O-linked glycosylation and functional incompatibility of porcine von Willebrand factor for human platelet GPIb receptors

Xenotransplantation

Volumn 12, Issue 1, 2005, Pages 30-37

  Schulte Am Esch II, J ^a   Robson, Simon C ^b   Knoefel, Wolfram T ^a   Hosch, Stefan B ^a   Rogiers, Xavier ^c  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Coagulation; Glycosylation; GPIb; Molecular incompatibility; Platelets; Von Willebrand factor; Xenotranplantation

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; BLOOD CLOTTING FACTOR; EPITOPE; GLYCOPROTEIN IB; N ACETYLGALACTOSAMINE; PHENYL ALPHA 2 N ACETYLGALACTOSAMINE; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

ANIMAL CELL; ARTICLE; BLOOD CLOTTING; BLOOD VESSEL INJURY; CELL MEMBRANE; CELL STRAIN COS7; CONTROLLED STUDY; FLOW CYTOMETRY; GLYCOSYLATION; GRAFT REJECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SWINE; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTOPENIA; VASCULITIS; WESTERN BLOTTING; XENOGRAFT; XENOTRANSPLANTATION;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; EPITOPES; GLYCOSYLATION; GRAFT REJECTION; HUMANS; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SWINE; TRANSPLANTATION, HETEROLOGOUS; VON WILLEBRAND FACTOR;

EID: 12144279878     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2004.00187.x     Document Type: Article

References (46)

1. SCHULTE Am ESCH J, ROGIERS X, ROBSON SC. Molecular incompatibilities in hemostasis between swine and men-impact on xenografting. Ann Transplant 2001; 6: 12.
2. GIRMA JP, MEYER D, VERWEIJ CL, PANNEKOEK H, SIXMA JJ. Structure-function relationship of human von Willebrand factor. Blood 1987; 70: 605.
3. TURITTO VT, WEISS HJ, ZIMMERMAN TS, SUSSMAN II. Factor VIII/von Willebrand factor in subendothelium mediates platelet adhesion. Blood 1985; 65: 823.
4. PETERSON DM, STATHOPOULOS NA, GIORGIO TD, HELLUMS JD, MOAKE JL. Shear-induced platelet aggregation requires von Willebrand factor and platelet membrane glycoproteins Ib and IIb-IIIa. Blood 1987; 69: 625.
5. KAWAKAMI K, FUKUYAMA M, SAKAI K et al. Change in intracellular calcium ions during shear induced platelet aggregation. ASAIO Trans 1990; 36: M696.
6. FRESSINAUD E, MEYER D. von Willebrand factor and platelet interactions with the vessel wall. Blood Coagul Fibrinolysis 1991; 2: 333.
7. VERWEIJ CL, DIERGAARDE PJ, HART M, PANNEKOEK H. Willebrand factor (vWF) cDNA encodes a highly repetitive protein considerably larger than the mature vWF subunit. EMBO J 1986; 5: 1839.
8. RUGGERI ZM. von Willebrand factor as a target for antithrombotic intervention. Circulation 1992; 86: III26.
9. FUJIMURA Y, TITANI K, HOLLAND LZ et al. von Willebrand factor, a reduced and alkylated 52/48-kDa fragment beginning at amino acid residue 449 contains the domain interacting with platelet glycoprotein Ib. J Biol Chem 1986; 261: 381.
10. ANDREWS RK, GORMAN JJ, BOOTH WJ et al. Cross-linking of a monomeric 39/34-kDa dispase fragment of von Willebrand factor (Leu-480/Val-481-Gly-718) to the N-terminal region of the membrane glycoprotein Ib on intact platelets with suberate. Biochemistry (Mosc) 1989; 28: 8326.
11. PIETU G, MEULIEN P, CHEREL G et al. Production in Escherichia coli of a biologically active subfragment of von Willebrand factor corresponding to the platelet glycoprotein Ib, collagen and heparin binding domains. Biochem Biophys Res Commun 1989; 164: 1339.
12. CRUZ MA, HANDIN RI, WISE RJ. The interaction of the von Willebrand factor-A1 domain with platelet glycoprotein Ib/IX. The role of glycosylation and disulfide bonding in a monomeric recombinant Al domain protein. J Biol Chem 1993; 268: 21238.
13. FORBES CD, BARR RD, MCNICOL GP, DOUGLAS AS. Aggregation of human platelets by commercial preparations of bovine and porcine antihaemophilic globulin. J Clin Pathol 1972; 25: 210.
14. ALTIERI DC, CAPITANIO AM, MANNUCCI PM. von Willebrand factor contaminating porcine actor Viii concentrate (Hyate:C) causes platelet aggregation. Br J Haematol 1986; 63: 703.
15. LAU CL, CANTU E, GONZALEZ-STAWINSKI GV et al. The role of antibodies and von Willebrand factor in discordant pulmonary xenotransplantation. Am J Transplant 2003; 3: 1065.
16. CHAN JY, OWEN CA Jr, BOWIE EJ et al. Von Willebrand disease "stimulating factor" in porcine plasma. Am J Physiol 1968; 214: 1219.
17. PARETI FI, MAZZUCATO M, BOTTINI E, MANNUCCI PM. Interaction of porcine von Willebrand factor with the platelet glycoproteins Ib and IIb/IIIa complex. Br J Haematol 1992; 82: 81.
18. MAZZUCATO M, DE MARCO L, PRADELLA P, MASOTTI A, PARETI FI. Willebrand factor binding to human platelet GPIb induces transmembrane calcium influx. Thromb Haemost 1996; 75: 655.
19. SCHULTE AM ESCH J, CRUZ MA, SIEGEL JB, ANRATHER J, ROBSON SC. Activation of human platelets by the membrane-expressed A1 domain of von Willebrand factor. Blood 1997; 90: 4425.
20. DE MARCO L, SHAPIRO SS. Properties of human asialo-factor VIII. A ristocetin-independent platelet-aggregating agent. J Clin Invest 1981; 68: 321.
21. DE MARCO L, GIROLAMI A, RUSSELL S, RUGGERI ZM. Interaction of asialo von Willebrand factor with glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and mediates platelet aggregation. J Clin Invest 1985; 75: 1198.
22. GRAINICK HR, WILLIAMS SB, COLLER ES. Willebrand factor interactions with platelets. Interdependence of glycoproteins Ib and IIb/IIIa for binding and aggregation. J Clin Invest 1985; 75: 19.
23. SCHULTE AM ESCH J, ROBSON SC, CRUZ MA. Platelet aggregation by membrane-expressed A1 domains of von Willebrand Factor is dependent on residues Asp 560 and Gly 561. Biochem Biophys Res Commun 2003; 302: 877.
24. BERNDT MC, MOORE L, NOVELLO P et al Epitope mapping of monoclonal anti-vWF A1 domain antibodies reveals distinct regions involved in ristocetin and botrocetin dependent binding of vWF to platelet GPIb. Blood 2002; 100: 979.
25. HANSEN JE, LUND O, TOLSTRUP N et al. NetOglyc: Prediction of mucin type O-glycosylation sites based on sequence context and surface accessibility. Glycoconj J 1998; 15: 115.
26. HANSEN JE, LUND O, ENGELBRECHT J et al. Prediction of O-glycosylation of mammalian proteins: Specificity patterns of UDP-GalNAc:-polypeptide N-acetylgalactosaminyltransferase. Biochem J 1995; 308: 801.
27. HANSEN JE, LUND O, NIELSEN JO, BRUNAK S. O-GLYCBASE: a revised database of O-glycosylated proteins. Nucleic Acids Res 1996; 24: 248.
28. HANSEN JE, LUND O, RAPACKI K, BRUNAK S. O-glycbase version 2.0 - a revised database of O-glycosylated proteins. Nucleic Acids Res 1997; 25: 278.
29. TITANI K, TAKIO K, HANDA M, RUGGERI ZM. Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Proc Natl Acad Sci U S A 1987; 84: 5610.
30. KUAN SF, BYRD JC, BASBAUM C, KIM YS. Inhibition of mucin glycosylation by aryl-N-acetyl-alpha-galactosaminides in human colon cancer cells. J Biol Chem 1989; 264: 19271.
31. DASGUPTA A, TAKAHASHI K, CUTLER M, TANABE KK. O-linked glycosylation modifies CD44 adhesion to hyaluronate in colon carcinoma cells. Biochem Biophys Res Commun 1996; 227: 110.
32. SCHULTE AM ESCH J, SEVIGNY J, KACZMAREK E et al. Structural elements and limited proteolysis of CD39 influence ATP diphosphohydrolase activity. Biochemistry (Mosc) 1999; 38: 2248.
33. GUPTA R, BIRCH H, RAPACKI K, BRUNAK S, HANSEN JE. O-GLYCBASE version 4.0: a revised database of O-glycosylated proteins. Nucleic Acids Res 1999; 27: 370.
34. NAKAHARA Y, MIYATA T, HAMURO T et al. Amino acid sequence and carbohydrate structure of a recombinant human tissue factor pathway inhibitor expressed in Chinese hamster ovary cells: one N-and two O-linked carbohydrate chains are located between Kunitz domains 2 and 3 and one N-linked carbohydrate chain is in Kunitz domain 2. Biochemistry (Mosc) 1996; 35: 6450.
35. BJOERN S, FOSTER DC, THIM L et al. Human plasma and recombinant factor VII. Characterization of O-glycosylations at serine residues 52 and 60 and effects of site-directed mutagenesis of serine 52 to alanine. J Biol Chem 1991; 266: 11051.
36. AGARWALA KL, KAWABATA S, TAKAO T et al. Activation peptide of human factor IX has oligosaccharides O-glycosidically linked to threonine residues at 159 and 169. Biochemistry (Mosc) 1994; 33: 5167.
37. NISHIMURA H, TAKAO T, HASE S, SHIMONISHI Y, IWANAGA S. Human factor IX has a tetrasaccharide O-glycosidically linked to serine 61 through the fucose residue. J Biol Chem 1992; 267: 17520.
38. INOUE K, MORITA T. Identification of O-linked oligosaccharide chains in the activation peptides of blood coagulation factor X. The role of the carbohydrate moieties in the activation of factor X. Eur J Biochem 1993; 218: 153.
39. HARRIS RJ, LING VT, SPELLMAN MW. O-linked fucose is present in the first epidermal growth factor domain of factor XII but not protein C. J Biol Chem 1992; 267: 5102.
40. MATSUSHITA T, SADLER JE. Identification of amino acid residues essential for von Willebrand factor binding to platelet glycoprotein Ib. Charged-to-alanine scanning mutagenesis of the A1 domain of human von Willebrand factor. J Biol Chem 1995; 270: 13406.
41. CAREW JA, QUINN SM, STODDART JH, LYNCH DC. O-linked carbohydrate of recombinant von Willebrand factor influences ristocetin-induced binding to platelet glycoprotein 1b. J Clin Invest 1992; 90: 2258.
42. SCOTT JP, MONTGOMERY RR, RETZINGER GS. Dimeric ristocetin flocculates proteins, binds to platelets, and mediates von Willebrand factor-dependent agglutination of platelets. J Biol Chem 1991; 266: 8149.
43. EMSLEY J, CRUZ M, HANDIN R, LIDDINGTON R. Crystal structure of the von Willebrand Factor Al domain and implications for the binding of platelet glycoprotein Ib. J Biol Chem 1998; 273: 10396.
44. NAKAYAMA T, MATSUSHITA T, DONG Z et al. Identification of the regulatory elements of the human von Willebrand factor for binding to platelet GPIb. Importance of structural integrity of the regions flanked by the CYS1272-CYS1458 disulfide bond. J Biol Chem 2002; 277: 22063.
45. HUIZINGA EG, TSUJI S, ROMIJN RA et al. Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain. Science 2002; 297: 1176.
46. EVANS RJ, AUSTEN DE. Assay and characterization of the factor in porcine and bovine plasma which aggregates human platelets. Br J Haematol 1977; 36: 117.