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Volumn 9, Issue 2, 2011, Pages 122-129

The immense potential of xenotransplantation in surgery

Author keywords

Cornea; Islets; Neuronal cells; Organs; Pig; Xenotransplantation

Indexed keywords

BLOOD CLOTTING; CELL TRANSPLANTATION; CORNEA TRANSPLANTATION; DIABETES MELLITUS; DISSEMINATED INTRAVASCULAR CLOTTING; DNA MODIFICATION; ERYTHROCYTE TRANSFUSION; GLYCEMIC CONTROL; HEART GRAFT; HUMAN; HUMORAL IMMUNITY; KIDNEY GRAFT; NONHUMAN; ORGAN INJURY; PANCREAS ISLET TRANSPLANTATION; PARKINSON DISEASE; PRIMATE; PRIORITY JOURNAL; REVIEW; SWINE; THROMBOCYTE ACTIVATION; THROMBOTIC THROMBOCYTOPENIC PURPURA; XENOTRANSPLANTATION;

EID: 79952107552     PISSN: 17439191     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijsu.2010.11.002     Document Type: Review
Times cited : (33)

References (92)
  • 3
    • 79952105538 scopus 로고    scopus 로고
    • Xenotransplantation - the future of corneal transplantation? Cornea. in press.
    • Hara H, Cooper DKC. Xenotransplantation - the future of corneal transplantation? Cornea. in press.
    • Hara, H.1    Cooper, D.K.C.2
  • 4
    • 0031025604 scopus 로고    scopus 로고
    • Clinical xenotransplantation - past, present and future
    • Taniguchi S., Cooper D.K.C. Clinical xenotransplantation - past, present and future. Ann R Coll Surg Engl 1997, 79:13-19.
    • (1997) Ann R Coll Surg Engl , vol.79 , pp. 13-19
    • Taniguchi, S.1    Cooper, D.K.C.2
  • 7
    • 0023950859 scopus 로고
    • Effects of cyclosporine and antibody adsorption on pig cardiac xenograft survival in the baboon
    • Cooper D.K.C., Human P.A., Lexer G., Rose A.G., Rees J., Keraan M., et al. Effects of cyclosporine and antibody adsorption on pig cardiac xenograft survival in the baboon. J Heart Transplant 1988, 7:238-246.
    • (1988) J Heart Transplant , vol.7 , pp. 238-246
    • Cooper, D.K.C.1    Human, P.A.2    Lexer, G.3    Rose, A.G.4    Rees, J.5    Keraan, M.6
  • 8
    • 65549162661 scopus 로고    scopus 로고
    • The innate immune response and activation of coagulation in α1,3-galactosyltransferase gene-knockout xenograft recipients
    • Ezzelarab M., Garcia B., Azimzadeh A., Sun H., Lin C.C., Hara H., et al. The innate immune response and activation of coagulation in α1,3-galactosyltransferase gene-knockout xenograft recipients. Transplantation 2009, 87:805-812.
    • (2009) Transplantation , vol.87 , pp. 805-812
    • Ezzelarab, M.1    Garcia, B.2    Azimzadeh, A.3    Sun, H.4    Lin, C.C.5    Hara, H.6
  • 9
    • 0028889431 scopus 로고
    • Human anti-porcine xenogeneic T cell response. Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition
    • Yamada K., Sachs D.H., DerSimonian H. Human anti-porcine xenogeneic T cell response. Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition. J Immunol 1995, 1(155):5249-5256.
    • (1995) J Immunol , vol.1 , Issue.155 , pp. 5249-5256
    • Yamada, K.1    Sachs, D.H.2    DerSimonian, H.3
  • 10
    • 58149330240 scopus 로고    scopus 로고
    • Suppressive efficacy and proliferative capacity of human regulatory T cells in allogeneic and xenogeneic responses
    • Lin Y.J., Hara H., Tai H.C., Long C., Tokita D., Yeh P., et al. Suppressive efficacy and proliferative capacity of human regulatory T cells in allogeneic and xenogeneic responses. Transplantation 2008, 86:1452-1462.
    • (2008) Transplantation , vol.86 , pp. 1452-1462
    • Lin, Y.J.1    Hara, H.2    Tai, H.C.3    Long, C.4    Tokita, D.5    Yeh, P.6
  • 11
    • 35748931149 scopus 로고    scopus 로고
    • Late onset of development of natural anti-nonGal antibodies in infant humans and baboons: implications for xenotransplantation in infants
    • Rood P.P.M., Tai H.C., Hara H., Long C., Ezzelarab M., Lin Y.J., et al. Late onset of development of natural anti-nonGal antibodies in infant humans and baboons: implications for xenotransplantation in infants. Transplant Int 2007, 20:1050-1058.
    • (2007) Transplant Int , vol.20 , pp. 1050-1058
    • Rood, P.P.M.1    Tai, H.C.2    Hara, H.3    Long, C.4    Ezzelarab, M.5    Lin, Y.J.6
  • 12
    • 0024297335 scopus 로고
    • Man, apes, and old world monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells
    • Galili U., Shohet S.B., Kobrin E., Stults C.L., Macher B.A. Man, apes, and old world monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells. J Biol Chem 1988, 263:17755-17762.
    • (1988) J Biol Chem , vol.263 , pp. 17755-17762
    • Galili, U.1    Shohet, S.B.2    Kobrin, E.3    Stults, C.L.4    Macher, B.A.5
  • 13
    • 0026623093 scopus 로고
    • Identification of carbohydrate structures that bind human antiporcine antibodies: implications for discordant xenografting in man
    • Good A.H., Cooper D.K.C., Malcolm A.J., Ippolito R.M., Koren E., Neethling F.A., et al. Identification of carbohydrate structures that bind human antiporcine antibodies: implications for discordant xenografting in man. Transplant Proc 1992, 24:559-562.
    • (1992) Transplant Proc , vol.24 , pp. 559-562
    • Good, A.H.1    Cooper, D.K.C.2    Malcolm, A.J.3    Ippolito, R.M.4    Koren, E.5    Neethling, F.A.6
  • 14
    • 0026770720 scopus 로고
    • Depletion of natural antibodies in non-human primates - a step towards successful discordant xenografting in man
    • Cooper D.K.C. Depletion of natural antibodies in non-human primates - a step towards successful discordant xenografting in man. Clin Transplantation 1992, 6:178-183.
    • (1992) Clin Transplantation , vol.6 , pp. 178-183
    • Cooper, D.K.C.1
  • 15
    • 0027135892 scopus 로고
    • Identification of α-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man
    • Cooper D.K.C., Good A.H., Koren E., Oriol R., Malcolm A.J., Ippolito R.M., et al. Identification of α-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man. Transpl Immunol 1993, 1:198-205.
    • (1993) Transpl Immunol , vol.1 , pp. 198-205
    • Cooper, D.K.C.1    Good, A.H.2    Koren, E.3    Oriol, R.4    Malcolm, A.J.5    Ippolito, R.M.6
  • 16
    • 0027716847 scopus 로고
    • Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation
    • Oriol R., Ye Y., Koren E., Cooper D.K.C. Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation. Transplantation 1993, 56:1433-1442.
    • (1993) Transplantation , vol.56 , pp. 1433-1442
    • Oriol, R.1    Ye, Y.2    Koren, E.3    Cooper, D.K.C.4
  • 17
    • 0025804969 scopus 로고
    • Histopathology of hyperacute rejection of the heart - experimental and clinical observation in allografts and xenografts
    • Rose A.G., Cooper D.K.C., Human P.A., Reichenspurner H., Reichart B. Histopathology of hyperacute rejection of the heart - experimental and clinical observation in allografts and xenografts. J Heart Transplant 1991, 10:223-234.
    • (1991) J Heart Transplant , vol.10 , pp. 223-234
    • Rose, A.G.1    Cooper, D.K.C.2    Human, P.A.3    Reichenspurner, H.4    Reichart, B.5
  • 18
    • 0029840618 scopus 로고    scopus 로고
    • A histopathologic grading system of hyperacute (humoral, antibody-mediated) cardiac xenograft and allograft rejection
    • Rose A.G., Cooper D.K.C. A histopathologic grading system of hyperacute (humoral, antibody-mediated) cardiac xenograft and allograft rejection. J Heart Lung Transplant 1996, 15:804-817.
    • (1996) J Heart Lung Transplant , vol.15 , pp. 804-817
    • Rose, A.G.1    Cooper, D.K.C.2
  • 19
    • 0034013386 scopus 로고    scopus 로고
    • Venular thrombosis is the key event in the pathogenesis of antibody-mediated cardiac rejection
    • Rose A.G., Cooper D.K.C. Venular thrombosis is the key event in the pathogenesis of antibody-mediated cardiac rejection. Xenotransplantation 2000, 7:31-41.
    • (2000) Xenotransplantation , vol.7 , pp. 31-41
    • Rose, A.G.1    Cooper, D.K.C.2
  • 20
    • 0025997675 scopus 로고
    • Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor. Potential for prevention of xenograft hyperacute rejection
    • Dalmasso A.P., Vercellotti G.M., Platt J.L., Bach F.H. Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor. Potential for prevention of xenograft hyperacute rejection. Transplantation 1991, 52:530-533.
    • (1991) Transplantation , vol.52 , pp. 530-533
    • Dalmasso, A.P.1    Vercellotti, G.M.2    Platt, J.L.3    Bach, F.H.4
  • 21
    • 0005595728 scopus 로고
    • Expression of human decay accelerating factor or membrane cofactor protein genes on mouse cells inhibits lysis by human complement
    • White D.J., Oglesby T., Liszewski M.K., Tedja I., Hourcade D., Wang M.W., et al. Expression of human decay accelerating factor or membrane cofactor protein genes on mouse cells inhibits lysis by human complement. Transpl Int 1992, 5:648-650.
    • (1992) Transpl Int , vol.5 , pp. 648-650
    • White, D.J.1    Oglesby, T.2    Liszewski, M.K.3    Tedja, I.4    Hourcade, D.5    Wang, M.W.6
  • 22
    • 0029068597 scopus 로고
    • The generation of transgenic pigs as potential organ donors for humans
    • Cozzi E., White D.J.G. The generation of transgenic pigs as potential organ donors for humans. Nat Med 1995, 1:964-969.
    • (1995) Nat Med , vol.1 , pp. 964-969
    • Cozzi, E.1    White, D.J.G.2
  • 23
    • 10744224843 scopus 로고    scopus 로고
    • Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons
    • Loveland B.E., Milland J., Kyriakou P., Thorley B.R., Christiansen D., Lanteri M.B., et al. Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons. Xenotransplantation 2004, 11:171-183.
    • (2004) Xenotransplantation , vol.11 , pp. 171-183
    • Loveland, B.E.1    Milland, J.2    Kyriakou, P.3    Thorley, B.R.4    Christiansen, D.5    Lanteri, M.B.6
  • 25
    • 0031014159 scopus 로고    scopus 로고
    • Transgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damage
    • Byrne G.W., McCurry K.R., Martin M.J., McClellan S.M., Platt J.L., Logan J.S. Transgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damage. Transplantation 1997, 63:149-155.
    • (1997) Transplantation , vol.63 , pp. 149-155
    • Byrne, G.W.1    McCurry, K.R.2    Martin, M.J.3    McClellan, S.M.4    Platt, J.L.5    Logan, J.S.6
  • 26
    • 18544404547 scopus 로고    scopus 로고
    • Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons
    • Cowan P.J., Aminian A., Barlow H., Brown A.A., Chen C.G., Fisicaro N., et al. Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons. Transplantation 2000, 69:2504-2515.
    • (2000) Transplantation , vol.69 , pp. 2504-2515
    • Cowan, P.J.1    Aminian, A.2    Barlow, H.3    Brown, A.A.4    Chen, C.G.5    Fisicaro, N.6
  • 27
    • 55649120266 scopus 로고    scopus 로고
    • In vitro investigation of pig cells for resistance to human antibody-mediated rejection
    • Hara H., Long C., Lin Y.J., Tai H.C., Ezzelarab M., Ayares D., et al. In vitro investigation of pig cells for resistance to human antibody-mediated rejection. Transplant Int 2008, 21:1163-1174.
    • (2008) Transplant Int , vol.21 , pp. 1163-1174
    • Hara, H.1    Long, C.2    Lin, Y.J.3    Tai, H.C.4    Ezzelarab, M.5    Ayares, D.6
  • 28
    • 0027237845 scopus 로고
    • Genetically engineered pigs
    • Cooper D.K.C., Koren E., Oriol R. Genetically engineered pigs. Lancet 1993, 342:682-683.
    • (1993) Lancet , vol.342 , pp. 682-683
    • Cooper, D.K.C.1    Koren, E.2    Oriol, R.3
  • 30
    • 2442567900 scopus 로고    scopus 로고
    • Production of α1,3-galactosyltransferase null pigs via nuclear transfer with fibroblasts bearing loss of heterozygosity mutations
    • Kolber-Simonds D., Lai L., Watt S.R., Denaro M., Arn S., Augenstein M.L., et al. Production of α1,3-galactosyltransferase null pigs via nuclear transfer with fibroblasts bearing loss of heterozygosity mutations. Proc Natl Acad Sci USA 2004, 19:7335-7340.
    • (2004) Proc Natl Acad Sci USA , vol.19 , pp. 7335-7340
    • Kolber-Simonds, D.1    Lai, L.2    Watt, S.R.3    Denaro, M.4    Arn, S.5    Augenstein, M.L.6
  • 31
    • 13444282227 scopus 로고    scopus 로고
    • Heart transplantation in baboons using α1,3-galactosyltransferase gene-knockout pigs as donors:initial experience
    • Kuwaki K., Tseng Y.L., Dor F.J., Shimizu A., Houser S.L., Sanderson T.M., et al. Heart transplantation in baboons using α1,3-galactosyltransferase gene-knockout pigs as donors:initial experience. Nat Med 2005, 11:29-31.
    • (2005) Nat Med , vol.11 , pp. 29-31
    • Kuwaki, K.1    Tseng, Y.L.2    Dor, F.J.3    Shimizu, A.4    Houser, S.L.5    Sanderson, T.M.6
  • 32
    • 29144436254 scopus 로고    scopus 로고
    • α 1,3-galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching six months
    • Tseng Y.L., Kuwaki K., Dor F.J., Shimizu A., Houser S., Hisashi Y., et al. α 1,3-galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching six months. Transplantation 2005, 80:1493-1500.
    • (2005) Transplantation , vol.80 , pp. 1493-1500
    • Tseng, Y.L.1    Kuwaki, K.2    Dor, F.J.3    Shimizu, A.4    Houser, S.5    Hisashi, Y.6
  • 33
    • 13444269248 scopus 로고    scopus 로고
    • Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
    • Yamada K., Yazawa K., Shimizu A., Iwanaga T., Hisashi Y., Nuhn M., et al. Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med 2005, 11:32-34.
    • (2005) Nat Med , vol.11 , pp. 32-34
    • Yamada, K.1    Yazawa, K.2    Shimizu, A.3    Iwanaga, T.4    Hisashi, Y.5    Nuhn, M.6
  • 34
    • 33745094078 scopus 로고    scopus 로고
    • Allosensitized humans are at no greater risk of humoral rejection of GT-KO pig organs than other humans
    • Hara H., Ezzelarab M., Rood P.P.M., Lin Y.J., Busch J., Ibrahim Z., et al. Allosensitized humans are at no greater risk of humoral rejection of GT-KO pig organs than other humans. Xenotransplantation 2006, 13:357-365.
    • (2006) Xenotransplantation , vol.13 , pp. 357-365
    • Hara, H.1    Ezzelarab, M.2    Rood, P.P.M.3    Lin, Y.J.4    Busch, J.5    Ibrahim, Z.6
  • 35
    • 33747603670 scopus 로고    scopus 로고
    • Antibodies directed to pig nonGal antigens in naïve and sensitized baboons
    • Ezzelarab M., Hara H., Busch J., Rood P.P., Zhu X., Ibrahim Z., et al. Antibodies directed to pig nonGal antigens in naïve and sensitized baboons. Xenotransplantation 2006, 13:400-407.
    • (2006) Xenotransplantation , vol.13 , pp. 400-407
    • Ezzelarab, M.1    Hara, H.2    Busch, J.3    Rood, P.P.4    Zhu, X.5    Ibrahim, Z.6
  • 36
    • 33645365768 scopus 로고    scopus 로고
    • Incidence and cytotoxicity of antibodies in cynomolgus monkeys directed to nonGal antigens, and their relevance for experimental models
    • Rood P.P.M., Hara H., Busch J.L., Ezzelarab M., Zhu X., Ball S., et al. Incidence and cytotoxicity of antibodies in cynomolgus monkeys directed to nonGal antigens, and their relevance for experimental models. Transpl Int 2006, 19:158-165.
    • (2006) Transpl Int , vol.19 , pp. 158-165
    • Rood, P.P.M.1    Hara, H.2    Busch, J.L.3    Ezzelarab, M.4    Zhu, X.5    Ball, S.6
  • 37
    • 77953514286 scopus 로고    scopus 로고
    • Investigation of potential carbohydrate antigen targets for human and baboon antibodies
    • Yeh P., Ezzelarab M., Bovin N., Hara H., Long C., Tomiyama K., et al. Investigation of potential carbohydrate antigen targets for human and baboon antibodies. Xenotransplantation 2010, 17:197-206.
    • (2010) Xenotransplantation , vol.17 , pp. 197-206
    • Yeh, P.1    Ezzelarab, M.2    Bovin, N.3    Hara, H.4    Long, C.5    Tomiyama, K.6
  • 38
    • 79952102077 scopus 로고    scopus 로고
    • Early graft failure of GTKO pig organs in baboons is reduced by HCPRP expression
    • (Abstract 499)
    • Azimzadeh A.M., Kelishadi S., Ezzelarab M., Singh A.K., Stoddard T., Zhang T., et al. Early graft failure of GTKO pig organs in baboons is reduced by HCPRP expression. Am J Transplant 2010, 10(Suppl. 4):186. (Abstract 499).
    • (2010) Am J Transplant , vol.10 , Issue.SUPPL. 4 , pp. 186
    • Azimzadeh, A.M.1    Kelishadi, S.2    Ezzelarab, M.3    Singh, A.K.4    Stoddard, T.5    Zhang, T.6
  • 39
    • 28644446730 scopus 로고    scopus 로고
    • Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys
    • Chen G., Qian H., Starzl T., Sun H., Garcia B., Wang X., et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med 2005, 11:1295-1298.
    • (2005) Nat Med , vol.11 , pp. 1295-1298
    • Chen, G.1    Qian, H.2    Starzl, T.3    Sun, H.4    Garcia, B.5    Wang, X.6
  • 41
    • 79952106203 scopus 로고    scopus 로고
    • Dominant-negative CIITA transgenic pigs - effect on the human anti-pig T cell immune response and immune status
    • Abstract 503
    • Hara H., Crossley T., Witt W., Long C., Fang J., Ezzelarab M., et al. Dominant-negative CIITA transgenic pigs - effect on the human anti-pig T cell immune response and immune status. Am J Transplant 2010, 10(Suppl. 4):187. Abstract 503.
    • (2010) Am J Transplant , vol.10 , Issue.SUPPL. 4 , pp. 187
    • Hara, H.1    Crossley, T.2    Witt, W.3    Long, C.4    Fang, J.5    Ezzelarab, M.6
  • 42
    • 10744228498 scopus 로고    scopus 로고
    • Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-CD154 monoclonal antibody-based regimen
    • Kuwaki K., Knosalla C., Dor F.J., Gollackner B., Tseng Y.L., Houser S., et al. Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-CD154 monoclonal antibody-based regimen. Transplant 2004, 4:363-372.
    • (2004) Transplant , vol.4 , pp. 363-372
    • Kuwaki, K.1    Knosalla, C.2    Dor, F.J.3    Gollackner, B.4    Tseng, Y.L.5    Houser, S.6
  • 43
    • 0032535196 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation in association with the delayed rejection of pig-to-baboon renal xenografts
    • Ierino F.L., Kozlowski T., Siegel J.B., Shimizu A., Colvin R.B., Banerjee P.T., et al. Disseminated intravascular coagulation in association with the delayed rejection of pig-to-baboon renal xenografts. Transplantation 1998, 66:1439-1450.
    • (1998) Transplantation , vol.66 , pp. 1439-1450
    • Ierino, F.L.1    Kozlowski, T.2    Siegel, J.B.3    Shimizu, A.4    Colvin, R.B.5    Banerjee, P.T.6
  • 44
    • 0033556459 scopus 로고    scopus 로고
    • Porcine kidney and heart transplantation in baboons undergoing a tolerance induction regimen and antibody adsorption
    • Kozlowski T., Shimizu A., Lambrigts D., Yamada K., Fuchimoto Y., Glaser R., et al. Porcine kidney and heart transplantation in baboons undergoing a tolerance induction regimen and antibody adsorption. Transplantation 1999, 67:18-30.
    • (1999) Transplantation , vol.67 , pp. 18-30
    • Kozlowski, T.1    Shimizu, A.2    Lambrigts, D.3    Yamada, K.4    Fuchimoto, Y.5    Glaser, R.6
  • 45
    • 0034669536 scopus 로고    scopus 로고
    • Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates
    • Bühler L., Basker M., Alwayn I.P., Goepfert C., Kitamura H., Kawai T., et al. Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates. Transplantation 2000, 70:1323-1331.
    • (2000) Transplantation , vol.70 , pp. 1323-1331
    • Bühler, L.1    Basker, M.2    Alwayn, I.P.3    Goepfert, C.4    Kitamura, H.5    Kawai, T.6
  • 46
    • 77954079584 scopus 로고    scopus 로고
    • Tissue factor expression on recipient platelets is associated with consumptive coagulopathy in pig-to-primate kidney xenotransplantation
    • Lin C.C., Ezzelarab M., Shapiro R., Ekser B., Long C., Hara H., et al. Tissue factor expression on recipient platelets is associated with consumptive coagulopathy in pig-to-primate kidney xenotransplantation. Am J Transplant 2010, 10:1556-1568.
    • (2010) Am J Transplant , vol.10 , pp. 1556-1568
    • Lin, C.C.1    Ezzelarab, M.2    Shapiro, R.3    Ekser, B.4    Long, C.5    Hara, H.6
  • 47
    • 65249148546 scopus 로고    scopus 로고
    • Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation
    • Knosalla C., Yazawa K., Behdad A., Bodyak N., Shang H., Bühler L., et al. Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation. Am J Transplant 2009, 9:1006-1016.
    • (2009) Am J Transplant , vol.9 , pp. 1006-1016
    • Knosalla, C.1    Yazawa, K.2    Behdad, A.3    Bodyak, N.4    Shang, H.5    Bühler, L.6
  • 49
    • 2942661758 scopus 로고    scopus 로고
    • Acute vascular rejection of xenografts:roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity
    • Gollackner B., GohSK Qawi I., Buhler L., Knosalla C., Daniel S., et al. Acute vascular rejection of xenografts:roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity. Transplantation 2004, 77:1735-1741.
    • (2004) Transplantation , vol.77 , pp. 1735-1741
    • Gollackner, B.1    Goh, S.K.2    Qawi, I.3    Buhler, L.4    Knosalla, C.5    Daniel, S.6
  • 50
    • 0033806674 scopus 로고    scopus 로고
    • Disordered regulation of coagulation and platelet activation in xenotransplantation
    • Robson S.C., Cooper D.K.C., d'Apice A.J.F. Disordered regulation of coagulation and platelet activation in xenotransplantation. Xenotransplantation 2000, 7:166-176.
    • (2000) Xenotransplantation , vol.7 , pp. 166-176
    • Robson, S.C.1    Cooper, D.K.C.2    d'Apice, A.J.F.3
  • 51
    • 0035753428 scopus 로고    scopus 로고
    • Molecular incompatibilities in hemostasis between swine and men-impact on xenografting
    • Schulte am Esch J., Rogiers X., Robson S.C. Molecular incompatibilities in hemostasis between swine and men-impact on xenografting. Ann Transplant 2001, 6:12-16.
    • (2001) Ann Transplant , vol.6 , pp. 12-16
    • Schulte am Esch, J.1    Rogiers, X.2    Robson, S.C.3
  • 52
    • 33845994431 scopus 로고    scopus 로고
    • Coagulation and the xenograft endothelium
    • Cowan P.J. Coagulation and the xenograft endothelium. Xenotransplantation 2007, 14:7-12.
    • (2007) Xenotransplantation , vol.14 , pp. 7-12
    • Cowan, P.J.1
  • 54
    • 4344688865 scopus 로고    scopus 로고
    • Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons
    • Houser S.L., Kuwaki K., Knosalla C., Dor F.J., Gollackner B., Cheng J., et al. Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons. Xenotransplantation 2004, 11:416-425.
    • (2004) Xenotransplantation , vol.11 , pp. 416-425
    • Houser, S.L.1    Kuwaki, K.2    Knosalla, C.3    Dor, F.J.4    Gollackner, B.5    Cheng, J.6
  • 55
    • 33747127485 scopus 로고    scopus 로고
    • Allosensitization does not increase the risk of xenoreactivity to Ά1,3-Galactosyltransferase gene-knockout (GalT-KO) miniature swine in patients on transplantation waiting lists
    • Wong B.S., Yamada K., Koumi M., Weiner J., O'Malley P.E., Tseng Y.L., et al. Allosensitization does not increase the risk of xenoreactivity to Ά1,3-Galactosyltransferase gene-knockout (GalT-KO) miniature swine in patients on transplantation waiting lists. Transplantation 2006, 82:314-319.
    • (2006) Transplantation , vol.82 , pp. 314-319
    • Wong, B.S.1    Yamada, K.2    Koumi, M.3    Weiner, J.4    O'Malley, P.E.5    Tseng, Y.L.6
  • 56
    • 1642443483 scopus 로고    scopus 로고
    • Allo- and xeno-antibody cross-reactivity in transplantation
    • Cooper D.K.C., Tseng Y.L., Saidman S.L. Allo- and xeno-antibody cross-reactivity in transplantation. Transplantation 2004, 77:1-5.
    • (2004) Transplantation , vol.77 , pp. 1-5
    • Cooper, D.K.C.1    Tseng, Y.L.2    Saidman, S.L.3
  • 57
    • 79952107455 scopus 로고    scopus 로고
    • Pig to baboon cardiac xenotransplantation:essential role of B cell depletion in prolonging cardiac xenograft survival
    • (Abstract 498)
    • Mohiuddin M.M., Corcoran P.C., Singh A.K., Hoyt R.F., Thomas M.L., Eckhaus M.A., et al. Pig to baboon cardiac xenotransplantation:essential role of B cell depletion in prolonging cardiac xenograft survival. Am J Transplant 2010, 10(Suppl. 4):186. (Abstract 498).
    • (2010) Am J Transplant , vol.10 , Issue.SUPPL. 4 , pp. 186
    • Mohiuddin, M.M.1    Corcoran, P.C.2    Singh, A.K.3    Hoyt, R.F.4    Thomas, M.L.5    Eckhaus, M.A.6
  • 58
    • 77955711715 scopus 로고    scopus 로고
    • Early cardiac function and gene expression after orthotopic cardiac xenotransplantation
    • (Abstract IXA-O-2.4)
    • McGregor C.G.A., Byrne G.W., Vlasin M., Walker R.C., Tazelaar H.D., Davies W.R., et al. Early cardiac function and gene expression after orthotopic cardiac xenotransplantation. Xenotransplantation 2009, 16:356. (Abstract IXA-O-2.4).
    • (2009) Xenotransplantation , vol.16 , pp. 356
    • McGregor, C.G.A.1    Byrne, G.W.2    Vlasin, M.3    Walker, R.C.4    Tazelaar, H.D.5    Davies, W.R.6
  • 59
    • 10744227988 scopus 로고    scopus 로고
    • Maintenance triple immunosuppression with cyclosporin A, mycophenolate sodium and steroids allows prolonged survival of primate recipients of hDAF porcine renal xenografts
    • Cozzi E., Vial C., Ostlie D., Farah B., Chavez G., Smith K.G., et al. Maintenance triple immunosuppression with cyclosporin A, mycophenolate sodium and steroids allows prolonged survival of primate recipients of hDAF porcine renal xenografts. Xenotransplantation 2003, 10:300-310.
    • (2003) Xenotransplantation , vol.10 , pp. 300-310
    • Cozzi, E.1    Vial, C.2    Ostlie, D.3    Farah, B.4    Chavez, G.5    Smith, K.G.6
  • 61
    • 75149191343 scopus 로고    scopus 로고
    • Impact of thrombocytopenia on survival of baboons with genetically-modified pig liver transplants:clinical relevance
    • Ekser B., Long C., Echeverri G.J., Hara H., Ezzelarab M., Lin C.C., et al. Impact of thrombocytopenia on survival of baboons with genetically-modified pig liver transplants:clinical relevance. Am J Transplant 2010, 10:273-285.
    • (2010) Am J Transplant , vol.10 , pp. 273-285
    • Ekser, B.1    Long, C.2    Echeverri, G.J.3    Hara, H.4    Ezzelarab, M.5    Lin, C.C.6
  • 62
    • 20144389921 scopus 로고    scopus 로고
    • Hyperacute rejection is attenuated in GalTKO swine lungs perfused ex vivo with human blood
    • Schroeder C., Allan J.S., Nguyen B.N., Wu G., Zhang T., Azimzadeh A.M., et al. Hyperacute rejection is attenuated in GalTKO swine lungs perfused ex vivo with human blood. Transplant Proc 2005, 37:512-513.
    • (2005) Transplant Proc , vol.37 , pp. 512-513
    • Schroeder, C.1    Allan, J.S.2    Nguyen, B.N.3    Wu, G.4    Zhang, T.5    Azimzadeh, A.M.6
  • 65
    • 33750095969 scopus 로고    scopus 로고
    • Selected physiologic compatibilities and incompatibilities between human and porcine organ systems
    • Ibrahim Z., Busch J., Awwad M., Wagner R., Wells K., Cooper D.K.C. Selected physiologic compatibilities and incompatibilities between human and porcine organ systems. Xenotransplantation 2006, 13:488-499.
    • (2006) Xenotransplantation , vol.13 , pp. 488-499
    • Ibrahim, Z.1    Busch, J.2    Awwad, M.3    Wagner, R.4    Wells, K.5    Cooper, D.K.C.6
  • 67
    • 33644831338 scopus 로고    scopus 로고
    • Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates
    • Hering B.J., Wijkstrom M., Graham M.L., Hårdstedt M., Aasheim T.C., Jie T., et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 2006, 12:301-303.
    • (2006) Nat Med , vol.12 , pp. 301-303
    • Hering, B.J.1    Wijkstrom, M.2    Graham, M.L.3    Hårdstedt, M.4    Aasheim, T.C.5    Jie, T.6
  • 68
    • 33644829825 scopus 로고    scopus 로고
    • Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways
    • Cardona K., Korbutt G.S., Milas Z., Lyon J., Cano J., Jiang W., et al. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med 2006, 12:304-306.
    • (2006) Nat Med , vol.12 , pp. 304-306
    • Cardona, K.1    Korbutt, G.S.2    Milas, Z.3    Lyon, J.4    Cano, J.5    Jiang, W.6
  • 69
    • 33744496021 scopus 로고    scopus 로고
    • Six-month survival of microencapsulated pig islets and alginate biocompatibility in primates:proof of concept
    • Dufrane D., Goebbels R.M., Saliez A., Gulot Y., Gianello P. Six-month survival of microencapsulated pig islets and alginate biocompatibility in primates:proof of concept. Transplantation 2006, 81:1345-1353.
    • (2006) Transplantation , vol.81 , pp. 1345-1353
    • Dufrane, D.1    Goebbels, R.M.2    Saliez, A.3    Gulot, Y.4    Gianello, P.5
  • 70
    • 70349706907 scopus 로고    scopus 로고
    • Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets
    • van der Windt D.J., Bottino R., Casu A., Campanile N., Smetanka C., He J., et al. Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets. Am J Transplant 2009, 9:2716-2726.
    • (2009) Am J Transplant , vol.9 , pp. 2716-2726
    • van der Windt, D.J.1    Bottino, R.2    Casu, A.3    Campanile, N.4    Smetanka, C.5    He, J.6
  • 71
    • 0034653591 scopus 로고    scopus 로고
    • Damage to porcine islets of langerhans after exposure to human blood in vitro, or after intraportal transplantation to cynomologus monkeys:protective effects of sCR1 and heparin
    • Bennet W., Sundberg B., Lundgren T., Tibell A., Groth C.G., Richards A., et al. Damage to porcine islets of langerhans after exposure to human blood in vitro, or after intraportal transplantation to cynomologus monkeys:protective effects of sCR1 and heparin. Transplantation 2000, 69:711-719.
    • (2000) Transplantation , vol.69 , pp. 711-719
    • Bennet, W.1    Sundberg, B.2    Lundgren, T.3    Tibell, A.4    Groth, C.G.5    Richards, A.6
  • 73
    • 0032803512 scopus 로고    scopus 로고
    • Potential application of neonatal porcine islets as treatment for type 1 diabetes:a review
    • Rayat G.R., Rajotte R.V., Korbutt G.S. Potential application of neonatal porcine islets as treatment for type 1 diabetes:a review. Ann N Y Acad Sci 1999, 18:175-188.
    • (1999) Ann N Y Acad Sci , vol.18 , pp. 175-188
    • Rayat, G.R.1    Rajotte, R.V.2    Korbutt, G.S.3
  • 74
    • 36649032233 scopus 로고    scopus 로고
    • Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice
    • Casu A., Bottino R., Balamurugan A.N., Hara H., van der Windt D.J., Campanile N., et al. Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice. Diabetologia 2008, 51:120-129.
    • (2008) Diabetologia , vol.51 , pp. 120-129
    • Casu, A.1    Bottino, R.2    Balamurugan, A.N.3    Hara, H.4    van der Windt, D.J.5    Campanile, N.6
  • 75
    • 35948946174 scopus 로고    scopus 로고
    • WZS-pig is a potential donor alternative in corneal xenotransplantation
    • Pan Z., Sun C., Jie Y., Wang N., Wang L. WZS-pig is a potential donor alternative in corneal xenotransplantation. Xenotransplantation 2007, 14:603-611.
    • (2007) Xenotransplantation , vol.14 , pp. 603-611
    • Pan, Z.1    Sun, C.2    Jie, Y.3    Wang, N.4    Wang, L.5
  • 76
    • 61849113219 scopus 로고    scopus 로고
    • Histological differences in full-thickness vs. lamellar corneal pig-to-rabbit xenotransplantation
    • Oh J.Y., Kim M.K., Ko J.H., Lee H.J., Park C.G., Kim S.J., et al. Histological differences in full-thickness vs. lamellar corneal pig-to-rabbit xenotransplantation. Vet Ophthalmol 2009, 12:78-82.
    • (2009) Vet Ophthalmol , vol.12 , pp. 78-82
    • Oh, J.Y.1    Kim, M.K.2    Ko, J.H.3    Lee, H.J.4    Park, C.G.5    Kim, S.J.6
  • 77
    • 79952103362 scopus 로고    scopus 로고
    • et al. Initial in vitro investigation of the human immune response to corneal cells from genetically-engineered pigs, [Submitted for publication].
    • Hara H, Koike N, Long C, Piluex J, Roh DS, Sundarraj N, et al. Initial in vitro investigation of the human immune response to corneal cells from genetically-engineered pigs. 2010. [Submitted for publication].
    • (2010)
    • Hara, H.1    Koike, N.2    Long, C.3    Piluex, J.4    Roh, D.S.5    Sundarraj, N.6
  • 78
    • 79952101937 scopus 로고    scopus 로고
    • Porcine embryonic xenografts transgenic for CTLA4-Ig enable longterm recovery in Parkinsonian macaques
    • (Abstract LB01)
    • Badin R.A., Padoan A., Vadori M., Boldrin M., De Benedictis G.M., Fante F., et al. Porcine embryonic xenografts transgenic for CTLA4-Ig enable longterm recovery in Parkinsonian macaques. Am J Transplant 2010, 10(Suppl. 4):208. (Abstract LB01).
    • (2010) Am J Transplant , vol.10 , Issue.SUPPL. 4 , pp. 208
    • Badin, R.A.1    Padoan, A.2    Vadori, M.3    Boldrin, M.4    De Benedictis, G.M.5    Fante, F.6
  • 79
    • 0034037185 scopus 로고    scopus 로고
    • Introduction to porcine red cells;implications for xenotransplantation
    • Zhu A. Introduction to porcine red cells;implications for xenotransplantation. Sem Hematol 2000, 37:143-149.
    • (2000) Sem Hematol , vol.37 , pp. 143-149
    • Zhu, A.1
  • 80
    • 77953329303 scopus 로고    scopus 로고
    • Genetically-engineered pigs as a source for clinical red blood cell transfusion
    • Cooper D.K.C., Hara H., Yazer M. Genetically-engineered pigs as a source for clinical red blood cell transfusion. Clin Lab Med 2010, 30:365-380.
    • (2010) Clin Lab Med , vol.30 , pp. 365-380
    • Cooper, D.K.C.1    Hara, H.2    Yazer, M.3
  • 81
    • 0141855067 scopus 로고    scopus 로고
    • Porcine red blood cells as a source of blood transfusion in humans
    • Cooper D.K.C. Porcine red blood cells as a source of blood transfusion in humans. Xenotransplantation 2003, 10:384-385.
    • (2003) Xenotransplantation , vol.10 , pp. 384-385
    • Cooper, D.K.C.1
  • 82
    • 70449101282 scopus 로고    scopus 로고
    • Genetically-engineered pig red blood cells for clinical transfusion:initial in vitro studies
    • Long C., Hara H., Pawlikowski Z., Koike N., d'Arville T., Yeh P., et al. Genetically-engineered pig red blood cells for clinical transfusion:initial in vitro studies. Transfusion 2009, 49:2418-2429.
    • (2009) Transfusion , vol.49 , pp. 2418-2429
    • Long, C.1    Hara, H.2    Pawlikowski, Z.3    Koike, N.4    d'Arville, T.5    Yeh, P.6
  • 84
    • 4344669147 scopus 로고    scopus 로고
    • Xenotransplantation:infectious risk revisited
    • Fishman J.A., Patience C. Xenotransplantation:infectious risk revisited. Am J Transplant 2004, 4:1383-1390.
    • (2004) Am J Transplant , vol.4 , pp. 1383-1390
    • Fishman, J.A.1    Patience, C.2
  • 85
    • 33847612935 scopus 로고    scopus 로고
    • Inhibition of porcine endogenous retroviruses (PERVs) in primary porcine cells by RNA interference using lentiviral vectors
    • Dieckhoff B., Karlas A., Hofmann A., Kues W.A., Petersen B., Pfeifer A., et al. Inhibition of porcine endogenous retroviruses (PERVs) in primary porcine cells by RNA interference using lentiviral vectors. Arch Virol 2007, 152:629-634.
    • (2007) Arch Virol , vol.152 , pp. 629-634
    • Dieckhoff, B.1    Karlas, A.2    Hofmann, A.3    Kues, W.A.4    Petersen, B.5    Pfeifer, A.6
  • 86
    • 40549093335 scopus 로고    scopus 로고
    • Knockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs
    • Dieckhoff B., Petersen B., Kues W.A., Kurth R., Niemann H., Denner J. Knockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs. Xenotransplantation 2008, 15:36-45.
    • (2008) Xenotransplantation , vol.15 , pp. 36-45
    • Dieckhoff, B.1    Petersen, B.2    Kues, W.A.3    Kurth, R.4    Niemann, H.5    Denner, J.6
  • 87
    • 67651160600 scopus 로고    scopus 로고
    • Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs
    • Ramsoondar J., Vaught T., Ball S., Mendicino M., Monahan J., Jobst P., et al. Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs. Xenotransplantation 2009, 16:164-180.
    • (2009) Xenotransplantation , vol.16 , pp. 164-180
    • Ramsoondar, J.1    Vaught, T.2    Ball, S.3    Mendicino, M.4    Monahan, J.5    Jobst, P.6
  • 88
    • 4944229594 scopus 로고    scopus 로고
    • Xenotransplantation-clinical activities and regulatory development
    • Tibell A., Lundgren T. Xenotransplantation-clinical activities and regulatory development. Acta Vet Scand 2004, 99(Suppl.):19-23.
    • (2004) Acta Vet Scand , vol.99 , Issue.SUPPL. , pp. 19-23
    • Tibell, A.1    Lundgren, T.2
  • 89
    • 42649120673 scopus 로고    scopus 로고
    • Regulatory aspects of pig-to-human islet transplantation
    • Schuurman H.J. Regulatory aspects of pig-to-human islet transplantation. Xenotransplantation 2008, 15:116-120.
    • (2008) Xenotransplantation , vol.15 , pp. 116-120
    • Schuurman, H.J.1
  • 90
    • 66149128857 scopus 로고    scopus 로고
    • First WHO global consultation on regulatory requirements for xenotransplantation clinical trials, Changsha, China, 19-21 November 2008
    • The Changsha Communiqué, World Health Organization
    • World Health Organization First WHO global consultation on regulatory requirements for xenotransplantation clinical trials, Changsha, China, 19-21 November 2008. Xenotransplantation 2009, 16:58-60. The Changsha Communiqué.
    • (2009) Xenotransplantation , vol.16 , pp. 58-60
  • 91
    • 7944223995 scopus 로고    scopus 로고
    • IXA ethics committee. position paper of the ethics committee of the international xenotransplantation association
    • Sykes M., d'Apice A., Sandrin M. IXA ethics committee. position paper of the ethics committee of the international xenotransplantation association. Transplantation 2004, 78:1101-1107.
    • (2004) Transplantation , vol.78 , pp. 1101-1107
    • Sykes, M.1    d'Apice, A.2    Sandrin, M.3
  • 92
    • 71649103889 scopus 로고    scopus 로고
    • Effect of the αGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model
    • Daly K.A., Stewart-Akers A.M., Hara H., Ezzelarab M., Long C., Cordero K., et al. Effect of the αGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model. Tissue Eng Part A 2009, 15:3877-3888.
    • (2009) Tissue Eng Part A , vol.15 , pp. 3877-3888
    • Daly, K.A.1    Stewart-Akers, A.M.2    Hara, H.3    Ezzelarab, M.4    Long, C.5    Cordero, K.6


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