-
1
-
-
84855792427
-
Cancer statistics, 2012
-
Siegel, R.; Naishadham, D.; Jemal, A. Cancer statistics, 2012. CA Cancer J. Clin. 2012, 62, 10-29.
-
(2012)
CA Cancer J. Clin
, vol.62
, pp. 10-29
-
-
Siegel, R.1
Naishadham, D.2
Jemal, A.3
-
2
-
-
79952232216
-
Global cancer statistics
-
Jemal, A.; Bray, F.; Center, M.M.; Ferlay, J.; Ward, E.; Forman, D. Global cancer statistics. CA Cancer J. Clin. 2011, 61, 69-90.
-
(2011)
CA Cancer J. Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
3
-
-
84859212951
-
Hepatocellular carcinoma
-
Forner, A.; Llovet, J.M.; Bruix, J. Hepatocellular carcinoma. Lancet 2012, 379, 1245-1255.
-
(2012)
Lancet
, vol.379
, pp. 1245-1255
-
-
Forner, A.1
Llovet, J.M.2
Bruix, J.3
-
4
-
-
73149120271
-
Metabolic syndrome and hepatocellular carcinoma: Two growing epidemics with a potential link
-
Siegel, A.B.; Zhu, A.X. Metabolic syndrome and hepatocellular carcinoma: Two growing epidemics with a potential link. Cancer 2009, 115, 5651-5661.
-
(2009)
Cancer
, vol.115
, pp. 5651-5661
-
-
Siegel, A.B.1
Zhu, A.X.2
-
5
-
-
0033545541
-
Rising incidence of hepatocellular carcinoma in the United States
-
El-Serag, H.B.; Mason, A.C. Rising incidence of hepatocellular carcinoma in the United States. N. Engl. J. Med. 1999, 340, 745-750.
-
(1999)
N. Engl. J. Med
, vol.340
, pp. 745-750
-
-
El-Serag, H.B.1
Mason, A.C.2
-
6
-
-
34250020201
-
Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
-
El-Serag, H.B.; Rudolph, K.L. Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology 2007, 132, 2557-2576.
-
(2007)
Gastroenterology
, vol.132
, pp. 2557-2576
-
-
El-Serag, H.B.1
Rudolph, K.L.2
-
7
-
-
84856429876
-
Obesity Inflammation, and liver cancer
-
Sun, B.; Karin, M. Obesity, inflammation, and liver cancer. J. Hepatol. 2012, 56, 704-713.
-
(2012)
J. Hepatol
, vol.56
, pp. 704-713
-
-
Sun, B.1
Karin, M.2
-
9
-
-
79957449923
-
Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008
-
Younossi, Z.M.; Stepanova, M.; Afendy, M.; Fang, Y.; Younossi, Y.; Mir, H.; Srishord, M. Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008. Clin. Gastroenterol. Hepatol. 2011, 9, 524-530.
-
Clin. Gastroenterol. Hepatol
, vol.2011
, Issue.9
, pp. 524-530
-
-
Younossi, Z.M.1
Stepanova, M.2
Afendy, M.3
Fang, Y.4
Younossi, Y.5
Mir, H.6
Srishord, M.7
-
10
-
-
84861197159
-
Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace
-
Baffy, G.; Brunt, E.M.; Caldwell, S.H. Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace. J. Hepatol. 2012, 56, 1384-1391.
-
(2012)
J. Hepatol
, vol.56
, pp. 1384-1391
-
-
Baffy, G.1
Brunt, E.M.2
Caldwell, S.H.3
-
11
-
-
79959517565
-
Human fatty liver disease: Old questions and new insights
-
Cohen, J.C.; Horton, J.D.; Hobbs, H.H. Human fatty liver disease: Old questions and new insights. Science 2011, 332, 1519-1523.
-
(2011)
Science
, vol.332
, pp. 1519-1523
-
-
Cohen, J.C.1
Horton, J.D.2
Hobbs, H.H.3
-
12
-
-
74549167737
-
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
-
Park, E.J.; Lee, J.H.; Yu, G.Y.; He, G.; Ali, S.R.; Holzer, R.G.; Osterreicher, C.H.; Takahashi, H.; Karin, M. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010, 140, 197-208.
-
(2010)
Cell
, vol.140
, pp. 197-208
-
-
Park, E.J.1
Lee, J.H.2
Yu, G.Y.3
He, G.4
Ali, S.R.5
Holzer, R.G.6
Osterreicher, C.H.7
Takahashi, H.8
Karin, M.9
-
13
-
-
84867707157
-
Inflammation- and stress-related signaling pathways in hepatocarcinogenesis
-
Nakagawa, H.; Maeda, S. Inflammation- and stress-related signaling pathways in hepatocarcinogenesis. World J. Gastroenterol. 2012, 18, 4071-4081.
-
(2012)
World J. Gastroenterol
, vol.18
, pp. 4071-4081
-
-
Nakagawa, H.1
Maeda, S.2
-
14
-
-
77952730428
-
The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
-
Ascha, M.S.; Hanouneh, I.A.; Lopez, R.; Tamimi, T.A.; Feldstein, A.F.; Zein, N.N. The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology 2010, 51, 1972-1978.
-
(2010)
Hepatology
, vol.51
, pp. 1972-1978
-
-
Ascha, M.S.1
Hanouneh, I.A.2
Lopez, R.3
Tamimi, T.A.4
Feldstein, A.F.5
Zein, N.N.6
-
15
-
-
0037076025
-
Prevalence of impaired glucose tolerance among children and adolescents with marked obesity
-
Sinha, R.; Fisch, G.; Teague, B.; Tamborlane, W.V.; Banyas, B.; Allen, K.; Savoye, M.; Rieger, V.; Taksali, S.; Barbetta, G., et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N. Engl. J. Med. 2002, 346, 802-810.
-
(2002)
N. Engl. J. Med
, vol.346
, pp. 802-810
-
-
Sinha, R.1
Fisch, G.2
Teague, B.3
Tamborlane, W.V.4
Banyas, B.5
Allen, K.6
Savoye, M.7
Rieger, V.8
Taksali, S.9
Barbetta, G.10
-
16
-
-
84890562275
-
Hepatocellular cancer-The impact of obesity, type 2 diabetes and a multidisciplinary team
-
Dyson, J.; Jaques, B.; Chattopadyhay, D.; Lochan, R.; Graham, J.; Das, D.; Aslam, T.; Patanwala, I.; Gaggar, S.; Cole, M. Hepatocellular cancer-The impact of obesity, type 2 diabetes and a multidisciplinary team. J. Hepatol. 2014, 60, 110-117.
-
(2014)
J. Hepatol
, vol.60
, pp. 110-117
-
-
Dyson, J.1
Jaques, B.2
Chattopadyhay, D.3
Lochan, R.4
Graham, J.5
Das, D.6
Aslam, T.7
Patanwala, I.8
Gaggar, S.9
Cole, M.10
-
17
-
-
3543072186
-
Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms
-
Calle, E.E.; Kaaks, R. Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms. Nat. Rev. Cancer 2004, 4, 579-591.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 579-591
-
-
Calle, E.E.1
Kaaks, R.2
-
18
-
-
0037464510
-
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
-
Calle, E.E.; Rodriguez, C.; Walker-Thurmond, K.; Thun, M.J. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N. Engl. J. Med. 2003, 348, 1625-1638.
-
(2003)
N. Engl. J. Med
, vol.348
, pp. 1625-1638
-
-
Calle, E.E.1
Rodriguez, C.2
Walker-Thurmond, K.3
Thun, M.J.4
-
19
-
-
0036714218
-
Overweight, obesity, and cancer risk
-
Bianchini, F.; Kaaks, R.; Vainio, H. Overweight, obesity, and cancer risk. Lancet Oncol. 2002, 3, 565-574.
-
(2002)
Lancet Oncol
, vol.3
, pp. 565-574
-
-
Bianchini, F.1
Kaaks, R.2
Vainio, H.3
-
20
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil, G.S. Inflammation and metabolic disorders. Nature 2006, 444, 860-867.
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
21
-
-
84876438500
-
The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001
-
De Angel, R.E.; Conti, C.J.; Wheatley, K.E.; Brenner, A.J.; Otto, G.; Degraffenried, L.A.; Hursting, S.D. The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001. Mol. Carcinog. 2013, 52, 446-458.
-
(2013)
Mol. Carcinog
, vol.52
, pp. 446-458
-
-
de Angel, R.E.1
Conti, C.J.2
Wheatley, K.E.3
Brenner, A.J.4
Otto, G.5
Degraffenried, L.A.6
Hursting, S.D.7
-
22
-
-
79957902145
-
Gut microbiome, obesity, and metabolic dysfunction
-
Tilg, H.; Kaser, A. Gut microbiome, obesity, and metabolic dysfunction. J. Clin. Investig. 2011, 121, 2126-2132.
-
(2011)
J. Clin. Investig
, vol.121
, pp. 2126-2132
-
-
Tilg, H.1
Kaser, A.2
-
23
-
-
33847040759
-
Increased intestinal permeability in obese mice: New evidence in the pathogenesis of nonalcoholic steatohepatitis
-
Brun, P.; Castagliuolo, I.; di Leo, V.; Buda, A.; Pinzani, M.; Palu, G.; Martines, D. Increased intestinal permeability in obese mice: New evidence in the pathogenesis of nonalcoholic steatohepatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 2007, 292, G518-G525.
-
(2007)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.292
-
-
Brun, P.1
Castagliuolo, I.2
di Leo, V.3
Buda, A.4
Pinzani, M.5
Palu, G.6
Martines, D.7
-
24
-
-
34347399563
-
Metabolic endotoxemia initiates obesity and insulin resistance
-
Cani, P.D.; Amar, J.; Iglesias, M.A.; Poggi, M.; Knauf, C.; Bastelica, D.; Neyrinck, A.M.; Fava, F.; Tuohy, K.M.; Chabo, C., et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007, 56, 1761-1772.
-
(2007)
Diabetes
, vol.56
, pp. 1761-1772
-
-
Cani, P.D.1
Amar, J.2
Iglesias, M.A.3
Poggi, M.4
Knauf, C.5
Bastelica, D.6
Neyrinck, A.M.7
Fava, F.8
Tuohy, K.M.9
Chabo, C.10
-
25
-
-
48249125862
-
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
-
Cani, P.D.; Bibiloni, R.; Knauf, C.; Waget, A.; Neyrinck, A.M.; Delzenne, N.M.; Burcelin, R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008, 57, 1470-1481.
-
(2008)
Diabetes
, vol.57
, pp. 1470-1481
-
-
Cani, P.D.1
Bibiloni, R.2
Knauf, C.3
Waget, A.4
Neyrinck, A.M.5
Delzenne, N.M.6
Burcelin, R.7
-
26
-
-
47949095562
-
Susceptibility to gut leakiness: A possible mechanism for endotoxaemia in non-alcoholic steatohepatitis
-
Farhadi, A.; Gundlapalli, S.; Shaikh, M.; Frantzides, C.; Harrell, L.; Kwasny, M.M.; Keshavarzian, A. Susceptibility to gut leakiness: A possible mechanism for endotoxaemia in non-alcoholic steatohepatitis. Liver Int. 2008, 28, 1026-1033.
-
(2008)
Liver Int
, vol.28
, pp. 1026-1033
-
-
Farhadi, A.1
Gundlapalli, S.2
Shaikh, M.3
Frantzides, C.4
Harrell, L.5
Kwasny, M.M.6
Keshavarzian, A.7
-
27
-
-
43049161319
-
Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: Role of endotoxin
-
Bergheim, I.; Weber, S.; Vos, M.; Krämer, S.; Volynets, V.; Kaserouni, S.; McClain, C.J.; Bischoff, S.C. Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: Role of endotoxin. J. Hepatol. 2008, 48, 983-992.
-
(2008)
J. Hepatol
, vol.48
, pp. 983-992
-
-
Bergheim, I.1
Weber, S.2
Vos, M.3
Krämer, S.4
Volynets, V.5
Kaserouni, S.6
McClain, C.J.7
Bischoff, S.C.8
-
28
-
-
70049099845
-
Immune responses to the microbiota at the intestinal mucosal surface
-
Duerkop, B.A.; Vaishnava, S.; Hooper, L.V. Immune responses to the microbiota at the intestinal mucosal surface. Immunity 2009, 31, 368-376.
-
(2009)
Immunity
, vol.31
, pp. 368-376
-
-
Duerkop, B.A.1
Vaishnava, S.2
Hooper, L.V.3
-
29
-
-
40049097359
-
Liver cirrhosis
-
Schuppan, D.; Afdhal, N.H. Liver cirrhosis. Lancet 2008, 371, 838-851.
-
(2008)
Lancet
, vol.371
, pp. 838-851
-
-
Schuppan, D.1
Afdhal, N.H.2
-
30
-
-
40149099357
-
Bacterial infections, sepsis, and multiorgan failure in cirrhosis
-
Tandon, P.; Garcia-Tsao, G. Bacterial infections, sepsis, and multiorgan failure in cirrhosis. Semin. Liver Dis. 2008, 28, 26-42.
-
(2008)
Semin. Liver Dis
, vol.28
, pp. 26-42
-
-
Tandon, P.1
Garcia-Tsao, G.2
-
31
-
-
0035133561
-
Bacterial translocation of enteric organisms in patients with cirrhosis
-
Cirera, I.; Bauer, T.M.; Navasa, M.; Vila, J.; Grande, L.; Taura, P.; Fuster, J.; Garcia-Valdecasas, J.C.; Lacy, A.; Suarez, M.J., et al. Bacterial translocation of enteric organisms in patients with cirrhosis. J. Hepatol. 2001, 34, 32-37.
-
(2001)
J. Hepatol
, vol.34
, pp. 32-37
-
-
Cirera, I.1
Bauer, T.M.2
Navasa, M.3
Vila, J.4
Grande, L.5
Taura, P.6
Fuster, J.7
Garcia-Valdecasas, J.C.8
Lacy, A.9
Suarez, M.J.10
-
32
-
-
43549107065
-
Energy intake is associated with endotoxemia in apparently healthy men
-
Amar, J.; Burcelin, R.; Ruidavets, J.B.; Cani, P.D.; Fauvel, J.; Alessi, M.C.; Chamontin, B.; Ferriéres, J. Energy intake is associated with endotoxemia in apparently healthy men. Am. J. Clin. Nutr. 2008, 87, 1219-1223.
-
(2008)
Am. J. Clin. Nutr
, vol.87
, pp. 1219-1223
-
-
Amar, J.1
Burcelin, R.2
Ruidavets, J.B.3
Cani, P.D.4
Fauvel, J.5
Alessi, M.C.6
Chamontin, B.7
Ferriéres, J.8
-
33
-
-
49449083979
-
Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake
-
Thuy, S.; Ladurner, R.; Volynets, V.; Wagner, S.; Strahl, S.; Königsrainer, A.; Maier, K.-P.; Bischoff, S.C.; Bergheim, I. Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. J. Nutr. 2008, 138, 1452-1455.
-
(2008)
J. Nutr
, vol.138
, pp. 1452-1455
-
-
Thuy, S.1
Ladurner, R.2
Volynets, V.3
Wagner, S.4
Strahl, S.5
Königsrainer, A.6
Maier, K.-P.7
Bischoff, S.C.8
Bergheim, I.9
-
34
-
-
35649007401
-
Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection
-
Dolganiuc, A.; Norkina, O.; Kodys, K.; Catalano, D.; Bakis, G.; Marshall, C.; Mandrekar, P.; Szabo, G. Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection. Gastroenterology 2007, 133, 1627-1636.
-
(2007)
Gastroenterology
, vol.133
, pp. 1627-1636
-
-
Dolganiuc, A.1
Norkina, O.2
Kodys, K.3
Catalano, D.4
Bakis, G.5
Marshall, C.6
Mandrekar, P.7
Szabo, G.8
-
35
-
-
34548272744
-
Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis
-
Rivera, C.A.; Adegboyega, P.; van Rooijen, N.; Tagalicud, A.; Allman, M.; Wallace, M. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J. Hepatol. 2007, 47, 571-579.
-
(2007)
J. Hepatol
, vol.47
, pp. 571-579
-
-
Rivera, C.A.1
Adegboyega, P.2
van Rooijen, N.3
Tagalicud, A.4
Allman, M.5
Wallace, M.6
-
36
-
-
35948958955
-
TLR4 enhances TGF-β signaling and hepatic fibrosis
-
Seki, E.; de Minicis, S.; Osterreicher, C.H.; Kluwe, J.; Osawa, Y.; Brenner, D.A.; Schwabe, R.F. TLR4 enhances TGF-β signaling and hepatic fibrosis. Nat. Med. 2007, 13, 1324-1332.
-
(2007)
Nat. Med
, vol.13
, pp. 1324-1332
-
-
Seki, E.1
de Minicis, S.2
Osterreicher, C.H.3
Kluwe, J.4
Osawa, Y.5
Brenner, D.A.6
Schwabe, R.F.7
-
37
-
-
14244252178
-
Bacterial translocation (BT) in cirrhosis
-
Wiest, R.; Garcia-Tsao, G. Bacterial translocation (BT) in cirrhosis. Hepatology 2005, 41, 422-433.
-
(2005)
Hepatology
, vol.41
, pp. 422-433
-
-
Wiest, R.1
Garcia-Tsao, G.2
-
38
-
-
0026078067
-
Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: Reevaluation with an improved chromogenic assay
-
Fukui, H.; Brauner, B.; Bode, J.C.; Bode, C. Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: Reevaluation with an improved chromogenic assay. J. Hepatol. 1991, 12, 162-169.
-
(1991)
J. Hepatol
, vol.12
, pp. 162-169
-
-
Fukui, H.1
Brauner, B.2
Bode, J.C.3
Bode, C.4
-
40
-
-
0000010865
-
Influence of neomycin and ingested endotoxin in the pathogenesis of choline deficiency cirrhosis in the adult rat
-
Broitman, S.A.; Gottlieb, L.S.; Zamcheck, N. Influence of neomycin and ingested endotoxin in the pathogenesis of choline deficiency cirrhosis in the adult rat. J. Exp. Med. 1964, 119, 633-642.
-
(1964)
J. Exp. Med
, vol.119
, pp. 633-642
-
-
Broitman, S.A.1
Gottlieb, L.S.2
Zamcheck, N.3
-
41
-
-
78651037890
-
The role of intestinal bacteria in the development of dietary cirrhosis in rats
-
Rutenburg, A.M.; Sonnenblick, E.; Koven, I.; Aprahamian, H.A.; Reiner, L.; Fine, J. The role of intestinal bacteria in the development of dietary cirrhosis in rats. J. Exp. Med. 1957, 106, 1-14.
-
(1957)
J. Exp. Med
, vol.106
, pp. 1-14
-
-
Rutenburg, A.M.1
Sonnenblick, E.2
Koven, I.3
Aprahamian, H.A.4
Reiner, L.5
Fine, J.6
-
42
-
-
84859812538
-
Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4
-
Dapito, D.H.; Mencin, A.; Gwak, G.Y.; Pradere, J.P.; Jang, M.K.; Mederacke, I.; Caviglia, J.M.; Khiabanian, H.; Adeyemi, A.; Bataller, R., et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 2012, 21, 504-516.
-
(2012)
Cancer Cell
, vol.21
, pp. 504-516
-
-
Dapito, D.H.1
Mencin, A.2
Gwak, G.Y.3
Pradere, J.P.4
Jang, M.K.5
Mederacke, I.6
Caviglia, J.M.7
Khiabanian, H.8
Adeyemi, A.9
Bataller, R.10
-
43
-
-
33845865825
-
Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
-
Yu, H.; Kortylewski, M.; Pardoll, D. Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment. Nat. Rev. Immunol. 2007, 7, 41-51.
-
(2007)
Nat. Rev. Immunol
, vol.7
, pp. 41-51
-
-
Yu, H.1
Kortylewski, M.2
Pardoll, D.3
-
44
-
-
84864657351
-
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
-
Pal, D.; Dasgupta, S.; Kundu, R.; Maitra, S.; Das, G.; Mukhopadhyay, S.; Ray, S.; Majumdar, S.S.; Bhattacharya, S. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat. Med. 2012, 18, 1279-1285.
-
(2012)
Nat. Med
, vol.18
, pp. 1279-1285
-
-
Pal, D.1
Dasgupta, S.2
Kundu, R.3
Maitra, S.4
Das, G.5
Mukhopadhyay, S.6
Ray, S.7
Majumdar, S.S.8
Bhattacharya, S.9
-
45
-
-
46149124353
-
Fetuin-A induces cytokine expression and suppresses adiponectin production
-
Hennige, A.M.; Staiger, H.; Wicke, C.; Machicao, F.; Fritsche, A.; Haring, H.U.; Stefan, N. Fetuin-A induces cytokine expression and suppresses adiponectin production. PLoS One 2008, 3, e1765.
-
(2008)
PLoS One
, vol.3
-
-
Hennige, A.M.1
Staiger, H.2
Wicke, C.3
Machicao, F.4
Fritsche, A.5
Haring, H.U.6
Stefan, N.7
-
46
-
-
78650859531
-
NF-κB and STAT3-Key players in liver inflammation and cancer
-
He, G.; Karin, M. NF-κB and STAT3-Key players in liver inflammation and cancer. Cell Res. 2011, 21, 159-168.
-
(2011)
Cell Res
, vol.21
, pp. 159-168
-
-
He, G.1
Karin, M.2
-
47
-
-
84864678390
-
High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction
-
Chalkiadaki, A.; Guarente, L. High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. Cell Metab. 2012, 16, 180-188.
-
(2012)
Cell Metab
, vol.16
, pp. 180-188
-
-
Chalkiadaki, A.1
Guarente, L.2
-
48
-
-
47749128879
-
Sirt1 protects against high-fat diet-induced metabolic damage
-
Pfluger, P.T.; Herranz, D.; Velasco-Miguel, S.; Serrano, M.; Tschop, M.H. Sirt1 protects against high-fat diet-induced metabolic damage. Proc. Natl. Acad. Sci. USA 2008, 105, 9793-9798.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 9793-9798
-
-
Pfluger, P.T.1
Herranz, D.2
Velasco-Miguel, S.3
Serrano, M.4
Tschop, M.H.5
-
49
-
-
77953257025
-
Aging and disease: Connections to sirtuins
-
Donmez, G.; Guarente, L. Aging and disease: Connections to sirtuins. Aging Cell 2010, 9, 285-290.
-
(2010)
Aging Cell
, vol.9
, pp. 285-290
-
-
Donmez, G.1
Guarente, L.2
-
50
-
-
78650758398
-
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
-
Herranz, D.; Munoz-Martin, M.; Canamero, M.; Mulero, F.; Martinez-Pastor, B.; Fernandez-Capetillo, O.; Serrano, M. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat. Commun. 2010, 1, 3.
-
(2010)
Nat. Commun
, vol.1
, pp. 3
-
-
Herranz, D.1
Munoz-Martin, M.2
Canamero, M.3
Mulero, F.4
Martinez-Pastor, B.5
Fernandez-Capetillo, O.6
Serrano, M.7
-
51
-
-
78649482634
-
SIRT1: Recent lessons from mouse models
-
Herranz, D.; Serrano, M. SIRT1: Recent lessons from mouse models. Nat. Rev. Cancer 2010, 10, 819-823.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 819-823
-
-
Herranz, D.1
Serrano, M.2
-
52
-
-
84858797950
-
Sirtuins as regulators of metabolism and healthspan
-
Houtkooper, R.H.; Pirinen, E.; Auwerx, J. Sirtuins as regulators of metabolism and healthspan. Nat. Rev. Mol. Cell Biol. 2012, 13, 225-238.
-
(2012)
Nat. Rev. Mol. Cell Biol
, vol.13
, pp. 225-238
-
-
Houtkooper, R.H.1
Pirinen, E.2
Auwerx, J.3
-
53
-
-
63449112017
-
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
-
Purushotham, A.; Schug, T.T.; Xu, Q.; Surapureddi, S.; Guo, X.; Li, X. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab. 2009, 9, 327-338.
-
(2009)
Cell Metab
, vol.9
, pp. 327-338
-
-
Purushotham, A.1
Schug, T.T.2
Xu, Q.3
Surapureddi, S.4
Guo, X.5
Li, X.6
-
54
-
-
33745166337
-
Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation
-
Kume, S.; Haneda, M.; Kanasaki, K.; Sugimoto, T.; Araki, S.; Isono, M.; Isshiki, K.; Uzu, T.; Kashiwagi, A.; Koya, D. Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation. Free Radic. Biol. Med. 2006, 40, 2175-2182.
-
(2006)
Free Radic. Biol. Med
, vol.40
, pp. 2175-2182
-
-
Kume, S.1
Haneda, M.2
Kanasaki, K.3
Sugimoto, T.4
Araki, S.5
Isono, M.6
Isshiki, K.7
Uzu, T.8
Kashiwagi, A.9
Koya, D.10
-
55
-
-
82255164629
-
SirT1 regulates adipose tissue inflammation
-
Gillum, M.P.; Kotas, M.E.; Erion, D.M.; Kursawe, R.; Chatterjee, P.; Nead, K.T.; Muise, E.S.; Hsiao, J.J.; Frederick, D.W.; Yonemitsu, S., et al. SirT1 regulates adipose tissue inflammation. Diabetes 2011, 60, 3235-3245.
-
(2011)
Diabetes
, vol.60
, pp. 3235-3245
-
-
Gillum, M.P.1
Kotas, M.E.2
Erion, D.M.3
Kursawe, R.4
Chatterjee, P.5
Nead, K.T.6
Muise, E.S.7
Hsiao, J.J.8
Frederick, D.W.9
Yonemitsu, S.10
-
56
-
-
77951174682
-
Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: Potential biochemical mechanisms
-
De Kreutzenberg, S.V.; Ceolotto, G.; Papparella, I.; Bortoluzzi, A.; Semplicini, A.; Dalla Man, C.; Cobelli, C.; Fadini, G.P.; Avogaro, A. Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: Potential biochemical mechanisms. Diabetes 2010, 59, 1006-1015.
-
(2010)
Diabetes
, vol.59
, pp. 1006-1015
-
-
de Kreutzenberg, S.V.1
Ceolotto, G.2
Papparella, I.3
Bortoluzzi, A.4
Semplicini, A.5
Dalla Man, C.6
Cobelli, C.7
Fadini, G.P.8
Avogaro, A.9
-
57
-
-
84879888338
-
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
-
Yoshimoto, S.; Loo, T.M.; Atarashi, K.; Kanda, H.; Sato, S.; Oyadomari, S.; Iwakura, Y.; Oshima, K.; Morita, H.; Hattori, M. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 2013, 499, 97-101.
-
(2013)
Nature
, vol.499
, pp. 97-101
-
-
Yoshimoto, S.1
Loo, T.M.2
Atarashi, K.3
Kanda, H.4
Sato, S.5
Oyadomari, S.6
Iwakura, Y.7
Oshima, K.8
Morita, H.9
Hattori, M.10
-
58
-
-
77955806634
-
JNK1 and IKKβ: Molecular links between obesity and metabolic dysfunction
-
Solinas, G.; Karin, M. JNK1 and IKKβ: Molecular links between obesity and metabolic dysfunction. FASEB J. 2010, 24, 2596-2611.
-
(2010)
FASEB J
, vol.24
, pp. 2596-2611
-
-
Solinas, G.1
Karin, M.2
-
59
-
-
77956029926
-
Interleukin-1β may mediate insulin resistance in liver-derived cells in response to adipocyte inflammation
-
Nov, O.; Kohl, A.; Lewis, E.C.; Bashan, N.; Dvir, I.; Ben-Shlomo, S.; Fishman, S.; Wueest, S.; Konrad, D.; Rudich, A. Interleukin-1β may mediate insulin resistance in liver-derived cells in response to adipocyte inflammation. Endocrinology 2010, 151, 4247-4256.
-
(2010)
Endocrinology
, vol.151
, pp. 4247-4256
-
-
Nov, O.1
Kohl, A.2
Lewis, E.C.3
Bashan, N.4
Dvir, I.5
Ben-Shlomo, S.6
Fishman, S.7
Wueest, S.8
Konrad, D.9
Rudich, A.10
-
60
-
-
0042330251
-
Minireview: The adipocyte-At the crossroads of energy homeostasis, inflammation, and atherosclerosis
-
Rajala, M.W.; Scherer, P.E. Minireview: The adipocyte-At the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 2003, 144, 3765-3773.
-
(2003)
Endocrinology
, vol.144
, pp. 3765-3773
-
-
Rajala, M.W.1
Scherer, P.E.2
-
61
-
-
0013607356
-
Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells
-
Patton, J.S.; Shepard, H.M.; Wilking, H.; Lewis, G.; Aggarwal, B.B.; Eessalu, T.E.; Gavin, L.A.; Grunfeld, C. Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells. Proc. Natl. Acad. Sci. USA 1986, 83, 8313-8317.
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 8313-8317
-
-
Patton, J.S.1
Shepard, H.M.2
Wilking, H.3
Lewis, G.4
Aggarwal, B.B.5
Eessalu, T.E.6
Gavin, L.A.7
Grunfeld, C.8
-
62
-
-
0025260531
-
Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors
-
Wanless, I.R.; Lentz, J.S. Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors. Hepatology 1990, 12, 1106-1110.
-
(1990)
Hepatology
, vol.12
, pp. 1106-1110
-
-
Wanless, I.R.1
Lentz, J.S.2
-
63
-
-
33646690516
-
Association between human fetuin-A and the metabolic syndrome: Data from the heart and soul study
-
Ix, J.H.; Shlipak, M.G.; Brandenburg, V.M.; Ali, S.; Ketteler, M.; Whooley, M.A. Association between human fetuin-A and the metabolic syndrome: Data from the heart and soul study. Circulation 2006, 113, 1760-1767.
-
(2006)
Circulation
, vol.113
, pp. 1760-1767
-
-
Ix, J.H.1
Shlipak, M.G.2
Brandenburg, V.M.3
Ali, S.4
Ketteler, M.5
Whooley, M.A.6
-
64
-
-
84857926081
-
Fetuin A in nonalcoholic fatty liver disease: In vivo and in vitro studies
-
Haukeland, J.W.; Dahl, T.B.; Yndestad, A.; Gladhaug, I.P.; Loberg, E.M.; Haaland, T.; Konopski, Z.; Wium, C.; Aasheim, E.T.; Johansen, O.E., et al. Fetuin A in nonalcoholic fatty liver disease: In vivo and in vitro studies. Eur. J. Endocrinol. 2012, 166, 503-510.
-
(2012)
Eur. J. Endocrinol
, vol.166
, pp. 503-510
-
-
Haukeland, J.W.1
Dahl, T.B.2
Yndestad, A.3
Gladhaug, I.P.4
Loberg, E.M.5
Haaland, T.6
Konopski, Z.7
Wium, C.8
Aasheim, E.T.9
Johansen, O.E.10
-
65
-
-
35548943962
-
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity
-
Solinas, G.; Vilcu, C.; Neels, J.G.; Bandyopadhyay, G.K.; Luo, J.L.; Naugler, W.; Grivennikov, S.; Wynshaw-Boris, A.; Scadeng, M.; Olefsky, J.M., et al. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 2007, 6, 386-397.
-
(2007)
Cell Metab
, vol.6
, pp. 386-397
-
-
Solinas, G.1
Vilcu, C.2
Neels, J.G.3
Bandyopadhyay, G.K.4
Luo, J.L.5
Naugler, W.6
Grivennikov, S.7
Wynshaw-Boris, A.8
Scadeng, M.9
Olefsky, J.M.10
-
66
-
-
84864198388
-
A liver full of JNK: Signaling in regulation of cell function and disease pathogenesis, and clinical approaches
-
Seki, E.; Brenner, D.A.; Karin, M. A liver full of JNK: Signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology 2012, 143, 307-320.
-
(2012)
Gastroenterology
, vol.143
, pp. 307-320
-
-
Seki, E.1
Brenner, D.A.2
Karin, M.3
-
67
-
-
67749117934
-
Signal integration by JNK and p38 MAPK pathways in cancer development
-
Wagner, E.F.; Nebreda, Á.R. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat. Rev. Cancer 2009, 9, 537-549.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 537-549
-
-
Wagner, E.F.1
Nebreda, A.R.2
-
68
-
-
80053554640
-
Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation
-
Holzer, R.G.; Park, E.J.; Li, N.; Tran, H.; Chen, M.; Choi, C.; Solinas, G.; Karin, M. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 2011, 147, 173-184.
-
(2011)
Cell
, vol.147
, pp. 173-184
-
-
Holzer, R.G.1
Park, E.J.2
Li, N.3
Tran, H.4
Chen, M.5
Choi, C.6
Solinas, G.7
Karin, M.8
-
69
-
-
0030668555
-
Interleukin-6-dependent and -independent regulation of the human C-reactive protein gene
-
Weinhold, B.; Ruther, U. Interleukin-6-dependent and -independent regulation of the human C-reactive protein gene. Biochem. J. 1997, 327, 425-429.
-
(1997)
Biochem. J
, vol.327
, pp. 425-429
-
-
Weinhold, B.1
Ruther, U.2
-
70
-
-
0025228036
-
Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6
-
Castell, J.V.; Gomez-Lechon, M.J.; David, M.; Fabra, R.; Trullenque, R.; Heinrich, P.C. Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6. Hepatology 1990, 12, 1179-1186.
-
(1990)
Hepatology
, vol.12
, pp. 1179-1186
-
-
Castell, J.V.1
Gomez-Lechon, M.J.2
David, M.3
Fabra, R.4
Trullenque, R.5
Heinrich, P.C.6
-
71
-
-
0033537013
-
Elevated C-reactive protein levels in overweight and obese adults
-
Visser, M.; Bouter, L.M.; McQuillan, G.M.; Wener, M.H.; Harris, T.B. Elevated C-reactive protein levels in overweight and obese adults. JAMA 1999, 282, 2131-2135.
-
(1999)
JAMA
, vol.282
, pp. 2131-2135
-
-
Visser, M.1
Bouter, L.M.2
McQuillan, G.M.3
Wener, M.H.4
Harris, T.B.5
-
72
-
-
0030756346
-
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
-
Uysal, K.T.; Wiesbrock, S.M.; Marino, M.W.; Hotamisligil, G.S. Protection from obesity-induced insulin resistance in mice lacking TNF-α function. Nature 1997, 389, 610-614.
-
(1997)
Nature
, vol.389
, pp. 610-614
-
-
Uysal, K.T.1
Wiesbrock, S.M.2
Marino, M.W.3
Hotamisligil, G.S.4
-
73
-
-
76249087046
-
Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis
-
Inokuchi, S.; Aoyama, T.; Miura, K.; Osterreicher, C.H.; Kodama, Y.; Miyai, K.; Akira, S.; Brenner, D.A.; Seki, E. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc. Natl. Acad. Sci. USA 2010, 107, 844-849.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 844-849
-
-
Inokuchi, S.1
Aoyama, T.2
Miura, K.3
Osterreicher, C.H.4
Kodama, Y.5
Miyai, K.6
Akira, S.7
Brenner, D.A.8
Seki, E.9
-
74
-
-
0031916439
-
The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes
-
Auer, K.L.; Contessa, J.; Brenz-Verca, S.; Pirola, L.; Rusconi, S.; Cooper, G.; Abo, A.; Wymann, M.P.; Davis, R.J.; Birrer, M. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Mol. Biol. Cell 1998, 9, 561-573.
-
(1998)
Mol. Biol. Cell
, vol.9
, pp. 561-573
-
-
Auer, K.L.1
Contessa, J.2
Brenz-Verca, S.3
Pirola, L.4
Rusconi, S.5
Cooper, G.6
Abo, A.7
Wymann, M.P.8
Davis, R.J.9
Birrer, M.10
-
75
-
-
78650841188
-
Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J- +Leprdb/+Leprdb mice
-
Shimizu, M.; Sakai, H.; Shirakami, Y.; Iwasa, J.; Yasuda, Y.; Kubota, M.; Takai, K.; Tsurumi, H.; Tanaka, T.; Moriwaki, H. Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J- +Leprdb/+Leprdb mice. Cancer Prev. Res. 2011, 4, 128-136.
-
(2011)
Cancer Prev. Res
, vol.4
, pp. 128-136
-
-
Shimizu, M.1
Sakai, H.2
Shirakami, Y.3
Iwasa, J.4
Yasuda, Y.5
Kubota, M.6
Takai, K.7
Tsurumi, H.8
Tanaka, T.9
Moriwaki, H.10
-
76
-
-
45349094887
-
Chemoprevention of liver carcinogenesis with retinoids: Basic and clinical aspects
-
Moriwaki, H.; Shimizu, M.; Okuno, M.; Nishiwaki-Matsushima, R. Chemoprevention of liver carcinogenesis with retinoids: Basic and clinical aspects. Hepatol. Res. 2007, 37, S299-S302.
-
(2007)
Hepatol. Res
, vol.37
-
-
Moriwaki, H.1
Shimizu, M.2
Okuno, M.3
Nishiwaki-Matsushima, R.4
-
77
-
-
0035886844
-
Phosphorylation of retinoid X receptor α at serine 260 impairs its metabolism and function in human hepatocellular carcinoma
-
Matsushima-Nishiwaki, R.; Okuno, M.; Adachi, S.; Sano, T.; Akita, K.; Moriwaki, H.; Friedman, S.L.; Kojima, S. Phosphorylation of retinoid X receptor α at serine 260 impairs its metabolism and function in human hepatocellular carcinoma. Cancer Res. 2001, 61, 7675-7682.
-
(2001)
Cancer Res
, vol.61
, pp. 7675-7682
-
-
Matsushima-Nishiwaki, R.1
Okuno, M.2
Adachi, S.3
Sano, T.4
Akita, K.5
Moriwaki, H.6
Friedman, S.L.7
Kojima, S.8
-
78
-
-
84857640868
-
The insulin and insulin-like growth factor receptor family in neoplasia: An update
-
Pollak, M. The insulin and insulin-like growth factor receptor family in neoplasia: An update. Nat. Rev. Cancer 2012, 12, 159-169.
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 159-169
-
-
Pollak, M.1
-
79
-
-
56749184290
-
Insulin and insulin-like growth factor signalling in neoplasia
-
Pollak, M. Insulin and insulin-like growth factor signalling in neoplasia. Nat. Rev. Cancer 2008, 8, 915-928.
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 915-928
-
-
Pollak, M.1
-
80
-
-
79551495819
-
A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1, -2 and-3 in the European Prospective Investigation into Cancer and Nutrition (EPIC)
-
Crowe, F.L.; Key, T.J.; Allen, N.E.; Appleby, P.N.; Overvad, K.; Grønbæk, H.; Tjønneland, A.; Halkjær, J.; Dossus, L.; Boeing, H. A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1, -2 and-3 in the European Prospective Investigation into Cancer and Nutrition (EPIC). Ann. Hum. Biol. 2011, 38, 194-202.
-
(2011)
Ann. Hum. Biol
, vol.38
, pp. 194-202
-
-
Crowe, F.L.1
Key, T.J.2
Allen, N.E.3
Appleby, P.N.4
Overvad, K.5
Grønbæk, H.6
Tjønneland, A.7
Halkjær, J.8
Dossus, L.9
Boeing, H.10
-
81
-
-
84880953279
-
Non-alcoholic steatohepatitis: The role of oxidized low-density lipoproteins
-
Walenbergh, S.M.; Koek, G.H.; Bieghs, V.; Shiri-Sverdlov, R. Non-alcoholic steatohepatitis: The role of oxidized low-density lipoproteins. J. Hepatol. 2013, 58, 801-810.
-
(2013)
J. Hepatol
, vol.58
, pp. 801-810
-
-
Walenbergh, S.M.1
Koek, G.H.2
Bieghs, V.3
Shiri-Sverdlov, R.4
-
82
-
-
84859354773
-
Effect of dietary advanced glycation end products on mouse liver
-
Patel, R.; Baker, S.S.; Liu, W.; Desai, S.; Alkhouri, R.; Kozielski, R.; Mastrandrea, L.; Sarfraz, A.; Cai, W.; Vlassara, H. Effect of dietary advanced glycation end products on mouse liver. PLoS One 2012, 7, e35143.
-
(2012)
PLoS One
, vol.7
-
-
Patel, R.1
Baker, S.S.2
Liu, W.3
Desai, S.4
Alkhouri, R.5
Kozielski, R.6
Mastrandrea, L.7
Sarfraz, A.8
Cai, W.9
Vlassara, H.10
-
83
-
-
0029819955
-
Does free fatty acid infusion impair insulin action also through an increase in oxidative stress?
-
Paolisso, G.; Gambardella, A.; Tagliamonte, M.; Saccomanno, F.; Salvatore, T.; Gualdiero, P.; DOnofrio, M.; Howard, B. Does free fatty acid infusion impair insulin action also through an increase in oxidative stress? J. Clin. Endocrinol. Metab. 1996, 81, 4244-4248.
-
(1996)
J. Clin. Endocrinol. Metab
, vol.81
, pp. 4244-4248
-
-
Paolisso, G.1
Gambardella, A.2
Tagliamonte, M.3
Saccomanno, F.4
Salvatore, T.5
Gualdiero, P.6
Donofrio, M.7
Howard, B.8
-
84
-
-
0346037268
-
Scavenger receptors class AI/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages
-
Kunjathoor, V.V.; Febbraio, M.; Podrez, E.A.; Moore, K.J.; Andersson, L.; Koehn, S.; Rhee, J.S.; Silverstein, R.; Hoff, H.F.; Freeman, M.W. Scavenger receptors class AI/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J. Biol. Chem. 2002, 277, 49982-49988.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 49982-49988
-
-
Kunjathoor, V.V.1
Febbraio, M.2
Podrez, E.A.3
Moore, K.J.4
Andersson, L.5
Koehn, S.6
Rhee, J.S.7
Silverstein, R.8
Hoff, H.F.9
Freeman, M.W.10
-
85
-
-
84862669638
-
Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis
-
Leroux, A.; Ferrere, G.; Godie, V.; Cailleux, F.; Renoud, M.-L.; Gaudin, F.; Naveau, S.; Prévot, S.; Makhzami, S.; Perlemuter, G. Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. J. Hepatol. 2012, 57, 141-149.
-
(2012)
J. Hepatol
, vol.57
, pp. 141-149
-
-
Leroux, A.1
Ferrere, G.2
Godie, V.3
Cailleux, F.4
Renoud, M.-L.5
Gaudin, F.6
Naveau, S.7
Prévot, S.8
Makhzami, S.9
Perlemuter, G.10
-
86
-
-
84859081972
-
Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells
-
Bieghs, V.; Verheyen, F.; van Gorp, P.J.; Hendrikx, T.; Wouters, K.; Lütjohann, D.; Gijbels, M.J.; Febbraio, M.; Binder, C.J.; Hofker, M.H. Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells. PLoS One 2012, 7, e34378.
-
(2012)
PLoS One
, vol.7
-
-
Bieghs, V.1
Verheyen, F.2
van Gorp, P.J.3
Hendrikx, T.4
Wouters, K.5
Lütjohann, D.6
Gijbels, M.J.7
Febbraio, M.8
Binder, C.J.9
Hofker, M.H.10
-
87
-
-
84865348839
-
Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation
-
Jiang, Y.; Wang, M.; Huang, K.; Zhang, Z.; Shao, N.; Zhang, Y.; Wang, W.; Wang, S. Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation. Biochem. Biophys. Res. Commun. 2012, 425, 121-126.
-
(2012)
Biochem. Biophys. Res. Commun
, vol.425
, pp. 121-126
-
-
Jiang, Y.1
Wang, M.2
Huang, K.3
Zhang, Z.4
Shao, N.5
Zhang, Y.6
Wang, W.7
Wang, S.8
-
88
-
-
33845573580
-
Lipopolysaccharide-induced gene expression in murine macrophages is enhanced by prior exposure to oxLDL
-
Groeneweg, M.; Kanters, E.; Vergouwe, M.N.; Duerink, H.; Kraal, G.; Hofker, M.H.; de Winther, M.P. Lipopolysaccharide-induced gene expression in murine macrophages is enhanced by prior exposure to oxLDL. J. Lipid Res. 2006, 47, 2259-2267.
-
(2006)
J. Lipid Res
, vol.47
, pp. 2259-2267
-
-
Groeneweg, M.1
Kanters, E.2
Vergouwe, M.N.3
Duerink, H.4
Kraal, G.5
Hofker, M.H.6
de Winther, M.P.7
-
89
-
-
0027233746
-
Genetic control of inflammatory gene induction and NF-κB-like transcription factor activation in response to an atherogenic diet in mice
-
Liao, F.; Andalibi, A. Genetic control of inflammatory gene induction and NF-κB-like transcription factor activation in response to an atherogenic diet in mice. J. Clin. Investig. 1993, 91, 2572-2579.
-
(1993)
J. Clin. Investig
, vol.91
, pp. 2572-2579
-
-
Liao, F.1
Andalibi, A.2
-
90
-
-
84865551517
-
Specific immunization strategies against oxidized low-density lipoprotein: A novel way to reduce nonalcoholic steatohepatitis in mice
-
Bieghs, V.; van Gorp, P.J.; Walenbergh, S.; Gijbels, M.J.; Verheyen, F.; Buurman, W.A.; Briles, D.E.; Hofker, M.H.; Binder, C.J.; Shiri-Sverdlov, R. Specific immunization strategies against oxidized low-density lipoprotein: A novel way to reduce nonalcoholic steatohepatitis in mice. Hepatology 2012, 56, 894-903.
-
(2012)
Hepatology
, vol.56
, pp. 894-903
-
-
Bieghs, V.1
van Gorp, P.J.2
Walenbergh, S.3
Gijbels, M.J.4
Verheyen, F.5
Buurman, W.A.6
Briles, D.E.7
Hofker, M.H.8
Binder, C.J.9
Shiri-Sverdlov, R.10
-
91
-
-
77952717393
-
Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice
-
Bieghs, V.; Wouters, K.; van Gorp, P.J.; Gijbels, M.J.; de Winther, M.P.; Binder, C.J.; Lütjohann, D.; Febbraio, M.; Moore, K.J.; van Bilsen, M. Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice. Gastroenterology 2010, 138, 2477-2486. e3.
-
(2010)
Gastroenterology
, vol.138
, pp. 2477-2486
-
-
Bieghs, V.1
Wouters, K.2
van Gorp, P.J.3
Gijbels, M.J.4
de Winther, M.P.5
Binder, C.J.6
Lütjohann, D.7
Febbraio, M.8
Moore, K.J.9
van Bilsen, M.10
-
92
-
-
84856449557
-
A novel murine model for non-alcoholic steatohepatitis developed by combination of a high-fat diet and oxidized low-density lipoprotein
-
Yimin, H.F.; Matsuoka, S.; Sakurai, T.; Kohanawa, M.; Zhao, S.; Kuge, Y.; Tamaki, N.; Chiba, H. A novel murine model for non-alcoholic steatohepatitis developed by combination of a high-fat diet and oxidized low-density lipoprotein. Lab. Investig. 2011, 92, 265-281.
-
(2011)
Lab. Investig
, vol.92
, pp. 265-281
-
-
Yimin, H.F.1
Matsuoka, S.2
Sakurai, T.3
Kohanawa, M.4
Zhao, S.5
Kuge, Y.6
Tamaki, N.7
Chiba, H.8
-
93
-
-
84880683621
-
Omega-3 fatty acids, hepatic lipid metabolism, and nonalcoholic fatty liver disease
-
Scorletti, E.; Byrne, C.D. Omega-3 fatty acids, hepatic lipid metabolism, and nonalcoholic fatty liver disease. Annu. Rev. Nutr. 2013, 33, 231-248.
-
(2013)
Annu. Rev. Nutr
, vol.33
, pp. 231-248
-
-
Scorletti, E.1
Byrne, C.D.2
-
94
-
-
84858701950
-
The interaction of hepatic lipid and glucose metabolism in liver diseases
-
Bechmann, L.P.; Hannivoort, R.A.; Gerken, G.; Hotamisligil, G.S.; Trauner, M.; Canbay, A. The interaction of hepatic lipid and glucose metabolism in liver diseases. J. Hepatol. 2012, 56, 952-964.
-
(2012)
J. Hepatol
, vol.56
, pp. 952-964
-
-
Bechmann, L.P.1
Hannivoort, R.A.2
Gerken, G.3
Hotamisligil, G.S.4
Trauner, M.5
Canbay, A.6
-
95
-
-
78651081729
-
Effects of farnesoid X receptor on the expression of the fatty acid synthetase and hepatic lipase
-
Shen, L.-L.; Liu, H.; Gan, L.; Lu, L.; Zhang, Q.; Li, L.; He, F.; Jiang, Y. Effects of farnesoid X receptor on the expression of the fatty acid synthetase and hepatic lipase. Mol. Biol. Rep. 2011, 38, 553-559.
-
(2011)
Mol. Biol. Rep
, vol.38
, pp. 553-559
-
-
Shen, L.-L.1
Liu, H.2
Gan, L.3
Lu, L.4
Zhang, Q.5
Li, L.6
He, F.7
Jiang, Y.8
-
96
-
-
22544473888
-
A role for PPARα in the control of SREBP activity and lipid synthesis in the liver
-
Knight, B.; Hebbachi, A.; Hauton, D.; Brown, A.; Wiggins, D.; Patel, D.; Gibbons, G. A role for PPARα in the control of SREBP activity and lipid synthesis in the liver. Biochem. J. 2005, 389, 413-421.
-
(2005)
Biochem. J
, vol.389
, pp. 413-421
-
-
Knight, B.1
Hebbachi, A.2
Hauton, D.3
Brown, A.4
Wiggins, D.5
Patel, D.6
Gibbons, G.7
-
97
-
-
19444383246
-
PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes
-
Schadinger, S.E.; Bucher, N.L.; Schreiber, B.M.; Farmer, S.R. PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes. Am. J. Physiol. Endocrinol. Metab. 2005, 288, E1195-E1205.
-
(2005)
Am. J. Physiol. Endocrinol. Metab
, vol.288
-
-
Schadinger, S.E.1
Bucher, N.L.2
Schreiber, B.M.3
Farmer, S.R.4
-
98
-
-
14544289119
-
Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): Two key regulators of glucose metabolism and lipid synthesis in liver
-
Dentin, R.; Girard, J.; Postic, C. Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): Two key regulators of glucose metabolism and lipid synthesis in liver. Biochimie 2005, 87, 81-86.
-
(2005)
Biochimie
, vol.87
, pp. 81-86
-
-
Dentin, R.1
Girard, J.2
Postic, C.3
-
99
-
-
18244382304
-
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
-
Donnelly, K.L.; Smith, C.I.; Schwarzenberg, S.J.; Jessurun, J.; Boldt, M.D.; Parks, E.J. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Investig. 2005, 115, 1343-1351.
-
(2005)
J. Clin. Investig
, vol.115
, pp. 1343-1351
-
-
Donnelly, K.L.1
Smith, C.I.2
Schwarzenberg, S.J.3
Jessurun, J.4
Boldt, M.D.5
Parks, E.J.6
-
100
-
-
79952312698
-
Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma
-
Calvisi, D.F.; Wang, C.; Ho, C.; Ladu, S.; Lee, S.A.; Mattu, S.; Destefanis, G.; Delogu, S.; Zimmermann, A.; Ericsson, J., et al. Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Gastroenterology 2011, 140, 1071-1083.
-
(2011)
Gastroenterology
, vol.140
, pp. 1071-1083
-
-
Calvisi, D.F.1
Wang, C.2
Ho, C.3
Ladu, S.4
Lee, S.A.5
Mattu, S.6
Destefanis, G.7
Delogu, S.8
Zimmermann, A.9
Ericsson, J.10
-
101
-
-
84858859318
-
High fat diet induced hepatic steatosis and insulin resistance: Role of dysregulated ceramide metabolism
-
Longato, L.; Tong, M.; Wands, J.R.; de la Monte, S.M. High fat diet induced hepatic steatosis and insulin resistance: Role of dysregulated ceramide metabolism. Hepatol. Res. 2012, 42, 412-427.
-
(2012)
Hepatol. Res
, vol.42
, pp. 412-427
-
-
Longato, L.1
Tong, M.2
Wands, J.R.3
de la Monte, S.M.4
-
102
-
-
84864292975
-
Role of ceramides in nonalcoholic fatty liver disease
-
Pagadala, M.; Kasumov, T.; McCullough, A.J.; Zein, N.N.; Kirwan, J.P. Role of ceramides in nonalcoholic fatty liver disease. Trends Endocrinol. Metab. 2012, 23, 365-371.
-
(2012)
Trends Endocrinol. Metab
, vol.23
, pp. 365-371
-
-
Pagadala, M.1
Kasumov, T.2
McCullough, A.J.3
Zein, N.N.4
Kirwan, J.P.5
-
103
-
-
79960737448
-
Weight loss amelioration of non-alcoholic steatohepatitis linked to shifts in hepatic ceramide expression and serum ceramide levels
-
Promrat, K.; Longato, L.; Wands, J.R.; de la Monte, S.M. Weight loss amelioration of non-alcoholic steatohepatitis linked to shifts in hepatic ceramide expression and serum ceramide levels. Hepatol. Res. 2011, 41, 754-762.
-
(2011)
Hepatol. Res
, vol.41
, pp. 754-762
-
-
Promrat, K.1
Longato, L.2
Wands, J.R.3
de la Monte, S.M.4
-
104
-
-
77954427437
-
High fat diet induces ceramide and sphingomyelin formation in rat's liver nuclei
-
Chocian, G.; Chabowski, A.; Zendzian-Piotrowska, M.; Harasim, E.; Łukaszuk, B.; Górski, J. High fat diet induces ceramide and sphingomyelin formation in rat's liver nuclei. Mol. Cell. Biochem. 2010, 340, 125-131.
-
(2010)
Mol. Cell. Biochem
, vol.340
, pp. 125-131
-
-
Chocian, G.1
Chabowski, A.2
Zendzian-Piotrowska, M.3
Harasim, E.4
łukaszuk, B.5
Górski, J.6
-
105
-
-
33847332202
-
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
-
Holland, W.L.; Brozinick, J.T.; Wang, L.-P.; Hawkins, E.D.; Sargent, K.M.; Liu, Y.; Narra, K.; Hoehn, K.L.; Knotts, T.A.; Siesky, A. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 2007, 5, 167-179.
-
(2007)
Cell Metab
, vol.5
, pp. 167-179
-
-
Holland, W.L.1
Brozinick, J.T.2
Wang, L.-P.3
Hawkins, E.D.4
Sargent, K.M.5
Liu, Y.6
Narra, K.7
Hoehn, K.L.8
Knotts, T.A.9
Siesky, A.10
-
106
-
-
79955487247
-
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-Induced ceramide biosynthesis in mice
-
Holland, W.L.; Bikman, B.T.; Wang, L.-P.; Yuguang, G.; Sargent, K.M.; Bulchand, S.; Knotts, T.A.; Shui, G.; Clegg, D.J.; Wenk, M.R. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-Induced ceramide biosynthesis in mice. J. Clin. Investig. 2011, 121, 1858-1870.
-
(2011)
J. Clin. Investig
, vol.121
, pp. 1858-1870
-
-
Holland, W.L.1
Bikman, B.T.2
Wang, L.-P.3
Yuguang, G.4
Sargent, K.M.5
Bulchand, S.6
Knotts, T.A.7
Shui, G.8
Clegg, D.J.9
Wenk, M.R.10
-
107
-
-
79551555431
-
Endotoxin activates de novo sphingolipid biosynthesis via nuclear factor κB-mediated upregulation of Sptlc2
-
Chang, Z.-Q.; Lee, S.-Y.; Kim, H.-J.; Kim, J.R.; Kim, S.-J.; Hong, I.-K.; Oh, B.-C.; Choi, C.-S.; Goldberg, I.J.; Park, T.-S. Endotoxin activates de novo sphingolipid biosynthesis via nuclear factor κB-mediated upregulation of Sptlc2. Prostaglandins Other Lipid Mediat. 2011, 94, 44-52.
-
(2011)
Prostaglandins Other Lipid Mediat
, vol.94
, pp. 44-52
-
-
Chang, Z.-Q.1
Lee, S.-Y.2
Kim, H.-J.3
Kim, J.R.4
Kim, S.-J.5
Hong, I.-K.6
Oh, B.-C.7
Choi, C.-S.8
Goldberg, I.J.9
Park, T.-S.10
-
108
-
-
33646127797
-
nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis
-
Levy, M.; Castillo, S.S.; Goldkorn, T. nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis. Biochem. Biophys. Res. Commun. 2006, 344, 900-905.
-
(2006)
Biochem. Biophys. Res. Commun
, vol.344
, pp. 900-905
-
-
Levy, M.1
Castillo, S.S.2
Goldkorn, T.3
-
109
-
-
77953811195
-
Ceramide channels and their role in mitochondria-mediated apoptosis
-
Colombini, M. Ceramide channels and their role in mitochondria-mediated apoptosis. Biochim. Biophys. Acta 2010, 1797, 1239-1244.
-
(2010)
Biochim. Biophys. Acta
, vol.1797
, pp. 1239-1244
-
-
Colombini, M.1
-
110
-
-
45149106053
-
Sphingolipids, insulin resistance, and metabolic disease: New insights from in vivo manipulation of sphingolipid metabolism
-
Holland, W.L.; Summers, S.A. Sphingolipids, insulin resistance, and metabolic disease: New insights from in vivo manipulation of sphingolipid metabolism. Endocr. Rev. 2008, 29, 381-402.
-
(2008)
Endocr. Rev
, vol.29
, pp. 381-402
-
-
Holland, W.L.1
Summers, S.A.2
-
111
-
-
42949105726
-
Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins
-
Stiban, J.; Caputo, L.; Colombini, M. Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins. J. Lipid Res. 2008, 49, 625-634.
-
(2008)
J. Lipid Res
, vol.49
, pp. 625-634
-
-
Stiban, J.1
Caputo, L.2
Colombini, M.3
-
112
-
-
84856111924
-
The unfolded protein response: Controlling cell fate decisions under ER stress and beyond
-
Hetz, C. The unfolded protein response: Controlling cell fate decisions under ER stress and beyond. Nat. Rev. Mol. Cell Biol. 2012, 13, 89-102.
-
(2012)
Nat. Rev. Mol. Cell Biol
, vol.13
, pp. 89-102
-
-
Hetz, C.1
-
113
-
-
84860483727
-
The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling
-
Fu, S.; Watkins, S.M.; Hotamisligil, G.S. The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling. Cell Metab. 2012, 15, 623-634.
-
(2012)
Cell Metab
, vol.15
, pp. 623-634
-
-
Fu, S.1
Watkins, S.M.2
Hotamisligil, G.S.3
-
114
-
-
79952708723
-
Endoplasmic reticulum stress in liver disease
-
Malhi, H.; Kaufman, R.J. Endoplasmic reticulum stress in liver disease. J. Hepatol. 2011, 54, 795-809.
-
(2011)
J. Hepatol
, vol.54
, pp. 795-809
-
-
Malhi, H.1
Kaufman, R.J.2
-
115
-
-
0038216621
-
Activation of the ATF6, XBP1 and GRP78 genes in human hepatocellular carcinoma: A possible involvement of the ER stress pathway in hepatocarcinogenesis
-
Shuda, M.; Kondoh, N.; Imazeki, N.; Tanaka, K.; Okada, T.; Mori, K.; Hada, A.; Arai, M.; Wakatsuki, T.; Matsubara, O. Activation of the ATF6, XBP1 and GRP78 genes in human hepatocellular carcinoma: A possible involvement of the ER stress pathway in hepatocarcinogenesis. J. Hepatol. 2003, 38, 605-614.
-
(2003)
J. Hepatol
, vol.38
, pp. 605-614
-
-
Shuda, M.1
Kondoh, N.2
Imazeki, N.3
Tanaka, K.4
Okada, T.5
Mori, K.6
Hada, A.7
Arai, M.8
Wakatsuki, T.9
Matsubara, O.10
-
116
-
-
84864003561
-
PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation
-
Bobrovnikova-Marjon, E.; Pytel, D.; Riese, M.J.; Vaites, L.P.; Singh, N.; Koretzky, G.A.; Witze, E.S.; Diehl, J.A. PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation. Mol. Cell. Biol. 2012, 32, 2268-2278.
-
(2012)
Mol. Cell. Biol
, vol.32
, pp. 2268-2278
-
-
Bobrovnikova-Marjon, E.1
Pytel, D.2
Riese, M.J.3
Vaites, L.P.4
Singh, N.5
Koretzky, G.A.6
Witze, E.S.7
Diehl, J.A.8
-
117
-
-
60149106099
-
PERK-dependent regulation of IAP translation during ER stress
-
Hamanaka, R.B.; Bobrovnikova-Marjon, E.; Ji, X.; Liebhaber, S.A.; Diehl, J.A. PERK-dependent regulation of IAP translation during ER stress. Oncogene 2008, 28, 910-920.
-
(2008)
Oncogene
, vol.28
, pp. 910-920
-
-
Hamanaka, R.B.1
Bobrovnikova-Marjon, E.2
Ji, X.3
Liebhaber, S.A.4
Diehl, J.A.5
-
118
-
-
34548511321
-
A novel function of eIF2α kinases as inducers of the phosphoinositide-3 kinase signaling pathway
-
Kazemi, S.; Mounir, Z.; Baltzis, D.; Raven, J.F.; Wang, S.; Krishnamoorthy, J.-L.; Pluquet, O.; Pelletier, J.; Koromilas, A.E. A novel function of eIF2α kinases as inducers of the phosphoinositide-3 kinase signaling pathway. Mol. Biol. Cell 2007, 18, 3635-3644.
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 3635-3644
-
-
Kazemi, S.1
Mounir, Z.2
Baltzis, D.3
Raven, J.F.4
Wang, S.5
Krishnamoorthy, J.-L.6
Pluquet, O.7
Pelletier, J.8
Koromilas, A.E.9
-
119
-
-
66449137379
-
GRP78 expression inhibits insulin and ER stress-Induced SREBP-1c activation and reduces hepatic steatosis in mice
-
Kammoun, H.L.; Chabanon, H.; Hainault, I.; Luquet, S.; Magnan, C.; Koike, T.; Ferré, P.; Foufelle, F. GRP78 expression inhibits insulin and ER stress-Induced SREBP-1c activation and reduces hepatic steatosis in mice. J. Clin. Investig. 2009, 119, 1201-1215.
-
(2009)
J. Clin. Investig
, vol.119
, pp. 1201-1215
-
-
Kammoun, H.L.1
Chabanon, H.2
Hainault, I.3
Luquet, S.4
Magnan, C.5
Koike, T.6
Ferré, P.7
Foufelle, F.8
-
120
-
-
0031043030
-
The mitochondrial carnitine palmitoyltransferase system-From concept to molecular analysis
-
McGarry, J.D.; Brown, N.F. The mitochondrial carnitine palmitoyltransferase system-From concept to molecular analysis. Eur. J. Biochem. 1997, 244, 1-14.
-
(1997)
Eur. J. Biochem
, vol.244
, pp. 1-14
-
-
McGarry, J.D.1
Brown, N.F.2
-
121
-
-
66949149506
-
Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids1
-
Akkaoui, M.; Cohen, I.; Esnous, C.; Lenoir, V.; Sournac, M.; Girard, J.; Prip-Buus, C. Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids1. Biochem. J. 2009, 420, 429-438.
-
(2009)
Biochem. J
, vol.420
, pp. 429-438
-
-
Akkaoui, M.1
Cohen, I.2
Esnous, C.3
Lenoir, V.4
Sournac, M.5
Girard, J.6
Prip-Buus, C.7
-
122
-
-
0035658444
-
Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal β-oxidation, PPARα, and steatohepatitis
-
Reddy, J.K. Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal β-oxidation, PPARα, and steatohepatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 2001, 281, G1333-G1339.
-
(2001)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.281
-
-
Reddy, J.K.1
-
123
-
-
84872406355
-
CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease
-
Leung, T.M.; Nieto, N. CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease. J. Hepatol. 2013, 58, 395-398.
-
(2013)
J. Hepatol
, vol.58
, pp. 395-398
-
-
Leung, T.M.1
Nieto, N.2
-
124
-
-
80054859494
-
Increased expression of cytochrome P450. 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role
-
Aubert, J.; Begriche, K.; Knockaert, L.; Robin, M.-A.; Fromenty, B. Increased expression of cytochrome P450. 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role. Clin. Res. Hepatol. Gastroenterol. 2011, 35, 630-637.
-
(2011)
Clin. Res. Hepatol. Gastroenterol
, vol.35
, pp. 630-637
-
-
Aubert, J.1
Begriche, K.2
Knockaert, L.3
Robin, M.-A.4
Fromenty, B.5
-
125
-
-
0030935567
-
Cytochrome P-4502E1: Its physiological and pathological role
-
Lieber, C.S. Cytochrome P-4502E1: Its physiological and pathological role. Physiol. Rev. 1997, 77, 517-544.
-
(1997)
Physiol. Rev
, vol.77
, pp. 517-544
-
-
Lieber, C.S.1
-
126
-
-
69549138691
-
Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease
-
Kathirvel, E.; Morgan, K.; French, S.W.; Morgan, T.R. Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease. Eur. J. Gastroenterol. Hepatol. 2009, 21, 973-983.
-
(2009)
Eur. J. Gastroenterol. Hepatol
, vol.21
, pp. 973-983
-
-
Kathirvel, E.1
Morgan, K.2
French, S.W.3
Morgan, T.R.4
-
127
-
-
0034092716
-
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
-
Leclercq, I.A.; Farrell, G.C.; Field, J.; Bell, D.R.; Gonzalez, F.J.; Robertson, G.R. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J. Clin. Investig. 2000, 105, 1067-1075.
-
(2000)
J. Clin. Investig
, vol.105
, pp. 1067-1075
-
-
Leclercq, I.A.1
Farrell, G.C.2
Field, J.3
Bell, D.R.4
Gonzalez, F.J.5
Robertson, G.R.6
-
128
-
-
84866421262
-
Critical role of cytochrome P450.2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis
-
Abdelmegeed, M.A.; Banerjee, A.; Yoo, S.-H.; Jang, S.; Gonzalez, F.J.; Song, B.-J. Critical role of cytochrome P450.2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis. J. Hepatol. 2012, 57, 860-866.
-
(2012)
J. Hepatol
, vol.57
, pp. 860-866
-
-
Abdelmegeed, M.A.1
Banerjee, A.2
Yoo, S.-H.3
Jang, S.4
Gonzalez, F.J.5
Song, B.-J.6
-
129
-
-
84857350273
-
Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance
-
Zong, H.; Armoni, M.; Harel, C.; Karnieli, E.; Pessin, J.E. Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 2012, 302, E532-E539.
-
(2012)
Am. J. Physiol. Endocrinol. Metab
, vol.302
-
-
Zong, H.1
Armoni, M.2
Harel, C.3
Karnieli, E.4
Pessin, J.E.5
-
130
-
-
84870986481
-
Toll-like receptors in liver disease
-
Petrasek, J.; Csak, T.; Szabo, G. Toll-like receptors in liver disease. Adv. Clin. Chem. 2012, 59, 155-201.
-
(2012)
Adv. Clin. Chem
, vol.59
, pp. 155-201
-
-
Petrasek, J.1
Csak, T.2
Szabo, G.3
-
131
-
-
84891837187
-
Toll-like receptors and liver disease
-
doi: 10.1111/liv.12315
-
Kesar, V.; Odin, J.A. Toll-like receptors and liver disease. Liver Int. 2013, doi: 10.1111/liv.12315.
-
(2013)
Liver Int
-
-
Kesar, V.1
Odin, J.A.2
-
132
-
-
0037080024
-
Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines
-
Zarember, K.A.; Godowski, P.J. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J. Immunol. 2002, 168, 554-561.
-
(2002)
J. Immunol
, vol.168
, pp. 554-561
-
-
Zarember, K.A.1
Godowski, P.J.2
-
133
-
-
0036785630
-
Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice
-
Seki, E.; Tsutsui, H.; Tsuji, N.M.; Hayashi, N.; Adachi, K.; Nakano, H.; Futatsugi-Yumikura, S.; Takeuchi, O.; Hoshino, K.; Akira, S. Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice. J. Immunol. 2002, 169, 3863-3868.
-
(2002)
J. Immunol
, vol.169
, pp. 3863-3868
-
-
Seki, E.1
Tsutsui, H.2
Tsuji, N.M.3
Hayashi, N.4
Adachi, K.5
Nakano, H.6
Futatsugi-Yumikura, S.7
Takeuchi, O.8
Hoshino, K.9
Akira, S.10
-
134
-
-
0028917669
-
Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge
-
Knoll, P.; Schlaak, J.; Uhrig, A.; Kempf, P.; Zum Büschenfelde, K.-H.M.; Gerken, G. Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge. J. Hepatol. 1995, 22, 226-229.
-
(1995)
J. Hepatol
, vol.22
, pp. 226-229
-
-
Knoll, P.1
Schlaak, J.2
Uhrig, A.3
Kempf, P.4
Büschenfelde, K.-H.M.Z.5
Gerken, G.6
-
135
-
-
84891406185
-
Lycopene and Cancer
-
New York, NY, USA
-
Ford, N.; Erdman, J.W., Jr. Lycopene and Cancer. In Carotenoids and Human Health; Springer: New York, NY, USA, 2013; pp. 193-214.
-
(2013)
Carotenoids and Human Health; Springer
, pp. 193-214
-
-
Ford, N.1
Erdman Jr., J.W.2
-
136
-
-
77955277583
-
An update on the health effects of tomato lycopene
-
Story, E.N.; Kopec, R.E.; Schwartz, S.J.; Harris, G.K. An update on the health effects of tomato lycopene. Annu. Rev. Food Sci. Technol. 2010, 1, 189-210.
-
(2010)
Annu. Rev. Food Sci. Technol
, vol.1
, pp. 189-210
-
-
Story, E.N.1
Kopec, R.E.2
Schwartz, S.J.3
Harris, G.K.4
-
137
-
-
0033577044
-
Tomatoes, tomato-based products, lycopene, and cancer: Review of the epidemiologic literature
-
Giovannucci, E. Tomatoes, tomato-based products, lycopene, and cancer: Review of the epidemiologic literature. J. Natl. Cancer Inst. 1999, 91, 317-331.
-
(1999)
J. Natl. Cancer Inst
, vol.91
, pp. 317-331
-
-
Giovannucci, E.1
-
138
-
-
77949798301
-
Identification and quantification of apo-lycopenals in fruits, vegetables, and human plasma
-
Kopec, R.E.; Riedl, K.M.; Harrison, E.H.; Curley, R.W., Jr.; Hruszkewycz, D.P.; Clinton, S.K.; Schwartz, S.J. Identification and quantification of apo-lycopenals in fruits, vegetables, and human plasma. J. Agric. Food Chem. 2010, 58, 3290-3296.
-
(2010)
J. Agric. Food Chem
, vol.58
, pp. 3290-3296
-
-
Kopec, R.E.1
Riedl, K.M.2
Harrison, E.H.3
Curley Jr., R.W.4
Hruszkewycz, D.P.5
Clinton, S.K.6
Schwartz, S.J.7
-
139
-
-
77949876397
-
Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats
-
Wang, Y.; Ausman, L.M.; Greenberg, A.S.; Russell, R.M.; Wang, X.D. Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats. Int. J. Cancer 2010, 126, 1788-1796.
-
(2010)
Int. J. Cancer
, vol.126
, pp. 1788-1796
-
-
Wang, Y.1
Ausman, L.M.2
Greenberg, A.S.3
Russell, R.M.4
Wang, X.D.5
-
140
-
-
84867822382
-
Lycopene metabolism and its biological significance
-
Wang, X.D. Lycopene metabolism and its biological significance. Am. J. Clin. Nutr. 2012, 96, 1214S-1222S.
-
(2012)
Am. J. Clin. Nutr
, vol.96
-
-
Wang, X.D.1
-
141
-
-
33748951012
-
Lycopene
-
Rao, A.V.; Ray, M.R.; Rao, L.G. Lycopene. Adv. Food Nutr. Res. 2006, 51, 99-164.
-
(2006)
Adv. Food Nutr. Res
, vol.51
, pp. 99-164
-
-
Rao, A.V.1
Ray, M.R.2
Rao, L.G.3
-
142
-
-
0028149484
-
Tomatoes and risk of digestive-tract cancers
-
Franceschi, S.; Bidoli, E.; Vecchia, C.L.; Talamini, R.; DAvanzo, B.; Negri, E. Tomatoes and risk of digestive-tract cancers. Int. J. Cancer 1994, 59, 181-184.
-
(1994)
Int. J. Cancer
, vol.59
, pp. 181-184
-
-
Franceschi, S.1
Bidoli, E.2
Vecchia, C.L.3
Talamini, R.4
DAvanzo, B.5
Negri, E.6
-
143
-
-
0021964522
-
Increased green and yellow vegetable intake and lowered cancer deaths in an elderly population
-
Colditz, G.A.; Branch, L.G.; Lipnick, R.J.; Willett, W.; Rosner, B.; Posner, B.; Hennekens, C. Increased green and yellow vegetable intake and lowered cancer deaths in an elderly population. Am. J. Clin. Nutr. 1985, 41, 32-36.
-
(1985)
Am. J. Clin. Nutr
, vol.41
, pp. 32-36
-
-
Colditz, G.A.1
Branch, L.G.2
Lipnick, R.J.3
Willett, W.4
Rosner, B.5
Posner, B.6
Hennekens, C.7
-
144
-
-
0037029080
-
A prospective study of tomato products, lycopene, and prostate cancer risk
-
Giovannucci, E.; Rimm, E.B.; Liu, Y.; Stampfer, M.J.; Willett, W.C. A prospective study of tomato products, lycopene, and prostate cancer risk. J. Natl. Cancer Inst. 2002, 94, 391-398.
-
(2002)
J. Natl. Cancer Inst
, vol.94
, pp. 391-398
-
-
Giovannucci, E.1
Rimm, E.B.2
Liu, Y.3
Stampfer, M.J.4
Willett, W.C.5
-
145
-
-
0028885072
-
Intake of carotenoids and retino in relation to risk of prostate cancer
-
Giovannucci, E.; Ascherio, A.; Rimm, E.B.; Stampfer, M.J.; Colditz, G.A.; Willett, W.C. Intake of carotenoids and retino in relation to risk of prostate cancer. J. Natl. Cancer Inst. 1995, 87, 1767-1776.
-
(1995)
J. Natl. Cancer Inst
, vol.87
, pp. 1767-1776
-
-
Giovannucci, E.1
Ascherio, A.2
Rimm, E.B.3
Stampfer, M.J.4
Colditz, G.A.5
Willett, W.C.6
-
146
-
-
33645740759
-
Prediagnostic level of serum retinol in relation to reduced risk of hepatocellular carcinoma
-
Yuan, J.-M.; Gao, Y.-T.; Ong, C.-N.; Ross, R.K.; Mimi, C.Y. Prediagnostic level of serum retinol in relation to reduced risk of hepatocellular carcinoma. J. Natl. Cancer Inst. 2006, 98, 482-490.
-
(2006)
J. Natl. Cancer Inst
, vol.98
, pp. 482-490
-
-
Yuan, J.-M.1
Gao, Y.-T.2
Ong, C.-N.3
Ross, R.K.4
Mimi, C.Y.5
-
147
-
-
0033119878
-
Plasma carotenoids, glutathione S-transferase M1 and T1 genetic polymorphisms, and risk of hepatocellular carcinoma: Independent and interactive effects
-
Yu, M.-W.; Chiu, Y.-H.; Chiang, Y.-C.; Chen, C.-H.; Lee, T.-H.; Santella, R.M.; Chern, H.-D.; Liaw, Y.-F.; Chen, C.-J. Plasma carotenoids, glutathione S-transferase M1 and T1 genetic polymorphisms, and risk of hepatocellular carcinoma: Independent and interactive effects. Am. J. Epidemiol. 1999, 149, 621-629.
-
(1999)
Am. J. Epidemiol
, vol.149
, pp. 621-629
-
-
Yu, M.-W.1
Chiu, Y.-H.2
Chiang, Y.-C.3
Chen, C.-H.4
Lee, T.-H.5
Santella, R.M.6
Chern, H.-D.7
Liaw, Y.-F.8
Chen, C.-J.9
-
148
-
-
79952784603
-
Plasma levels of vitamin E and carotenoids are decreased in patients with nonalcoholic steatohepatitis (NASH)
-
Erhardt, A.; Stahl, W.; Sies, H.; Lirussi, F.; Donner, A.; Haussinger, D. Plasma levels of vitamin E and carotenoids are decreased in patients with nonalcoholic steatohepatitis (NASH). Eur. J. Med. Res. 2011, 16, 76-78.
-
(2011)
Eur. J. Med. Res
, vol.16
, pp. 76-78
-
-
Erhardt, A.1
Stahl, W.2
Sies, H.3
Lirussi, F.4
Donner, A.5
Haussinger, D.6
-
149
-
-
40449110427
-
Lycopene inhibits experimental metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice
-
Huang, C.S.; Liao, J.W.; Hu, M.L. Lycopene inhibits experimental metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice. J. Nutr. 2008, 138, 538-543.
-
(2008)
J. Nutr
, vol.138
, pp. 538-543
-
-
Huang, C.S.1
Liao, J.W.2
Hu, M.L.3
-
150
-
-
24744436403
-
Lycopene inhibits cell migration and invasion and upregulates Nm23-H1 in a highly invasive hepatocarcinoma, SK-Hep-1 cells
-
Huang, C.S.; Shih, M.K.; Chuang, C.H.; Hu, M.L. Lycopene inhibits cell migration and invasion and upregulates Nm23-H1 in a highly invasive hepatocarcinoma, SK-Hep-1 cells. J. Nutr. 2005, 135, 2119-2123.
-
(2005)
J. Nutr
, vol.135
, pp. 2119-2123
-
-
Huang, C.S.1
Shih, M.K.2
Chuang, C.H.3
Hu, M.L.4
-
151
-
-
0030726136
-
Dietary lycopene decreases the initiation of liver preneoplastic foci by diethylnitrosamine in the rat
-
Astorg, P.; Gradelet, S.; Berges, R.; Suschetet, M. Dietary lycopene decreases the initiation of liver preneoplastic foci by diethylnitrosamine in the rat. Nutr. Cancer 1997, 29, 60-68.
-
(1997)
Nutr. Cancer
, vol.29
, pp. 60-68
-
-
Astorg, P.1
Gradelet, S.2
Berges, R.3
Suschetet, M.4
-
152
-
-
0028856031
-
Suppression by carotenoids of microtenoids of microcystin-induced morphological changes in mouse hepatocytes
-
Matsushima-Nishiwaki, R.; Shidoji, Y.; Nishiwaki, S.; Yamada, T.; Moriwaki, H.; Muto, Y. Suppression by carotenoids of microtenoids of microcystin-induced morphological changes in mouse hepatocytes. Lipids 1995, 30, 1029-1034.
-
(1995)
Lipids
, vol.30
, pp. 1029-1034
-
-
Matsushima-Nishiwaki, R.1
Shidoji, Y.2
Nishiwaki, S.3
Yamada, T.4
Moriwaki, H.5
Muto, Y.6
-
153
-
-
1342322806
-
Inhibitory effects of lutein and lycopene on placental glutathione S-transferase-positive preneoplastic lesions and DNA strand breakage induced in Wistar rats by the resistant hepatocyte model of hepatocarcinogenesis
-
Toledo, L.P.; Ong, T.P.; Pinho, A.L.; Jordao, A., Jr.; Vanucchi, H.; Moreno, F.S. Inhibitory effects of lutein and lycopene on placental glutathione S-transferase-positive preneoplastic lesions and DNA strand breakage induced in Wistar rats by the resistant hepatocyte model of hepatocarcinogenesis. Nutr. Cancer 2003, 47, 62-69.
-
(2003)
Nutr. Cancer
, vol.47
, pp. 62-69
-
-
Toledo, L.P.1
Ong, T.P.2
Pinho, A.L.3
Jordao Jr., A.4
Vanucchi, H.5
Moreno, F.S.6
-
154
-
-
0034819804
-
Effects of lycopene and Sho-saiko-to on hepatocarcinogenesis in a rat model of spontaneous liver cancer
-
Watanabe, S.; Kitade, Y.; Masaki, T.; Nishioka, M.; Satoh, K.; Nishino, H. Effects of lycopene and Sho-saiko-to on hepatocarcinogenesis in a rat model of spontaneous liver cancer. Nutr. Cancer 2001, 39, 96-101.
-
(2001)
Nutr. Cancer
, vol.39
, pp. 96-101
-
-
Watanabe, S.1
Kitade, Y.2
Masaki, T.3
Nishioka, M.4
Satoh, K.5
Nishino, H.6
-
155
-
-
16544366000
-
Enzymatic and oxidative metabolites of lycopene
-
Lucia dos Anjos Ferreira, A.; Yeum, K.-J.; Russell, R.M.; Krinsky, N.I.; Tang, G. Enzymatic and oxidative metabolites of lycopene. J. Nutr. Biochem. 2004, 15, 493-502.
-
(2004)
J. Nutr. Biochem
, vol.15
, pp. 493-502
-
-
Lucia dos Anjos Ferreira, A.1
Yeum, K.-J.2
Russell, R.M.3
Krinsky, N.I.4
Tang, G.5
-
157
-
-
0035104111
-
Formation of cleavage products by autoxidation of lycopene
-
Kim, S.-J.; Nara, E.; Kobayashi, H.; Terao, J.; Nagao, A. Formation of cleavage products by autoxidation of lycopene. Lipids 2001, 36, 191-200.
-
(2001)
Lipids
, vol.36
, pp. 191-200
-
-
Kim, S.-J.1
Nara, E.2
Kobayashi, H.3
Terao, J.4
Nagao, A.5
-
158
-
-
0344198052
-
Cleavage products of lycopene produced by in vitro oxidations: Characterization and mechanisms of formation
-
Caris-Veyrat, C.; Schmid, A.; Carail, M.; Böhm, V. Cleavage products of lycopene produced by in vitro oxidations: Characterization and mechanisms of formation. J. Agric. Food Chem. 2003, 51, 7318-7325.
-
(2003)
J. Agric. Food Chem
, vol.51
, pp. 7318-7325
-
-
Caris-Veyrat, C.1
Schmid, A.2
Carail, M.3
Böhm, V.4
-
159
-
-
70449461327
-
Lycopene epoxides and apo-lycopenals formed by chemical reactions and autoxidation in model systems and processed foods
-
Rodriguez, E.B.; Rodriguez-Amaya, D.B. Lycopene epoxides and apo-lycopenals formed by chemical reactions and autoxidation in model systems and processed foods. J. Food Sci. 2009, 74, C674-C682.
-
(2009)
J. Food Sci
, vol.74
-
-
Rodriguez, E.B.1
Rodriguez-Amaya, D.B.2
-
160
-
-
33745946053
-
Vitamin synthesis in plants: Tocopherols and carotenoids
-
DellaPenna, D.; Pogson, B.J. Vitamin synthesis in plants: Tocopherols and carotenoids. Annu. Rev. Plant Biol. 2006, 57, 711-738.
-
(2006)
Annu. Rev. Plant Biol
, vol.57
, pp. 711-738
-
-
Dellapenna, D.1
Pogson, B.J.2
-
161
-
-
0000744072
-
Effect of food preparation on qualitative and quantitative distribution of major carotenoid constituents of tomatoes and several green vegetables
-
Khachik, F.; Goli, M.B.; Beecher, G.R.; Holden, J.; Lusby, W.R.; Tenorio, M.D.; Barrera, M.R. Effect of food preparation on qualitative and quantitative distribution of major carotenoid constituents of tomatoes and several green vegetables. J. Agric. Food Chem. 1992, 40, 390-398.
-
(1992)
J. Agric. Food Chem
, vol.40
, pp. 390-398
-
-
Khachik, F.1
Goli, M.B.2
Beecher, G.R.3
Holden, J.4
Lusby, W.R.5
Tenorio, M.D.6
Barrera, M.R.7
-
162
-
-
0021269347
-
Separation carotenoids by high-performance liquid chromatography: III. 1,2-Epoxycarotenoids
-
Kamber, M.; Pfander, H. Separation carotenoids by high-performance liquid chromatography: III. 1,2-Epoxycarotenoids. J. Chromatogr. 1984, 295, 295-298.
-
(1984)
J. Chromatogr
, vol.295
, pp. 295-298
-
-
Kamber, M.1
Pfander, H.2
-
163
-
-
0343809609
-
Carotene epoxides from the delta tomato mutant
-
Britton, G.; Goodwin, T.W. Carotene epoxides from the delta tomato mutant. Phytochemistry 1975, 14, 2530-2532.
-
(1975)
Phytochemistry
, vol.14
, pp. 2530-2532
-
-
Britton, G.1
Goodwin, T.W.2
-
164
-
-
0005839532
-
Carotene epoxides of Lycopersicon esculentum
-
Ben-Aziz, A.; Britton, G.; Goodwin, T.W. Carotene epoxides of Lycopersicon esculentum. Phytochemistry 1973, 12, 2759-2764.
-
(1973)
Phytochemistry
, vol.12
, pp. 2759-2764
-
-
Ben-Aziz, A.1
Britton, G.2
Goodwin, T.W.3
-
165
-
-
84878995360
-
Carotenoid metabolism in mammals, including man: Formation, occurrence, and function of apocarotenoids thematic review series: Fat-soluble vitamins: Vitamin A
-
Eroglu, A.; Harrison, E.H. Carotenoid metabolism in mammals, including man: Formation, occurrence, and function of apocarotenoids thematic review series: Fat-soluble vitamins: Vitamin A. J. Lipid Res. 2013, 54, 1719-1730.
-
(2013)
J. Lipid Res
, vol.54
, pp. 1719-1730
-
-
Eroglu, A.1
Harrison, E.H.2
-
166
-
-
0035816626
-
Characterization of a novel carotenoid cleavage dioxygenase from plants
-
Schwartz, S.H.; Qin, X.; Zeevaart, J.A. Characterization of a novel carotenoid cleavage dioxygenase from plants. J. Biol. Chem. 2001, 276, 25208-25211.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 25208-25211
-
-
Schwartz, S.H.1
Qin, X.2
Zeevaart, J.A.3
-
167
-
-
84891438061
-
Carotenoid Cleavage Dioxygenase and Presence of Apo-Carotenoids in Biological Matrices
-
Washington, DC, USA
-
Rachel, E.K.; Steven, J.S. Carotenoid Cleavage Dioxygenase and Presence of Apo-Carotenoids in Biological Matrices. In Carotenoid Cleavage Products; American Chemical Society: Washington, DC, USA, 2013; pp. 31-41.
-
(2013)
Carotenoid Cleavage Products; American Chemical Society
, pp. 31-41
-
-
Rachel, E.K.1
Steven, J.S.2
-
168
-
-
84905391328
-
Carotenoid Cleavage Dioxygenase Genes from Fruit
-
American Chemical Society: Washington, DC, USA
-
Wilfried, S.; Fong-Chin, H.; Péter, M. Carotenoid Cleavage Dioxygenase Genes from Fruit. In Carotenoid Cleavage Products; American Chemical Society: Washington, DC, USA, 2013; pp. 11-19.
-
(2013)
Carotenoid Cleavage Products
, pp. 11-19
-
-
Wilfried, S.1
Fong-Chin, H.2
Péter, M.3
-
169
-
-
8744286799
-
The biochemical characterization of two carotenoid cleavage enzymes from Arabidopsis indicates that a carotenoid-derived compound inhibits lateral branching
-
Schwartz, S.H.; Qin, X.; Loewen, M.C. The biochemical characterization of two carotenoid cleavage enzymes from Arabidopsis indicates that a carotenoid-derived compound inhibits lateral branching. J. Biol. Chem. 2004, 279, 46940-46945.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 46940-46945
-
-
Schwartz, S.H.1
Qin, X.2
Loewen, M.C.3
-
170
-
-
33748641523
-
Molecular cloning of the rat β-carotene 15,15′-monooxygenase gene and its regulation by retinoic acid
-
Takitani, K.; Zhu, C.-L.; Inoue, A.; Tamai, H. Molecular cloning of the rat β-carotene 15,15′-monooxygenase gene and its regulation by retinoic acid. Eur. J. Nutr. 2006, 45, 320-326.
-
(2006)
Eur. J. Nutr
, vol.45
, pp. 320-326
-
-
Takitani, K.1
Zhu, C.-L.2
Inoue, A.3
Tamai, H.4
-
171
-
-
0034697178
-
Filling the gap in vitamin A research. Molecular identification of an enzyme cleaving β-carotene to retinal
-
Von Lintig, J.; Vogt, K. Filling the gap in vitamin A research. Molecular identification of an enzyme cleaving β-carotene to retinal. J. Biol. Chem. 2000, 275, 11915-11920.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 11915-11920
-
-
von Lintig, J.1
Vogt, K.2
-
172
-
-
0034630745
-
Cloning and expression of β,β-carotene 15,15′-dioxygenase
-
Wyss, A.; Wirtz, G.; Woggon, W.-D.; Brugger, R.; Wyss, M.; Friedlein, A.; Bachmann, H.; Hunziker, W. Cloning and expression of β,β-carotene 15,15′-dioxygenase. Biochem. Biophys. Res. Commun. 2000, 271, 334-336.
-
(2000)
Biochem. Biophys. Res. Commun
, vol.271
, pp. 334-336
-
-
Wyss, A.1
Wirtz, G.2
Woggon, W.-D.3
Brugger, R.4
Wyss, M.5
Friedlein, A.6
Bachmann, H.7
Hunziker, W.8
-
173
-
-
0037189569
-
Biochemical properties of purified recombinant human β-carotene 15,15′-monooxygenase
-
Lindqvist, A.; Andersson, S. Biochemical properties of purified recombinant human β-carotene 15,15′-monooxygenase. J. Biol. Chem. 2002, 277, 23942-23948.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 23942-23948
-
-
Lindqvist, A.1
Andersson, S.2
-
174
-
-
0035794153
-
Identification, expression, and substrate specificity of a mammalian β-carotene 15,15′-dioxygenase
-
Redmond, T.M.; Gentleman, S.; Duncan, T.; Yu, S.; Wiggert, B.; Gantt, E.; Cunningham, F.X. Identification, expression, and substrate specificity of a mammalian β-carotene 15,15′-dioxygenase. J. Biol. Chem. 2001, 276, 6560-6565.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 6560-6565
-
-
Redmond, T.M.1
Gentleman, S.2
Duncan, T.3
Yu, S.4
Wiggert, B.5
Gantt, E.6
Cunningham, F.X.7
-
175
-
-
84891437288
-
Substrate specificity of purified recombinant human β-carotene 15,15′-oxygenase (BCO1)
-
doi: 10.1074/jbc.M113.507160
-
Dela Sena, C.; Narayanasamy, S.; Riedl, K.M.; Curley, R.W.; Schwartz, S.J.; Harrison, E.H. Substrate specificity of purified recombinant human β-carotene 15,15′-oxygenase (BCO1). J. Biol. Chem. 2013, doi: 10.1074/jbc.M113.507160.
-
(2013)
J. Biol. Chem
-
-
Dela Sena, C.1
Narayanasamy, S.2
Riedl, K.M.3
Curley, R.W.4
Schwartz, S.J.5
Harrison, E.H.6
-
176
-
-
0035280250
-
Cloning and characterization of a human β,β-carotene-15,15′-dioxygenase that is highly expressed in the retinal pigment epithelium
-
Yan, W.; Jang, G.F.; Haeseleer, F.; Esumi, N.; Chang, J.; Kerrigan, M.; Campochiaro, M.; Campochiaro, P.; Palczewski, K.; Zack, D.J. Cloning and characterization of a human β,β-carotene-15,15′-dioxygenase that is highly expressed in the retinal pigment epithelium. Genomics 2001, 72, 193-202.
-
(2001)
Genomics
, vol.72
, pp. 193-202
-
-
Yan, W.1
Jang, G.F.2
Haeseleer, F.3
Esumi, N.4
Chang, J.5
Kerrigan, M.6
Campochiaro, M.7
Campochiaro, P.8
Palczewski, K.9
Zack, D.J.10
-
177
-
-
0028145486
-
Enzymatic formation of 9-cis, 13-cis, and all-trans retinals from isomers of β-carotene
-
Nagao, A.; Olson, J.A. Enzymatic formation of 9-cis, 13-cis, and all-trans retinals from isomers of β-carotene. FASEB J. 1994, 8, 968-973.
-
(1994)
FASEB J
, vol.8
, pp. 968-973
-
-
Nagao, A.1
Olson, J.A.2
-
178
-
-
79956321744
-
Lycopene bioavailability and metabolism in humans: An accelerator mass spectrometry study
-
Ross, A.B.; Ruckle, J.; Synal, H.A.; Schulze-König, T.; Wertz, K.; Rümbeli, R.; Liberman, R.G.; Skipper, P.L.; Tannenbaum, S.R.; Bourgeois, A. Lycopene bioavailability and metabolism in humans: An accelerator mass spectrometry study. Am. J. Clin. Nutr. 2011, 93, 1263-1273.
-
(2011)
Am. J. Clin. Nutr
, vol.93
, pp. 1263-1273
-
-
Ross, A.B.1
Ruckle, J.2
Synal, H.A.3
Schulze-König, T.4
Wertz, K.5
Rümbeli, R.6
Liberman, R.G.7
Skipper, P.L.8
Tannenbaum, S.R.9
Bourgeois, A.10
-
179
-
-
0035957943
-
Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A
-
Kiefer, C.; Hessel, S.; Lampert, J.M.; Vogt, K.; Lederer, M.O.; Breithaupt, D.E.; von Lintig, J. Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. J. Biol. Chem. 2001, 276, 14110-14116.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 14110-14116
-
-
Kiefer, C.1
Hessel, S.2
Lampert, J.M.3
Vogt, K.4
Lederer, M.O.5
Breithaupt, D.E.6
von Lintig, J.7
-
180
-
-
33745828641
-
The biochemical characterization of ferret carotene-9′,10′-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo
-
Hu, K.Q.; Liu, C.; Ernst, H.; Krinsky, N.I.; Russell, R.M.; Wang, X.D. The biochemical characterization of ferret carotene-9′,10′-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. J. Biol. Chem. 2006, 281, 19327-19338.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 19327-19338
-
-
Hu, K.Q.1
Liu, C.2
Ernst, H.3
Krinsky, N.I.4
Russell, R.M.5
Wang, X.D.6
-
181
-
-
79954601092
-
A mitochondrial enzyme degrades carotenoids and protects against oxidative stress
-
Amengual, J.; Lobo, G.P.; Golczak, M.; Li, H.N.M.; Klimova, T.; Hoppel, C.L.; Wyss, A.; Palczewski, K.; von Lintig, J. A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. FASEB J. 2011, 25, 948-959.
-
(2011)
FASEB J
, vol.25
, pp. 948-959
-
-
Amengual, J.1
Lobo, G.P.2
Golczak, M.3
Li, H.N.M.4
Klimova, T.5
Hoppel, C.L.6
Wyss, A.7
Palczewski, K.8
von Lintig, J.9
-
182
-
-
78649564234
-
Loss of carotene-9′,10′- monooxygenase expression increases serum and tissue lycopene concentrations in lycopene-fed mice
-
Ford, N.A.; Clinton, S.K.; von Lintig, J.; Wyss, A.; Erdman, J.W. Loss of carotene-9′,10′- monooxygenase expression increases serum and tissue lycopene concentrations in lycopene-fed mice. J. Nutr. 2010, 140, 2134-2138.
-
(2010)
J. Nutr
, vol.140
, pp. 2134-2138
-
-
Ford, N.A.1
Clinton, S.K.2
von Lintig, J.3
Wyss, A.4
Erdman, J.W.5
-
183
-
-
27244447697
-
Cell type-specific expression of β-carotene 9′,10′-monooxygenase in human tissues
-
Lindqvist, A.; He, Y.G.; Andersson, S. Cell type-specific expression of β-carotene 9′,10′-monooxygenase in human tissues. J. Histochem. Cytochem. 2005, 53, 1403-1412.
-
(2005)
J. Histochem. Cytochem
, vol.53
, pp. 1403-1412
-
-
Lindqvist, A.1
He, Y.G.2
Andersson, S.3
-
184
-
-
84858318259
-
Importance of β-carotene 15,15′-monooxygenase 1 (BCMO1) and β-carotene 9′,10′-dioxygenase 2 (BCDO2) in nutrition and health
-
Lietz, G.; Oxley, A.; Boesch-Saadatmandi, C.; Kobayashi, D. Importance of β-carotene 15,15′-monooxygenase 1 (BCMO1) and β-carotene 9′,10′-dioxygenase 2 (BCDO2) in nutrition and health. Mol. Nutr. Food Res. 2012, 56, 241-250.
-
(2012)
Mol. Nutr. Food Res
, vol.56
, pp. 241-250
-
-
Lietz, G.1
Oxley, A.2
Boesch-Saadatmandi, C.3
Kobayashi, D.4
-
185
-
-
77950890497
-
Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels
-
He, M.; Cornelis, M.C.; Kraft, P.; van Dam, R.M.; Sun, Q.; Laurie, C.C.; Mirel, D.B.; Chasman, D.I.; Ridker, P.M.; Hunter, D.J. Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels. Arterioscler. Thromb. Vasc. Biol. 2010, 30, 885-890.
-
(2010)
Arterioscler. Thromb. Vasc. Biol
, vol.30
, pp. 885-890
-
-
He, M.1
Cornelis, M.C.2
Kraft, P.3
van Dam, R.M.4
Sun, Q.5
Laurie, C.C.6
Mirel, D.B.7
Chasman, D.I.8
Ridker, P.M.9
Hunter, D.J.10
-
186
-
-
84858302897
-
Do single nucleotide polymorphisms in β-carotene dioxygenase-2 (BCDO2) gene affect the postprandial response?
-
Tourniaire, F.; Minihane, A.M.; Hesketh, J.; Lietz, G. Do single nucleotide polymorphisms in β-carotene dioxygenase-2 (BCDO2) gene affect the postprandial response? Proc. Nutr. Soc. 2008, 67, E187.
-
(2008)
Proc. Nutr. Soc
, vol.67
-
-
Tourniaire, F.1
Minihane, A.M.2
Hesketh, J.3
Lietz, G.4
-
187
-
-
77952068017
-
Genetic variation in the β,β-carotene-9′,10′-dioxygenase gene and association with fat colour in bovine adipose tissue and milk
-
Tian, R.; Pitchford, W.S.; Morris, C.A.; Cullen, N.G.; Bottema, C.D. Genetic variation in the β,β-carotene-9′,10′-dioxygenase gene and association with fat colour in bovine adipose tissue and milk. Anim. Genet. 2010, 41, 253-259.
-
(2010)
Anim. Genet
, vol.41
, pp. 253-259
-
-
Tian, R.1
Pitchford, W.S.2
Morris, C.A.3
Cullen, N.G.4
Bottema, C.D.5
-
188
-
-
70349318148
-
Mutation in bovine β-carotene oxygenase 2 affects milk color
-
Berry, S.D.; Davis, S.R.; Beattie, E.M.; Thomas, N.L.; Burrett, A.K.; Ward, H.E.; Stanfield, A.M.; Biswas, M.; Ankersmit-Udy, A.E.; Oxley, P.E., et al. Mutation in bovine β-carotene oxygenase 2 affects milk color. Genetics 2009, 182, 923-926.
-
(2009)
Genetics
, vol.182
, pp. 923-926
-
-
Berry, S.D.1
Davis, S.R.2
Beattie, E.M.3
Thomas, N.L.4
Burrett, A.K.5
Ward, H.E.6
Stanfield, A.M.7
Biswas, M.8
Ankersmit-Udy, A.E.9
Oxley, P.E.10
-
189
-
-
77649110092
-
A nonsense mutation in the β-carotene oxygenase 2 (BCO2) gene is tightly associated with accumulation of carotenoids in adipose tissue in sheep (Ovis aries)
-
Vage, D.I.; Boman, I.A. A nonsense mutation in the β-carotene oxygenase 2 (BCO2) gene is tightly associated with accumulation of carotenoids in adipose tissue in sheep (Ovis aries). BMC Genet. 2010, 11, 10.
-
(2010)
BMC Genet
, vol.11
, pp. 10
-
-
Vage, D.I.1
Boman, I.A.2
-
190
-
-
40149109370
-
Identification of the yellow skin gene reveals a hybrid origin of the domestic chicken
-
Eriksson, J.; Larson, G.; Gunnarsson, U.; Bed'hom, B.; Tixier-Boichard, M.; Stromstedt, L.; Wright, D.; Jungerius, A.; Vereijken, A.; Randi, E., et al. Identification of the yellow skin gene reveals a hybrid origin of the domestic chicken. PLoS Genet. 2008, 4, e1000010.
-
(2008)
PLoS Genet
, vol.4
-
-
Eriksson, J.1
Larson, G.2
Gunnarsson, U.3
Bed'hom, B.4
Tixier-Boichard, M.5
Stromstedt, L.6
Wright, D.7
Jungerius, A.8
Vereijken, A.9
Randi, E.10
-
191
-
-
0038676914
-
Carotenoid oxygenases: Cleave it or leave it
-
Giuliano, G.; Al-Babili, S.; von Lintig, J. Carotenoid oxygenases: Cleave it or leave it. Trends Plant Sci. 2003, 8, 145-149.
-
(2003)
Trends Plant Sci
, vol.8
, pp. 145-149
-
-
Giuliano, G.1
Al-Babili, S.2
von Lintig, J.3
-
192
-
-
33646775713
-
Apo-8′-lycopenal and apo-12′-lycopenal are metabolic products of lycopene in rat liver
-
Gajic, M.; Zaripheh, S.; Sun, F.; Erdman, J.W., Jr. Apo-8′-lycopenal and apo-12′-lycopenal are metabolic products of lycopene in rat liver. J. Nutr. 2006, 136, 1552-1557.
-
(2006)
J. Nutr
, vol.136
, pp. 1552-1557
-
-
Gajic, M.1
Zaripheh, S.2
Sun, F.3
Erdman Jr., J.W.4
-
193
-
-
80155161346
-
Apo-10′-lycopenoic acid impacts adipose tissue biology via the retinoic acid receptors
-
Gouranton, E.; Aydemir, G.; Reynaud, E.; Marcotorchino, J.; Malezet, C.; Caris-Veyrat, C.; Blomhoff, R.; Landrier, J.F.; Ruhl, R. Apo-10′-lycopenoic acid impacts adipose tissue biology via the retinoic acid receptors. Biochim. Biophys. Acta 2011, 1811, 1105-1114.
-
(2011)
Biochim. Biophys. Acta
, vol.1811
, pp. 1105-1114
-
-
Gouranton, E.1
Aydemir, G.2
Reynaud, E.3
Marcotorchino, J.4
Malezet, C.5
Caris-Veyrat, C.6
Blomhoff, R.7
Landrier, J.F.8
Ruhl, R.9
-
194
-
-
84888316513
-
Two carotenoid oxygenases contribute to mammalian provitamin A metabolism
-
Amengual, J.; Widjaja-Adhi, M.A.K.; Rodriguez-Santiago, S.; Hessel, S.; Golczak, M.; Palczewski, K.; von Lintig, J. Two carotenoid oxygenases contribute to mammalian provitamin A metabolism. J. Biol. Chem. 2013, 288, 34081-34096.
-
(2013)
J. Biol. Chem
, vol.288
, pp. 34081-34096
-
-
Amengual, J.1
Widjaja-Adhi, M.A.K.2
Rodriguez-Santiago, S.3
Hessel, S.4
Golczak, M.5
Palczewski, K.6
von Lintig, J.7
-
195
-
-
0030002910
-
In vivo biosynthesis of retinoic acid from β-carotene involves and excentric cleavage pathway in ferret intestine
-
Hébuterne, X.; Wang, X.-D.; Smith, D.; Tang, G.; Russell, R.M. In vivo biosynthesis of retinoic acid from β-carotene involves and excentric cleavage pathway in ferret intestine. J. Lipid Res. 1996, 37, 482-492.
-
(1996)
J. Lipid Res
, vol.37
, pp. 482-492
-
-
Hébuterne, X.1
Wang, X.-D.2
Smith, D.3
Tang, G.4
Russell, R.M.5
-
196
-
-
84872736591
-
Acyclic retinoid in chemoprevention of hepatocellular carcinoma: Targeting phosphorylated retinoid X receptor-α for prevention of liver carcinogenesis
-
Shimizu, M.; Shirakami, Y.; Imai, K.; Takai, K.; Moriwaki, H. Acyclic retinoid in chemoprevention of hepatocellular carcinoma: Targeting phosphorylated retinoid X receptor-α for prevention of liver carcinogenesis. J. Carcinog. 2012, 11, 11.
-
(2012)
J. Carcinog
, vol.11
, pp. 11
-
-
Shimizu, M.1
Shirakami, Y.2
Imai, K.3
Takai, K.4
Moriwaki, H.5
-
197
-
-
34547800757
-
Apo-10′-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo
-
Lian, F.; Smith, D.E.; Ernst, H.; Russell, R.M.; Wang, X.D. Apo-10′-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo. Carcinogenesis 2007, 28, 1567-1574.
-
(2007)
Carcinogenesis
, vol.28
, pp. 1567-1574
-
-
Lian, F.1
Smith, D.E.2
Ernst, H.3
Russell, R.M.4
Wang, X.D.5
-
198
-
-
84862267642
-
Antimetastatic effects and mechanisms of apo-8′-lycopenal, an enzymatic metabolite of lycopene, against human hepatocarcinoma SK-Hep-1 cells
-
Yang, C.M.; Hu, T.Y.; Hu, M.L. Antimetastatic effects and mechanisms of apo-8′-lycopenal, an enzymatic metabolite of lycopene, against human hepatocarcinoma SK-Hep-1 cells. Nutr. Cancer 2012, 64, 274-285.
-
(2012)
Nutr. Cancer
, vol.64
, pp. 274-285
-
-
Yang, C.M.1
Hu, T.Y.2
Hu, M.L.3
-
199
-
-
84863266181
-
Apo-10′-lycopenoic acid, a lycopene metabolite, increases sirtuin 1 mRNA and protein levels and decreases hepatic fat accumulation in ob/ob mice
-
Chung, J.; Koo, K.; Lian, F.; Hu, K.Q.; Ernst, H.; Wang, X.D. Apo-10′-lycopenoic acid, a lycopene metabolite, increases sirtuin 1 mRNA and protein levels and decreases hepatic fat accumulation in ob/ob mice. J. Nutr. 2012, 142, 405-410.
-
(2012)
J. Nutr
, vol.142
, pp. 405-410
-
-
Chung, J.1
Koo, K.2
Lian, F.3
Hu, K.Q.4
Ernst, H.5
Wang, X.D.6
-
200
-
-
84858320870
-
Genetic variations involved in interindividual variability in carotenoid status
-
Borel, P. Genetic variations involved in interindividual variability in carotenoid status. Mol. Nutr. Food Res. 2012, 56, 228-240.
-
(2012)
Mol. Nutr. Food Res
, vol.56
, pp. 228-240
-
-
Borel, P.1
-
201
-
-
33947528675
-
An antioxidant effect by acyclic retinoid suppresses liver tumor in mice
-
Sakabe, T.; Tsuchiya, H.; Endo, M.; Tomita, A.; Ishii, K.; Gonda, K.; Murai, R.; Takubo, K.; Hoshikawa, Y.; Kurimasa, A. An antioxidant effect by acyclic retinoid suppresses liver tumor in mice. Biochem. Pharmacol. 2007, 73, 1405-1411.
-
(2007)
Biochem. Pharmacol
, vol.73
, pp. 1405-1411
-
-
Sakabe, T.1
Tsuchiya, H.2
Endo, M.3
Tomita, A.4
Ishii, K.5
Gonda, K.6
Murai, R.7
Takubo, K.8
Hoshikawa, Y.9
Kurimasa, A.10
-
202
-
-
21144458075
-
Prevention of rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TGF-α-expressing oval-like cells and activated hepatic stellate cells
-
Sano, T.; Kagawa, M.; Okuno, M.; Ishibashi, N.; Hashimoto, M.; Yamamoto, M.; Suzuki, R.; Kohno, H.; Matsushima-Nishiwaki, R.; Takano, Y., et al. Prevention of rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TGF-α-expressing oval-like cells and activated hepatic stellate cells. Nutr. Cancer 2005, 51, 197-206.
-
(2005)
Nutr. Cancer
, vol.51
, pp. 197-206
-
-
Sano, T.1
Kagawa, M.2
Okuno, M.3
Ishibashi, N.4
Hashimoto, M.5
Yamamoto, M.6
Suzuki, R.7
Kohno, H.8
Matsushima-Nishiwaki, R.9
Takano, Y.10
-
203
-
-
3042780230
-
An acyclic retinoid, NIK-333, inhibits N-diethylnitrosamine-induced rat hepatocarcinogenesis through suppression of TGF-α expression and cell proliferation
-
Kagawa, M.; Sano, T.; Ishibashi, N.; Hashimoto, M.; Okuno, M.; Moriwaki, H.; Suzuki, R.; Kohno, H.; Tanaka, T. An acyclic retinoid, NIK-333, inhibits N-diethylnitrosamine-induced rat hepatocarcinogenesis through suppression of TGF-α expression and cell proliferation. Carcinogenesis 2004, 25, 979-985.
-
(2004)
Carcinogenesis
, vol.25
, pp. 979-985
-
-
Kagawa, M.1
Sano, T.2
Ishibashi, N.3
Hashimoto, M.4
Okuno, M.5
Moriwaki, H.6
Suzuki, R.7
Kohno, H.8
Tanaka, T.9
-
204
-
-
78650936920
-
Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells
-
Tatsukawa, H.; Sano, T.; Fukaya, Y.; Ishibashi, N.; Watanabe, M.; Okuno, M.; Moriwaki, H.; Kojima, S. Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells. Mol. Cancer 2011, 10, 4.
-
(2011)
Mol. Cancer
, vol.10
, pp. 4
-
-
Tatsukawa, H.1
Sano, T.2
Fukaya, Y.3
Ishibashi, N.4
Watanabe, M.5
Okuno, M.6
Moriwaki, H.7
Kojima, S.8
-
205
-
-
4444344411
-
Acyclic retinoid activates retinoic acid receptor β and induces transcriptional activation of p21CIP1 in HepG2 human hepatoma cells
-
Suzui, M.; Shimizu, M.; Masuda, M.; Lim, J.T.; Yoshimi, N.; Weinstein, I.B. Acyclic retinoid activates retinoic acid receptor β and induces transcriptional activation of p21CIP1 in HepG2 human hepatoma cells. Mol. Cancer Ther. 2004, 3, 309-316.
-
(2004)
Mol. Cancer Ther
, vol.3
, pp. 309-316
-
-
Suzui, M.1
Shimizu, M.2
Masuda, M.3
Lim, J.T.4
Yoshimi, N.5
Weinstein, I.B.6
-
206
-
-
0037099751
-
Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1
-
Suzui, M.; Masuda, M.; Lim, J.T.; Albanese, C.; Pestell, R.G.; Weinstein, I.B. Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1. Cancer Res. 2002, 62, 3997-4006.
-
(2002)
Cancer Res
, vol.62
, pp. 3997-4006
-
-
Suzui, M.1
Masuda, M.2
Lim, J.T.3
Albanese, C.4
Pestell, R.G.5
Weinstein, I.B.6
-
207
-
-
0028939235
-
Induction of apoptosis by acyclic retinoid in the human hepatoma-derived cell line, HuH-7
-
Nakamura, N.; Shidoji, Y.; Yamada, Y.; Hatakeyama, H.; Moriwaki, H.; Muto, Y. Induction of apoptosis by acyclic retinoid in the human hepatoma-derived cell line, HuH-7. Biochem. Biophys. Res. Commun. 1995, 207, 382-388.
-
(1995)
Biochem. Biophys. Res. Commun
, vol.207
, pp. 382-388
-
-
Nakamura, N.1
Shidoji, Y.2
Yamada, Y.3
Hatakeyama, H.4
Moriwaki, H.5
Muto, Y.6
-
208
-
-
73349126408
-
Acyclic retinoid inhibits angiogenesis by suppressing the MAPK pathway
-
Komi, Y.; Sogabe, Y.; Ishibashi, N.; Sato, Y.; Moriwaki, H.; Shimokado, K.; Kojima, S. Acyclic retinoid inhibits angiogenesis by suppressing the MAPK pathway. Lab. Investig. 2010, 90, 52-60.
-
(2010)
Lab. Investig
, vol.90
, pp. 52-60
-
-
Komi, Y.1
Sogabe, Y.2
Ishibashi, N.3
Sato, Y.4
Moriwaki, H.5
Shimokado, K.6
Kojima, S.7
-
209
-
-
0033118925
-
Prevention of second primary tumors by an acyclic retinoid in patients with hepatocellular carcinoma
-
Muto, Y.; Moriwaki, H.; Saito, A. Prevention of second primary tumors by an acyclic retinoid in patients with hepatocellular carcinoma. N. Engl. J. Med. 1999, 340, 1046-1047.
-
(1999)
N. Engl. J. Med
, vol.340
, pp. 1046-1047
-
-
Muto, Y.1
Moriwaki, H.2
Saito, A.3
-
210
-
-
5844370499
-
Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group
-
Muto, Y.; Moriwaki, H.; Ninomiya, M.; Adachi, S.; Saito, A.; Takasaki, K.T.; Tanaka, T.; Tsurumi, K.; Okuno, M.; Tomita, E., et al. Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group. N. Engl. J. Med. 1996, 334, 1561-1567.
-
(1996)
N. Engl. J. Med
, vol.334
, pp. 1561-1567
-
-
Muto, Y.1
Moriwaki, H.2
Ninomiya, M.3
Adachi, S.4
Saito, A.5
Takasaki, K.T.6
Tanaka, T.7
Tsurumi, K.8
Okuno, M.9
Tomita, E.10
-
211
-
-
78650805270
-
Effect of peretinoin on recurrence of hepatocellular carcinoma (HCC): Results of a phase II/III randomized placebo-controlled trial
-
Okita, K.; Matsui, O.; Kumada, H.; Tanaka, K.; Kaneko, S.; Moriwaki, H.; Izumi, N.; Okusaka, T.; Ohashi, Y.; Makuuchi, M. Effect of peretinoin on recurrence of hepatocellular carcinoma (HCC): Results of a phase II/III randomized placebo-controlled trial. J. Clin. Oncol. 2010, 28, 4024.
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 4024
-
-
Okita, K.1
Matsui, O.2
Kumada, H.3
Tanaka, K.4
Kaneko, S.5
Moriwaki, H.6
Izumi, N.7
Okusaka, T.8
Ohashi, Y.9
Makuuchi, M.10
-
212
-
-
84865742284
-
The synergistic anti-inflammatory effect of lycopene, lutein, β-carotene and carnosic acid combinations via redox-based inhibition of NF-κB signaling
-
Hadad, N.; Levy, R. The synergistic anti-inflammatory effect of lycopene, lutein, β-carotene and carnosic acid combinations via redox-based inhibition of NF-κB signaling. Free Radic. Biol. Med. 2012, 53, 1381-1391.
-
(2012)
Free Radic. Biol. Med
, vol.53
, pp. 1381-1391
-
-
Hadad, N.1
Levy, R.2
-
213
-
-
79956282901
-
Lycopene inhibits NF-κB-mediated IL-8 expression and changes redox and PPARγ signalling in cigarette smoke-Stimulated macrophages
-
Simone, R.E.; Russo, M.; Catalano, A.; Monego, G.; Froehlich, K.; Boehm, V.; Palozza, P. Lycopene inhibits NF-κB-mediated IL-8 expression and changes redox and PPARγ signalling in cigarette smoke-Stimulated macrophages. PLoS One 2011, 6, e19652.
-
(2011)
PLoS One
, vol.6
-
-
Simone, R.E.1
Russo, M.2
Catalano, A.3
Monego, G.4
Froehlich, K.5
Boehm, V.6
Palozza, P.7
-
214
-
-
79958791073
-
Lycopene inhibits proinflammatory cytokine and chemokine expression in adipose tissue
-
Gouranton, E.; Thabuis, C.; Riollet, C.; Malezet-Desmoulins, C.; El Yazidi, C.; Amiot, M.J.; Borel, P.; Landrier, J.F. Lycopene inhibits proinflammatory cytokine and chemokine expression in adipose tissue. J. Nutr. Biochem. 2011, 22, 642-648.
-
(2011)
J. Nutr. Biochem
, vol.22
, pp. 642-648
-
-
Gouranton, E.1
Thabuis, C.2
Riollet, C.3
Malezet-Desmoulins, C.4
El Yazidi, C.5
Amiot, M.J.6
Borel, P.7
Landrier, J.F.8
-
215
-
-
77949270779
-
Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-κB in macrophages
-
Feng, D.; Ling, W.-H.; Duan, R.-D. Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-κB in macrophages. Inflamm. Res. 2010, 59, 115-121.
-
(2010)
Inflamm. Res
, vol.59
, pp. 115-121
-
-
Feng, D.1
Ling, W.-H.2
Duan, R.-D.3
-
216
-
-
4744370805
-
Lycopene suppresses the lipopolysaccharide-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and nuclear factor-κB
-
Kim, G.Y.; Kim, J.H.; Ahn, S.C.; Lee, H.J.; Moon, D.O.; Lee, C.M.; Park, Y.M. Lycopene suppresses the lipopolysaccharide-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and nuclear factor-κB. Immunology 2004, 113, 203-211.
-
(2004)
Immunology
, vol.113
, pp. 203-211
-
-
Kim, G.Y.1
Kim, J.H.2
Ahn, S.C.3
Lee, H.J.4
Moon, D.O.5
Lee, C.M.6
Park, Y.M.7
-
217
-
-
84861692997
-
Lycopene attenuates LPS-induced TNF-α secretion in macrophages and inflammatory markers in adipocytes exposed to macrophage-conditioned media
-
Marcotorchino, J.; Romier, B.; Gouranton, E.; Riollet, C.; Gleize, B.; Malezet-Desmoulins, C.; Landrier, J.F. Lycopene attenuates LPS-induced TNF-α secretion in macrophages and inflammatory markers in adipocytes exposed to macrophage-conditioned media. Mol. Nutr. Food Res. 2012, 56, 725-732.
-
(2012)
Mol. Nutr. Food Res
, vol.56
, pp. 725-732
-
-
Marcotorchino, J.1
Romier, B.2
Gouranton, E.3
Riollet, C.4
Gleize, B.5
Malezet-Desmoulins, C.6
Landrier, J.F.7
-
218
-
-
84887216118
-
Lycopene supplementation modulates plasma concentrations and epididymal adipose tissue mRNA of leptin, resistin and IL-6 in diet-induced obese rats
-
De Azevedo Melo Luvizotto, R.; Nascimento, A.F.; Imaizumi, E.; Pierine, D.T.; Conde, S.J.; Correa, C.R.; Yeum, K.-J.; Ferreira, A.L.A. Lycopene supplementation modulates plasma concentrations and epididymal adipose tissue mRNA of leptin, resistin and IL-6 in diet-induced obese rats. Br. J. Nutr. 2013, 110, 1803-1809.
-
(2013)
Br. J. Nutr
, vol.110
, pp. 1803-1809
-
-
De Azevedo, M.L.R.1
Nascimento, A.F.2
Imaizumi, E.3
Pierine, D.T.4
Conde, S.J.5
Correa, C.R.6
Yeum, K.-J.7
Ferreira, A.L.A.8
-
219
-
-
34249913180
-
Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-κB and stimulatory protein-1
-
Huang, C.-S.; Fan, Y.-E.; Lin, C.-Y.; Hu, M.-L. Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-κB and stimulatory protein-1. J. Nutr. Biochem. 2007, 18, 449-456.
-
(2007)
J. Nutr. Biochem
, vol.18
, pp. 449-456
-
-
Huang, C.-S.1
Fan, Y.-E.2
Lin, C.-Y.3
Hu, M.-L.4
-
220
-
-
84867135314
-
Comparative antioxidant effects of lycopene, apo-10′-lycopenoic acid and apo-14′-lycopenoic acid in human macrophages exposed to H2O2 and cigarette smoke extract
-
Catalano, A.; Simone, R.E.; Cittadini, A.; Reynaud, E.; Caris-Veyrat, C.; Palozza, P. Comparative antioxidant effects of lycopene, apo-10′-lycopenoic acid and apo-14′-lycopenoic acid in human macrophages exposed to H2O2 and cigarette smoke extract. Food Chem. Toxicol. 2013, 51, 71-79.
-
(2013)
Food Chem. Toxicol
, vol.51
, pp. 71-79
-
-
Catalano, A.1
Simone, R.E.2
Cittadini, A.3
Reynaud, E.4
Caris-Veyrat, C.5
Palozza, P.6
-
221
-
-
0031889382
-
Lycopene: Chemistry, biology, and implications for human health and disease
-
Clinton, S.K. Lycopene: Chemistry, biology, and implications for human health and disease. Nutr. Rev. 1998, 56, 35-51.
-
(1998)
Nutr. Rev
, vol.56
, pp. 35-51
-
-
Clinton, S.K.1
-
222
-
-
49749133236
-
Enzymatic metabolites of lycopene induce Nrf2-mediated expression of phase II detoxifying/antioxidant enzymes in human bronchial epithelial cells
-
Lian, F.; Wang, X.D. Enzymatic metabolites of lycopene induce Nrf2-mediated expression of phase II detoxifying/antioxidant enzymes in human bronchial epithelial cells. Int. J. Cancer 2008, 123, 1262-1268.
-
(2008)
Int. J. Cancer
, vol.123
, pp. 1262-1268
-
-
Lian, F.1
Wang, X.D.2
-
223
-
-
0038407714
-
Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets
-
Liu, C.; Lian, F.; Smith, D.E.; Russell, R.M.; Wang, X.-D. Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets. Cancer Res. 2003, 63, 3138-3144.
-
(2003)
Cancer Res
, vol.63
, pp. 3138-3144
-
-
Liu, C.1
Lian, F.2
Smith, D.E.3
Russell, R.M.4
Wang, X.-D.5
-
224
-
-
84890493012
-
Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice
-
Ip, B.C.; Hu, K.Q.; Liu, C.; Smith, D.E.; Obin, M.S.; Ausman, L.M.; Wang, X.D. Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice. Cancer Prev. Res. 2013, 6, 1304-1316.
-
(2013)
Cancer Prev. Res
, vol.6
, pp. 1304-1316
-
-
Ip, B.C.1
Hu, K.Q.2
Liu, C.3
Smith, D.E.4
Obin, M.S.5
Ausman, L.M.6
Wang, X.D.7
-
225
-
-
0034686994
-
Tomato lycopene and its role in human health and chronic diseases
-
Agarwal, S.; Rao, A.V. Tomato lycopene and its role in human health and chronic diseases. Can. Med. Assoc. J. 2000, 163, 739-744.
-
(2000)
Can. Med. Assoc. J
, vol.163
, pp. 739-744
-
-
Agarwal, S.1
Rao, A.V.2
-
226
-
-
0031796505
-
Tomato lycopene and low density lipoprotein oxidation: A human dietary intervention study
-
Agarwal, S.; Rao, A.V. Tomato lycopene and low density lipoprotein oxidation: A human dietary intervention study. Lipids 1998, 33, 981-984.
-
(1998)
Lipids
, vol.33
, pp. 981-984
-
-
Agarwal, S.1
Rao, A.V.2
-
227
-
-
0028864835
-
Vitamins E and C, β-carotene, and other carotenoids as antioxidants
-
Sies, H.; Stahl, W. Vitamins E and C, β-carotene, and other carotenoids as antioxidants. Am. J. Clin. Nutr. 1995, 62, 1315S-1321S.
-
(1995)
Am. J. Clin. Nutr
, vol.62
-
-
Sies, H.1
Stahl, W.2
-
228
-
-
77955614681
-
Tomato lycopene and inflammatory cascade: Basic interactions and clinical implications
-
Palozza, P.; Parrone, N.; Catalano, A.; Simone, R. Tomato lycopene and inflammatory cascade: Basic interactions and clinical implications. Curr. Med. Chem. 2010, 17, 2547-2563.
-
(2010)
Curr. Med. Chem
, vol.17
, pp. 2547-2563
-
-
Palozza, P.1
Parrone, N.2
Catalano, A.3
Simone, R.4
-
229
-
-
60549109477
-
Biological activity of lycopene metabolites: Implications for cancer prevention
-
Mein, J.R.; Lian, F.; Wang, X.D. Biological activity of lycopene metabolites: Implications for cancer prevention. Nutr. Rev. 2008, 66, 667-683.
-
(2008)
Nutr. Rev
, vol.66
, pp. 667-683
-
-
Mein, J.R.1
Lian, F.2
Wang, X.D.3
-
230
-
-
84856905230
-
Apo-8′-lycopenal induces expression of HO-1 and NQO-1 via the ERK/p38-Nrf2-ARE pathway in human HepG2 cells
-
Yang, C.M.; Huang, S.M.; Liu, C.L.; Hu, M.L. Apo-8′-lycopenal induces expression of HO-1 and NQO-1 via the ERK/p38-Nrf2-ARE pathway in human HepG2 cells. J. Agric. Food Chem. 2012, 60, 1576-1585.
-
(2012)
J. Agric. Food Chem
, vol.60
, pp. 1576-1585
-
-
Yang, C.M.1
Huang, S.M.2
Liu, C.L.3
Hu, M.L.4
-
231
-
-
84939272373
-
-
Boston, MA, USA. Unpublished work
-
Ip, B.C.; Wang, X.D. Tufts University, Boston, MA, USA. Unpublished work, 2013.
-
(2013)
Tufts University
-
-
Ip, B.C.1
Wang, X.D.2
-
232
-
-
37549036871
-
Expression of retinoid X receptor α is decreased in 3′-methyl-4- dimethylaminoazobenzene-induced hepatocellular carcinoma in rats
-
Ando, N.; Shimizu, M.; Okuno, M.; Matsushima-Nishiwaki, R.; Tsurumi, H.; Tanaka, T.; Moriwaki, H. Expression of retinoid X receptor α is decreased in 3′-methyl-4- dimethylaminoazobenzene-induced hepatocellular carcinoma in rats. Oncol. Rep. 2007, 18, 879-884.
-
(2007)
Oncol. Rep
, vol.18
, pp. 879-884
-
-
Ando, N.1
Shimizu, M.2
Okuno, M.3
Matsushima-Nishiwaki, R.4
Tsurumi, H.5
Tanaka, T.6
Moriwaki, H.7
-
233
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan, D.; Weinberg, R.A. Hallmarks of cancer: The next generation. Cell 2011, 144, 646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
234
-
-
0034241817
-
Overexpression of MMP-9 correlates with growth of small hepatocellular carcinoma
-
Sakamoto, Y.; Mafune, K.; Mori, M.; Shiraishi, T.; Imamura, H.; Takayama, T.; Makuuchi, M. Overexpression of MMP-9 correlates with growth of small hepatocellular carcinoma. Int. J. Oncol. 2000, 17, 237-243.
-
(2000)
Int. J. Oncol
, vol.17
, pp. 237-243
-
-
Sakamoto, Y.1
Mafune, K.2
Mori, M.3
Shiraishi, T.4
Imamura, H.5
Takayama, T.6
Makuuchi, M.7
-
235
-
-
84891423452
-
-
Boston, MA, USA. Unpublished work
-
Miao, B.; Wang, X.D. Tufts University, Boston, MA, USA. Unpublished work, 2012.
-
(2012)
Tufts University
-
-
Miao, B.1
Wang, X.D.2
-
236
-
-
79959355078
-
Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity
-
Gao, Z.; Zhang, J.; Kheterpal, I.; Kennedy, N.; Davis, R.J.; Ye, J. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. J. Biol. Chem. 2011, 286, 22227-22234.
-
(2011)
J. Biol. Chem
, vol.286
, pp. 22227-22234
-
-
Gao, Z.1
Zhang, J.2
Kheterpal, I.3
Kennedy, N.4
Davis, R.J.5
Ye, J.6
-
237
-
-
53649100104
-
JNK2-dependent regulation of SIRT1 protein stability
-
Ford, J.; Ahmed, S.; Allison, S.; Jiang, M.; Milner, J. JNK2-dependent regulation of SIRT1 protein stability. Cell Cycle 2008, 7, 3091-3097.
-
(2008)
Cell Cycle
, vol.7
, pp. 3091-3097
-
-
Ford, J.1
Ahmed, S.2
Allison, S.3
Jiang, M.4
Milner, J.5
-
238
-
-
84883823953
-
SIRT1 regulates adaptive response of the growth hormone-Insulin-like growth factor-I axis under fasting conditions in liver
-
Yamamoto, M.; Iguchi, G.; Fukuoka, H.; Suda, K.; Bando, H.; Takahashi, M.; Nishizawa, H.; Seino, S.; Takahashi, Y. SIRT1 regulates adaptive response of the growth hormone-Insulin-like growth factor-I axis under fasting conditions in liver. Proc. Natl. Acad. Sci. USA 2013, 110, 14948-14953.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 14948-14953
-
-
Yamamoto, M.1
Iguchi, G.2
Fukuoka, H.3
Suda, K.4
Bando, H.5
Takahashi, M.6
Nishizawa, H.7
Seino, S.8
Takahashi, Y.9
-
239
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur, J.A.; Pearson, K.J.; Price, N.L.; Jamieson, H.A.; Lerin, C.; Kalra, A.; Prabhu, V.V.; Allard, J.S.; Lopez-Lluch, G.; Lewis, K. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444, 337-342.
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
Prabhu, V.V.7
Allard, J.S.8
Lopez-Lluch, G.9
Lewis, K.10
-
240
-
-
84861852370
-
Are sirtuins viable targets for improving healthspan and lifespan?
-
Baur, J.A.; Ungvari, Z.; Minor, R.K.; Le Couteur, D.G.; de Cabo, R. Are sirtuins viable targets for improving healthspan and lifespan? Nat. Rev. Drug Discov. 2012, 11, 443-461.
-
(2012)
Nat. Rev. Drug Discov
, vol.11
, pp. 443-461
-
-
Baur, J.A.1
Ungvari, Z.2
Minor, R.K.3
Le Couteur, D.G.4
de Cabo, R.5
-
241
-
-
3242719545
-
Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
-
Yeung, F.; Hoberg, J.E.; Ramsey, C.S.; Keller, M.D.; Jones, D.R.; Frye, R.A.; Mayo, M.W. Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 2004, 23, 2369-2380.
-
(2004)
EMBO J
, vol.23
, pp. 2369-2380
-
-
Yeung, F.1
Hoberg, J.E.2
Ramsey, C.S.3
Keller, M.D.4
Jones, D.R.5
Frye, R.A.6
Mayo, M.W.7
|