Characterization and expansion of baboon CD4+CD25+ Treg cells for potential use in a non-human primate xenotransplantation model

Xenotransplantation

Volumn 14, Issue 4, 2007, Pages 298-308

  Porter, Cynthia M ^a,c   Horvath Arcidiacono, Judith A ^a   Singh, Avneesh K ^b   Horvath, Keith A ^b   Bloom, Eda T ^a   Mohiuddin, Muhammad M ^b  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Baboon; Immune tolerance; Regulatory T cells; Transplantation tolerance; Xenotransplantation

Indexed keywords

REGULATORY T LYMPHOCYTE ASSOCIATED TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; BABOON; BLOOD; CD4+ CD25+ T LYMPHOCYTE; CELL PROLIFERATION; CELLULAR IMMUNITY; CYTOKINE RELEASE; FLOW CYTOMETRY; GRAFT REJECTION; HUMAN; HUMAN CELL; LYMPH NODE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SPLEEN; XENOTRANSPLANTATION;

ANIMALS; ANTIGENS, CD4; CELLS, CULTURED; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE CULTURE TEST, MIXED; PAPIO; SWINE; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION, HETEROLOGOUS;

EID: 34547514184     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2007.00416.x     Document Type: Article

References (49)

1. Chapman LE, Bloom ET. Clinical xenotransplantation. JAMA 2001 285 : 2304 2306.
2. Ibrahim Z, Busch J, Awwad M, Wagner R, Wells K, Cooper DKC. Selected physiologic compatibilities and incompatibilities between human and porcine organ systems. Xenotransplantation 2006 13 : 488 499.
3. Cozzi E, Bosio E, Seveso M, Vadori M, Ancona E. Xenotransplantation - current status and future perspectives. Brit Med Bull 2006 75 : 99 114.
4. Dorling A. Clinical xenotransplantation: pigs might fly? Am J Transplant 2002 2 : 695 700.
5. Sachs DH, Sykes M, Robson SC, Cooper DKC. Xenotransplantation. Adv Immunol 2001 79 : 129 223.
6. Brouard S, Gagne K, Blancho G, Soulillou JP. T cell response in xenorecognition and xenografts: a review. Hum Immunol 1999 60 : 455 468.
7. Sebille F, Dorling A, Lechler RI. The cellular rejection of xenografts - recent insights. Xenotransplantation 2003 10 : 4 6.
8. D'apice AJ. Seventh Congress of the International Xenotransplantation Association, Glasgow, 2003: 'in vivo' highlights. Xenotransplantation 2004 11 : 228 229.
9. Lai L, Kolber-Simonds D, Park KW et al. Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 2002 295 : 1089 1092.
10. Lambrigts D, Sachs DH, Cooper DK. Discordant organ xenotransplantation in primates: world experience and current status. Transplantation 1998 66 : 547 561.
11. Ogata K, Platt JL. Cardiac xenotransplantation: future and limitations. Cardiology 2004 101 : 144 155.
12. Phelps CJ, Koike C, Vaught TD et al. Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 2003 299 : 411 414.
13. D'apice AJ, Nottle MB, Cowan PJ. Genetic modification for xenotransplantation: transgenics and clones. Transplant Proc 2001 33 : 3053 3054.
14. Pham MX, Hunt SA, Johnson FL. Cardiac xenotransplantation. Coron Artery Dis 2004 15 : 99 105.
15. Cooper DKC, Gollackner B, Knosalla C, Teranishi K. Xenotransplantation - how far have we come? Transpl Immunol 2002 9 : 251 256.
16. Samstein B, Platt JL. Xenotransplantation and tolerance. Philos Trans R Soc Lond B Biol Sci 2001 356 : 749 758.
17. Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004 22 : 531 562.
18. Baecher-Allan C, Brown JA, Freeman GJ, Hafter DA. CD4+CD25high regulatory cells in human peripheral blood. J Immunol 2001 167 : 1245 1253.
19. Earle KE, Tang Q, Zhou X et al. In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation. Clin Immunol 2005 115 : 3 9.
20. Baecher-Allan C, Wolf E, Hafler DA. Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells. Clin Immunol 2005 115 : 10 18.
21. Thornton AM, Shevach EM. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998 188 : 287 296.
22. Shevach EM, Dipaolo RA, Andersson J, Zhao DM, Stephens GL, Thornton AM. The lifestyle of naturally occurring CD4+CD25+Foxp3+ regulatory T cells. Immunol Rev 2006 212 : 60 73.
23. Godfrey WR, Ge YG, Spoden DJ et al. In vitro- expanded human CD4+CD25+ T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood 2004 104 : 453 461.
24. Hoffmann P, Eder R, Kunz-Schughart LA, Andreesen R, Edinger M. Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells. Blood 2004 104 : 895 903.
25. Trenado T, Sudres M, Tang Q et al. Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells. J Immunol 2006 176 : 1266 1273.
26. Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003 3 : 199 210.
27. Porter CM, Bloom ET. Human CD4+ CD25+ regulatory T cells suppress anti-porcine xenogeneic responses. Am J Transplant 2005 5 : 2052 2057.
28. Ziegler SF. Foxp3: of mice and men. Annu Rev Immunol 2006 24 : 209 226.
29. Liu W, Putnam AL, Xu-yu Z et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006 203 : 1701 1711.
30. Hartigan-O'Connor DJ, Poon C, Sinclair E, Mccune JM. Human CD4(+) regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods 2007 319 : 41 52.
31. Seddiki N, Santner-Nanan B, Martinson J et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006 203 : 1693 1700.
32. Seddiki N, Santner-Nanan B, Tangye SG et al. Persistence of naive CD45RA+ regulatory T cells in adult life. Blood 2006 107 : 2830 2838.
33. Koenen HJPM, Joosten I. Antigen-specific regulatory T-cell subsets in transplantation tolerance. Regulatory T-cell subset quality reduces the need for quantity. Hum Immunol 2006 67 : 665 675.
34. Jiang S, Tsang J, Game DS, Stevenson S, Lombardi G, Lechler RI. Generation and expression of human CD4+CD25+ regulatory T cells with indirect allospecificity: potential reagents to promote donor-specific transplantation tolerance. Transplantation 2006 82 : 1738 1743.
35. Strauss L, Whiteside TL, Knights A, Bergmann C, Knuth A, Zippelius A. Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin. J Immunol 2007 178 : 320 329.
36. Battaglia M, Stabilini A, Migliavacca B, Horejs-hoeck J, Kaupper T, Roncarolo MG. Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients. J Immunol 2006 177 : 8338 8347.
37. Coenen JJA, Koenen HJPM, Van Rijssen E, Hilbrands LB, Joosten I. Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells. Blood 2006 107 : 1018 1023.
38. Battaglia M, Stabilini A, Roncarolo MG. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 2005 105 : 4743 4748.
39. Zeiser R, Nguyen VH, Beilhack A et al. Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood 2006 108 : 390 399.
40. Meloni F, Morosini M, Solari N et al. Peripheral CD4+CD25+ Treg cell expansion in lung transplant recipients is not affected by calcineurin inhibitors. Int Immunopharmacol 2006 6 : 2002 2010.
41. Zhong R. Gal knockout and beyond. Am J Transplant 2007 7 : 6 11.
42. Takeuchi Y, Magre S, Patience C. The potential hazards of xenotransplantation: an overview. Rev Sci Tech OIE 2005 24 : 323 334.
43. Chen G, Sun H, Yang H et al. The role of anti-non-Gal antibodies in the development of acute humoral xenograft rejection of hDAF transgenic porcine kidneys in baboons receiving anti-Gal antibody neutralization therapy. Transplantation 2006 81 : 273 283.
44. Lim HW, Hillsamer P, Banham AH, Kim CH. Direct suppression of B cells by CD4+CD25+ regulatory T cells. J Immunol 2005 175 : 4180 4183.
45. Zhao DM, Thornton AM, Dipaolo RJ, Shevach EM. Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood 2006 107 : 3925 3932.
46. Janssens W, Carlier V, WU B, Vanderelst L, Gacquemin MG, Saint-Remy JMR. CD4+CD25+ T cells lyse antigen-presenting B cells by Fas-Fas ligand interactions in an epitope-specific manner. J Immunol 2003 171 : 4604 4612.
47. Ghiringhelli F, Ménard C, Terme M et al. CD4+CD25+ regulatory T cells inhibit natural killer cell functions in transforming growth factor-β-dependent manner. J Exp Med 2005 202 : 1075 1085.
48. Cowan PJ. Coagulation and the xenograft endothelium. Xenotransplantation 2007 14 : 7 12.
49. Golshayan D, Jiang S, Tsang J, Garin MI, Mottet C, Lechler RI. In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance. Blood 2007 109 : 827 835.