Histopathology of xenografts in pig to non-human primate discordant xenotransplantation

Clinical Transplantation

Volumn 24, Issue SUPPL. 22, 2010, Pages 11-15

  Shimizu, Akira ^a,b   Yamada, Kazuhiko ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

1,3 galactosyltransferase; Acute cellular xenograft rejection; Acute humoral xenogarft rejection; Chronic xenograft rejection; Hyperacute rejection; Pig; Xenotransplantation

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; ANTIBODY; GALACTOSYLGALACTOSE; DISACCHARIDE; GALACTOSYL-(1-3)GALACTOSE;

ACUTE GRAFT REJECTION; BABOON; HISTOPATHOLOGY; HYPERACUTE GRAFT REJECTION; MINIPIG; NONHUMAN; ORGAN DONOR; PRIORITY JOURNAL; REVIEW; VASCULAR ENDOTHELIUM; XENOTRANSPLANTATION; ANIMAL; GENE INACTIVATION; GENETICS; GRAFT REJECTION; HUMAN; IMMUNOLOGICAL TOLERANCE; KIDNEY TRANSPLANTATION; METABOLISM; ORGAN TRANSPLANTATION; PATHOLOGY; SWINE; TRANSGENIC ANIMAL; XENOGRAFT;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISACCHARIDES; ENDOTHELIUM, VASCULAR; GENE KNOCKOUT TECHNIQUES; GRAFT REJECTION; HUMANS; IMMUNE TOLERANCE; KIDNEY TRANSPLANTATION; ORGAN TRANSPLANTATION; PAPIO; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 77954485094     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2010.01270.x     Document Type: Review

References (41)

1. Yamada K, Yazawa K, Shimizu A. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med 2005, 11:32.
2. Griesemer AD, Hirakata A, Shimizu A. Results of gal-knockout porcine thymokidney xenografts. Am J Transplant 2009, 9:2669.
3. Sachs DH. The pig as a potential xenograft donor. Vet Immunol Immunopathol 1994, 43:185.
4. Cooper DK, Gollackner B, Sachs DH. Will the pig solve the transplantation backlog? Annu Rev Med 2002, 53:133.
5. Sachs DH, Sykes M, Robson SC, Cooper DK. Xenotransplantation. Adv Immunol 2001, 79:129.
6. Cascalho M, Ogle BM, Platt JL. Xenotransplantation and the future of renal replacement. J Am Soc Nephrol 2004, 15:1106.
7. Platt JL, Lin SS. The future promises of xenotransplantation. Ann NY Acad Sci 1998, 862:5.
8. Sandrin MS, McKenzie IF. Recent advances in xenotransplantation. Curr Opin Immunol 1999, 11:527.
9. Logan JS. Prospects for xenotransplantation. Curr Opin Immunol 2000, 12:563.
10. Samstein B, Platt JL. Physiologic and immunologic hurdles to xenotransplantation. J Am Soc Nephrol 2001, 12:182.
11. McGregor CG, Teotia SS, Byrne GW. Cardiac xenotransplantation: progress toward the clinic. Transplantation 2004, 78:1569.
12. Lambrigts D, Sachs DH, Cooper DK. Discordant organ xenotransplantation in primates: world experience and current status. Transplantation 1998, 66:547.
13. Phelps CJ, Koike C, Vaught TD. Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 2003, 299:411.
14. Kolber-Simonds D, Lai L, Watt SR. Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations. Proc Natl Acad Sci USA 2004, 101:7335.
15. Ramsoondar JJ, Macháty Z, Costa C, Williams BL, Fodor WL, Bondioli KR. Production of alpha 1,3-galactosyltransferase-knockout cloned pigs expressing human alpha 1,2-fucosylosyltransferase. Biol Reprod 2003, 69:437.
16. Takahagi Y, Fujimura T, Miyagawa S. Production of alpha 1,3-galactosyltransferase gene knockout pigs expressing both human decay-accelerating factor and N-acetylglucosaminyltransferase III. Mol Reprod Dev 2005, 71:331.
17. Nottle MB, Beebe LF, Harrison SJ. Production of homozygous alpha-1,3-galactosyltransferase knockout pigs by breeding and somatic cell nuclear transfer. Xenotransplantation 2007, 14:339.
18. Shimizu A, Yamada K. Pathology of renal xenograft rejection in pig to non-human primate transplantation. Clin Transplant 2006, 20(Suppl 15):46.
19. Rose AG, Cooper DK. A histopathologic grading system of hyperacute (humoral, antibody-mediated) cardiac xenograft and allograft rejection. J Heart Lung Transplant 1996, 15:804.
20. Schuurman HJ, Cheng J, Lam T. Pathology of xenograft rejection: a commentary. Xenotransplantation 2003, 10:293.
21. Bach FH, Robson SC, Ferran C. Endothelial cell activation and thromboregulation during xenograft rejection. Immunol Rev 1994, 141:5.
22. Robson SC, Schulte am Esch J, Bach FH. Factors in xenograft rejection. Ann NY Acad Sci 1999, 875:261.
23. Shimizu A, Yamada K, Yamamoto S. Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts. J Am Soc Nephrol 2005, 16:2732.
24. Palmetshofer A, Galili U, Dalmasso AP, Robson SC, Bach FH. Alpha-galactosyl epitope-mediated activation of porcine aortic endothelial cells: type II activation. Transplantation 1998, 65:971.
25. O'Connell PJ. Thrombotic microangiopathy: the next big hurdle for xenotransplantation. J Am Soc Nephrol 2005, 16:2592.
26. Shimizu A, Meehan SM, Kozlowski T. Acute humoral xenograft rejection: destruction of the microvascular capillary endothelium in pig-to-nonhuman primate renal grafts. Lab Invest 2000, 80:815.
27. Shimizu A, Colvin RB. Determining the histologic and Immunopathologic features of acute humoral xenograft rejection. Graft 2001, 4:44.
28. Shimizu A, Hisashi Y, Kuwaki K. Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons. Am J Pathol 2008, 172:1471.
29. Buhler L, Xu Y, Li W, Zhu A, Cooper DK. An investigation of the specificity of induced anti-pig antibodies in baboons. Xenotransplantation 2003, 10:88.
30. Chen G, Qian H, Starzl T. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med 2005, 11:1295.
31. Yamada K, Sachs DH, DerSimonian H. Direct and indirect recognition of pig class II antigens by human T cells. Transplant Proc 1995, 27:258.
32. Yamada K, Seebach J, DerSimonian H, Sachs DH. Human anti-pig T- cell mediated cytotoxity. Xenotransplantation 1996, 3:179.
33. Houser SL, Kuwaki K, Knosalla C. Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons. Xenotransplantation 2004, 11:416.
34. Hisashi Y, Yamada K, Kuwaki K. Rejection of cardiac xenografts transplanted from alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs to baboons. Am J Transplant 2008, 8:2516.
35. Chapman JR, O'Connell PJ, Nankivell BJ. Chronic renal allograft dysfunction. J Am Soc Nephrol 2005, 16:3015.
36. Solez K, Colvin RB, Racusen LC. Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant 2007, 7:518.
37. Zhao Y, Swenson K, Sergio JJ, Arn JS, Sachs DH, Sykes M. Skin graft tolerance across a discordant xenogeneic barrier. Nat Med 1996, 2:1211.
38. Habiro K, Sykes M, Yang YG. Induction of human T-cell tolerance to pig xenoantigens via thymus transplantation in mice with an established human immune system. Am J Transplant 2009, 9:1324.
39. Lechler RI, Sykes M, Thomson AW, Turka LA. Organ transplantation: how much of the promise has been realized? Nat Med 2005, 11:605.
40. Yamada K, Griesemer A, Sykes M, Sachs DH. Cotransplantation vascularized thymus and kidney from GalT-KO pigs to baboons. Xenotransplantation 2007, 14:186.
41. Sachs DH, Sykes M, Yamada K. Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy. Transpl Immunol 2009, 21:101. Epub 2008 Dec 6. Review