Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation

Journal of Clinical Investigation

Volumn 113, Issue 10, 2004, Pages 1440-1446

  Dwyer, Karen M ^a,b   Robson, Simon C ^c   Nandurkar, Harshal H ^a,b   Campbell, Duncan J ^b,d   Gock, Hilton ^a   Murray Segal, Lisa J ^a   Fisicaro, Nella ^a   Mysore, Tharun B ^a   Kaczmarek, Elzbieta ^c   Cowan, Peter J ^a,b   D'Apice, Anthony J F ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c HARVARD MEDICAL SCHOOL   (United States)

^d ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; CD39 ANTIGEN; NUCLEOSIDE DIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE; APYRASE; LEUKOCYTE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLEEDING; BLOOD VESSEL INJURY; CELL ACTIVATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE DELETION; GENE TRANSFER; GRAFT SURVIVAL; HEART TRANSPLANTATION; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; SOMATIC GENE THERAPY; THROMBOCYTE AGGREGATION; THROMBOEMBOLISM; THROMBOSIS; TRANSGENIC MOUSE; UPREGULATION; VASOCONSTRICTION; XENOGRAFT; ANIMAL; BLOOD; BONE MARROW TRANSPLANTATION; C57BL MOUSE; CBA MOUSE; GENE EXPRESSION; GENETICS; HISTOCOMPATIBILITY; HUMAN; IMMUNOLOGY; PHENOTYPE; PHYSIOLOGY; THROMBOCYTE;

ADENOSINE; ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATASES; ANIMALS; ANTIGENS, CD; APYRASE; BLOOD PLATELETS; BONE MARROW TRANSPLANTATION; GENE EXPRESSION; HUMANS; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; PHENOTYPE; THROMBOSIS; TRANSPLANTATION IMMUNOLOGY;

EID: 85047692190     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI19560     Document Type: Article

References (41)

1. Maliszewski, C.R., et al. 1994. The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization. J. Immunol. 153:3574-3583.
2. Kaczmarek, E., et al. 1996. Identification and characterization of CD39/vascular ATP diphosphohydrolase. J. Biol. Chem. 271:33116-33122.
3. Goepfert, C., et al. 2000. CD39 modulates endothelial cell activation and apoptosis. Mol. Med. 6:591-603.
4. Marcus, A.J., et al. 1991. Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase. Thromboregulation by endothelial cells. J. Clin. Invest. 88:1690-1696.
5. Marcus, A.J., et al. 1995. Thrombosis and inflammation as multicellular processes: significance of cell-cell interactions. Thromb. Haemost. 74:213-217.
6. Zimmermann, H. 1992. 5′-Nucleotidase: molecular structure and functional aspects. Biochem. J. 285:345-365.
7. Sesti, C., et al. 2002. Ectonucleotidase in cardiac sympathetic nerve endings modulates ATP-mediated feedback of norepinephrine release. J. Pharmacol. Exp. Ther. 300:605-611.
8. Platt, J.L., et al. 1990. Release of heparan sulfate from endothelial cells. Implications for pathogenesis of hyperacute rejection. J. Exp. Med. 171:1363-1368.
9. Moore, K.L., Esmon, C.T., and Esmon, N.L. 1989. Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. Blood. 73:159-165.
10. Bach, F.H., et al. 1994. Endothelial cell activation and thromboregulation during xenograft rejection. Immunol. Rev. 141:5-30.
11. Bach, F.H., Winkler, H., Ferran, C., Hancock, W.W., and Robson, S.C. 1996. Delayed xenograft rejection. Immunol. Today. 17:379-384.
12. Robson, S.C., et al. 1995. Role of endothelial cells in transplantation. Int. Arch Allergy Immunol. 106:305-322.
13. Siegel, J.B., et al. 1997. Xenogeneic endothelial cells activate human prothrombin. Transplantation. 64:888-896.
14. Kopp, C.W., et al. 1997. Effect of porcine endothelial tissue factor pathway inhibitor on human coagulation factors. Transplantation. 63:749-758.
15. Ierino, F.L., et al. 1998. Disseminated intravascular coagulation in association with the delayed rejection of pig-to-baboon renal xenografts. Transplantation. 66:1439-1450.
16. Cowan, P.J., et al. 2000. Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons. Transplantation. 69:2504-2515.
17. Buhler, L., et al. 2000. Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates. Transplantation. 70:1323-1331.
18. Robson, S.C., et al. 1997. Loss of ATP diphosphohydrolase activity with endothelial cell activation. J. Exp. Med. 185:153-163.
19. Wang, T.F., and Guidotti, G. 1996. CD39 is an ecto-(Ca2+,Mg2+)-apyrase. J. Biol. Chem. 271:9898-9901.
20. Koyamada, N., et al. 1996. Apyrase administration prolongs discordant xenograft survival. Transplantation. 62:1739-1743.
21. Imai, M., et al. 1999. Modulation of nucleoside [correction of nucleotide] triphosphate diphosphohydrolase-1 (NTPDase-1)cd39 in xenograft rejection. Mol. Med. 5:743-752.
22. Imai, M., et al. 2000. Recombinant adenoviral mediated CD39 gene transfer prolongs cardiac xenograft survival. Transplantation. 70:864-870.
23. Enjyoji, K., et al. 1999. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nat. Med. 5:1010-1017.
24. Chen, C.-G., et al, 1996. Reduction in Gal-α1,3-Gal epitope expression in transgenic mice expressing human H-transferase. Xenotransplantation. 3:69-75.
25. Cowan, P.J., et al. 2002. Protective effects of recombinant human antithrombin III in pig-to-primate renal xenotransplantation. Am. J. Transplant. 2:520-525.
26. Marcus, A.J., et al. 1982. Formation of leukotrienes and other hydroxy acids during platelet-neutrophil interactions in vitro. Biochem. Biophys. Res. Commun. 109:130-137.
27. Zimmermann, H., and Braun, N. 1999. Ecto-nucleotidases-molecular structures, catalytic properties, and functional roles in the nervous system. Prog. Brain Res. 120:371-385.
28. Liang, B.T., and Jacobson, K.A. 1998. A physiological role of the adenosine A3 receptor: sustained cardioprotection. Proc. Natl. Acad. Sci. U. S. A. 95:6995-6999.
29. Sato, T., Sasaki, N., O'Rourke, B., and Marban, E. 2000. Adenosine primes the opening of mitochondrial ATP-sensitive potassium channels: a key step in ischemic preconditioning? Circulation. 102:800-805.
30. von Kugelgen, I., Allgaier, C., Schobert, A., and Starke, K. 1994. Co-release of noradrenaline and ATP from cultured sympathetic neurons. Neuroscience. 61:199-202.
31. Pinsky, D.J., et al. 2002. Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain. J. Clin. Invest. 109:1031-1040. doi: 10.1172/JC1200210649.
32. Fabre, J.E., et al. 1999. Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice. Nat. Med. 5:1199-1202.
33. Leon, C., et al. 1999. Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice. J. Clin. Invest. 104:1731-1737.
34. Kroll, M.H., and Schafer, A.I. 1989. Biochemical mechanisms of platelet activation. Blood. 74:1181-1198.
35. Van Deijnen, J.H., van Suylichem, P.T., Wolters, G.H., and van Schilfgaarde, R. 1994. Distribution of collagens type I, type III and type V in the pancreas of rat, dog, pig and man. Cell Tissue Res. 277:115-121.
36. van Suylichem, P.T., van Deijnen, J.E., Wolters, G.H., and van Schilfgaarde, R. 1995. Amount and distribution of collagen in pancreatic tissue of different species in the perspective of islet isolation procedures. Cell Transplant, 4:609-614.
37. Gewirtz, H., Brown, P., and Most, A.S. 1987. Measurement of plasma adenosine concentration: methodological and physiological considerations. Proc. Soc. Exp. Biol. Med. 185:93-100.
38. Merion, R.M., White, D.J., Thiru, S., Evans, D.B., and Calne, R.Y. 1984. Cyclosporine: five years' experience in cadaveric renal transplantation. N. Engl. J. Med. 310:148-154.
39. Candinas, D., et al. 1996. Inhibition of platelet integrin GPIIbIIIa prolongs survival of discordant cardiac xenografts. Transplantation. 62:1-5.
40. Imai, M., et al. 1999. Suppression of ATP diphosphohydrolase/CD39 in human vascular endothelial cells. Biochemistry. 18:13473-13479.
41. Saadjian, A.Y., et al. 2002. Role of endogenous adenosine as a modulator of syncope induced during tilt testing. Circulation. 106:569-574.