Characterization of Transgenic Pigs That Express Human Decay Accelerating Factor and Cell Membrane-tethered Human Tissue Factor Pathway Inhibitor

Reproduction in Domestic Animals

Volumn 46, Issue 2, 2011, Pages 325-332

  Lee, H J ^a   Lee, B C ^b   Kim, Y H ^c   Paik, N W ^a   Rho, H M ^a  

^a Inje University   (South Korea)

^b Seoul National University   (South Korea)

^c Digital Bio Technology Co   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

DECAY ACCELERATING FACTOR; LIPOPROTEIN; LIPOPROTEIN-ASSOCIATED COAGULATION INHIBITOR; TISSUE FACTOR PATHWAY INHIBITOR;

ANIMAL; ARTICLE; CELL CULTURE; CELL MEMBRANE; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; HEART MUSCLE; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER; METABOLISM; MOLECULAR BIOLOGY; PHYSIOLOGY; SWINE; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, CD55; CELL MEMBRANE; CELLS, CULTURED; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; LIPOPROTEINS; LIVER; MOLECULAR BIOLOGY; MYOCARDIUM; SWINE;

SUIDAE; SUS;

EID: 79952594087     PISSN: 09366768     EISSN: 14390531     Source Type: Journal    
DOI: 10.1111/j.1439-0531.2010.01670.x     Document Type: Article

References (37)

1. d'Apice AJF, Cowan PJ, 2008: Gene-modified pigs. Xenotransplantation 15, 87-90.
2. Bottino R, Cooper DKC, 2008: Islet xenotransplantation: the pig-to-non-human primate model. Xenotransplantation 15, 104-106.
3. Chen D, Riesbeck K, McVey JH, Kemball-Cook G, Tuddenham EGD, Lechler RI, Dorling A, 2001: Human thrombin and FXa mediate porcine endothelial cell activation; modulation by expression of TFPI-CD4 and hirudin-CD4 fusion proteins. Xenotransplantation 8, 258-265.
4. Chen D, Weber M, McVey JH, Kemball-Cook G, Tuddenham EG, Lechler RI, Dorling A, 2004: Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium. Am J Tansplant 4, 1958-1963.
5. Chen G, Qian H, Starzl T, Sun H, Garcia B, Wang X, Wise Y, Liu Y, Xian Y, Copeman L, Liu W, Jevnikar A, Wall W, Cooper DK, Murase N, Dai Y, Wang W, Xiong Y, White DJ, Zhong R, 2005: Acute rejection is associated with antibodies to nonGal antigens in baboons using Gal-knockout pig kidneys. Nature Med 11, 1295-1298.
6. Chen G, Sun H, Yang H, Kubelik D, Garcia B, Luo Y, Qian A, Copeman L, Liu W, Cardella CJ, Wang W, Xiong Y, Wall W, White DJ, Zhong R, 2006: The role of anti-non-Gal antibodies in the development of acute humoral xenograft rejection of hDAF transgenic porcine Kidneys in baboons receiving anti-Gal antibody neutralization therapy. Transplantation 81, 273-283.
7. Chesik D, Wilczak N, Keyser JDE, 2004: Insulin-like growth factor binding protein-4 interacts with centrosomes and microtubules in primary astrocytes. Neuroscience 125, 381-390.
8. Cowan PJ, 2007: Coagulation and xenograft endothelium. Xenotransplantation 14, 7-12.
9. Cowan PJ, d'Apice AJ, 2009: Complement activation and coagulation in xenotransplantation. Immunol Cell Biol 87, 203-208.
10. Cowan PJ, Shinkel TA, Aminian A, Romanella M, Wigley PL, Lonie AJ, Nottle MB, Pearse MJ, d'Apice AJ, 1998: High-level co expression of complement regulators on vascular endothelium in transgenic mice: CD55 and CD59 provide greater protection from human complement-mediated injury than CD59 alone. Xenotransplantation 5, 184-190.
11. Cu C, Wei X, Wang Y, Chen Y, Liu J, Wang H, Sun G, Yi D, 2008: No infection with porcine endogenous retrovirus in recipients of acellular porcine aortic valves: a two-year study. Xenotransplantation 15, 121-128.
12. Daneau I, Ethier JF, Lussier JG, Silversides DW, 1996: Porcine SRY gene locus and genital ridge expression. Biol Reprod 55, 47-53.
13. Ghebremariam YT, Smith SA, Anderson JB, kahn D, Kotwal G, 2005: Intervention strategies and agents mediating the prevention of xenorejection. Ann N Y Acad Sci 1056, 123-143.
14. Hamamoto T, Yamamoto M, Nordfang O, Peterson JGL, Foster DC, Kisiel W, 1993: Inhibitory properties of full-length and truncated recombinant tissue factor pathway inhibitors (TFPI). J Biol Chem 268, 8704-8710.
15. Hwang EM, Kim SK, Sohn JH, Lee JY, Kim Y, Kim YS, Mook-Jung I, 2006: Furin is an endogenous regulator of alpha-secretase associated APP processing. Biochem Biophys Res Commun 349, 654-659.
16. Iborra A, Mayorga M, Llobet N, Martinez P, 2003: Expression of complement regulatory proteins [membrane cofactor protein (CD46), decay accelerating factor (CD55), and protectin (CD59)] in endometrial stressed cells. Cell Immunol 223, 46-51.
17. Kuwaki K, Tseng YL, Dor FJ, Shimizu A, Houser SL, Sanderson TM, Lanco CJ, Prabharasuth DD, Cheng J, Morgan K, Hisashi Y, Mueller N, Yamada K, Greenstein JL, Hawley RJ, Patience C, Awwad M, Fishman JA, Robson SC, Schuurman HJ, Sachs DH, Cooper DK, 2005: Heart transplantation in baboons using alpha1, 3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med 11, 29-31.
18. Lee JH, Lee HJ, Nahm KM, Jeon HY, Hwang WS, Paik NW, Rho HM, 2006: Effects of combined expression of human complement regulatory proteins and H-transferase on the inhibition of complement mediated cytolysis in porcine embryonic fibroblasts. Transplantation Proc 38, 1618-1621.
19. Lee KFE, Salvaris EJ, Roussel J-C, Robson SC, d'APice AJF, Cowan PJ, 2008: Recombinant pig TFPI efficiently regulates human tissue factor pathways. Xenotransplantation 15, 191-197.
20. -ΔΔC(T) Method. Methods 25, 402-408.
21. Lu T, Jackson MW, Singhi AD, Kandel ES, Yang M, Zhang Y, Gudkov AV, Stark GR, 2009: Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NF. Proc Nat Acad Sci (USA) 106, 16339-16344.
22. Lwaleed BA, Bass PS, 2006: Tissue factor pathway inhibitor: structure, biology and involvement in disease. J Pathol 208, 327-339.
23. McCoard SA, Wise TH, Ford JJ, 2003: Germ cell development in Meishan and White composite gilts. Anim Reprod Sci 77, 85-105.
24. McGregor CG, Teotia SS, Byrne GW, 2004: Cardiac xenotransplantation: progress toward the clinic. Transplantation 78, 1569-1575.
25. Menoret S, Plat M, Blancho G, Martinat-Botte F, Bernard P, Karam G, Tesson L, Renaudin K, Guillouet P, Weill B, Chereau C, Houdebine LM, Soulillou JP, Terqui M, Anegon I, 2004: Characterization of human CD55 and CD59 transgenic pigs and kidney xenotransplantation in the pig-to-baboon combination. Transplantation 77, 1468-1471.
26. Morgan BP, Berg CW, Harris CL, 2005: "Homologous restriction" in complement lysis: roles of membrane complement regulators. Xenotransplantation 12, 258-265.
27. Morgenstern JP, Land H, 1990: A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells. Nucleic Acids Res 18, 3587-3590.
28. Nottle MB, Beebe LF, Harrison SJ, McIlfatrick SM, Ashman RJ, O'Connell PJ, Salvaris EJ, Fisicaro N, Pommey S, Cowan PJ, D'Apice AJ, 2007: Production of homozygous alpha-1, 3-galactosyltransferase knockout pigs by breeding and somatic cell nuclear transfer. Xenotransplantation 14, 339-344.
29. Oh JY, Kim MK, Ko JH, Lee HJ, Kim Y, Park C-S, Park CG, Kim SJ, Wee WR, Lee JH, 2009: Acute cell-mediated rejection in orthotopic pig-to-mouse corneal xenotransplantation. Xenotransplantation 16, 74-82.
30. Rlesbeck K, Dorling A, Kemball-Cook G, McVey JH, Jones M, Tuddenham EGD, Lechler RI, 1997: Human tissue factor pathway inhibitor fused to CD4 binds both FXa and TF/FVIIa at the cell surface. Thromb Haemost 78, 1488-1494.
31. Sachs DH, Yamada K, Robson SC, Fishman JA, Shimizu A, Colvin RB, Sykes M, 2007: GalT-KO pigs: is the cup half empty or half full? Transplantation 84, 12-14.
32. Sandrin MS, Loveland BE, McKenzie IF, 2001: Genetic engineering for xenotransplantation. J Card Surg 16, 448-457.
33. Seya T, Mikata S, Fukui A, Murakam Y, Matsumoto M, Nagasawa S, 1999: Molecular remodeling of complement regulatory proteins for xenotransplantation. Immunopharmacology 42, 75-80.
34. Tomii R, Kurome M, Wako N, Ochial T, Matsunari H, Kano K, Nagashima H, 2009: Production of cloned pigs by nuclear transfer of preadipocytes following cell cycle synchronization by differentiation induction. J Reprod Dev 55, 121-127.
35. Yamada K, Yazawa K, Shimizu A, Iwnaga T, Hisashi Y, Nuhn M, O'Malley P, Nobori S, Vagefi PA, Patience C, Fishman J, Cooper DK, Hawley RJ, Greenstein J, Shuurman HJ, Awward M, Sykes M, Sachs DH, 2005: Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1, 3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nature Med 11, 32-34.
36. Yu J, Dong S, Rushmere NK, Morgan BP, Abagyan R, Tomlinson S, 1997: Mapping the regions of the complement inhibitor CD59 responsible for its species selective activity. Biochemistry 36, 9423-9428.
37. Zhou CY, McInnes E, Copeman L, Langford G, Parsons N, Lancaster R, Richards A, Carrington C, Thompson S, 2005: Transgenic pigs expressing human CD59, in combination with human membrane cofactor protein and human decay accelerating factor. Xenotransplantation 12, 142-148.