Xenogeneic human NK cytotoxicity against porcine endothelial cells is perforin/granzyme B dependent and not inhibited by Bcl-2 overexpression

Xenotransplantation

Volumn 9, Issue 5, 2002, Pages 325-337

  Matter Reissmann, Ulrike B ^a   Forte, Pietro ^a   Schneider, Mårten K J ^a   Filgueira, Luis ^b   Groscurth, Peter ^b   Seebach, Jörg D ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Apoptosis; Bcl 2; Caspase; Cytotoxicity; Human NK cells; Necrosis; Porcine endothelial cells; Xenotransplantation

Indexed keywords

AMMONIUM CHLORIDE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CONCANAMYCIN A; FAS LIGAND; GRANZYME B; PERFORIN; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA;

ALLOTRANSPLANTATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENDOTHELIUM CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; XENOTRANSPLANTATION;

AMINO ACID CHLOROMETHYL KETONES; AMMONIUM CHLORIDE; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIGENS, HETEROPHILE; APOPTOSIS; CALCIUM; CELLS, CULTURED; COCULTURE TECHNIQUES; CYSTEINE ENDOPEPTIDASES; CYTOTOXICITY, IMMUNOLOGIC; DACTINOMYCIN; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; EXOCYTOSIS; FAS LIGAND PROTEIN; GENES, BCL-2; GRAFT REJECTION; GRANZYMES; HUMANS; KILLER CELLS, NATURAL; MACROLIDES; MEMBRANE GLYCOPROTEINS; MICROSCOPY, ELECTRON; NECROSIS; PORE FORMING CYTOTOXIC PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; STAUROSPORINE; SWINE; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN;

EID: 0036766494     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3089.2002.01074.x     Document Type: Article

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