Human TNF-related apoptosis-inducing ligand-expressing dendritic cells from transgenic pigs attenuate human xenogeneic T cell responses

Xenotransplantation

Volumn 19, Issue 1, 2012, Pages 40-51

  Kemter, Elisabeth ^a   Lieke, Thorsten ^b   Kessler, Barbara ^a   Kurome, Mayuko ^a   Wuensch, Annegret ^a   Summerfield, Artur ^c   Ayares, David ^d   Nagashima, Hiroshi ^e   Baars, Wiebke ^b   Schwinzer, Reinhard ^b   Wolf, Eckhard ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (Switzerland)

^d REVIVICOR INC   (United States)

^e MEIJI UNIVERSITY   (Japan)

Author keywords

primary T cells; TNF related apoptosis inducing ligand; transgenic pigs; xenotransplantation

Indexed keywords

BETA ACTIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONFERENCE PAPER; CONTROLLED STUDY; CYTOMEGALOVIRUS; DENDRITIC CELL; ENHANCER REGION; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOMODULATION; KNOCKOUT GENE; LYMPHOCYTE PROLIFERATION; LYMPHOID TISSUE; LYMPHOMA CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROMOTER REGION; SPLEEN; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TISSUE DISTRIBUTION; TRANSGENIC ANIMAL; XENOGRAFT;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; DENDRITIC CELLS; HUMANS; JURKAT CELLS; LEUKOCYTES, MONONUCLEAR; SWINE; T-LYMPHOCYTES; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSPLANTATION, HETEROLOGOUS;

EID: 84857569876     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2011.00688.x     Document Type: Conference Paper

References (38)

1. Sachs DH,. The pig as a xenograft donor. Pathol Biol (Paris) 1994; 42: 217-219.
2. Schuurman H-J, Cheng J, Lam T,. Pathology of xenograft rejection: a commentary. Xenotransplantation 2003; 10: 293-299. (Pubitemid 36903769)
3. Bach FH, Robson SC, Winkler H, et al., Barriers to xenotransplantation. Nat Med 1995; 1: 869-873.
4. Dvorankova B, Broz L, Pafcuga I, Kapounkova Z, Konigova R,. The role of skin bank in the treatment of severely burnt patients. Acta Chir Plast 2004; 46: 51-55. (Pubitemid 39193909)
5. Habal MB,. Pig skin over open wounds. Surg Gynecol Obstet 1979; 149: 395. (Pubitemid 10220365)
6. Aigner B, Renner S, Kessler B, et al., Transgenic pigs as models for translational biomedical research. J Mol Med (Berl) 2010; 88: 653-664.
7. Lai L, Kolber-Simonds D, Park K-W, et al., Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 2002; 295: 1089-1092. (Pubitemid 34132242)
8. Phelps CJ, Koike C, Vaught TD, et al., Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 2003; 299: 411-414.
9. Klymiuk N, Aigner B, Brem G, Wolf E,. Genetic modification of pigs as organ donors for xenotransplantation. Mol Reprod Dev 2010; 77: 209-221.
10. Kuwaki K, Tseng Y-L, Dor FJMF, et al., Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med 2005; 11: 29-31. (Pubitemid 40215833)
11. Van Der Windt DJ, Bottino R, Casu A, et al., Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets. Am J Transplant 2009; 9: 2716-2726.
12. Yamada K, Sachs DH, Dersimonian H,. Human anti-porcine xenogeneic T cell response. Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition. J Immunol 1995; 155: 5249-5256.
13. Klose R, Kemter E, Bedke T, et al., Expression of biologically active human TRAIL in transgenic pigs. Transplantation 2005; 80: 222-230. (Pubitemid 41061679)
14. Kimberley FC, Screaton GR,. Following a TRAIL: update on a ligand and its five receptors. Cell Res 2004; 14: 359-372. (Pubitemid 43231798)
15. Giovarelli M, Musiani P, Garotta G, et al., A "stealth effect": adenocarcinoma cells engineered to express TRAIL elude tumor-specific and allogeneic T cell reactions. J Immunol 1999; 163: 4886-4893. (Pubitemid 29501253)
16. Strebel A, Bachmann F, Wernli M, Erb P,. Tumor necrosis factor-related, apoptosis-inducing ligand supports growth of mouse mastocytoma tumors by killing tumor-infiltrating macrophages. Int J Cancer 2002; 100: 627-634. (Pubitemid 34832971)
17. Schneider MR, Dahlhoff M, Herbach N, et al., Betacellulin overexpression in transgenic mice causes disproportionate growth, pulmonary hemorrhage syndrome, and complex eye pathology. Endocrinology 2005; 146: 5237-5246. (Pubitemid 41653037)
18. Kurome M, Ueda H, Tomii R, Naruse K, Nagashima H,. Production of transgenic-clone pigs by the combination of ICSI-mediated gene transfer with somatic cell nuclear transfer. Transgenic Res 2006; 15: 229-240.
19. Kaeffer B, Bottreau E, Phan Thanh L, Olivier M, Salmon H,. Histocompatible miniature, boar model: selection of transformed cell lines of B and T lineages producing retrovirus. Int J Cancer 1990; 46: 481-488. (Pubitemid 20291107)
20. Plege A, Borns K, Baars W, Schwinzer R,. Suppression of human T-cell activation and expansion of regulatory T cells by pig cells overexpressing PD-ligands. Transplantation 2009; 87: 975-982.
21. Lunemann JD, Waiczies S, Ehrlich S, et al., Death ligand TRAIL induces no apoptosis but inhibits activation of human (auto)antigen-specific T cells. J Immunol 2002; 168: 4881-4888. (Pubitemid 34495949)
22. Marsters SA, Pitti RM, Donahue CJ, Ruppert S, Bauer KD, Ashkenazi A,. Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA. Curr Biol 1996; 6: 750-752. (Pubitemid 126656342)
23. Bonenfant C, Vallee I, Sun J, et al., Analysis of human CD4 T lymphocyte proliferation induced by porcine lymphoblastoid B cell lines. Xenotransplantation 2003; 10: 107-119. (Pubitemid 36903781)
24. Petersen B, Ramackers W, Tiede A, et al., Pigs transgenic for human thrombomodulin have elevated production of activated protein C. Xenotransplantation 2009; 16: 486-495.
25. Schuurman H-J, Pierson RN 3rd,. Progress towards clinical xenotransplantation. Front Biosci 2008; 13: 204-220. (Pubitemid 351594772)
26. Weiss EH, Lilienfeld BG, Muller S, et al., HLA-E/human beta2-microglobulin transgenic pigs: protection against xenogeneic human anti-pig natural killer cell cytotoxicity. Transplantation 2009; 87: 35-43.
27. Martin C, Plat M, Nerriere-Daguin V, et al., Transgenic expression of CTLA4-Ig by fetal pig neurons for xenotransplantation. Transgenic Res 2005; 14: 373-384. (Pubitemid 41125388)
28. Phelps CJ, Ball SF, Vaught TD, et al., Production and characterization of transgenic pigs expressing porcine CTLA4-Ig. Xenotransplantation 2009; 16: 477-485.
29. Sato K, Nakaoka T, Yamashita N, et al., TRAIL-transduced dendritic cells protect mice from acute graft- vs.-host disease and leukemia relapse. J Immunol 2005; 174: 4025-4033. (Pubitemid 40395978)
30. Xie L, Shi W, Guo P,. Roles of tumor necrosis factor-related apoptosis-inducing ligand in corneal transplantation. Transplantation 2003; 76: 1556-1559. (Pubitemid 37549826)
31. Yang H-R, Hsieh C-C, Wang L, Fung JJ, Lu L, Qian S,. A critical role of TRAIL expressed on cotransplanted hepatic stellate cells in prevention of islet allograft rejection. Microsurgery 2010; 30: 332-337.
32. Jeremias I, Herr I, Boehler T, Debatin KM,. TRAIL/Apo-2-ligand-induced apoptosis in human T cells. Eur J Immunol 1998; 28: 143-152. (Pubitemid 28048285)
33. Song K, Chen Y, Goke R, et al., Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression. J Exp Med 2000; 191: 1095-1104.
34. + T cell killing of antigen-presenting macrophages. J Immunol 2000; 164: 2897-2904. (Pubitemid 30148946)
35. Hayakawa Y, Screpanti V, Yagita H, et al., NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy. J Immunol 2004; 172: 123-129. (Pubitemid 38020463)
36. Daigle I, Simon HU,. Alternative functions for TRAIL receptors in eosinophils and neutrophils. Swiss Med Wkly 2001; 131: 231-237. (Pubitemid 32480406)
37. Renshaw SA, Parmar JS, Singleton V, et al., Acceleration of human neutrophil apoptosis by TRAIL. J Immunol 2003; 170: 1027-1033. (Pubitemid 36070558)
38. Ursini-Siegel J, Zhang W, Altmeyer A, et al., TRAIL/Apo-2 ligand induces primary plasma cell apoptosis. J Immunol 2002; 169: 5505-5513. (Pubitemid 35291648)