Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys

Xenotransplantation

Volumn 18, Issue 6, 2011, Pages 355-368

  Petersen, Björn ^a   Ramackers, Wolf ^b   Lucas Hahn, Andrea ^a   Lemme, Erika ^a   Hassel, Petra ^a   Queißer, Anna Lisa ^a   Herrmann, Doris ^a   Barg Kues, Brigitte ^a   Carnwath, Joseph W ^a   Klose, Johannes ^b   Tiede, Andreas ^c   Friedrich, Lars ^d   Baars, Wiebke ^b   Schwinzer, Reinhard ^b   Winkler, Michael ^b   Niemann, Heiner ^a  

^a FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^b Transplant Laboratory   (Germany)

^c Department of Haematology Haemostasis and Oncology ^*  (Germany)

^d HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

anti apoptotic; ex vivo kidney perfusion; human heme oxygenase 1; transgenic pigs; xenotransplantation

Indexed keywords

D DIMER; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FIBRINOGEN; GAMMA INTERFERON; HEME OXYGENASE 1; HEME OXYGENASE INHIBITOR; INTERCELLULAR ADHESION MOLECULE 1; TRANSACTIVATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; ZINC PROTOPORPHORINE 9;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL CULTURE; CONTROLLED STUDY; EMBRYO; EPITHELIUM CELL; EX VIVO STUDY; FIBROBLAST; GENE EXPRESSION; KIDNEY BLOOD FLOW; KIDNEY GRAFT REJECTION; KIDNEY PERFUSION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; RENAL PROTECTION; SWINE; UPREGULATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELLS, CULTURED; ENDOTHELIAL CELLS; GRAFT REJECTION; HEME OXYGENASE-1; HUMANS; KIDNEY; PERFUSION; SWINE; TRANSGENES; TRANSPLANTATION, HETEROLOGOUS;

EID: 83755225193     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2011.00674.x     Document Type: Article

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