Costimulation blockade in pig artery patch xenotransplantation - A simple model to monitor the adaptive immune response in nonhuman primates

Xenotransplantation

Volumn 19, Issue 4, 2012, Pages 221-232

  Ezzelarab, Mohamed B ^a   Ekser, Burcin ^a,b   Echeverri, Gabriel ^a,c   Hara, Hidetaka ^a   Ezzelarab, Corin ^a   Long, Cassandra ^a   Bajona, Pietro ^d   Garcia, Bertha ^e   Murase, Noriko ^a   Ayares, David ^f   Cooper, David K C ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF CATANIA   (Italy)

^c FUNDACIÓN VALLE DEL LILI   (Colombia)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF WESTERN ONTARIO   (Canada)

^f REVIVICOR INC   (United States)

Author keywords

1,3 galactosyltransferase gene knockout; anti CD154 monoclonal antibody; artery patch; costimulation blockade; CTLA4 Ig; pig; xenotransplantation

Indexed keywords

ABATACEPT; ABI 193; B7 ANTIGEN; CD28 ANTIGEN; CD40 LIGAND; CD40 LIGAND MONOCLONAL ANTIBODY; COBROTOXIN; GANCICLOVIR; HEPARIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; KETOROLAC; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY DETECTION; ANTIBODY RESPONSE; ARTERY GRAFT; ARTERY TRANSPLANTATION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CELL PROLIFERATION; COMPLEMENT DEPOSITION; CONTROLLED STUDY; EXPERIMENTAL PIG; GRAFT RECIPIENT; GRAFT SURVIVAL; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIMATE; PRIORITY JOURNAL; XENOGRAFT; XENOTRANSPLANTATION;

ADAPTIVE IMMUNITY; ANIMALS; ANTIGENS, HETEROPHILE; ARTERIES; CD40 LIGAND; GALACTOSYLTRANSFERASES; GENE KNOCKOUT TECHNIQUES; IMMUNITY, INNATE; IMMUNOSUPPRESSIVE AGENTS; MODELS, ANIMAL; MODELS, IMMUNOLOGICAL; PAPIO; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 84865391026     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2012.00711.x     Document Type: Article

References (28)

1. Phelps CJ, Koike C, Vaught TD, et al. Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 2003; 299: 411-414.
2. Kolber-Simonds D, Lai L, Watt SR, et al. Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations. Proc Natl Acad Sci USA 2004; 101: 7335-7340. (Pubitemid 38638033)
3. Kuwaki K, Tseng YL, Dor FJ, et al. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med 2005; 11: 29-31. (Pubitemid 40215833)
4. Tseng YL, Kuwaki K, Dor FJ, et al. alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months. Transplantation 2005; 80: 1493-1500. (Pubitemid 41803633)
5. Houser SL, Kuwaki K, Knosalla C, et al. Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons. Xenotransplantation 2004; 11: 416-425. (Pubitemid 39128211)
6. Chen G, Qian H, Starzl T, et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med 2005; 11: 1295-1298. (Pubitemid 41752909)
7. Ezzelarab M, Garcia B, Azimzadeh A, et al. The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients. Transplantation 2009; 87: 805-812.
8. Yamada K, Yazawa K, Shimizu A, et al. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3- galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med 2005; 11: 32-34. (Pubitemid 40215834)
9. Griesemer AD, Hirakata A, Shimizu A, et al. Results of gal-knockout porcine thymokidney xenografts. Am J Transplant 2009; 9: 2669-2678.
10. Vincenti F, Charpentier B, Vanrenterghem Y, et al. A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study). Am J Transplant 2010; 10: 535-546.
11. Dai Y, Vaught TD, Boone J, et al. Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs. Nat Biotechnol 2002; 20: 251-255. (Pubitemid 34205417)
12. Cooper DKC, Ye Y, Niekrasz M,. Heart transplantation in primates. In:, Cramer DV, Podesta LG, Makowka L, eds. Handbook of Animal Models in Transplantation Research. Boca Raton: CRC Press, 1994: 173-200.
13. Kozlowski T, Shimizu A, Lambrigts D, et al. Porcine kidney and heart transplantation in baboons undergoing a tolerance induction regimen and antibody adsorption. Transplantation 1999; 67: 18-30. (Pubitemid 29061132)
14. Buhler L, Yamada K, Kitamura H, et al. Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation. Transplantation 2001; 72: 1743-1752. (Pubitemid 33144227)
15. Knosalla C, Gollackner B, Cooper DK,. Anti-CD154 monoclonal antibody and thromboembolism revisted. Transplantation 2002; 74: 416-417.
16. Kuwaki K, Knosalla C, Dor FJ, et al. Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen. Am J Transplant 2004; 4: 363-372. (Pubitemid 38282291)
17. Kawai T, Andrews D, Colvin RB, Sachs DH, Cosimi AB,. Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand. Nat Med 2000; 6: 114. (Pubitemid 30082329)
18. Buhler L, Awwad M, Basker M, et al. High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response. Transplantation 2000; 69: 2296-2304. (Pubitemid 30408992)
19. Knosalla C, Gollackner B, Buhler L, et al. Correlation of biochemical and hematological changes with graft failure following pig heart and kidney transplantation in baboons. Am J Transplant 2003; 3: 1510-1519. (Pubitemid 37541508)
20. Lee RS, Yamada K, Womer KL, et al. Blockade of CD28-B7, but not CD40-CD154, prevents costimulation of allogeneic porcine and xenogeneic human anti-porcine T cell responses. J Immunol 2000; 164: 3434-3444. (Pubitemid 30149011)
21. Larsen CP, Pearson TC, Adams AB, et al. Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. Am J Transplant 2005; 5: 443-453. (Pubitemid 40313335)
22. Thompson P, Cardona K, Russell M, et al. CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates. Am J Transplant 2011; 11: 947-957.
23. Ekser B, Long C, Kumar G, et al. Heart transplantation using genetically-engineered pigs: can CTLA4-Ig replace anti-CD154mAb in the immunosuppressive regimen? (Abstract). Xenotransplantation 2011; 18: 284.
24. Ierino FL, Kozlowski T, Siegel JB, et al. Disseminated intravascular coagulation in association with the delayed rejection of pig-to-baboon renal xenografts. Transplantation 1998; 66: 1439-1450. (Pubitemid 29014022)
25. Buhler L, Basker M, Alwayn IP, et al. Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates. Transplantation 2000; 70: 1323-1331.
26. Robson SC, Cooper DK, D'Apice AJ,. Disordered regulation of coagulation and platelet activation in xenotransplantation. Xenotransplantation 2000; 7: 166-176.
27. Lin CC, Cooper DK, Dorling A,. Coagulation dysregulation as a barrier to xenotransplantation in the primate. Transpl Immunol 2009; 21: 75-80.
28. Kirk AD, Harlan DM, Armstrong NN, et al. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci USA 1997; 94: 8789-8794. (Pubitemid 27335118)