B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months

American Journal of Transplantation

Volumn 12, Issue 3, 2012, Pages 763-771

  Mohiuddin, M M ^a   Corcoran, P C ^a   Singh, A K ^a   Azimzadeh, A ^c   Hoyt Jr , R F ^a   Thomas, M L ^b   Eckhaus, M A ^b   Seavey, C ^a   Ayares, D ^d   Pierson III, R N ^c   Horvath, K A ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d REVIVICOR INC   (United States)

Author keywords

anti CD20; B cell depletion; CD46 transgenic; complement; Gal knockout pigs; xenoantibody; Xenograft

Indexed keywords

ANTIGEN; CD40 LIGAND; GALACTOSYLTRANSFERASE; MEMBRANE COFACTOR PROTEIN; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RITUXIMAB; THYMOCYTE ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; BABOON; FOLLOW UP; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE TREATMENT; MORBIDITY; NONHUMAN; PRIORITY JOURNAL; SWINE; XENOTRANSPLANTATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIBODY FORMATION; ANTIGENS, CD46; B-LYMPHOCYTES; FLOW CYTOMETRY; GALACTOSYLTRANSFERASES; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOSUPPRESSIVE AGENTS; PAPIO; SURVIVAL RATE; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 84857651619     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2011.03846.x     Document Type: Article

References (22)

1. Mulligan MS, Shearon TH, Weill D, Pagani FD, Moore J, Murray S,. Heart and lung transplantation in the United States, 1997-2006. Am J Transplant 2008; 8 (Pt 2): 977-987. (Pubitemid 351389065)
2. Badiwala MV, Rao V,. Left ventricular device as destination therapy: Are we there yet? Curr Opin Cardiol 2009; 24: 184-189.
3. Cozzi E, Bosio E, Seveso M, Vadori M, Ancona E,. Xenotransplantation- current status and future perspectives. Br Med Bull 2005; 75-76: 99-114.
4. Mohiuddin MM,. Clinical xenotransplantation of organs: Why aren't we there yet? PLoS Med 2007; 4: e75.
5. Schuurman HJ, Pierson RN, III,. Progress towards clinical xenotransplantation. Front Biosci 2008; 13: 204-20.
6. Chapman LE, Bloom ET,. Clinical xenotransplantation. JAMA 2001; 285: 2304-2306. (Pubitemid 32424090)
7. Cozzi E,. On the road to clinical xenotransplantation. Transplant Immunol 2009; 21: 57-59.
8. Daniels LJ, Platt JL,. Hyperacute xenograft rejection as an immunologic barrier to xenotransplantation. Kidney Int Suppl 1997; 58: S28-S35.
9. Adams DH, Kadner A, Chen RH, Farivar RS,. Human membrane cofactor protein (MCP, CD 46) protects transgenic pig hearts from hyperacute rejection in primates. Xenotransplantation. 2001; 8: 36-40. (Pubitemid 32127073)
10. Cooper DK, Ezzelarab M, Hara H, Ayares D,. Recent advances in pig-to-human organ and cell transplantation. Expert Opin Biol Ther 2008; 8: 1-4. (Pubitemid 351233718)
11. Sandrin MS, Loveland BE, McKenzie IF,. Genetic engineering for xenotransplantation. J Card Surg 2001; 16: 448-457. (Pubitemid 34242385)
12. Loveland BE, Milland J, Kyriakou P, et al,. Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons. Xenotransplantation 2004; 11: 171-183. (Pubitemid 38282268)
13. McGregor CG, Davies WR, Oi K, et al,. Cardiac xenotransplantation: recent preclinical progress with 3-month median survival. J Thorac Cardiovasc Surg 2005; 130: 844-851.
14. Wu G, Pfeiffer S, Schroder C, et al,. Co-stimulation blockade targeting CD154 and CD28/B7 modulates the induced antibody response after a pig-to-baboon cardiac xenograft. Xenotransplantation 2005; 12: 197-208. (Pubitemid 40524980)
15. Zhong R,. Gal knockout and beyond. Am J Transplant 2007; 7: 5-11. (Pubitemid 44952850)
16. Tseng YL, Moran K, Dor FJ, et al,. Elicited antibodies in baboons exposed to tissues from alpha1,3-galactosyltransferase gene-knockout pigs. Transplantation 2006; 81: 1058-1062. (Pubitemid 43670441)
17. Kuwaki K, Tseng YL, Dor FJ, et al,. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience. Nat Med 2005; 11: 29-31. (Pubitemid 40215833)
18. Nguyen BN, Azimzadeh AM, Schroeder C, et al,. Absence of Gal epitope prolongs survival of swine lungs in an ex vivo model of hyperacute rejection. Xenotransplantation 2011; 18: 94-107.
19. Corcoran PC, Horvath KA, Singh AK, et al,. Surgical and nonsurgical complications of a pig to baboon heterotopic heart transplantation model. Transplant Proc 2010; 42: 2149-2151.
20. Shimizu A, Hisashi Y, Kuwaki K, et al,. Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons. Am J Pathol 2008; 172: 1471-1481. (Pubitemid 351793341)
21. Ekser B, Kumar G, Veroux M, Cooper DK,. Therapeutic issues in the treatment of vascularized xenotransplants using gal-knockout donors in nonhuman primates. Curr Opin Organ Transplant. 2011; 16: 222-230.
22. Thompson P, Cardona K, Russell M, et al,. CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates. Am J Transplant 2011; 11: 947-957.