메뉴 건너뛰기




Volumn 17, Issue 1, 2010, Pages 26-37

Potential value of human thrombomodulin and DAF expression for coagulation control in pig-to-human xenotransplantation

Author keywords

Coagulation disorder; Decay accelerating factor; Gene transfer; Thrombomodulin; Xenotransplantation

Indexed keywords

ACTIVATED PROTEIN C; BETA GALACTOSIDASE; CD97 ANTIGEN; THROMBIN; THROMBOMODULIN;

EID: 76349087621     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2009.00555.x     Document Type: Article
Times cited : (58)

References (53)
  • 1
    • 13444282227 scopus 로고    scopus 로고
    • Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience
    • Kuwaki K, Tseng Y, Dor F et al. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med 2005 11 : 29 31.
    • (2005) Nat Med , vol.11 , pp. 29-31
    • Kuwaki, K.1    Tseng, Y.2    Dor, F.3
  • 2
    • 44849144688 scopus 로고    scopus 로고
    • Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons
    • Shimizu A, Hisashi Y, Kuwaki K et al. Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons. Am J Pathol 2008 172 : 1471 1481.
    • (2008) Am J Pathol , vol.172 , pp. 1471-1481
    • Shimizu, A.1    Hisashi, Y.2    Kuwaki, K.3
  • 3
    • 0034661964 scopus 로고    scopus 로고
    • Long-term survival of nonhuman primates receiving life-supporting transgenic porcine kidney xenografts
    • Cozzi E, Bhatti F, Schmoeckel M et al. Long-term survival of nonhuman primates receiving life-supporting transgenic porcine kidney xenografts. Transplantation 2000 70 : 15 21.
    • (2000) Transplantation , vol.70 , pp. 15-21
    • Cozzi, E.1    Bhatti, F.2    Schmoeckel, M.3
  • 4
    • 28544445587 scopus 로고    scopus 로고
    • The influence of baseline expression of human decay accelerating factor transgene on graft survival and acute humoral xenograft rejection
    • Sun H, Chen G, Liu W et al. The influence of baseline expression of human decay accelerating factor transgene on graft survival and acute humoral xenograft rejection. Transplantation 2005 80 : 1331 1339.
    • (2005) Transplantation , vol.80 , pp. 1331-1339
    • Sun, H.1    Chen, G.2    Liu, W.3
  • 5
    • 33644810480 scopus 로고    scopus 로고
    • Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts
    • Shimizu A, Yamada K, Yamamoto S et al. Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts. J Am Soc Nephrol 2005 16 : 2732 2745.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2732-2745
    • Shimizu, A.1    Yamada, K.2    Yamamoto, S.3
  • 6
    • 0034721334 scopus 로고    scopus 로고
    • Role and regulation of pig CD59 and membrane cofactor protein/CD46 expressed on pig aortic endothelial cells
    • Van Den Berg C, Rix C, Hanna S et al. Role and regulation of pig CD59 and membrane cofactor protein/CD46 expressed on pig aortic endothelial cells. Transplantation 2000 70 : 667 673.
    • (2000) Transplantation , vol.70 , pp. 667-673
    • Van Den Berg, C.1    Rix, C.2    Hanna, S.3
  • 7
    • 0035156757 scopus 로고    scopus 로고
    • Human membrane cofactor protein (MCP, CD 46) protects transgenic pig hearts from hyperacute rejection in primates
    • Adams D, Kadner A, Chen R, Farivar R. Human membrane cofactor protein (MCP, CD 46) protects transgenic pig hearts from hyperacute rejection in primates. Xenotransplantation 2001 8 : 36 40.
    • (2001) Xenotransplantation , vol.8 , pp. 36-40
    • Adams, D.1    Kadner, A.2    Chen, R.3    Farivar, R.4
  • 8
    • 34547610974 scopus 로고    scopus 로고
    • Islet surface heparinization prevents the instant blood-mediated inflammatory reaction in islet transplantation
    • Cabric S, Sanchez J, Lundgren T et al. Islet surface heparinization prevents the instant blood-mediated inflammatory reaction in islet transplantation. Diabetes 2007 56 : 2008 2015.
    • (2007) Diabetes , vol.56 , pp. 2008-2015
    • Cabric, S.1    Sanchez, J.2    Lundgren, T.3
  • 9
    • 0030897023 scopus 로고    scopus 로고
    • Effect of porcine endothelial tissue factor pathway inhibitor on human coagulation factors
    • Kopp C, Siegel J, Hancock W et al. Effect of porcine endothelial tissue factor pathway inhibitor on human coagulation factors. Transplantation 1997 63 : 749 758.
    • (1997) Transplantation , vol.63 , pp. 749-758
    • Kopp, C.1    Siegel, J.2    Hancock, W.3
  • 10
    • 0033557189 scopus 로고    scopus 로고
    • Inhibition of tissue factor-dependent and -independent coagulation by cell surface expression of novel anticoagulant fusion proteins
    • Chen D, Riesbeck K, Kemball-Cook G et al. Inhibition of tissue factor-dependent and -independent coagulation by cell surface expression of novel anticoagulant fusion proteins. Transplantation 1999 67 : 467 474.
    • (1999) Transplantation , vol.67 , pp. 467-474
    • Chen, D.1    Riesbeck, K.2    Kemball-Cook, G.3
  • 11
    • 47349107350 scopus 로고    scopus 로고
    • Recombinant pig TFPI efficiently regulates human tissue factor pathways
    • Lee K, Salvaris E, Roussel J et al. Recombinant pig TFPI efficiently regulates human tissue factor pathways. Xenotransplantation 2008 15 : 191 197.
    • (2008) Xenotransplantation , vol.15 , pp. 191-197
    • Lee, K.1    Salvaris, E.2    Roussel, J.3
  • 12
    • 0030802799 scopus 로고    scopus 로고
    • Xenogeneic endothelial cells activate human prothrombin
    • Siegel J, Grey S, Lesnikoski B et al. Xenogeneic endothelial cells activate human prothrombin. Transplantation 1997 64 : 888 896.
    • (1997) Transplantation , vol.64 , pp. 888-896
    • Siegel, J.1    Grey, S.2    Lesnikoski, B.3
  • 13
    • 0032558117 scopus 로고    scopus 로고
    • Expression of human thrombomodulin cofactor activity in porcine endothelial cells
    • Kopp C, Grey S, Siegel J et al. Expression of human thrombomodulin cofactor activity in porcine endothelial cells. Transplantation 1998 66 : 244 251.
    • (1998) Transplantation , vol.66 , pp. 244-251
    • Kopp, C.1    Grey, S.2    Siegel, J.3
  • 14
    • 44449173082 scopus 로고    scopus 로고
    • Pig thrombomodulin binds human thrombin but is a poor cofactor for activation of human protein C and TAFI
    • Roussel J, Moran C, Salvaris E et al. Pig thrombomodulin binds human thrombin but is a poor cofactor for activation of human protein C and TAFI. Am J Transplant 2008 8 : 1101 1112.
    • (2008) Am J Transplant , vol.8 , pp. 1101-1112
    • Roussel, J.1    Moran, C.2    Salvaris, E.3
  • 15
    • 0020628416 scopus 로고
    • Inactivation of human coagulation factor v by activated protein C
    • Suzuki K, Stenflo J, Dahlbäck B, Teodorsson B. Inactivation of human coagulation factor V by activated protein C. J Biol Chem 1983 258 : 1914 1920.
    • (1983) J Biol Chem , vol.258 , pp. 1914-1920
    • Suzuki, K.1    Stenflo, J.2    Dahlbäck, B.3    Teodorsson, B.4
  • 16
    • 0021344553 scopus 로고
    • Proteolytic inactivation of human factor VIII procoagulant protein by activated human protein C and its analogy with factor v
    • Fulcher C, Gardiner J, Griffin J, Zimmerman T. Proteolytic inactivation of human factor VIII procoagulant protein by activated human protein C and its analogy with factor V. Blood 1984 63 : 486 489.
    • (1984) Blood , vol.63 , pp. 486-489
    • Fulcher, C.1    Gardiner, J.2    Griffin, J.3    Zimmerman, T.4
  • 17
    • 35948934636 scopus 로고    scopus 로고
    • Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
    • Isermann B, Vinnikov I, Madhusudhan T et al. Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Nat Med 2007 13 : 1349 1358.
    • (2007) Nat Med , vol.13 , pp. 1349-1358
    • Isermann, B.1    Vinnikov, I.2    Madhusudhan, T.3
  • 19
    • 0029891339 scopus 로고    scopus 로고
    • Activation of human prothrombin by porcine aortic endothelial cells - A potential barrier to pig to human xenotransplantation
    • Jurd K, Gibbs R, Hunt B. Activation of human prothrombin by porcine aortic endothelial cells - a potential barrier to pig to human xenotransplantation. Blood Coagul Fibrinolysis 1996 7 : 336 343.
    • (1996) Blood Coagul Fibrinolysis , vol.7 , pp. 336-343
    • Jurd, K.1    Gibbs, R.2    Hunt, B.3
  • 20
    • 0037094135 scopus 로고    scopus 로고
    • Kinetic analysis of a unique direct prothrombinase, fgl2, and identification of a serine residue critical for the prothrombinase activity
    • Chan C, Chan M, Liu M et al. Kinetic analysis of a unique direct prothrombinase, fgl2, and identification of a serine residue critical for the prothrombinase activity. J Immunol 2002 168 : 5170 5177.
    • (2002) J Immunol , vol.168 , pp. 5170-5177
    • Chan, C.1    Chan, M.2    Liu, M.3
  • 21
    • 2142820093 scopus 로고    scopus 로고
    • Endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejection
    • Ghanekar A, Mendicino M, Liu H et al. Endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejection. J Immunol 2004 172 : 5693 5701.
    • (2004) J Immunol , vol.172 , pp. 5693-5701
    • Ghanekar, A.1    Mendicino, M.2    Liu, H.3
  • 22
    • 0028881851 scopus 로고
    • Complement-mediated regulation of tissue factor activity in endothelium
    • Saadi S, Holzknecht R, Patte C, Stern D, Platt J. Complement-mediated regulation of tissue factor activity in endothelium. J Exp Med 1995 182 : 1807 1814.
    • (1995) J Exp Med , vol.182 , pp. 1807-1814
    • Saadi, S.1    Holzknecht, R.2    Patte, C.3    Stern, D.4    Platt, J.5
  • 23
    • 33744987414 scopus 로고    scopus 로고
    • Generation of C5a in the absence of C3: A new complement activation pathway
    • Huber-Lang M, Sarma J, Zetoune F et al. Generation of C5a in the absence of C3: a new complement activation pathway. Nat Med 2006 12 : 682 687.
    • (2006) Nat Med , vol.12 , pp. 682-687
    • Huber-Lang, M.1    Sarma, J.2    Zetoune, F.3
  • 24
    • 0018411524 scopus 로고
    • C5 chemotactic fragment induces leukocyte production of tissue factor activity: A link between complement and coagulation
    • Muhlfelder T, Niemetz J, Kreutzer D et al. C5 chemotactic fragment induces leukocyte production of tissue factor activity: a link between complement and coagulation. J Clin Invest 1979 63 : 147 150.
    • (1979) J Clin Invest , vol.63 , pp. 147-150
    • Muhlfelder, T.1    Niemetz, J.2    Kreutzer, D.3
  • 25
    • 39549104720 scopus 로고    scopus 로고
    • Simultaneous activation of complement and coagulation by MBL-associated serine protease 2
    • Krarup A, Wallis R, Presanis J, Gál P, Sim R. Simultaneous activation of complement and coagulation by MBL-associated serine protease 2. PLoS ONE 2007 2 : e623.
    • (2007) PLoS ONE , vol.2 , pp. 623
    • Krarup, A.1    Wallis, R.2    Presanis, J.3    Gál, P.4    Sim, R.5
  • 26
    • 52949118458 scopus 로고    scopus 로고
    • Harmful molecular mechanisms in sepsis
    • Rittirsch D, Flierl M, Ward P. Harmful molecular mechanisms in sepsis. Nat Rev Immunol 2008 8 : 776 787.
    • (2008) Nat Rev Immunol , vol.8 , pp. 776-787
    • Rittirsch, D.1    Flierl, M.2    Ward, P.3
  • 27
    • 10744228498 scopus 로고    scopus 로고
    • Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen
    • Kuwaki K, Knosalla C, Dor F et al. Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen. Am J Transplant 2004 4 : 363 372.
    • (2004) Am J Transplant , vol.4 , pp. 363-372
    • Kuwaki, K.1    Knosalla, C.2    Dor, F.3
  • 28
    • 24644482765 scopus 로고    scopus 로고
    • Cardiac xenotransplantation: Recent preclinical progress with 3-month median survival
    • Mcgregor C, Davies W, Oi K et al. Cardiac xenotransplantation: recent preclinical progress with 3-month median survival. J Thorac Cardiovasc Surg 2005 130 : 844 851.
    • (2005) J Thorac Cardiovasc Surg , vol.130 , pp. 844-851
    • McGregor, C.1    Davies, W.2    Oi, K.3
  • 29
    • 37549030579 scopus 로고    scopus 로고
    • Reduced fibrin deposition and intravascular thrombosis in hDAF transgenic pig hearts perfused with tirofiban
    • Brandl U, Jöckle H, Erhardt M et al. Reduced fibrin deposition and intravascular thrombosis in hDAF transgenic pig hearts perfused with tirofiban. Transplantation 2007 84 : 1667 1676.
    • (2007) Transplantation , vol.84 , pp. 1667-1676
    • Brandl, U.1    Jöckle, H.2    Erhardt, M.3
  • 30
    • 0034705504 scopus 로고    scopus 로고
    • Molecular cloning of endo-beta-galactosidase C and its application in removing alpha-galactosyl xenoantigen from blood vessels in the pig kidney
    • Ogawa H, Muramatsu H, Kobayashi T et al. Molecular cloning of endo-beta-galactosidase C and its application in removing alpha-galactosyl xenoantigen from blood vessels in the pig kidney. J Biol Chem 2000 275 : 19368 19374.
    • (2000) J Biol Chem , vol.275 , pp. 19368-19374
    • Ogawa, H.1    Muramatsu, H.2    Kobayashi, T.3
  • 31
    • 0036558480 scopus 로고    scopus 로고
    • Enzymatic removal of alphaGal antigen in pig kidneys by ex vivo and in vivo administration of endo-beta-galactosidase C
    • Liu D, Kobayashi T, Yokoyama I et al. Enzymatic removal of alphaGal antigen in pig kidneys by ex vivo and in vivo administration of endo-beta-galactosidase C. Xenotransplantation 2002 9 : 228 236.
    • (2002) Xenotransplantation , vol.9 , pp. 228-236
    • Liu, D.1    Kobayashi, T.2    Yokoyama, I.3
  • 32
    • 0025884056 scopus 로고
    • Efficient selection for high-expression transfectants with a novel eukaryotic vector
    • Niwa H, Yamamura K, Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 1991 108 : 193 199.
    • (1991) Gene , vol.108 , pp. 193-199
    • Niwa, H.1    Yamamura, K.2    Miyazaki, J.3
  • 33
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak K, Schmittgen T. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001 25 : 402 408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.1    Schmittgen, T.2
  • 34
    • 0032030653 scopus 로고    scopus 로고
    • Protein C inhibitor acts as a procoagulant by inhibiting the thrombomodulin-induced activation of protein C in human plasma
    • Elisen M, Von Dem Borne P, Bouma B, Meijers J. Protein C inhibitor acts as a procoagulant by inhibiting the thrombomodulin-induced activation of protein C in human plasma. Blood 1998 91 : 1542 1547.
    • (1998) Blood , vol.91 , pp. 1542-1547
    • Elisen, M.1    Von Dem Borne, P.2    Bouma, B.3    Meijers, J.4
  • 35
    • 17644444057 scopus 로고    scopus 로고
    • Alpha-Galactosyl oligosaccharides conjugated with polyethylene glycol as potential inhibitors of hyperacute rejection upon xenotransplantation
    • Nagasaka T, Kobayashi T, Muramatsu H et al. alpha-Galactosyl oligosaccharides conjugated with polyethylene glycol as potential inhibitors of hyperacute rejection upon xenotransplantation. Biochem Biophys Res Commun 1997 232 : 731 736.
    • (1997) Biochem Biophys Res Commun , vol.232 , pp. 731-736
    • Nagasaka, T.1    Kobayashi, T.2    Muramatsu, H.3
  • 36
    • 0023629566 scopus 로고
    • Growth inhibition by protein kinase C late in mitogenesis
    • Huang C, Ives H. Growth inhibition by protein kinase C late in mitogenesis. Nature 1987 329 : 849 850.
    • (1987) Nature , vol.329 , pp. 849-850
    • Huang, C.1    Ives, H.2
  • 37
    • 0033613183 scopus 로고    scopus 로고
    • How the protease thrombin talks to cells
    • Coughlin S. How the protease thrombin talks to cells. Proc Natl Acad Sci USA 1999 96 : 11023 11027.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11023-11027
    • Coughlin, S.1
  • 38
    • 0022924087 scopus 로고
    • Thrombin-cellular interactions
    • Shuman M. Thrombin-cellular interactions. Ann N Y Acad Sci 1986 485 : 228 239.
    • (1986) Ann N y Acad Sci , vol.485 , pp. 228-239
    • Shuman, M.1
  • 39
    • 0023755932 scopus 로고
    • Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells
    • Conway E, Rosenberg R. Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells. Mol Cell Biol 1988 8 : 5588 5592.
    • (1988) Mol Cell Biol , vol.8 , pp. 5588-5592
    • Conway, E.1    Rosenberg, R.2
  • 40
    • 0025963529 scopus 로고
    • Regulation of thrombomodulin by tumor necrosis factor-alpha: Comparison of transcriptional and posttranscriptional mechanisms
    • Lentz S, Tsiang M, Sadler J. Regulation of thrombomodulin by tumor necrosis factor-alpha: comparison of transcriptional and posttranscriptional mechanisms. Blood 1991 77 : 542 550.
    • (1991) Blood , vol.77 , pp. 542-550
    • Lentz, S.1    Tsiang, M.2    Sadler, J.3
  • 41
    • 0020404408 scopus 로고
    • Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor v activation
    • Esmon C, Esmon N, Harris K. Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation. J Biol Chem 1982 257 : 7944 7947.
    • (1982) J Biol Chem , vol.257 , pp. 7944-7947
    • Esmon, C.1    Esmon, N.2    Harris, K.3
  • 42
    • 0021053984 scopus 로고
    • Thrombomodulin blocks the ability of thrombin to activate platelets
    • Esmon N, Carroll R, Esmon C. Thrombomodulin blocks the ability of thrombin to activate platelets. J Biol Chem 1983 258 : 12238 12242.
    • (1983) J Biol Chem , vol.258 , pp. 12238-12242
    • Esmon, N.1    Carroll, R.2    Esmon, C.3
  • 43
    • 0036719075 scopus 로고    scopus 로고
    • The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways
    • Conway E, Van De Wouwer M, Pollefeyt S et al. The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways. J Exp Med 2002 196 : 565 577.
    • (2002) J Exp Med , vol.196 , pp. 565-577
    • Conway, E.1    Van De Wouwer, M.2    Pollefeyt, S.3
  • 44
    • 20944436774 scopus 로고    scopus 로고
    • The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel anti inflammatory mechanism
    • Abeyama K, Stern D, Ito Y et al. The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel anti inflammatory mechanism. J Clin Invest 2005 115 : 1267 1274.
    • (2005) J Clin Invest , vol.115 , pp. 1267-1274
    • Abeyama, K.1    Stern, D.2    Ito, Y.3
  • 45
    • 0025254067 scopus 로고
    • Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex
    • Hamilton K, Hattori R, Esmon C, Sims P. Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex. J Biol Chem 1990 265 : 3809 3814.
    • (1990) J Biol Chem , vol.265 , pp. 3809-3814
    • Hamilton, K.1    Hattori, R.2    Esmon, C.3    Sims, P.4
  • 46
    • 33845993965 scopus 로고    scopus 로고
    • Relation between human decay-accelerating factor (hDAF) expression in pig cells and inhibition of human serum anti-pig cytotoxicity: Value of highly expressed hDAF for xenotransplantation
    • Liu D, Kobayashi T, Onishi A et al. Relation between human decay-accelerating factor (hDAF) expression in pig cells and inhibition of human serum anti-pig cytotoxicity: value of highly expressed hDAF for xenotransplantation. Xenotransplantation 2007 14 : 67 73.
    • (2007) Xenotransplantation , vol.14 , pp. 67-73
    • Liu, D.1    Kobayashi, T.2    Onishi, A.3
  • 47
    • 0036664209 scopus 로고    scopus 로고
    • Protective effects of recombinant human antithrombin III in pig-to-primate renal xenotransplantation
    • Cowan P, Aminian A, Barlow H et al. Protective effects of recombinant human antithrombin III in pig-to-primate renal xenotransplantation. Am J Transplant 2002 2 : 520 525.
    • (2002) Am J Transplant , vol.2 , pp. 520-525
    • Cowan, P.1    Aminian, A.2    Barlow, H.3
  • 48
    • 29144483474 scopus 로고    scopus 로고
    • Effects of long-term administration of high-dose recombinant human antithrombin in immunosuppressed primate recipients of porcine xenografts
    • Cozzi E, Simioni P, Boldrin M et al. Effects of long-term administration of high-dose recombinant human antithrombin in immunosuppressed primate recipients of porcine xenografts. Transplantation 2005 80 : 1501 1510.
    • (2005) Transplantation , vol.80 , pp. 1501-1510
    • Cozzi, E.1    Simioni, P.2    Boldrin, M.3
  • 49
    • 40549109937 scopus 로고    scopus 로고
    • Effects of pharmacological intervention on coagulopathy and organ function in xenoperfused kidneys
    • Ramackers W, Friedrich L, Tiede A et al. Effects of pharmacological intervention on coagulopathy and organ function in xenoperfused kidneys. Xenotransplantation 2008 15 : 46 55.
    • (2008) Xenotransplantation , vol.15 , pp. 46-55
    • Ramackers, W.1    Friedrich, L.2    Tiede, A.3
  • 50
    • 10044240662 scopus 로고    scopus 로고
    • Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium
    • Chen D, Weber M, Mcvey J et al. Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium. Am J Transplant 2004 4 : 1958 1963.
    • (2004) Am J Transplant , vol.4 , pp. 1958-1963
    • Chen, D.1    Weber, M.2    McVey, J.3
  • 51
  • 52
    • 51049088337 scopus 로고    scopus 로고
    • Generation of Gal knockout pig expressing human CD39
    • Salvaris E, Harrison S, Beebe L et al. Generation of Gal knockout pig expressing human CD39. Xenotransplantation 2007 14 : 417 418.
    • (2007) Xenotransplantation , vol.14 , pp. 417-418
    • Salvaris, E.1    Harrison, S.2    Beebe, L.3
  • 53
    • 33845513582 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: Results of a phase III, randomized, double-blind clinical trial
    • Saito H, Maruyama I, Shimazaki S et al. Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial. J Thromb Haemost 2007 5 : 31 41.
    • (2007) J Thromb Haemost , vol.5 , pp. 31-41
    • Saito, H.1    Maruyama, I.2    Shimazaki, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.