CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates

American Journal of Transplantation

Volumn 11, Issue 5, 2011, Pages 947-957

  Thompson, P ^a   Cardona, K ^a   Russell, M ^a   Badell, I R ^a   Shaffer, V ^a   Korbutt, G ^b   Rayat, G R ^b   Cano, J ^a   Song, M ^a   Jiang, W ^a   Strobert, E ^c   Rajotte, R ^b   Pearson, T ^a   Kirk, A D ^a   Larsen, C P ^a  

^a EMORY UNIVERSITY   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c EMORY UNIVERSITY   (United States)

Author keywords

Costimulation blockade; depletion; islets; monoclonoal antibodies; type 1 diabetes; xenotransplantation

Indexed keywords

BASILIXIMAB; BELATACEPT; C PEPTIDE; CD40 ANTIGEN; CD40 LIGAND MONOCLONAL ANTIBODY; CHI220 ANTIBODY; RAPAMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOMEGALOVIRUS; ENGRAFTMENT; FEMALE; GRAFT RECIPIENT; GRAFT REJECTION; IMMUNE DEFICIENCY; MACACA; MALE; NEWBORN; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; SWINE; T LYMPHOCYTE; TISSUE SURVIVAL; TISSUE TRANSPLANTATION; XENOGRAFT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD40; CD40 LIGAND; FEMALE; GRAFT SURVIVAL; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; ISLETS OF LANGERHANS TRANSPLANTATION; MACACA MULATTA; MALE; PRIMATES; RECEPTORS, INTERLEUKIN-2; RECOMBINANT FUSION PROTEINS; SIROLIMUS; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 79955527672     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2011.03509.x     Document Type: Article

References (43)

1. Shapiro AM, Lakey JR, Ryan EA, et al,. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343: 230-238. (Pubitemid 30490390)
2. Shapiro AM, Ricordi C, Hering BJ, et al,. International trial of the Edmonton protocol for islet transplantation. N Engl J Med 2006; 355: 1318-1330. (Pubitemid 44465460)
3. Hering BJ, Walawalkar N,. Pig-to-nonhuman primate islet xenotransplantation. Transpl Immunol 2009; 21: 81-86.
4. Korbutt GS, Elliott JF, Ao Z, Smith DK, Warnock GL, Rajotte RV,. Large scale isolation, growth, and function of porcine neonatal islet cells. J Clin Invest 1996; 97: 2119-2129. (Pubitemid 26143967)
5. Rayat GR, Rajotte RV, Korbutt GS,. Potential application of neonatal porcine islets as treatment for type 1 diabetes: A review. Ann N Y Acad Sci 1999; 875: 175-188. (Pubitemid 29349070)
6. Yang YG, Sykes M,. Xenotransplantation: Current status and a perspective on the future. Nat Rev Immunol 2007; 7: 519-531. (Pubitemid 46987781)
7. Dufrane D, Gianello P,. Pig islet xenotransplantation into non-human primate model. Transplantation 2008; 86: 753-760.
8. Cardona K, Korbutt GS, Milas Z, et al,. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med 2006; 12: 304-306. (Pubitemid 43355077)
9. Hering BJ, Wijkstrom M, Graham ML, et al,. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 2006; 12: 301-303. (Pubitemid 43355076)
10. Ford ML, Larsen CP,. Translating costimulation blockade to the clinic: Lessons learned from three pathways. Immunol Rev 2009; 229: 294-306.
11. Kirk AD, Knechtle SJ, Sollinger HW,. Preliminary results of the use of humanized anti-CD154 in human renal allotransplantation (abstract). Am J Transplant 2001; 1 (Suppl 1): 1.
12. Boumpas DT, Furie R, Manzi S, et al,. A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. Arthritis Rheum 2003; 48: 719-727. (Pubitemid 36302008)
13. Pearson TC, Trambley J, Odom K, et al,. Anti-CD40 therapy extends renal allograft survival in rhesus macaques. Transplantation 2002; 74: 933-940. (Pubitemid 35191239)
14. Haanstra KG, Ringers J, Sick EA, et al,. Prevention of kidney allograft rejection using anti-CD40 and anti-CD86 in primates. Transplantation 2003; 75: 637-643. (Pubitemid 36337361)
15. Haanstra KG, Sick EA, Ringers J, et al,. Costimulation blockade followed by a 12-week period of cyclosporine a facilitates prolonged drug-free survival of rhesus monkey kidney allografts. Transplantation 2005; 79: 1623-1626. (Pubitemid 40847596)
16. Aoyagi T, Yamashita K, Suzuki T, et al,. A human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys: Induction and maintenance therapy. Am J Transplant 2009; 9: 1732-1741.
17. Larsen CP, Elwood ET, Alexander DZ, et al,. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381: 434-438. (Pubitemid 26162734)
18. Adams AB, Shirasugi N, Jones TR, et al,. Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival. J Immunol 2005; 174: 542-550. (Pubitemid 40007445)
19. Cardona K, Milas Z, Strobert E, et al,. Engraftment of adult porcine islet xenografts in diabetic nonhuman primates through targeting of costimulation pathways. Am J Transplant 2007; 7: 2260-2268. (Pubitemid 47347856)
20. Van Der Windt DJ, Bottino R, Casu A, et al,. Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets. Am J Transplant 2009; 9: 2716-2726.
21. Casu A, Bottino R, Balamurugan AN, et al,. Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: Implications for translation into clinical practice. Diabetologia 2008; 51: 120-129. (Pubitemid 350197988)
22. Adams AB, Shirasugi N, Durham MM, et al,. Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates. Diabetes 2002; 51: 265-270. (Pubitemid 34764779)
23. Institute of Laboratory Animal Resources (U.S.). Committee on care and use of laboratory animals. Guide for the care and use of laboratory animals. NIH publication. Bethesda, MD: U.S. Dept. of Health and Human Services, Public Health Service.
24. Lobashevsky A, Smith JP, Kasten-Jolly J, et al,. Identification of DRB alleles in rhesus monkeys using polymerase chain reaction-sequence-specific primers (PCR-SSP) amplification. Tissue Antigens 1999; 54: 254-263. (Pubitemid 29443845)
25. Switzer WM, Shanmugam V, Chapman L, Heneine W,. Polymerase chain reaction assays for the diagnosis of infection with the porcine endogenous retrovirus and the detection of pig cells in human and nonhuman recipients of pig xenografts. Transplantation 1999; 68: 183-188. (Pubitemid 29360273)
26. Larsen CP, Pearson TC,. The CD40 pathway in allograft rejection, acceptance, and tolerance. Curr Opin Immunol 1997; 9: 641-647. (Pubitemid 27485291)
27. Kirk AD, Harlan DM, Armstrong NN, et al,. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci U S A 1997; 94: 8789-8794. (Pubitemid 27335118)
28. Kenyon NS, Chatzipetrou M, Masetti M, et al,. Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154. Proc Natl Acad Sci U S A 1999; 96: 8132-8137. (Pubitemid 29328420)
29. Davis JC, Jr,., Totoritis MC, Rosenberg J, Sklenar TA, Wofsy D,. Phase I clinical trial of a monoclonal antibody against CD40-ligand (IDEC-131) in patients with systemic lupus erythematosus. J Rheumatol 2001; 28: 95-101. (Pubitemid 32062030)
30. Kalunian KC, Davis JC, Jr,., Merrill JT, Totoritis MC, Wofsy D,. Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: A randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2002; 46: 3251-3258. (Pubitemid 35453534)
31. Vincenti F,. What's in the pipeline? New immunosuppressive drugs in transplantation. Am J Transplant 2002; 2: 898-903. (Pubitemid 36330218)
32. Henn V, Slupsky JR, Grafe M, et al,. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998; 391: 591-594. (Pubitemid 28157601)
33. Andre P, Prasad KS, Denis CV, et al,. CD40L stabilizes arterial thrombi by a beta3 integrin-dependent mechanism. Nat Med 2002; 8: 247-252. (Pubitemid 34250102)
34. Crow AR, Leytin V, Starkey AF, Rand ML, Lazarus AH,. CD154 (CD40 ligand)-deficient mice exhibit prolonged bleeding time and decreased shear-induced platelet aggregates. J Thromb Haemost 2003; 1: 850-852.
35. Buhler L, Deng S, O'Neil J, et al,. Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non-myeloablative regimen and CD154 blockade. Xenotransplantation 2002; 9: 3-13. (Pubitemid 36358219)
36. Kirchhof N, Shibata S, Wijkstrom M, et al,. Reversal of diabetes in non-immunosuppressed rhesus macaques by intraportal porcine islet xenografts precedes acute cellular rejection. Xenotransplantation 2004; 11: 396-407. (Pubitemid 39128209)
37. Rood PP, Bottino R, Balamurugan AN, et al,. Reduction of early graft loss after intraportal porcine islet transplantation in monkeys. Transplantation 2007; 83: 202-210. (Pubitemid 46185211)
38. Weaver TA, Charafeddine AH, Kirk AD,. Costimulation blockade: Towards clinical application. Front Biosci 2008; 13: 2120-2139. (Pubitemid 351589240)
39. Gilson CR, Milas Z, Gangappa S, et al,. Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation. J Immunol 2009; 183: 1625-1635.
40. Kirk AD., 4D11: The second mouse? Am J Transplant 2009; 9: 1701-1702.
41. Kasran A, Boon L, Wortel CH, et al,. Safety and tolerability of antagonist anti-human CD40 Mab ch5D12 in patients with moderate to severe Crohn's disease. Aliment Pharmacol Ther 2005; 22: 111-122. (Pubitemid 41039699)
42. Advani R, Forero-Torres A, Furman RR, et al,. Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma. J Clin Oncol 2009; 27: 4371-4377.
43. Furman RR, Forero-Torres A, Shustov A, Drachman JG,. A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia. Leuk Lymphoma 2010; 51: 228-235.