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Volumn 84, Issue 2, 2007, Pages 244-250

Characterization of natural human anti-non-Gal antibodies and their effect on activation of porcine Gal-deficient endothelial cells

Author keywords

Acute vascular rejection; Complement system; Immunoglobulin; Porcine endothelial cell; Xenotransplantation

Indexed keywords

ANTIBODY; ANTIGEN; COMPLEMENT INHIBITOR; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; EPITOPE; GAL ANTIBODY; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN M; UNCLASSIFIED DRUG;

EID: 34547643527     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000268815.90675.d5     Document Type: Article
Times cited : (46)

References (43)
  • 1
    • 0027716847 scopus 로고
    • Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation
    • Oriol R, Ye Y, Koren E, Cooper DK. Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation. Transplantation 1993; 56: 1433.
    • (1993) Transplantation , vol.56 , pp. 1433
    • Oriol, R.1    Ye, Y.2    Koren, E.3    Cooper, D.K.4
  • 2
    • 0027295654 scopus 로고
    • Evolution and pathophysiology of the human natural anti-alpha-galactosyl IgG (anti-Gal) antibody
    • Galili U. Evolution and pathophysiology of the human natural anti-alpha-galactosyl IgG (anti-Gal) antibody. Springer Semin Immunopathol 1993; 15: 155.
    • (1993) Springer Semin Immunopathol , vol.15 , pp. 155
    • Galili, U.1
  • 3
    • 0034851054 scopus 로고    scopus 로고
    • The alpha-gal epitope (Gal alpha 1-3Gal beta 1-4GlcNAc-R) in xenotransplantation
    • Galili U. The alpha-gal epitope (Gal alpha 1-3Gal beta 1-4GlcNAc-R) in xenotransplantation. Biochimie 2001; 83: 557.
    • (2001) Biochimie , vol.83 , pp. 557
    • Galili, U.1
  • 4
    • 0026654128 scopus 로고
    • Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients
    • Dalmasso AP, Vercellotti GM, Fischel RJ, et al. Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients. Am J Pathol 1992; 140: 1157.
    • (1992) Am J Pathol , vol.140 , pp. 1157
    • Dalmasso, A.P.1    Vercellotti, G.M.2    Fischel, R.J.3
  • 5
    • 0032570299 scopus 로고    scopus 로고
    • Removal of anti-porcine natural antibodies from human and nonhuman primate plasma in vitro and in vivo by a Galalpha1-3Galbeta1-4betaGlc-X immunoaffinity column
    • Xu Y, Lorf T, Sablinski T, et al. Removal of anti-porcine natural antibodies from human and nonhuman primate plasma in vitro and in vivo by a Galalpha1-3Galbeta1-4betaGlc-X immunoaffinity column. Transplantation 1998; 65: 172.
    • (1998) Transplantation , vol.65 , pp. 172
    • Xu, Y.1    Lorf, T.2    Sablinski, T.3
  • 6
    • 0030888345 scopus 로고    scopus 로고
    • In vivo and in vitro optimization of depletion of IgM and IgG xenoantibodies by immunoadsorption using cell membrane proteins
    • Lucchiari N, Azimzadeh A, Wolf P, et al. In vivo and in vitro optimization of depletion of IgM and IgG xenoantibodies by immunoadsorption using cell membrane proteins. Artif Organs 1997; 21: 278.
    • (1997) Artif Organs , vol.21 , pp. 278
    • Lucchiari, N.1    Azimzadeh, A.2    Wolf, P.3
  • 7
    • 0029033071 scopus 로고
    • Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury
    • McCurry KR, Kooyman DL, Alvarado CG, et al. Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nat Med 1995; 1: 423.
    • (1995) Nat Med , vol.1 , pp. 423
    • McCurry, K.R.1    Kooyman, D.L.2    Alvarado, C.G.3
  • 8
    • 0029068597 scopus 로고
    • The generation of transgenic pigs as potential organ donors for humans
    • Cozzi E, White DJ. The generation of transgenic pigs as potential organ donors for humans. Nat Med 1995; 1: 964.
    • (1995) Nat Med , vol.1 , pp. 964
    • Cozzi, E.1    White, D.J.2
  • 9
    • 0347367029 scopus 로고    scopus 로고
    • Production of alpha 1,3-galactosyltransferase-deficient pigs
    • Phelps CJ, Koike C, Vaught TD, et al. Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 2003; 299: 411.
    • (2003) Science , vol.299 , pp. 411
    • Phelps, C.J.1    Koike, C.2    Vaught, T.D.3
  • 10
    • 0037039771 scopus 로고    scopus 로고
    • Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning
    • Lai L, Kolber-Simonds D, Park KW, et al. Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 2002; 295: 1089.
    • (2002) Science , vol.295 , pp. 1089
    • Lai, L.1    Kolber-Simonds, D.2    Park, K.W.3
  • 11
    • 10744228498 scopus 로고    scopus 로고
    • Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human antihuman CD154 mAb-based regimen
    • Kuwaki K, Knosalla C, Dor FJ, et al. Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human antihuman CD154 mAb-based regimen. Am J Transplant 2004; 4: 363.
    • (2004) Am J Transplant , vol.4 , pp. 363
    • Kuwaki, K.1    Knosalla, C.2    Dor, F.J.3
  • 12
    • 33644862221 scopus 로고    scopus 로고
    • The role of anti-non-Gal antibodies in the development of acute humoral xenograft rejection of hDAF transgenic porcine kidneys in baboons receiving anti-Gal antibody neutralization therapy
    • Chen G, Sun H, Yang H, et al. The role of anti-non-Gal antibodies in the development of acute humoral xenograft rejection of hDAF transgenic porcine kidneys in baboons receiving anti-Gal antibody neutralization therapy. Transplantation 2006; 81: 273.
    • (2006) Transplantation , vol.81 , pp. 273
    • Chen, G.1    Sun, H.2    Yang, H.3
  • 13
    • 28644446730 scopus 로고    scopus 로고
    • Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys
    • Chen G, Qian H, Starzl T, et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med 2005; 11: 1295.
    • (2005) Nat Med , vol.11 , pp. 1295
    • Chen, G.1    Qian, H.2    Starzl, T.3
  • 15
    • 0017665490 scopus 로고
    • Antigen of "serum sickness" type of heterophile antibodies in human sera: Indentification as gangliosides with N-glycolylneuraminic acid
    • Higashi H, Naiki M, Matuo S, Okouchi K. Antigen of "serum sickness" type of heterophile antibodies in human sera: indentification as gangliosides with N-glycolylneuraminic acid. Biochem Biophys Res Commun 1977; 79: 388.
    • (1977) Biochem Biophys Res Commun , vol.79 , pp. 388
    • Higashi, H.1    Naiki, M.2    Matuo, S.3    Okouchi, K.4
  • 16
    • 0018152253 scopus 로고
    • Characterization of the Hanganutziu-Deicher (serum-sickness) antigen as gangliosides containing n-glycolylneuraminic acid
    • Merrick JM, Zadarlik K, Milgrom F. Characterization of the Hanganutziu-Deicher (serum-sickness) antigen as gangliosides containing n-glycolylneuraminic acid. Int Arch Allergy Appl Immunol 1978; 57: 477.
    • (1978) Int Arch Allergy Appl Immunol , vol.57 , pp. 477
    • Merrick, J.M.1    Zadarlik, K.2    Milgrom, F.3
  • 17
    • 0029730751 scopus 로고    scopus 로고
    • Simultaneous expression by porcine aorta endothelial cells of glycosphingolipids bearing the major epitope for human xenoreactive antibodies (Gal alpha 1-3Gal), blood group H determinant and N-glycolylneuraminic acid
    • Bouhours D, Pourcel C, Bouhours JE. Simultaneous expression by porcine aorta endothelial cells of glycosphingolipids bearing the major epitope for human xenoreactive antibodies (Gal alpha 1-3Gal), blood group H determinant and N-glycolylneuraminic acid. Glycoconj J 1996; 13: 947.
    • (1996) Glycoconj J , vol.13 , pp. 947
    • Bouhours, D.1    Pourcel, C.2    Bouhours, J.E.3
  • 18
    • 0033062487 scopus 로고    scopus 로고
    • Significance of histochemical expression of Hanganutziu-Deicher antigens in pig, baboon and human tissues
    • Morozumi K, Kobayashi T, Usami T, et al. Significance of histochemical expression of Hanganutziu-Deicher antigens in pig, baboon and human tissues. Transplant Proc 1999; 31: 942.
    • (1999) Transplant Proc , vol.31 , pp. 942
    • Morozumi, K.1    Kobayashi, T.2    Usami, T.3
  • 19
    • 0029803151 scopus 로고    scopus 로고
    • Gangliosides expressed in human breast cancer
    • Marquina G, Waki H, Fernandez LE, et al. Gangliosides expressed in human breast cancer. Cancer Res 1996; 56: 5165.
    • (1996) Cancer Res , vol.56 , pp. 5165
    • Marquina, G.1    Waki, H.2    Fernandez, L.E.3
  • 20
    • 0022481893 scopus 로고
    • Detection of 4-O-acetyl-N-glycolylneuraminyl lactosylceramide as one of tumor-associated antigens in human colon cancer tissues by specific antibody
    • Miyoshi I, Higashi H, Hirabayashi Y, et al. Detection of 4-O-acetyl-N-glycolylneuraminyl lactosylceramide as one of tumor-associated antigens in human colon cancer tissues by specific antibody. Mol Immunol 1986; 23: 631.
    • (1986) Mol Immunol , vol.23 , pp. 631
    • Miyoshi, I.1    Higashi, H.2    Hirabayashi, Y.3
  • 21
    • 0020409782 scopus 로고
    • Hanganutziu-Deicher antibodies in infectious mononucleosis and other diseases
    • Morito T, Kano K, Milgrom F. Hanganutziu-Deicher antibodies in infectious mononucleosis and other diseases. J Immunol 1982; 129: 2524.
    • (1982) J Immunol , vol.129 , pp. 2524
    • Morito, T.1    Kano, K.2    Milgrom, F.3
  • 22
    • 0142059844 scopus 로고    scopus 로고
    • Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid
    • Tangvoranuntakul P, Gagneux P, Diaz S, et al. Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid. Proc Natl Acad Sci U S A 2003; 100: 12045.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12045
    • Tangvoranuntakul, P.1    Gagneux, P.2    Diaz, S.3
  • 23
    • 2442538314 scopus 로고    scopus 로고
    • Are N-glycolylneuraminic acid (Hanganutziu-Deicher) antigens important in pig-to-human xenotransplantation?
    • Miwa Y, Kobayashi T, Nagasaka T, et al. Are N-glycolylneuraminic acid (Hanganutziu-Deicher) antigens important in pig-to-human xenotransplantation? Xenotransplantation 2004; 11: 247.
    • (2004) Xenotransplantation , vol.11 , pp. 247
    • Miwa, Y.1    Kobayashi, T.2    Nagasaka, T.3
  • 24
    • 0036872920 scopus 로고    scopus 로고
    • Anti-N-glycolylneuraminic acid antibodies identified in healthy human serum
    • Zhu A, Hurst R. Anti-N-glycolylneuraminic acid antibodies identified in healthy human serum. Xenotransplantation 2002; 9: 376.
    • (2002) Xenotransplantation , vol.9 , pp. 376
    • Zhu, A.1    Hurst, R.2
  • 25
    • 0033802119 scopus 로고    scopus 로고
    • Lack of antibody production against Hanganutziu-Deicher (H-D) antigens with N-glycolylneuraminic acid in patients with porcine exposure history
    • Kobayashi T, Yokoyama I, Suzuki A, et al. Lack of antibody production against Hanganutziu-Deicher (H-D) antigens with N-glycolylneuraminic acid in patients with porcine exposure history. Xenotransplantation 2000; 7: 177.
    • (2000) Xenotransplantation , vol.7 , pp. 177
    • Kobayashi, T.1    Yokoyama, I.2    Suzuki, A.3
  • 26
    • 0036766238 scopus 로고    scopus 로고
    • Human serum-induced porcine endothelial cell E-selectin expression is associated with IgG3 and IgM anti-Gal antibodies
    • Saethre M, Solvik UO, Haraldsen G, et al. Human serum-induced porcine endothelial cell E-selectin expression is associated with IgG3 and IgM anti-Gal antibodies. Xenotransplantation 2002; 9: 350.
    • (2002) Xenotransplantation , vol.9 , pp. 350
    • Saethre, M.1    Solvik, U.O.2    Haraldsen, G.3
  • 27
    • 33744773774 scopus 로고    scopus 로고
    • Human complement-activating immunoglobulin (Ig)G3 antibodies are essential for porcine endothelial cell activation
    • Saethre M, Lea T, Borgen MS, et al. Human complement-activating immunoglobulin (Ig)G3 antibodies are essential for porcine endothelial cell activation. Xenotransplantation 2006; 13: 215.
    • (2006) Xenotransplantation , vol.13 , pp. 215
    • Saethre, M.1    Lea, T.2    Borgen, M.S.3
  • 28
    • 33846590924 scopus 로고    scopus 로고
    • Reactivity of human natural antibodies to endothelial cells from Galα(1,3)-deficient pigs
    • Baumann BC, Stussi G, Huggel K, et al. Reactivity of human natural antibodies to endothelial cells from Galα(1,3)-deficient pigs. Transplantation 2007; 83: 193.
    • (2007) Transplantation , vol.83 , pp. 193
    • Baumann, B.C.1    Stussi, G.2    Huggel, K.3
  • 29
    • 27244444553 scopus 로고    scopus 로고
    • Isotype-specific detection of ABO blood group antibodies using a novel flow cytometric method
    • Stussi G, Huggel K, Lutz HU, et al. Isotype-specific detection of ABO blood group antibodies using a novel flow cytometric method. Br J Haematol 2005; 130: 954.
    • (2005) Br J Haematol , vol.130 , pp. 954
    • Stussi, G.1    Huggel, K.2    Lutz, H.U.3
  • 31
    • 2442458742 scopus 로고    scopus 로고
    • Lack of galactose-alpha-1, 3-galactose expression on porcine endothelial cells prevents complement-induced lysis but not direct xenogeneic NK cytotoxicity
    • Baumann BC, Forte P, Hawley RJ, et al. Lack of galactose-alpha-1, 3-galactose expression on porcine endothelial cells prevents complement-induced lysis but not direct xenogeneic NK cytotoxicity. J Immunol 2004; 172: 6460.
    • (2004) J Immunol , vol.172 , pp. 6460
    • Baumann, B.C.1    Forte, P.2    Hawley, R.J.3
  • 32
    • 0041665163 scopus 로고    scopus 로고
    • Pre-neutralization of C5a-mediated effects by the monoclonal antibody 137-26 reacting with the C5a moiety of native C5 without preventing C5 cleavage
    • Fung M, Lu M, Fure H, et al. Pre-neutralization of C5a-mediated effects by the monoclonal antibody 137-26 reacting with the C5a moiety of native C5 without preventing C5 cleavage. Clin Exp Immunol 2003; 133: 160.
    • (2003) Clin Exp Immunol , vol.133 , pp. 160
    • Fung, M.1    Lu, M.2    Fure, H.3
  • 33
    • 13444282227 scopus 로고    scopus 로고
    • Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience
    • Kuwaki K, Tseng YL, Dor FJ, et al. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med 2005; 11: 29.
    • (2005) Nat Med , vol.11 , pp. 29
    • Kuwaki, K.1    Tseng, Y.L.2    Dor, F.J.3
  • 34
    • 13444269248 scopus 로고    scopus 로고
    • Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3- galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
    • Yamada K, Yazawa K, Shimizu A, et al. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3- galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med 2005; 11: 32.
    • (2005) Nat Med , vol.11 , pp. 32
    • Yamada, K.1    Yazawa, K.2    Shimizu, A.3
  • 35
    • 2942661758 scopus 로고    scopus 로고
    • Acute vascular rejection of xenografts: Roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity
    • Gollackner B, Goh SK, Qawi I, et al. Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity. Transplantation 2004; 77: 1735.
    • (2004) Transplantation , vol.77 , pp. 1735
    • Gollackner, B.1    Goh, S.K.2    Qawi, I.3
  • 36
    • 7044235964 scopus 로고    scopus 로고
    • Anti-non-Gal porcine endothelial cell antibodies in acute humoral xenograft rejection of hDAF-transgenic porcine hearts in cynomolgus monkeys
    • Lam TT, Paniagua R, Shivaram G, et al. Anti-non-Gal porcine endothelial cell antibodies in acute humoral xenograft rejection of hDAF-transgenic porcine hearts in cynomolgus monkeys. Xenotransplantation 2004; 11: 531.
    • (2004) Xenotransplantation , vol.11 , pp. 531
    • Lam, T.T.1    Paniagua, R.2    Shivaram, G.3
  • 37
    • 33745094078 scopus 로고    scopus 로고
    • Allosensitized humans are at no greater risk of humoral rejection of GT-KO pig organs than other humans
    • Hara H, Ezzelarab M, Rood PP, et al. Allosensitized humans are at no greater risk of humoral rejection of GT-KO pig organs than other humans. Xenotransplantation 2006; 13: 357.
    • (2006) Xenotransplantation , vol.13 , pp. 357
    • Hara, H.1    Ezzelarab, M.2    Rood, P.P.3
  • 38
    • 0032522737 scopus 로고    scopus 로고
    • Alpha-galactosyl epitopemediated activation of porcine aortic endothelial cells: Type II activation
    • Palmetshofer A, Galili U, Dalmasso AP, et al. Alpha-galactosyl epitopemediated activation of porcine aortic endothelial cells: type II activation. Transplantation 1998; 65: 971.
    • (1998) Transplantation , vol.65 , pp. 971
    • Palmetshofer, A.1    Galili, U.2    Dalmasso, A.P.3
  • 39
    • 0035663424 scopus 로고    scopus 로고
    • Human serum-induced expression of E-selectin on porcine aortic endothelial cells in vitro is totally complement mediated
    • Solvik UO, Haraldsen G, Fiane AE, et al. Human serum-induced expression of E-selectin on porcine aortic endothelial cells in vitro is totally complement mediated. Transplantation 2001; 72: 1967.
    • (2001) Transplantation , vol.72 , pp. 1967
    • Solvik, U.O.1    Haraldsen, G.2    Fiane, A.E.3
  • 40
    • 18644372883 scopus 로고    scopus 로고
    • Endothelial cells derived from pigs lacking Gal alpha(1,3)Gal: No reduction of human leukocyte adhesion and natural killer cell cytotoxicity
    • Baumann BC, Schneider MK, Lilienfeld BG, et al. Endothelial cells derived from pigs lacking Gal alpha(1,3)Gal: No reduction of human leukocyte adhesion and natural killer cell cytotoxicity. Transplantation 2005; 79: 1067.
    • (2005) Transplantation , vol.79 , pp. 1067
    • Baumann, B.C.1    Schneider, M.K.2    Lilienfeld, B.G.3
  • 41
    • 29144436254 scopus 로고    scopus 로고
    • alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months
    • Tseng YL, Kuwaki K, Dor FJ, et al. alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months. Transplantation 2005; 80: 1493.
    • (2005) Transplantation , vol.80 , pp. 1493
    • Tseng, Y.L.1    Kuwaki, K.2    Dor, F.J.3
  • 42
    • 32044445822 scopus 로고    scopus 로고
    • The molecular basis for galalpha(1,3)gal expression in animals with a deletion of the alpha1,3galactosyltransferase gene
    • Milland J, Christiansen D, Lazarus BD, et al. The molecular basis for galalpha(1,3)gal expression in animals with a deletion of the alpha1,3galactosyltransferase gene. J Immunol 2006; 176: 2448.
    • (2006) J Immunol , vol.176 , pp. 2448
    • Milland, J.1    Christiansen, D.2    Lazarus, B.D.3
  • 43
    • 0037468446 scopus 로고    scopus 로고
    • Pig cells that lack the gene for alpha1-3 galactosyltransferase express low levels of the gal antigen
    • Sharma A, Naziruddin B, Cui C, et al. Pig cells that lack the gene for alpha1-3 galactosyltransferase express low levels of the gal antigen. Transplantation 2003; 75: 430.
    • (2003) Transplantation , vol.75 , pp. 430
    • Sharma, A.1    Naziruddin, B.2    Cui, C.3


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