A role for PPARα in the control of SREBP activity and lipid synthesis in the liver

Biochemical Journal

Volumn 389, Issue 2, 2005, Pages 413-421

  Knight, Brian L ^a   Hebbach, Abdel ^b   Hauton, David ^b   Brown, Anna Marie ^b   Wiggins, David ^b   Patel, Dilip D ^a   Gibbons, Geoffrey F ^b  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cholesterol and fatty acid synthesis; Fibrate; Gene expression; Peroxisome proliferator activated receptor (PPAR ); PPARA null mice; Sterol regulatory element binding protein (SREBP)

Indexed keywords

BIOLOGICAL ORGANS; FATTY ACIDS; FLUXES; GENES; OXIDATION; RNA; SYNTHESIS (CHEMICAL);

CARBON FLUX; FATTY ACID OXIDATION; HEPATIC EXPRESSION; LIPOGENESIS;

LIPIDS;

ACYL COENZYME A DESATURASE; ETOMOXIR; FATTY ACID SYNTHASE; FIBRIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PIRINIXIC ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; CHOLESTEROL; EPOXIDE; FATTY ACID; ISOPROTEIN; LIPID; MESSENGER RNA; PEROXISOME PROLIFERATOR; PYRIMIDINE DERIVATIVE; SREBF1 PROTEIN, MOUSE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL INTAKE; CHOLESTEROL SYNTHESIS; CIRCADIAN RHYTHM; CONTROLLED STUDY; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; FOOD INTAKE; GENE EXPRESSION; GENOTYPE; IN VIVO STUDY; LIPID BLOOD LEVEL; LIPID LIVER LEVEL; LIPOGENESIS; LIVER; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; ANIMAL; BIOSYNTHESIS; BLOOD; DRUG EFFECT; DRUG POTENTIATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE MUTANT;

ANIMALS; CHOLESTEROL; CHOLESTEROL, DIETARY; CIRCADIAN RHYTHM; EPOXY COMPOUNDS; FATTY ACIDS; GENE EXPRESSION REGULATION; LIPIDS; LIVER; MALE; MICE; MICE, KNOCKOUT; PEROXISOME PROLIFERATORS; PPAR ALPHA; PROTEIN ISOFORMS; PYRIMIDINES; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 22544473888     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041896     Document Type: Article

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