The pig analogue of CD59 protects transgenic mouse hearts from injury by human complement

Transplantation

Volumn 70, Issue 6, 2000, Pages 963-968

  Fisicaro, Nella ^a   Aminian, Atousa ^a   Hinchliffe, Stewart J ^b   Morgan, B Paul ^b   Pearse, Martin J ^a,c   D'Apice, Anthony J F ^a   Cowan, Peter J ^a  

^a ST VINCENT S HOSPITAL   (Australia)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c CSL LIMITED   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD59 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 2; REGULATOR PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CYTOKINE RELEASE; GRAFT REJECTION; HEART PROTECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; MOUSE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; SWINE; XENOGRAFT;

EID: 0034721478     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200009270-00014     Document Type: Article

References (27)

1. Barriers to xenotransplantation
2. A perspective on xenotransplantation
3. Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor - Potential for prevention of xenograft hyperacute rejection
4. Discordant organ xenotransplantation in primates
5. Transgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damage
6. Characterization in vitro and in vivo of the pig analogue of human CD59 using new monoclonal antibodies
7. Complement-inhibiting activities of human CD59 and analogues from rat, sheep and pig are not homologously restricted
8. Molecular cloning and functional characterization of the pig analogue of CD59: Relevance to xenotransplantation
9. Structure/function characterization of porcine CD59
10. Targeting gene expression to endothelial cells in transgenic mice using the human intercellular adhesion molecule 2 promoter
11. High-level endothelial expression of human CD59 prolongs heart function in an ex vivo model of xenograft rejection
12. High-level co-expression of complement regulators on vascular endothelium in transgenic mice: CD55 and CD59 provide greater protection from human complement-mediated injury than CD59 alone
13. Identification of the components of glomerular immune deposits using monoclonal antibodies
14. Knock-out of α1,3 galactosyltransferase or expression of α1,2 fucosyltransferase further protects CD55- and CD59-expressing mouse hearts in an ex vivo model of xenograft rejection
15. 20KDa homologous restriction factor of complement resembles T cell activating protein
16. Distribution of membrane cofactor protein (MCP/CD46) on pig tissues. Relevance to xenotransplantation
17. CD59 expressed by human endothelial cells functions as a protective molecule against complement-mediated lysis
18. Decay-accelerating factor is present on cultured human umbilical vein endothelial cells
19. Purification and characterization of the pig analogue of human membrane cofactor protein (CD46/MCP)
20. Expression and functional analysis of glycosyl-phosphatidyl inositol- linked CD46 in transgenic mice
21. Resistance against the membrane attack complex of complement induced in porcine endothelial cells with a galα(1,3)gal binding lectin: Upregulation of CD59 expression
22. The human CD46 molecule is a receptor for measles virus (Edmonston strain)
23. Decay-accelerating factor CD55 is identified as the receptor for echovirus 7 using CELICS, a rapid immune-focal cloning method
24. Coxsackievirus B3 adapted to growth in RD cells binds to decay-accelerating factor (CD55)
25. Transgenic pigs and virus adaptation
26. CD59 molecule - A 2nd ligand for CD2 in T-cell adhesion