The role of anti-non-Gal antibodies in the development of acute humoral xenograft rejection of hDAF transgenic porcine kidneys in baboons receiving anti-Gal antibody neutralization therapy

Transplantation

Volumn 81, Issue 2, 2006, Pages 273-283

  Chen, Gang ^a,b   Sun, Hongtao ^a   Yang, Hongji ^a   Kubelik, Dalibor ^a   Garcia, Bertha ^a   Luo, Yigang ^a,c   Xiang, Ying ^a   Qian, Allen ^a   Copeman, Laura ^d   Liu, Weihua ^a   Cardella, Carl J ^e   Wang, Wanyu ^f   Xiong, Yuliang ^f   Wall, William ^c   White, David J ^d   Zhong, Robert ^a,c,d  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c LONDON HEALTH SCIENCES CENTRE   (Canada)

^d ROBARTS RESEARCH INSTITUTE   (Canada)

^e UNIVERSITY HEALTH NETWORK   (Canada)

^f KUNMING INSTITUTE OF ZOOLOGY   (China)

Author keywords

Baboon; Gal; Kidney; Pig; Xenotransplantation

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE ANTIBODY; ALPHA 1,3 GALACTOSYLTRANSFERASE POLYETHYLENE GLYCOL CONJUGATE; COMPLEMENT; DECAY ACCELERATING FACTOR; GAS 914; GLYCOCONJUGATE; HUMORAL ANTIBODY; IMMUNOGLOBULIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; IMMUNOSUPPRESSIVE AGENT; LF 15 0195; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NEUTRALIZING ANTIBODY; NON ALPHA 1,3 GALACTOSYLTRANSFERASE ANTIBODY; RITUXIMAB; SNAKE VENOM; THYMOCYTE ANTIBODY; TSUKUBAENOLIDE; UNCLASSIFIED DRUG; ALPHA GALACTOSYL EPITOPE; ALPHA-GALACTOSYL EPITOPE; HETEROPHILE ANTIBODY; TRISACCHARIDE;

ACUTE GRAFT REJECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; BABOON; CONTROLLED STUDY; CYTOTOXICITY; DRUG TOLERABILITY; ENDOTHELIUM CELL; FEMALE; FLOW CYTOMETRY; HUMORAL IMMUNITY; IMMUNOPATHOGENESIS; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LYMPHOCYTE; MALE; NONHUMAN; PRIORITY JOURNAL; SWINE; TRANSGENIC ANIMAL; XENOGRAFT; ACUTE DISEASE; ANIMAL; BIOSYNTHESIS; GRAFT REJECTION; IMMUNOLOGY; PAPIO; PATHOLOGY; SERODIAGNOSIS;

ACUTE DISEASE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIBODIES, HETEROPHILE; GRAFT REJECTION; KIDNEY TRANSPLANTATION; NEUTRALIZATION TESTS; PAPIO; SUS SCROFA; TRANSPLANTATION, HETEROLOGOUS; TRISACCHARIDES;

EID: 33644862221     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000188138.53502.de     Document Type: Article

References (29)

1. Galili U, Macher BA, Buehler J, Shohet SB. Human natural anti-alpha-galactosyl IgG. II. The specific recognition of alpha (1-3 ) -linked galactose residues. J Exp Med 1985; 162(2): 573.
2. Platt JL, Fischel RJ, Matas AJ, et al. Immunopathology of hyperacute xenograft rejection in a swine-to-primate model. Transplantation 1991; 52(2): 214.
3. Bhatti FN, Schmoeckel M, Zaidi A, et al. Three-month survival of HDAFF transgenic pig hearts transplanted into primates. Transplant Proc. 1999; 31(1-2): 958.
4. Diamond LE, Quinn CM, Martin MJ, et al. A human CD46 transgenic pig model system for the study of discordant xenotransplantation. Transplantation 2001; 71(1): 132.
5. Zhong R, Luo Y, Yang H, et al. Improvement in human decay accelerating factor transgenic porcine kidney xenograft rejection with intravenous administration of gas914, a polymeric form of alphaGAL. Transplantation 2003; 75(1): 10.
6. Cozzi E, Vial C, Ostlie D, et al. Maintenance triple immunosuppression with cyclosporin A, mycophenolate sodium and steroids allows prolonged survival of primate recipients of hDAF porcine renal xenografts. Xenotransplantation 2003; 10(4): 300.
7. Kozlowski T, Ierino FL, Lambrigts D, et al. Depletion of anti-Gal(alpha) 1-3Gal antibody in baboons by specific alpha-Gal immunoaffinity columns. Xenotransplantation 1998; 5(2): 122.
8. McKenzie IF, Patton K, Smit JA, et al. Definition and characterization of chicken Gal alpha(1,3)Gal antibodies. Transplantation 1999; 67(6): 864.
9. McGregor CG, Teotia SS, Byrne GW, et al. Cardiac xenotransplantation: progress toward the clinic. Transplantation 2004; 78(11): 1569.
10. Gollackner B, Goh SK, Qawi I, et al. Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity. Transplantation 2004; 77(11): 1735.
11. Lam TT, Paniagua R, Shivaram G, et al. Anti-non-Gal porcine endothelial cell antibodies in acute humoral xenograft rejection of hDAF-transgenic porcine hearts in cynomolgus monkeys. Xenotransplantation 2004; 11(6): 531.
12. Lai L, Kolber-Simonds D, Park KW, et al. Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 2002; 295(5557): 1089.
13. Kolber-Simonds D, Lai L, Watt SR, et al. Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations. Proc Natl Acad Sci U S A 2004; 101(19): 7335.
14. Dorling A. Clinical xenotransplantation: pigs might fly? Am J Transplant 2002; 2(8): 695.
15. Cozzi E, Tucker AW, Langford GA, et al. Characterization of pigs transgenic for human decay-accelerating factor. Transplantation 1997; 64(10): 1383.
16. Richards AC, Davies HF, McLaughlin ML, et al. Serum anti-pig antibodies as potential indicators of acute humoral xenograft rejection in pig-to-cynomolgus monkey kidney transplantation. Transplantation 2002; 73(6): 881.
17. Al-Hussein K, Al-Mukhalafi Z, Pyle HR, et al. Detection of xenoantibodies using a simple flow cytometric assay. Xenotransplantation 2001; 8(3): 172.
18. Carrillo A, Chamorro S, Rodriguez-Gago M, et al. Isolation and characterization of immortalized porcine aortic endothelial cell lines. Vet Immunol Immunopathol 2002; 89(1-2): 91.
19. Cooper DK. Xenoantigens and xenoantibodies. Xenotransplantation 1998; 5(1): 6.
20. Macchiarini P, Oriol R, Azimzadeh A, et al. Evidence of human non-alpha-galactosyl antibodies involved in the hyperacute rejection of pig lungs and their removal by pig organ perfusion. J Thorac Cardiovasc Surg 1998; 116(5): 831.
21. Miyata Y, Platt JL. Xeno - still stuck without alphaGal. Nat Biotechnol 2003; 21(4): 359.
22. Buhler L, Xu Y, Li W, et al. An investigation of the specificity of induced anti-pig antibodies in baboons. Xenotransplantation 2003; 10(1): 88.
23. Wang H, Hosiawa KA, Garcia B, et al. Treatment with a short course of LF 15-0195 and continuous cyclosporin A attenuates acute xenograft rejection in a rat-to-mouse cardiac transplantation model. Xenotransplantation 2003; 10(4): 325.
24. Wang H, Hosiawa KA, Garcia B, et al. Attenuation of acute xenograft rejection by short-term treatment with LF15-0195 and monoclonal antibody against CD45RB in a rat-to-mouse cardiac transplantation model. Transplantation 2003; 75(9): 1475.
25. Reichenspurner H, Hildebrandt A, Human PA, et al. 15-Deoxyspergualin for induction of graft nonreactivity after cardiac and renal allo-transplantation in primates. Transplantation 1990; 50(2): 181.
26. Yang H, Chen G, Kanai N, et al. Monotherapy with LF 15-0195, an analogue of 15-deoxyspergualin, significantly prolongs renal allograft survival in monkeys. Transplantation 2003; 75(8): 1166.
27. Kapelanski DP, Perelman MJ, Faber LA, et al. 15-Deoxyspergualin and primate heart transplantation. J Heart Transplant 1990; 9(6): 668.
28. Yamada K, Yazawa K, Shimizu A, et al. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3- galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med 2005; 11(1): 32.
29. Zhu A. Binding of human natural antibodies to nonalphaGal xenoantigens on porcine erythrocytes. Transplantation 2000; 69(11): 2422.