372
    • (2004) Am J Transplant , vol.4 , pp. 363-372
    • Kuwaki, K.1    Knosalla, C.2    Dor, F.J.3
  • 141
    • 29144436254 scopus 로고    scopus 로고
    • Alpha1,3-Galactosyltransferase geneknockout pig heart transplantation in baboons with survival approaching 6 months
    • Tseng YL, Kuwaki K, Dor FJ et al. alpha1,3-Galactosyltransferase geneknockout pig heart transplantation in baboons with survival approaching 6 months. Transplantation 2005; 80: 1493-1500
    • (2005) Transplantation , vol.80 , pp. 1493-1500
    • Tseng, Y.L.1    Kuwaki, K.2    Dor, F.J.3
  • 142
    • 29144483474 scopus 로고    scopus 로고
    • Effects of long-Term administration of high-dose recombinant human antithrombin in immunosuppressed primate recipients of porcine xenografts
    • Cozzi E, Simioni P, Boldrin M et al. Effects of long-Term administration of high-dose recombinant human antithrombin in immunosuppressed primate recipients of porcine xenografts. Transplantation 2005; 80: 1501-1510
    • (2005) Transplantation , vol.80 , pp. 1501-1510
    • Cozzi, E.1    Simioni, P.2    Boldrin, M.3
  • 143
    • 78751647078 scopus 로고    scopus 로고
    • Effects of long-Term administration of recombinant human protein C in xenografted primates
    • Simioni P, Boldrin M, Gavasso S et al. Effects of long-Term administration of recombinant human protein C in xenografted primates. Transplantation 2011; 91: 161-168
    • (2011) Transplantation , vol.91 , pp. 161-168
    • Simioni, P.1    Boldrin, M.2    Gavasso, S.3
  • 144
    • 79955019129 scopus 로고    scopus 로고
    • Which anti-platelet therapies might be beneficial in xenotransplantation
    • Schmelzle M, Cowan PJ, Robson SC. Which anti-platelet therapies might be beneficial in xenotransplantation? Xenotransplantation 2011; 18: 79-87
    • (2011) Xenotransplantation , vol.18 , pp. 79-87
    • Schmelzle, M.1    Cowan, P.J.2    Robson, S.C.3
  • 145
    • 38549088096 scopus 로고    scopus 로고
    • HLA-mismatched renal transplantation without maintenance immunosuppression
    • Kawai T, Cosimi AB, Spitzer TR et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008; 358: 353-361
    • (2008) N Engl J Med , vol.358 , pp. 353-361
    • Kawai, T.1    Cosimi, A.B.2    Spitzer, T.R.3
  • 146
    • 3042760301 scopus 로고    scopus 로고
    • Bone marrow transplantation from alpha1,3-galactosyltransferase gene-knockout pigs in baboons
    • Tseng YL, Dor FJ, Kuwaki K et al. Bone marrow transplantation from alpha1,3-galactosyltransferase gene-knockout pigs in baboons. Xenotransplantation 2004; 11: 361-370
    • (2004) Xenotransplantation , vol.11 , pp. 361-370
    • Tseng, Y.L.1    Dor, F.J.2    Kuwaki, K.3
  • 147
    • 77955865098 scopus 로고    scopus 로고
    • CD47 in xenograft rejection and tolerance induction
    • Yang YG. CD47 in xenograft rejection and tolerance induction. Xenotransplantation 2010; 17: 267-273
    • (2010) Xenotransplantation , vol.17 , pp. 267-273
    • Yang, Y.G.1
  • 148
    • 56049107067 scopus 로고    scopus 로고
    • In vitro suppression of xenoimmune-mediated macrophage activation by human cd4cd25 regulatory t cells
    • Fu Y, Yi S, Wu J et al. In vitro suppression of xenoimmune-mediated macrophage activation by human CD4CD25 regulatory T cells. Transplantation 2008; 86: 865-874
    • (2008) Transplantation , vol.86 , pp. 865-874
    • Fu, Y.1    Yi, S.2    Wu, J.3
  • 149
    • 34547514184 scopus 로고    scopus 로고
    • Characterization and expansion of baboon cd4cd25 treg cells for potential use in a non-human primate xenotransplantation model
    • Porter CM, Horvath-Arcidiacono JA, Singh AK et al. Characterization and expansion of baboon CD4CD25 Treg cells for potential use in a non-human primate xenotransplantation model. Xenotransplantation 2007; 14: 298-308
    • (2007) Xenotransplantation , vol.14 , pp. 298-308
    • Porter, C.M.1    Horvath-Arcidiacono, J.A.2    Singh, A.K.3
  • 150
    • 49149099071 scopus 로고    scopus 로고
    • In vitro expanded human cd4cd25 regulatory t cells are potent suppressors of t-cell-mediated xenogeneic responses
    • Wu J, Yi S, Ouyang L et al. In vitro expanded human CD4CD25 regulatory T cells are potent suppressors of T-cell-mediated xenogeneic responses. Transplantation 2008; 85: 1841-1848
    • (2008) Transplantation , vol.85 , pp. 1841-1848
    • Wu, J.1    Yi, S.2    Ouyang, L.3
  • 151
    • 77951060167 scopus 로고    scopus 로고
    • Foxp3 regulates human natural cd4cd25 regulatory t-cell-mediated suppression of xenogeneic response
    • Sun L, Yi S, O'Connell PJ. Foxp3 regulates human natural CD4CD25 regulatory T-cell-mediated suppression of xenogeneic response. Xenotransplantation 2010; 17: 121-130
    • (2010) Xenotransplantation , vol.17 , pp. 121-130
    • Sun, L.1    Yi, S.2    O'Connell, P.J.3
  • 152
    • 84886727882 scopus 로고    scopus 로고
    • Improvement of subcutaneous bioartificial pancreas vascularization and function by co-encapsulation of pig islets and mesenchymal stem cells in primates
    • e-pub ahead of print
    • Veriter S, Gianello P, Igarashi Y et al. Improvement of subcutaneous bioartificial pancreas vascularization and function by co-encapsulation of pig islets and mesenchymal stem cells in primates. Cell Transplant 2013; (e-pub ahead of print
    • (2013) Cell Transplant
    • Veriter, S.1    Gianello, P.2    Igarashi, Y.3
  • 155
    • 84866492475 scopus 로고    scopus 로고
    • Do mesenchymal stem cells function across species barriers? Relevance for xenotransplantation
    • Li J, Ezzelarab MB, Cooper DK. Do mesenchymal stem cells function across species barriers? Relevance for xenotransplantation. Xenotransplantation 2012; 19: 273-285
    • (2012) Xenotransplantation , vol.19 , pp. 273-285
    • Li, J.1    Ezzelarab, M.B.2    Cooper, D.K.3
  • 156
    • 79959715815 scopus 로고    scopus 로고
    • Genetically-modified pig mesenchymal stromal cells: Xenoantigenicity and effect on human T-cell xenoresponses
    • Ezzelarab M, Ezzelarab C, Wilhite T et al. Genetically-modified pig mesenchymal stromal cells: Xenoantigenicity and effect on human T-cell xenoresponses. Xenotransplantation 2011; 18: 183-195
    • (2011) Xenotransplantation , vol.18 , pp. 183-195
    • Ezzelarab, M.1    Ezzelarab, C.2    Wilhite, T.3
  • 157
    • 84858686478 scopus 로고    scopus 로고
    • Adipose-derived mesenchymal stromal cells from genetically modified pigs: Immunogenicity and immune modulatory properties
    • Kumar G, Hara H, Long C et al. Adipose-derived mesenchymal stromal cells from genetically modified pigs: Immunogenicity and immune modulatory properties. Cytotherapy 2012; 14: 494-504
    • (2012) Cytotherapy , vol.14 , pp. 494-504
    • Kumar, G.1    Hara, H.2    Long, C.3
  • 158
    • 0033851858 scopus 로고    scopus 로고
    • An approach to the control of disease transmission in pig-To-human xenotransplantation
    • Onions D, Cooper DK, Alexander TJ et al. An approach to the control of disease transmission in pig-To-human xenotransplantation. Xenotransplantation 2000; 7: 143-155
    • (2000) Xenotransplantation , vol.7 , pp. 143-155
    • Onions, D.1    Cooper, D.K.2    Alexander, T.J.3
  • 159
    • 66149128857 scopus 로고    scopus 로고
    • First WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials: Changsha, China, 19-21 November 2008. The Changsha Communique
    • First WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials: Changsha, China, 19-21 November 2008. The Changsha Communique. Xenotransplantation 2009; 16: 61-63
    • (2009) Xenotransplantation , vol.16 , pp. 61-63
  • 160
    • 84859833492 scopus 로고    scopus 로고
    • Xenotransplantation-Associated infectious risk: A WHO consultation
    • Fishman JA, Scobie L, Takeuchi Y. Xenotransplantation-Associated infectious risk: A WHO consultation. Xenotransplantation 2012; 19: 72-81
    • (2012) Xenotransplantation , vol.19 , pp. 72-81
    • Fishman, J.A.1    Scobie, L.2    Takeuchi, Y.3
  • 161
    • 76349095580 scopus 로고    scopus 로고
    • Can human viruses infect porcine xenografts
    • Millard AL, Mueller NJ. Can human viruses infect porcine xenografts? Xenotransplantation 2010; 17: 6-10
    • (2010) Xenotransplantation , vol.17 , pp. 6-10
    • Millard, A.L.1    Mueller, N.J.2
  • 162
    • 33747127485 scopus 로고    scopus 로고
    • Allosensitization does not increase the risk of xenoreactivity to alpha1,3-galactosyltransferase geneknockout miniature swine in patients on transplantation waiting lists
    • Wong BS, Yamada K, Okumi M et al. Allosensitization does not increase the risk of xenoreactivity to alpha1,3-galactosyltransferase geneknockout miniature swine in patients on transplantation waiting lists. Transplantation 2006; 82: 314-319
    • (2006) Transplantation , vol.82 , pp. 314-319
    • Wong, B.S.1    Yamada, K.2    Okumi, M.3
  • 163
    • 0742305872 scopus 로고    scopus 로고
    • Absence of humoral and cellular alloreactivity in baboons sensitized to pig antigens
    • Baertschiger RM, Dor FJ, Prabharasuth D et al. Absence of humoral and cellular alloreactivity in baboons sensitized to pig antigens. Xenotransplantation 2004; 11: 27-32
    • (2004) Xenotransplantation , vol.11 , pp. 27-32
    • Baertschiger, R.M.1    Dor, F.J.2    Prabharasuth, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.